HBD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.88822616
2heme biosynthetic process (GO:0006783)9.50376333
3erythrocyte maturation (GO:0043249)9.41951617
4erythrocyte development (GO:0048821)8.99324465
5heme metabolic process (GO:0042168)8.16123819
6response to methylmercury (GO:0051597)6.73142729
7regulation of response to osmotic stress (GO:0047484)6.58822429
8myeloid cell development (GO:0061515)6.47208726
9antibacterial humoral response (GO:0019731)6.23793705
10tetrapyrrole metabolic process (GO:0033013)6.15409879
11innate immune response in mucosa (GO:0002227)6.02706312
12disruption of cells of other organism (GO:0044364)5.97984033
13killing of cells of other organism (GO:0031640)5.97984033
14antimicrobial humoral response (GO:0019730)5.73537697
15defense response to fungus (GO:0050832)5.68640763
16hydrogen peroxide catabolic process (GO:0042744)5.17803172
17glycine transport (GO:0015816)5.10823457
18mucosal immune response (GO:0002385)4.87647689
19one-carbon compound transport (GO:0019755)4.83001141
20response to insecticide (GO:0017085)4.72788681
21response to lead ion (GO:0010288)4.67955871
22organ or tissue specific immune response (GO:0002251)4.54521248
23response to arsenic-containing substance (GO:0046685)4.37332708
24negative regulation of erythrocyte differentiation (GO:0045647)4.21874483
25erythrocyte differentiation (GO:0030218)4.17704672
26bicarbonate transport (GO:0015701)4.14070907
27granulocyte differentiation (GO:0030851)4.07947244
28positive regulation of granulocyte differentiation (GO:0030854)4.02415404
29actin filament capping (GO:0051693)4.02290962
30negative regulation of viral entry into host cell (GO:0046597)3.98817827
31response to fungus (GO:0009620)3.95324400
32definitive hemopoiesis (GO:0060216)3.93957147
33megakaryocyte development (GO:0035855)3.93407445
34pigment biosynthetic process (GO:0046148)3.74624777
353-UTR-mediated mRNA stabilization (GO:0070935)3.69548006
36positive regulation of fibroblast migration (GO:0010763)3.69038858
37intracellular estrogen receptor signaling pathway (GO:0030520)3.68162352
38regulation of platelet aggregation (GO:0090330)3.64736146
39very-low-density lipoprotein particle assembly (GO:0034379)3.60118079
40regulation of erythrocyte differentiation (GO:0045646)3.49668172
41cellular response to arsenic-containing substance (GO:0071243)3.49585006
42killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.48173483
43disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.48173483
44iron ion import (GO:0097286)3.42293072
45platelet formation (GO:0030220)3.42126970
46pigment metabolic process (GO:0042440)3.41244639
47hydrogen peroxide metabolic process (GO:0042743)3.39111983
48embryonic hemopoiesis (GO:0035162)3.38318053
49positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.34524722
50regulation of RNA export from nucleus (GO:0046831)3.33440536
51positive regulation of erythrocyte differentiation (GO:0045648)3.30099339
52protein targeting to plasma membrane (GO:0072661)3.26628760
53modulation by virus of host process (GO:0019054)3.24163682
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19115862
55cellular response to virus (GO:0098586)3.15545104
56detection of bacterium (GO:0016045)3.15134509
57cell killing (GO:0001906)3.14513267
58negative regulation of actin filament depolymerization (GO:0030835)3.13556643
59protein-cofactor linkage (GO:0018065)3.11902581
60regulation of viral entry into host cell (GO:0046596)3.10337167
61response to peptidoglycan (GO:0032494)3.06757547
62granulocyte activation (GO:0036230)3.02737721
63positive regulation of megakaryocyte differentiation (GO:0045654)2.97514395
64detection of other organism (GO:0098543)2.96340716
65neutrophil activation involved in immune response (GO:0002283)2.95638029
66neutrophil activation (GO:0042119)2.87184508
67negative regulation of execution phase of apoptosis (GO:1900118)2.82690202
68hepatocyte apoptotic process (GO:0097284)2.81584443
69regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.81545941
70cellular response to dexamethasone stimulus (GO:0071549)2.78166513
