HBA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* oxygen transport (GO:0015671)6.28426861
2negative regulation of cell killing (GO:0031342)6.07714636
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.07714636
4positive regulation by symbiont of host defense response (GO:0052509)5.70186232
5modulation by symbiont of host defense response (GO:0052031)5.70186232
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.70186232
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.70186232
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.70186232
9modulation by symbiont of host immune response (GO:0052553)5.70186232
10neutrophil activation involved in immune response (GO:0002283)5.58564758
11positive regulation of gamma-delta T cell activation (GO:0046645)5.47855875
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.34780914
13detection of other organism (GO:0098543)5.32447179
14detection of bacterium (GO:0016045)5.31323341
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.18742265
16* gas transport (GO:0015669)5.02921873
17antigen processing and presentation of endogenous antigen (GO:0019883)4.98152081
18response to peptidoglycan (GO:0032494)4.90222141
19regulation of B cell receptor signaling pathway (GO:0050855)4.74187170
20neutrophil activation (GO:0042119)4.67349480
21macrophage activation involved in immune response (GO:0002281)4.59833450
22response to interleukin-15 (GO:0070672)4.59339890
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58221294
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.34954808
25respiratory burst (GO:0045730)4.30045182
26detection of external biotic stimulus (GO:0098581)4.29482122
27cellular extravasation (GO:0045123)4.28779074
28cellular response to interleukin-15 (GO:0071350)4.27693672
29granulocyte activation (GO:0036230)4.20310545
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.18837293
31leukocyte aggregation (GO:0070486)4.08736879
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.06307771
33response to host immune response (GO:0052572)4.06307771
34negative regulation of interleukin-12 production (GO:0032695)4.03474215
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.02253226
36leukocyte migration involved in inflammatory response (GO:0002523)3.94983597
37neutrophil mediated immunity (GO:0002446)3.90389057
38regulation of gamma-delta T cell activation (GO:0046643)3.86252974
39negative regulation of leukocyte mediated immunity (GO:0002704)3.83767318
40negative regulation of erythrocyte differentiation (GO:0045647)3.83451215
41negative regulation of phagocytosis (GO:0050765)3.80701992
42microglial cell activation (GO:0001774)3.78480504
43cellular response to type I interferon (GO:0071357)3.75212114
44type I interferon signaling pathway (GO:0060337)3.75212114
45response to type I interferon (GO:0034340)3.74301278
46response to host (GO:0075136)3.73730347
47response to host defenses (GO:0052200)3.73730347
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73730347
49negative regulation of T cell mediated immunity (GO:0002710)3.70808913
50regulation of interferon-beta biosynthetic process (GO:0045357)3.70416393
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69893013
52detection of biotic stimulus (GO:0009595)3.69769303
53regulation of mast cell degranulation (GO:0043304)3.68776695
54detection of molecule of bacterial origin (GO:0032490)3.68127001
55immunoglobulin mediated immune response (GO:0016064)3.67799759
56myeloid cell activation involved in immune response (GO:0002275)3.58607000
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.53403244
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48150123
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44821603
60regulation of gamma-delta T cell differentiation (GO:0045586)3.39546348
61regulation of mast cell activation involved in immune response (GO:0033006)3.38661112
62leukocyte degranulation (GO:0043299)3.37474253
63production of molecular mediator involved in inflammatory response (GO:0002532)3.35931755
64macrophage activation (GO:0042116)3.34754798
65regulation of leukocyte degranulation (GO:0043300)3.30735750
