ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to zinc ion (GO:0071294)	8.20500937
2	erythrocyte maturation (GO:0043249)	7.45587288
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.45091716
4	ATP synthesis coupled proton transport (GO:0015986)	7.12148712
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.12148712
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	7.11108570
7	respiratory electron transport chain (GO:0022904)	6.61648199
8	electron transport chain (GO:0022900)	6.41460353
9	cellular response to cadmium ion (GO:0071276)	6.04003979
10	neutrophil activation involved in immune response (GO:0002283)	5.10713589
11	leukotriene biosynthetic process (GO:0019370)	4.90037285
12	protein-cofactor linkage (GO:0018065)	4.76913342
13	proteasome assembly (GO:0043248)	4.67052330
14	hydrogen ion transmembrane transport (GO:1902600)	4.66943904
15	hemoglobin metabolic process (GO:0020027)	4.63653483
16	viral transcription (GO:0019083)	4.62292145
17	peptide catabolic process (GO:0043171)	4.52566887
18	translational termination (GO:0006415)	4.50000004
19	autophagic vacuole fusion (GO:0000046)	4.49726305
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.38634448
21	regulation of oxidative phosphorylation (GO:0002082)	4.37090807
22	signal peptide processing (GO:0006465)	4.29340467
23	cotranslational protein targeting to membrane (GO:0006613)	4.27481950
24	protein targeting to ER (GO:0045047)	4.22526282
25	negative regulation of heart rate (GO:0010459)	4.21740347
26	regulation of cellular respiration (GO:0043457)	4.20146508
27	ribosomal small subunit assembly (GO:0000028)	4.15603263
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.14885340
29	ATP biosynthetic process (GO:0006754)	4.13885407
30	protein localization to endoplasmic reticulum (GO:0070972)	4.08734855
31	proton transport (GO:0015992)	4.06580894
32	chaperone-mediated protein transport (GO:0072321)	4.06400179
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.03884152
34	oxidative phosphorylation (GO:0006119)	3.99270986
35	hydrogen transport (GO:0006818)	3.97598139
36	one-carbon compound transport (GO:0019755)	3.80055491
37	translational elongation (GO:0006414)	3.79786564
38	organelle membrane fusion (GO:0090174)	3.74386638
39	tyrosine metabolic process (GO:0006570)	3.61639890
40	translational initiation (GO:0006413)	3.61273764
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.53136944
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.45236832
43	cellular protein complex disassembly (GO:0043624)	3.44973552
44	protein prenylation (GO:0018342)	3.44861351
45	prenylation (GO:0097354)	3.44861351
46	spliceosomal complex assembly (GO:0000245)	3.44841188
47	ribosomal large subunit biogenesis (GO:0042273)	3.42540265
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.41018766
49	terpenoid biosynthetic process (GO:0016114)	3.39257299
50	response to zinc ion (GO:0010043)	3.38469568
51	histone mRNA metabolic process (GO:0008334)	3.37469873
52	protein K11-linked deubiquitination (GO:0035871)	3.31452981
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.31069113
54	heme biosynthetic process (GO:0006783)	3.30478462
55	negative regulation of cAMP-mediated signaling (GO:0043951)	3.30182986
56	translation (GO:0006412)	3.28906816
57	heme metabolic process (GO:0042168)	3.23955558
58	protein complex biogenesis (GO:0070271)	3.22890644
59	leukotriene metabolic process (GO:0006691)	3.20751514
60	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19432401
61	NADH dehydrogenase complex assembly (GO:0010257)	3.19432401
62	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19432401
63	cullin deneddylation (GO:0010388)	3.17962713
64	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.14927803
65	DNA deamination (GO:0045006)	3.10374339
66	artery smooth muscle contraction (GO:0014824)	3.07546452
67	viral life cycle (GO:0019058)	3.05801466
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.00329051
69	thyroid hormone generation (GO:0006590)	2.98158664
70	DNA replication checkpoint (GO:0000076)	2.95894781
71	response to copper ion (GO:0046688)	2.95598141
72	response to pheromone (GO:0019236)	2.94825380
73	base-excision repair, AP site formation (GO:0006285)	2.90703329
74	cellular response to superoxide (GO:0071451)	2.90025312
