HBS1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.72648167
2ribosome assembly (GO:0042255)4.14762488
3DNA ligation (GO:0006266)4.11602651
4DNA double-strand break processing (GO:0000729)4.10615458
5CENP-A containing nucleosome assembly (GO:0034080)4.09437404
6serine family amino acid biosynthetic process (GO:0009070)4.07207898
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02722202
8L-phenylalanine catabolic process (GO:0006559)4.02722202
9chromatin remodeling at centromere (GO:0031055)3.94612333
10COPI coating of Golgi vesicle (GO:0048205)3.93412161
11Golgi transport vesicle coating (GO:0048200)3.93412161
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91137475
13L-phenylalanine metabolic process (GO:0006558)3.91137475
14proteasome assembly (GO:0043248)3.90353390
15regulation of DNA endoreduplication (GO:0032875)3.84696761
16glycine metabolic process (GO:0006544)3.81088519
17non-recombinational repair (GO:0000726)3.78798046
18double-strand break repair via nonhomologous end joining (GO:0006303)3.78798046
19L-serine metabolic process (GO:0006563)3.77716645
20lysine metabolic process (GO:0006553)3.74663325
21lysine catabolic process (GO:0006554)3.74663325
22IMP biosynthetic process (GO:0006188)3.71804272
23tetrahydrofolate metabolic process (GO:0046653)3.67938114
24cysteine metabolic process (GO:0006534)3.67806711
25nucleobase biosynthetic process (GO:0046112)3.64429660
26establishment of integrated proviral latency (GO:0075713)3.63334726
27glyoxylate metabolic process (GO:0046487)3.61235544
28nuclear pore organization (GO:0006999)3.60293224
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.60180977
30DNA topological change (GO:0006265)3.58241921
31histone exchange (GO:0043486)3.57594887
32regulation of centriole replication (GO:0046599)3.56014847
33DNA replication checkpoint (GO:0000076)3.53669773
34DNA strand elongation involved in DNA replication (GO:0006271)3.52382263
35spindle checkpoint (GO:0031577)3.50700794
36purine nucleobase biosynthetic process (GO:0009113)3.48074402
37regulation of translational fidelity (GO:0006450)3.45937348
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.43547211
39serine family amino acid metabolic process (GO:0009069)3.41909700
40regulation of mitotic spindle checkpoint (GO:1903504)3.41797617
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41797617
42one-carbon metabolic process (GO:0006730)3.41168248
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40446699
44alpha-linolenic acid metabolic process (GO:0036109)3.39944002
45nuclear pore complex assembly (GO:0051292)3.39840665
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.39752361
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39752361
48mitotic spindle checkpoint (GO:0071174)3.38890874
49DNA strand elongation (GO:0022616)3.32054922
50DNA unwinding involved in DNA replication (GO:0006268)3.29506239
51IMP metabolic process (GO:0046040)3.29297249
52metaphase plate congression (GO:0051310)3.28619844
53telomere maintenance via semi-conservative replication (GO:0032201)3.28455002
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26880416
55replication fork processing (GO:0031297)3.25700527
56negative regulation of chromosome segregation (GO:0051985)3.24785454
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23733318
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23733318
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23733318
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.23733318
61negative regulation of sister chromatid segregation (GO:0033046)3.23733318
62tricarboxylic acid cycle (GO:0006099)3.23472246
63kinetochore organization (GO:0051383)3.22548364
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22334205
65oxaloacetate metabolic process (GO:0006107)3.22071437
66mitotic nuclear envelope disassembly (GO:0007077)3.20926133
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18291391
68maturation of 5.8S rRNA (GO:0000460)3.17049312
69spindle assembly checkpoint (GO:0071173)3.16677093
70aspartate family amino acid catabolic process (GO:0009068)3.16348238
71mitotic recombination (GO:0006312)3.16094449
72DNA replication-independent nucleosome organization (GO:0034724)3.15964825
73DNA replication-independent nucleosome assembly (GO:0006336)3.15964825
74mitotic spindle assembly checkpoint (GO:0007094)3.15329687
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14679125
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14679125
77pteridine-containing compound biosynthetic process (GO:0042559)3.14093572
78aromatic amino acid family catabolic process (GO:0009074)3.12733636
79regulation of sister chromatid segregation (GO:0033045)3.11284779
80regulation of mitotic sister chromatid separation (GO:0010965)3.11284779
81regulation of mitotic sister chromatid segregation (GO:0033047)3.11284779
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.10419060
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09842057
84negative regulation of fibrinolysis (GO:0051918)3.09302668
85DNA replication-dependent nucleosome organization (GO:0034723)3.09108197
86DNA replication-dependent nucleosome assembly (GO:0006335)3.09108197
87attachment of spindle microtubules to kinetochore (GO:0008608)3.08098301
88telomere maintenance via recombination (GO:0000722)3.07682278
89regulation of chromosome segregation (GO:0051983)3.06946447
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06195137
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06195137
92isotype switching (GO:0045190)3.06195137
