HBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin catabolic process (GO:0009111)4.53714731
2fat-soluble vitamin catabolic process (GO:0042363)4.53714731
3positive regulation of gamma-delta T cell activation (GO:0046645)4.33467616
4regulation of memory T cell differentiation (GO:0043380)4.15273596
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04065432
6negative regulation of cell killing (GO:0031342)4.04065432
7production of molecular mediator involved in inflammatory response (GO:0002532)3.48690016
8regulation of gamma-delta T cell activation (GO:0046643)3.48092822
9signal peptide processing (GO:0006465)3.40761740
10negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.36780406
11regulation of gamma-delta T cell differentiation (GO:0045586)3.33939735
12negative regulation of T cell mediated immunity (GO:0002710)3.28601668
13positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27800723
14regulation of T cell mediated cytotoxicity (GO:0001914)3.27723962
15neutrophil activation involved in immune response (GO:0002283)3.26695883
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25040910
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19481724
18cellular extravasation (GO:0045123)3.12877670
19regulation of B cell receptor signaling pathway (GO:0050855)3.12505471
20negative regulation of fatty acid biosynthetic process (GO:0045717)3.06428202
21T-helper 1 type immune response (GO:0042088)3.06266233
22positive regulation of interleukin-17 production (GO:0032740)3.02029160
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.00391739
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98702383
25positive regulation of T-helper 1 type immune response (GO:0002827)2.98224563
26negative regulation of interleukin-12 production (GO:0032695)2.98078144
27tryptophan metabolic process (GO:0006568)2.92182635
28regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.92058803
29interleukin-6-mediated signaling pathway (GO:0070102)2.89720900
30regulation of T-helper 1 type immune response (GO:0002825)2.87074919
31indole-containing compound catabolic process (GO:0042436)2.86416356
32indolalkylamine catabolic process (GO:0046218)2.86416356
33tryptophan catabolic process (GO:0006569)2.86416356
34negative regulation of complement activation (GO:0045916)2.84866590
35regulation of alpha-beta T cell proliferation (GO:0046640)2.83932880
36regulation of regulatory T cell differentiation (GO:0045589)2.81094546
37detection of molecule of bacterial origin (GO:0032490)2.80729670
38establishment of protein localization to Golgi (GO:0072600)2.80057993
39positive regulation of type 2 immune response (GO:0002830)2.79780411
40positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79592408
41protein targeting to Golgi (GO:0000042)2.79101179
42negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.77635163
43positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74596528
44neutrophil mediated immunity (GO:0002446)2.74440706
45negative regulation of T-helper cell differentiation (GO:0045623)2.72624925
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72624925
47positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71649830
48regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.69161205
49cellular response to interleukin-15 (GO:0071350)2.68924584
50activated T cell proliferation (GO:0050798)2.68658584
51cell wall macromolecule metabolic process (GO:0044036)2.67552376
52response to interleukin-15 (GO:0070672)2.67288111
53cell wall macromolecule catabolic process (GO:0016998)2.64982430
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.64489297
55cellular response to exogenous dsRNA (GO:0071360)2.63595732
56positive regulation of defense response to virus by host (GO:0002230)2.62803075
57negative regulation of adaptive immune response (GO:0002820)2.62573880
58regulation of leukocyte mediated cytotoxicity (GO:0001910)2.61461724
59valine metabolic process (GO:0006573)2.58619552
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55453550
61negative T cell selection (GO:0043383)2.54649333
62positive regulation of natural killer cell activation (GO:0032816)2.54222604
63neural crest cell development (GO:0014032)2.53830704
64negative thymic T cell selection (GO:0045060)2.53561133
65regulation of interleukin-17 production (GO:0032660)2.53501755
66retinoic acid metabolic process (GO:0042573)2.52537220
67negative regulation of protein activation cascade (GO:2000258)2.51954544
68dendritic cell migration (GO:0036336)2.51804732
69positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.51632756
70positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.50671258
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.50656408
72aromatic amino acid family catabolic process (GO:0009074)2.50395889
73positive regulation of granulocyte differentiation (GO:0030854)2.49847423
74regulation of interferon-beta biosynthetic process (GO:0045357)2.49553063
75poly(A)+ mRNA export from nucleus (GO:0016973)2.49230374
76negative regulation of leukocyte mediated immunity (GO:0002704)2.48785509
77positive regulation of interferon-alpha production (GO:0032727)2.48672776
78antigen processing and presentation of endogenous antigen (GO:0019883)2.48071307
79regulation of cell killing (GO:0031341)2.47188970
80negative regulation of humoral immune response (GO:0002921)2.46146205
81regulation of T-helper cell differentiation (GO:0045622)2.45168979
82positive regulation of B cell differentiation (GO:0045579)2.40811579
83detection of bacterium (GO:0016045)2.40533606
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.39404613
85negative regulation of lipid storage (GO:0010888)2.39238727
86regulation of protein glycosylation (GO:0060049)2.38768073
87positive regulation of interleukin-1 beta secretion (GO:0050718)2.37927687