75	cellular response to oxygen radical (GO:0071450)	2.90025312
76	removal of superoxide radicals (GO:0019430)	2.90025312
77	response to cadmium ion (GO:0046686)	2.89513768
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88534575
79	protein deneddylation (GO:0000338)	2.88265511
80	protein targeting to membrane (GO:0006612)	2.87295768
81	cellular response to leptin stimulus (GO:0044320)	2.87097290
82	regulation of cilium movement (GO:0003352)	2.86349305
83	protein complex disassembly (GO:0043241)	2.86258616
84	response to oxygen radical (GO:0000305)	2.84909794
85	cellular respiration (GO:0045333)	2.81763573
86	negative regulation of response to food (GO:0032096)	2.81429333
87	negative regulation of appetite (GO:0032099)	2.81429333
88	response to superoxide (GO:0000303)	2.81092498
89	L-methionine biosynthetic process (GO:0071265)	2.79918582
90	amino acid salvage (GO:0043102)	2.79918582
91	L-methionine salvage (GO:0071267)	2.79918582
92	positive regulation of granulocyte differentiation (GO:0030854)	2.77861626
93	thyroid hormone metabolic process (GO:0042403)	2.75162307
94	macromolecular complex disassembly (GO:0032984)	2.74647091
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.74467481
96	glutathione metabolic process (GO:0006749)	2.74358845
97	protein targeting to mitochondrion (GO:0006626)	2.74108838
98	positive regulation of fibroblast migration (GO:0010763)	2.73964085
99	oxygen transport (GO:0015671)	14.0822674
100	gas transport (GO:0015669)	11.6020498

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	8.06418543
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.33804465
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.84470711
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.66431737
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55677707
6	ELK1_19687146_ChIP-ChIP_HELA_Human	2.76746325
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.62620911
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.56808528
9	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.54658341
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.52524664
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.52186676
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.46615730
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.44639863
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.40502213
15	VDR_22108803_ChIP-Seq_LS180_Human	2.34868799
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.27525625
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25789281
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.12769421
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.11605020
20	TP53_22573176_ChIP-Seq_HFKS_Human	2.04172876
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80705437
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79925272
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79265595
24	GATA1_22025678_ChIP-Seq_K562_Human	1.76335841
25	GATA1_19941826_ChIP-Seq_K562_Human	1.70097534
26	EGR1_19032775_ChIP-ChIP_M12_Human	1.69617451
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67483454
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65892119
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.62531904
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.55145996
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.47171422
32	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.44928604
33	RBPJ_21746931_ChIP-Seq_IB4_Human	1.44093726
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42339846
35	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39086801
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35235111
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34437009
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.28832870
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28639895
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.26361003
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.25940404
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24816253
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.22534056
44	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.21223944
45	ETV1_20927104_ChIP-Seq_GIST48_Human	1.20573091
46	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19070687
