HBM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.90683567
2* oxygen transport (GO:0015671)9.11933581
3hemoglobin metabolic process (GO:0020027)8.58462915
4protoporphyrinogen IX biosynthetic process (GO:0006782)8.55000630
5* gas transport (GO:0015669)7.86924742
6porphyrin-containing compound biosynthetic process (GO:0006779)7.11923644
7erythrocyte maturation (GO:0043249)6.29951427
8tetrapyrrole biosynthetic process (GO:0033014)6.24668458
9defense response to fungus (GO:0050832)6.17148676
10heme biosynthetic process (GO:0006783)6.09996134
11detection of bacterium (GO:0016045)5.96909148
12erythrocyte development (GO:0048821)5.85328261
13porphyrin-containing compound metabolic process (GO:0006778)5.81585367
14killing of cells of other organism (GO:0031640)5.80259141
15disruption of cells of other organism (GO:0044364)5.80259141
16detection of other organism (GO:0098543)5.75789530
17antibacterial humoral response (GO:0019731)5.62943074
18innate immune response in mucosa (GO:0002227)5.62513794
19antimicrobial humoral response (GO:0019730)5.33380962
20neutrophil activation involved in immune response (GO:0002283)5.16305285
21heme metabolic process (GO:0042168)5.02156769
22mucosal immune response (GO:0002385)4.91953907
23leukocyte migration involved in inflammatory response (GO:0002523)4.76682820
24myeloid cell development (GO:0061515)4.76499576
25organ or tissue specific immune response (GO:0002251)4.75586917
26response to fungus (GO:0009620)4.73989186
27response to peptidoglycan (GO:0032494)4.72027040
28neutrophil activation (GO:0042119)4.51239670
29leukocyte aggregation (GO:0070486)4.48097164
30response to methylmercury (GO:0051597)4.34470404
31granulocyte activation (GO:0036230)4.21524154
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19566306
33negative regulation of cell killing (GO:0031342)4.19566306
34negative regulation of erythrocyte differentiation (GO:0045647)4.15879128
35disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.07905166
36killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.07905166
37regulation of response to osmotic stress (GO:0047484)4.07339195
38detection of external biotic stimulus (GO:0098581)4.03710000
39cellular extravasation (GO:0045123)3.92731929
40positive regulation of gamma-delta T cell activation (GO:0046645)3.79301396
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78999910
42intracellular estrogen receptor signaling pathway (GO:0030520)3.78862098
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72836611
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72836611
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.72836611
46modulation by symbiont of host immune response (GO:0052553)3.72836611
47positive regulation by symbiont of host defense response (GO:0052509)3.72836611
48modulation by symbiont of host defense response (GO:0052031)3.72836611
493-UTR-mediated mRNA stabilization (GO:0070935)3.71879357
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.70703020
51respiratory burst (GO:0045730)3.69344112
52hydrogen peroxide catabolic process (GO:0042744)3.66509342
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63977086
54positive regulation of granulocyte differentiation (GO:0030854)3.58209413
55defense response to Gram-positive bacterium (GO:0050830)3.56411547
56megakaryocyte development (GO:0035855)3.54679631
57regulation of mast cell degranulation (GO:0043304)3.54248486
58superoxide anion generation (GO:0042554)3.54063921
59tetrapyrrole metabolic process (GO:0033013)3.53158817
60antigen processing and presentation of endogenous antigen (GO:0019883)3.50459268
61negative regulation of viral entry into host cell (GO:0046597)3.48566031
62neutrophil mediated immunity (GO:0002446)3.47247615
63detection of biotic stimulus (GO:0009595)3.43233047
64positive regulation of fibroblast migration (GO:0010763)3.39652739
65negative regulation of phagocytosis (GO:0050765)3.36512085
66regulation of platelet aggregation (GO:0090330)3.32842931
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27340491
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26851452
69granulocyte differentiation (GO:0030851)3.26059501
