ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxygen transport (GO:0015671)	9.85367801
2	gas transport (GO:0015669)	9.66456288
3	porphyrin-containing compound biosynthetic process (GO:0006779)	8.38986095
4	erythrocyte maturation (GO:0043249)	7.90291047
5	tetrapyrrole biosynthetic process (GO:0033014)	7.47478728
6	erythrocyte development (GO:0048821)	7.14623709
7	porphyrin-containing compound metabolic process (GO:0006778)	6.99451840
8	heme biosynthetic process (GO:0006783)	6.71888136
9	heme metabolic process (GO:0042168)	5.53790135
10	negative regulation of erythrocyte differentiation (GO:0045647)	5.34160377
11	iron ion import (GO:0097286)	5.14869285
12	hemoglobin metabolic process (GO:0020027)	5.02613123
13	DNA topological change (GO:0006265)	4.98734660
14	nuclear pore complex assembly (GO:0051292)	4.95493252
15	definitive hemopoiesis (GO:0060216)	4.89714657
16	myeloid cell development (GO:0061515)	4.88951860
17	granulocyte differentiation (GO:0030851)	4.82439872
18	regulation of RNA export from nucleus (GO:0046831)	4.61240813
19	DNA replication checkpoint (GO:0000076)	4.41196702
20	tetrapyrrole metabolic process (GO:0033013)	4.34005716
21	nuclear pore organization (GO:0006999)	4.29605712
22	regulation of response to osmotic stress (GO:0047484)	4.26421972
23	DNA replication initiation (GO:0006270)	3.96592344
24	regulation of histone H3-K4 methylation (GO:0051569)	3.95426707
25	DNA unwinding involved in DNA replication (GO:0006268)	3.93176526
26	one-carbon compound transport (GO:0019755)	3.88264358
27	platelet formation (GO:0030220)	3.78127695
28	regulation of translational fidelity (GO:0006450)	3.77036728
29	regulation of nucleobase-containing compound transport (GO:0032239)	3.75065506
30	mitotic chromosome condensation (GO:0007076)	3.74451920
31	mitotic sister chromatid segregation (GO:0000070)	3.72796205
32	pore complex assembly (GO:0046931)	3.68758227
33	regulation of histone H3-K9 methylation (GO:0051570)	3.62745016
34	regulation of erythrocyte differentiation (GO:0045646)	3.61961484
35	proline biosynthetic process (GO:0006561)	3.60628197
36	sister chromatid segregation (GO:0000819)	3.58111811
37	mitotic nuclear envelope disassembly (GO:0007077)	3.57843345
38	megakaryocyte development (GO:0035855)	3.55867846
39	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.53740611
40	positive regulation of megakaryocyte differentiation (GO:0045654)	3.53636380
41	meiotic chromosome segregation (GO:0045132)	3.50669516
42	response to methylmercury (GO:0051597)	3.50464332
43	erythrocyte differentiation (GO:0030218)	3.41360712
44	DNA strand elongation involved in DNA replication (GO:0006271)	3.41248552
45	nuclear envelope disassembly (GO:0051081)	3.40538873
46	membrane disassembly (GO:0030397)	3.40538873
47	hematopoietic stem cell differentiation (GO:0060218)	3.36902744
48	pigment biosynthetic process (GO:0046148)	3.34880954
49	DNA strand elongation (GO:0022616)	3.34737937
50	embryonic hemopoiesis (GO:0035162)	3.29814126
51	synapsis (GO:0007129)	3.26115982
52	regulation of histone H3-K27 methylation (GO:0061085)	3.23226861
53	positive regulation of erythrocyte differentiation (GO:0045648)	3.19904472
54	negative regulation of histone methylation (GO:0031061)	3.19720296
55	diterpenoid biosynthetic process (GO:0016102)	3.18085637
56	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.13895251
57	response to lead ion (GO:0010288)	3.13044044
58	homocysteine metabolic process (GO:0050667)	3.11312832
59	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	3.10954080
60	telomere maintenance via semi-conservative replication (GO:0032201)	3.07252745
61	response to insecticide (GO:0017085)	3.06368070
62	cellular response to thyroid hormone stimulus (GO:0097067)	3.05852856
63	formation of translation preinitiation complex (GO:0001731)	3.04202804
64	chromosome segregation (GO:0007059)	3.01911841
65	protein-cofactor linkage (GO:0018065)	3.00963924
66	resolution of meiotic recombination intermediates (GO:0000712)	3.00743480
67	microtubule depolymerization (GO:0007019)	2.98015982
68	kinetochore organization (GO:0051383)	2.96599287
69	regulation of histone methylation (GO:0031060)	2.94625476
70	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.92103395
71	terpenoid biosynthetic process (GO:0016114)	2.90636785
72	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.90166959