47	SPI1_23547873_ChIP-Seq_NB4_Human	1.18343416
48	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.18150900
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.16517626
50	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14546905
51	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.14484438
52	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13053343
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12327723
54	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.11794397
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10671486
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10591536
57	AR_20517297_ChIP-Seq_VCAP_Human	1.09858028
58	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08651873
59	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.06363002
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05671917
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05468684
62	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.05389227
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.04143858
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03477949
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02600971
66	SCL_19346495_ChIP-Seq_HPC-7_Human	1.01799460
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99837747
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99819178
69	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.99800279
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98547126
71	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.97209797
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97093516
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96068812
74	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.95714946
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95663159
76	ZNF274_21170338_ChIP-Seq_K562_Hela	0.94261272
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93941093
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93941093
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.91945521
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.91841229
81	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91059744
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90906653
83	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.90903951
84	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.89439801
85	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.88945234
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87044149
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.86352053
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.85207822
89	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.84915310
90	PHF8_20622853_ChIP-Seq_HELA_Human	0.84315784
91	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.83770240
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.83433144
93	NCOR_22424771_ChIP-Seq_293T_Human	0.83114467
94	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.82867689
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.82616751
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82600614
97	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.82159017
98	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.82159017
99	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.82159017
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.81875593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.43854413
2	MP0003878_abnormal_ear_physiology	4.15462965
3	MP0005377_hearing/vestibular/ear_phenot	4.15462965
4	MP0008995_early_reproductive_senescence	3.39368147
5	MP0009379_abnormal_foot_pigmentation	3.34304744
6	MP0003186_abnormal_redox_activity	3.27406872
7	MP0001529_abnormal_vocalization	3.15297875
8	MP0005171_absent_coat_pigmentation	3.04841469
9	MP0000372_irregular_coat_pigmentation	2.84339632
10	MP0002837_dystrophic_cardiac_calcinosis	2.68503051
11	MP0009697_abnormal_copulation	2.60097441
12	MP0001984_abnormal_olfaction	2.43826501
13	MP0005645_abnormal_hypothalamus_physiol	2.32270334
14	MP0003806_abnormal_nucleotide_metabolis	2.22758561
15	MP0003656_abnormal_erythrocyte_physiolo	2.17109060
16	MP0001485_abnormal_pinna_reflex	2.15020503
17	MP0003786_premature_aging	2.14980966
18	MP0002163_abnormal_gland_morphology	2.11439274