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37484135
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37484135
90regulation of T cell mediated immunity (GO:0002709)2.37360255
91regulation of activation of Janus kinase activity (GO:0010533)2.37354868
92positive regulation of T-helper cell differentiation (GO:0045624)2.37336058
93interferon-gamma-mediated signaling pathway (GO:0060333)2.36799750
94positive regulation of T cell mediated immunity (GO:0002711)2.36402873
95detection of external biotic stimulus (GO:0098581)2.35100391
96neutrophil activation (GO:0042119)2.34999866
97positive regulation of cell killing (GO:0031343)2.34589093
98microglial cell activation (GO:0001774)2.34279959
99positive regulation by symbiont of host defense response (GO:0052509)2.34024124
100modulation by symbiont of host defense response (GO:0052031)2.34024124
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34024124
102modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34024124
103positive regulation by organism of defense response of other organism involved in symbiotic interact2.34024124
104modulation by symbiont of host immune response (GO:0052553)2.34024124
105positive regulation of T cell cytokine production (GO:0002726)2.33985776
106amyloid precursor protein catabolic process (GO:0042987)2.32913884
107G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.32872774
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.31179852
109growth hormone receptor signaling pathway (GO:0060396)2.30645651
110type I interferon signaling pathway (GO:0060337)2.30555124
111cellular response to type I interferon (GO:0071357)2.30555124
112response to type I interferon (GO:0034340)2.30461759
113regulation of interferon-alpha production (GO:0032647)2.29872324
114negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.29622003
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.29033336
116phagocytosis, recognition (GO:0006910)2.27945049
117cranial suture morphogenesis (GO:0060363)2.26034333
118granulocyte activation (GO:0036230)2.22257263
119positive regulation of interferon-beta production (GO:0032728)2.19864909
120cellular biogenic amine catabolic process (GO:0042402)2.19515805
121amine catabolic process (GO:0009310)2.19515805
122detection of other organism (GO:0098543)2.15965248
123kynurenine metabolic process (GO:0070189)2.14701463
124positive regulation of antigen processing and presentation (GO:0002579)2.12839640
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.10746190
126macrophage activation involved in immune response (GO:0002281)2.09860157
127cellular response to growth hormone stimulus (GO:0071378)2.09756520
128I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.09184468
129fatty acid beta-oxidation (GO:0006635)2.08776811
130cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.08776236
131positive regulation of cholesterol efflux (GO:0010875)2.08582661
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.08424234
133L-phenylalanine catabolic process (GO:0006559)2.08424234
134nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.08144501
135immunoglobulin mediated immune response (GO:0016064)2.07421079
136regulation of hexokinase activity (GO:1903299)2.07160517
137regulation of glucokinase activity (GO:0033131)2.07160517
138phospholipid efflux (GO:0033700)2.06608079
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.06365170
140positive regulation of keratinocyte differentiation (GO:0045618)2.04863072
141indolalkylamine metabolic process (GO:0006586)2.04532646
142negative regulation of mast cell activation (GO:0033004)2.04212621
143positive regulation of sterol transport (GO:0032373)2.03561565
144positive regulation of cholesterol transport (GO:0032376)2.03561565
145regulation of cholesterol storage (GO:0010885)2.03293598
146positive regulation of natural killer cell differentiation (GO:0032825)2.03231662
147mesenchymal cell development (GO:0014031)2.03165619
148dendritic cell chemotaxis (GO:0002407)2.01263825
149toxin transport (GO:1901998)1.99543522
150diterpenoid biosynthetic process (GO:0016102)1.98235598
151regulation of interleukin-8 secretion (GO:2000482)1.97859234
152detection of biotic stimulus (GO:0009595)1.97759505
153interferon-gamma production (GO:0032609)1.97031064
154positive regulation of interleukin-12 production (GO:0032735)1.95827297
155protein carboxylation (GO:0018214)1.95662802
156peptidyl-glutamic acid carboxylation (GO:0017187)1.95662802
157NIK/NF-kappaB signaling (GO:0038061)1.95314533
158negative regulation of viral genome replication (GO:0045071)1.94529398
159response to peptidoglycan (GO:0032494)1.94457801
160positive regulation of T cell migration (GO:2000406)1.94380036
161myeloid dendritic cell activation (GO:0001773)1.93985884
162Golgi transport vesicle coating (GO:0048200)1.93081705
163COPI coating of Golgi vesicle (GO:0048205)1.93081705
164gland morphogenesis (GO:0022612)1.92003203
165myoblast migration (GO:0051451)1.90983381
166negative regulation of retinoic acid receptor signaling pathway (GO:0048387)1.90846482
167phosphate ion homeostasis (GO:0055062)1.90814230
168trivalent inorganic anion homeostasis (GO:0072506)1.90814230
169cellular response to thyroid hormone stimulus (GO:0097067)1.90671634
170positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.89340665
171positive regulation of monocyte chemotaxis (GO:0090026)1.89111885
172regulation of RIG-I signaling pathway (GO:0039535)1.88889961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.06792939
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49479287
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.38434664
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.25007677
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15573731