73	positive regulation of histone methylation (GO:0031062)	2.88165537
74	potassium ion export (GO:0071435)	2.86016455
75	folic acid-containing compound biosynthetic process (GO:0009396)	2.84987584
76	response to thyroid hormone (GO:0097066)	2.81679295
77	pigment metabolic process (GO:0042440)	2.80760630
78	regulation of centriole replication (GO:0046599)	2.77391452
79	protein export from nucleus (GO:0006611)	2.72182474
80	positive regulation of granulocyte differentiation (GO:0030854)	2.72135923
81	telomere maintenance via recombination (GO:0000722)	2.68165575
82	glycine transport (GO:0015816)	2.67700155
83	protein localization to chromosome, centromeric region (GO:0071459)	2.67299701
84	tRNA aminoacylation for protein translation (GO:0006418)	2.65082807
85	deoxyribose phosphate biosynthetic process (GO:0046385)	2.62458367
86	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.62458367
87	purine nucleobase biosynthetic process (GO:0009113)	2.61590720
88	mitotic recombination (GO:0006312)	2.60429530
89	deoxyribonucleotide biosynthetic process (GO:0009263)	2.58886060
90	response to arsenic-containing substance (GO:0046685)	2.58562585
91	regulation of mitotic spindle organization (GO:0060236)	2.57222776
92	very-low-density lipoprotein particle assembly (GO:0034379)	2.57146904
93	oxidative phosphorylation (GO:0006119)	2.56572604
94	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.56559716
95	DNA synthesis involved in DNA repair (GO:0000731)	2.56144968
96	tetrahydrofolate metabolic process (GO:0046653)	2.55944159
97	tRNA aminoacylation (GO:0043039)	2.55246554
98	amino acid activation (GO:0043038)	2.55246554
99	protoporphyrinogen IX metabolic process (GO:0046501)	12.0444528
100	protoporphyrinogen IX biosynthetic process (GO:0006782)	10.1534783

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.33883186
2	GATA1_22025678_ChIP-Seq_K562_Human	5.76330889
3	GATA1_19941826_ChIP-Seq_K562_Human	4.47019173
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.14052309
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.03780142
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.28808489
7	GATA2_19941826_ChIP-Seq_K562_Human	2.92872815
8	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.80394562
9	NCOR1_26117541_ChIP-Seq_K562_Human	2.75913970
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.67436508
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.56145710
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.53624375
13	SCL_19346495_ChIP-Seq_HPC-7_Human	2.53196120
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.45553309
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14353576
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.07015558
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.04681551
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.02194018
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01397135
20	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.99324989
21	XRN2_22483619_ChIP-Seq_HELA_Human	1.86280204
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.83612760
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.83214306
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.79504142
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.75782309
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.73516423
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.69317657
28	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.65101153
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.64732291
30	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.62257625
31	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.60875301
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59708624
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59270995
34	ZNF263_19887448_ChIP-Seq_K562_Human	1.58072851
35	MYC_22102868_ChIP-Seq_BL_Human	1.57380923
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54785135
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53551763
38	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.52564460
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49860957
40	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.49300025
41	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.48291371
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.47034368
