HAX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.66080091
2proteasome assembly (GO:0043248)4.56772890
3nucleobase biosynthetic process (GO:0046112)4.47391556
4formation of translation preinitiation complex (GO:0001731)4.38048097
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27207973
6ribosome assembly (GO:0042255)4.27188528
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21511160
8respiratory electron transport chain (GO:0022904)4.19290173
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.09559781
10electron transport chain (GO:0022900)4.09101144
11oxidative phosphorylation (GO:0006119)4.05214386
12anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.05172324
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.03571298
14mitotic metaphase plate congression (GO:0007080)3.93561409
15termination of RNA polymerase III transcription (GO:0006386)3.91357870
16transcription elongation from RNA polymerase III promoter (GO:0006385)3.91357870
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.87829751
18protein maturation by protein folding (GO:0022417)3.87200081
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.86494919
20negative regulation of ligase activity (GO:0051352)3.86494919
21maturation of SSU-rRNA (GO:0030490)3.86230425
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84230801
237-methylguanosine mRNA capping (GO:0006370)3.83985695
24ribosome biogenesis (GO:0042254)3.80441658
25cullin deneddylation (GO:0010388)3.78613515
26rRNA modification (GO:0000154)3.77319783
27protein deneddylation (GO:0000338)3.76010232
28RNA capping (GO:0036260)3.74585304
297-methylguanosine RNA capping (GO:0009452)3.74585304
30amino acid salvage (GO:0043102)3.72764227
31L-methionine salvage (GO:0071267)3.72764227
32L-methionine biosynthetic process (GO:0071265)3.72764227
33regulation of cellular amino acid metabolic process (GO:0006521)3.72215891
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.71582970
35folic acid metabolic process (GO:0046655)3.70053009
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.70034749
37tRNA aminoacylation for protein translation (GO:0006418)3.68272928
38ribosomal small subunit assembly (GO:0000028)3.65414272
39ribonucleoprotein complex biogenesis (GO:0022613)3.64749105
40folic acid-containing compound biosynthetic process (GO:0009396)3.64222998
41amino acid activation (GO:0043038)3.62312854
42tRNA aminoacylation (GO:0043039)3.62312854
43ribosomal large subunit biogenesis (GO:0042273)3.61909214
44DNA deamination (GO:0045006)3.58316922
45nucleobase-containing small molecule interconversion (GO:0015949)3.57691615
46positive regulation of ligase activity (GO:0051351)3.56028295
47protein complex biogenesis (GO:0070271)3.55487949
48respiratory chain complex IV assembly (GO:0008535)3.55047455
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54551227
50DNA replication checkpoint (GO:0000076)3.51018127
51ribosomal small subunit biogenesis (GO:0042274)3.48690638
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48108131
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48108131
54mitochondrial respiratory chain complex assembly (GO:0033108)3.47720579
55L-serine metabolic process (GO:0006563)3.46440541
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45484095
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45484095
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45484095
59protein localization to mitochondrion (GO:0070585)3.45473328
60DNA replication initiation (GO:0006270)3.42098904
61tricarboxylic acid cycle (GO:0006099)3.41896909
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.41348937
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41348937
64spliceosomal snRNP assembly (GO:0000387)3.40965164
65rRNA processing (GO:0006364)3.40912320
66DNA strand elongation involved in DNA replication (GO:0006271)3.40395689
67maturation of 5.8S rRNA (GO:0000460)3.38729501
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.35764809
69serine family amino acid biosynthetic process (GO:0009070)3.31103347
70regulation of ubiquitin-protein transferase activity (GO:0051438)3.30759067
71protein neddylation (GO:0045116)3.30711251
72NADH metabolic process (GO:0006734)3.29590294
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28977606
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28843833
75rRNA metabolic process (GO:0016072)3.27535634
76DNA strand elongation (GO:0022616)3.25039265
77cytochrome complex assembly (GO:0017004)3.20473548
78regulation of mitochondrial translation (GO:0070129)3.20282072
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19681774
80regulation of ligase activity (GO:0051340)3.19477923
81peptidyl-histidine modification (GO:0018202)3.18266044
82protein localization to endoplasmic reticulum (GO:0070972)3.17629286
