HBZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)6.72028716
2cellular response to zinc ion (GO:0071294)6.21561222
3protoporphyrinogen IX metabolic process (GO:0046501)6.05013660
4proline biosynthetic process (GO:0006561)5.58820305
5cellular response to cadmium ion (GO:0071276)5.56912199
6nuclear pore complex assembly (GO:0051292)5.07598922
7protoporphyrinogen IX biosynthetic process (GO:0006782)5.01852346
8negative regulation of erythrocyte differentiation (GO:0045647)4.98233035
9regulation of translational fidelity (GO:0006450)4.69944819
10DNA unwinding involved in DNA replication (GO:0006268)4.62706105
11regulation of histone H3-K27 methylation (GO:0061085)4.52363947
12formation of translation preinitiation complex (GO:0001731)4.47069821
13diterpenoid biosynthetic process (GO:0016102)4.41691771
14nuclear pore organization (GO:0006999)4.39049878
15DNA replication initiation (GO:0006270)4.02414980
16hemoglobin metabolic process (GO:0020027)3.98198855
17regulation of histone H3-K4 methylation (GO:0051569)3.84537258
18terpenoid biosynthetic process (GO:0016114)3.83960020
19porphyrin-containing compound biosynthetic process (GO:0006779)3.82951763
20DNA topological change (GO:0006265)3.81966482
21DNA strand elongation involved in DNA replication (GO:0006271)3.80542342
22vitamin A metabolic process (GO:0006776)3.80233141
23mitotic sister chromatid segregation (GO:0000070)3.75553500
24pore complex assembly (GO:0046931)3.73834627
25mitotic nuclear envelope disassembly (GO:0007077)3.73759550
26oxidative phosphorylation (GO:0006119)3.72659963
27DNA strand elongation (GO:0022616)3.67282249
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.66198309
29homocysteine metabolic process (GO:0050667)3.66052938
30protein-cofactor linkage (GO:0018065)3.61593980
31proteasome assembly (GO:0043248)3.61506359
32synapsis (GO:0007129)3.60266118
33proline metabolic process (GO:0006560)3.59252766
34porphyrin-containing compound metabolic process (GO:0006778)3.58888466
35ribosomal small subunit assembly (GO:0000028)3.54669704
36telomere maintenance via semi-conservative replication (GO:0032201)3.52976855
37oxaloacetate metabolic process (GO:0006107)3.52065004
38sister chromatid segregation (GO:0000819)3.51426912
39membrane disassembly (GO:0030397)3.48806680
40nuclear envelope disassembly (GO:0051081)3.48806680
41heme biosynthetic process (GO:0006783)3.45336677
42ribosomal large subunit biogenesis (GO:0042273)3.38944379
43regulation of RNA export from nucleus (GO:0046831)3.37868366
44regulation of DNA methylation (GO:0044030)3.35980579
45mucosal-associated lymphoid tissue development (GO:0048537)3.35234920
46Peyers patch development (GO:0048541)3.35234920
47viral transcription (GO:0019083)3.32704801
48tetrapyrrole biosynthetic process (GO:0033014)3.31237485
49glucose 6-phosphate metabolic process (GO:0051156)3.29773640
50creatine metabolic process (GO:0006600)3.26901718
51translational termination (GO:0006415)3.24293885
52response to vitamin A (GO:0033189)3.23811625
53meiotic chromosome segregation (GO:0045132)3.20807899
54granulocyte differentiation (GO:0030851)3.18610616
55protein export from nucleus (GO:0006611)3.18360131
56autophagic vacuole fusion (GO:0000046)3.18266986
57maturation of SSU-rRNA (GO:0030490)3.17609160
58negative regulation of histone methylation (GO:0031061)3.16591220
59resolution of meiotic recombination intermediates (GO:0000712)3.13319444
60heme metabolic process (GO:0042168)3.13183602
61mitotic chromosome condensation (GO:0007076)3.08172175
62phosphorelay signal transduction system (GO:0000160)3.07332570
63erythrocyte development (GO:0048821)3.06098249
64regulation of mitotic spindle organization (GO:0060236)3.05795005
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05578037
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03478212
67translational initiation (GO:0006413)3.00367620
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98292209
69protein K11-linked deubiquitination (GO:0035871)2.96251885
70potassium ion export (GO:0071435)2.93351374
71DNA synthesis involved in DNA repair (GO:0000731)2.92918282
72translational elongation (GO:0006414)2.92664588
