HCAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.35570877
2regulation of sequestering of triglyceride (GO:0010889)7.48323019
3triglyceride catabolic process (GO:0019433)7.24246061
4white fat cell differentiation (GO:0050872)6.98637319
5acylglycerol catabolic process (GO:0046464)6.57738149
6neutral lipid catabolic process (GO:0046461)6.57738149
7valine metabolic process (GO:0006573)6.50776746
8brown fat cell differentiation (GO:0050873)6.44562577
9biotin metabolic process (GO:0006768)6.07939065
10behavioral response to nicotine (GO:0035095)5.52776726
11lipid particle organization (GO:0034389)5.08951888
12regulation of cholesterol storage (GO:0010885)5.03254199
13fatty acid transmembrane transport (GO:1902001)4.92813886
14positive regulation of fatty acid oxidation (GO:0046321)4.92028795
15negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.90315771
16protein heterotrimerization (GO:0070208)4.84162884
17glycerolipid catabolic process (GO:0046503)4.82164694
18triglyceride biosynthetic process (GO:0019432)4.81389413
19positive regulation of fatty acid beta-oxidation (GO:0032000)4.63746896
20L-fucose catabolic process (GO:0042355)4.60898938
21fucose catabolic process (GO:0019317)4.60898938
22L-fucose metabolic process (GO:0042354)4.60898938
23neutral lipid biosynthetic process (GO:0046460)4.59662342
24acylglycerol biosynthetic process (GO:0046463)4.59662342
25carnitine shuttle (GO:0006853)4.56838762
26fatty acid beta-oxidation (GO:0006635)4.40542538
27retina vasculature morphogenesis in camera-type eye (GO:0061299)4.38049102
28branched-chain amino acid metabolic process (GO:0009081)4.24997389
29response to dietary excess (GO:0002021)4.20647995
30lipid storage (GO:0019915)4.14990039
31negative regulation of protein autophosphorylation (GO:0031953)4.13062227
32regulation of glycogen (starch) synthase activity (GO:2000465)4.00755029
33branched-chain amino acid catabolic process (GO:0009083)4.00098100
34regulation of fatty acid oxidation (GO:0046320)3.98739580
35cellular ketone body metabolic process (GO:0046950)3.95710788
36fatty acid oxidation (GO:0019395)3.95432270
37DNA deamination (GO:0045006)3.93564942
38tricarboxylic acid metabolic process (GO:0072350)3.93113089
39response to pheromone (GO:0019236)3.87777015
40lipid oxidation (GO:0034440)3.87258286
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.85268351
42indolalkylamine metabolic process (GO:0006586)3.84830075
43fatty-acyl-CoA biosynthetic process (GO:0046949)3.84755204
44positive regulation of cellular response to insulin stimulus (GO:1900078)3.84648111
45tryptophan catabolic process (GO:0006569)3.82484351
46indole-containing compound catabolic process (GO:0042436)3.82484351
47indolalkylamine catabolic process (GO:0046218)3.82484351
48thioester biosynthetic process (GO:0035384)3.82361164
49acyl-CoA biosynthetic process (GO:0071616)3.82361164
50triglyceride metabolic process (GO:0006641)3.80257387
51cellular response to lithium ion (GO:0071285)3.76956646
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75467192
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.73206512
54fatty acid catabolic process (GO:0009062)3.73166732
55positive regulation of fatty acid metabolic process (GO:0045923)3.67944482
56fatty acid homeostasis (GO:0055089)3.63858205
57carnitine transmembrane transport (GO:1902603)3.63745714
58epoxygenase P450 pathway (GO:0019373)3.63053712
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.61739527
60kynurenine metabolic process (GO:0070189)3.61386930
61acylglycerol metabolic process (GO:0006639)3.59652784
62ketone body metabolic process (GO:1902224)3.58847706
63fatty-acyl-CoA metabolic process (GO:0035337)3.58709453
64regulation of fatty acid beta-oxidation (GO:0031998)3.55914402
65neutral lipid metabolic process (GO:0006638)3.54066649
66tryptophan metabolic process (GO:0006568)3.50815857
67platelet dense granule organization (GO:0060155)3.49497833
68regulation of macrophage derived foam cell differentiation (GO:0010743)3.47127009
69cellular response to vitamin (GO:0071295)3.46388502
70regulation of cAMP-dependent protein kinase activity (GO:2000479)3.44431087
71NADH metabolic process (GO:0006734)3.43410833
72transcytosis (GO:0045056)3.40655765
73detection of light stimulus involved in sensory perception (GO:0050962)3.39542883
74detection of light stimulus involved in visual perception (GO:0050908)3.39542883
75negative regulation of telomere maintenance (GO:0032205)3.38374120
76positive regulation of glucose import (GO:0046326)3.38212507
77alpha-linolenic acid metabolic process (GO:0036109)3.37529315
78negative regulation of lipid storage (GO:0010888)3.37126853
79carnitine transport (GO:0015879)3.35932283