83regulation of translational fidelity (GO:0006450)3.16894745
84establishment of viral latency (GO:0019043)3.16385466
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.15797056
86NADH dehydrogenase complex assembly (GO:0010257)3.15797056
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15797056
88cellular component biogenesis (GO:0044085)3.15775120
89translational initiation (GO:0006413)3.15678063
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.14341718
91rRNA methylation (GO:0031167)3.11374739
92transcription-coupled nucleotide-excision repair (GO:0006283)3.10875739
93metaphase plate congression (GO:0051310)3.10830277
94G1/S transition of mitotic cell cycle (GO:0000082)3.10637081
95cell cycle G1/S phase transition (GO:0044843)3.10637081
96aerobic respiration (GO:0009060)3.09869377
97translation (GO:0006412)3.09526830
98inner mitochondrial membrane organization (GO:0007007)3.08111093
99termination of RNA polymerase I transcription (GO:0006363)3.07703932
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07457078
101pteridine-containing compound biosynthetic process (GO:0042559)3.06611193
102transcription from RNA polymerase I promoter (GO:0006360)3.06591321
103glycine metabolic process (GO:0006544)3.04209099
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03938578
105CENP-A containing nucleosome assembly (GO:0034080)3.02451691
106mitochondrial transport (GO:0006839)3.02085807
107chaperone-mediated protein transport (GO:0072321)3.01407236
108methionine biosynthetic process (GO:0009086)3.00514555
109translational termination (GO:0006415)3.00477272
110transcription from mitochondrial promoter (GO:0006390)2.99908224
111Golgi transport vesicle coating (GO:0048200)2.99697729
112COPI coating of Golgi vesicle (GO:0048205)2.99697729
113establishment of integrated proviral latency (GO:0075713)2.99191988
114transcription elongation from RNA polymerase II promoter (GO:0006368)2.97408327
115viral transcription (GO:0019083)2.97227766
116telomere maintenance via semi-conservative replication (GO:0032201)2.96364566
117cotranslational protein targeting to membrane (GO:0006613)2.95774400
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95297828
119ATP synthesis coupled proton transport (GO:0015986)2.95169061
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95169061
121chromatin remodeling at centromere (GO:0031055)2.95062753
122regulation of cellular amine metabolic process (GO:0033238)2.94397418
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93607725
124establishment of protein localization to mitochondrion (GO:0072655)2.92921584
125tetrahydrofolate metabolic process (GO:0046653)2.92113763
126protein targeting to ER (GO:0045047)2.91235609
127guanosine-containing compound biosynthetic process (GO:1901070)2.89499389
128IMP biosynthetic process (GO:0006188)2.89154181
129folic acid-containing compound metabolic process (GO:0006760)2.87541597
130aspartate family amino acid biosynthetic process (GO:0009067)2.86953047
131DNA replication-dependent nucleosome assembly (GO:0006335)2.85848344
132DNA replication-dependent nucleosome organization (GO:0034723)2.85848344
133pseudouridine synthesis (GO:0001522)2.85004280
134protein targeting to mitochondrion (GO:0006626)2.84734822
135DNA-templated transcription, elongation (GO:0006354)2.84441186
136positive regulation of cell cycle arrest (GO:0071158)2.83702529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.86176855
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28155427
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19153145
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.94542286
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85723635
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73231948
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.58809515
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56753670
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50845537
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25529509
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00179404
12* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92146607
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87131757
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84173751
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81645561
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63509259
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63159831
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52127932
19XRN2_22483619_ChIP-Seq_HELA_Human2.44894403
20* VDR_23849224_ChIP-Seq_CD4+_Human2.43506687
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40092369
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38293556
23DCP1A_22483619_ChIP-Seq_HELA_Human2.37940682
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34370922