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45712265
44	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.43868176
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.42375158
46	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.39730020
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38473684
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36751861
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.35381362
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.33079296
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32646865
52	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.31504152
53	SPI1_23127762_ChIP-Seq_K562_Human	1.29359371
54	CIITA_25753668_ChIP-Seq_RAJI_Human	1.28097897
55	TFEB_21752829_ChIP-Seq_HELA_Human	1.27394966
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.27306379
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.24481831
58	AR_21909140_ChIP-Seq_LNCAP_Human	1.23777022
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.23488251
60	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.23081253
61	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21527120
62	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.19826193
63	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18287478
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17857540
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.17434003
66	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.16153151
67	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.08188253
68	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.07988014
69	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.06748815
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04835693
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04793911
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.03540738
73	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01036916
74	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.00844212
75	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00359381
76	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.00201924
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99048681
78	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.97722253
79	MAF_26560356_Chip-Seq_TH1_Human	0.96918174
80	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96211116
81	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.95869166
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95538474
83	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.93787132
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92090106
85	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.90807767
86	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.90481944
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90168587
88	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.87445221
89	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.87313509
90	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.86030837
91	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.85594972
92	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.84856966
93	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.83848491
94	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83836300
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.82881500
96	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.82683105
97	CHD1_26751641_Chip-Seq_LNCaP_Human	0.82513296
98	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.82104289
99	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.82093027
100	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.80519696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	9.97731435
2	MP0003656_abnormal_erythrocyte_physiolo	7.60364640
3	MP0005083_abnormal_biliary_tract	5.05489320
4	MP0008995_early_reproductive_senescence	3.73731717
5	MP0001545_abnormal_hematopoietic_system	3.25069635
6	MP0005397_hematopoietic_system_phenotyp	3.25069635
7	MP0003111_abnormal_nucleus_morphology	3.18583471
8	MP0004957_abnormal_blastocyst_morpholog	2.66677917
9	MP0008058_abnormal_DNA_repair	2.53312217
10	MP0010094_abnormal_chromosome_stability	2.50956628
11	MP0009697_abnormal_copulation	2.44676116
12	MP0003786_premature_aging	2.19650569
13	MP0008057_abnormal_DNA_replication	2.18939374
14	MP0005451_abnormal_body_composition	1.98290468