80amino-acid betaine transport (GO:0015838)3.35932283
81piRNA metabolic process (GO:0034587)3.32471187
82positive regulation of glomerulus development (GO:0090193)3.31273782
83positive regulation of lipid catabolic process (GO:0050996)3.30574225
84coenzyme A biosynthetic process (GO:0015937)3.29153341
85positive regulation of histone deacetylation (GO:0031065)3.27689440
86plasma lipoprotein particle clearance (GO:0034381)3.27574843
87water-soluble vitamin biosynthetic process (GO:0042364)3.26400407
88axoneme assembly (GO:0035082)3.23095950
89neural tube formation (GO:0001841)3.22759116
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22747631
91negative regulation of gluconeogenesis (GO:0045721)3.22432358
92kidney morphogenesis (GO:0060993)3.20489628
93growth hormone receptor signaling pathway (GO:0060396)3.19428942
94oxaloacetate metabolic process (GO:0006107)3.19366074
95protein polyglutamylation (GO:0018095)3.18251239
96negative regulation of granulocyte differentiation (GO:0030853)3.18150125
97epithelial cilium movement (GO:0003351)3.17856169
98pentose-phosphate shunt (GO:0006098)3.17598466
99negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.16655460
100endothelial cell chemotaxis (GO:0035767)3.16618906
101negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.16362663
102intracellular lipid transport (GO:0032365)3.15039104
103response to lipoprotein particle (GO:0055094)3.13587843
104complement activation, alternative pathway (GO:0006957)3.12753282
105acetyl-CoA metabolic process (GO:0006084)3.11284996
106cornea development in camera-type eye (GO:0061303)3.11226665
107positive regulation of glycogen biosynthetic process (GO:0045725)3.09006658
108regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.06958145
109NADPH regeneration (GO:0006740)3.06379777
110respiratory chain complex IV assembly (GO:0008535)3.05919443
111negative regulation of phagocytosis (GO:0050765)3.04050255
112nephron tubule morphogenesis (GO:0072078)3.03714907
113nephron epithelium morphogenesis (GO:0072088)3.03714907
114regulation of glucose import in response to insulin stimulus (GO:2001273)3.03658908
115regulation of triglyceride biosynthetic process (GO:0010866)3.00679749
116cellular response to epinephrine stimulus (GO:0071872)3.00499292
117negative regulation of metanephros development (GO:0072217)2.97698653
118protein complex biogenesis (GO:0070271)2.97573221
119behavioral response to ethanol (GO:0048149)2.96510327
120succinate metabolic process (GO:0006105)2.94857436
121positive regulation of lipid storage (GO:0010884)2.93915546
122Golgi transport vesicle coating (GO:0048200)2.93598110
123COPI coating of Golgi vesicle (GO:0048205)2.93598110
124indole-containing compound metabolic process (GO:0042430)2.92852859
125regulation of triglyceride catabolic process (GO:0010896)2.92482979
126protein-cofactor linkage (GO:0018065)2.90837208
127positive regulation of glycolytic process (GO:0045821)2.90818240
128tricarboxylic acid cycle (GO:0006099)2.90134211
129regulation of triglyceride metabolic process (GO:0090207)2.89947800
130positive regulation of cholesterol efflux (GO:0010875)2.89220953
131ovulation from ovarian follicle (GO:0001542)2.88175662
132positive regulation of insulin receptor signaling pathway (GO:0046628)2.87876768
133positive regulation of glucose transport (GO:0010828)2.87757946
134iron ion import (GO:0097286)2.87286758
135cellular response to growth hormone stimulus (GO:0071378)2.86261745
136neuronal action potential (GO:0019228)2.85643160
137cilium morphogenesis (GO:0060271)2.85441894
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84547764
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.84547764
140NADH dehydrogenase complex assembly (GO:0010257)2.84547764
141preassembly of GPI anchor in ER membrane (GO:0016254)2.84373502
142nonmotile primary cilium assembly (GO:0035058)2.80619611
143sulfation (GO:0051923)2.80100563
144regulation of action potential (GO:0098900)2.78571453
145regulation of hippo signaling (GO:0035330)2.77739033
146cellular biogenic amine catabolic process (GO:0042402)2.76577573
147amine catabolic process (GO:0009310)2.76577573
148mitochondrial respiratory chain complex assembly (GO:0033108)2.74121148
149negative regulation of mast cell activation (GO:0033004)2.73244158
150regulation of cilium movement (GO:0003352)2.72897446
151gamma-aminobutyric acid transport (GO:0015812)2.72252323
152regulation of hexokinase activity (GO:1903299)2.71470559
153regulation of glucokinase activity (GO:0033131)2.71470559
154photoreceptor cell maintenance (GO:0045494)2.71275722
155cytochrome complex assembly (GO:0017004)2.70416825
156protein localization to cilium (GO:0061512)2.70153188