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32598905
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.23081230
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19124017
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17349173
29GABP_19822575_ChIP-Seq_HepG2_Human2.15022489
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06082089
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05034951
32FOXP3_21729870_ChIP-Seq_TREG_Human1.99986886
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99204873
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98213629
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.95894670
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93348681
37AR_21909140_ChIP-Seq_LNCAP_Human1.88737203
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.87883114
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86915705
40TTF2_22483619_ChIP-Seq_HELA_Human1.85381754
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84771840
42ELK1_19687146_ChIP-ChIP_HELA_Human1.80353264
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77386872
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71938190
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67881681
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67416727
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65907300
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65425522
49ZNF263_19887448_ChIP-Seq_K562_Human1.58168031
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54848799
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50115609
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49486483
53* KDM5A_27292631_Chip-Seq_BREAST_Human1.48513226
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43988320
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42877082
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40700424
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.35745961
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35536646
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34728792
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34206417
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34181905
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32171343
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31093003
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27895635
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25194590
66TFEB_21752829_ChIP-Seq_HELA_Human1.23921697
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23915356
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.19066726
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18518548
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17631268
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15583911
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15412585
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12583410
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10514610
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09856940
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08262581
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05800556
78MYC_18940864_ChIP-ChIP_HL60_Human1.04988720
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02706274
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02570580
81CIITA_25753668_ChIP-Seq_RAJI_Human1.01228692
82* SOX17_20123909_ChIP-Seq_XEN_Mouse1.01137995
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00750125
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00747106
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99714382
86SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99709472
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99280883
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98268428
89OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98000286
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96027914
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95584266
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95094110
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93960304
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93844365
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93598282
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93508959
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93324676
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92403255
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90604222
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89769622
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88041758
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85998224
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85607276
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85381796