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05812330
94protein localization to kinetochore (GO:0034501)3.02335446
95nuclear envelope disassembly (GO:0051081)3.00295672
96membrane disassembly (GO:0030397)3.00295672
97homocysteine metabolic process (GO:0050667)3.00290043
98proline biosynthetic process (GO:0006561)2.98246669
99serine family amino acid catabolic process (GO:0009071)2.98118086
100cullin deneddylation (GO:0010388)2.97251473
101tRNA aminoacylation for protein translation (GO:0006418)2.96218667
102chaperone-mediated protein complex assembly (GO:0051131)2.92159441
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91856769
104establishment of chromosome localization (GO:0051303)2.91085692
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90658405
106misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.89198544
107tRNA aminoacylation (GO:0043039)2.88490028
108amino acid activation (GO:0043038)2.88490028
109negative regulation of ligase activity (GO:0051352)2.87768329
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87768329
111organelle disassembly (GO:1903008)2.87046194
112intestinal cholesterol absorption (GO:0030299)2.86997299
113urea cycle (GO:0000050)2.86365274
114urea metabolic process (GO:0019627)2.86365274
115folic acid-containing compound metabolic process (GO:0006760)2.86327799
116DNA catabolic process, exonucleolytic (GO:0000738)2.84823158
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84183109
118pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.83412942
119UMP metabolic process (GO:0046049)2.83412942
120pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.83412942
121UMP biosynthetic process (GO:0006222)2.83412942
122sulfur amino acid catabolic process (GO:0000098)2.83135543
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82451571
124mitochondrial RNA metabolic process (GO:0000959)2.82137966
125mitotic chromosome condensation (GO:0007076)2.81979769
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81038280
127regulation of sister chromatid cohesion (GO:0007063)2.80368726
128COPII vesicle coating (GO:0048208)2.80297715
129regulation of centrosome cycle (GO:0046605)2.80147328
1302-oxoglutarate metabolic process (GO:0006103)2.79609109
131protein K6-linked ubiquitination (GO:0085020)2.79387146
132regulation of acyl-CoA biosynthetic process (GO:0050812)2.78753376
133kinetochore assembly (GO:0051382)2.78151549
134formation of translation preinitiation complex (GO:0001731)2.77180155
135monoubiquitinated protein deubiquitination (GO:0035520)2.76833785
136mitotic G2/M transition checkpoint (GO:0044818)2.76040086
137rRNA catabolic process (GO:0016075)2.75958057
138alpha-amino acid biosynthetic process (GO:1901607)2.74675255
139postreplication repair (GO:0006301)2.71187839
140kynurenine metabolic process (GO:0070189)2.69765105
141valine metabolic process (GO:0006573)2.68659382
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68061038
143fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67076665
144bile acid biosynthetic process (GO:0006699)2.66057869
145pore complex assembly (GO:0046931)2.66003438
146DNA geometric change (GO:0032392)2.65652979
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65587706
148sister chromatid segregation (GO:0000819)2.64875384
149ethanol oxidation (GO:0006069)2.64795866
150alpha-amino acid catabolic process (GO:1901606)2.64501218
151DNA duplex unwinding (GO:0032508)2.64466853
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.64144595
153binding of sperm to zona pellucida (GO:0007339)2.63267576
154mitotic sister chromatid segregation (GO:0000070)2.62189520
155negative regulation of fatty acid biosynthetic process (GO:0045717)2.59411676
156triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.59399743
157branched-chain amino acid catabolic process (GO:0009083)2.58127460
158dicarboxylic acid biosynthetic process (GO:0043650)2.56738402
159aspartate family amino acid metabolic process (GO:0009066)2.56547805
160mitotic metaphase plate congression (GO:0007080)2.55346877
161nitrogen cycle metabolic process (GO:0071941)2.52603340
162tyrosine metabolic process (GO:0006570)2.52364134
1634-hydroxyproline metabolic process (GO:0019471)2.51243735
164protein localization to chromosome, centromeric region (GO:0071459)2.49340931
165tricarboxylic acid metabolic process (GO:0072350)2.48720539
166sulfur amino acid biosynthetic process (GO:0000097)2.48251858
167tryptophan metabolic process (GO:0006568)2.47324871
168mitotic sister chromatid cohesion (GO:0007064)2.47136997
169regulation of fibrinolysis (GO:0051917)2.45557983
170protein deneddylation (GO:0000338)2.45357602
171pteridine-containing compound metabolic process (GO:0042558)2.45284138
172folic acid metabolic process (GO:0046655)2.43409572
173nucleoside salvage (GO:0043174)2.43232115
174coenzyme catabolic process (GO:0009109)2.43185861
175aspartate family amino acid biosynthetic process (GO:0009067)2.42157317
176regulation of gene silencing by miRNA (GO:0060964)2.41966783
177regulation of gene silencing by RNA (GO:0060966)2.41966783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87123712
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.91010694
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.30820692
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22151440
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05267665
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.00849412
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78117389
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75390470
