HBQ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* oxygen transport (GO:0015671)8.34198615
2protoporphyrinogen IX metabolic process (GO:0046501)7.58348777
3* gas transport (GO:0015669)7.18545344
4neutrophil activation involved in immune response (GO:0002283)7.07688249
5protoporphyrinogen IX biosynthetic process (GO:0006782)6.36467210
6erythrocyte maturation (GO:0043249)6.30300818
7hemoglobin metabolic process (GO:0020027)6.22447119
8heme biosynthetic process (GO:0006783)5.53731886
9porphyrin-containing compound biosynthetic process (GO:0006779)5.29811812
10erythrocyte development (GO:0048821)4.90373011
11tetrapyrrole biosynthetic process (GO:0033014)4.75106307
12leukocyte migration involved in inflammatory response (GO:0002523)4.74823901
13heme metabolic process (GO:0042168)4.69105775
14porphyrin-containing compound metabolic process (GO:0006778)4.64895373
15regulation of platelet aggregation (GO:0090330)4.48879807
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.46658339
17neutrophil activation (GO:0042119)4.36494319
18myeloid cell development (GO:0061515)4.20833474
19positive regulation of granulocyte differentiation (GO:0030854)4.15089523
20protein neddylation (GO:0045116)4.09402418
21negative regulation of erythrocyte differentiation (GO:0045647)4.05939068
22granulocyte activation (GO:0036230)3.99535848
23granulocyte differentiation (GO:0030851)3.89819156
24regulation of mast cell degranulation (GO:0043304)3.80274618
25positive regulation by symbiont of host defense response (GO:0052509)3.78933678
26modulation by symbiont of host defense response (GO:0052031)3.78933678
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78933678
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78933678
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.78933678
30modulation by symbiont of host immune response (GO:0052553)3.78933678
31leukocyte degranulation (GO:0043299)3.74697277
32platelet formation (GO:0030220)3.67312432
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67029484
34megakaryocyte development (GO:0035855)3.65410591
35negative regulation of cell killing (GO:0031342)3.54681797
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54681797
37positive regulation of mast cell activation (GO:0033005)3.46694659
38regulation of mast cell activation involved in immune response (GO:0033006)3.46670316
39positive regulation of gamma-delta T cell activation (GO:0046645)3.40949931
40deoxyribose phosphate biosynthetic process (GO:0046385)3.37857715
412-deoxyribonucleotide biosynthetic process (GO:0009265)3.37857715
423-UTR-mediated mRNA stabilization (GO:0070935)3.29111123
43modulation by virus of host process (GO:0019054)3.28131442
44detection of bacterium (GO:0016045)3.22643310
45lipoxygenase pathway (GO:0019372)3.19780978
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19425258
47thrombin receptor signaling pathway (GO:0070493)3.16389941
48myeloid cell activation involved in immune response (GO:0002275)3.16278852
49autophagic vacuole fusion (GO:0000046)3.15120045
50regulation of platelet activation (GO:0010543)3.15028270
51regulation of erythrocyte differentiation (GO:0045646)3.13965233
52adenosine receptor signaling pathway (GO:0001973)3.13485088
53negative regulation of phagocytosis (GO:0050765)3.13131677
54detection of other organism (GO:0098543)3.10081272
55regulation of mast cell activation (GO:0033003)3.08299204
56positive regulation of B cell differentiation (GO:0045579)3.07894492
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06012842
58leukocyte aggregation (GO:0070486)3.04010979
59positive regulation of fibroblast migration (GO:0010763)3.03830764
60response to peptidoglycan (GO:0032494)3.00319297
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91472722
62platelet aggregation (GO:0070527)2.91106702
63respiratory burst (GO:0045730)2.90533751
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88975089
65response to host immune response (GO:0052572)2.88975089
66regulation of B cell receptor signaling pathway (GO:0050855)2.83977781
67viral protein processing (GO:0019082)2.83616729
68Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83060498