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84055900
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83722563
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83206456
108* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83042248
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81570274
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.81405043
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80450138
112CHD1_26751641_Chip-Seq_LNCaP_Human0.80421945
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.80303228
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79053462
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78336906
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78336906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.64190969
2MP0003806_abnormal_nucleotide_metabolis4.94657603
3MP0004957_abnormal_blastocyst_morpholog4.47531677
4MP0003718_maternal_effect3.64772727
5MP0003111_abnormal_nucleus_morphology3.62524217
6MP0003077_abnormal_cell_cycle3.45853214
7MP0010094_abnormal_chromosome_stability3.33948312
8MP0008932_abnormal_embryonic_tissue3.10077676
9MP0008057_abnormal_DNA_replication2.93954010
10MP0003186_abnormal_redox_activity2.75830871
11MP0003123_paternal_imprinting2.75402448
12MP0002837_dystrophic_cardiac_calcinosis2.56596178
13MP0002139_abnormal_hepatobiliary_system2.39210664
14MP0008058_abnormal_DNA_repair2.37845791
15MP0008260_abnormal_autophagy2.36574469
16MP0001730_embryonic_growth_arrest2.35556427
17MP0009840_abnormal_foam_cell2.23945476
18MP0004233_abnormal_muscle_weight2.17862707
19MP0000372_irregular_coat_pigmentation2.14709351
20MP0001529_abnormal_vocalization2.10422341
21MP0010234_abnormal_vibrissa_follicle2.06001640
22MP0000749_muscle_degeneration1.91005144
23MP0005451_abnormal_body_composition1.88683271
24MP0003786_premature_aging1.85205968
25MP0003941_abnormal_skin_development1.81503453
26MP0003195_calcinosis1.79781950
27MP0005330_cardiomyopathy1.79779745
28MP0005379_endocrine/exocrine_gland_phen1.78347714
29MP0006036_abnormal_mitochondrial_physio1.77945141
30MP0000350_abnormal_cell_proliferation1.77121697
31MP0008007_abnormal_cellular_replicative1.76695428
32MP0005360_urolithiasis1.69191505
33MP0005365_abnormal_bile_salt1.64411654
34MP0005408_hypopigmentation1.62960400
35MP0008877_abnormal_DNA_methylation1.59991629
36MP0000358_abnormal_cell_content/1.58764404
37MP0006035_abnormal_mitochondrial_morpho1.56371846
38MP0001697_abnormal_embryo_size1.53403346
39MP0005332_abnormal_amino_acid1.45068477
40MP0002269_muscular_atrophy1.43861402
41MP0005085_abnormal_gallbladder_physiolo1.42529128
42MP0001672_abnormal_embryogenesis/_devel1.40469791
43MP0005380_embryogenesis_phenotype1.40469791
44MP0009333_abnormal_splenocyte_physiolog1.39537904
45MP0002080_prenatal_lethality1.37787571
46MP0005058_abnormal_lysosome_morphology1.34080224
47MP0000751_myopathy1.33538007
48MP0008875_abnormal_xenobiotic_pharmacok1.31628054
49MP0010030_abnormal_orbit_morphology1.31486314
50MP0001727_abnormal_embryo_implantation1.30630270
51MP0004133_heterotaxia1.29338122
52MP0000747_muscle_weakness1.29057429
53MP0001661_extended_life_span1.27731596
54MP0005670_abnormal_white_adipose1.24309000
55MP0005075_abnormal_melanosome_morpholog1.22953557
56MP0010307_abnormal_tumor_latency1.22348129
57MP0005395_other_phenotype1.21930924
58MP0001764_abnormal_homeostasis1.21727802
59MP0009697_abnormal_copulation1.20560837
60MP0003656_abnormal_erythrocyte_physiolo1.20179594
61MP0003984_embryonic_growth_retardation1.19546778
62MP0000013_abnormal_adipose_tissue1.19416433
63MP0001542_abnormal_bone_strength1.16429779
64MP0002088_abnormal_embryonic_growth/wei1.16027117
65MP0002085_abnormal_embryonic_tissue1.14982564
66MP0000313_abnormal_cell_death1.12592558
67MP0002210_abnormal_sex_determination1.10803808
68MP0000003_abnormal_adipose_tissue1.10293203
69MP0005266_abnormal_metabolism1.09506202
70MP0008995_early_reproductive_senescence1.07447762
71MP0002653_abnormal_ependyma_morphology1.05058185
72MP0003221_abnormal_cardiomyocyte_apopto1.04848365
73MP0003890_abnormal_embryonic-extraembry1.04652143
74MP0003121_genomic_imprinting1.04271226
75MP0004145_abnormal_muscle_electrophysio1.01710501
76MP0003136_yellow_coat_color1.01452260
77MP0001145_abnormal_male_reproductive1.01021351
78MP0002160_abnormal_reproductive_system1.00958597
79MP0005083_abnormal_biliary_tract1.00343346
80MP0001944_abnormal_pancreas_morphology1.00080588
81MP0001293_anophthalmia1.00040074
82MP0002084_abnormal_developmental_patter0.98903870
83MP0003283_abnormal_digestive_organ0.98044476
84MP0003646_muscle_fatigue0.97808527
85MP0001929_abnormal_gametogenesis0.97304622
86MP0002102_abnormal_ear_morphology0.95670767
87MP0003315_abnormal_perineum_morphology0.93493848
88MP0002090_abnormal_vision0.92291647
89MP0002163_abnormal_gland_morphology0.92179555