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.05685821
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88092907
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78310146
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.56622946
10GATA1_22025678_ChIP-Seq_K562_Human2.38748189
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31338090
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.29697131
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29236402
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.27115519
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.18289649
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14883249
17VDR_22108803_ChIP-Seq_LS180_Human2.13356012
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13331769
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13072935
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11018287
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09351425
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04162944
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.03216708
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.01544937
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99896663
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96448512
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88239950
28* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86205551
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.81713539
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.77660562
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76180950
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73941936
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68985559
34CLOCK_20551151_ChIP-Seq_293T_Human1.68404473
35ZNF274_21170338_ChIP-Seq_K562_Hela1.68404381
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67970746
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65896493
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65801559
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57899346
40* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57690485
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.56033163
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52829960
43* ER_23166858_ChIP-Seq_MCF-7_Human1.49696720
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48168670
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47934129
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.46850182
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45553940
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45111969
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43286907
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42083697
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.41719606
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41467619
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38609641
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38281545
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37977015
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37971648
57* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36885740
58ELK1_19687146_ChIP-ChIP_HELA_Human1.34343964
59IGF1R_20145208_ChIP-Seq_DFB_Human1.33657158
60* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33223364
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32335269
62SPI1_23547873_ChIP-Seq_NB4_Human1.31629162
63* MYB_26560356_Chip-Seq_TH2_Human1.30652248
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.29705041
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29226853
66GBX2_23144817_ChIP-Seq_PC3_Human1.28077366
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26458826
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.24521824
69* EGR1_19374776_ChIP-ChIP_THP-1_Human1.23251435
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.20059802
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19860034
72* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19743163
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18403813
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17707014
75CDX2_22108803_ChIP-Seq_LS180_Human1.17343442
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15828272
77P300_19829295_ChIP-Seq_ESCs_Human1.15102072
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14843230
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14820863
80PU_27001747_Chip-Seq_BMDM_Mouse1.14295987
81RUNX_20019798_ChIP-Seq_JUKART_Human1.13845903
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13090468
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.12462573
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11596276
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11135451
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.09912309
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.09699227
88BCAT_22108803_ChIP-Seq_LS180_Human1.09155209
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09103126
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08461668
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08461668
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.07315120
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07262171
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07260537
95CBP_20019798_ChIP-Seq_JUKART_Human1.07260537
96* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06411751
97* SOX2_20726797_ChIP-Seq_SW620_Human1.05893614
98PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05819913
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05428401
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.05409560
101SALL4_22934838_ChIP-ChIP_CD34+_Human1.05203876
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04783197