70cell killing (GO:0001906)3.24423322
71regulation of mast cell activation involved in immune response (GO:0033006)3.24268346
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18470953
73modulation by virus of host process (GO:0019054)3.17249390
74regulation of B cell receptor signaling pathway (GO:0050855)3.15971409
75response to host immune response (GO:0052572)3.13660923
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13660923
77regulation of leukocyte degranulation (GO:0043300)3.11746647
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.10684406
79negative regulation of interleukin-6 production (GO:0032715)3.00862199
80regulation of natural killer cell differentiation (GO:0032823)2.99734676
81leukocyte degranulation (GO:0043299)2.99732365
82macrophage activation involved in immune response (GO:0002281)2.98858489
83glycine transport (GO:0015816)2.95687982
84cellular response to virus (GO:0098586)2.92080971
85negative regulation of interleukin-8 production (GO:0032717)2.91654414
86regulation of viral entry into host cell (GO:0046596)2.91366222
87microglial cell activation (GO:0001774)2.89629578
88negative regulation of interleukin-12 production (GO:0032695)2.89503830
89regulation of erythrocyte differentiation (GO:0045646)2.84509894
90erythrocyte differentiation (GO:0030218)2.83022033
91platelet formation (GO:0030220)2.82279126
92regulation of granulocyte differentiation (GO:0030852)2.81420801
93myeloid leukocyte mediated immunity (GO:0002444)2.81281856
94negative regulation of leukocyte mediated immunity (GO:0002704)2.80140864
95response to host (GO:0075136)2.79930267
96response to host defenses (GO:0052200)2.79930267
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79930267
98regulation of growth of symbiont in host (GO:0044126)2.79487205
99negative regulation of growth of symbiont in host (GO:0044130)2.79487205
100negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.79487205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.79884243
2GATA1_19941826_ChIP-Seq_K562_Human4.50150321
3SCL_19346495_ChIP-Seq_HPC-7_Human3.64459681
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38068373
5VDR_21846776_ChIP-Seq_THP-1_Human3.36987407
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.00855935
7GATA1_19941827_ChIP-Seq_MEL_Mouse2.90289938
8TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.83841903
9GATA2_19941826_ChIP-Seq_K562_Human2.80312704
10VDR_24763502_ChIP-Seq_THP-1_Human2.78810377
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55704189
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55138755
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52634854
14MYC_22102868_ChIP-Seq_BL_Human2.47653005
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46170349
16TCF7_22412390_ChIP-Seq_EML_Mouse2.33558672
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30338282
18SPI1_23547873_ChIP-Seq_NB4_Human2.30294489
19MAF_26560356_Chip-Seq_TH1_Human2.29474253
20RUNX1_22412390_ChIP-Seq_EML_Mouse2.28954830
21SPI1_23127762_ChIP-Seq_K562_Human2.21420294
22KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.21344092
23UTX_26944678_Chip-Seq_JUKART_Human2.21095647
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.19336798
25GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19253682
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.06871608
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04830967
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04696712
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03617167
30KDM2B_26808549_Chip-Seq_DND41_Human1.99330422
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97238169
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96837068
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.96602869
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90877289
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88604840
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86687489
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86514765
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81784696