90MP0000678_abnormal_parathyroid_gland0.91754039
91MP0000759_abnormal_skeletal_muscle0.91395532
92MP0002019_abnormal_tumor_incidence0.90130789
93MP0000653_abnormal_sex_gland0.89987218
94MP0004036_abnormal_muscle_relaxation0.89606950
95MP0005384_cellular_phenotype0.89593567
96MP0005389_reproductive_system_phenotype0.88238895
97MP0005319_abnormal_enzyme/_coenzyme0.87880834
98MP0005501_abnormal_skin_physiology0.87696342
99MP0001905_abnormal_dopamine_level0.87310513
100MP0003011_delayed_dark_adaptation0.86693484
101MP0002132_abnormal_respiratory_system0.86676126
102MP0004197_abnormal_fetal_growth/weight/0.85728857
103MP0009780_abnormal_chondrocyte_physiolo0.84458662
104MP0005376_homeostasis/metabolism_phenot0.83641839
105MP0009672_abnormal_birth_weight0.83092962
106MP0002693_abnormal_pancreas_physiology0.82740049
107MP0005220_abnormal_exocrine_pancreas0.82496631
108MP0002822_catalepsy0.82188374
109MP0003119_abnormal_digestive_system0.81172278
110MP0004264_abnormal_extraembryonic_tissu0.78809171
111MP0002086_abnormal_extraembryonic_tissu0.77169680
112MP0002106_abnormal_muscle_physiology0.76962540
113MP0003937_abnormal_limbs/digits/tail_de0.76611914
114MP0002060_abnormal_skin_morphology0.76293781
115MP0001881_abnormal_mammary_gland0.75346872
116MP0005636_abnormal_mineral_homeostasis0.75171678
117MP0002938_white_spotting0.74171894
118MP0002111_abnormal_tail_morphology0.73922869
119MP0000598_abnormal_liver_morphology0.73861719
120MP0005645_abnormal_hypothalamus_physiol0.73852404
121MP0001346_abnormal_lacrimal_gland0.73014737
122MP0001243_abnormal_dermal_layer0.72908104
123MP0006072_abnormal_retinal_apoptosis0.72737909
124MP0002876_abnormal_thyroid_physiology0.70861408
125MP0004087_abnormal_muscle_fiber0.70380818
126MP0000609_abnormal_liver_physiology0.69723067
127MP0005621_abnormal_cell_physiology0.69380561
128MP0003950_abnormal_plasma_membrane0.69112386
129MP0000750_abnormal_muscle_regeneration0.68593616
130MP0004147_increased_porphyrin_level0.68392830
131MP0002254_reproductive_system_inflammat0.67250272
132MP0004043_abnormal_pH_regulation0.67232677
133MP0002796_impaired_skin_barrier0.66162757
134MP0004215_abnormal_myocardial_fiber0.65700454
135MP0001756_abnormal_urination0.64165105
136MP0009643_abnormal_urine_homeostasis0.64154584
137MP0001666_abnormal_nutrient_absorption0.62147450
138MP0001119_abnormal_female_reproductive0.61422062
139MP0002161_abnormal_fertility/fecundity0.57922939
140MP0004019_abnormal_vitamin_homeostasis0.56653881
141MP0002751_abnormal_autonomic_nervous0.55403334
142MP0008873_increased_physiological_sensi0.55326633
143MP0006292_abnormal_olfactory_placode0.54046376
144MP0003936_abnormal_reproductive_system0.51924277

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.54747592
2Birth length less than 3rd percentile (HP:0003561)4.40969098
3Abnormality of glycolysis (HP:0004366)4.40699122
4Increased serum pyruvate (HP:0003542)4.40699122
5Breast hypoplasia (HP:0003187)4.22480245
6Carpal bone hypoplasia (HP:0001498)4.13516371
7Acute necrotizing encephalopathy (HP:0006965)3.83944007
8Increased intramyocellular lipid droplets (HP:0012240)3.74268156
9Acute encephalopathy (HP:0006846)3.61838369
10Abnormal mitochondria in muscle tissue (HP:0008316)3.44533132
11Hyperglycinemia (HP:0002154)3.42981133
12Rough bone trabeculation (HP:0100670)3.42876133
13Mitochondrial inheritance (HP:0001427)3.31068948
14Increased muscle lipid content (HP:0009058)3.25927625
15Hepatocellular necrosis (HP:0001404)3.15850709
16Irregular epiphyses (HP:0010582)3.14949614
17Abnormality of cells of the erythroid lineage (HP:0012130)3.12032099
18Increased CSF lactate (HP:0002490)3.11441914
19Degeneration of anterior horn cells (HP:0002398)3.03847716
20Abnormality of the anterior horn cell (HP:0006802)3.03847716
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.00339804
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98907394
23CNS hypomyelination (HP:0003429)2.92422096
24Secondary amenorrhea (HP:0000869)2.92275860
25Hypoglycemic coma (HP:0001325)2.90804826
26Progressive macrocephaly (HP:0004481)2.87871770
27Cerebral edema (HP:0002181)2.87869765
28Testicular atrophy (HP:0000029)2.83902685
293-Methylglutaconic aciduria (HP:0003535)2.82073346
30CNS demyelination (HP:0007305)2.80693393
31Macrocytic anemia (HP:0001972)2.78431561
32Increased serum lactate (HP:0002151)2.76767774
33Type I transferrin isoform profile (HP:0003642)2.76158128
34Hepatic necrosis (HP:0002605)2.74819395
35Abnormal number of erythroid precursors (HP:0012131)2.74003034
36Hypokinesia (HP:0002375)2.73972676
37Abnormality of the labia minora (HP:0012880)2.72659739
38Oral leukoplakia (HP:0002745)2.71245369
39Impulsivity (HP:0100710)2.70453996
40Hypobetalipoproteinemia (HP:0003563)2.70386812
41Abnormal trabecular bone morphology (HP:0100671)2.67512264
