HAVCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.15371018
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.15371018
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.15371018
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.15371018
5modulation by symbiont of host immune response (GO:0052553)7.15371018
6positive regulation by symbiont of host defense response (GO:0052509)7.15371018
7microglial cell activation (GO:0001774)7.04791276
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.78478296
9cytidine deamination (GO:0009972)6.38529010
10cytidine metabolic process (GO:0046087)6.38529010
11cytidine catabolic process (GO:0006216)6.38529010
12regulation of interferon-beta biosynthetic process (GO:0045357)6.22001854
13macrophage activation involved in immune response (GO:0002281)5.87220053
14pyrimidine ribonucleoside catabolic process (GO:0046133)5.70694406
15regulation of B cell receptor signaling pathway (GO:0050855)5.35307580
16eosinophil chemotaxis (GO:0048245)5.17976300
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.91915270
18DNA deamination (GO:0045006)4.80195638
19macrophage activation (GO:0042116)4.72562609
20eosinophil migration (GO:0072677)4.66551289
21regulation of lymphocyte chemotaxis (GO:1901623)4.57907862
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.57737620
23response to host immune response (GO:0052572)4.57737620
24positive regulation of interferon-alpha production (GO:0032727)4.47478053
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.47197938
26positive regulation of chemokine secretion (GO:0090197)4.31700719
27regulation of interferon-alpha production (GO:0032647)4.31071251
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.27657303
29response to host (GO:0075136)4.27657303
30response to host defenses (GO:0052200)4.27657303
31positive regulation of antigen processing and presentation (GO:0002579)4.21204296
32cellular extravasation (GO:0045123)4.19772621
33neutrophil activation involved in immune response (GO:0002283)3.99043214
34regulation of gamma-delta T cell activation (GO:0046643)3.97573289
35positive regulation of lymphocyte migration (GO:2000403)3.97318997
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97097197
37I-kappaB phosphorylation (GO:0007252)3.89523987
38lymphocyte chemotaxis (GO:0048247)3.81256350
39macrophage chemotaxis (GO:0048246)3.80665513
40myeloid cell activation involved in immune response (GO:0002275)3.75011790
41T cell migration (GO:0072678)3.73318950
42negative regulation of granulocyte differentiation (GO:0030853)3.70500959
43regulation of gamma-delta T cell differentiation (GO:0045586)3.70079931
44regulation of antigen processing and presentation (GO:0002577)3.65081829
45positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.58046550
46positive regulation of calcium-mediated signaling (GO:0050850)3.55951570
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54179690
48positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52852620
49cellular response to interleukin-15 (GO:0071350)3.51942797
50immunoglobulin mediated immune response (GO:0016064)3.51229524
51response to peptidoglycan (GO:0032494)3.48152881
52regulation of lymphocyte migration (GO:2000401)3.47213961
53pinocytosis (GO:0006907)3.46428029
54glycosphingolipid catabolic process (GO:0046479)3.43715865
55positive regulation of gamma-delta T cell activation (GO:0046645)3.42842231
56regulation of tolerance induction (GO:0002643)3.42382763
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42213709
58negative regulation of cell killing (GO:0031342)3.41754952
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41754952
60negative regulation of interleukin-12 production (GO:0032695)3.37317901
61regulation of chemokine secretion (GO:0090196)3.33299797
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.32424433
63respiratory burst (GO:0045730)3.31930055
64regulation of regulatory T cell differentiation (GO:0045589)3.30675752
65phagocytosis, engulfment (GO:0006911)3.25106058
66G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.24973085
67regulation of mast cell degranulation (GO:0043304)3.22259375
68response to interleukin-15 (GO:0070672)3.21407333
69purinergic nucleotide receptor signaling pathway (GO:0035590)3.20318865
70Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19774193
71tolerance induction (GO:0002507)3.19715830
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.19092478
73myeloid leukocyte activation (GO:0002274)3.17827298
74B cell mediated immunity (GO:0019724)3.16537435
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15649808
76regulation of natural killer cell mediated immunity (GO:0002715)3.15649808
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.14643208
78positive regulation of T cell chemotaxis (GO:0010820)3.13841240
79regulation of T cell chemotaxis (GO:0010819)3.13841240
80regulation of mononuclear cell migration (GO:0071675)3.12630533
81antigen processing and presentation of endogenous antigen (GO:0019883)3.12090629