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78870913
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.76018115
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74502041
42MYB_26560356_Chip-Seq_TH2_Human1.72689118
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.71640166
44GATA2_22383799_ChIP-Seq_G1ME_Mouse1.70149449
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69822150
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67827188
47MAF_26560356_Chip-Seq_TH2_Human1.66313896
48MYB_26560356_Chip-Seq_TH1_Human1.65550078
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65279596
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.61986704
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61752061
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61508149
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58493860
54NCOR1_26117541_ChIP-Seq_K562_Human1.57412229
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55471347
56RUNX_20019798_ChIP-Seq_JUKART_Human1.55167970
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54657471
58E2F7_22180533_ChIP-Seq_HELA_Human1.51068385
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50609161
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50234057
61* LXR_22292898_ChIP-Seq_THP-1_Human1.48811311
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48110241
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46797960
64* BCOR_27268052_Chip-Seq_Bcells_Human1.44730235
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43129196
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42242215
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40927382
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.39989719
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.39519107
70* BCL6_27268052_Chip-Seq_Bcells_Human1.37244434
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31302925
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29671684
73GATA3_27048872_Chip-Seq_THYMUS_Human1.26125170
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23783338
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.23689708
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23293643
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23008758
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22426269
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19401568
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17422132
81* P68_20966046_ChIP-Seq_HELA_Human1.15320531
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11671272
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11636194
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.11489661
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08860583
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08815054
87CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07970538
88SPI1_20517297_ChIP-Seq_HL60_Human1.05764502
89KDM2B_26808549_Chip-Seq_K562_Human1.05288485
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03016209
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01747654
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01021320
93PU_27001747_Chip-Seq_BMDM_Mouse1.00898879
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98299609
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96526656
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91039002
97VDR_24787735_ChIP-Seq_THP-1_Human0.90839245
98RACK7_27058665_Chip-Seq_MCF-7_Human0.88924140
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88699257
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86582389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.69321293
2MP0003656_abnormal_erythrocyte_physiolo6.52148284
3MP0005083_abnormal_biliary_tract4.16123632
4MP0003303_peritoneal_inflammation4.11353729
5MP0003436_decreased_susceptibility_to3.21419762
6MP0003724_increased_susceptibility_to2.86058971
7MP0001545_abnormal_hematopoietic_system2.80741989
8MP0005397_hematopoietic_system_phenotyp2.80741989
9MP0009785_altered_susceptibility_to2.65606985
10MP0005025_abnormal_response_to2.58865130
11MP0002419_abnormal_innate_immunity2.57395239
12MP0009278_abnormal_bone_marrow2.54723653