66B cell receptor signaling pathway (GO:0050853)3.29876638
67response to interferon-alpha (GO:0035455)3.29600989
68myeloid leukocyte mediated immunity (GO:0002444)3.29102906
69regulation of B cell differentiation (GO:0045577)3.28610832
70germinal center formation (GO:0002467)3.17093332
71negative regulation of interleukin-6 production (GO:0032715)3.15465950
72positive regulation of mast cell activation (GO:0033005)3.14662858
73positive regulation of B cell differentiation (GO:0045579)3.13195417
74negative regulation of T-helper cell differentiation (GO:0045623)3.12616546
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.12616546
76regulation of T cell tolerance induction (GO:0002664)3.11751327
77regulation of mast cell activation (GO:0033003)3.10546663
78response to muramyl dipeptide (GO:0032495)3.10335715
79regulation of T-helper 2 cell differentiation (GO:0045628)3.09657228
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06194077
81negative regulation of type 2 immune response (GO:0002829)3.06154605
82positive regulation of granulocyte differentiation (GO:0030854)3.04832728
83dendritic cell migration (GO:0036336)3.01700046
84tolerance induction (GO:0002507)2.99933637
85negative regulation of cytokine production involved in immune response (GO:0002719)2.99280672
86regulation of tolerance induction (GO:0002643)2.98854425
87dendritic cell chemotaxis (GO:0002407)2.96114691
88negative thymic T cell selection (GO:0045060)2.96097186
89positive thymic T cell selection (GO:0045059)2.96020907
90regulation of regulated secretory pathway (GO:1903305)2.93361181
91activated T cell proliferation (GO:0050798)2.91164791
92B cell mediated immunity (GO:0019724)2.89939326
93negative T cell selection (GO:0043383)2.88669657
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.86387309
95negative regulation of alpha-beta T cell activation (GO:0046636)2.84751829
96regulation of platelet aggregation (GO:0090330)2.84579243
97negative regulation of innate immune response (GO:0045824)2.81782305
98negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.81585459
99defense response to protozoan (GO:0042832)2.80225461
100interferon-gamma-mediated signaling pathway (GO:0060333)2.79985485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89492066
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.72830036
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69615616
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.46951564
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.44049205
6VDR_21846776_ChIP-Seq_THP-1_Human3.10124277
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89747103
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85050448
9VDR_24763502_ChIP-Seq_THP-1_Human2.80117245
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72444573
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.72327455
12SCL_19346495_ChIP-Seq_HPC-7_Human2.67456058
13SPI1_23547873_ChIP-Seq_NB4_Human2.64652478
14SPI1_23127762_ChIP-Seq_K562_Human2.61115841
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60977423
16GATA1_22025678_ChIP-Seq_K562_Human2.60812808
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58954791
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56958868
19MAF_26560356_Chip-Seq_TH1_Human2.56782506
20MYC_22102868_ChIP-Seq_BL_Human2.48189791
21RUNX_20019798_ChIP-Seq_JUKART_Human2.47861172
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41563715
23UTX_26944678_Chip-Seq_JUKART_Human2.37965073
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.37817122
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.32230668
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29079519
27TCF7_22412390_ChIP-Seq_EML_Mouse2.27304881
28GATA1_19941826_ChIP-Seq_K562_Human2.25966920
29MYB_26560356_Chip-Seq_TH2_Human2.23811799
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19844928
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17097728
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16695871
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12373114
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06568970
35KDM2B_26808549_Chip-Seq_DND41_Human2.05939309