82positive T cell selection (GO:0043368)3.11932882
83regulation of macrophage chemotaxis (GO:0010758)3.11692784
84negative regulation by host of viral transcription (GO:0043922)3.11318635
85positive regulation of tolerance induction (GO:0002645)3.10215433
86response to muramyl dipeptide (GO:0032495)3.09211195
87positive regulation of B cell differentiation (GO:0045579)3.08884361
88regulation of mast cell activation involved in immune response (GO:0033006)3.08454396
89positive regulation of interleukin-8 secretion (GO:2000484)3.07322237
90regulation of activation of Janus kinase activity (GO:0010533)3.06889057
91hyaluronan catabolic process (GO:0030214)3.05499593
92neutrophil activation (GO:0042119)3.04926688
93positive regulation of defense response to virus by host (GO:0002230)3.04799745
94positive regulation of T cell migration (GO:2000406)3.04538812
95glycolipid catabolic process (GO:0019377)3.03866102
96germ cell migration (GO:0008354)3.03201881
97T cell costimulation (GO:0031295)3.03078470
98pyrimidine nucleoside catabolic process (GO:0046135)3.02666327
99amino sugar catabolic process (GO:0046348)3.02501482
100positive regulation of interferon-beta production (GO:0032728)3.02009690
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01901566
102positive regulation of cellular amide metabolic process (GO:0034250)3.01802988
103positive regulation of chemokine production (GO:0032722)3.01620142
104interferon-gamma-mediated signaling pathway (GO:0060333)3.00611034
105positive regulation of macrophage differentiation (GO:0045651)2.99242284
106lymphocyte costimulation (GO:0031294)2.99150721
107granulocyte activation (GO:0036230)2.98497632
108interferon-gamma production (GO:0032609)2.96809121
109positive regulation of mast cell activation (GO:0033005)2.96290231
110regulation of mast cell activation (GO:0033003)2.96241613
111dendritic cell chemotaxis (GO:0002407)2.95431689
112germinal center formation (GO:0002467)2.93825488
113negative regulation of B cell proliferation (GO:0030889)2.92376937
114regulation of T cell tolerance induction (GO:0002664)2.91932299
115negative regulation of viral genome replication (GO:0045071)2.90664199
116B cell receptor signaling pathway (GO:0050853)2.88849102
117B cell homeostasis (GO:0001782)2.88819227
118oligosaccharide catabolic process (GO:0009313)2.88724399
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88340246
120ceramide catabolic process (GO:0046514)2.87902316
121monocyte chemotaxis (GO:0002548)2.87078886
122positive regulation of interleukin-1 beta secretion (GO:0050718)2.86593570
123positive regulation of natural killer cell mediated immunity (GO:0002717)2.85630976
124regulation of T cell migration (GO:2000404)2.84533100
125detection of molecule of bacterial origin (GO:0032490)2.83256008
126regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83008971
127positive regulation of mast cell activation involved in immune response (GO:0033008)2.82538313
128positive regulation of mast cell degranulation (GO:0043306)2.82538313
129regulation of chemokine-mediated signaling pathway (GO:0070099)2.82451987
130regulation of calcium-mediated signaling (GO:0050848)2.82277985
131positive regulation of neutrophil chemotaxis (GO:0090023)2.82044825
132positive regulation of neutrophil migration (GO:1902624)2.82044825
133regulation of chronic inflammatory response (GO:0002676)2.81425710
134lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80591254
135actin nucleation (GO:0045010)2.80458937
136positive thymic T cell selection (GO:0045059)2.78475352
137mature B cell differentiation (GO:0002335)2.78446398
138chemokine-mediated signaling pathway (GO:0070098)2.78433535
139regulation of interferon-gamma biosynthetic process (GO:0045072)2.78423298
140positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.77094549
141myeloid dendritic cell activation (GO:0001773)2.75509985
142production of molecular mediator involved in inflammatory response (GO:0002532)2.75432918
143negative T cell selection (GO:0043383)2.75268625
144myeloid dendritic cell differentiation (GO:0043011)2.71878926
145purinergic receptor signaling pathway (GO:0035587)2.71587121
146negative regulation of interleukin-17 production (GO:0032700)2.71457108
147regulation of leukocyte degranulation (GO:0043300)2.70183407
148positive regulation of chemokine biosynthetic process (GO:0045080)2.69679211
149leukocyte aggregation (GO:0070486)2.69066844
150response to cholesterol (GO:0070723)2.67392604
151cellular defense response (GO:0006968)2.67162645
152regulation of monocyte chemotaxis (GO:0090025)2.66423840
153positive regulation of monocyte chemotaxis (GO:0090026)2.65816664
154regulation of B cell differentiation (GO:0045577)2.65632506
155regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65052336
156positive regulation of interleukin-1 secretion (GO:0050716)2.63415988
157negative regulation of mast cell activation (GO:0033004)2.62032593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.06816979