13MP0000685_abnormal_immune_system2.41465303
14MP0005464_abnormal_platelet_physiology2.29567191
15MP0003191_abnormal_cellular_cholesterol2.22891817
16MP0008260_abnormal_autophagy2.15627342
17MP0001835_abnormal_antigen_presentation2.13827894
18MP0001790_abnormal_immune_system2.07905993
19MP0005387_immune_system_phenotype2.07905993
20MP0002398_abnormal_bone_marrow1.99831854
21MP0005000_abnormal_immune_tolerance1.94500843
22MP0002420_abnormal_adaptive_immunity1.93154139
23MP0001819_abnormal_immune_cell1.90199872
24MP0003172_abnormal_lysosome_physiology1.82309578
25MP0002405_respiratory_system_inflammati1.82091375
26MP0002132_abnormal_respiratory_system1.79955904
27MP0001800_abnormal_humoral_immune1.76934930
28MP0003300_gastrointestinal_ulcer1.74135913
29MP0002722_abnormal_immune_system1.69073778
30MP0002723_abnormal_immune_serum1.65577437
31MP0000689_abnormal_spleen_morphology1.65384933
32MP0002396_abnormal_hematopoietic_system1.60761516
33MP0006082_CNS_inflammation1.60419941
34MP0002452_abnormal_antigen_presenting1.60263760
35MP0005671_abnormal_response_to1.59555055
36MP0009333_abnormal_splenocyte_physiolog1.57679152
37MP0003763_abnormal_thymus_physiology1.56206775
38MP0005377_hearing/vestibular/ear_phenot1.54071009
39MP0003878_abnormal_ear_physiology1.54071009
40MP0000716_abnormal_immune_system1.50624887
41MP0002429_abnormal_blood_cell1.50413769
42MP0001533_abnormal_skeleton_physiology1.42374953
43MP0003045_fibrosis1.40460859
44MP0000703_abnormal_thymus_morphology1.31537372
45MP0000465_gastrointestinal_hemorrhage1.30872128
46MP0009764_decreased_sensitivity_to1.30426936
47MP0002148_abnormal_hypersensitivity_rea1.28638714
48MP0001845_abnormal_inflammatory_respons1.28597004
49MP0003866_abnormal_defecation1.27493558
50MP0010155_abnormal_intestine_physiology1.25262841
51MP0004947_skin_inflammation1.22710432
52MP0004808_abnormal_hematopoietic_stem1.22686768
53MP0005636_abnormal_mineral_homeostasis1.17402374
54MP0001851_eye_inflammation1.13956245
55MP0003828_pulmonary_edema1.11774003
56MP0005075_abnormal_melanosome_morpholog1.11322233
57MP0005451_abnormal_body_composition1.06963712
58MP0008469_abnormal_protein_level1.05528434
59MP0003183_abnormal_peptide_metabolism1.03252509
60MP0005076_abnormal_cell_differentiation1.00793792
61MP0000490_abnormal_crypts_of0.96546748
62MP0005310_abnormal_salivary_gland0.95746907
63MP0004381_abnormal_hair_follicle0.93617482
64MP0009931_abnormal_skin_appearance0.92414843
65MP0000858_altered_metastatic_potential0.92299595
66MP0004185_abnormal_adipocyte_glucose0.90588815
67MP0009765_abnormal_xenobiotic_induced0.89476147
68MP0004510_myositis0.89068069
69MP0009763_increased_sensitivity_to0.87874294
70MP0002166_altered_tumor_susceptibility0.85780395
71MP0001663_abnormal_digestive_system0.84997083
72MP0003186_abnormal_redox_activity0.83128092
73MP0003806_abnormal_nucleotide_metabolis0.82172427
74MP0000343_altered_response_to0.81020826
75MP0002138_abnormal_hepatobiliary_system0.80607647
76MP0005058_abnormal_lysosome_morphology0.77696214
77MP0004130_abnormal_muscle_cell0.76818431
78MP0002653_abnormal_ependyma_morphology0.75845743
79MP0003566_abnormal_cell_adhesion0.75238512
80MP0000015_abnormal_ear_pigmentation0.71817756
81MP0003075_altered_response_to0.71770947
82MP0000609_abnormal_liver_physiology0.69581746
83MP0005319_abnormal_enzyme/_coenzyme0.65246034
84MP0003795_abnormal_bone_structure0.62423953
85MP0005164_abnormal_response_to0.61245923
86MP0001873_stomach_inflammation0.61209924
87MP0002277_abnormal_respiratory_mucosa0.60543636
88MP0008995_early_reproductive_senescence0.59718905
89MP0002019_abnormal_tumor_incidence0.58815771
90MP0008874_decreased_physiological_sensi0.58586353
91MP0004883_abnormal_blood_vessel0.58559670
92MP0002095_abnormal_skin_pigmentation0.56682854
93MP0001986_abnormal_taste_sensitivity0.56652336
94MP0003879_abnormal_hair_cell0.54601440
95MP0003453_abnormal_keratinocyte_physiol0.54571173
96MP0000313_abnormal_cell_death0.54261905
97MP0002998_abnormal_bone_remodeling0.54241668
98MP0002332_abnormal_exercise_endurance0.52990076
99MP0000598_abnormal_liver_morphology0.50985143