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64802109
10* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50151019
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45942775
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38359635
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37841601
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36722954
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.35661245
16* RXR_22158963_ChIP-Seq_LIVER_Mouse2.31839458
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30949976
18AR_21909140_ChIP-Seq_LNCAP_Human2.30127855
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30125301
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29431751
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27276577
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26543324
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22232340
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.21347588
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.17904882
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13887453
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10593065
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06761384
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04589687
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03899287
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02671534
32FUS_26573619_Chip-Seq_HEK293_Human1.94902368
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.92782925
34* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91091916
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91068351
36EWS_26573619_Chip-Seq_HEK293_Human1.88527912
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87679209
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84542316
39XRN2_22483619_ChIP-Seq_HELA_Human1.81490663
40IGF1R_20145208_ChIP-Seq_DFB_Human1.78683254
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77677652
42DCP1A_22483619_ChIP-Seq_HELA_Human1.77586535
43FOXP3_21729870_ChIP-Seq_TREG_Human1.72257796
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70439422
45* GABP_19822575_ChIP-Seq_HepG2_Human1.68512488
46* VDR_23849224_ChIP-Seq_CD4+_Human1.67650891
47VDR_22108803_ChIP-Seq_LS180_Human1.65648711
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65313379
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.65141131
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63645482
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61383039
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.58979614
53ZNF274_21170338_ChIP-Seq_K562_Hela1.57903772
54MYC_18940864_ChIP-ChIP_HL60_Human1.55109945
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54757843
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52566798
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52491991
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51797989
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49861549
60KDM5A_27292631_Chip-Seq_BREAST_Human1.48271236
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.47940606
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45657275
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42186613
64ELK1_19687146_ChIP-ChIP_HELA_Human1.41609437
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36432138
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36376179
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35598738
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35477556
69* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33838739
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.33387773
71TAF15_26573619_Chip-Seq_HEK293_Human1.32525289
72* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32396232
73CLOCK_20551151_ChIP-Seq_293T_Human1.32099324
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29690192
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.29496474
76MYC_22102868_ChIP-Seq_BL_Human1.28845717
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26893448
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26153293
79CIITA_25753668_ChIP-Seq_RAJI_Human1.23450373
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22707562
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21947186
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20886003
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20635692
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19937679
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19481159
86* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16943365
87* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16686148
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.15763068
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15382066
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13394887
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13299929
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13218780
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11379544
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10679612
95TFEB_21752829_ChIP-Seq_HELA_Human1.10523420
96P300_19829295_ChIP-Seq_ESCs_Human1.09212616
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07460472
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06584161
99* TTF2_22483619_ChIP-Seq_HELA_Human1.06127674
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06003134
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.05675288
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03544179