69tetrapyrrole metabolic process (GO:0033013)2.82626903
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82482138
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80666197
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80023801
73hydrogen peroxide catabolic process (GO:0042744)2.77648986
74regulation of leukocyte degranulation (GO:0043300)2.77607747
75regulation of granulocyte differentiation (GO:0030852)2.76804050
76purine-containing compound salvage (GO:0043101)2.76665967
77antigen processing and presentation of endogenous antigen (GO:0019883)2.73258320
78regulation of chromatin binding (GO:0035561)2.69978873
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68124772
80modulation by symbiont of host cellular process (GO:0044068)2.60441671
81GDP-mannose metabolic process (GO:0019673)2.60164147
82pentose metabolic process (GO:0019321)2.59367318
83polyamine biosynthetic process (GO:0006596)2.59341777
84definitive hemopoiesis (GO:0060216)2.57686113
85macrophage activation involved in immune response (GO:0002281)2.57342344
86positive regulation of mast cell degranulation (GO:0043306)2.55535333
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.55535333
88cellular response to virus (GO:0098586)2.54084189
89immunoglobulin mediated immune response (GO:0016064)2.53024107
90regulation of response to osmotic stress (GO:0047484)2.51235441
91actin filament polymerization (GO:0030041)2.50825880
92GMP metabolic process (GO:0046037)2.50625318
93negative regulation of lymphocyte mediated immunity (GO:0002707)2.48520954
94superoxide anion generation (GO:0042554)2.48453399
95organelle membrane fusion (GO:0090174)2.47841127
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47519083
97response to host (GO:0075136)2.47519083
98response to host defenses (GO:0052200)2.47519083
99microglial cell activation (GO:0001774)2.47443709
100negative regulation of interleukin-12 production (GO:0032695)2.47228960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_19941826_ChIP-Seq_K562_Human3.65883382
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37243233
3SCL_19346495_ChIP-Seq_HPC-7_Human3.35978601
4GATA1_22025678_ChIP-Seq_K562_Human3.35000284
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95796109
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.75069692
7E2F7_22180533_ChIP-Seq_HELA_Human2.73584343
8VDR_21846776_ChIP-Seq_THP-1_Human2.48503078
9TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.43749621
10GATA2_19941826_ChIP-Seq_K562_Human2.35924729
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.31677737
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27434565
13GATA1_22383799_ChIP-Seq_G1ME_Mouse2.26095219
14MYC_22102868_ChIP-Seq_BL_Human2.19628381
15MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.11763006
16RUNX1_22412390_ChIP-Seq_EML_Mouse2.07773345
17SPI1_23127762_ChIP-Seq_K562_Human2.07164665
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06842117
19NCOR1_26117541_ChIP-Seq_K562_Human2.05782759
20* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02328645
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01144780
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00758505
23SPI1_23547873_ChIP-Seq_NB4_Human2.00244140
24UTX_26944678_Chip-Seq_JUKART_Human1.96117636
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95332751
26MAF_26560356_Chip-Seq_TH1_Human1.94802771
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94476880
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88743761
29* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.87237355
30VDR_24763502_ChIP-Seq_THP-1_Human1.82252301
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79309416
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76415901
33GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73956905
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73739023
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73609546
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68488578
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66718605
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.66710203
39GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63500564
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62353336
41BCL6_27268052_Chip-Seq_Bcells_Human1.61436010
42* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57399609
43* MAF_26560356_Chip-Seq_TH2_Human1.57213546
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57054331
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.55558854
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53629568
47BCOR_27268052_Chip-Seq_Bcells_Human1.52257494
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51661181
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50920028
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48906907
51TCF7_22412390_ChIP-Seq_EML_Mouse1.48673130
52* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47451515
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.46057394
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45392931
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45053307
56P68_20966046_ChIP-Seq_HELA_Human1.37800300
57LXR_22292898_ChIP-Seq_THP-1_Human1.34630797
58KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33592324
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31805373
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.29397258
61KDM2B_26808549_Chip-Seq_DND41_Human1.29244809
62MYB_26560356_Chip-Seq_TH1_Human1.28893185
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28558854
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24752522
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24479146
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23919017
67MYB_26560356_Chip-Seq_TH2_Human1.22435892
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21580869
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.20985523
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19366989
71SPI1_20517297_ChIP-Seq_HL60_Human1.18948137
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.17342358
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.15422332
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14083792
75* CTCF_21964334_Chip-Seq_Bcells_Human1.12877328
76* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12438086
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12349039
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11741748
79RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11392610
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.11363761
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10342740
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09990352
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08945329
84FOXP3_21729870_ChIP-Seq_TREG_Human1.08815626
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08434040
86TFEB_21752829_ChIP-Seq_HELA_Human1.07649630
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07544034
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06888122
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06838425
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05179523
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04479134
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03846294
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03722199
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03333869
95PHF8_20622854_ChIP-Seq_HELA_Human1.02854868
96CIITA_25753668_ChIP-Seq_RAJI_Human1.02652729
97E2F1_20622854_ChIP-Seq_HELA_Human1.02586326
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00895958
99ETS1_20019798_ChIP-Seq_JURKAT_Human0.99764964
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99063919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.27894733
2MP0003656_abnormal_erythrocyte_physiolo4.68800079
3MP0004147_increased_porphyrin_level4.41159942
4MP0005083_abnormal_biliary_tract4.15789145
5MP0003724_increased_susceptibility_to3.29211752
6MP0002132_abnormal_respiratory_system3.25890260
7MP0005397_hematopoietic_system_phenotyp3.14707683
8MP0001545_abnormal_hematopoietic_system3.14707683
9MP0003303_peritoneal_inflammation3.08505780
10MP0003436_decreased_susceptibility_to2.78424657
11MP0001835_abnormal_antigen_presentation2.13682571