15	MP0003693_abnormal_embryo_hatching	1.95076119
16	MP0005464_abnormal_platelet_physiology	1.86582664
17	MP0003077_abnormal_cell_cycle	1.82494986
18	MP0006036_abnormal_mitochondrial_physio	1.79383037
19	MP0005636_abnormal_mineral_homeostasis	1.78412271
20	MP0002132_abnormal_respiratory_system	1.74927253
21	MP0009278_abnormal_bone_marrow	1.67994582
22	MP0003186_abnormal_redox_activity	1.67820222
23	MP0010307_abnormal_tumor_latency	1.48739188
24	MP0001529_abnormal_vocalization	1.47331101
25	MP0006035_abnormal_mitochondrial_morpho	1.44850879
26	MP0008932_abnormal_embryonic_tissue	1.44623689
27	MP0002396_abnormal_hematopoietic_system	1.42127778
28	MP0004145_abnormal_muscle_electrophysio	1.37212996
29	MP0001730_embryonic_growth_arrest	1.31789038
30	MP0008775_abnormal_heart_ventricle	1.29290316
31	MP0000313_abnormal_cell_death	1.28588689
32	MP0001661_extended_life_span	1.22273766
33	MP0004808_abnormal_hematopoietic_stem	1.20836100
34	MP0000678_abnormal_parathyroid_gland	1.18639277
35	MP0001697_abnormal_embryo_size	1.16264033
36	MP0008007_abnormal_cellular_replicative	1.13264900
37	MP0003718_maternal_effect	1.12044450
38	MP0000350_abnormal_cell_proliferation	1.10589091
39	MP0002080_prenatal_lethality	1.09432718
40	MP0002398_abnormal_bone_marrow	1.03701852
41	MP0002722_abnormal_immune_system	1.02871650
42	MP0002877_abnormal_melanocyte_morpholog	1.02489493
43	MP0009931_abnormal_skin_appearance	0.99978846
44	MP0002095_abnormal_skin_pigmentation	0.99767707
45	MP0000372_irregular_coat_pigmentation	0.97914220
46	MP0002086_abnormal_extraembryonic_tissu	0.96650720
47	MP0005380_embryogenesis_phenotype	0.95290732
48	MP0001672_abnormal_embryogenesis/_devel	0.95290732
49	MP0003984_embryonic_growth_retardation	0.92504243
50	MP0000703_abnormal_thymus_morphology	0.88198024
51	MP0000609_abnormal_liver_physiology	0.88170657
52	MP0001929_abnormal_gametogenesis	0.88023958
53	MP0000689_abnormal_spleen_morphology	0.87874937
54	MP0000358_abnormal_cell_content/	0.87686261
55	MP0002088_abnormal_embryonic_growth/wei	0.87663533
56	MP0002019_abnormal_tumor_incidence	0.84293471
57	MP0002210_abnormal_sex_determination	0.80928723
58	MP0005076_abnormal_cell_differentiation	0.75407829
59	MP0003806_abnormal_nucleotide_metabolis	0.73893160
60	MP0005171_absent_coat_pigmentation	0.72541559
61	MP0002429_abnormal_blood_cell	0.71873494
62	MP0008770_decreased_survivor_rate	0.70853538
63	MP0009333_abnormal_splenocyte_physiolog	0.70209697
64	MP0001727_abnormal_embryo_implantation	0.69953911
65	MP0008260_abnormal_autophagy	0.69661228
66	MP0000598_abnormal_liver_morphology	0.69406468
67	MP0004233_abnormal_muscle_weight	0.68142970
68	MP0003221_abnormal_cardiomyocyte_apopto	0.67068856
69	MP0003698_abnormal_male_reproductive	0.66087050
70	MP0003959_abnormal_lean_body	0.65246219
71	MP0001873_stomach_inflammation	0.65223706
72	MP0003303_peritoneal_inflammation	0.65131965
73	MP0000015_abnormal_ear_pigmentation	0.63240581
74	MP0003699_abnormal_female_reproductive	0.61215929
75	MP0005501_abnormal_skin_physiology	0.59855199
76	MP0005377_hearing/vestibular/ear_phenot	0.58361612
77	MP0003878_abnormal_ear_physiology	0.58361612
78	MP0009765_abnormal_xenobiotic_induced	0.58291177
79	MP0000653_abnormal_sex_gland	0.56025566
80	MP0005646_abnormal_pituitary_gland	0.55318587
81	MP0000343_altered_response_to	0.54691955
82	MP0001145_abnormal_male_reproductive	0.53896288
83	MP0004885_abnormal_endolymph	0.52697002
84	MP0005384_cellular_phenotype	0.52624283
85	MP0001764_abnormal_homeostasis	0.52521344
86	MP0008872_abnormal_physiological_respon	0.51288706
87	MP0002084_abnormal_developmental_patter	0.51139956
88	MP0001881_abnormal_mammary_gland	0.49383917
89	MP0002161_abnormal_fertility/fecundity	0.48605824
90	MP0002085_abnormal_embryonic_tissue	0.48173688
91	MP0000747_muscle_weakness	0.48054132
92	MP0003879_abnormal_hair_cell	0.46521809
93	MP0005621_abnormal_cell_physiology	0.46501519
94	MP0009703_decreased_birth_body	0.45592167
95	MP0005410_abnormal_fertilization	0.45034520
96	MP0001191_abnormal_skin_condition	0.41808136
97	MP0005647_abnormal_sex_gland	0.41264988
98	MP0001784_abnormal_fluid_regulation	0.41024785
99	MP0009763_increased_sensitivity_to	0.40563390
100	MP0005332_abnormal_amino_acid	0.40466148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Poikilocytosis (HP:0004447)	9.02109039
2	Reticulocytosis (HP:0001923)	8.65693274