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.79461244
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.95352508
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.79968343
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.70011756
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.35132131
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88308977
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.68393291
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62005363
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37244915
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.33411510
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.24682093
13SCL_19346495_ChIP-Seq_HPC-7_Human2.98056260
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90242382
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87616588
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66371651
17RUNX_20019798_ChIP-Seq_JUKART_Human2.62929666
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62897345
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31416386
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30719525
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30648790
22SPI1_23127762_ChIP-Seq_K562_Human2.17511469
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16491060
24* SPI1_23547873_ChIP-Seq_NB4_Human2.04213876
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03499584
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02313692
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00276193
28MYB_26560356_Chip-Seq_TH2_Human1.98345635
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.96022381
30* PU_27001747_Chip-Seq_BMDM_Mouse1.88427072
31VDR_24787735_ChIP-Seq_THP-1_Human1.86266479
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82994242
33VDR_24763502_ChIP-Seq_THP-1_Human1.80685163
34MAF_26560356_Chip-Seq_TH1_Human1.74188866
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72001994
36* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69464935
37VDR_21846776_ChIP-Seq_THP-1_Human1.68946863
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.65362712
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63400694
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61619496
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.56455196
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56023276
43MYB_26560356_Chip-Seq_TH1_Human1.54357968
44TCF7_22412390_ChIP-Seq_EML_Mouse1.50065684
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47985918
46GATA1_22025678_ChIP-Seq_K562_Human1.45092437
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41104304
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40932753
49* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40128258
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.38652054
51UTX_26944678_Chip-Seq_JUKART_Human1.34853601
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34373608
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.33599812
54* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32597118
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29720823
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27261032
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22747290
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17695723
59GATA3_26560356_Chip-Seq_TH2_Human1.15209627
60MYC_22102868_ChIP-Seq_BL_Human1.14886626
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13778054
62* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12055834
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08848363
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08194447
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07915959
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06352984
67* GATA1_19941827_ChIP-Seq_MEL_Mouse1.06192133
68* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04720420
69* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04098538
70GATA2_19941826_ChIP-Seq_K562_Human1.03117635
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00981379
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99536580
73GATA1_19941826_ChIP-Seq_K562_Human0.98850119
74STAT1_20625510_ChIP-Seq_HELA_Human0.98348351
75KDM2B_26808549_Chip-Seq_DND41_Human0.97894202
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96848116
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95770857
78ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95725622
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94842788
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94391072
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93999981
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93560253
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93197878
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.90405565
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90402185
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90176866
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89702236