19	MP0005646_abnormal_pituitary_gland	2.11185203
20	MP0000516_abnormal_urinary_system	2.02799957
21	MP0005367_renal/urinary_system_phenotyp	2.02799957
22	MP0001835_abnormal_antigen_presentation	2.01659907
23	MP0006036_abnormal_mitochondrial_physio	2.01396453
24	MP0005503_abnormal_tendon_morphology	1.96021551
25	MP0004145_abnormal_muscle_electrophysio	1.92252029
26	MP0003646_muscle_fatigue	1.86610476
27	MP0008872_abnormal_physiological_respon	1.80236615
28	MP0008789_abnormal_olfactory_epithelium	1.76613746
29	MP0005636_abnormal_mineral_homeostasis	1.68616116
30	MP0004957_abnormal_blastocyst_morpholog	1.64923827
31	MP0010386_abnormal_urinary_bladder	1.60780194
32	MP0001756_abnormal_urination	1.59062065
33	MP0003195_calcinosis	1.57485483
34	MP0009764_decreased_sensitivity_to	1.48802384
35	MP0001919_abnormal_reproductive_system	1.40983290
36	MP0005332_abnormal_amino_acid	1.35591810
37	MP0001764_abnormal_homeostasis	1.32706211
38	MP0004019_abnormal_vitamin_homeostasis	1.30896116
39	MP0009333_abnormal_splenocyte_physiolog	1.30802595
40	MP0001879_abnormal_lymphatic_vessel	1.21846353
41	MP0004142_abnormal_muscle_tone	1.20635132
42	MP0003137_abnormal_impulse_conducting	1.20109467
43	MP0009785_altered_susceptibility_to	1.19551454
44	MP0008875_abnormal_xenobiotic_pharmacok	1.16546266
45	MP0005499_abnormal_olfactory_system	1.12423686
46	MP0005394_taste/olfaction_phenotype	1.12423686
47	MP0005360_urolithiasis	1.11159093
48	MP0005410_abnormal_fertilization	1.11017660
49	MP0005379_endocrine/exocrine_gland_phen	1.09077120
50	MP0001661_extended_life_span	1.07709021
51	MP0002735_abnormal_chemical_nociception	1.07622614
52	MP0003724_increased_susceptibility_to	1.01947587
53	MP0004742_abnormal_vestibular_system	0.96814516
54	MP0001765_abnormal_ion_homeostasis	0.96595587
55	MP0002234_abnormal_pharynx_morphology	0.96468823
56	MP0005253_abnormal_eye_physiology	0.95632666
57	MP0001440_abnormal_grooming_behavior	0.94569016
58	MP0002108_abnormal_muscle_morphology	0.93796641
59	MP0005075_abnormal_melanosome_morpholog	0.93218105
60	MP0000371_diluted_coat_color	0.92120379
61	MP0005551_abnormal_eye_electrophysiolog	0.91487390
62	MP0006072_abnormal_retinal_apoptosis	0.90368335
63	MP0004215_abnormal_myocardial_fiber	0.90253711
64	MP0001986_abnormal_taste_sensitivity	0.89982604
65	MP0001800_abnormal_humoral_immune	0.88961011
66	MP0002102_abnormal_ear_morphology	0.88756113
67	MP0003123_paternal_imprinting	0.86218828
68	MP0009643_abnormal_urine_homeostasis	0.84757172
69	MP0000685_abnormal_immune_system	0.84446543
70	MP0005397_hematopoietic_system_phenotyp	0.83467454
71	MP0001545_abnormal_hematopoietic_system	0.83467454
72	MP0004381_abnormal_hair_follicle	0.80417901
73	MP0005389_reproductive_system_phenotype	0.79531106
74	MP0000750_abnormal_muscle_regeneration	0.79010724
75	MP0001968_abnormal_touch/_nociception	0.77467770
76	MP0005671_abnormal_response_to	0.76335325
77	MP0001486_abnormal_startle_reflex	0.76303590
78	MP0001542_abnormal_bone_strength	0.73567699
79	MP0002277_abnormal_respiratory_mucosa	0.72545199
80	MP0001970_abnormal_pain_threshold	0.72277863
81	MP0004858_abnormal_nervous_system	0.71559659
82	MP0003866_abnormal_defecation	0.71288638
83	MP0002452_abnormal_antigen_presenting	0.69372803
84	MP0001845_abnormal_inflammatory_respons	0.69346143
85	MP0005000_abnormal_immune_tolerance	0.69162694
86	MP0005319_abnormal_enzyme/_coenzyme	0.68068243
87	MP0005083_abnormal_biliary_tract	0.67781381
88	MP0002723_abnormal_immune_serum	0.66918812
89	MP0001119_abnormal_female_reproductive	0.66030959
90	MP0000639_abnormal_adrenal_gland	0.65734332
91	MP0003959_abnormal_lean_body	0.65111982
92	MP0003718_maternal_effect	0.63859834
93	MP0008058_abnormal_DNA_repair	0.63424000
94	MP0005387_immune_system_phenotype	0.62977415
95	MP0001790_abnormal_immune_system	0.62977415
96	MP0005647_abnormal_sex_gland	0.62465851
97	MP0006292_abnormal_olfactory_placode	0.60904627
98	MP0006035_abnormal_mitochondrial_morpho	0.60562439
99	MP0009765_abnormal_xenobiotic_induced	0.60156412
100	MP0008877_abnormal_DNA_methylation	0.59960964

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	6.28944880
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	6.28086083
3	3-Methylglutaconic aciduria (HP:0003535)	5.38897719
4	Acute necrotizing encephalopathy (HP:0006965)	5.33131523