103TAF15_26573619_Chip-Seq_HEK293_Human1.04527428
104* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03239568
105* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03239568
106SPI1_23127762_ChIP-Seq_K562_Human1.02578273
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02516854
108* GATA3_26560356_Chip-Seq_TH2_Human1.01423205
109SMAD4_21799915_ChIP-Seq_A2780_Human1.01309765
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.00564552
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00113036
112* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99931086
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99566927
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99450763
115GATA4_25053715_ChIP-Seq_YYC3_Human0.99370420
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98985594
117* SMRT_27268052_Chip-Seq_Bcells_Human0.98655028
118NANOG_19829295_ChIP-Seq_ESCs_Human0.98503329
119SOX2_19829295_ChIP-Seq_ESCs_Human0.98503329
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98164668
121MYB_26560356_Chip-Seq_TH1_Human0.97877722
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97839068
123STAT3_23295773_ChIP-Seq_U87_Human0.97717222
124* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97044940
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96933752
126* CJUN_26792858_Chip-Seq_BT549_Human0.96831058
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96743930
128* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96480234
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96165981
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96088676
131SCL_19346495_ChIP-Seq_HPC-7_Human0.95589652
132* FOXO3_23340844_ChIP-Seq_DLD1_Human0.94811633
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94166252
134* TFEB_21752829_ChIP-Seq_HELA_Human0.94037270
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93565192
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93558492
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93408730
138* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93194435
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91362614
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91241472
141TP63_23658742_ChIP-Seq_EP156T_Human0.90517301
142E2F7_22180533_ChIP-Seq_HELA_Human0.90135299
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90088647
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90025098
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89933032
146P53_22387025_ChIP-Seq_ESCs_Mouse0.89665854
147GATA2_19941826_ChIP-Seq_K562_Human0.89649691
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89441516
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88963438
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88847725
151* AR_25329375_ChIP-Seq_VCAP_Human0.88771970
152VDR_24787735_ChIP-Seq_THP-1_Human0.87988987
153* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87897809
154* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87496522
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86786002
156GATA3_27048872_Chip-Seq_THYMUS_Human0.86673177
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83315865
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82910349
159MAF_26560356_Chip-Seq_TH1_Human0.81019725
160* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80728723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.88449174
2MP0003303_peritoneal_inflammation2.57737823
3MP0002009_preneoplasia2.43795835
4MP0003300_gastrointestinal_ulcer2.40670757
5MP0002139_abnormal_hepatobiliary_system2.33860783
6MP0003191_abnormal_cellular_cholesterol2.21942630
7MP0003656_abnormal_erythrocyte_physiolo2.18080393
8MP0009785_altered_susceptibility_to2.05756535
9MP0003724_increased_susceptibility_to1.98496471
10MP0002138_abnormal_hepatobiliary_system1.89106511
11MP0002148_abnormal_hypersensitivity_rea1.86038796
12MP0002166_altered_tumor_susceptibility1.85642669
13MP0005365_abnormal_bile_salt1.78971271
14MP0001545_abnormal_hematopoietic_system1.76919546
15MP0005397_hematopoietic_system_phenotyp1.76919546
16MP0008004_abnormal_stomach_pH1.74740675
17MP0003941_abnormal_skin_development1.69912878
18MP0004782_abnormal_surfactant_physiolog1.68355424
19MP0008438_abnormal_cutaneous_collagen1.67019026
20MP0005085_abnormal_gallbladder_physiolo1.65706620
21MP0000465_gastrointestinal_hemorrhage1.62371315
22MP0002132_abnormal_respiratory_system1.62298781
23MP0002419_abnormal_innate_immunity1.61753361
24MP0000685_abnormal_immune_system1.58916577
25MP0003195_calcinosis1.56722730
26MP0005387_immune_system_phenotype1.56585036
27MP0001790_abnormal_immune_system1.56585036
28MP0008877_abnormal_DNA_methylation1.55833120
29MP0005671_abnormal_response_to1.55809528
30MP0005075_abnormal_melanosome_morpholog1.54938269
31MP0002006_tumorigenesis1.54867937
32MP0010368_abnormal_lymphatic_system1.51291235
33MP0001879_abnormal_lymphatic_vessel1.48420624
34MP0000569_abnormal_digit_pigmentation1.48205169
35MP0003787_abnormal_imprinting1.47330282
36MP0003950_abnormal_plasma_membrane1.46877022
37MP0005025_abnormal_response_to1.46588244
38MP0008260_abnormal_autophagy1.46437713
39MP0003436_decreased_susceptibility_to1.45410414
40MP0005058_abnormal_lysosome_morphology1.41175940
41MP0005360_urolithiasis1.38117820
42MP0004484_altered_response_of1.37189605
43MP0001853_heart_inflammation1.36787621
44MP0002254_reproductive_system_inflammat1.35999380
45MP0002452_abnormal_antigen_presenting1.31619616
46MP0005164_abnormal_response_to1.30755128
47MP0009764_decreased_sensitivity_to1.30400688
48MP0003172_abnormal_lysosome_physiology1.28920933
49MP0005167_abnormal_blood-brain_barrier1.28189569
50MP0005000_abnormal_immune_tolerance1.26354563
51MP0001800_abnormal_humoral_immune1.26251651
52MP0003646_muscle_fatigue1.26123709