88* BCL6_27268052_Chip-Seq_Bcells_Human0.89137703
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87461663
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86863918
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86419722
92CJUN_26792858_Chip-Seq_BT549_Human0.85472341
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84323300
94MAF_26560356_Chip-Seq_TH2_Human0.84185109
95EGR1_19032775_ChIP-ChIP_M12_Human0.83783682
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.83264230
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.82968965
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82605164
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81784709
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80529438
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79313272
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76739304
103FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76499669
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.74669824
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74179603
106GATA3_26560356_Chip-Seq_TH1_Human0.73925415
107* SMRT_27268052_Chip-Seq_Bcells_Human0.73619735
108HTT_18923047_ChIP-ChIP_STHdh_Human0.72517967
109TFEB_21752829_ChIP-Seq_HELA_Human0.72356048
110BCOR_27268052_Chip-Seq_Bcells_Human0.71435773
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70687717
112TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70505706
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70148747
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.69908390
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68150140
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68061252
117SPI1_20517297_ChIP-Seq_HL60_Human0.66901902
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65163126
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65139732
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.64799644
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.64083918
122RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63979998
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.63606579
124SOX2_20726797_ChIP-Seq_SW620_Human0.63273395
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.63111103
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62916502
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62590004
128* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.62526376
129* TAF2_19829295_ChIP-Seq_ESCs_Human0.62390819
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.61893118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.55244162
2MP0006082_CNS_inflammation4.19132393
3MP0005058_abnormal_lysosome_morphology3.63135631
4MP0005671_abnormal_response_to3.58895007
5MP0003303_peritoneal_inflammation3.35982354
6MP0003436_decreased_susceptibility_to3.28215404
7MP0003191_abnormal_cellular_cholesterol3.25122093
8MP0003172_abnormal_lysosome_physiology3.11409857
9MP0002419_abnormal_innate_immunity3.06306777
10MP0002148_abnormal_hypersensitivity_rea2.85338897
11MP0005000_abnormal_immune_tolerance2.78650508
12MP0005464_abnormal_platelet_physiology2.77354805
13MP0002452_abnormal_antigen_presenting2.67934306
14MP0004510_myositis2.55461820
15MP0001800_abnormal_humoral_immune2.52382191
16MP0002723_abnormal_immune_serum2.41113081
17MP0001790_abnormal_immune_system2.37322707
18MP0005387_immune_system_phenotype2.37322707
19MP0005025_abnormal_response_to2.29476364
20MP0003300_gastrointestinal_ulcer2.28370017
21MP0001819_abnormal_immune_cell2.26698759
22MP0002420_abnormal_adaptive_immunity2.22521395
23MP0001533_abnormal_skeleton_physiology2.14136898
24MP0009785_altered_susceptibility_to2.04814304
25MP0001853_heart_inflammation2.01747502
26MP0000685_abnormal_immune_system1.93944613
27MP0003724_increased_susceptibility_to1.90455922
28MP0002405_respiratory_system_inflammati1.82467080
29MP0000569_abnormal_digit_pigmentation1.79231596
30MP0000343_altered_response_to1.74555069
31MP0005310_abnormal_salivary_gland1.72926494
32MP0002396_abnormal_hematopoietic_system1.72335918
33MP0001845_abnormal_inflammatory_respons1.70863465
34MP0000716_abnormal_immune_system1.68088186
35MP0001851_eye_inflammation1.67173940
36MP0002398_abnormal_bone_marrow1.60360620
37MP0002998_abnormal_bone_remodeling1.57770550
38MP0003690_abnormal_glial_cell1.57058849
39MP0009333_abnormal_splenocyte_physiolog1.56526815
40MP0003828_pulmonary_edema1.56208941
41MP0000465_gastrointestinal_hemorrhage1.55158490
42MP0003075_altered_response_to1.54402199
43MP0004947_skin_inflammation1.53912102
44MP0003183_abnormal_peptide_metabolism1.52975583
45MP0003448_altered_tumor_morphology1.49676074
46MP0000689_abnormal_spleen_morphology1.48051127
47MP0002277_abnormal_respiratory_mucosa1.46702865
48MP0008469_abnormal_protein_level1.44951217
49MP0009840_abnormal_foam_cell1.40514195
50MP0003195_calcinosis1.40195375
51MP0002722_abnormal_immune_system1.37297024
52MP0002429_abnormal_blood_cell1.34774621
53MP0008004_abnormal_stomach_pH1.34439212