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77521623
72N-terminal protein amino acid acetylation (GO:0006474)2.76539051
73hemopoiesis (GO:0030097)2.76043826
74defense response to Gram-positive bacterium (GO:0050830)2.74703270
75regulation of nucleobase-containing compound transport (GO:0032239)2.74242929
76regulation of granulocyte differentiation (GO:0030852)2.67913791
77modulation by symbiont of host cellular process (GO:0044068)2.67521232
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67012379
79positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.66477168
80superoxide anion generation (GO:0042554)2.62100029
81iron ion homeostasis (GO:0055072)2.61128281
82purine-containing compound salvage (GO:0043101)2.56367552
83mitochondrion degradation (GO:0000422)2.55556637
84response to dexamethasone (GO:0071548)2.54712561
85DNA topological change (GO:0006265)2.53040033
86imidazole-containing compound metabolic process (GO:0052803)2.48690769
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46463267
88cofactor biosynthetic process (GO:0051188)2.42336588
89negative regulation of actin filament polymerization (GO:0030837)2.41480806
90regulation of mast cell degranulation (GO:0043304)2.38288187
91calcium-mediated signaling using intracellular calcium source (GO:0035584)2.36309127
92negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.34911306
93regulation of growth of symbiont in host (GO:0044126)2.34911306
94protoporphyrinogen IX metabolic process (GO:0046501)16.1362771
95protoporphyrinogen IX biosynthetic process (GO:0006782)13.2012447
96hemoglobin metabolic process (GO:0020027)12.4708602
97porphyrin-containing compound biosynthetic process (GO:0006779)11.7006719
98* oxygen transport (GO:0015671)11.5744963
99* gas transport (GO:0015669)10.6115961
100tetrapyrrole biosynthetic process (GO:0033014)10.3842987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.22079901
2GATA1_19941826_ChIP-Seq_K562_Human6.35682069
3E2F7_22180533_ChIP-Seq_HELA_Human4.98711027
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.61890127
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.53920402
6SCL_19346495_ChIP-Seq_HPC-7_Human4.21657164
7FOXM1_23109430_ChIP-Seq_U2OS_Human4.17276696
8* GATA2_19941826_ChIP-Seq_K562_Human3.74032200
9TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.45182550
10GATA1_19941827_ChIP-Seq_MEL_Mouse3.43250041
11KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.30593185
12GATA1_22383799_ChIP-Seq_G1ME_Mouse2.52124078
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45718498
14VDR_21846776_ChIP-Seq_THP-1_Human2.31167030
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20648600
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10904835
17* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06134226
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96992830
19MYC_22102868_ChIP-Seq_BL_Human1.93491664
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88676137
21TCF7_22412390_ChIP-Seq_EML_Mouse1.86671489
22NCOR1_26117541_ChIP-Seq_K562_Human1.83515102
23VDR_24763502_ChIP-Seq_THP-1_Human1.75249813
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75125449
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69510270
26GATA2_22383799_ChIP-Seq_G1ME_Mouse1.67394452
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66867692
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65117510
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59214355
30MAF_26560356_Chip-Seq_TH1_Human1.55756697
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54780044
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.54388114
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53522853
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53324129
35UTX_26944678_Chip-Seq_JUKART_Human1.48628601
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47920274
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47314605
38TFEB_21752829_ChIP-Seq_HELA_Human1.37192288
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36015462
40KDM2B_26808549_Chip-Seq_DND41_Human1.34732794