12MP0002398_abnormal_bone_marrow2.12764921
13MP0008004_abnormal_stomach_pH2.02279514
14MP0008260_abnormal_autophagy2.01960276
15MP0002419_abnormal_innate_immunity1.99859627
16MP0003806_abnormal_nucleotide_metabolis1.97982794
17MP0005025_abnormal_response_to1.96726437
18MP0000465_gastrointestinal_hemorrhage1.89900451
19MP0009278_abnormal_bone_marrow1.88613187
20MP0005000_abnormal_immune_tolerance1.80214096
21MP0002420_abnormal_adaptive_immunity1.75545391
22MP0009333_abnormal_splenocyte_physiolog1.73696520
23MP0002722_abnormal_immune_system1.73633370
24MP0001819_abnormal_immune_cell1.73459796
25MP0005671_abnormal_response_to1.70090333
26MP0002723_abnormal_immune_serum1.68284036
27MP0000689_abnormal_spleen_morphology1.67744810
28MP0001800_abnormal_humoral_immune1.65725181
29MP0002429_abnormal_blood_cell1.63590592
30MP0005387_immune_system_phenotype1.61392396
31MP0001790_abnormal_immune_system1.61392396
32MP0006036_abnormal_mitochondrial_physio1.60654633
33MP0000685_abnormal_immune_system1.59941751
34MP0003186_abnormal_redox_activity1.55929370
35MP0009785_altered_susceptibility_to1.53620249
36MP0002452_abnormal_antigen_presenting1.51741913
37MP0002405_respiratory_system_inflammati1.47583610
38MP0000716_abnormal_immune_system1.46194765
39MP0005377_hearing/vestibular/ear_phenot1.45800849
40MP0003878_abnormal_ear_physiology1.45800849
41MP0002148_abnormal_hypersensitivity_rea1.44014550
42MP0006035_abnormal_mitochondrial_morpho1.41856284
43MP0000703_abnormal_thymus_morphology1.41715125
44MP0000343_altered_response_to1.39920497
45MP0010155_abnormal_intestine_physiology1.36556449
46MP0003866_abnormal_defecation1.35885064
47MP0009764_decreased_sensitivity_to1.34966777
48MP0002396_abnormal_hematopoietic_system1.30783856
49MP0003300_gastrointestinal_ulcer1.24551264
50MP0005451_abnormal_body_composition1.24014380
51MP0000490_abnormal_crypts_of1.22618971
52MP0003191_abnormal_cellular_cholesterol1.22531755
53MP0000015_abnormal_ear_pigmentation1.22338663
54MP0004947_skin_inflammation1.20896172
55MP0005636_abnormal_mineral_homeostasis1.19061179
56MP0003763_abnormal_thymus_physiology1.18587172
57MP0008995_early_reproductive_senescence1.18270401
58MP0001533_abnormal_skeleton_physiology1.17019832
59MP0001845_abnormal_inflammatory_respons1.15077773
60MP0005084_abnormal_gallbladder_morpholo1.14089463
61MP0006082_CNS_inflammation1.12588487
62MP0002653_abnormal_ependyma_morphology1.12350859
63MP0003111_abnormal_nucleus_morphology1.10892418
64MP0003172_abnormal_lysosome_physiology1.07224584
65MP0009765_abnormal_xenobiotic_induced1.02245631
66MP0009763_increased_sensitivity_to1.01855789
67MP0005058_abnormal_lysosome_morphology1.01651410
68MP0001851_eye_inflammation0.97937516
69MP0001663_abnormal_digestive_system0.97633491
70MP0000313_abnormal_cell_death0.95548339
71MP0008469_abnormal_protein_level0.93332554
72MP0005075_abnormal_melanosome_morpholog0.86647217
73MP0003879_abnormal_hair_cell0.86108214
74MP0002019_abnormal_tumor_incidence0.85945597
75MP0000858_altered_metastatic_potential0.84407124
76MP0004510_myositis0.84296934
77MP0004130_abnormal_muscle_cell0.82960713
78MP0008874_decreased_physiological_sensi0.82810733
79MP0009931_abnormal_skin_appearance0.80254763
80MP0008058_abnormal_DNA_repair0.80088643
81MP0008872_abnormal_physiological_respon0.79167851
82MP0003828_pulmonary_edema0.77759791
83MP0005410_abnormal_fertilization0.77260407
84MP0004808_abnormal_hematopoietic_stem0.77022364
85MP0000358_abnormal_cell_content/0.74651624
86MP0003786_premature_aging0.73125935
87MP0004957_abnormal_blastocyst_morpholog0.72144896
88MP0003566_abnormal_cell_adhesion0.71840980
89MP0005310_abnormal_salivary_gland0.71170449
90MP0004381_abnormal_hair_follicle0.69236700
91MP0001986_abnormal_taste_sensitivity0.67108107
92MP0003638_abnormal_response/metabolism_0.65759943
93MP0009642_abnormal_blood_homeostasis0.63934975
94MP0001873_stomach_inflammation0.63773340
95MP0000598_abnormal_liver_morphology0.62393410
96MP0005174_abnormal_tail_pigmentation0.61840521
97MP0001905_abnormal_dopamine_level0.60889333
98MP0003075_altered_response_to0.60757219
99MP0005319_abnormal_enzyme/_coenzyme0.60649234