54MP0005257_abnormal_intraocular_pressure1.33374521
55MP0002166_altered_tumor_susceptibility1.31807749
56MP0010155_abnormal_intestine_physiology1.31563893
57MP0003566_abnormal_cell_adhesion1.31451371
58MP0005166_decreased_susceptibility_to1.30899330
59MP0002933_joint_inflammation1.29287966
60MP0002139_abnormal_hepatobiliary_system1.25202959
61MP0001873_stomach_inflammation1.22120170
62MP0003045_fibrosis1.20395669
63MP0009278_abnormal_bone_marrow1.18281608
64MP0003329_amyloid_beta_deposits1.14330754
65MP0000858_altered_metastatic_potential1.12036270
66MP0005390_skeleton_phenotype1.08212043
67MP0010307_abnormal_tumor_latency1.07059299
68MP0002006_tumorigenesis1.06858104
69MP0002090_abnormal_vision1.06217503
70MP0003806_abnormal_nucleotide_metabolis1.04475161
71MP0001545_abnormal_hematopoietic_system1.04061329
72MP0005397_hematopoietic_system_phenotyp1.04061329
73MP0009764_decreased_sensitivity_to1.03123251
74MP0000767_abnormal_smooth_muscle1.01654677
75MP0002254_reproductive_system_inflammat1.00434404
76MP0000604_amyloidosis0.99017153
77MP0000249_abnormal_blood_vessel0.97996388
78MP0008438_abnormal_cutaneous_collagen0.94886011
79MP0002928_abnormal_bile_duct0.94260949
80MP0000703_abnormal_thymus_morphology0.92956359
81MP0004808_abnormal_hematopoietic_stem0.91685759
82MP0003763_abnormal_thymus_physiology0.88164929
83MP0005023_abnormal_wound_healing0.85243583
84MP0004883_abnormal_blood_vessel0.85220196
85MP0001915_intracranial_hemorrhage0.84234636
86MP0000371_diluted_coat_color0.83918428
87MP0009765_abnormal_xenobiotic_induced0.82812595
88MP0005076_abnormal_cell_differentiation0.81970770
89MP0005174_abnormal_tail_pigmentation0.81912914
90MP0003795_abnormal_bone_structure0.79731071
91MP0005165_increased_susceptibility_to0.78599243
92MP0000920_abnormal_myelination0.77689943
93MP0000490_abnormal_crypts_of0.77189204
94MP0002877_abnormal_melanocyte_morpholog0.75592800
95MP0005164_abnormal_response_to0.74056727
96MP0000015_abnormal_ear_pigmentation0.73410077
97MP0002138_abnormal_hepatobiliary_system0.72354327
98MP0002693_abnormal_pancreas_physiology0.70555741
99MP0009763_increased_sensitivity_to0.69858251
100MP0003091_abnormal_cell_migration0.69850757
101MP0005365_abnormal_bile_salt0.68544117
102MP0005167_abnormal_blood-brain_barrier0.68303166
103MP0003252_abnormal_bile_duct0.66571350
104MP0005584_abnormal_enzyme/coenzyme_acti0.66417684
105MP0003453_abnormal_keratinocyte_physiol0.66003562
106MP0003279_aneurysm0.65436884
107MP0008873_increased_physiological_sensi0.65200004
108MP0005197_abnormal_uvea_morphology0.64654281
109MP0003656_abnormal_erythrocyte_physiolo0.63123953
110MP0003866_abnormal_defecation0.61343576
111MP0005075_abnormal_melanosome_morpholog0.60771330
112MP0001542_abnormal_bone_strength0.58904012
113MP0004185_abnormal_adipocyte_glucose0.58639963
114MP0002136_abnormal_kidney_physiology0.58410322
115MP0002837_dystrophic_cardiac_calcinosis0.58304956
116MP0005319_abnormal_enzyme/_coenzyme0.55068746
117MP0001986_abnormal_taste_sensitivity0.53349921
118MP0005451_abnormal_body_composition0.52384901
119MP0001663_abnormal_digestive_system0.52220879
120MP0004742_abnormal_vestibular_system0.51328455

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.39635898
2Increased cerebral lipofuscin (HP:0011813)6.06705735
3Increased neuronal autofluorescent lipopigment (HP:0002074)5.88166825
4Recurrent abscess formation (HP:0002722)5.69638599
5Abnormality of liposaccharide metabolism (HP:0010968)5.51946114
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.51946114
7Abnormality of glycolipid metabolism (HP:0010969)5.51946114
8T lymphocytopenia (HP:0005403)5.34040529
9Recurrent bacterial skin infections (HP:0005406)5.10076664
10Abnormality of T cell number (HP:0011839)5.01261569
11Eczematoid dermatitis (HP:0000976)4.69272412
12Glomerulonephritis (HP:0000099)4.67545006
13Dysostosis multiplex (HP:0000943)4.30093042
14Arterial tortuosity (HP:0005116)4.28578536
15Cerebral aneurysm (HP:0004944)4.19182642
16Vacuolated lymphocytes (HP:0001922)3.90149377
17Vascular tortuosity (HP:0004948)3.77155805
18Recurrent gram-negative bacterial infections (HP:0005420)3.69456011
19Abnormality of macrophages (HP:0004311)3.57009625
20Recurrent skin infections (HP:0001581)3.40160247
21Disinhibition (HP:0000734)3.39863114
22Mucopolysacchariduria (HP:0008155)3.36332388
23Urinary glycosaminoglycan excretion (HP:0003541)3.36332388
24Axonal loss (HP:0003447)3.36208225
25Myositis (HP:0100614)3.33009471
26Abnormality of T cells (HP:0002843)3.32848035
27Abnormality of polysaccharide metabolism (HP:0011012)3.30037111
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30037111
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30037111
30Complement deficiency (HP:0004431)3.23854823
31Aortic aneurysm (HP:0004942)3.18589503
32Hematochezia (HP:0002573)3.16976360
33Retinal atrophy (HP:0001105)3.11244166
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.08746401
35Abnormality of the prostate (HP:0008775)3.06918727
36Recurrent fungal infections (HP:0002841)3.06651917