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33876276
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.31777499
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30377229
44SPI1_23547873_ChIP-Seq_NB4_Human1.27806485
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26204042
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.24552561
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23520373
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21157624
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20416843
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.19334066
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18018364
52SPI1_23127762_ChIP-Seq_K562_Human1.16490899
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14032635
54MYB_26560356_Chip-Seq_TH1_Human1.12887980
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12851801
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09421357
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09232603
58MYB_26560356_Chip-Seq_TH2_Human1.05343895
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04961857
60BCOR_27268052_Chip-Seq_Bcells_Human1.04860490
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02491195
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01814560
63MAF_26560356_Chip-Seq_TH2_Human1.01268609
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99446138
65CIITA_25753668_ChIP-Seq_RAJI_Human0.98630385
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98001675
67BCL6_27268052_Chip-Seq_Bcells_Human0.97681509
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96805898
69CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96477937
70ZNF263_19887448_ChIP-Seq_K562_Human0.95245870
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95221662
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94782671
73IRF8_27001747_Chip-Seq_BMDM_Mouse0.94263457
74E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94196043
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93657926
76STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92010836
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91677794
78FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89920354
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.89854162
80ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88497827
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87279264
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85352515
83P68_20966046_ChIP-Seq_HELA_Human0.85064643
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84271116
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82650013
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82054191
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81837417
88CTCF_21964334_Chip-Seq_Bcells_Human0.81786760
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81402164
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81270072
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80577424
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79100707
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.79023758
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.78896947
95PU_27001747_Chip-Seq_BMDM_Mouse0.78878147
96LXR_22292898_ChIP-Seq_THP-1_Human0.78594237
97KDM2B_26808549_Chip-Seq_K562_Human0.77770497
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77005795
99SPI1_20517297_ChIP-Seq_HL60_Human0.77001262
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76050736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.16102975
2MP0005397_hematopoietic_system_phenotyp3.44763444
3MP0001545_abnormal_hematopoietic_system3.44763444
4MP0003303_peritoneal_inflammation2.94930175
5MP0009278_abnormal_bone_marrow2.25253728
6MP0005464_abnormal_platelet_physiology2.08198563
7MP0004147_increased_porphyrin_level10.9311940
8MP0003656_abnormal_erythrocyte_physiolo10.1774213
9MP0008260_abnormal_autophagy1.95100144
10MP0005636_abnormal_mineral_homeostasis1.73768921
11MP0003186_abnormal_redox_activity1.70979929
12MP0004808_abnormal_hematopoietic_stem1.62936628
13MP0003111_abnormal_nucleus_morphology1.59333687