100MP0003183_abnormal_peptide_metabolism0.60546684

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)8.92214568
2Prolonged bleeding time (HP:0003010)7.55631116
3Petechiae (HP:0000967)6.36470507
4Abnormal hemoglobin (HP:0011902)5.95537390
5Hypochromic anemia (HP:0001931)5.62207134
6Poikilocytosis (HP:0004447)5.60342825
7Microcytic anemia (HP:0001935)5.26731292
8Abnormal platelet volume (HP:0011876)4.95563008
9Epistaxis (HP:0000421)4.70560681
10Purpura (HP:0000979)4.65626851
11Menorrhagia (HP:0000132)4.53582866
12Reticulocytosis (HP:0001923)4.51330254
13Increased mean platelet volume (HP:0011877)4.48229218
14Polycythemia (HP:0001901)4.48082653
15Acanthocytosis (HP:0001927)4.38537793
16Cholelithiasis (HP:0001081)3.75856550
17Eczematoid dermatitis (HP:0000976)3.75577556
18Chronic obstructive pulmonary disease (HP:0006510)3.75276529
19Obstructive lung disease (HP:0006536)3.75276529
20Gingival bleeding (HP:0000225)3.70144131
21Abnormal platelet function (HP:0011869)3.65693818
22Impaired platelet aggregation (HP:0003540)3.65693818
23Abnormality of macrophages (HP:0004311)3.62685435
24Stomatitis (HP:0010280)3.56328002
25Recurrent abscess formation (HP:0002722)3.52813779
26Abnormality of iron homeostasis (HP:0011031)3.49388931
27Paralysis (HP:0003470)3.45408042
28Abnormal gallbladder physiology (HP:0012438)3.38480273
29Cholecystitis (HP:0001082)3.38480273
30Abnormal gallbladder morphology (HP:0012437)3.33101277
31Increased serum ferritin (HP:0003281)3.29650305
32Recurrent bacterial skin infections (HP:0005406)3.27226791
33Abnormality of reticulocytes (HP:0004312)2.98834592
34Toxemia of pregnancy (HP:0100603)2.98093366
35Abnormality of transition element cation homeostasis (HP:0011030)2.97782374
36Spontaneous hematomas (HP:0007420)2.92380067
37Urticaria (HP:0001025)2.79576629
38Pallor (HP:0000980)2.71372932
39Increased IgM level (HP:0003496)2.69515844
40Encephalitis (HP:0002383)2.69090553
41Episodic fever (HP:0001954)2.65206638
42Ileus (HP:0002595)2.63628885
43Myositis (HP:0100614)2.56981046
44Hypertensive crisis (HP:0100735)2.52901682
45Gastrointestinal infarctions (HP:0005244)2.52899960
46Abnormality of the gallbladder (HP:0005264)2.45711785
47Hyperthyroidism (HP:0000836)2.42517373
48Hepatosplenomegaly (HP:0001433)2.42076954
49Hyperbilirubinemia (HP:0002904)2.39663237
50Recurrent gram-negative bacterial infections (HP:0005420)2.35298851
51Elevated erythrocyte sedimentation rate (HP:0003565)2.35011636
52Hyperlipoproteinemia (HP:0010980)2.34324011
53Bruising susceptibility (HP:0000978)2.25379443
54Anorexia (HP:0002039)2.24781802
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.22837618
56Cutaneous photosensitivity (HP:0000992)2.16456707
57Orchitis (HP:0100796)2.16090004
58Abnormal number of erythroid precursors (HP:0012131)2.15740497
59Pustule (HP:0200039)2.12764721
60Recurrent fungal infections (HP:0002841)2.11559060
61Inflammation of the large intestine (HP:0002037)2.09887826
62Gastrointestinal inflammation (HP:0004386)2.09136220
63Nausea (HP:0002018)2.07616748
64Meningitis (HP:0001287)2.05964173
65Increased IgE level (HP:0003212)2.03499309
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03473584
67Ventricular fibrillation (HP:0001663)2.00585548
68Abnormality of the heme biosynthetic pathway (HP:0010472)10.7502876
69Cellulitis (HP:0100658)1.99277587
70Panhypogammaglobulinemia (HP:0003139)1.94894913
71Abnormality of lateral ventricle (HP:0030047)1.92465619
72Granulocytopenia (HP:0001913)1.91326577
73Retrobulbar optic neuritis (HP:0100654)1.89770975
74Optic neuritis (HP:0100653)1.89770975
75Recurrent skin infections (HP:0001581)1.85932233
76Truncus arteriosus (HP:0001660)1.85877530
77Gastrointestinal dysmotility (HP:0002579)1.84569229
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84509086
79Dysautonomia (HP:0002459)1.81763130
80Abnormality of cells of the erythroid lineage (HP:0012130)1.77323860
81Aplastic anemia (HP:0001915)1.76735566
82Mediastinal lymphadenopathy (HP:0100721)1.76192572
83Osteomyelitis (HP:0002754)1.75920254
84Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74097317
85Abnormality of T cell physiology (HP:0011840)1.73884830