53MP0002405_respiratory_system_inflammati1.24269799
54MP0002723_abnormal_immune_serum1.22477419
55MP0003186_abnormal_redox_activity1.20493697
56MP0004883_abnormal_blood_vessel1.18445087
57MP0003828_pulmonary_edema1.18405126
58MP0001819_abnormal_immune_cell1.15336419
59MP0005275_abnormal_skin_tensile1.14925031
60MP0003943_abnormal_hepatobiliary_system1.14607843
61MP0006054_spinal_hemorrhage1.14288599
62MP0002098_abnormal_vibrissa_morphology1.13458953
63MP0002420_abnormal_adaptive_immunity1.13224608
64MP0009333_abnormal_splenocyte_physiolog1.13077477
65MP0008007_abnormal_cellular_replicative1.12907162
66MP0002277_abnormal_respiratory_mucosa1.12803104
67MP0005410_abnormal_fertilization1.11357695
68MP0009765_abnormal_xenobiotic_induced1.10315781
69MP0000383_abnormal_hair_follicle1.10064597
70MP0006082_CNS_inflammation1.08602217
71MP0001845_abnormal_inflammatory_respons1.07447467
72MP0002933_joint_inflammation1.06181860
73MP0003763_abnormal_thymus_physiology1.05333826
74MP0002332_abnormal_exercise_endurance1.04381558
75MP0010155_abnormal_intestine_physiology1.04208853
76MP0003806_abnormal_nucleotide_metabolis1.02570405
77MP0005408_hypopigmentation1.01567758
78MP0001533_abnormal_skeleton_physiology1.00470466
79MP0002060_abnormal_skin_morphology0.99162094
80MP0009840_abnormal_foam_cell0.98988692
81MP0004947_skin_inflammation0.96918414
82MP0008469_abnormal_protein_level0.96662715
83MP0005503_abnormal_tendon_morphology0.95614351
84MP0000767_abnormal_smooth_muscle0.92859897
85MP0003252_abnormal_bile_duct0.92340368
86MP0004381_abnormal_hair_follicle0.91714963
87MP0000015_abnormal_ear_pigmentation0.90667676
88MP0002168_other_aberrant_phenotype0.90647718
89MP0000716_abnormal_immune_system0.90156649
90MP0003183_abnormal_peptide_metabolism0.89992716
91MP0003448_altered_tumor_morphology0.89757234
92MP0003453_abnormal_keratinocyte_physiol0.89635016
93MP0003045_fibrosis0.89140391
94MP0005670_abnormal_white_adipose0.88417808
95MP0004147_increased_porphyrin_level0.87926124
96MP0000609_abnormal_liver_physiology0.87066967
97MP0001243_abnormal_dermal_layer0.86044018
98MP0008995_early_reproductive_senescence0.86008314
99MP0002998_abnormal_bone_remodeling0.85157817
100MP0003866_abnormal_defecation0.85086365
101MP0005390_skeleton_phenotype0.84647296
102MP0000249_abnormal_blood_vessel0.84305068
103MP0005084_abnormal_gallbladder_morpholo0.81532489
104MP0002398_abnormal_bone_marrow0.80771022
105MP0004019_abnormal_vitamin_homeostasis0.79985872
106MP0000343_altered_response_to0.78848532
107MP0010329_abnormal_lipoprotein_level0.78699221
108MP0005166_decreased_susceptibility_to0.77985529
109MP0010678_abnormal_skin_adnexa0.77460211
110MP0009763_increased_sensitivity_to0.76883670
111MP0009643_abnormal_urine_homeostasis0.76395543
112MP0005310_abnormal_salivary_gland0.76139813
113MP0009697_abnormal_copulation0.76115440
114MP0002938_white_spotting0.76055250
115MP0000689_abnormal_spleen_morphology0.75861575
116MP0003567_abnormal_fetal_cardiomyocyte0.75702539
117MP0001851_eye_inflammation0.75055821
118MP0009053_abnormal_anal_canal0.75044128
119MP0001666_abnormal_nutrient_absorption0.74695689
120MP0005174_abnormal_tail_pigmentation0.74490272
121MP0002429_abnormal_blood_cell0.74083260
122MP0009384_cardiac_valve_regurgitation0.73925151
123MP0003795_abnormal_bone_structure0.73905773
124MP0001764_abnormal_homeostasis0.73287227
125MP0002396_abnormal_hematopoietic_system0.72913495
126MP0001542_abnormal_bone_strength0.72158092
127MP0005508_abnormal_skeleton_morphology0.72106534
128MP0003011_delayed_dark_adaptation0.70940274
129MP0003566_abnormal_cell_adhesion0.70771035
130MP0003221_abnormal_cardiomyocyte_apopto0.70669467
131MP0010386_abnormal_urinary_bladder0.70238738
132MP0004808_abnormal_hematopoietic_stem0.69672932
133MP0002136_abnormal_kidney_physiology0.69389065
134MP0000858_altered_metastatic_potential0.69383799
135MP0000703_abnormal_thymus_morphology0.68452980
136MP0000598_abnormal_liver_morphology0.68207003
137MP0000371_diluted_coat_color0.68137539
138MP0005464_abnormal_platelet_physiology0.68065008
139MP0002722_abnormal_immune_system0.67752443
140MP0005367_renal/urinary_system_phenotyp0.67504761
141MP0000516_abnormal_urinary_system0.67504761
142MP0005257_abnormal_intraocular_pressure0.66867315
143MP0000427_abnormal_hair_cycle0.66795988

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.39915571
2Vacuolated lymphocytes (HP:0001922)3.55288468
3Generalized aminoaciduria (HP:0002909)3.33324793
4T lymphocytopenia (HP:0005403)3.21880535
5Systemic lupus erythematosus (HP:0002725)3.10610626
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.07969090
7Myositis (HP:0100614)2.98818471
8Eczematoid dermatitis (HP:0000976)2.98104179
9Gastrointestinal infarctions (HP:0005244)2.96610213
10Hemoptysis (HP:0002105)2.93653342
11Pulmonary infiltrates (HP:0002113)2.85310669
12Optic neuritis (HP:0100653)2.84156094
13Retrobulbar optic neuritis (HP:0100654)2.84156094
14Leukocytosis (HP:0001974)2.83434847
15Orchitis (HP:0100796)2.77747476
16Keratitis (HP:0000491)2.71908950
17Gangrene (HP:0100758)2.67124370
18Prolonged partial thromboplastin time (HP:0003645)2.63689022
19Abnormality of the heme biosynthetic pathway (HP:0010472)2.57715348
20Eosinophilia (HP:0001880)2.55833702
21Renal cortical cysts (HP:0000803)2.54168160
22Recurrent gram-negative bacterial infections (HP:0005420)2.53469439
23Keratoconjunctivitis sicca (HP:0001097)2.49871771
24Abnormality of fatty-acid metabolism (HP:0004359)2.48495401
25Albinism (HP:0001022)2.46411306
26Conjugated hyperbilirubinemia (HP:0002908)2.46141838
27Abnormality of T cells (HP:0002843)2.44467538
28Recurrent abscess formation (HP:0002722)2.44397288
29Recurrent bacterial skin infections (HP:0005406)2.44111651
30Prolonged bleeding time (HP:0003010)2.43705404
31Hypoglycemic coma (HP:0001325)2.43510959