14MP0003878_abnormal_ear_physiology1.43535330
15MP0005377_hearing/vestibular/ear_phenot1.43535330
16MP0002398_abnormal_bone_marrow1.41905047
17MP0003045_fibrosis1.40675116
18MP0000685_abnormal_immune_system1.40111622
19MP0008995_early_reproductive_senescence1.38228068
20MP0003172_abnormal_lysosome_physiology1.36787732
21MP0001529_abnormal_vocalization1.34514732
22MP0002822_catalepsy1.31965316
23MP0003191_abnormal_cellular_cholesterol1.31220473
24MP0002722_abnormal_immune_system1.30844815
25MP0000689_abnormal_spleen_morphology1.26461868
26MP0005025_abnormal_response_to1.16460295
27MP0009765_abnormal_xenobiotic_induced1.12813292
28MP0009785_altered_susceptibility_to1.12388471
29MP0002396_abnormal_hematopoietic_system1.11636991
30MP0000749_muscle_degeneration1.11291563
31MP0009931_abnormal_skin_appearance1.05942843
32MP0002429_abnormal_blood_cell1.05848547
33MP0000465_gastrointestinal_hemorrhage1.04702506
34MP0005076_abnormal_cell_differentiation1.04411596
35MP0009764_decreased_sensitivity_to1.03045799
36MP0003436_decreased_susceptibility_to1.00565506
37MP0002132_abnormal_respiratory_system1.00523595
38MP0006036_abnormal_mitochondrial_physio0.96528302
39MP0005451_abnormal_body_composition0.95147318
40MP0009333_abnormal_splenocyte_physiolog0.94816982
41MP0002095_abnormal_skin_pigmentation0.94197502
42MP0002166_altered_tumor_susceptibility0.91923344
43MP0010307_abnormal_tumor_latency0.91799283
44MP0002419_abnormal_innate_immunity0.91514759
45MP0002405_respiratory_system_inflammati0.91265661
46MP0005075_abnormal_melanosome_morpholog0.87910747
47MP0008775_abnormal_heart_ventricle0.85230289
48MP0000015_abnormal_ear_pigmentation0.84851789
49MP0003566_abnormal_cell_adhesion0.82233277
50MP0000703_abnormal_thymus_morphology0.81002553
51MP0009763_increased_sensitivity_to0.77139005
52MP0000716_abnormal_immune_system0.73060771
53MP0003879_abnormal_hair_cell0.72312962
54MP0002420_abnormal_adaptive_immunity0.72244707
55MP0004185_abnormal_adipocyte_glucose0.72045261
56MP0000313_abnormal_cell_death0.70966641
57MP0005000_abnormal_immune_tolerance0.70722891
58MP0002653_abnormal_ependyma_morphology0.70526819
59MP0001819_abnormal_immune_cell0.70308598
60MP0003221_abnormal_cardiomyocyte_apopto0.66716079
61MP0000609_abnormal_liver_physiology0.65642365
62MP0003763_abnormal_thymus_physiology0.65084022
63MP0003077_abnormal_cell_cycle0.64542099
64MP0002019_abnormal_tumor_incidence0.62890145
65MP0008874_decreased_physiological_sensi0.62755689
66MP0008057_abnormal_DNA_replication0.60455608
67MP0008872_abnormal_physiological_respon0.60112191
68MP0002332_abnormal_exercise_endurance0.58087492
69MP0005501_abnormal_skin_physiology0.58049358
70MP0000598_abnormal_liver_morphology0.57384977
71MP0005621_abnormal_cell_physiology0.57211206
72MP0009643_abnormal_urine_homeostasis0.56282110
73MP0008058_abnormal_DNA_repair0.54960338
74MP0002009_preneoplasia0.54663629
75MP0000343_altered_response_to0.52665247
76MP0003786_premature_aging0.50948565
77MP0004947_skin_inflammation0.50555447
78MP0001915_intracranial_hemorrhage0.49940965
79MP0001790_abnormal_immune_system0.48993855
80MP0005387_immune_system_phenotype0.48993855
81MP0005058_abnormal_lysosome_morphology0.48980621
82MP0005319_abnormal_enzyme/_coenzyme0.48121159
83MP0003795_abnormal_bone_structure0.47662513
84MP0002080_prenatal_lethality0.46658392
85MP0001756_abnormal_urination0.45768783
86MP0001845_abnormal_inflammatory_respons0.45692033
87MP0004130_abnormal_muscle_cell0.45144820
88MP0009697_abnormal_copulation0.45061297
89MP0002006_tumorigenesis0.44193222
90MP0003453_abnormal_keratinocyte_physiol0.43794015
91MP0003724_increased_susceptibility_to0.43673769
92MP0005384_cellular_phenotype0.42387303
93MP0008770_decreased_survivor_rate0.42334677
94MP0000747_muscle_weakness0.42286546
95MP0001663_abnormal_digestive_system0.41805442
96MP0004957_abnormal_blastocyst_morpholog0.40846352
97MP0002452_abnormal_antigen_presenting0.40463326
98MP0002083_premature_death0.40060743
99MP0001730_embryonic_growth_arrest0.39173122
100MP0002136_abnormal_kidney_physiology0.38929813

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic anemia (HP:0001931)7.27828585