73pentose metabolic process (GO:0019321)2.92416874
74purine nucleobase biosynthetic process (GO:0009113)2.92268437
75telomere maintenance via recombination (GO:0000722)2.90808050
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90807211
77mitotic recombination (GO:0006312)2.90560406
78nucleobase biosynthetic process (GO:0046112)2.89805427
79* erythrocyte maturation (GO:0043249)2.89529723
80DNA damage induced protein phosphorylation (GO:0006975)2.89007605
81regulation of translational elongation (GO:0006448)2.83727616
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83201432
83ATP biosynthetic process (GO:0006754)2.83170304
84regulation of response to osmotic stress (GO:0047484)2.81541244
85succinate metabolic process (GO:0006105)2.80660003
86neutrophil activation involved in immune response (GO:0002283)2.79692657
87protein complex disassembly (GO:0043241)2.78343193
88cellular protein complex disassembly (GO:0043624)2.76685716
89ATP synthesis coupled proton transport (GO:0015986)2.75564605
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75564605
91cotranslational protein targeting to membrane (GO:0006613)2.74921549
92regulation of histone methylation (GO:0031060)2.74717252
93IMP biosynthetic process (GO:0006188)2.74540844
94definitive hemopoiesis (GO:0060216)2.73651299
95folic acid-containing compound biosynthetic process (GO:0009396)2.73626691
96tetrahydrofolate metabolic process (GO:0046653)2.73058371
97membrane repolarization during action potential (GO:0086011)2.72131963
98protein targeting to ER (GO:0045047)2.69822989
99* oxygen transport (GO:0015671)13.4285778
100* gas transport (GO:0015669)11.7329621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.82564651
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05122774
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.45794401
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44696192
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.35061644
6GATA1_19941826_ChIP-Seq_K562_Human3.18718773
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07575917
8NCOR1_26117541_ChIP-Seq_K562_Human2.86953391
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44504334
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43977099
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.43922948
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.42167206
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41520933
14XRN2_22483619_ChIP-Seq_HELA_Human2.40912099
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38519299
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.36651869
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24023037
18GATA1_22025678_ChIP-Seq_K562_Human2.21760771
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20330145
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16102044
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08933976
22GATA2_19941826_ChIP-Seq_K562_Human1.99178766
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98202806
24DCP1A_22483619_ChIP-Seq_HELA_Human1.84186220
25TTF2_22483619_ChIP-Seq_HELA_Human1.82306787
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.76706643
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75263178
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74902983
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63912138
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63239785
31CIITA_25753668_ChIP-Seq_RAJI_Human1.63089382
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.61022632
33KDM5A_27292631_Chip-Seq_BREAST_Human1.58492882
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58416227
35MYC_22102868_ChIP-Seq_BL_Human1.56724836
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52503910
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52372225
38FOXP3_21729870_ChIP-Seq_TREG_Human1.52108940
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51677545
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51677545
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51677545
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51476300
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51230154