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02920317
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02728076
105* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02249072
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98783498
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98779492
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96419761
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95602885
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95283181
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93959270
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.93057226
113GBX2_23144817_ChIP-Seq_PC3_Human0.91176233
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90968893
115* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90830394
116* CBP_20019798_ChIP-Seq_JUKART_Human0.90830394
117CHD1_26751641_Chip-Seq_LNCaP_Human0.90751929
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89894956
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89866997
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89843745
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.89141026
122* SOX17_20123909_ChIP-Seq_XEN_Mouse0.88704351
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86806958
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86135946
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85838443
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.85636799
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84361724
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83614964
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.83381536
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83287071
131ER_23166858_ChIP-Seq_MCF-7_Human0.83185391
132GATA1_22025678_ChIP-Seq_K562_Human0.81399576
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80933447
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.80081536
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79656468
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.79359152
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78863605
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.78681304
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78392270
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77799106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.84330505
2MP0002139_abnormal_hepatobiliary_system4.79183691
3MP0005360_urolithiasis3.91006149
4MP0005365_abnormal_bile_salt3.88131226
5MP0005085_abnormal_gallbladder_physiolo3.64920204
6MP0000372_irregular_coat_pigmentation2.79539470
7MP0004147_increased_porphyrin_level2.79138048
8MP0010094_abnormal_chromosome_stability2.62454748
9MP0003252_abnormal_bile_duct2.61739037
10MP0003705_abnormal_hypodermis_morpholog2.56941857
11MP0004957_abnormal_blastocyst_morpholog2.44948997
12MP0003693_abnormal_embryo_hatching2.38853701
13MP0000569_abnormal_digit_pigmentation2.22794218
14MP0001666_abnormal_nutrient_absorption2.21776803
15MP0010352_gastrointestinal_tract_polyps2.16448795
16MP0005083_abnormal_biliary_tract2.14886369
17MP0008875_abnormal_xenobiotic_pharmacok2.14561529
18MP0003077_abnormal_cell_cycle2.12096431
19MP0003111_abnormal_nucleus_morphology2.08775813
20MP0003786_premature_aging2.04221605
21MP0009697_abnormal_copulation1.93742587
22MP0008877_abnormal_DNA_methylation1.91025050
23MP0001730_embryonic_growth_arrest1.78669282
24MP0005220_abnormal_exocrine_pancreas1.75743926
25MP0003123_paternal_imprinting1.75562069
26MP0010329_abnormal_lipoprotein_level1.74814261
27MP0006054_spinal_hemorrhage1.67927990
28MP0008058_abnormal_DNA_repair1.64081796
29MP0004215_abnormal_myocardial_fiber1.61269740
30MP0001529_abnormal_vocalization1.60430471
31MP0008007_abnormal_cellular_replicative1.60275084
32MP0004145_abnormal_muscle_electrophysio1.58127334
33MP0003950_abnormal_plasma_membrane1.57502556
34MP0003656_abnormal_erythrocyte_physiolo1.57440931
35MP0002102_abnormal_ear_morphology1.56105668
36MP0005332_abnormal_amino_acid1.55287471
37MP0003890_abnormal_embryonic-extraembry1.55252245
38MP0003646_muscle_fatigue1.55237049
39MP0005408_hypopigmentation1.50730378
40MP0002653_abnormal_ependyma_morphology1.48623350
41MP0002938_white_spotting1.46333626
42MP0000609_abnormal_liver_physiology1.45913277
43MP0002269_muscular_atrophy1.42378880
44MP0006036_abnormal_mitochondrial_physio1.41462336
45MP0003941_abnormal_skin_development1.39055516
46MP0008057_abnormal_DNA_replication1.36322738
47MP0009672_abnormal_birth_weight1.34209234
48MP0002877_abnormal_melanocyte_morpholog1.33925079
49MP0004197_abnormal_fetal_growth/weight/1.32526143
50MP0009053_abnormal_anal_canal1.30404528
51MP0004264_abnormal_extraembryonic_tissu1.27326384
52MP0005319_abnormal_enzyme/_coenzyme1.27084499
53MP0005171_absent_coat_pigmentation1.26521717
54MP0010307_abnormal_tumor_latency1.26063943
55MP0001764_abnormal_homeostasis1.25924877
56MP0001697_abnormal_embryo_size1.24780506
57MP0000598_abnormal_liver_morphology1.23960567
58MP0000350_abnormal_cell_proliferation1.23751814
59MP0004233_abnormal_muscle_weight1.23435218
60MP0008932_abnormal_embryonic_tissue1.23334369
61MP0001661_extended_life_span1.23189238
62MP0005075_abnormal_melanosome_morpholog1.23083589
63MP0001672_abnormal_embryogenesis/_devel1.21549015
64MP0005380_embryogenesis_phenotype1.21549015
65MP0002080_prenatal_lethality1.19765628
66MP0002088_abnormal_embryonic_growth/wei1.19216611
67MP0003984_embryonic_growth_retardation1.19180278
68MP0005187_abnormal_penis_morphology1.17813524
69MP0003937_abnormal_limbs/digits/tail_de1.16885200