100MP0003221_abnormal_cardiomyocyte_apopto0.49073359

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic anemia (HP:0001931)7.83664685
2Poikilocytosis (HP:0004447)7.26572232
3Microcytic anemia (HP:0001935)7.19372965
4Abnormal hemoglobin (HP:0011902)6.33106967
5Polycythemia (HP:0001901)4.93833943
6Eczematoid dermatitis (HP:0000976)4.80990373
7Reticulocytosis (HP:0001923)4.60899486
8Toxemia of pregnancy (HP:0100603)4.60399128
9Cholelithiasis (HP:0001081)4.52990943
10Recurrent abscess formation (HP:0002722)4.33894522
11Recurrent bacterial skin infections (HP:0005406)4.11147317
12Abnormal gallbladder morphology (HP:0012437)4.07782895
13Paralysis (HP:0003470)4.02802136
14Prolonged bleeding time (HP:0003010)3.90078661
15Abnormality of macrophages (HP:0004311)3.77644319
16Recurrent gram-negative bacterial infections (HP:0005420)3.68542016
17Acanthocytosis (HP:0001927)3.66716363
18Gastrointestinal infarctions (HP:0005244)3.46789832
19Obstructive lung disease (HP:0006536)3.38198439
20Chronic obstructive pulmonary disease (HP:0006510)3.38198439
21Myositis (HP:0100614)3.34474235
22Abnormality of iron homeostasis (HP:0011031)3.33743368
23Urticaria (HP:0001025)3.33109239
24Stomatitis (HP:0010280)3.28554182
25Diaphragmatic weakness (HP:0009113)3.24172855
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.03165608
27Petechiae (HP:0000967)2.98767866
28Abnormality of the gallbladder (HP:0005264)2.95517294
29Ileus (HP:0002595)2.94028223
30Abnormality of reticulocytes (HP:0004312)2.91196032
31Abnormality of transition element cation homeostasis (HP:0011030)2.83663619
32Osteomyelitis (HP:0002754)2.74878599
33Orchitis (HP:0100796)2.73960216
34Mediastinal lymphadenopathy (HP:0100721)2.73019221
35Meningitis (HP:0001287)2.72962265
36Epistaxis (HP:0000421)2.72900782
37Cellulitis (HP:0100658)2.71783032
38Gingivitis (HP:0000230)2.68421607
39Spontaneous hematomas (HP:0007420)2.65918861
40Elevated erythrocyte sedimentation rate (HP:0003565)2.61475409
41Recurrent skin infections (HP:0001581)2.61148366
42Hyperbilirubinemia (HP:0002904)2.60536453
43Increased IgE level (HP:0003212)2.59336407
44Recurrent fungal infections (HP:0002841)2.57785245
45Pustule (HP:0200039)2.56932141
46Abnormality of the fingertips (HP:0001211)2.52309122
47Pallor (HP:0000980)2.50707725
48Abnormal gallbladder physiology (HP:0012438)2.48269604
49Cholecystitis (HP:0001082)2.48269604
50Abnormal platelet volume (HP:0011876)2.43644191
51Increased serum ferritin (HP:0003281)2.41755731
52Optic neuritis (HP:0100653)2.40862716
53Retrobulbar optic neuritis (HP:0100654)2.40862716
54Osteomalacia (HP:0002749)2.36762234
55Encephalitis (HP:0002383)2.35378945
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35177974
57Cutaneous photosensitivity (HP:0000992)2.34824944
58Keratoconjunctivitis sicca (HP:0001097)2.34470943
59Anorexia (HP:0002039)2.31995828
60Gingival bleeding (HP:0000225)2.31090121
61Vasculitis (HP:0002633)2.21977840
62Hypertensive crisis (HP:0100735)2.21218061
63Episodic fever (HP:0001954)2.15924549
64Keratoconjunctivitis (HP:0001096)2.14814428
65Recurrent cutaneous fungal infections (HP:0011370)2.08960832
66Chronic mucocutaneous candidiasis (HP:0002728)2.08960832
67Inflammation of the large intestine (HP:0002037)2.07455297
68Gastrointestinal inflammation (HP:0004386)2.01297741
69Hypochromic microcytic anemia (HP:0004840)12.9320161
70Abnormality of the heme biosynthetic pathway (HP:0010472)12.4890674
71Abnormality of the pericardium (HP:0001697)1.97890438
72Chest pain (HP:0100749)1.97546348
73Hepatosplenomegaly (HP:0001433)1.95186980
74Leukocytosis (HP:0001974)1.92373479
75Gastrointestinal dysmotility (HP:0002579)1.91908182
76Purpura (HP:0000979)1.91046576
77Granulocytopenia (HP:0001913)1.88059482
78Metaphyseal cupping (HP:0003021)1.87317104
79Slow saccadic eye movements (HP:0000514)1.86292212
80Recurrent viral infections (HP:0004429)1.84310844
81Thrombophlebitis (HP:0004418)1.82619342
82Autoimmune thrombocytopenia (HP:0001973)1.81342201
83Pulmonary infiltrates (HP:0002113)1.78355665
84Increased IgM level (HP:0003496)1.77184211
85Hypertriglyceridemia (HP:0002155)1.76533361
86Paresthesia (HP:0003401)1.75972908