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03718208
37MYB_26560356_Chip-Seq_TH1_Human2.02325805
38GATA1_19941827_ChIP-Seq_MEL_Mouse2.00745826
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99596337
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96540774
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95573350
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.94708671
43MAF_26560356_Chip-Seq_TH2_Human1.94184357
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.81044693
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80080943
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76294034
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72232849
48GATA3_27048872_Chip-Seq_THYMUS_Human1.66241792
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59807976
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56784138
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.55912939
52GATA2_19941826_ChIP-Seq_K562_Human1.54220431
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52431571
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51884962
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51669190
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47639633
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47485283
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47392328
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47366001
60LXR_22292898_ChIP-Seq_THP-1_Human1.46891632
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45401257
62VDR_24787735_ChIP-Seq_THP-1_Human1.44468295
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42384773
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38091091
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38010081
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37710739
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.37661338
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34797141
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34492202
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33725551
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32994906
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28492016
73BCL6_27268052_Chip-Seq_Bcells_Human1.26550971
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24824652
75BCOR_27268052_Chip-Seq_Bcells_Human1.24659245
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23316791
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21340197
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19133656
79NCOR1_26117541_ChIP-Seq_K562_Human1.18190803
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17503085
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16518718
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16221468
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15321158
84PU_27001747_Chip-Seq_BMDM_Mouse1.14420040
85GATA3_26560356_Chip-Seq_TH2_Human1.13930013
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09783589
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08983203
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06945033
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.04767220
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03533442
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02635297
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00600155
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98453904
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96895620
95* GATA2_21666600_ChIP-Seq_HMVEC_Human0.95840115
96* ELF1_20517297_ChIP-Seq_JURKAT_Human0.94934257
97P68_20966046_ChIP-Seq_HELA_Human0.94359643
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93954325
99SPI1_20517297_ChIP-Seq_HL60_Human0.93005340
100KDM2B_26808549_Chip-Seq_K562_Human0.91465423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.85990280
2MP0003436_decreased_susceptibility_to4.33862901
3MP0003303_peritoneal_inflammation3.79911476
4MP0001835_abnormal_antigen_presentation3.24729002
5MP0002419_abnormal_innate_immunity3.14328140
6MP0005025_abnormal_response_to2.94776308
7MP0009785_altered_susceptibility_to2.82179872