86Severe visual impairment (HP:0001141)1.72499316
87Hypertriglyceridemia (HP:0002155)1.71169859
88Gingivitis (HP:0000230)1.70456280
89Short middle phalanx of the 5th finger (HP:0004220)1.70322006
90Leukocytosis (HP:0001974)1.69422424
91Abnormal pupillary function (HP:0007686)1.69304578
92Chest pain (HP:0100749)1.69239628
93Splenomegaly (HP:0001744)1.67194693
94Hepatocellular carcinoma (HP:0001402)1.63335654
953-Methylglutaconic aciduria (HP:0003535)1.62668875
96Seborrheic dermatitis (HP:0001051)1.61541981
97Keratoconjunctivitis sicca (HP:0001097)1.58894150
98Increased density of long bones (HP:0006392)1.58576797
99Vasculitis (HP:0002633)1.57694270
100Tinnitus (HP:0000360)1.55423234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.07402209
2EIF2AK14.80136408
3MAP2K33.62780268
4GRK63.29739469
5MAP3K113.27643608
6TAOK12.89168582
7TNK22.79680272
8BMX2.57861518
9MAP4K12.47684227
10TAOK22.44143774
11BTK2.26873490
12IRAK42.16198739
13ERN12.10237690
14TESK21.99837061
15MAP3K31.98331606
16BLK1.96753767
17SYK1.72846490
18ZAP701.67862292
19FES1.58746729
20HCK1.53562227
21MST41.48088889
22PTK2B1.43360502
23TEC1.41083466
24MAP3K11.35701252
25FGR1.28831945
26PRPF4B1.28349044
27MARK31.24047428
28LYN1.21851698
29CSK1.21053649
30TAOK31.16831983
31PIM11.16489383
32TYK21.05455296
33PIM21.02817068
34CLK11.01540437
35MAP3K50.98898539
36GRK50.98239053
37IKBKB0.96349209
38SIK30.96280684
39KSR20.95046641
40EPHB10.89641624
41JAK20.89491078
42MATK0.89095683
43SMG10.88923879
44RAF10.88542671
45BCKDK0.88095132
46JAK30.85155287
47VRK20.83799343
48STK40.80396581
49DYRK30.79153658
50STK160.78704044
51BMPR20.75904314
52MAP2K40.73020060
53TXK0.70381524
54PAK10.68908571
55MAP3K80.68842726
56ILK0.67274659
57LCK0.66555151
58HIPK20.65806465
59PRKD20.64951332
60TLK10.64755463
61CSF1R0.64427679
62MAPK120.63495242
63MARK20.62321383
64DYRK20.61829103
65KDR0.59791957
66RPS6KA50.59165356
67TBK10.58231318
68DYRK1B0.57680856
69IKBKE0.55745865
70PLK40.55721855
71ITK0.55248737
72PDPK10.54566103
73ZAK0.49679722
74PDK10.49460809
75SIK20.48129552
76PTK60.45444918
77LRRK20.44164354
78MYLK0.43518330
79YES10.39554376
80IRAK30.39538942
81BRAF0.37966694
82SIK10.37956607
83RET0.37040971
84AURKA0.36633866
85CCNB10.33706572
86DAPK10.33373768
87FYN0.33128020
88PLK30.32859056
89DAPK20.32385364
90DAPK30.32173328
91MAPKAPK20.31653740
92PIK3CG0.31101715
93TRIB30.30957909
94IRAK10.30823879
95NME20.28773696
96PRKD10.27686146
97PRKCQ0.26899916
98MAP3K60.24845339
99ADRBK10.24659200
100PRKCD0.24540843

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.23988975
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.02136181
3Platelet activation_Homo sapiens_hsa046112.83839178
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.61755587
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.29684356
6Osteoclast differentiation_Homo sapiens_hsa043802.26992336
7Hematopoietic cell lineage_Homo sapiens_hsa046402.15614000
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11019559
9Acute myeloid leukemia_Homo sapiens_hsa052212.09072208
10Collecting duct acid secretion_Homo sapiens_hsa049662.01194954
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94571816
12Primary immunodeficiency_Homo sapiens_hsa053401.93020103
13B cell receptor signaling pathway_Homo sapiens_hsa046621.92150217
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86641198
15Sulfur relay system_Homo sapiens_hsa041221.85317405
16Mismatch repair_Homo sapiens_hsa034301.76438547
17Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.73826999
18African trypanosomiasis_Homo sapiens_hsa051431.70721988
19Leishmaniasis_Homo sapiens_hsa051401.68756761
20Chemokine signaling pathway_Homo sapiens_hsa040621.68271402
21DNA replication_Homo sapiens_hsa030301.59778565
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56908241
23Non-small cell lung cancer_Homo sapiens_hsa052231.55690501
24Pancreatic cancer_Homo sapiens_hsa052121.54578859
25Staphylococcus aureus infection_Homo sapiens_hsa051501.37533663
26Shigellosis_Homo sapiens_hsa051311.36397797
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34688081
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.34098840