87Abnormality of T cell physiology (HP:0011840)1.73753614
88Increased mean platelet volume (HP:0011877)1.72619707
89Splenomegaly (HP:0001744)1.72505928
90Skin rash (HP:0000988)1.69960592
91Nasal polyposis (HP:0100582)1.69127720
92Panhypogammaglobulinemia (HP:0003139)1.68393802
93Difficulty running (HP:0009046)1.68222722
94Impaired platelet aggregation (HP:0003540)1.67751865
95Abnormal platelet function (HP:0011869)1.67751865
96Hepatocellular carcinoma (HP:0001402)1.67432434
97Nausea (HP:0002018)1.65248916
98Bruising susceptibility (HP:0000978)1.65021054
99Sepsis (HP:0100806)1.65010338
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63082392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.46752712
2TAOK13.82052823
3RIPK43.75919900
4PRPF4B3.67492918
5GRK63.50597754
6EIF2AK13.37890604
7MAP3K113.20810625
8TAOK22.93808350
9MAP3K32.91496847
10TNK22.78006372
11ERN12.66243210
12MAP4K12.60839794
13IRAK42.45933942
14FES1.94072547
15SYK1.66475722
16FGR1.64021499
17BLK1.58675010
18TYK21.57974502
19ZAP701.56408240
20BTK1.54524551
21CSK1.47931709
22MAP3K11.42252715
23HCK1.40495601
24MARK31.36951210
25BMX1.31495780
26PTK2B1.27999571
27TRIB31.24107296
28EPHB11.23152907
29PIM11.17970062
30LYN1.16525951
31IKBKE1.10651763
32SMG11.10294198
33JAK21.09602595
34CLK11.03145183
35MAP3K51.02939340
36SIK31.01891825
37DYRK31.01623852
38MAP3K61.01454851
39TBK10.98996115
40HIPK20.94410261
41MARK20.93085939
42SIK20.91960879
43PRKD20.90741555
44STK110.90691795
45TEC0.90459690
46KSR20.84671288
47STK40.83294064
48RPS6KC10.82817638
49RPS6KL10.82817638
50WNK10.82423988
51PTK60.81562290
52MAP2K40.80921570
53YES10.80518116
54JAK30.78300385
55SGK30.78237871
56TESK20.76814557
57CDK190.74367368
58LCK0.74128744
59RPS6KA60.69913920
60MAP3K100.69544743
61DYRK1B0.68058165
62MAP3K80.67304455
63TXK0.65821613
64IKBKB0.65671641
65MAPK120.62339595
66PDPK10.61655125
67PDK10.58384322
68ITK0.57469094
69SIK10.54435035
70RPS6KA50.52540316
71CAMK1D0.52092111
72SGK20.50558504
73MAP2K10.49416898
74KIT0.48961026
75TRPM70.48810255
76ICK0.47948090
77RPS6KA20.47614026
78FYN0.45962371
79MAP3K140.45383561
80MAP2K20.45321772
81CDK120.44091642
82KSR10.43621753
83MAP3K70.42637039
84PRKCQ0.41817191
85DAPK20.41645270
86CSF1R0.41340572
87MAP3K130.41170917
88MAPKAPK20.40901238
89GRK50.38701200
90CDK40.38165415
91PRKAA20.35752050
92TAOK30.35402589
93LRRK20.34300505
94SGK10.33535609
95RET0.33438285
96PRKCZ0.33382336
97JAK10.33138502
98STK380.33130841
99MAPK40.32883489
100MAPK110.32106783

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051444.32832112
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.87421261
3African trypanosomiasis_Homo sapiens_hsa051433.14002946
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.95475807
5Osteoclast differentiation_Homo sapiens_hsa043802.61984238
6Leishmaniasis_Homo sapiens_hsa051402.22935067
7Staphylococcus aureus infection_Homo sapiens_hsa051502.00840941
8Hematopoietic cell lineage_Homo sapiens_hsa046401.92516809
9Acute myeloid leukemia_Homo sapiens_hsa052211.85363181
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84504612
11B cell receptor signaling pathway_Homo sapiens_hsa046621.84374853
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76985146
13Tuberculosis_Homo sapiens_hsa051521.73871943
14Asthma_Homo sapiens_hsa053101.73422449
15Non-small cell lung cancer_Homo sapiens_hsa052231.68267992
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61863705
17Pancreatic cancer_Homo sapiens_hsa052121.55213573
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45171923
19Regulation of autophagy_Homo sapiens_hsa041401.45016231
20Primary immunodeficiency_Homo sapiens_hsa053401.44466284
21Chronic myeloid leukemia_Homo sapiens_hsa052201.44196992
22Measles_Homo sapiens_hsa051621.41362661
23Collecting duct acid secretion_Homo sapiens_hsa049661.41197135
24Chemokine signaling pathway_Homo sapiens_hsa040621.40585176
25Herpes simplex infection_Homo sapiens_hsa051681.34431103
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33757893
27Graft-versus-host disease_Homo sapiens_hsa053321.30095910
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28959223