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67442888
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67442888
44Lethargy (HP:0001254)2.57055881
45Rhabdomyolysis (HP:0003201)2.56380104
46Abnormality of glycine metabolism (HP:0010895)2.54778620
47Abnormality of serine family amino acid metabolism (HP:0010894)2.54778620
48Nemaline bodies (HP:0003798)2.52869709
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.52737625
50Hyperinsulinemic hypoglycemia (HP:0000825)2.51201086
51Reticulocytopenia (HP:0001896)2.51196837
52Absent radius (HP:0003974)2.49378804
53Megaloblastic anemia (HP:0001889)2.48911186
54Abnormal gallbladder physiology (HP:0012438)2.48089695
55Cholecystitis (HP:0001082)2.48089695
56Hyperglycinuria (HP:0003108)2.47812003
57Multiple enchondromatosis (HP:0005701)2.47196502
58Abnormality of serum amino acid levels (HP:0003112)2.46795057
59Abnormal protein glycosylation (HP:0012346)2.46455939
60Abnormal glycosylation (HP:0012345)2.46455939
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46455939
62Abnormal protein N-linked glycosylation (HP:0012347)2.46455939
63Ragged-red muscle fibers (HP:0003200)2.45693913
64Leukodystrophy (HP:0002415)2.45030873
65Premature ovarian failure (HP:0008209)2.43793211
66Trismus (HP:0000211)2.43087784
67Lactic acidosis (HP:0003128)2.42984118
68Respiratory failure (HP:0002878)2.41505636
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41456847
70Progressive muscle weakness (HP:0003323)2.38345602
71Increased hepatocellular lipid droplets (HP:0006565)2.36975513
72Patellar aplasia (HP:0006443)2.36491532
73Gout (HP:0001997)2.33288363
74Generalized aminoaciduria (HP:0002909)2.33066854
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.32072133
76Absent epiphyses (HP:0010577)2.32072133
77Spastic paraparesis (HP:0002313)2.31001533
78Lipid accumulation in hepatocytes (HP:0006561)2.30822863
79Postnatal microcephaly (HP:0005484)2.30668124
80Aplasia involving forearm bones (HP:0009822)2.29771801
81Absent forearm bone (HP:0003953)2.29771801
82Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27850541
83Reduced antithrombin III activity (HP:0001976)2.27561895
84Exercise-induced muscle cramps (HP:0003710)2.26823141
85Small epiphyses (HP:0010585)2.24701482
86Muscle fiber inclusion bodies (HP:0100299)2.23767147
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.23734077
88Prolonged neonatal jaundice (HP:0006579)2.22834721
89Aplasia/Hypoplasia of the patella (HP:0006498)2.22380172
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21378714
91Emotional lability (HP:0000712)2.19800319
92Microretrognathia (HP:0000308)2.19716258
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19107379
94Renal Fanconi syndrome (HP:0001994)2.16100066
95Delusions (HP:0000746)2.16035267
96Hypoglycemic seizures (HP:0002173)2.14895451
97Myoglobinuria (HP:0002913)2.10517060
98Ketoacidosis (HP:0001993)2.10444499
99Upper limb muscle weakness (HP:0003484)2.10426557
100Exercise intolerance (HP:0003546)2.10395890
101Personality changes (HP:0000751)2.06337813
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05375750
103Dicarboxylic aciduria (HP:0003215)2.05375750
104Microvesicular hepatic steatosis (HP:0001414)2.03751328
105Abnormality of the umbilical cord (HP:0010881)2.03633630
106Aplastic anemia (HP:0001915)2.01808535
107Optic disc pallor (HP:0000543)2.00225247
108Abnormality of renal resorption (HP:0011038)2.00157425
109Abnormality of pyrimidine metabolism (HP:0004353)1.99881920
110Methylmalonic aciduria (HP:0012120)1.99762262
111Horseshoe kidney (HP:0000085)1.97995601
112Dysautonomia (HP:0002459)1.96487778
113Sparse eyelashes (HP:0000653)1.96359428
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95661543
115Abnormalities of placenta or umbilical cord (HP:0001194)1.94500300
116Death in infancy (HP:0001522)1.94118862
117Exertional dyspnea (HP:0002875)1.93208862
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92980254
119Pancytopenia (HP:0001876)1.92857558
120Abnormality of placental membranes (HP:0011409)1.92047713
121Amniotic constriction ring (HP:0009775)1.92047713
122Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90881942
123Premature graying of hair (HP:0002216)1.89669889
124Agnosia (HP:0010524)1.88010565
125Palpitations (HP:0001962)1.87965424
126Symptomatic seizures (HP:0011145)1.87917963
127Abnormality of fatty-acid metabolism (HP:0004359)1.87570749
128Poor head control (HP:0002421)1.87121004
129Abnormal gallbladder morphology (HP:0012437)1.86324865
130Stenosis of the external auditory canal (HP:0000402)1.85872719
131Ureteral duplication (HP:0000073)1.85615031
132Delayed epiphyseal ossification (HP:0002663)1.85522133
133Glossoptosis (HP:0000162)1.84956990
134Abnormality of urine glucose concentration (HP:0011016)1.83532725
135Glycosuria (HP:0003076)1.83532725
136Autoamputation (HP:0001218)1.82393657