2Reticulocytosis (HP:0001923)7.15479992
3Abnormal hemoglobin (HP:0011902)6.83277434
4Cholelithiasis (HP:0001081)6.62636086
5Paralysis (HP:0003470)6.41661846
6* Microcytic anemia (HP:0001935)6.41640617
7Abnormal gallbladder morphology (HP:0012437)5.99723354
8Polycythemia (HP:0001901)5.86110858
9Acanthocytosis (HP:0001927)5.46907045
10Diaphragmatic weakness (HP:0009113)4.82613098
11Abnormality of reticulocytes (HP:0004312)4.70000815
12Toxemia of pregnancy (HP:0100603)4.59388352
13Ileus (HP:0002595)4.47595261
14Hyperbilirubinemia (HP:0002904)4.31170072
15Abnormality of the gallbladder (HP:0005264)4.30743789
16Abnormality of iron homeostasis (HP:0011031)3.87665123
17Prolonged bleeding time (HP:0003010)3.72184496
18Cholecystitis (HP:0001082)3.56131296
19Abnormal gallbladder physiology (HP:0012438)3.56131296
20Abnormality of transition element cation homeostasis (HP:0011030)3.41773813
21Pallor (HP:0000980)2.90795565
22Petechiae (HP:0000967)2.85610424
23Autoamputation (HP:0001218)2.81372531
24Nausea (HP:0002018)2.79996740
25Abnormality of the fingertips (HP:0001211)2.72274604
26Insomnia (HP:0100785)2.70975431
27Cutaneous photosensitivity (HP:0000992)2.69037019
28Hypertensive crisis (HP:0100735)2.65013414
29Hepatocellular carcinoma (HP:0001402)2.51189376
30Epistaxis (HP:0000421)2.49309124
31Osteomalacia (HP:0002749)2.47213354
32Increased serum ferritin (HP:0003281)2.43803109
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40829622
34Cerebral palsy (HP:0100021)2.40143384
35Osteomyelitis (HP:0002754)2.38721983
36Abnormal number of erythroid precursors (HP:0012131)2.37785022
37Abnormality of sodium homeostasis (HP:0010931)2.36770602
38Abnormal platelet volume (HP:0011876)2.35421420
39Gastrointestinal infarctions (HP:0005244)2.31185377
40Increased mean platelet volume (HP:0011877)2.26283640
41Autoimmune thrombocytopenia (HP:0001973)2.22882186
42Abnormal platelet function (HP:0011869)2.10169468
43Impaired platelet aggregation (HP:0003540)2.10169468
44Hypoparathyroidism (HP:0000829)2.10132259
45Abnormality of cells of the erythroid lineage (HP:0012130)2.06314753
46Hyponatremia (HP:0002902)2.03420837
47Visual hallucinations (HP:0002367)2.01200405
48* Abnormality of the heme biosynthetic pathway (HP:0010472)14.3650064
49Hypochromic microcytic anemia (HP:0004840)12.6451769
50Poikilocytosis (HP:0004447)11.5308664
51Paresthesia (HP:0003401)1.99468774
52Pustule (HP:0200039)1.98419897
53Gastrointestinal dysmotility (HP:0002579)1.97608976
54Urticaria (HP:0001025)1.96956214
55Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95871006
56Recurrent abscess formation (HP:0002722)1.90172514
57Diplopia (HP:0000651)1.79296308
58Abnormality of binocular vision (HP:0011514)1.79296308
59Anhidrosis (HP:0000970)1.78710038
60Thrombophlebitis (HP:0004418)1.77205564
61Neoplasm of the liver (HP:0002896)1.75086579
62Obstructive lung disease (HP:0006536)1.72677255
63Chronic obstructive pulmonary disease (HP:0006510)1.72677255
64Autoimmune hemolytic anemia (HP:0001890)1.67760554
65Gingival bleeding (HP:0000225)1.67086255
66Cellulitis (HP:0100658)1.66779435
67Slow saccadic eye movements (HP:0000514)1.66611095
68Recurrent bacterial skin infections (HP:0005406)1.57971707
69Skin rash (HP:0000988)1.52837323
70Eczematoid dermatitis (HP:0000976)1.52762188
71Osteolytic defects of the hand bones (HP:0009699)1.52268480
72Osteolytic defects of the phalanges of the hand (HP:0009771)1.52268480
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.51057047
74Muscle fiber splitting (HP:0003555)1.49206782
75Prenatal maternal abnormality (HP:0002686)1.49195596
76Menorrhagia (HP:0000132)1.49158705
77Renal tubular acidosis (HP:0001947)1.48563332
78Orthostatic hypotension (HP:0001278)1.48310062
79Hypertriglyceridemia (HP:0002155)1.46726881
80Splenomegaly (HP:0001744)1.45401512
81Rectal prolapse (HP:0002035)1.43079671
82Anorexia (HP:0002039)1.40301708
83Purpura (HP:0000979)1.39739180
84Abnormality of renal resorption (HP:0011038)1.37874813
85Long clavicles (HP:0000890)1.37199272
86Bruising susceptibility (HP:0000978)1.35179634