157cilium movement (GO:0003341)2.70125402
158protein K11-linked deubiquitination (GO:0035871)2.69292827
159mannosylation (GO:0097502)2.68318594
160reflex (GO:0060004)2.68087610
161dopamine transport (GO:0015872)2.63934958
162rhodopsin mediated signaling pathway (GO:0016056)2.63415942
163DNA methylation involved in gamete generation (GO:0043046)2.63052367
164retinal cone cell development (GO:0046549)2.62370283
165regulation of rhodopsin mediated signaling pathway (GO:0022400)2.62226316
166ubiquinone biosynthetic process (GO:0006744)2.61484952
167multicellular organism reproduction (GO:0032504)2.56393329
168cilium organization (GO:0044782)2.55897079
169auditory receptor cell stereocilium organization (GO:0060088)2.52231092
170photoreceptor cell development (GO:0042461)2.51888554
171cilium or flagellum-dependent cell motility (GO:0001539)2.51802090
172somite development (GO:0061053)2.51569950
173primary amino compound metabolic process (GO:1901160)2.51168082
174embryonic epithelial tube formation (GO:0001838)2.50233460
175G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48906666
176regulation of telomere maintenance (GO:0032204)2.48458978
177synaptic transmission, cholinergic (GO:0007271)2.47864731
178ubiquinone metabolic process (GO:0006743)2.47145344
179cilium assembly (GO:0042384)2.47050981
180DNA double-strand break processing (GO:0000729)2.47045520
181negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45628458
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43066258
183rRNA catabolic process (GO:0016075)2.41333174
184positive regulation of fatty acid transport (GO:2000193)2.39641127
185reciprocal meiotic recombination (GO:0007131)2.39190799
186reciprocal DNA recombination (GO:0035825)2.39190799
187regulation of nuclear cell cycle DNA replication (GO:0033262)2.39128311
188positive regulation of oligodendrocyte differentiation (GO:0048714)2.38062446
189S-adenosylmethionine metabolic process (GO:0046500)2.37970959
190signal peptide processing (GO:0006465)2.37726135
191startle response (GO:0001964)2.37210370
192phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37133171
193aromatic amino acid family catabolic process (GO:0009074)2.36744395
194fucosylation (GO:0036065)2.36201784
195benzene-containing compound metabolic process (GO:0042537)2.35161644
1963-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35021912
197purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35021912
198NAD biosynthetic process (GO:0009435)2.34318184
199negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33265667
200negative regulation of reactive oxygen species metabolic process (GO:2000378)2.32981115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.69299647
2CLOCK_20551151_ChIP-Seq_293T_Human4.42200393
3ZNF274_21170338_ChIP-Seq_K562_Hela4.27704918
4VDR_22108803_ChIP-Seq_LS180_Human3.41065087
5GBX2_23144817_ChIP-Seq_PC3_Human3.05208548
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.89837098
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83912675
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75441160
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51536603
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.51280513
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.48533308
12IGF1R_20145208_ChIP-Seq_DFB_Human2.45525575
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.43115786
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.41172816
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38833532
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33487094
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31725274
18EZH2_22144423_ChIP-Seq_EOC_Human2.29712740
19PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.26793548
20ER_23166858_ChIP-Seq_MCF-7_Human2.18867941
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17766823
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17614377
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17163141
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12582678
25GATA1_22025678_ChIP-Seq_K562_Human2.07631711
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.07521124
27TAF15_26573619_Chip-Seq_HEK293_Human2.03632356
28FUS_26573619_Chip-Seq_HEK293_Human2.02734922
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse12.4331489
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99784604
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99261678
32EWS_26573619_Chip-Seq_HEK293_Human1.98727425
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93397060
34P300_19829295_ChIP-Seq_ESCs_Human1.89486231
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88901894
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84670013