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51084244
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48055895
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45752177
47GABP_19822575_ChIP-Seq_HepG2_Human1.39941505
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39849577
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.39179151
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38220131
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36574561
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35564061
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35339170
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33332600
55AR_21909140_ChIP-Seq_LNCAP_Human1.31248409
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27323054
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26495082
58ZNF263_19887448_ChIP-Seq_K562_Human1.25462673
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22080711
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21125056
61ELK1_19687146_ChIP-ChIP_HELA_Human1.20710845
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17947842
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17503625
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16684268
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16266490
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15700685
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14319573
68VDR_23849224_ChIP-Seq_CD4+_Human1.14292124
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13860373
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13478763
71SCL_19346495_ChIP-Seq_HPC-7_Human1.10205133
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.10092038
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09271414
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08639824
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08075272
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07112011
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06027506
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05520172
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03805298
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.01585236
81SPI1_23127762_ChIP-Seq_K562_Human1.01240322
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00643183
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00446341
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00301210
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99615460
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98529030
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.96631690
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95588014
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93644331
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92721110
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91930321
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91685957
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.88830559
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88236401
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88056208
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87137451
97TFEB_21752829_ChIP-Seq_HELA_Human0.85948238
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84955906
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84706592
100CHD1_26751641_Chip-Seq_LNCaP_Human0.81887796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.38668040
2MP0008995_early_reproductive_senescence5.09219259
3MP0004957_abnormal_blastocyst_morpholog4.36450559
4MP0005377_hearing/vestibular/ear_phenot3.62118426
5MP0003878_abnormal_ear_physiology3.62118426
6MP0003656_abnormal_erythrocyte_physiolo3.47374554
7MP0003111_abnormal_nucleus_morphology3.38778144
8MP0000678_abnormal_parathyroid_gland3.34086032
9MP0010094_abnormal_chromosome_stability3.23558184
10MP0004145_abnormal_muscle_electrophysio3.00288038
11MP0008058_abnormal_DNA_repair2.66701382
12MP0005645_abnormal_hypothalamus_physiol2.58380633
13MP0003786_premature_aging2.57302548
14MP0003186_abnormal_redox_activity2.38095415
15MP0003693_abnormal_embryo_hatching2.14417250