87Abnormality of nail color (HP:0100643)1.33490357
88Hepatosplenomegaly (HP:0001433)1.31939960
89Spontaneous hematomas (HP:0007420)1.30287138
90Albinism (HP:0001022)1.29286722
91Gingivitis (HP:0000230)1.28931451
92Fatigue (HP:0012378)1.27275100
93Abnormality of macrophages (HP:0004311)1.27240308
94Erythema (HP:0010783)1.26173479
95Bone marrow hypocellularity (HP:0005528)1.25845967
96Distal lower limb amyotrophy (HP:0008944)1.24397050
97Recurrent viral infections (HP:0004429)1.23816785
98Nasal polyposis (HP:0100582)1.22924547
99Peripheral hypomyelination (HP:0007182)1.22765825
100Leukocytosis (HP:0001974)1.22251781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK18.03469688
2PRPF4B4.79213990
3MAP2K34.00814339
4TAOK23.60774004
5TAOK13.45966119
6MAP3K113.05891656
7GRK63.00803437
8MAP3K32.44067492
9WNK12.40818904
10BMX2.22486153
11PIM12.16794196
12DYRK32.11172050
13CAMK1D1.83953501
14RIPK41.83315341
15STK41.49113725
16CLK11.46327841
17MARK31.36922323
18SYK1.34150418
19MAP3K101.31900680
20PTK2B1.27546364
21MAP3K51.22546248
22RPS6KA51.20079045
23TNK21.17227106
24CDK121.14818393
25MAP3K11.13618826
26FGR1.07693859
27ERN11.05469530
28TESK21.01264011
29HIPK21.00719156
30CAMK1G0.96591381
31SCYL20.96492810
32TRPM70.93817623
33GRK50.92343627
34IKBKE0.92274174
35ZAP700.88801716
36PLK30.86946256
37RPS6KC10.85413904
38RPS6KL10.85413904
39SGK30.78698059
40BRSK10.78629634
41TEC0.77695778
42MAP3K60.75111958
43LYN0.74633040
44MAP2K10.73647838
45CDK40.72091469
46RPS6KA60.72004974
47IKBKB0.70836233
48SGK20.70815743
49DYRK1B0.68844845
50BTK0.67550166
51STK110.66909067
52FES0.66618875
53SIK30.64625190
54JAK20.63620103
55MAP4K10.63194618
56YES10.62539338
57MAP2K40.61811666
58IRAK40.61592814
59DYRK1A0.59432746
60KSR10.54875271
61TBK10.54138347
62MAP3K80.53635543
63MAPK110.53080592
64SGK10.50685014
65PLK10.49825712
66CDK60.48032044
67PRKAA20.47701190
68NEK20.45553099
69SMG10.42921168
70CAMK40.42818257
71PLK40.39881047
72RPS6KA20.38807813
73AKT10.38779776
74BRSK20.38755124
75HCK0.38078305
76MAP2K20.38056936
77BRAF0.38050725
78ICK0.34933690
79PBK0.33816530
80AKT20.33073439
81TRIB30.32615169
82CHUK0.31758932
83MAPKAPK20.31647342
84SGK2230.31388783
85SGK4940.31388783
86PRKACG0.31263595
87MAPK40.30747581
88SIK20.29258302
89PLK20.28968158
90ABL20.28929941
91MAPK30.28553503
92DYRK20.27676717
93MAPK120.26867045
94KDR0.24106944
95PINK10.24103991
96MTOR0.24033332
97BRD40.23293685
98CHEK10.22696367
99BLK0.22483884
100MARK20.21487965

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008606.62294234
2Malaria_Homo sapiens_hsa051445.11681921
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.32734776
4African trypanosomiasis_Homo sapiens_hsa051433.46513521
5Regulation of autophagy_Homo sapiens_hsa041402.62131281
6Collecting duct acid secretion_Homo sapiens_hsa049662.51691946
7Nitrogen metabolism_Homo sapiens_hsa009102.31697432
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02608350
9Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.94281580
10Non-small cell lung cancer_Homo sapiens_hsa052231.92640675
11Hematopoietic cell lineage_Homo sapiens_hsa046401.82524802
12Pancreatic cancer_Homo sapiens_hsa052121.73848812
13Chronic myeloid leukemia_Homo sapiens_hsa052201.67346755
14Cell cycle_Homo sapiens_hsa041101.63229788
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52763790
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52236993
17Asthma_Homo sapiens_hsa053101.49320716
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46826418
19Acute myeloid leukemia_Homo sapiens_hsa052211.40746949
20FoxO signaling pathway_Homo sapiens_hsa040681.25765980
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23447959
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23148181
23Bladder cancer_Homo sapiens_hsa052191.22128887
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.19977591
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.15622462
26Apoptosis_Homo sapiens_hsa042101.07468922
27Herpes simplex infection_Homo sapiens_hsa051681.05789908
28Hepatitis B_Homo sapiens_hsa051611.04942208
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.04628387