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.81036119
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78292081
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77345997
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.76158517
41PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.72770079
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71306342
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68387896
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66766330
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62166796
46TP53_22573176_ChIP-Seq_HFKS_Human1.60184046
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60124428
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58613301
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56228156
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.55524263
51STAT3_23295773_ChIP-Seq_U87_Human1.54635895
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52114069
53AR_25329375_ChIP-Seq_VCAP_Human1.49712438
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47788679
55CBP_20019798_ChIP-Seq_JUKART_Human1.47788679
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47053541
57SMAD4_21799915_ChIP-Seq_A2780_Human1.46224664
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45120919
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44984403
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43889863
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42859156
62TCF4_23295773_ChIP-Seq_U87_Human1.40192167
63IRF1_19129219_ChIP-ChIP_H3396_Human1.39752609
64REST_21632747_ChIP-Seq_MESCs_Mouse1.39617881
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39040583
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.38597316
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.38090188
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.38090188
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36781971
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35612708
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.35471255
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35471255
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.35326612
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34156671
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34156671
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34071801
77TCF4_22108803_ChIP-Seq_LS180_Human1.32277085
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31983062
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.31849569
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.31579956
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.31033822
82HOXB7_26014856_ChIP-Seq_BT474_Human1.29812690
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.28930351
84NANOG_19829295_ChIP-Seq_ESCs_Human1.28726239
85SOX2_19829295_ChIP-Seq_ESCs_Human1.28726239
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28140226
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27990120
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.27745924
89ZNF263_19887448_ChIP-Seq_K562_Human1.26780320
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24695432
91AR_20517297_ChIP-Seq_VCAP_Human1.24665302
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24030917
93MYC_18940864_ChIP-ChIP_HL60_Human1.23279974
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21940303
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21530212
96RUNX2_22187159_ChIP-Seq_PCA_Human1.19372114
97RNF2_27304074_Chip-Seq_NSC_Mouse1.18907451
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18477668
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17608761
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17392779
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.17129037
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16912346
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.16619951
104NCOR_22424771_ChIP-Seq_293T_Human1.15699144
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15433612
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13503412
107GATA1_19941826_ChIP-Seq_K562_Human1.13328789
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.13174371
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12781295
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.12394957
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12071938
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11324946
113EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11324946
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10597348
115AR_21572438_ChIP-Seq_LNCaP_Human1.10527778
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.10008258
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.09543908