32Spontaneous hematomas (HP:0007420)2.41787331
33Stomach cancer (HP:0012126)2.41767385
34Hypochromic microcytic anemia (HP:0004840)2.41373377
35Periodontitis (HP:0000704)2.41167966
36Polyneuropathy (HP:0001271)2.40793109
37Syringomyelia (HP:0003396)2.38438996
38Spinal cord lesions (HP:0100561)2.38438996
39Alveolar cell carcinoma (HP:0006519)2.37662669
40Abnormality of eosinophils (HP:0001879)2.36412811
41Anorexia (HP:0002039)2.36410461
42Facial diplegia (HP:0001349)2.34019213
43Neoplasm of the tracheobronchial system (HP:0100552)2.32594653
44Pulmonary embolism (HP:0002204)2.32572907
45Keratoconjunctivitis (HP:0001096)2.27391316
46Elevated erythrocyte sedimentation rate (HP:0003565)2.25774529
47Nausea (HP:0002018)2.24518386
48Pancreatic islet-cell hyperplasia (HP:0004510)2.24139165
49Prolonged neonatal jaundice (HP:0006579)2.23873377
50Thrombocytosis (HP:0001894)2.21519566
51Thyroiditis (HP:0100646)2.20796595
52Nonimmune hydrops fetalis (HP:0001790)2.20590767
53Meningitis (HP:0001287)2.19882690
54Pancreatic cysts (HP:0001737)2.18722100
55Abnormality of glycolipid metabolism (HP:0010969)2.18203743
56Abnormality of liposaccharide metabolism (HP:0010968)2.18203743
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.18203743
58Increased IgE level (HP:0003212)2.17090974
59IgG deficiency (HP:0004315)2.16067606
60Chronic hepatic failure (HP:0100626)2.15670207
61Prostate neoplasm (HP:0100787)2.14269171
62Granulocytopenia (HP:0001913)2.12964587
63Acne (HP:0001061)2.12886355
64Tubulointerstitial nephritis (HP:0001970)2.10365802
65Acute hepatic failure (HP:0006554)2.10048017
66Increased CSF protein (HP:0002922)2.09801876
67Neonatal hypoglycemia (HP:0001998)2.08950480
68Symptomatic seizures (HP:0011145)2.06627803
69Enlarged kidneys (HP:0000105)2.05819581
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05177746
71Intrahepatic cholestasis (HP:0001406)2.04489932
72Myocardial infarction (HP:0001658)2.04086179
73Abnormality of the pleura (HP:0002103)2.03584315
74Abnormality of T cell physiology (HP:0011840)2.03453755
75Recurrent skin infections (HP:0001581)2.03121568
76Abnormality of the intrinsic pathway (HP:0010989)2.03036317
77Abnormality of the renal cortex (HP:0011035)2.02492109
78Vertigo (HP:0002321)2.01803583
79Peritonitis (HP:0002586)2.01676556
80Chest pain (HP:0100749)1.98135673
81Microcytic anemia (HP:0001935)1.96208894
82Complement deficiency (HP:0004431)1.95213739
83Hydroxyprolinuria (HP:0003080)1.93190338
84Abnormality of proline metabolism (HP:0010907)1.93190338
85Gingivitis (HP:0000230)1.92625648
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92519632
87True hermaphroditism (HP:0010459)1.92145870
88Azoospermia (HP:0000027)1.92023494
89Arterial thrombosis (HP:0004420)1.90214066
90Epistaxis (HP:0000421)1.89889159
91Osteolytic defects of the hand bones (HP:0009699)1.89490031
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.89490031
93Hepatocellular carcinoma (HP:0001402)1.89272846
94Reduced antithrombin III activity (HP:0001976)1.89153386
95Abnormality of macrophages (HP:0004311)1.87587472
96Medial flaring of the eyebrow (HP:0010747)1.87468999
97Steatorrhea (HP:0002570)1.87246533
98Glomerulonephritis (HP:0000099)1.85977857
99Chronic mucocutaneous candidiasis (HP:0002728)1.85530892
100Recurrent cutaneous fungal infections (HP:0011370)1.85530892
101Patchy hypopigmentation of hair (HP:0011365)1.84877349
102Autoimmune hemolytic anemia (HP:0001890)1.84782075
103Pustule (HP:0200039)1.84760071
104Abnormality of purine metabolism (HP:0004352)1.84588879
105Joint hemorrhage (HP:0005261)1.83532745
106Fat malabsorption (HP:0002630)1.82588860
107Proximal tubulopathy (HP:0000114)1.81323592
108Hypergammaglobulinemia (HP:0010702)1.79528311
109White forelock (HP:0002211)1.78258138
110Recurrent fungal infections (HP:0002841)1.77822613
111Recurrent bronchitis (HP:0002837)1.77628005
112Hypoproteinemia (HP:0003075)1.77575984
113Autoimmune thrombocytopenia (HP:0001973)1.75271262
114Metaphyseal dysplasia (HP:0100255)1.75264206
115Gingival bleeding (HP:0000225)1.74102512
116Recurrent pneumonia (HP:0006532)1.73428762
117Encephalitis (HP:0002383)1.73400433
118Joint swelling (HP:0001386)1.73258025
119Gonadotropin excess (HP:0000837)1.72900979
120Thrombophlebitis (HP:0004418)1.72351844
121Inflammation of the large intestine (HP:0002037)1.71913001
122Chronic diarrhea (HP:0002028)1.71602302
123Type I transferrin isoform profile (HP:0003642)1.71528716
124Urticaria (HP:0001025)1.71075372
125Portal hypertension (HP:0001409)1.70544188
126Poikilocytosis (HP:0004447)1.69717600
127Recurrent viral infections (HP:0004429)1.68501721
128Disproportionate short-trunk short stature (HP:0003521)1.68390856
129Bile duct proliferation (HP:0001408)1.68386537
130Abnormal biliary tract physiology (HP:0012439)1.68386537
131Hepatosplenomegaly (HP:0001433)1.66939058
132Abnormal spermatogenesis (HP:0008669)1.66362938
133Osteomyelitis (HP:0002754)1.66249084
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65083948
135Episodic fever (HP:0001954)1.64908129
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64551695
137Glomerulopathy (HP:0100820)1.64449204
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.64092162
139Pancreatitis (HP:0001733)1.63262325
140Increased IgM level (HP:0003496)1.62864080
141Abnormality of the hepatic vasculature (HP:0006707)1.62671398
142Mediastinal lymphadenopathy (HP:0100721)1.62606998
143Abolished electroretinogram (ERG) (HP:0000550)1.62598989
144Type 2 muscle fiber atrophy (HP:0003554)1.62399069
145Hypoglycemic seizures (HP:0002173)1.61705847
146Abnormality of nucleobase metabolism (HP:0010932)1.61581619
147Acute myeloid leukemia (HP:0004808)1.61475253
148Abnormality of the endocardium (HP:0004306)1.61043295
149Neoplasm of the liver (HP:0002896)1.60793362