37Chronic obstructive pulmonary disease (HP:0006510)3.06264784
38Obstructive lung disease (HP:0006536)3.06264784
39Abnormality of complement system (HP:0005339)2.96317745
40Agnosia (HP:0010524)2.91994960
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91730736
42Chronic diarrhea (HP:0002028)2.87357771
43Pathologic fracture (HP:0002756)2.81276131
44Encephalitis (HP:0002383)2.80651939
45Orchitis (HP:0100796)2.78672481
46Aortic dissection (HP:0002647)2.72599027
47Recurrent cutaneous fungal infections (HP:0011370)2.71572908
48Chronic mucocutaneous candidiasis (HP:0002728)2.71572908
49Retrobulbar optic neuritis (HP:0100654)2.70857558
50Optic neuritis (HP:0100653)2.70857558
51Nephritis (HP:0000123)2.69646893
52Elevated erythrocyte sedimentation rate (HP:0003565)2.68976075
53Gingivitis (HP:0000230)2.68177541
54Autoimmune hemolytic anemia (HP:0001890)2.68136486
55Loss of speech (HP:0002371)2.66528260
56Mediastinal lymphadenopathy (HP:0100721)2.64893325
57Hemiplegia (HP:0002301)2.58966290
58Myocardial infarction (HP:0001658)2.56324541
59Tetraparesis (HP:0002273)2.56030010
60Increased serum ferritin (HP:0003281)2.55459988
61Disproportionate tall stature (HP:0001519)2.53002483
62Mutism (HP:0002300)2.52978450
63Progressive visual loss (HP:0000529)2.49656709
64Thick nail (HP:0001805)2.49246053
65Colitis (HP:0002583)2.47468000
66Increased IgM level (HP:0003496)2.46293266
67Polyneuropathy (HP:0001271)2.45691303
68Combined immunodeficiency (HP:0005387)2.43618159
69IgG deficiency (HP:0004315)2.42728589
70Gangrene (HP:0100758)2.42002078
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.41871448
72Osteolytic defects of the hand bones (HP:0009699)2.41871448
73Abnormality of eosinophils (HP:0001879)2.41366790
74Chest pain (HP:0100749)2.41148786
75Recurrent viral infections (HP:0004429)2.40051599
76Prostate neoplasm (HP:0100787)2.39698874
77Pustule (HP:0200039)2.39379358
78Hypoproteinemia (HP:0003075)2.39156770
79Striae distensae (HP:0001065)2.36577708
80Increased CSF protein (HP:0002922)2.34598684
81Spontaneous hematomas (HP:0007420)2.33714867
82Stomatitis (HP:0010280)2.33316784
83Arterial thrombosis (HP:0004420)2.30989968
84Inflammation of the large intestine (HP:0002037)2.29908976
85Periodontitis (HP:0000704)2.27135384
86Spondylolisthesis (HP:0003302)2.27062289
87Pulmonary embolism (HP:0002204)2.25342484
88Joint swelling (HP:0001386)2.24476925
89Eosinophilia (HP:0001880)2.22880280
90Gastrointestinal infarctions (HP:0005244)2.22678177
91Vasculitis (HP:0002633)2.21406326
92Vertebral compression fractures (HP:0002953)2.20813261
93Abnormality of iron homeostasis (HP:0011031)2.19447011
94Abnormality of the pleura (HP:0002103)2.19042022
95Keratoconjunctivitis sicca (HP:0001097)2.18684992
96Urethral obstruction (HP:0000796)2.17629326
97Bone pain (HP:0002653)2.16207773
98Pulmonary fibrosis (HP:0002206)2.15614797
99Cellulitis (HP:0100658)2.15579738
100Recurrent pneumonia (HP:0006532)2.15486921
101Upper motor neuron abnormality (HP:0002127)2.15163657
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14838098
103Meningitis (HP:0001287)2.14436577
104Hepatosplenomegaly (HP:0001433)2.13914542
105Autoimmune thrombocytopenia (HP:0001973)2.11345697
106Abnormal platelet function (HP:0011869)2.10713708
107Impaired platelet aggregation (HP:0003540)2.10713708
108Keratoconjunctivitis (HP:0001096)2.09719413
109Neurofibrillary tangles (HP:0002185)2.09585299
110Chronic otitis media (HP:0000389)2.08631784
111Osteomyelitis (HP:0002754)2.08217393
112Basal ganglia calcification (HP:0002135)2.07571535
113Leukocytosis (HP:0001974)2.07411641
114Gingival bleeding (HP:0000225)2.06797841
115Cheilitis (HP:0100825)2.06343638
116Gastrointestinal inflammation (HP:0004386)2.06319482
117Prolonged bleeding time (HP:0003010)2.05829101
118Petechiae (HP:0000967)2.05518672
119Interstitial pulmonary disease (HP:0006530)2.04923120
120Severe combined immunodeficiency (HP:0004430)2.04731047
121Progressive neurologic deterioration (HP:0002344)2.02988477
122Granulocytopenia (HP:0001913)2.02857092
123Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02823938
124Thoracic kyphosis (HP:0002942)2.02783669
125Pulmonary infiltrates (HP:0002113)2.02752580
126J-shaped sella turcica (HP:0002680)2.01406021
127Urticaria (HP:0001025)2.01323299
128Neuronal loss in central nervous system (HP:0002529)2.00611024
129Hemoptysis (HP:0002105)1.98650135
130Abnormality of transition element cation homeostasis (HP:0011030)1.98228416
131Amaurosis fugax (HP:0100576)1.98087409
132Aplastic anemia (HP:0001915)1.97984036
133Purpura (HP:0000979)1.97791030
134Recurrent bronchitis (HP:0002837)1.97474919
135Premature loss of primary teeth (HP:0006323)1.94947955
136Mitral valve prolapse (HP:0001634)1.92782239
137IgM deficiency (HP:0002850)1.91609244
138Agammaglobulinemia (HP:0004432)1.91003051
139Inappropriate behavior (HP:0000719)1.90796959
140Albinism (HP:0001022)1.89924311
141Thyroiditis (HP:0100646)1.89503780
142Abnormality of T cell physiology (HP:0011840)1.88684443