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09459568
119CJUN_26792858_Chip-Seq_BT549_Human1.08807296
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.07343675
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06669399
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06271430
123SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04756428
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.04623307
125AHR_22903824_ChIP-Seq_MCF-7_Human1.03453406
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.03357218
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03310901
128RXR_22108803_ChIP-Seq_LS180_Human1.01609302
129FOXA2_19822575_ChIP-Seq_HepG2_Human1.01189896
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01148615
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00267668
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00069643
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99904165
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99604479
135CDX2_22108803_ChIP-Seq_LS180_Human0.99027153
136ERA_21632823_ChIP-Seq_H3396_Human0.99003469
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98735562
138MYC_19829295_ChIP-Seq_ESCs_Human0.97671400
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.97651471
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96998099
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.96927247
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96593798
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96210382
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95989259
145P53_22387025_ChIP-Seq_ESCs_Mouse0.95706818
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95129488
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94987062
148SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93927307
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93684584
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93667788
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93142080
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92388125
153VDR_24787735_ChIP-Seq_THP-1_Human0.92204526
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91768425
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91605795
156MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91244283
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89882692
158KDM2B_26808549_Chip-Seq_K562_Human0.89687603
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87152622
160EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87124961
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86789555
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86789555
163EED_16625203_ChIP-ChIP_MESCs_Mouse0.86402713
164SOX2_20726797_ChIP-Seq_SW620_Human0.85361888
165DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84065136
166SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83752030
167LXR_22292898_ChIP-Seq_THP-1_Human0.82030054
168PIAS1_25552417_ChIP-Seq_VCAP_Human0.81920838
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.81607139
170SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81166979
171ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80620004
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80570950
173TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78385613
174PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75498076
175GATA2_19941826_ChIP-Seq_K562_Human0.74825718
176ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74819331
177SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74258280
178BCAT_22108803_ChIP-Seq_LS180_Human0.74133317
179KLF4_19829295_ChIP-Seq_ESCs_Human0.73758348
180P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73720732
181EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73689788
182Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73116846
183ISL1_27105846_Chip-Seq_CPCs_Mouse0.72058116
184RUNX1_27514584_Chip-Seq_MCF-7_Human0.71792755
185SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.71226428
186KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71056804
187JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70824579
188SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70557106
189GATA3_24758297_ChIP-Seq_MCF-7_Human0.70236330
190GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69766987
191SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69735129
192RACK7_27058665_Chip-Seq_MCF-7_Human0.69703325
193AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68952404
194DROSHA_22980978_ChIP-Seq_HELA_Human0.68496450
195SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68321535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.57669605