5	Progressive macrocephaly (HP:0004481)	5.32574939
6	Mitochondrial inheritance (HP:0001427)	4.86923332
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.74586098
8	Acute encephalopathy (HP:0006846)	4.58388031
9	Hepatocellular necrosis (HP:0001404)	4.38387178
10	Increased CSF lactate (HP:0002490)	4.31237205
11	Exertional dyspnea (HP:0002875)	3.95822033
12	Increased hepatocellular lipid droplets (HP:0006565)	3.85594966
13	Hypothermia (HP:0002045)	3.82674686
14	Hepatic necrosis (HP:0002605)	3.79263452
15	Renal Fanconi syndrome (HP:0001994)	3.77093609
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.55123525
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.55123525
18	Lipid accumulation in hepatocytes (HP:0006561)	3.29702472
19	Stillbirth (HP:0003826)	3.21344881
20	Hypochromic microcytic anemia (HP:0004840)	3.20488870
21	Increased intramyocellular lipid droplets (HP:0012240)	3.14880313
22	Cerebral edema (HP:0002181)	3.12941837
23	Pallor (HP:0000980)	3.09485736
24	Septate vagina (HP:0001153)	3.02898493
25	Woolly hair (HP:0002224)	3.00054535
26	Hypoplastic left heart (HP:0004383)	2.94293601
27	Rectovaginal fistula (HP:0000143)	2.69825199
28	Rectal fistula (HP:0100590)	2.69825199
29	Leukodystrophy (HP:0002415)	2.65717826
30	Increased muscle lipid content (HP:0009058)	2.63488837
31	Respiratory failure (HP:0002878)	2.52792327
32	Microcytic anemia (HP:0001935)	2.52725134
33	Lactic acidosis (HP:0003128)	2.51220744
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50853015
35	Conjunctival hamartoma (HP:0100780)	2.50367308
36	Optic disc pallor (HP:0000543)	2.50001113
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41665979
38	Hypoplastic heart (HP:0001961)	2.39881877
39	Scotoma (HP:0000575)	2.37972758
40	Intestinal fistula (HP:0100819)	2.34338489
41	Abnormal number of erythroid precursors (HP:0012131)	2.30198542
42	Increased serum lactate (HP:0002151)	2.26292572
43	Stomach cancer (HP:0012126)	2.25542316
44	Abnormality of renal resorption (HP:0011038)	2.22035731
45	Obstructive lung disease (HP:0006536)	2.14722511
46	Chronic obstructive pulmonary disease (HP:0006510)	2.14722511
47	Vaginal fistula (HP:0004320)	2.14152295
48	Generalized aminoaciduria (HP:0002909)	2.13294916
49	Midline defect of the nose (HP:0004122)	2.12188443
50	Hamartoma of the eye (HP:0010568)	2.08751973
51	Central scotoma (HP:0000603)	2.07520082
52	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03999108
53	Microretrognathia (HP:0000308)	2.02737323
54	Seborrheic dermatitis (HP:0001051)	2.02552342
55	Abnormal hemoglobin (HP:0011902)	10.9513345
56	Spastic paraparesis (HP:0002313)	1.98856338
57	Toxemia of pregnancy (HP:0100603)	1.93014346
58	Cleft eyelid (HP:0000625)	1.89567499
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89130804
60	Hyperthyroidism (HP:0000836)	1.87138330
61	Glycosuria (HP:0003076)	1.86515875
62	Abnormality of urine glucose concentration (HP:0011016)	1.86515875
63	Exercise intolerance (HP:0003546)	1.85631395
64	Hypochromic anemia (HP:0001931)	1.84319743
65	Aplastic anemia (HP:0001915)	1.84293134
66	Abnormality of the tricuspid valve (HP:0001702)	1.84087877
67	Absent thumb (HP:0009777)	1.83355501
68	Gastrointestinal infarctions (HP:0005244)	1.82143230
69	Bilateral microphthalmos (HP:0007633)	1.81977556
70	X-linked dominant inheritance (HP:0001423)	1.81939486
71	Anorexia (HP:0002039)	1.81823851
72	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79453558
73	Hypoplasia of the fovea (HP:0007750)	1.79453558
74	Meckel diverticulum (HP:0002245)	1.78827851
75	Respiratory difficulties (HP:0002880)	1.78500145
76	Hypertensive crisis (HP:0100735)	1.77197997
77	Abnormality of B cell number (HP:0010975)	1.77162700
78	Ileus (HP:0002595)	1.76461978
79	Submucous cleft hard palate (HP:0000176)	1.75819541
80	Entropion (HP:0000621)	1.74978759
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.74655430
82	Reticulocytosis (HP:0001923)	1.72906863
83	Lethargy (HP:0001254)	1.67746075
84	Delayed CNS myelination (HP:0002188)	1.67545516
85	Anomalous pulmonary venous return (HP:0010772)	1.67529808
86	Poikilocytosis (HP:0004447)	1.66509764
87	Macrocytic anemia (HP:0001972)	1.65541385
88	Conjunctival telangiectasia (HP:0000524)	1.64036192
89	Abnormality of the ileum (HP:0001549)	1.63328044