137Hyperammonemia (HP:0001987)1.82171482
138Flat capital femoral epiphysis (HP:0003370)1.81391334
139Neoplasm of the adrenal gland (HP:0100631)1.80356792
140Septate vagina (HP:0001153)1.78431837
141Respiratory difficulties (HP:0002880)1.78302198
142Abnormality of methionine metabolism (HP:0010901)1.78122921
143Abnormality of the pancreatic islet cells (HP:0006476)1.76000619
144Abnormality of endocrine pancreas physiology (HP:0012093)1.76000619
145Exercise-induced myalgia (HP:0003738)1.73652688
146X-linked dominant inheritance (HP:0001423)1.73422210
147Methylmalonic acidemia (HP:0002912)1.73214690
148Hyperalaninemia (HP:0003348)1.73158021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.95452405
2VRK24.29567157
3WEE14.05664169
4EIF2AK13.48889492
5NME23.10939167
6STK162.96314364
7CDC72.52156616
8TESK22.44097049
9EIF2AK32.43773014
10TSSK62.40990741
11PLK42.31225416
12SRPK12.26524133
13ARAF2.05209321
14BRSK22.04331892
15PBK2.01586568
16TTK1.91486139
17NEK21.88231193
18MAP3K121.78337385
19BRAF1.77142928
20PNCK1.73253114
21PLK11.70267014
22VRK11.69478722
23BCKDK1.69406154
24TRIM281.64648463
25NEK11.62974785
26PLK31.58303969
27EPHA21.58234244
28ACVR1B1.57649991
29PASK1.53618437
30AURKA1.47403141
31MST41.43651114
32AKT31.42809732
33TLK11.35416925
34WNK31.32335423
35MKNK11.30844092
36PIM21.27439845
37PHKG11.25634938
38PHKG21.25634938
39AURKB1.20193371
40BRSK11.17903345
41OBSCN1.16759765
42BCR1.08669179
43DYRK31.08164902
44NME11.07357716
45CDK71.06442542
46SMG11.03982568
47OXSR11.03202262
48CHEK21.02602273
49DAPK11.01474399
50ERBB40.95382242
51CDK80.94504441
52CSNK1G30.92911570
53PAK10.92528693
54MUSK0.91725487
55DYRK20.90547822
56MAP3K80.90147477
57RPS6KB20.90147465
58LATS20.89494536
59LIMK10.88155462
60RPS6KA40.88151304
61PAK40.88091105
62ABL20.85967651
63TESK10.84714268
64MET0.83976921
65CCNB10.80861646
66LRRK20.79966904
67MKNK20.79588075
68TAF10.77942901
69STK390.76796266
70CSNK2A10.76592306
71ATR0.76444244
72MST1R0.76187385
73MAP4K20.73721072
74CSNK2A20.73452182
75CDK40.72713028
76CHEK10.72507561
77PDK20.72430650
78PDK30.70222716
79PDK40.70222716
80MELK0.70132856
81MYLK0.67014258
82CSNK1G10.66537418
83MAP3K110.65169763
84STK38L0.65087544
85RPS6KA50.63073959
86CDK190.61793613
87DAPK30.60857875
88AKT20.60803263
89CSNK1A1L0.58168513
90TAOK20.53939952
91MAP2K60.52787496
92STK30.51883648
93ERBB30.49413337
94ALK0.48511147
95MAP3K30.47400160
96ILK0.47396954
97PRKCI0.46488077
98CDK20.46465853
99MOS0.44530539
100MAPKAPK30.41733982
101CSNK1E0.41515926
102WNK40.40537010
103ZAK0.39025998
104STK40.37941856
105PIM10.37705940
106CLK10.37232985
107CSNK1G20.36988202
108PAK30.36352454
109EIF2AK20.34872496
110KDR0.34825529
111RAF10.34683066
112CDK10.33797473
113PRKD30.32878611
114CDK140.32738388
115FLT30.32034150
116ATM0.31323011
117SCYL20.31225666
118MAPKAPK50.30837211
119PLK20.27287143
120MAP3K90.27217999
121CDK11A0.27063064
122CDK150.27053856
123STK100.26778325
124GRK10.26455341
125CDK180.26278330
126CAMK2G0.24690541
127CAMK2D0.24626009
128IRAK30.23899021
129PIK3CG0.19495662

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42273499
2RNA polymerase_Homo sapiens_hsa030203.65862509
3Vitamin B6 metabolism_Homo sapiens_hsa007503.33486741
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17126456
5Ribosome_Homo sapiens_hsa030103.00711424
6DNA replication_Homo sapiens_hsa030302.85386468
7Mismatch repair_Homo sapiens_hsa034302.49159190
8RNA transport_Homo sapiens_hsa030132.45852639
9Protein export_Homo sapiens_hsa030602.38394909
10Pyrimidine metabolism_Homo sapiens_hsa002402.34372628
11Spliceosome_Homo sapiens_hsa030402.19384127
12One carbon pool by folate_Homo sapiens_hsa006702.08026561
13Oxidative phosphorylation_Homo sapiens_hsa001902.06732214
14Folate biosynthesis_Homo sapiens_hsa007902.05099924
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05024498
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01359570
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95676172
18Nucleotide excision repair_Homo sapiens_hsa034201.91427340
19Homologous recombination_Homo sapiens_hsa034401.76371996
20Base excision repair_Homo sapiens_hsa034101.72343541
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68005104
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.62782825
23Basal transcription factors_Homo sapiens_hsa030221.61308584
24Parkinsons disease_Homo sapiens_hsa050121.61192443
25Cell cycle_Homo sapiens_hsa041101.60096759
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.43757648
27Biosynthesis of amino acids_Homo sapiens_hsa012301.42786108
28Huntingtons disease_Homo sapiens_hsa050161.35136668
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34021638
30Steroid biosynthesis_Homo sapiens_hsa001001.29986128
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28520240
32Glutathione metabolism_Homo sapiens_hsa004801.27453426