16MP0005083_abnormal_biliary_tract2.13093303
17MP0008932_abnormal_embryonic_tissue2.11293376
18MP0005171_absent_coat_pigmentation1.95726412
19MP0001545_abnormal_hematopoietic_system1.89658632
20MP0005397_hematopoietic_system_phenotyp1.89658632
21MP0003077_abnormal_cell_cycle1.87159446
22MP0003123_paternal_imprinting1.81594813
23MP0008007_abnormal_cellular_replicative1.71760562
24MP0000372_irregular_coat_pigmentation1.70787498
25MP0005451_abnormal_body_composition1.67868471
26MP0009697_abnormal_copulation1.62650392
27MP0000350_abnormal_cell_proliferation1.59974288
28MP0009278_abnormal_bone_marrow1.59867638
29MP0003959_abnormal_lean_body1.56639303
30MP0001730_embryonic_growth_arrest1.54277221
31MP0006036_abnormal_mitochondrial_physio1.48622872
32MP0008775_abnormal_heart_ventricle1.47211158
33MP0010307_abnormal_tumor_latency1.44044789
34MP0005636_abnormal_mineral_homeostasis1.43881496
35MP0002396_abnormal_hematopoietic_system1.43860788
36MP0003567_abnormal_fetal_cardiomyocyte1.43292871
37MP0002086_abnormal_extraembryonic_tissu1.40643838
38MP0001672_abnormal_embryogenesis/_devel1.40392571
39MP0005380_embryogenesis_phenotype1.40392571
40MP0002080_prenatal_lethality1.39863748
41MP0001697_abnormal_embryo_size1.39551035
42MP0003984_embryonic_growth_retardation1.37148869
43MP0000313_abnormal_cell_death1.36413953
44MP0002088_abnormal_embryonic_growth/wei1.32283600
45MP0002132_abnormal_respiratory_system1.25913377
46MP0002210_abnormal_sex_determination1.24306983
47MP0008260_abnormal_autophagy1.23609118
48MP0001929_abnormal_gametogenesis1.23459243
49MP0002249_abnormal_larynx_morphology1.22918269
50MP0003718_maternal_effect1.19649031
51MP0001529_abnormal_vocalization1.19458086
52MP0003385_abnormal_body_wall1.09904620
53MP0006035_abnormal_mitochondrial_morpho1.08173925
54MP0003699_abnormal_female_reproductive0.96863200
55MP0003705_abnormal_hypodermis_morpholog0.95438621
56MP0003698_abnormal_male_reproductive0.93932982
57MP0002085_abnormal_embryonic_tissue0.92881171
58MP0000681_abnormal_thyroid_gland0.89818851
59MP0004197_abnormal_fetal_growth/weight/0.89486086
60MP0002019_abnormal_tumor_incidence0.89216772
61MP0002084_abnormal_developmental_patter0.85698101
62MP0008057_abnormal_DNA_replication0.82280012
63MP0005408_hypopigmentation0.81841616
64MP0002877_abnormal_melanocyte_morpholog0.81590602
65MP0009931_abnormal_skin_appearance0.81455426
66MP0001145_abnormal_male_reproductive0.79636360
67MP0001502_abnormal_circadian_rhythm0.79307500
68MP0002161_abnormal_fertility/fecundity0.79018921
69MP0000653_abnormal_sex_gland0.77611680
70MP0009672_abnormal_birth_weight0.77052464
71MP0001661_extended_life_span0.76745856
72MP0001119_abnormal_female_reproductive0.76577933
73MP0003942_abnormal_urinary_system0.75733699
74MP0005410_abnormal_fertilization0.75006274
75MP0008770_decreased_survivor_rate0.73741201
76MP0004858_abnormal_nervous_system0.71642400
77MP0002722_abnormal_immune_system0.71490996
78MP0005187_abnormal_penis_morphology0.70584930
79MP0000703_abnormal_thymus_morphology0.69060505
80MP0003806_abnormal_nucleotide_metabolis0.68681142
81MP0008877_abnormal_DNA_methylation0.67635394
82MP0003221_abnormal_cardiomyocyte_apopto0.66647464
83MP0000358_abnormal_cell_content/0.66490624
84MP0003890_abnormal_embryonic-extraembry0.64515824
85MP0000609_abnormal_liver_physiology0.62917897
86MP0001879_abnormal_lymphatic_vessel0.62376742
87MP0001727_abnormal_embryo_implantation0.61689383
88MP0001485_abnormal_pinna_reflex0.58595654
89MP0004808_abnormal_hematopoietic_stem0.58518675
90MP0004019_abnormal_vitamin_homeostasis0.58195652
91MP0004233_abnormal_muscle_weight0.58172616
92MP0008438_abnormal_cutaneous_collagen0.57720389
93MP0005076_abnormal_cell_differentiation0.53496937
94MP0004859_abnormal_synaptic_plasticity0.52839205
95MP0004381_abnormal_hair_follicle0.52363454
96MP0009703_decreased_birth_body0.52017813
97MP0000428_abnormal_craniofacial_morphol0.51635901
98MP0005384_cellular_phenotype0.51480435
99MP0010630_abnormal_cardiac_muscle0.50115957
100MP0002970_abnormal_white_adipose0.49977527

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal hemoglobin (HP:0011902)8.59913591