150Hyperuricemia (HP:0002149)1.59170873
151Increased purine levels (HP:0004368)1.59170873
152Intestinal atresia (HP:0011100)1.57605489
153Elevated alkaline phosphatase (HP:0003155)1.57306343
154Abnormality of the common coagulation pathway (HP:0010990)1.57184512
155Lip pit (HP:0100267)1.57110151
156Hematochezia (HP:0002573)1.56824212
157Hyperglycemia (HP:0003074)1.55957763
158Xanthomatosis (HP:0000991)1.55495786
159Bell-shaped thorax (HP:0001591)1.55416822
160Vertebral compression fractures (HP:0002953)1.51559326
161Abnormal enzyme/coenzyme activity (HP:0012379)1.51298139
162Vasculitis (HP:0002633)1.51199463
163Tubulointerstitial fibrosis (HP:0005576)1.50926226
164Cerebral palsy (HP:0100021)1.49308747
165Pulmonary artery stenosis (HP:0004415)1.49096940
166Nephritis (HP:0000123)1.48452985
167Abnormality of complement system (HP:0005339)1.47970723
168Abnormality of T cell number (HP:0011839)1.47597284
169Petechiae (HP:0000967)1.47184424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K142.63557894
2NEK92.49870174
3IRAK32.45553611
4TYK22.43938789
5ZAK2.43338206
6SIK32.37648308
7IRAK42.29944881
8MAP4K22.28107762
9EPHA32.14176593
10TXK2.11310591
11NUAK12.09283819
12INSRR2.08076332
13ACVR1B1.91919933
14BCKDK1.84347761
15TRIM281.81837887
16TGFBR21.80195819
17FLT31.78466581
18BMPR1B1.72589950
19IKBKE1.70071347
20CHUK1.62656523
21TBK11.61531429
22IKBKB1.57278753
23FRK1.56365988
24TGFBR11.56257843
25TAOK31.55875927
26FES1.54001313
27MAP3K121.53889178
28PBK1.45065382
29FGFR41.44920298
30MAP4K11.44495754
31FER1.43904503
32LATS11.43772420
33AKT31.39482104
34CAMKK21.36572976
35TIE11.35839608
36RPS6KA41.34537178
37HCK1.34153222
38PIK3CG1.32645329
39BRSK21.31899735
40TEC1.28992548
41STK241.28912417
42GRK11.28141349
43JAK31.27378209
44NLK1.23832797
45KIT1.23190356
46MAP3K31.19749547
47EPHB11.17494698
48TRPM71.16780301
49MST1R1.16599835
50RIPK41.15726444
51STK31.13592654
52ERBB31.12561296
53SYK1.08593035
54GRK71.08426849
55STK38L1.06979379
56GRK61.06696159
57IRAK11.06245675
58NEK61.05817067
59ZAP701.04624564
60BTK1.01509863
61JAK11.01288515
62DYRK1B1.01067276
63PIM10.97835757
64PIK3CA0.97545907
65STK40.96636348
66MET0.92944271
67PTK2B0.91808154
68PRKCQ0.89901464
69ERN10.89260413
70TNK20.88159285
71CLK10.86664717
72LMTK20.85070668
73PAK30.84505087
74PDK20.82687238
75MAP3K50.81306431
76EIF2AK30.81265146
77FGR0.80032075
78ITK0.79877522
79YES10.79459951
80KDR0.77560783
81MAP3K10.77283251
82PASK0.76655106
83CSK0.74649468
84EIF2AK20.73963069
85OBSCN0.73289369
86PINK10.72762236
87FGFR30.71645750
88RAF10.71611306
89STK160.71027781
90CSF1R0.70194312
91MAPK70.69020091
92SIK10.68769599
93MST40.67146004
94CDK90.67101723
95BMPR20.66358095
96DYRK30.65492946
97MAP3K20.64997024
98RPS6KA50.64646469
99BRD40.62615622
100MAPK150.59522118
101HIPK20.59202370
102RPS6KA60.57532316
103LYN0.56886265
104IRAK20.56859123
105PIM20.56580983
106BCR0.55854740
107MYLK0.55737711
108SGK30.55447249
109SGK20.53825459
110CDK60.53474511
111MARK30.53240233
112ABL10.51896968
113BLK0.50500997
114KSR10.49904236
115LCK0.49685201
116STK380.48795759
117PRKAA20.48649449
118OXSR10.47293290
119MATK0.46215711
120CDK80.46198749
121MAP2K30.46101243
122PRKCE0.45704249
123IGF1R0.42126288
124MKNK10.42123277
125STK100.42100306
126EGFR0.41503456
127MELK0.40746699
128ADRBK20.40670230
129PLK20.38990560
130EIF2AK10.38543973
131PTK60.38324771
132MAPKAPK20.37622850
133RPS6KC10.37379352
134RPS6KL10.37379352
135JAK20.37237411
136EPHA20.37119458

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.11471100
2NF-kappa B signaling pathway_Homo sapiens_hsa040641.86443382
3Protein export_Homo sapiens_hsa030601.84638451
4Primary bile acid biosynthesis_Homo sapiens_hsa001201.84450232
5Retinol metabolism_Homo sapiens_hsa008301.84064662
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80935228
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78792481
8Complement and coagulation cascades_Homo sapiens_hsa046101.68254121
9Fatty acid degradation_Homo sapiens_hsa000711.68181833
10Regulation of autophagy_Homo sapiens_hsa041401.67523313
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61593360
12Type I diabetes mellitus_Homo sapiens_hsa049401.57752596
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57151805
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.56854537
15Dorso-ventral axis formation_Homo sapiens_hsa043201.53711093
16Legionellosis_Homo sapiens_hsa051341.53436551
17Peroxisome_Homo sapiens_hsa041461.51984670
18Tryptophan metabolism_Homo sapiens_hsa003801.51914453
19Circadian rhythm_Homo sapiens_hsa047101.51587509
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51083650
21Leishmaniasis_Homo sapiens_hsa051401.50615011
22Measles_Homo sapiens_hsa051621.41843542
23Asthma_Homo sapiens_hsa053101.40826848
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39917326
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.39132585
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37621555
27Sulfur metabolism_Homo sapiens_hsa009201.34681204
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33284839
29T cell receptor signaling pathway_Homo sapiens_hsa046601.32617679
30Caffeine metabolism_Homo sapiens_hsa002321.30268041
31Antigen processing and presentation_Homo sapiens_hsa046121.25703161
32Herpes simplex infection_Homo sapiens_hsa051681.25485101
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24078711
34Primary immunodeficiency_Homo sapiens_hsa053401.23641676
35Chemokine signaling pathway_Homo sapiens_hsa040621.23080665
36Folate biosynthesis_Homo sapiens_hsa007901.19344288
37Histidine metabolism_Homo sapiens_hsa003401.18503857
38Allograft rejection_Homo sapiens_hsa053301.18342286
39Malaria_Homo sapiens_hsa051441.18232145
40Influenza A_Homo sapiens_hsa051641.17981522
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.15682642