8MP0001790_abnormal_immune_system2.79125218
9MP0005387_immune_system_phenotype2.79125218
10MP0000685_abnormal_immune_system2.74853805
11MP0001800_abnormal_humoral_immune2.70385144
12MP0005000_abnormal_immune_tolerance2.62655948
13MP0005671_abnormal_response_to2.55513570
14MP0003191_abnormal_cellular_cholesterol2.55020911
15MP0002420_abnormal_adaptive_immunity2.50409887
16MP0003300_gastrointestinal_ulcer2.48807128
17MP0001819_abnormal_immune_cell2.47215415
18MP0002723_abnormal_immune_serum2.42653211
19MP0003656_abnormal_erythrocyte_physiolo2.38563956
20MP0002452_abnormal_antigen_presenting2.28129436
21MP0003763_abnormal_thymus_physiology2.25561455
22MP0006082_CNS_inflammation2.23492192
23MP0008260_abnormal_autophagy2.20006162
24MP0002132_abnormal_respiratory_system2.18993498
25MP0005464_abnormal_platelet_physiology2.17366561
26MP0002405_respiratory_system_inflammati2.15057550
27MP0002398_abnormal_bone_marrow2.09372413
28MP0001533_abnormal_skeleton_physiology2.08167259
29MP0009278_abnormal_bone_marrow1.98923926
30MP0002396_abnormal_hematopoietic_system1.95104106
31MP0002148_abnormal_hypersensitivity_rea1.93239423
32MP0000716_abnormal_immune_system1.88367703
33MP0005083_abnormal_biliary_tract1.84575734
34MP0003866_abnormal_defecation1.73941402
35MP0010155_abnormal_intestine_physiology1.73741570
36MP0003828_pulmonary_edema1.72355034
37MP0002722_abnormal_immune_system1.71939287
38MP0000689_abnormal_spleen_morphology1.70147694
39MP0001545_abnormal_hematopoietic_system1.69266845
40MP0005397_hematopoietic_system_phenotyp1.69266845
41MP0003045_fibrosis1.68030157
42MP0000465_gastrointestinal_hemorrhage1.64557932
43MP0009333_abnormal_splenocyte_physiolog1.64070285
44MP0003172_abnormal_lysosome_physiology1.62000286
45MP0001845_abnormal_inflammatory_respons1.60775030
46MP0002277_abnormal_respiratory_mucosa1.60773872
47MP0003183_abnormal_peptide_metabolism1.59256326
48MP0000703_abnormal_thymus_morphology1.59015032
49MP0002429_abnormal_blood_cell1.58266919
50MP0004381_abnormal_hair_follicle1.50296446
51MP0004947_skin_inflammation1.49961149
52MP0009764_decreased_sensitivity_to1.41831361
53MP0008469_abnormal_protein_level1.41535488
54MP0001851_eye_inflammation1.37651103
55MP0005377_hearing/vestibular/ear_phenot1.29034774
56MP0003878_abnormal_ear_physiology1.29034774
57MP0005451_abnormal_body_composition1.26809796
58MP0000858_altered_metastatic_potential1.23990078
59MP0005310_abnormal_salivary_gland1.21424648
60MP0004883_abnormal_blood_vessel1.18949000
61MP0004147_increased_porphyrin_level1.12147048
62MP0004510_myositis1.10489493
63MP0005075_abnormal_melanosome_morpholog1.06576811
64MP0003075_altered_response_to0.99284962
65MP0000490_abnormal_crypts_of0.99158231
66MP0002998_abnormal_bone_remodeling0.97987163
67MP0005164_abnormal_response_to0.94426991
68MP0004808_abnormal_hematopoietic_stem0.93576557
69MP0001873_stomach_inflammation0.92296296
70MP0009763_increased_sensitivity_to0.89166572
71MP0001663_abnormal_digestive_system0.89103474
72MP0003690_abnormal_glial_cell0.88973971
73MP0000343_altered_response_to0.84532048
74MP0005390_skeleton_phenotype0.81697372
75MP0002166_altered_tumor_susceptibility0.80052582
76MP0001986_abnormal_taste_sensitivity0.80045439
77MP0004130_abnormal_muscle_cell0.77076360
78MP0009765_abnormal_xenobiotic_induced0.74147582
79MP0003806_abnormal_nucleotide_metabolis0.72504388
80MP0005166_decreased_susceptibility_to0.71456604
81MP0000015_abnormal_ear_pigmentation0.68554102
82MP0005319_abnormal_enzyme/_coenzyme0.68240123
83MP0003795_abnormal_bone_structure0.67842049
84MP0004858_abnormal_nervous_system0.63734400
85MP0002653_abnormal_ependyma_morphology0.63035035
86MP0002928_abnormal_bile_duct0.62967156
87MP0008004_abnormal_stomach_pH0.62445447
88MP0008874_decreased_physiological_sensi0.61038733
89MP0003448_altered_tumor_morphology0.60071736
90MP0002168_other_aberrant_phenotype0.59149929
91MP0000249_abnormal_blood_vessel0.59109732
92MP0005058_abnormal_lysosome_morphology0.58030109
93MP0002933_joint_inflammation0.57908427
94MP0003221_abnormal_cardiomyocyte_apopto0.55883965
95MP0003879_abnormal_hair_cell0.55372739
96MP0002138_abnormal_hepatobiliary_system0.51981779