2Abnormality of the heme biosynthetic pathway (HP:0010472)8.59152274
3Abnormal gallbladder physiology (HP:0012438)7.54025114
4Cholecystitis (HP:0001082)7.54025114
5Reticulocytosis (HP:0001923)7.44039177
6Abnormality of reticulocytes (HP:0004312)6.12455577
7Chromosomal breakage induced by crosslinking agents (HP:0003221)5.29173360
8Truncus arteriosus (HP:0001660)5.14643221
9Chromsome breakage (HP:0040012)5.00828685
10Polycythemia (HP:0001901)4.75244309
11Pallor (HP:0000980)4.73867123
12Hyperthyroidism (HP:0000836)4.32617880
13Ileus (HP:0002595)3.87301070
14Cholelithiasis (HP:0001081)3.85249018
15Abnormality of cochlea (HP:0000375)3.64931973
16Abnormal number of erythroid precursors (HP:0012131)3.59625987
17Poikilocytosis (HP:0004447)3.48409503
18Hypertensive crisis (HP:0100735)3.45976739
19Abnormality of cells of the erythroid lineage (HP:0012130)3.45004254
20Abnormal gallbladder morphology (HP:0012437)3.39321150
21Reticulocytopenia (HP:0001896)3.34667977
22Morphological abnormality of the inner ear (HP:0011390)3.23718833
23Ankyloglossia (HP:0010296)3.21247376
24Birth length less than 3rd percentile (HP:0003561)3.21195302
25Abnormality of homocysteine metabolism (HP:0010919)3.14034666
26Homocystinuria (HP:0002156)3.14034666
27Bowel incontinence (HP:0002607)3.11552776
28Seborrheic dermatitis (HP:0001051)3.11164031
29Conjunctival hamartoma (HP:0100780)3.04111347
30Adenoma sebaceum (HP:0009720)3.01608261
31Angiofibromas (HP:0010615)3.01608261
32Abnormal large intestine physiology (HP:0012700)2.92265192
33Abnormality of the renal collecting system (HP:0004742)2.89951959
34Abnormality of the gallbladder (HP:0005264)2.80820194
35Hypochromic microcytic anemia (HP:0004840)2.72625911
36Nonimmune hydrops fetalis (HP:0001790)2.71010700
37Abnormality of the tricuspid valve (HP:0001702)2.64271330
38Atelectasis (HP:0100750)2.60327000
39Acanthocytosis (HP:0001927)2.59682379
40Hyperbilirubinemia (HP:0002904)2.57253535
41Duplicated collecting system (HP:0000081)2.43632092
42Hypoparathyroidism (HP:0000829)2.41910464
43Hepatocellular carcinoma (HP:0001402)2.37391933
44Nephroblastoma (Wilms tumor) (HP:0002667)2.35400796
45Hamartoma of the eye (HP:0010568)2.34259147
46Aplastic anemia (HP:0001915)2.33740968
47Microcytic anemia (HP:0001935)2.31720977
48Disproportionate tall stature (HP:0001519)2.29331360
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.24907835
50Abnormality of glycolysis (HP:0004366)2.24341255
51Upper limb muscle weakness (HP:0003484)2.22463369
52Progressive macrocephaly (HP:0004481)2.22347754
53Abnormality of oral frenula (HP:0000190)2.15662399
54Breast hypoplasia (HP:0003187)2.15487926
55Embryonal renal neoplasm (HP:0011794)2.15240145
56Meningioma (HP:0002858)2.12332825
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.05762310
58Abnormality of the preputium (HP:0100587)2.05477502
59Insomnia (HP:0100785)2.04033583
60Septate vagina (HP:0001153)2.03347956
61Myelodysplasia (HP:0002863)2.03252895
62Sandal gap (HP:0001852)1.99893358
63Meckel diverticulum (HP:0002245)1.98482934
64Cafe-au-lait spot (HP:0000957)1.93149530
65Medulloblastoma (HP:0002885)1.92363868
66Flat cornea (HP:0007720)1.85251512
67Aplasia/Hypoplasia of the thymus (HP:0010515)1.83834249
68Acute myeloid leukemia (HP:0004808)1.82582537
69Diaphragmatic weakness (HP:0009113)1.82409690
70Macrocytic anemia (HP:0001972)1.81823151
71Abnormality of chromosome stability (HP:0003220)1.81769596
72Abnormality of the ileum (HP:0001549)1.81669724
73Orthostatic hypotension (HP:0001278)1.81250826
74Peripheral hypomyelination (HP:0007182)1.81003306
75Duodenal stenosis (HP:0100867)1.80848590
76Small intestinal stenosis (HP:0012848)1.80848590
77Toxemia of pregnancy (HP:0100603)1.80696094
78Abnormality of DNA repair (HP:0003254)1.79297258
79Arteriovenous malformation (HP:0100026)1.75869894
80Large earlobe (HP:0009748)1.74696032
81Scotoma (HP:0000575)1.74575724
82Abnormally folded helix (HP:0008544)1.74011506
83Degeneration of anterior horn cells (HP:0002398)1.71458759
84Abnormality of the anterior horn cell (HP:0006802)1.71458759
85Attention deficit hyperactivity disorder (HP:0007018)1.69853259
86Embryonal neoplasm (HP:0002898)1.69294999