143Global brain atrophy (HP:0002283)1.87867282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR27.03816633
2GRK73.31369997
3MAP4K12.86694773
4TYK22.84434522
5CSF1R2.73754417
6MAPK152.60460316
7MAP3K142.60053557
8IRAK42.55966793
9KIT2.51269275
10TBK12.49533572
11TXK2.47671859
12BCKDK2.37969386
13KDR2.37888043
14RIPK42.14934507
15ACVR1B2.01110505
16STK101.87803791
17BLK1.87398300
18JAK11.80919691
19IRAK31.76519126
20CAMK1D1.73887611
21ZAP701.73363189
22IKBKB1.61862927
23HCK1.61642869
24CSK1.61485747
25MAP3K131.48356498
26NEK91.44279887
27LYN1.43525162
28SYK1.39881285
29IKBKE1.34882265
30TEC1.32570646
31TESK21.32293870
32MATK1.30031784
33RPS6KA41.26351611
34BMPR21.26307156
35MAP2K31.23347676
36CAMK1G1.21659754
37PAK41.21378201
38JAK31.20657818
39ADRBK21.20086020
40LCK1.19714159
41BTK1.17696930
42TAOK31.17553363
43FES1.17345840
44SIK31.16607988
45MAP3K111.16539813
46SIK21.13485363
47DAPK21.13264627
48TNK21.12221980
49* ITK1.12209738
50PDK21.02845734
51MARK31.00953646
52MOS1.00869618
53FGR0.97701368
54JAK20.94902777
55MAP2K60.94840736
56EPHB10.94525574
57CHUK0.93916022
58CLK10.92481565
59MAP3K30.91923360
60MAPKAPK20.85596461
61ERN10.85180308
62CDK120.82117197
63IRAK10.80341921
64PIK3CA0.78969793
65MAPK120.78369459
66CDK30.75096362
67FRK0.73822802
68CAMKK20.73556426
69MAPK70.73370078
70CDK60.73278608
71TYRO30.71952733
72TSSK60.70419328
73TRPM70.70172677
74FGFR30.67859860
75PIK3CG0.67325660
76STK240.67064558
77EEF2K0.66382563
78ABL20.64699969
79PIM10.61816457
80MAPKAPK30.60107281
81IGF1R0.58144645
82EGFR0.57207965
83DDR20.56652043
84MAP3K10.54747280
85CAMKK10.54095605
86PRKCQ0.52257823
87TLK10.51148396
88VRK10.50636614
89DMPK0.50147104
90PDK10.49686554
91SCYL20.49554325
92EIF2AK20.49486842
93PAK20.47638606
94FGFR40.47151022
95CAMK40.46810370
96CDC42BPA0.46717210
97MELK0.45247708
98EPHA30.44686300
99BMPR1B0.43409378
100TTN0.43007870
101MAPK40.42384256
102PRKCD0.42361666
103TAOK20.42214761
104MST40.41673784
105STK40.41274808
106PRKAA20.39474262
107TAOK10.37895154
108GSK3A0.37709209
109GRK60.35498695
110NUAK10.35196899
111INSR0.34838444
112TGFBR10.34082607
113ABL10.33995356
114PTK60.33900092
115GRK10.32747629
116STK30.32669556
117PKN20.32491364
118PDPK10.30964865
119FYN0.30819711
120SGK30.30138347
121PDGFRB0.28142487
122PIM20.27645279
123MAPKAPK50.27595173
124RPS6KA60.25936243
125MAP4K20.25679644
126PKN10.25485445
127EIF2AK30.25181039
128PRKCA0.24011482
129LIMK10.23251428
130MAP2K70.23029140
131MAP3K80.22774280
132SRC0.22409436
133PRKD10.22232282
134PINK10.20715130
135MAP3K50.20116909
136PRKACG0.19466275
137NME20.18529320
138INSRR0.17000458

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.60750441
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.25486541
3Osteoclast differentiation_Homo sapiens_hsa043802.89630315
4Lysosome_Homo sapiens_hsa041422.83287284
5Leishmaniasis_Homo sapiens_hsa051402.78826839
6Other glycan degradation_Homo sapiens_hsa005112.67720676
7Antigen processing and presentation_Homo sapiens_hsa046122.37575984
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32502139
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20764631
10Graft-versus-host disease_Homo sapiens_hsa053322.19977137
11B cell receptor signaling pathway_Homo sapiens_hsa046622.18912849
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02127510
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98159889
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.94683849
15Pertussis_Homo sapiens_hsa051331.94496788
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.92704653
17Tuberculosis_Homo sapiens_hsa051521.90206085
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77400078
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72961696
20Measles_Homo sapiens_hsa051621.67568212
21Hematopoietic cell lineage_Homo sapiens_hsa046401.60298985
22Malaria_Homo sapiens_hsa051441.59429292
23Rheumatoid arthritis_Homo sapiens_hsa053231.56563197
24Legionellosis_Homo sapiens_hsa051341.55059845
25Toxoplasmosis_Homo sapiens_hsa051451.54319482
26Phagosome_Homo sapiens_hsa041451.46508568
27Allograft rejection_Homo sapiens_hsa053301.46397886
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.40163133
29Collecting duct acid secretion_Homo sapiens_hsa049661.37075637
30Salmonella infection_Homo sapiens_hsa051321.37069484
31Influenza A_Homo sapiens_hsa051641.33443459
32T cell receptor signaling pathway_Homo sapiens_hsa046601.33278079
33Chemokine signaling pathway_Homo sapiens_hsa040621.33268500
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32070928
35Apoptosis_Homo sapiens_hsa042101.29671308
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27156126
37Pancreatic cancer_Homo sapiens_hsa052121.21436688
38Shigellosis_Homo sapiens_hsa051311.20468717
39Chronic myeloid leukemia_Homo sapiens_hsa052201.18662875
40TNF signaling pathway_Homo sapiens_hsa046681.15810963
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.15072479
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13814387
43Hepatitis B_Homo sapiens_hsa051611.12641031