33Purine metabolism_Homo sapiens_hsa002301.22142034
34RNA degradation_Homo sapiens_hsa030181.22039354
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.15799538
36Pentose phosphate pathway_Homo sapiens_hsa000301.07981594
37Carbon metabolism_Homo sapiens_hsa012001.07560001
38Cardiac muscle contraction_Homo sapiens_hsa042601.06762931
39Selenocompound metabolism_Homo sapiens_hsa004501.04713257
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04367374
41Arginine and proline metabolism_Homo sapiens_hsa003300.98852569
42Regulation of autophagy_Homo sapiens_hsa041400.98646088
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97951746
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97354960
45Fanconi anemia pathway_Homo sapiens_hsa034600.97295523
46Pyruvate metabolism_Homo sapiens_hsa006200.96265924
47N-Glycan biosynthesis_Homo sapiens_hsa005100.94612133
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91763432
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91379096
50Alzheimers disease_Homo sapiens_hsa050100.89822697
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89787862
52Collecting duct acid secretion_Homo sapiens_hsa049660.88345959
53Epstein-Barr virus infection_Homo sapiens_hsa051690.85633873
54Fatty acid elongation_Homo sapiens_hsa000620.83254040
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82048862
56Galactose metabolism_Homo sapiens_hsa000520.81378263
57Non-homologous end-joining_Homo sapiens_hsa034500.80361654
58Metabolic pathways_Homo sapiens_hsa011000.79648690
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78063265
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77183865
61p53 signaling pathway_Homo sapiens_hsa041150.75890029
62Sulfur relay system_Homo sapiens_hsa041220.75807788
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75186635
64Fatty acid metabolism_Homo sapiens_hsa012120.74850400
65mRNA surveillance pathway_Homo sapiens_hsa030150.72569768
66Fructose and mannose metabolism_Homo sapiens_hsa000510.71440231
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71340155
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70284270
69Tyrosine metabolism_Homo sapiens_hsa003500.69229988
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.68788839
71Peroxisome_Homo sapiens_hsa041460.68327697
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.67962876
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62056830
74Phenylalanine metabolism_Homo sapiens_hsa003600.62041685
75Vibrio cholerae infection_Homo sapiens_hsa051100.59808115
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59752943
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59658593
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58248225
79Vitamin digestion and absorption_Homo sapiens_hsa049770.56480471
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55217115
81Systemic lupus erythematosus_Homo sapiens_hsa053220.55046587
82Fatty acid degradation_Homo sapiens_hsa000710.54980589
83Histidine metabolism_Homo sapiens_hsa003400.54638674
84Butanoate metabolism_Homo sapiens_hsa006500.54336696
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52803516
86Chemical carcinogenesis_Homo sapiens_hsa052040.52586468
87Oocyte meiosis_Homo sapiens_hsa041140.49610594
88Linoleic acid metabolism_Homo sapiens_hsa005910.48963739
89Propanoate metabolism_Homo sapiens_hsa006400.46393803
90Sulfur metabolism_Homo sapiens_hsa009200.46220095
91Arginine biosynthesis_Homo sapiens_hsa002200.45773771
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44540255
93Retinol metabolism_Homo sapiens_hsa008300.38488626
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37757307
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37248298
96beta-Alanine metabolism_Homo sapiens_hsa004100.36366064
97Arachidonic acid metabolism_Homo sapiens_hsa005900.35945163
98Rheumatoid arthritis_Homo sapiens_hsa053230.33161610
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32766284
100Tryptophan metabolism_Homo sapiens_hsa003800.31328441
101Viral carcinogenesis_Homo sapiens_hsa052030.31008951
102Lysosome_Homo sapiens_hsa041420.30998097
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30916850
104Antigen processing and presentation_Homo sapiens_hsa046120.28138145
105Fat digestion and absorption_Homo sapiens_hsa049750.26757287
106Phagosome_Homo sapiens_hsa041450.25537924
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.23588517
108Starch and sucrose metabolism_Homo sapiens_hsa005000.13692605
109Other glycan degradation_Homo sapiens_hsa005110.11021737
110Circadian rhythm_Homo sapiens_hsa047100.09996992
111Synaptic vesicle cycle_Homo sapiens_hsa047210.08549063
112Alcoholism_Homo sapiens_hsa050340.07255809
113Sphingolipid metabolism_Homo sapiens_hsa006000.06532471

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