87Abnormality of sulfur amino acid metabolism (HP:0004339)1.68974248
88Myopathic facies (HP:0002058)1.66924809
89Abnormality of the carotid arteries (HP:0005344)1.65111896
90Ventricular fibrillation (HP:0001663)1.63317155
91Increased serum pyruvate (HP:0003542)1.62072958
92Abnormal mitochondria in muscle tissue (HP:0008316)1.60447352
93Dysmetric saccades (HP:0000641)1.59488697
94Acute necrotizing encephalopathy (HP:0006965)1.58508261
95Neoplasm of the rectum (HP:0100743)1.52686895
96Gastrointestinal dysmotility (HP:0002579)1.52575085
97Gonadal dysgenesis (HP:0000133)1.52208471
98Cheekbone underdevelopment (HP:0010669)1.51959484
99Paralysis (HP:0003470)1.51687238
100Neoplasm of the small intestine (HP:0100833)1.51346996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.40955190
2KSR23.74789151
3EEF2K3.60813451
4CDC73.48121579
5CLK13.45516481
6TTK3.08665390
7MAP3K22.85893996
8NTRK32.62371860
9RIPK42.47557586
10RAF12.39790330
11ICK2.05252086
12KSR12.01323033
13WEE11.98349148
14NEK11.92073977
15MAP3K41.87538626
16SRPK11.85913441
17TSSK61.60422587
18BUB11.59569955
19MAP3K81.46219253
20BMX1.37100807
21RPS6KB21.36717044
22BMPR21.36250804
23CDK121.35517080
24PLK41.34576120
25MAP3K61.26665386
26TRPM71.23452194
27MAP2K31.23206786
28NME11.22172578
29WNK41.22100158
30BRSK11.21315201
31IRAK31.20354189
32NEK21.18405006
33TRIB31.15384966
34CCNB11.09352799
35NME21.08800090
36MAP3K101.07429340
37ATR1.05761133
38RET1.03620047
39CHEK21.03332764
40MAPKAPK50.98132306
41CHEK10.93559154
42MAPKAPK30.93510194
43SMG10.87661302
44SCYL20.86915139
45MAP2K40.85364348
46MKNK10.81329182
47ILK0.80665213
48MAP2K60.80526872
49TYRO30.77768390
50BRSK20.77751598
51PAK10.76904958
52STK40.76677859
53BRAF0.75039669
54MKNK20.74222453
55CDK10.73731361
56EIF2AK30.71879722
57MARK30.70700554
58JAK20.69295543
59PLK10.67921242
60CDK20.67673524
61MAP2K10.66676786
62PRPF4B0.65049572
63ATM0.64841779
64MAP3K70.64416879
65MAP3K10.64302442
66PDK20.63808660
67PKN20.59864885
68MTOR0.59726251
69EPHA30.56635749
70JAK30.54076659
71PLK30.53327393
72FGFR40.51965249
73PTK60.51430528
74TAOK20.51033837
75AURKB0.50521442
76WNK10.49247309
77IRAK10.49123632
78BRD40.49003049
79AKT30.48700154
80BTK0.47951480
81MAPK100.47429029
82NTRK10.46989668
83LRRK20.46874190
84CSNK1E0.46613211
85AKT20.44348676
86MAPK120.43004718
87CDK70.42414066
88CDK11A0.41674367
89CDK40.40626298
90CSNK2A20.39648356
91PBK0.37783504
92ALK0.35976642
93CDK150.35929486
94CSNK2A10.34779613
95GSK3B0.34154317
96LATS20.34081937
97SGK10.33044771
98PIM10.30701011
99CDK180.30509334
100FGFR30.29994014

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.03612827
2DNA replication_Homo sapiens_hsa030303.63648734
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.02973056
4Homologous recombination_Homo sapiens_hsa034402.96497243
5Mismatch repair_Homo sapiens_hsa034302.95936730
6Ribosome_Homo sapiens_hsa030102.81704821
7One carbon pool by folate_Homo sapiens_hsa006702.81602161
8Spliceosome_Homo sapiens_hsa030402.61659222
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.22974028
10RNA transport_Homo sapiens_hsa030132.13651740
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11224476
12Oxidative phosphorylation_Homo sapiens_hsa001902.08805438
13Mineral absorption_Homo sapiens_hsa049782.00809944
14Acute myeloid leukemia_Homo sapiens_hsa052211.95223050
15Parkinsons disease_Homo sapiens_hsa050121.92266726
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89343173
17Biosynthesis of amino acids_Homo sapiens_hsa012301.83944842
18Cell cycle_Homo sapiens_hsa041101.80917878
19Pyruvate metabolism_Homo sapiens_hsa006201.78152393
20Fanconi anemia pathway_Homo sapiens_hsa034601.76955755
21Nucleotide excision repair_Homo sapiens_hsa034201.71244851
22Carbon metabolism_Homo sapiens_hsa012001.64390408
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54051052
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53632329
25Base excision repair_Homo sapiens_hsa034101.53111899
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49626079
27Chronic myeloid leukemia_Homo sapiens_hsa052201.45942608
28mRNA surveillance pathway_Homo sapiens_hsa030151.44387325