44Primary immunodeficiency_Homo sapiens_hsa053401.11193330
45Complement and coagulation cascades_Homo sapiens_hsa046101.08775419
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.03626603
47Platelet activation_Homo sapiens_hsa046111.01472424
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98364416
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96901945
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96553031
51Herpes simplex infection_Homo sapiens_hsa051680.95490279
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95191488
53Viral myocarditis_Homo sapiens_hsa054160.91827467
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89472389
55Prion diseases_Homo sapiens_hsa050200.87387203
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84316703
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83480164
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77638030
59Endocytosis_Homo sapiens_hsa041440.77064673
60African trypanosomiasis_Homo sapiens_hsa051430.75595820
61Asthma_Homo sapiens_hsa053100.73937394
62Acute myeloid leukemia_Homo sapiens_hsa052210.73228900
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.73131994
64Autoimmune thyroid disease_Homo sapiens_hsa053200.72979701
65Amoebiasis_Homo sapiens_hsa051460.71139669
66Colorectal cancer_Homo sapiens_hsa052100.69647286
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68894159
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68433876
69Renal cell carcinoma_Homo sapiens_hsa052110.65134311
70Sulfur metabolism_Homo sapiens_hsa009200.63422105
71Type I diabetes mellitus_Homo sapiens_hsa049400.60922738
72Proteasome_Homo sapiens_hsa030500.59720231
73Hepatitis C_Homo sapiens_hsa051600.59311379
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59051689
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58870854
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.57937823
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.57043478
78Notch signaling pathway_Homo sapiens_hsa043300.55204973
79Adherens junction_Homo sapiens_hsa045200.54763647
80Prolactin signaling pathway_Homo sapiens_hsa049170.54232042
81ABC transporters_Homo sapiens_hsa020100.53484361
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51194071
83HTLV-I infection_Homo sapiens_hsa051660.51014137
84Epstein-Barr virus infection_Homo sapiens_hsa051690.50434603
85Systemic lupus erythematosus_Homo sapiens_hsa053220.48350806
86Renin-angiotensin system_Homo sapiens_hsa046140.47724912
87Small cell lung cancer_Homo sapiens_hsa052220.46956281
88Viral carcinogenesis_Homo sapiens_hsa052030.45572362
89Ether lipid metabolism_Homo sapiens_hsa005650.44636750
90VEGF signaling pathway_Homo sapiens_hsa043700.44252803
91Rap1 signaling pathway_Homo sapiens_hsa040150.43557797
92MAPK signaling pathway_Homo sapiens_hsa040100.42407998
93FoxO signaling pathway_Homo sapiens_hsa040680.42357854
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41343893
95Proteoglycans in cancer_Homo sapiens_hsa052050.40698383
96Mineral absorption_Homo sapiens_hsa049780.39787971
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39177456
98Sphingolipid metabolism_Homo sapiens_hsa006000.38384456
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38223108
100Non-small cell lung cancer_Homo sapiens_hsa052230.37961397
101HIF-1 signaling pathway_Homo sapiens_hsa040660.37622889
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36329402
103Oxidative phosphorylation_Homo sapiens_hsa001900.35617806
104Vibrio cholerae infection_Homo sapiens_hsa051100.32874858
105Caffeine metabolism_Homo sapiens_hsa002320.32093950
106Focal adhesion_Homo sapiens_hsa045100.31808094
107MicroRNAs in cancer_Homo sapiens_hsa052060.29622126
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28784558
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27921146
110Nitrogen metabolism_Homo sapiens_hsa009100.27666556
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.27438557
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26678082
113Glioma_Homo sapiens_hsa052140.26606236
114Prostate cancer_Homo sapiens_hsa052150.25557961
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25095023
116PPAR signaling pathway_Homo sapiens_hsa033200.24750187
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22374792
118Linoleic acid metabolism_Homo sapiens_hsa005910.20904603
119Galactose metabolism_Homo sapiens_hsa000520.17632033
120Tryptophan metabolism_Homo sapiens_hsa003800.15278948
121Protein export_Homo sapiens_hsa030600.13555007
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.12142248
123Arachidonic acid metabolism_Homo sapiens_hsa005900.11519903
124Regulation of autophagy_Homo sapiens_hsa041400.10187967
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10130920
126Synaptic vesicle cycle_Homo sapiens_hsa047210.06677322
127Peroxisome_Homo sapiens_hsa041460.04638152
128Dorso-ventral axis formation_Homo sapiens_hsa043200.03999386
129Steroid biosynthesis_Homo sapiens_hsa001000.03793477

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