97MP0002332_abnormal_exercise_endurance0.51122225
98MP0005248_abnormal_Harderian_gland0.50922119
99MP0000609_abnormal_liver_physiology0.50775494
100MP0005076_abnormal_cell_differentiation0.50404285

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.68541094
2* Abnormality of the heme biosynthetic pathway (HP:0010472)6.52670035
3* Hypochromic anemia (HP:0001931)6.29067712
4Recurrent abscess formation (HP:0002722)5.66104016
5Recurrent bacterial skin infections (HP:0005406)5.50429971
6Myositis (HP:0100614)5.27759480
7Abnormality of macrophages (HP:0004311)5.00076977
8* Microcytic anemia (HP:0001935)4.89861664
9* Abnormal hemoglobin (HP:0011902)4.86043881
10Polycythemia (HP:0001901)4.82988268
11Recurrent gram-negative bacterial infections (HP:0005420)4.82685484
12Orchitis (HP:0100796)4.77497951
13Stomatitis (HP:0010280)4.74532808
14Elevated erythrocyte sedimentation rate (HP:0003565)4.42747543
15Retrobulbar optic neuritis (HP:0100654)4.25090240
16Optic neuritis (HP:0100653)4.25090240
17Obstructive lung disease (HP:0006536)4.17056186
18Chronic obstructive pulmonary disease (HP:0006510)4.17056186
19Gastrointestinal infarctions (HP:0005244)4.03163038
20Abnormal delayed hypersensitivity skin test (HP:0002963)4.03103859
21Prolonged bleeding time (HP:0003010)3.89095715
22Recurrent fungal infections (HP:0002841)3.82945944
23Mediastinal lymphadenopathy (HP:0100721)3.81907279
24Increased IgE level (HP:0003212)3.77123838
25Spontaneous hematomas (HP:0007420)3.72033095
26Meningitis (HP:0001287)3.70143855
27Urticaria (HP:0001025)3.62713657
28Recurrent skin infections (HP:0001581)3.57819724
29Gingivitis (HP:0000230)3.44787475
30Encephalitis (HP:0002383)3.37521413
31Keratoconjunctivitis sicca (HP:0001097)3.26496822
32Cellulitis (HP:0100658)3.26405920
33Recurrent cutaneous fungal infections (HP:0011370)3.10952567
34Chronic mucocutaneous candidiasis (HP:0002728)3.10952567
35Vasculitis (HP:0002633)3.09616749
36Episodic fever (HP:0001954)3.06930754
37Keratoconjunctivitis (HP:0001096)3.02161548
38* Toxemia of pregnancy (HP:0100603)3.00286436
39Osteomyelitis (HP:0002754)2.98658275
40Chest pain (HP:0100749)2.95782798
41Petechiae (HP:0000967)2.92313406
42Gingival bleeding (HP:0000225)2.87286179
43Epistaxis (HP:0000421)2.83585394
44Pustule (HP:0200039)2.80292768
45Abnormality of iron homeostasis (HP:0011031)2.78796147
46Peritonitis (HP:0002586)2.77518694
47Inflammation of the large intestine (HP:0002037)2.71136712
48Anorexia (HP:0002039)2.68517969
49Gastrointestinal inflammation (HP:0004386)2.64303704
50Leukocytosis (HP:0001974)2.57856828
51Poikilocytosis (HP:0004447)2.50498065
52Pulmonary infiltrates (HP:0002113)2.49381372
53Panhypogammaglobulinemia (HP:0003139)2.46638281
54Hemoptysis (HP:0002105)2.46014385
55T lymphocytopenia (HP:0005403)2.42600825
56Increased IgM level (HP:0003496)2.42410658
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40979143
58Abnormal platelet volume (HP:0011876)2.40748477
59Granulocytopenia (HP:0001913)2.38332952
60Abnormality of T cell number (HP:0011839)2.35464088
61Recurrent viral infections (HP:0004429)2.34483094
62Abnormality of T cells (HP:0002843)2.34325159
63Abnormality of transition element cation homeostasis (HP:0011030)2.29536492
64Pulmonary embolism (HP:0002204)2.29431604
65Arterial thrombosis (HP:0004420)2.22694569
66Slow saccadic eye movements (HP:0000514)2.20174617
67Abnormality of T cell physiology (HP:0011840)2.20108564
68Sepsis (HP:0100806)2.18498593
69Amyloidosis (HP:0011034)2.18131967
70Cholelithiasis (HP:0001081)2.14719786
71Hypergammaglobulinemia (HP:0010702)2.14025558
72Purpura (HP:0000979)2.13217487
73Lymphopenia (HP:0001888)2.10081993
74Abnormality of the peritoneum (HP:0002585)2.07401699
75Skin ulcer (HP:0200042)2.07381241
76Abnormality of the pleura (HP:0002103)2.06464703
77* Abnormality of the pericardium (HP:0001697)2.04465812
78* Hypochromic microcytic anemia (HP:0004840)10.0584536
79Metaphyseal cupping (HP:0003021)1.96694876
80Abnormality of cells of the lymphoid lineage (HP:0012140)1.95464588
81Hepatosplenomegaly (HP:0001433)1.94565364
82Abnormality of the fingertips (HP:0001211)1.93637292
83Thrombophlebitis (HP:0004418)1.93132663