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.34448620
30Huntingtons disease_Homo sapiens_hsa050161.33341948
31Pentose phosphate pathway_Homo sapiens_hsa000301.29246703
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27911715
33VEGF signaling pathway_Homo sapiens_hsa043701.27742926
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.25545868
35Thyroid cancer_Homo sapiens_hsa052161.24779282
36Fructose and mannose metabolism_Homo sapiens_hsa000511.18615001
37Type II diabetes mellitus_Homo sapiens_hsa049301.18221006
38Steroid biosynthesis_Homo sapiens_hsa001001.16400128
39Alzheimers disease_Homo sapiens_hsa050101.14982976
40Non-small cell lung cancer_Homo sapiens_hsa052231.10175133
41mTOR signaling pathway_Homo sapiens_hsa041501.05321191
42Malaria_Homo sapiens_hsa051441.02512788
43HIF-1 signaling pathway_Homo sapiens_hsa040661.00847808
44Renal cell carcinoma_Homo sapiens_hsa052110.98280634
45Proteasome_Homo sapiens_hsa030500.97820424
46Oocyte meiosis_Homo sapiens_hsa041140.97782561
47Pancreatic cancer_Homo sapiens_hsa052120.96169020
48ErbB signaling pathway_Homo sapiens_hsa040120.94698287
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94015587
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86651213
51RNA degradation_Homo sapiens_hsa030180.85698795
52Insulin signaling pathway_Homo sapiens_hsa049100.80357003
53Cardiac muscle contraction_Homo sapiens_hsa042600.78409934
54Nicotine addiction_Homo sapiens_hsa050330.77948550
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76574064
56Glioma_Homo sapiens_hsa052140.76259253
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.75766210
58Endometrial cancer_Homo sapiens_hsa052130.71848319
59Prion diseases_Homo sapiens_hsa050200.70795792
60Purine metabolism_Homo sapiens_hsa002300.69367719
61Olfactory transduction_Homo sapiens_hsa047400.67875947
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.67709248
63Pyrimidine metabolism_Homo sapiens_hsa002400.66883565
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66098940
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65765213
66Bladder cancer_Homo sapiens_hsa052190.65077162
67RNA polymerase_Homo sapiens_hsa030200.63969637
68Protein export_Homo sapiens_hsa030600.60902847
69Colorectal cancer_Homo sapiens_hsa052100.59472479
70Basal transcription factors_Homo sapiens_hsa030220.57363468
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55855379
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51983316
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51288139
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49298632
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45214953
76Arginine biosynthesis_Homo sapiens_hsa002200.44337492
77Epstein-Barr virus infection_Homo sapiens_hsa051690.41270363
78Nitrogen metabolism_Homo sapiens_hsa009100.40015890
79Selenocompound metabolism_Homo sapiens_hsa004500.38039750
80Synaptic vesicle cycle_Homo sapiens_hsa047210.36614324
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35580460
82Prolactin signaling pathway_Homo sapiens_hsa049170.33565884
83Viral carcinogenesis_Homo sapiens_hsa052030.31995554
84N-Glycan biosynthesis_Homo sapiens_hsa005100.31043801
85B cell receptor signaling pathway_Homo sapiens_hsa046620.30073798
86MicroRNAs in cancer_Homo sapiens_hsa052060.29814759
87Metabolic pathways_Homo sapiens_hsa011000.29525492
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28767967
89Choline metabolism in cancer_Homo sapiens_hsa052310.27172202
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24259486
91AMPK signaling pathway_Homo sapiens_hsa041520.23717794
92Long-term potentiation_Homo sapiens_hsa047200.22553415
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21445461
94Tyrosine metabolism_Homo sapiens_hsa003500.21028120
95Non-homologous end-joining_Homo sapiens_hsa034500.20423887
96Galactose metabolism_Homo sapiens_hsa000520.19575959
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19431644
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17938378
99Prostate cancer_Homo sapiens_hsa052150.17722351
100Melanoma_Homo sapiens_hsa052180.16639623

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