70MP0003186_abnormal_redox_activity1.16757211
71MP0002138_abnormal_hepatobiliary_system1.16491211
72MP0003868_abnormal_feces_composition1.16201240
73MP0009840_abnormal_foam_cell1.13420827
74MP0008775_abnormal_heart_ventricle1.13064634
75MP0005410_abnormal_fertilization1.09810340
76MP0004036_abnormal_muscle_relaxation1.04530706
77MP0002084_abnormal_developmental_patter1.04242866
78MP0006072_abnormal_retinal_apoptosis1.02388862
79MP0003221_abnormal_cardiomyocyte_apopto0.98502511
80MP0005266_abnormal_metabolism0.98400617
81MP0002086_abnormal_extraembryonic_tissu0.97317797
82MP0001929_abnormal_gametogenesis0.97109809
83MP0000358_abnormal_cell_content/0.96998626
84MP0002118_abnormal_lipid_homeostasis0.95902036
85MP0003195_calcinosis0.93228453
86MP0005253_abnormal_eye_physiology0.90485396
87MP0001188_hyperpigmentation0.90379118
88MP0002638_abnormal_pupillary_reflex0.89895203
89MP0002085_abnormal_embryonic_tissue0.88592825
90MP0001915_intracranial_hemorrhage0.87875680
91MP0000537_abnormal_urethra_morphology0.87784237
92MP0006035_abnormal_mitochondrial_morpho0.87459657
93MP0002009_preneoplasia0.86536777
94MP0000015_abnormal_ear_pigmentation0.85987454
95MP0005330_cardiomyopathy0.85949708
96MP0003121_genomic_imprinting0.83993014
97MP0002095_abnormal_skin_pigmentation0.83616169
98MP0009703_decreased_birth_body0.82553285
99MP0005395_other_phenotype0.82398438
100MP0003136_yellow_coat_color0.81895380
101MP0005076_abnormal_cell_differentiation0.81533961
102MP0001293_anophthalmia0.81408810
103MP0002396_abnormal_hematopoietic_system0.80350228
104MP0003567_abnormal_fetal_cardiomyocyte0.80326902
105MP0002234_abnormal_pharynx_morphology0.79569469
106MP0000749_muscle_degeneration0.79413754
107MP0003718_maternal_effect0.79352192
108MP0009643_abnormal_urine_homeostasis0.78490875
109MP0003183_abnormal_peptide_metabolism0.77920179
110MP0002019_abnormal_tumor_incidence0.77276544
111MP0002697_abnormal_eye_size0.77118081
112MP0004084_abnormal_cardiac_muscle0.75946764
113MP0000647_abnormal_sebaceous_gland0.74930462
114MP0002210_abnormal_sex_determination0.74005286
115MP0001145_abnormal_male_reproductive0.73557014
116MP0001299_abnormal_eye_distance/0.71095422
117MP0004133_heterotaxia0.70953204
118MP0002111_abnormal_tail_morphology0.70634100
119MP0004808_abnormal_hematopoietic_stem0.68814049
120MP0008995_early_reproductive_senescence0.68234178
121MP0005384_cellular_phenotype0.68173210
122MP0000313_abnormal_cell_death0.67313815
123MP0000653_abnormal_sex_gland0.66457859
124MP0004087_abnormal_muscle_fiber0.66253121
125MP0002928_abnormal_bile_duct0.66073874
126MP0002837_dystrophic_cardiac_calcinosis0.65600450
127MP0001243_abnormal_dermal_layer0.65331611
128MP0002078_abnormal_glucose_homeostasis0.65240477
129MP0000371_diluted_coat_color0.64649223
130MP0002160_abnormal_reproductive_system0.63624452
131MP0000747_muscle_weakness0.63408190
132MP0003763_abnormal_thymus_physiology0.63373360
133MP0002090_abnormal_vision0.62939470
134MP0000427_abnormal_hair_cycle0.62529855
135MP0008789_abnormal_olfactory_epithelium0.61958009
136MP0004130_abnormal_muscle_cell0.61320553
137MP0010678_abnormal_skin_adnexa0.61140561
138MP0003943_abnormal_hepatobiliary_system0.60953068
139MP0009046_muscle_twitch0.60878804
140MP0005376_homeostasis/metabolism_phenot0.60217920
141MP0001849_ear_inflammation0.59395505
142MP0002970_abnormal_white_adipose0.58881430

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.03015968
2Intrahepatic cholestasis (HP:0001406)4.15471643
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.14799966
4Deep venous thrombosis (HP:0002625)3.90686119
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.87366729
6Volvulus (HP:0002580)3.76098929
7Hypoglycemic coma (HP:0001325)3.66442073
8Chromsome breakage (HP:0040012)3.53657575
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47739918
10Abnormality of chromosome stability (HP:0003220)3.42847946
11Hypolipoproteinemia (HP:0010981)3.36177884
12Abnormality of sulfur amino acid metabolism (HP:0004339)3.29054085
13Abnormality of methionine metabolism (HP:0010901)3.19106093
14Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12388719
15Abnormality of pyrimidine metabolism (HP:0004353)3.07147284
16Abnormality of fatty-acid metabolism (HP:0004359)2.99778418
17Hyperammonemia (HP:0001987)2.98385898
18Meckel diverticulum (HP:0002245)2.94993150
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.92131869
20Abnormality of glycolysis (HP:0004366)2.91114535
21Increased serum pyruvate (HP:0003542)2.91114535
22Abnormality of the ileum (HP:0001549)2.89812031
23Ketosis (HP:0001946)2.88774970
24Xanthomatosis (HP:0000991)2.80164611
25Embryonal renal neoplasm (HP:0011794)2.79602417
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78137281
27Nephroblastoma (Wilms tumor) (HP:0002667)2.77353774
28Abnormality of the pancreatic islet cells (HP:0006476)2.76793020
29Abnormality of endocrine pancreas physiology (HP:0012093)2.76793020
30Fat malabsorption (HP:0002630)2.75497290
31Myoglobinuria (HP:0002913)2.74303450
32Hyperglycinemia (HP:0002154)2.73986620
33Epidermoid cyst (HP:0200040)2.72726785
34Cortical dysplasia (HP:0002539)2.72082177
35Abnormality of serine family amino acid metabolism (HP:0010894)2.71280021
36Abnormality of glycine metabolism (HP:0010895)2.71280021
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.66177127
38Hepatocellular carcinoma (HP:0001402)2.63985651
39Degeneration of anterior horn cells (HP:0002398)2.63021542
40Abnormality of the anterior horn cell (HP:0006802)2.63021542
41Ketoacidosis (HP:0001993)2.62333062