3	Abnormal gallbladder physiology (HP:0012438)	7.02668794
4	Cholecystitis (HP:0001082)	7.02668794
5	Abnormal hemoglobin (HP:0011902)	6.66044755
6	Abnormality of reticulocytes (HP:0004312)	6.34566571
7	Polycythemia (HP:0001901)	5.66377468
8	Acanthocytosis (HP:0001927)	5.61199765
9	Cholelithiasis (HP:0001081)	5.51210977
10	Abnormal gallbladder morphology (HP:0012437)	4.96862084
11	Ileus (HP:0002595)	4.84303598
12	Hyperbilirubinemia (HP:0002904)	4.52482492
13	Paralysis (HP:0003470)	4.49814777
14	Truncus arteriosus (HP:0001660)	4.30041241
15	Hyperthyroidism (HP:0000836)	3.97479323
16	Abnormality of the gallbladder (HP:0005264)	3.84085550
17	Microcytic anemia (HP:0001935)	3.79186497
18	Pallor (HP:0000980)	3.70183804
19	Hypertensive crisis (HP:0100735)	3.70140877
20	Prolonged bleeding time (HP:0003010)	3.22989678
21	Diaphragmatic weakness (HP:0009113)	3.14713277
22	Birth length less than 3rd percentile (HP:0003561)	3.08499718
23	Abnormal large intestine physiology (HP:0012700)	2.96064594
24	Abnormal number of erythroid precursors (HP:0012131)	2.95328578
25	Hypochromic microcytic anemia (HP:0004840)	2.94590291
26	Bowel incontinence (HP:0002607)	2.92341442
27	Seborrheic dermatitis (HP:0001051)	2.90028370
28	Abnormality of homocysteine metabolism (HP:0010919)	2.89543759
29	Homocystinuria (HP:0002156)	2.89543759
30	Abnormality of cells of the erythroid lineage (HP:0012130)	2.74379771
31	Nonimmune hydrops fetalis (HP:0001790)	2.71461739
32	Insomnia (HP:0100785)	2.70595999
33	Hypoparathyroidism (HP:0000829)	2.69382063
34	Nausea (HP:0002018)	2.56397004
35	Chromsome breakage (HP:0040012)	2.50310791
36	Impaired platelet aggregation (HP:0003540)	2.43150398
37	Abnormal platelet function (HP:0011869)	2.43150398
38	Petechiae (HP:0000967)	2.41093969
39	Ankyloglossia (HP:0010296)	2.40965826
40	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.39182858
41	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.38915274
42	Acute myeloid leukemia (HP:0004808)	2.32422430
43	Short middle phalanx of the 5th finger (HP:0004220)	2.25871263
44	Abnormality of the tricuspid valve (HP:0001702)	2.22874431
45	Hepatocellular carcinoma (HP:0001402)	2.22202417
46	Upper limb muscle weakness (HP:0003484)	2.22025980
47	Abnormality of cochlea (HP:0000375)	2.19114682
48	Orthostatic hypotension (HP:0001278)	2.17596848
49	Cutaneous photosensitivity (HP:0000992)	2.09907823
50	Abnormality of iron homeostasis (HP:0011031)	2.09296996
51	Atelectasis (HP:0100750)	2.05501800
52	Abnormality of the fingertips (HP:0001211)	2.04620173
53	Gastrointestinal dysmotility (HP:0002579)	2.03634938
54	Abnormality of transition element cation homeostasis (HP:0011030)	2.03312497
55	Peripheral hypomyelination (HP:0007182)	2.00731613
56	Increased serum pyruvate (HP:0003542)	2.00522577
57	Abnormality of glycolysis (HP:0004366)	2.00346892
58	Abnormality of the heme biosynthetic pathway (HP:0010472)	11.8285616
59	Increased serum ferritin (HP:0003281)	1.99339495
60	Myelodysplasia (HP:0002863)	1.93052297
61	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.88819383
62	Duplicated collecting system (HP:0000081)	1.86921657
63	Hypochromic anemia (HP:0001931)	1.86699335
64	Tinnitus (HP:0000360)	1.86266366
65	Increased mean platelet volume (HP:0011877)	1.86061019
66	Ventricular fibrillation (HP:0001663)	1.79080900
67	Breech presentation (HP:0001623)	1.77204380
68	Neoplasm of head and neck (HP:0012288)	1.75816522
69	Esophageal neoplasm (HP:0100751)	1.75816522
70	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.71229280
71	Abnormality of nail color (HP:0100643)	1.71185349
72	Cortical dysplasia (HP:0002539)	1.70884436
73	Abnormal platelet volume (HP:0011876)	1.68713097
74	Epistaxis (HP:0000421)	1.66650825
75	Acute encephalopathy (HP:0006846)	1.63426806
76	Osteomalacia (HP:0002749)	1.61256572
77	Cerebral palsy (HP:0100021)	1.61182734
78	Long clavicles (HP:0000890)	1.57319323
79	Abnormality of oral frenula (HP:0000190)	1.56923477
80	Breast hypoplasia (HP:0003187)	1.56527257
81	Septate vagina (HP:0001153)	1.56503711
82	Hyponatremia (HP:0002902)	1.55838638
83	Abnormally folded helix (HP:0008544)	1.55249448
84	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.54737341
85	Abnormality of the renal collecting system (HP:0004742)	1.53898830
86	Morphological abnormality of the inner ear (HP:0011390)	1.53421570
87	Small intestinal stenosis (HP:0012848)	1.52736347