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.25878257
30Allograft rejection_Homo sapiens_hsa053301.22180350
31Influenza A_Homo sapiens_hsa051641.19202214
32Toxoplasmosis_Homo sapiens_hsa051451.18393081
33Phagosome_Homo sapiens_hsa041451.18094996
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.17402158
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.16028984
36Hepatitis C_Homo sapiens_hsa051601.15020532
37Autoimmune thyroid disease_Homo sapiens_hsa053201.13855729
38T cell receptor signaling pathway_Homo sapiens_hsa046601.12014158
39Platelet activation_Homo sapiens_hsa046111.11366803
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.09212585
41Nitrogen metabolism_Homo sapiens_hsa009101.08449438
42Hepatitis B_Homo sapiens_hsa051611.05603818
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02368662
44Renal cell carcinoma_Homo sapiens_hsa052111.02312381
45FoxO signaling pathway_Homo sapiens_hsa040681.00484161
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99379342
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96191282
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.95876185
49Apoptosis_Homo sapiens_hsa042100.95470362
50TNF signaling pathway_Homo sapiens_hsa046680.93382133
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90017020
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89098944
53Legionellosis_Homo sapiens_hsa051340.85751799
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85067037
55Antigen processing and presentation_Homo sapiens_hsa046120.83712576
56Viral carcinogenesis_Homo sapiens_hsa052030.83560869
57VEGF signaling pathway_Homo sapiens_hsa043700.81555374
58Other glycan degradation_Homo sapiens_hsa005110.77771981
59Endometrial cancer_Homo sapiens_hsa052130.76008221
60Endocytosis_Homo sapiens_hsa041440.75712429
61Type I diabetes mellitus_Homo sapiens_hsa049400.74462067
62HIF-1 signaling pathway_Homo sapiens_hsa040660.73235009
63Notch signaling pathway_Homo sapiens_hsa043300.72216462
64Shigellosis_Homo sapiens_hsa051310.71878319
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71758123
66Systemic lupus erythematosus_Homo sapiens_hsa053220.70739497
67Choline metabolism in cancer_Homo sapiens_hsa052310.70251529
68mTOR signaling pathway_Homo sapiens_hsa041500.68240804
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68167117
70Prolactin signaling pathway_Homo sapiens_hsa049170.65354103
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64485374
72Salmonella infection_Homo sapiens_hsa051320.64130596
73Type II diabetes mellitus_Homo sapiens_hsa049300.63980236
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.63724936
75HTLV-I infection_Homo sapiens_hsa051660.63504337
76Bladder cancer_Homo sapiens_hsa052190.63304053
77Epstein-Barr virus infection_Homo sapiens_hsa051690.61349768
78Inositol phosphate metabolism_Homo sapiens_hsa005620.60519234
79Viral myocarditis_Homo sapiens_hsa054160.57814922
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57443319
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56593273
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.54773521
83ABC transporters_Homo sapiens_hsa020100.54266279
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.53978584
85Pertussis_Homo sapiens_hsa051330.53186853
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.52882320
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52838721
88Lysosome_Homo sapiens_hsa041420.52372285
89Prostate cancer_Homo sapiens_hsa052150.51676830
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51603739
91Glioma_Homo sapiens_hsa052140.51122213
92Amoebiasis_Homo sapiens_hsa051460.50484896
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50306902
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49819857
95Pentose phosphate pathway_Homo sapiens_hsa000300.49606702
96Insulin resistance_Homo sapiens_hsa049310.45226608
97Small cell lung cancer_Homo sapiens_hsa052220.44929181
98AMPK signaling pathway_Homo sapiens_hsa041520.44550235
99GnRH signaling pathway_Homo sapiens_hsa049120.43874886
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42830878

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