42Small intestinal stenosis (HP:0012848)2.61293131
43Duodenal stenosis (HP:0100867)2.61293131
44Back pain (HP:0003418)2.61290637
45Abnormality of the preputium (HP:0100587)2.57955190
46Abnormality of the intrinsic pathway (HP:0010989)2.57464592
47Nemaline bodies (HP:0003798)2.56956136
48Renal cortical cysts (HP:0000803)2.56810494
49Spastic diplegia (HP:0001264)2.55938606
50Hyperglycinuria (HP:0003108)2.55685843
51Type I transferrin isoform profile (HP:0003642)2.50251532
52Cerebral edema (HP:0002181)2.46330709
53Rhabdomyolysis (HP:0003201)2.43129460
54Acute necrotizing encephalopathy (HP:0006965)2.42858014
55Abnormal lung lobation (HP:0002101)2.42010828
56Abnormality of the lower motor neuron (HP:0002366)2.41525499
57Increased CSF lactate (HP:0002490)2.40384830
58Fair hair (HP:0002286)2.40174256
59Long clavicles (HP:0000890)2.39383909
60Abnormality of the common coagulation pathway (HP:0010990)2.37254455
61Muscle fiber inclusion bodies (HP:0100299)2.35871236
62Cholelithiasis (HP:0001081)2.35842150
63Calf muscle hypertrophy (HP:0008981)2.35318900
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33355152
65Pancreatic islet-cell hyperplasia (HP:0004510)2.33045214
66Abnormal gallbladder morphology (HP:0012437)2.32700102
67Myelodysplasia (HP:0002863)2.29233642
68Sloping forehead (HP:0000340)2.26675368
69Muscle hypertrophy of the lower extremities (HP:0008968)2.26583695
70Hypoalphalipoproteinemia (HP:0003233)2.26335301
71Ependymoma (HP:0002888)2.25091292
72Steatorrhea (HP:0002570)2.24686684
73Neoplasm of the adrenal gland (HP:0100631)2.24112929
74Hyperbilirubinemia (HP:0002904)2.22595991
75Conjunctival hamartoma (HP:0100780)2.21712427
76Abnormality of the duodenum (HP:0002246)2.21613609
77Hyperinsulinemic hypoglycemia (HP:0000825)2.20875926
78Hypoplasia of the pons (HP:0012110)2.20557881
79Hyperglycemia (HP:0003074)2.18719434
80Progressive macrocephaly (HP:0004481)2.18123754
81Abnormality of serum amino acid levels (HP:0003112)2.17836809
82Angiofibromas (HP:0010615)2.17706096
83Adenoma sebaceum (HP:0009720)2.17706096
84Abnormal mitochondria in muscle tissue (HP:0008316)2.16160684
85Abnormal protein glycosylation (HP:0012346)2.15017615
86Abnormal glycosylation (HP:0012345)2.15017615
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15017615
88Abnormal protein N-linked glycosylation (HP:0012347)2.15017615
89Hypoglycemic seizures (HP:0002173)2.14744186
90Exercise-induced muscle cramps (HP:0003710)2.10013533
91Increased serum lactate (HP:0002151)2.08251251
92Colon cancer (HP:0003003)2.07879751
93Acute myeloid leukemia (HP:0004808)2.07118269
94Ovarian neoplasm (HP:0100615)2.07023122
95Abnormality of the left ventricular outflow tract (HP:0011103)2.06597025
96Subaortic stenosis (HP:0001682)2.06597025
97Thyroid carcinoma (HP:0002890)2.05306931
98Increased hepatocellular lipid droplets (HP:0006565)2.04723456
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04213212
100Abnormality of alanine metabolism (HP:0010916)2.04213212
101Hyperalaninemia (HP:0003348)2.04213212
102Dicarboxylic aciduria (HP:0003215)2.04061157
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04061157
104Neoplasm of the rectum (HP:0100743)2.03779163
105Abnormal biliary tract morphology (HP:0012440)2.03045908
106Abnormality of the pons (HP:0007361)2.02343247
107Cholecystitis (HP:0001082)2.00591052
108Abnormal gallbladder physiology (HP:0012438)2.00591052
109Late onset (HP:0003584)2.00428929
110Intestinal polyposis (HP:0200008)1.99785780
111Brushfield spots (HP:0001088)1.99587918
112Papillary thyroid carcinoma (HP:0002895)1.98423935
113Increased nuchal translucency (HP:0010880)1.97797479
114Prolonged partial thromboplastin time (HP:0003645)1.97737097
115Methylmalonic acidemia (HP:0002912)1.97534002
116Abnormality of nucleobase metabolism (HP:0010932)1.96579656
117Neoplasm of the small intestine (HP:0100833)1.95443334
118Small hand (HP:0200055)1.95252517
119Glioma (HP:0009733)1.94514408
120Intestinal polyp (HP:0005266)1.94363254
121Lethargy (HP:0001254)1.94151565
122Lipid accumulation in hepatocytes (HP:0006561)1.93848250
123Abnormal cartilage morphology (HP:0002763)1.92253650
124Neoplasm of the adrenal cortex (HP:0100641)1.91878003
125Medial flaring of the eyebrow (HP:0010747)1.91090769
126Mitochondrial inheritance (HP:0001427)1.90984604
127Metaphyseal cupping (HP:0003021)1.90884515
128Multiple enchondromatosis (HP:0005701)1.90836890
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.89702526
130Abnormality of the calcaneus (HP:0008364)1.89353908
131Hypochromic microcytic anemia (HP:0004840)1.89208000
132Medulloblastoma (HP:0002885)1.88932175
133Neoplasm of the colon (HP:0100273)1.88893216
134Gout (HP:0001997)1.87914243
135Reduced antithrombin III activity (HP:0001976)1.87838201
136Birth length less than 3rd percentile (HP:0003561)1.87602723
137Intestinal atresia (HP:0011100)1.87272361
138Rhabdomyosarcoma (HP:0002859)1.85981057
139Cerebral hypomyelination (HP:0006808)1.85938160
140Acute hepatic failure (HP:0006554)1.84623864
141Neoplasm of the liver (HP:0002896)1.83514252
142Neoplasm of the peripheral nervous system (HP:0100007)1.81563350
143Biliary tract neoplasm (HP:0100574)1.79913994
144Abnormality of the labia minora (HP:0012880)1.78727935
145Abnormality of the astrocytes (HP:0100707)1.78568782
146Astrocytoma (HP:0009592)1.78568782
147Neuroendocrine neoplasm (HP:0100634)1.78545524
148Clubbing of toes (HP:0100760)1.77432677
149Cafe-au-lait spot (HP:0000957)1.76823009
150Reticulocytosis (HP:0001923)1.76178522
151Epiphyseal stippling (HP:0010655)1.76057968