84IgM deficiency (HP:0002850)1.90851073
85Difficulty running (HP:0009046)1.90165500
86Increased serum ferritin (HP:0003281)1.89966189
87Abnormal gallbladder morphology (HP:0012437)1.88121036
88Glomerulopathy (HP:0100820)1.87368915
89Eosinophilia (HP:0001880)1.83831315
90Colitis (HP:0002583)1.82588149
91Acne (HP:0001061)1.79807592
92Nasal polyposis (HP:0100582)1.75695474
93Reticulocytosis (HP:0001923)1.74879209
94Vertigo (HP:0002321)1.74159883
95* Splenomegaly (HP:0001744)1.73988450
96Hypermelanotic macule (HP:0001034)1.73933058
97Viral hepatitis (HP:0006562)1.72544722
98Aseptic necrosis (HP:0010885)1.72452351
99Skin rash (HP:0000988)1.72102118
100Gangrene (HP:0100758)1.71413304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.62800234
2MAP4K13.64626532
3MAP2K33.64544724
4ERN13.14402321
5IRAK43.07106236
6TNK23.05434362
7GRK62.86313379
8PRPF4B2.60198344
9TAOK12.59880261
10BLK2.56607648
11TYK22.51507830
12FES2.48732199
13CSK2.33660605
14EPHB12.30175363
15MAP3K32.27982937
16MAP3K112.20150008
17ZAP702.03822447
18BTK1.87258585
19HCK1.81456027
20SYK1.66644201
21FGR1.66148973
22TXK1.50546468
23SIK31.50320112
24TAOK21.45423246
25JAK31.41620712
26MAP3K11.39012506
27IKBKE1.36271800
28JAK21.30730156
29LYN1.30333190
30KSR21.25604191
31MARK31.23911825
32TRIB31.23847735
33MARK21.20920429
34PRKD21.16587208
35TBK11.13621833
36LCK1.09507936
37YES11.09241786
38SIK21.07291296
39PTK61.07163226
40PTK2B1.06053980
41JAK11.05958779
42SMG11.01833495
43TAOK30.95740269
44MAP3K130.94001228
45KIT0.92935021
46ITK0.90169571
47MAP3K60.88047571
48CDK190.85011899
49CSF1R0.84520198
50TEC0.82465502
51PDK10.80426274
52HIPK20.79975847
53MAP3K70.78133968
54STK110.77847781
55MAP3K140.77324810
56MAP2K40.75793806
57STK100.75440032
58PDPK10.72116975
59TESK20.71405634
60MAPK120.70857124
61SIK10.70555634
62FYN0.66227934
63STK380.65602750
64SGK30.65140400
65DYRK1B0.64177662
66MAP3K50.62545841
67IKBKB0.60609461
68PIM10.60202571
69BMX0.59276598
70IRAK10.58700098
71LRRK20.57910125
72MATK0.55987347
73PRKCQ0.52747655
74RPS6KC10.49678832
75RPS6KL10.49678832
76EPHA30.49212358
77RET0.49022699
78MAP3K20.47569158
79MAPK70.47154490
80FGFR40.45882667
81CDC42BPA0.43811047
82SGK20.43466419
83IRAK20.42179062
84FGFR30.42149249
85RPS6KA60.41623500
86KSR10.40927441
87NLK0.40305943
88MAP2K60.39167002
89MAPKAPK20.38618470
90PRKG20.37220542
91DAPK20.36545151
92PRKCZ0.36537988
93MAP3K80.35956707
94BMPR20.35590379
95CDK120.34687076
96TGFBR20.34686148
97MAP3K100.34553455
98PIK3CG0.34492981
99RAF10.33720859
100CAMKK10.31026080

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.06978519
2* Malaria_Homo sapiens_hsa051442.89499936
3Leishmaniasis_Homo sapiens_hsa051402.77162930
4Staphylococcus aureus infection_Homo sapiens_hsa051502.50190889
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35801485
6* African trypanosomiasis_Homo sapiens_hsa051432.28322455
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.27361020
8B cell receptor signaling pathway_Homo sapiens_hsa046622.24874379
9Primary immunodeficiency_Homo sapiens_hsa053402.07631891
10Acute myeloid leukemia_Homo sapiens_hsa052212.06969420
11Tuberculosis_Homo sapiens_hsa051522.00089741
12Measles_Homo sapiens_hsa051621.92245182
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90244970
14Graft-versus-host disease_Homo sapiens_hsa053321.86189637
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85591848
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81512497
17Chemokine signaling pathway_Homo sapiens_hsa040621.79330657
18Allograft rejection_Homo sapiens_hsa053301.77434055
19Hematopoietic cell lineage_Homo sapiens_hsa046401.68636224
20Autoimmune thyroid disease_Homo sapiens_hsa053201.66787058
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66290972
22T cell receptor signaling pathway_Homo sapiens_hsa046601.64924792
23Non-small cell lung cancer_Homo sapiens_hsa052231.51096936
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50850663
25Influenza A_Homo sapiens_hsa051641.50222489
26Toxoplasmosis_Homo sapiens_hsa051451.44326848
27Herpes simplex infection_Homo sapiens_hsa051681.42485128
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.40764951