29Parkinsons disease_Homo sapiens_hsa050121.33038064
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32045063
31Tuberculosis_Homo sapiens_hsa051521.26257867
32Nitrogen metabolism_Homo sapiens_hsa009101.24672080
33Regulation of autophagy_Homo sapiens_hsa041401.23529011
34Base excision repair_Homo sapiens_hsa034101.23438812
35Herpes simplex infection_Homo sapiens_hsa051681.21598468
36Endocytosis_Homo sapiens_hsa041441.15520292
37Chronic myeloid leukemia_Homo sapiens_hsa052201.14529825
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13307133
39Measles_Homo sapiens_hsa051621.11220310
40Oxidative phosphorylation_Homo sapiens_hsa001901.11194577
41Pentose phosphate pathway_Homo sapiens_hsa000301.08931330
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08789286
43Phagosome_Homo sapiens_hsa041451.05196559
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01279230
45Apoptosis_Homo sapiens_hsa042101.00756390
46Pyrimidine metabolism_Homo sapiens_hsa002400.97838565
47T cell receptor signaling pathway_Homo sapiens_hsa046600.97778544
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95649800
49Homologous recombination_Homo sapiens_hsa034400.93885485
50Viral carcinogenesis_Homo sapiens_hsa052030.92800798
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91533606
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89610061
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.87850611
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85419812
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.82420405
56Hepatitis B_Homo sapiens_hsa051610.78562707
57Graft-versus-host disease_Homo sapiens_hsa053320.76875801
58VEGF signaling pathway_Homo sapiens_hsa043700.76698403
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.75545960
60One carbon pool by folate_Homo sapiens_hsa006700.73064358
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72736026
62Arachidonic acid metabolism_Homo sapiens_hsa005900.67891294
63Endometrial cancer_Homo sapiens_hsa052130.66516195
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65866163
65Alcoholism_Homo sapiens_hsa050340.65249571
66Systemic lupus erythematosus_Homo sapiens_hsa053220.63451066
67Epstein-Barr virus infection_Homo sapiens_hsa051690.63242998
68Allograft rejection_Homo sapiens_hsa053300.63151535
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63089067
70Thyroid cancer_Homo sapiens_hsa052160.62956500
71Influenza A_Homo sapiens_hsa051640.62603398
72Glutathione metabolism_Homo sapiens_hsa004800.61346733
73Renal cell carcinoma_Homo sapiens_hsa052110.60629988
74Toxoplasmosis_Homo sapiens_hsa051450.60582137
75Legionellosis_Homo sapiens_hsa051340.59221501
76Bladder cancer_Homo sapiens_hsa052190.58198159
77Cell cycle_Homo sapiens_hsa041100.56460150
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.56104166
79Salmonella infection_Homo sapiens_hsa051320.54801189
80Autoimmune thyroid disease_Homo sapiens_hsa053200.54320768
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53986033
82Proteasome_Homo sapiens_hsa030500.53908978
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53325549
84Purine metabolism_Homo sapiens_hsa002300.52948021
85Hepatitis C_Homo sapiens_hsa051600.52653538
86Huntingtons disease_Homo sapiens_hsa050160.52531189
87Choline metabolism in cancer_Homo sapiens_hsa052310.52163642
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52137514
89Fanconi anemia pathway_Homo sapiens_hsa034600.51101302
90Synaptic vesicle cycle_Homo sapiens_hsa047210.51045605
91Olfactory transduction_Homo sapiens_hsa047400.48894522
92Fructose and mannose metabolism_Homo sapiens_hsa000510.45829586
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44039870
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41193662
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.39352235
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37379664
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.36634578
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35881467
99FoxO signaling pathway_Homo sapiens_hsa040680.35302246
100Nucleotide excision repair_Homo sapiens_hsa034200.35281178

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