152Dry hair (HP:0011359)1.75634556
153Short tibia (HP:0005736)1.75152626
154Lactic acidosis (HP:0003128)1.75002493
155Abnormality of the gallbladder (HP:0005264)1.74904709
156Oral leukoplakia (HP:0002745)1.74093790
157Embryonal neoplasm (HP:0002898)1.73943352
158Acute encephalopathy (HP:0006846)1.73800667
159Opisthotonus (HP:0002179)1.73770289
160Absent radius (HP:0003974)1.73462289
161Metabolic acidosis (HP:0001942)1.73160390
162Hyperlipoproteinemia (HP:0010980)1.73157983
163Prominent metopic ridge (HP:0005487)1.72957222
164Shoulder girdle muscle weakness (HP:0003547)1.72425066
165Hepatic necrosis (HP:0002605)1.71340435
166Abnormality of the renal cortex (HP:0011035)1.70092913
167Entropion (HP:0000621)1.68729754
168Abnormality of DNA repair (HP:0003254)1.68426088
169Abnormality of the carotid arteries (HP:0005344)1.68193060
170Microvesicular hepatic steatosis (HP:0001414)1.67917720
171Type II lissencephaly (HP:0007260)1.65886182
172Astigmatism (HP:0000483)1.65441855
173Congenital primary aphakia (HP:0007707)1.64311931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.38695957
2EIF2AK13.16764851
3CDC73.13870858
4PKN23.09965493
5BUB12.97601336
6PDK32.80548918
7PDK42.80548918
8PBK2.62240106
9PASK2.59612347
10BMPR1B2.48543504
11MST42.39868888
12EEF2K2.33954607
13TSSK62.32852730
14NEK12.32240785
15FLT32.23523206
16MKNK22.23160611
17EIF2AK32.06850518
18PDK22.03886983
19ACVR1B1.98388538
20WEE11.94746182
21TRIB31.92075748
22TESK21.88637844
23NUAK11.86049855
24TRIM281.83221463
25TESK11.82072064
26STK101.74800698
27TTK1.57894247
28PLK21.55949909
29BRSK21.51692484
30RPS6KB21.41660529
31NEK21.39748932
32MAP3K101.37580341
33MAP2K31.36898916
34TTN1.35988753
35SCYL21.33210052
36TAF11.32704735
37MAP3K81.31299726
38BCR1.30602464
39SRPK11.28518187
40MAP4K21.22066014
41LATS11.19644683
42TNIK1.19101277
43PLK31.18729423
44TGFBR11.18484984
45PRKD31.18001838
46ERN11.17672639
47ATR1.15165711
48BRD41.14239257
49PLK11.13308242
50CDK121.10682712
51MAPKAPK31.08190059
52AURKB1.05633427
53ERBB41.04063059
54STK38L1.03934808
55MET1.03350888
56EPHA21.03288791
57CDK81.03130586
58WNK31.00449111
59FGFR40.99822631
60CHEK10.97856854
61PLK40.96138217
62LRRK20.94724228
63VRK20.93373346
64BRSK10.89344797
65MTOR0.89077034
66SIK10.88557753
67PNCK0.85313266
68RPS6KA40.84184057
69AURKA0.81053325
70CCNB10.78855086
71STK30.77085083
72CSNK1G10.77071251
73MAP2K60.75640973
74CHEK20.73748296
75FGFR10.72518361
76PAK40.72077009
77CLK10.72015036
78STK40.71625106
79PTK60.71075797
80MAPK110.70792790
81ATM0.70361370
82CSNK1G30.68415371
83VRK10.67792680
84MELK0.67138659
85MAP3K40.66445707
86LIMK10.65617530
87TIE10.65530891
88CSNK1A1L0.63135778
89TEC0.62235653
90LATS20.61800698
91CDK40.60908835
92PRKCI0.60618422
93STK390.59889210
94MKNK10.59670632
95MAPK130.58675227
96NEK90.57014347
97MAPKAPK50.56670270
98CDK20.56421605
99CSNK1G20.54956114
100PDGFRA0.53590595
101PIM10.53227376
102GRK10.52679968
103RAF10.51738428
104PHKG10.50508307
105PHKG20.50508307
106CDK10.49310746
107CDK60.48439469
108CSNK2A20.47215761
109RPS6KB10.47026302
110EIF2AK20.46539642
111ERBB30.45889970
112PAK20.44959491
113NME10.44273392
114BRAF0.43727973
115BMPR20.43034994
116MAP3K30.42774452
117TLK10.42724788
118ALK0.42626562
119AKT30.41684512
120PIK3CG0.39367094
121CDK70.39306480
122NLK0.39140251
123MAP3K120.38872183
124ZAK0.38495887
125OBSCN0.38489550
126TRPM70.34578419
127CSNK2A10.34157439
128DYRK20.33335923
129ITK0.33188336
130PAK30.31988544
131RPS6KA50.29965222
132CDK30.28658385
133DAPK10.28357966
134PRKACB0.27970205
135WNK40.27735188
136STK240.27114703
137FER0.26773001
138ZAP700.26630399
139PRKDC0.25986435
140FRK0.24559974
141PAK10.24533880
142STK160.23808518
143PTK20.22875649
144GRK60.22155195
145CSNK1E0.21019969

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.85649462
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78165812
3One carbon pool by folate_Homo sapiens_hsa006702.77672252
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59249842
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56005395
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53934646
7Selenocompound metabolism_Homo sapiens_hsa004502.48382383
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.39347905
9Pyruvate metabolism_Homo sapiens_hsa006202.30916913
10Propanoate metabolism_Homo sapiens_hsa006402.28523510
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27658587
12Biosynthesis of amino acids_Homo sapiens_hsa012302.14173637
13Fatty acid degradation_Homo sapiens_hsa000712.11084670
14Carbon metabolism_Homo sapiens_hsa012002.07731559
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05186442
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.92509461
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87379099
18Mismatch repair_Homo sapiens_hsa034301.84026005
19DNA replication_Homo sapiens_hsa030301.84020177
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77929088
21Arginine biosynthesis_Homo sapiens_hsa002201.73857190
22Tryptophan metabolism_Homo sapiens_hsa003801.70918093
23RNA transport_Homo sapiens_hsa030131.68202379
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63393208
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.61621834
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.54821508
27Fatty acid metabolism_Homo sapiens_hsa012121.54538337
28Proteasome_Homo sapiens_hsa030501.49917172
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48092975
30Oocyte meiosis_Homo sapiens_hsa041141.42619388
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40557619
32Peroxisome_Homo sapiens_hsa041461.37651221