30Osteoclast differentiation_Homo sapiens_hsa043801.02304326
31Pentose phosphate pathway_Homo sapiens_hsa000301.02048464
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01383844
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.01338422
34ABC transporters_Homo sapiens_hsa020101.00696327
35HIF-1 signaling pathway_Homo sapiens_hsa040660.97836887
36Renal cell carcinoma_Homo sapiens_hsa052110.96822992
37Platelet activation_Homo sapiens_hsa046110.94726060
38Hepatitis C_Homo sapiens_hsa051600.90188258
39Small cell lung cancer_Homo sapiens_hsa052220.89812274
40B cell receptor signaling pathway_Homo sapiens_hsa046620.89712119
41AMPK signaling pathway_Homo sapiens_hsa041520.84516774
42Inositol phosphate metabolism_Homo sapiens_hsa005620.83697058
43Tuberculosis_Homo sapiens_hsa051520.83584364
44DNA replication_Homo sapiens_hsa030300.81570423
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80913785
46mTOR signaling pathway_Homo sapiens_hsa041500.77229311
47Measles_Homo sapiens_hsa051620.74269812
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71202237
49Fructose and mannose metabolism_Homo sapiens_hsa000510.70570041
50Influenza A_Homo sapiens_hsa051640.69205022
51Notch signaling pathway_Homo sapiens_hsa043300.68802259
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68472111
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68098717
54Prostate cancer_Homo sapiens_hsa052150.67354427
55Glioma_Homo sapiens_hsa052140.67146165
56Leishmaniasis_Homo sapiens_hsa051400.66570340
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65815927
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.65486584
59Phagosome_Homo sapiens_hsa041450.64573606
60Base excision repair_Homo sapiens_hsa034100.63990438
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63482663
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62469486
63Endometrial cancer_Homo sapiens_hsa052130.61689374
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60164032
65Viral carcinogenesis_Homo sapiens_hsa052030.59521714
66Epstein-Barr virus infection_Homo sapiens_hsa051690.59018509
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58019308
68p53 signaling pathway_Homo sapiens_hsa041150.55953688
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.55639029
70HTLV-I infection_Homo sapiens_hsa051660.54521766
71Nucleotide excision repair_Homo sapiens_hsa034200.52985678
72TNF signaling pathway_Homo sapiens_hsa046680.50927009
73Synaptic vesicle cycle_Homo sapiens_hsa047210.50312596
74Chemokine signaling pathway_Homo sapiens_hsa040620.47950448
75Type II diabetes mellitus_Homo sapiens_hsa049300.46644327
76Toxoplasmosis_Homo sapiens_hsa051450.43448021
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.43259509
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41340612
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40628312
80MicroRNAs in cancer_Homo sapiens_hsa052060.40574477
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38734108
82Melanoma_Homo sapiens_hsa052180.38014964
83Thyroid cancer_Homo sapiens_hsa052160.37660541
84Choline metabolism in cancer_Homo sapiens_hsa052310.36906244
85Lysosome_Homo sapiens_hsa041420.36851191
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35241942
87Prolactin signaling pathway_Homo sapiens_hsa049170.34440871
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34199185
89Shigellosis_Homo sapiens_hsa051310.32040783
90Endocytosis_Homo sapiens_hsa041440.31716913
91Oocyte meiosis_Homo sapiens_hsa041140.31442500
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31436656
93VEGF signaling pathway_Homo sapiens_hsa043700.31194919
94T cell receptor signaling pathway_Homo sapiens_hsa046600.31050938
95Fatty acid biosynthesis_Homo sapiens_hsa000610.29943726
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28582360
97Other glycan degradation_Homo sapiens_hsa005110.27880064
98Staphylococcus aureus infection_Homo sapiens_hsa051500.27317178
99N-Glycan biosynthesis_Homo sapiens_hsa005100.25943512
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.25559572

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