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.37623774
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.36904891
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31916029
32Pancreatic cancer_Homo sapiens_hsa052121.30309562
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26318177
34Hepatitis C_Homo sapiens_hsa051601.25935729
35Phagosome_Homo sapiens_hsa041451.25668670
36Antigen processing and presentation_Homo sapiens_hsa046121.25387671
37Platelet activation_Homo sapiens_hsa046111.25171617
38Chronic myeloid leukemia_Homo sapiens_hsa052201.25078139
39Type I diabetes mellitus_Homo sapiens_hsa049401.22367762
40Viral myocarditis_Homo sapiens_hsa054161.15399879
41Hepatitis B_Homo sapiens_hsa051611.15352901
42TNF signaling pathway_Homo sapiens_hsa046681.13611524
43Legionellosis_Homo sapiens_hsa051341.12481375
44VEGF signaling pathway_Homo sapiens_hsa043701.06492828
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97558436
46Renal cell carcinoma_Homo sapiens_hsa052110.97451941
47Shigellosis_Homo sapiens_hsa051310.92704751
48Asthma_Homo sapiens_hsa053100.92516703
49Apoptosis_Homo sapiens_hsa042100.91290793
50Endocytosis_Homo sapiens_hsa041440.90268784
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86284042
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.86117832
53Prolactin signaling pathway_Homo sapiens_hsa049170.85546533
54FoxO signaling pathway_Homo sapiens_hsa040680.85288214
55Endometrial cancer_Homo sapiens_hsa052130.84830159
56Salmonella infection_Homo sapiens_hsa051320.82908009
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82849068
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.82660617
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.82411891
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81620580
61Other glycan degradation_Homo sapiens_hsa005110.81111136
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.79941679
63Notch signaling pathway_Homo sapiens_hsa043300.79504178
64Regulation of autophagy_Homo sapiens_hsa041400.79235578
65Choline metabolism in cancer_Homo sapiens_hsa052310.77488841
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77214041
67Pertussis_Homo sapiens_hsa051330.75199364
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73777894
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.73502377
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73429586
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73117388
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.71148353
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70096658
74Colorectal cancer_Homo sapiens_hsa052100.70037286
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68756299
76Viral carcinogenesis_Homo sapiens_hsa052030.68648297
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67267270
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66212793
79Epstein-Barr virus infection_Homo sapiens_hsa051690.64642476
80GnRH signaling pathway_Homo sapiens_hsa049120.62748473
81mTOR signaling pathway_Homo sapiens_hsa041500.61720043
82Inositol phosphate metabolism_Homo sapiens_hsa005620.61391640
83HTLV-I infection_Homo sapiens_hsa051660.57243752
84HIF-1 signaling pathway_Homo sapiens_hsa040660.56453575
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56254274
86Insulin resistance_Homo sapiens_hsa049310.55891468
87Amoebiasis_Homo sapiens_hsa051460.55493746
88Rheumatoid arthritis_Homo sapiens_hsa053230.53964293
89Rap1 signaling pathway_Homo sapiens_hsa040150.53950886
90Collecting duct acid secretion_Homo sapiens_hsa049660.52416031
91MAPK signaling pathway_Homo sapiens_hsa040100.52247456
92Type II diabetes mellitus_Homo sapiens_hsa049300.51860408
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50444933
94Dorso-ventral axis formation_Homo sapiens_hsa043200.46098488
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45654579
96Glioma_Homo sapiens_hsa052140.44342272
97Thyroid cancer_Homo sapiens_hsa052160.44289282
98ErbB signaling pathway_Homo sapiens_hsa040120.43660427
99Prostate cancer_Homo sapiens_hsa052150.43604215
100Insulin signaling pathway_Homo sapiens_hsa049100.41706107

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