33Nitrogen metabolism_Homo sapiens_hsa009101.29595836
34Fat digestion and absorption_Homo sapiens_hsa049751.27834430
35Butanoate metabolism_Homo sapiens_hsa006501.27609240
36Base excision repair_Homo sapiens_hsa034101.26243709
37Cell cycle_Homo sapiens_hsa041101.25698469
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.23331108
39Nucleotide excision repair_Homo sapiens_hsa034201.23143033
40Spliceosome_Homo sapiens_hsa030401.20741963
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.19171746
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18344033
43Non-homologous end-joining_Homo sapiens_hsa034501.11147132
44Sulfur metabolism_Homo sapiens_hsa009201.10635206
45Pentose phosphate pathway_Homo sapiens_hsa000301.09196432
46Parkinsons disease_Homo sapiens_hsa050121.08622652
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03091777
48Oxidative phosphorylation_Homo sapiens_hsa001901.01465429
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97135449
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96199876
51Vitamin B6 metabolism_Homo sapiens_hsa007500.96048243
52Complement and coagulation cascades_Homo sapiens_hsa046100.95174506
53Pyrimidine metabolism_Homo sapiens_hsa002400.93708000
54Tyrosine metabolism_Homo sapiens_hsa003500.93597007
55Fatty acid elongation_Homo sapiens_hsa000620.90884115
56Lysine degradation_Homo sapiens_hsa003100.90258992
57RNA degradation_Homo sapiens_hsa030180.89410386
58Phenylalanine metabolism_Homo sapiens_hsa003600.88669581
59Folate biosynthesis_Homo sapiens_hsa007900.87250659
60Chemical carcinogenesis_Homo sapiens_hsa052040.86635898
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86350498
62Systemic lupus erythematosus_Homo sapiens_hsa053220.85788274
63Steroid biosynthesis_Homo sapiens_hsa001000.85623941
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85503066
65Protein export_Homo sapiens_hsa030600.85092077
66* mRNA surveillance pathway_Homo sapiens_hsa030150.83505834
67Starch and sucrose metabolism_Homo sapiens_hsa005000.83095576
68PPAR signaling pathway_Homo sapiens_hsa033200.82819685
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82068725
70Arginine and proline metabolism_Homo sapiens_hsa003300.80431228
71Sulfur relay system_Homo sapiens_hsa041220.79405880
72Huntingtons disease_Homo sapiens_hsa050160.77431857
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76459554
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74411245
75beta-Alanine metabolism_Homo sapiens_hsa004100.72303898
76Homologous recombination_Homo sapiens_hsa034400.72005654
77Histidine metabolism_Homo sapiens_hsa003400.70862014
78Regulation of autophagy_Homo sapiens_hsa041400.70096277
79Glutathione metabolism_Homo sapiens_hsa004800.69691005
80RNA polymerase_Homo sapiens_hsa030200.68461879
81Basal transcription factors_Homo sapiens_hsa030220.63250260
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62180607
83Alcoholism_Homo sapiens_hsa050340.62066038
84Viral carcinogenesis_Homo sapiens_hsa052030.60808377
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58950417
86Alzheimers disease_Homo sapiens_hsa050100.57737720
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57284112
88Fructose and mannose metabolism_Homo sapiens_hsa000510.56266547
89Retinol metabolism_Homo sapiens_hsa008300.55746294
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.55724931
91Phototransduction_Homo sapiens_hsa047440.54777369
92Circadian rhythm_Homo sapiens_hsa047100.53580120
93p53 signaling pathway_Homo sapiens_hsa041150.52662402
94Metabolic pathways_Homo sapiens_hsa011000.51932982
95Glycerolipid metabolism_Homo sapiens_hsa005610.51354504
96N-Glycan biosynthesis_Homo sapiens_hsa005100.46942615
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.45958443
98Epstein-Barr virus infection_Homo sapiens_hsa051690.45867689
99TGF-beta signaling pathway_Homo sapiens_hsa043500.45748038
100Galactose metabolism_Homo sapiens_hsa000520.40716093
101Renin-angiotensin system_Homo sapiens_hsa046140.39208556
102Glucagon signaling pathway_Homo sapiens_hsa049220.39091129
103Fanconi anemia pathway_Homo sapiens_hsa034600.38583136
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36990401
105Bile secretion_Homo sapiens_hsa049760.34790491
106Antigen processing and presentation_Homo sapiens_hsa046120.33717658
107Caffeine metabolism_Homo sapiens_hsa002320.32279208
108Vitamin digestion and absorption_Homo sapiens_hsa049770.32060928
109Purine metabolism_Homo sapiens_hsa002300.31839348
110ABC transporters_Homo sapiens_hsa020100.31315661
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30270700
112Cardiac muscle contraction_Homo sapiens_hsa042600.30043913
113Insulin resistance_Homo sapiens_hsa049310.28181732
114AMPK signaling pathway_Homo sapiens_hsa041520.27258747
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19997077
116Thyroid cancer_Homo sapiens_hsa052160.16970905
117Hippo signaling pathway_Homo sapiens_hsa043900.16860532
118Olfactory transduction_Homo sapiens_hsa047400.16090072
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13144807
120MicroRNAs in cancer_Homo sapiens_hsa052060.12929859
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06586539
122Tight junction_Homo sapiens_hsa045300.06293051
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.02804736
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.02563650
125Fatty acid biosynthesis_Homo sapiens_hsa000610.01867095
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00190691

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