88	Duodenal stenosis (HP:0100867)	1.52736347
89	Autoamputation (HP:0001218)	1.52249663
90	Sandal gap (HP:0001852)	1.52103711
91	Overlapping toe (HP:0001845)	1.51538493
92	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.51183511
93	Onycholysis (HP:0001806)	1.50328835
94	Pancreatic islet-cell hyperplasia (HP:0004510)	1.47566402
95	Reticulocytopenia (HP:0001896)	1.46632421
96	Abnormality of the preputium (HP:0100587)	1.46148451
97	Aplastic anemia (HP:0001915)	1.41925199
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.41589102
99	Venous insufficiency (HP:0005293)	1.40884549
100	Obstructive lung disease (HP:0006536)	1.39824943

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	7.75595064
2	RIPK4	3.56992775
3	CLK1	3.46825204
4	PLK4	2.62836243
5	TTK	2.57953466
6	BMX	2.51750533
7	KSR2	2.47065019
8	PRPF4B	2.35039532
9	MST4	2.17232536
10	CDC7	2.09984914
11	STK4	2.04258611
12	SCYL2	1.97930763
13	BMPR2	1.90049626
14	CCNB1	1.89833038
15	RAF1	1.88869892
16	BRSK2	1.80631317
17	WEE1	1.74814581
18	TAOK2	1.61375485
19	MAP3K8	1.60743581
20	PIM1	1.58984828
21	EEF2K	1.55656031
22	MAP3K2	1.54852900
23	NTRK3	1.48729588
24	KSR1	1.46391246
25	CHEK2	1.38731431
26	DYRK3	1.38621458
27	NME1	1.38568113
28	BUB1	1.35193460
29	WNK1	1.26132394
30	TRPM7	1.23902670
31	RPS6KA5	1.23784781
32	PLK3	1.20092557
33	SRPK1	1.18996920
34	IRAK3	1.18661711
35	ICK	1.15142273
36	BRSK1	1.11538228
37	MAP2K3	1.10678607
38	TSSK6	1.05765515
39	ZAK	1.05455464
40	MAP2K1	1.04780747
41	PBK	1.00157996
42	CDK12	0.99300909
43	NEK1	0.99261040
44	STK3	0.95229951
45	NEK2	0.92925822
46	MARK3	0.92037735
47	JAK2	0.91127813
48	ATR	0.88213140
49	BRAF	0.88084172
50	PLK1	0.87680246
51	CHEK1	0.80469655
52	MATK	0.77455302
53	MAP3K10	0.77153762
54	MAP3K1	0.77113054
55	NME2	0.75705134
56	TEC	0.75007538
57	CAMK1D	0.74514151
58	RPS6KB2	0.73915626
59	ATM	0.72656299
60	ALK	0.64078427
61	BTK	0.62730685
62	CDK1	0.60787687
63	PDK2	0.59913929
64	EIF2AK3	0.59189060
65	CDK2	0.58731888
66	PAK1	0.54968082
67	RET	0.50217465
68	AURKB	0.49206273
69	MTOR	0.48165389
70	PLK2	0.47913222
71	SGK1	0.46242314
72	SYK	0.44938922
73	ILK	0.43195942
74	CDK4	0.42554786
75	CSNK2A2	0.42038477
76	AKT1	0.40206335
77	JAK3	0.39567265
78	MAPK11	0.39328546
79	CSNK2A1	0.37570510
80	MAPK12	0.36901578
81	PRKAA1	0.35450829
82	TLK1	0.34138696
83	MAP3K6	0.34015893
84	VRK1	0.33027553
85	AKT2	0.32822284
86	PRKACG	0.32692904
87	AURKA	0.32255091
88	STK16	0.32133181
89	PTK2B	0.31390580
90	MAPKAPK5	0.31220126
91	MAPK3	0.31122901
92	CDK7	0.30884095
93	MAP3K4	0.30691570
94	PRKAA2	0.30144951
95	MAP3K5	0.29700386
96	BRD4	0.28032692
97	MAPK14	0.27822768
98	GRK6	0.27522921
99	RPS6KA4	0.27004698
100	MAPKAPK3	0.26424410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.62749746
2	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	4.60408956
3	DNA replication_Homo sapiens_hsa03030	3.47473177
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.43517465
5	Mismatch repair_Homo sapiens_hsa03430	3.27745791
6	One carbon pool by folate_Homo sapiens_hsa00670	2.85583555
7	Homologous recombination_Homo sapiens_hsa03440	2.66736150
8	Cell cycle_Homo sapiens_hsa04110	2.55241363
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.21983995
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.18757773
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98806106
12	RNA transport_Homo sapiens_hsa03013	1.86618162
13	Spliceosome_Homo sapiens_hsa03040	1.84981409
14	Pyruvate metabolism_Homo sapiens_hsa00620	1.75766496
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.64429195
16	Base excision repair_Homo sapiens_hsa03410	1.59269298
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.53379589
18	Basal transcription factors_Homo sapiens_hsa03022	1.51259436
19	Ribosome_Homo sapiens_hsa03010	1.49328124
20	Acute myeloid leukemia_Homo sapiens_hsa05221	1.48855044
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.47096441
22	Carbon metabolism_Homo sapiens_hsa01200	1.43347562
23	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.41149935
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39749980
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33409180
26	Non-small cell lung cancer_Homo sapiens_hsa05223	1.22257006
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.22018337
28	Proteasome_Homo sapiens_hsa03050	1.21558301
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.20502027