90	Gonadal dysgenesis (HP:0000133)	1.63313436
91	Redundant skin (HP:0001582)	1.62905996
92	Meningioma (HP:0002858)	1.62504994
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.61430840
94	Hydroureter (HP:0000072)	1.60765851
95	Constricted visual fields (HP:0001133)	1.58803300
96	Diplopia (HP:0000651)	1.58284365
97	Abnormality of binocular vision (HP:0011514)	1.58284365
98	Abnormality of reticulocytes (HP:0004312)	1.58017700
99	Female pseudohermaphroditism (HP:0010458)	1.56474571
100	Chromsome breakage (HP:0040012)	1.54894452

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	5.24234999
2	BMPR2	4.39307506
3	MAP3K12	4.33512935
4	RIPK4	3.23027660
5	CDC7	2.85984127
6	TESK1	2.82864409
7	ILK	2.51176212
8	MYLK	2.46061201
9	ZAK	2.29894106
10	EIF2AK3	2.29476250
11	TNK2	2.10219891
12	CAMKK2	1.98140931
13	SRPK1	1.96069966
14	LIMK1	1.85333974
15	NEK1	1.82477779
16	MAP3K4	1.76038434
17	TLK1	1.71220918
18	MATK	1.57023795
19	FRK	1.55972615
20	MAP3K2	1.51558799
21	MAP4K2	1.48940412
22	CDK19	1.44307647
23	DAPK3	1.36727499
24	PKN1	1.32229384
25	ABL2	1.31996290
26	GRK6	1.27886719
27	WNK4	1.27800621
28	CDK8	1.25435443
29	PHKG2	1.24928072
30	PHKG1	1.24928072
31	BTK	1.23089084
32	CLK1	1.19375474
33	TXK	1.15696472
34	INSRR	1.09322347
35	MAP2K4	1.04710970
36	DYRK1B	1.01745768
37	LYN	0.98051282
38	CAMK1D	0.97471161
39	MAP2K3	0.95585341
40	PIK3CG	0.89203868
41	NTRK3	0.88604948
42	GRK1	0.88234284
43	TRPM7	0.83612082
44	VRK2	0.83542028
45	PLK4	0.82735204
46	SYK	0.81968906
47	CDK3	0.81867316
48	AURKB	0.76080916
49	CHEK2	0.75107737
50	CAMK1	0.74833187
51	MAP4K1	0.74550269
52	NME2	0.74535175
53	IKBKB	0.73400032
54	OXSR1	0.72328803
55	PTK2B	0.69127204
56	WNK1	0.69022798
57	RPS6KA5	0.66817610
58	MAPKAPK5	0.66125619
59	TEC	0.65069703
60	NUAK1	0.63028452
61	CSF1R	0.62812471
62	LCK	0.62515013
63	OBSCN	0.60330452
64	PIM1	0.59398959
65	PRKG1	0.57199927
66	MARK3	0.56590147
67	MAP3K6	0.55473798
68	KIT	0.55097687
69	ADRBK2	0.54754631
70	EGFR	0.54394452
71	MAP2K6	0.52059326
72	PRKAA2	0.51415383
73	RPS6KA4	0.50283606
74	CAMK2A	0.50259568
75	DAPK1	0.46704463
76	ITK	0.46413193
77	TAF1	0.45264936
78	CAMKK1	0.44670330
79	PRKCD	0.44075410
80	PAK4	0.43968969
81	PRKACA	0.43127002
82	JAK3	0.43062773
83	CASK	0.42334650
84	ATR	0.41401211
85	MKNK2	0.40964955
86	ERBB2	0.39564820
87	BMX	0.38540982
88	WNK3	0.36507402
89	CAMK4	0.36284526
90	CSNK2A1	0.35805177
91	MKNK1	0.34878271
92	BRD4	0.33504556
93	MST4	0.33501410
94	CSNK2A2	0.32138818
95	RPS6KA6	0.28058149
96	FGFR1	0.27889884
97	VRK1	0.27816676
98	ROCK1	0.27195823
99	BLK	0.26215780
100	PRKAA1	0.25858823

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	6.06427389
2	Parkinsons disease_Homo sapiens_hsa05012	5.09894028
3	Ribosome_Homo sapiens_hsa03010	4.28591240
4	Alzheimers disease_Homo sapiens_hsa05010	3.84019892
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.58520355
6	Protein export_Homo sapiens_hsa03060	3.50349032
7	Huntingtons disease_Homo sapiens_hsa05016	3.30977264
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.91340864
9	Proteasome_Homo sapiens_hsa03050	2.89259725
10	Asthma_Homo sapiens_hsa05310	2.62983778
11	Mineral absorption_Homo sapiens_hsa04978	2.03037831
12	Malaria_Homo sapiens_hsa05144	1.89379106
13	Allograft rejection_Homo sapiens_hsa05330	1.78577879
14	Homologous recombination_Homo sapiens_hsa03440	1.74920436
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74653741
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.69783005
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.62620967
18	Spliceosome_Homo sapiens_hsa03040	1.60451826
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.34774207
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33150362
21	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.27235973
22	DNA replication_Homo sapiens_hsa03030	1.25383810
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.19802681
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.18944952
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16972523
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15481442
27	Mismatch repair_Homo sapiens_hsa03430	1.15153438
28	Regulation of autophagy_Homo sapiens_hsa04140	1.12406070
29	RNA polymerase_Homo sapiens_hsa03020	1.10732103
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10197294