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13823184
43Fatty acid elongation_Homo sapiens_hsa000621.11799598
44Selenocompound metabolism_Homo sapiens_hsa004501.09129853
45Propanoate metabolism_Homo sapiens_hsa006401.08511799
46Toxoplasmosis_Homo sapiens_hsa051451.07081676
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07072587
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05903234
49Chemical carcinogenesis_Homo sapiens_hsa052041.05683216
50Pertussis_Homo sapiens_hsa051331.05437248
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05256108
52Steroid biosynthesis_Homo sapiens_hsa001001.01689019
53Lysosome_Homo sapiens_hsa041421.01571822
54Osteoclast differentiation_Homo sapiens_hsa043801.01053905
55ABC transporters_Homo sapiens_hsa020101.00838332
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97823897
57Fatty acid metabolism_Homo sapiens_hsa012120.97336343
58Basal transcription factors_Homo sapiens_hsa030220.97208853
59Linoleic acid metabolism_Homo sapiens_hsa005910.96699636
60FoxO signaling pathway_Homo sapiens_hsa040680.95898473
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95382708
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94215216
63Starch and sucrose metabolism_Homo sapiens_hsa005000.94036079
64Graft-versus-host disease_Homo sapiens_hsa053320.93899144
65African trypanosomiasis_Homo sapiens_hsa051430.93494785
66PPAR signaling pathway_Homo sapiens_hsa033200.93494227
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93267086
68Vitamin digestion and absorption_Homo sapiens_hsa049770.92611961
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92271156
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.91867373
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90925175
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90652210
73Platelet activation_Homo sapiens_hsa046110.90113233
74Other glycan degradation_Homo sapiens_hsa005110.89755290
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.86730376
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85054096
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84814366
78beta-Alanine metabolism_Homo sapiens_hsa004100.84462712
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.83835594
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83217547
81Butanoate metabolism_Homo sapiens_hsa006500.81559156
82Hematopoietic cell lineage_Homo sapiens_hsa046400.81516536
83Phagosome_Homo sapiens_hsa041450.80770809
84Hepatitis C_Homo sapiens_hsa051600.80278493
85TNF signaling pathway_Homo sapiens_hsa046680.79034080
86Prolactin signaling pathway_Homo sapiens_hsa049170.78760728
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76973870
88Homologous recombination_Homo sapiens_hsa034400.76338224
89Non-homologous end-joining_Homo sapiens_hsa034500.73117554
90Apoptosis_Homo sapiens_hsa042100.71600716
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70811692
92Autoimmune thyroid disease_Homo sapiens_hsa053200.69971963
93Ether lipid metabolism_Homo sapiens_hsa005650.67253945
94Sphingolipid metabolism_Homo sapiens_hsa006000.67113097
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66586664
96Arachidonic acid metabolism_Homo sapiens_hsa005900.66432402
97Nitrogen metabolism_Homo sapiens_hsa009100.66372022
98Phenylalanine metabolism_Homo sapiens_hsa003600.66146807
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65403093
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65073587
101Thyroid cancer_Homo sapiens_hsa052160.64395242
102Glycerolipid metabolism_Homo sapiens_hsa005610.64221706
103Tuberculosis_Homo sapiens_hsa051520.63393542
104RNA polymerase_Homo sapiens_hsa030200.63305876
105TGF-beta signaling pathway_Homo sapiens_hsa043500.63077736
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.62963047
107Shigellosis_Homo sapiens_hsa051310.62425424
108Notch signaling pathway_Homo sapiens_hsa043300.61333792
109Lysine degradation_Homo sapiens_hsa003100.60787842
110p53 signaling pathway_Homo sapiens_hsa041150.60785813
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60031954
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59617291
113Tyrosine metabolism_Homo sapiens_hsa003500.59390931
114Rheumatoid arthritis_Homo sapiens_hsa053230.58777846
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.57961225
116Glutathione metabolism_Homo sapiens_hsa004800.55772515
117Small cell lung cancer_Homo sapiens_hsa052220.54926741
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54569815
119Phototransduction_Homo sapiens_hsa047440.54239830
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54229922
121Hepatitis B_Homo sapiens_hsa051610.54016145
122B cell receptor signaling pathway_Homo sapiens_hsa046620.52467682
123Mismatch repair_Homo sapiens_hsa034300.50423476
124One carbon pool by folate_Homo sapiens_hsa006700.50221285
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49738782
126Base excision repair_Homo sapiens_hsa034100.48819945
127Mineral absorption_Homo sapiens_hsa049780.48499191
128Adherens junction_Homo sapiens_hsa045200.48032958
129Insulin resistance_Homo sapiens_hsa049310.47436139
130Viral myocarditis_Homo sapiens_hsa054160.46587076
131Acute myeloid leukemia_Homo sapiens_hsa052210.45765521
132HIF-1 signaling pathway_Homo sapiens_hsa040660.45627694
133Epstein-Barr virus infection_Homo sapiens_hsa051690.45005643
134RNA degradation_Homo sapiens_hsa030180.44605222
135Amoebiasis_Homo sapiens_hsa051460.42554072
136Olfactory transduction_Homo sapiens_hsa047400.40461181
137Ovarian steroidogenesis_Homo sapiens_hsa049130.39428714
138Inositol phosphate metabolism_Homo sapiens_hsa005620.38324534
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.37089447
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.36165122

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