30	RNA polymerase_Homo sapiens_hsa03020	1.18610190
31	Viral carcinogenesis_Homo sapiens_hsa05203	1.11580224
32	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.05003803
33	Malaria_Homo sapiens_hsa05144	1.03483732
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01980792
35	Thyroid cancer_Homo sapiens_hsa05216	1.00891415
36	Alcoholism_Homo sapiens_hsa05034	1.00834286
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.98784646
38	Pancreatic cancer_Homo sapiens_hsa05212	0.98558453
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98156091
40	Oocyte meiosis_Homo sapiens_hsa04114	0.95691615
41	Olfactory transduction_Homo sapiens_hsa04740	0.95037110
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94979128
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.92325725
44	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.91592440
45	Renal cell carcinoma_Homo sapiens_hsa05211	0.87769489
46	Parkinsons disease_Homo sapiens_hsa05012	0.87221764
47	Type II diabetes mellitus_Homo sapiens_hsa04930	0.83470834
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.82897642
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82879845
50	Pentose phosphate pathway_Homo sapiens_hsa00030	0.82537863
51	Huntingtons disease_Homo sapiens_hsa05016	0.79548165
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.79339125
53	mTOR signaling pathway_Homo sapiens_hsa04150	0.78762197
54	Purine metabolism_Homo sapiens_hsa00230	0.77734816
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76557055
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.72390569
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71930255
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.70859891
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.69826484
60	RNA degradation_Homo sapiens_hsa03018	0.69281706
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.69199582
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66896139
63	Bladder cancer_Homo sapiens_hsa05219	0.63979667
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63906309
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63280019
66	Glutathione metabolism_Homo sapiens_hsa00480	0.63023547
67	Hepatitis B_Homo sapiens_hsa05161	0.59146420
68	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.58405460
69	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.57795254
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56976106
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.56430510
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56370646
73	Apoptosis_Homo sapiens_hsa04210	0.55224480
74	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.54697508
75	Propanoate metabolism_Homo sapiens_hsa00640	0.53971092
76	p53 signaling pathway_Homo sapiens_hsa04115	0.52555709
77	VEGF signaling pathway_Homo sapiens_hsa04370	0.51899084
78	Glioma_Homo sapiens_hsa05214	0.48717384
79	Sulfur relay system_Homo sapiens_hsa04122	0.47885512
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46906136
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.46886236
82	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45351756
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.45290125
84	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.45044459
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44386642
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43257536
87	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.42337110
88	Metabolic pathways_Homo sapiens_hsa01100	0.41863904
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41639083
90	Fatty acid elongation_Homo sapiens_hsa00062	0.41305472
91	AMPK signaling pathway_Homo sapiens_hsa04152	0.40959892
92	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38908213
93	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.38870045
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37513084
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.36882520
96	ABC transporters_Homo sapiens_hsa02010	0.36102221
97	Prostate cancer_Homo sapiens_hsa05215	0.35518370
98	Endometrial cancer_Homo sapiens_hsa05213	0.33432720
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32626482
100	Platelet activation_Homo sapiens_hsa04611	0.30919100

HBBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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