31	Sulfur metabolism_Homo sapiens_hsa00920	1.09106739
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92822142
33	Leishmaniasis_Homo sapiens_hsa05140	0.92727205
34	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91860805
35	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90452895
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.89921630
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86206740
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.80986288
39	One carbon pool by folate_Homo sapiens_hsa00670	0.79401946
40	African trypanosomiasis_Homo sapiens_hsa05143	0.77314189
41	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74887480
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71761229
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.71731588
44	RNA degradation_Homo sapiens_hsa03018	0.71666576
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.66851920
46	Glutathione metabolism_Homo sapiens_hsa00480	0.65798798
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64003211
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63721367
49	Caffeine metabolism_Homo sapiens_hsa00232	0.59767302
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58990183
51	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.58404102
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55851915
53	Sulfur relay system_Homo sapiens_hsa04122	0.54009922
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53394011
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51902888
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.50265525
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49019999
58	Olfactory transduction_Homo sapiens_hsa04740	0.48821527
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48465750
60	Phototransduction_Homo sapiens_hsa04744	0.46333057
61	Taste transduction_Homo sapiens_hsa04742	0.46295286
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.42637131
63	Purine metabolism_Homo sapiens_hsa00230	0.42633079
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41615785
65	Nicotine addiction_Homo sapiens_hsa05033	0.41454123
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41083465
67	Metabolic pathways_Homo sapiens_hsa01100	0.40178365
68	RNA transport_Homo sapiens_hsa03013	0.39603747
69	Basal transcription factors_Homo sapiens_hsa03022	0.36773312
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36169821
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36003620
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35260892
73	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.34732081
74	Toxoplasmosis_Homo sapiens_hsa05145	0.33995412
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33909284
76	Viral myocarditis_Homo sapiens_hsa05416	0.30814111
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27374208
78	VEGF signaling pathway_Homo sapiens_hsa04370	0.23067017
79	Influenza A_Homo sapiens_hsa05164	0.22952405
80	Bladder cancer_Homo sapiens_hsa05219	0.22191339
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.22149656
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.22032000
83	Base excision repair_Homo sapiens_hsa03410	0.20879258
84	Nitrogen metabolism_Homo sapiens_hsa00910	0.19111696
85	Morphine addiction_Homo sapiens_hsa05032	0.18052667
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.17758215
87	Tuberculosis_Homo sapiens_hsa05152	0.17533949
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.16953601
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.16908166
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.16790571
91	GABAergic synapse_Homo sapiens_hsa04727	0.16488985
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.15733743
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.14989834
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.13922111
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.13547094
96	Phagosome_Homo sapiens_hsa04145	0.13349363
97	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.12173315
98	Oocyte meiosis_Homo sapiens_hsa04114	0.10927451
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.09177210
100	Amphetamine addiction_Homo sapiens_hsa05031	0.08415359

HBZP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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