2MP0005666_abnormal_adipose_tissue5.20345818
3MP0004185_abnormal_adipocyte_glucose5.02847390
4MP0004130_abnormal_muscle_cell4.81467702
5MP0005375_adipose_tissue_phenotype4.12948752
6MP0000013_abnormal_adipose_tissue4.03129032
7MP0008438_abnormal_cutaneous_collagen3.92964711
8MP0000003_abnormal_adipose_tissue3.35478334
9MP0002837_dystrophic_cardiac_calcinosis3.17506283
10MP0002971_abnormal_brown_adipose2.83407347
11MP0002102_abnormal_ear_morphology2.56437576
12MP0005551_abnormal_eye_electrophysiolog2.55068494
13MP0001968_abnormal_touch/_nociception2.50884325
14MP0008877_abnormal_DNA_methylation2.49834952
15MP0005275_abnormal_skin_tensile2.49370249
16MP0010329_abnormal_lipoprotein_level2.44224069
17MP0004272_abnormal_basement_membrane2.29713235
18MP0009115_abnormal_fat_cell2.29182553
19MP0002876_abnormal_thyroid_physiology2.25680565
20MP0005334_abnormal_fat_pad2.24817388
21MP0005646_abnormal_pituitary_gland2.24779395
22MP0002736_abnormal_nociception_after2.23116069
23MP0001661_extended_life_span2.21683995
24MP0003646_muscle_fatigue2.17659618
25MP0008875_abnormal_xenobiotic_pharmacok2.10343655
26MP0008872_abnormal_physiological_respon2.05814124
27MP0003787_abnormal_imprinting2.02297223
28MP0000427_abnormal_hair_cycle2.00406201
29MP0002909_abnormal_adrenal_gland1.99184196
30MP0003136_yellow_coat_color1.94578151
31MP0002970_abnormal_white_adipose1.91565939
32MP0000569_abnormal_digit_pigmentation1.86891383
33MP0003959_abnormal_lean_body1.85848196
34MP0005535_abnormal_body_temperature1.82952512
35MP0003705_abnormal_hypodermis_morpholog1.82849731
36MP0004147_increased_porphyrin_level1.81582848
37MP0004885_abnormal_endolymph1.81573647
38MP0002118_abnormal_lipid_homeostasis1.81539236
39MP0009780_abnormal_chondrocyte_physiolo1.81535165
40MP0009046_muscle_twitch1.79589291
41MP0009745_abnormal_behavioral_response1.79225609
42MP0006072_abnormal_retinal_apoptosis1.78219100
43MP0003191_abnormal_cellular_cholesterol1.76068961
44MP0005253_abnormal_eye_physiology1.74645287
45MP0001485_abnormal_pinna_reflex1.72424515
46MP0003011_delayed_dark_adaptation1.71796332
47MP0000383_abnormal_hair_follicle1.68828355
48MP0003880_abnormal_central_pattern1.63305077
49MP0002078_abnormal_glucose_homeostasis1.63240432
50MP0006292_abnormal_olfactory_placode1.61858488
51MP0003283_abnormal_digestive_organ1.59538320
52MP0002938_white_spotting1.58470908
53MP0000372_irregular_coat_pigmentation1.57588280
54MP0004142_abnormal_muscle_tone1.55433394
55MP0004133_heterotaxia1.50546796
56MP0005448_abnormal_energy_balance1.50102977
57MP0002653_abnormal_ependyma_morphology1.47830502
58MP0006276_abnormal_autonomic_nervous1.47336381
59MP0002272_abnormal_nervous_system1.46782258
60MP0002877_abnormal_melanocyte_morpholog1.45990084
61MP0005084_abnormal_gallbladder_morpholo1.44325583
62MP0000631_abnormal_neuroendocrine_gland1.42937272
63MP0002735_abnormal_chemical_nociception1.40160166
64MP0003724_increased_susceptibility_to1.38372796
65MP0003828_pulmonary_edema1.36983281
66MP0001986_abnormal_taste_sensitivity1.34131017
67MP0008775_abnormal_heart_ventricle1.33637048
68MP0006138_congestive_heart_failure1.32774833
69MP0001486_abnormal_startle_reflex1.30795609
70MP0005452_abnormal_adipose_tissue1.26537420
71MP0002572_abnormal_emotion/affect_behav1.26437659
72MP0005174_abnormal_tail_pigmentation1.26164519
73MP0005377_hearing/vestibular/ear_phenot1.25365180
74MP0003878_abnormal_ear_physiology1.25365180
75MP0001984_abnormal_olfaction1.24640283
76MP0005365_abnormal_bile_salt1.23703415
77MP0008961_abnormal_basal_metabolism1.23535702
78MP0003690_abnormal_glial_cell1.23509154
79MP0002277_abnormal_respiratory_mucosa1.22738772
80MP0005379_endocrine/exocrine_gland_phen1.21612424
81MP0001944_abnormal_pancreas_morphology1.20727999
82MP0001881_abnormal_mammary_gland1.20680410
83MP0001879_abnormal_lymphatic_vessel1.19879827
84MP0002928_abnormal_bile_duct1.19843038
85MP0008995_early_reproductive_senescence1.18973642
86MP0001970_abnormal_pain_threshold1.17465595
87MP0005075_abnormal_melanosome_morpholog1.17079342
88MP0010386_abnormal_urinary_bladder1.15933625
89MP0002557_abnormal_social/conspecific_i1.15675329
90MP0002733_abnormal_thermal_nociception1.15513818
91MP0005410_abnormal_fertilization1.13415262
92MP0001756_abnormal_urination1.12837232
93MP0005386_behavior/neurological_phenoty1.12491326
94MP0004924_abnormal_behavior1.12491326
95MP0000609_abnormal_liver_physiology1.12004384
96MP0003045_fibrosis1.11703028
97MP0004742_abnormal_vestibular_system1.11322822
98MP0005389_reproductive_system_phenotype1.09822675
99MP0001529_abnormal_vocalization1.09467516
100MP0002160_abnormal_reproductive_system1.09388797
101MP0001919_abnormal_reproductive_system1.09204387
102MP0002064_seizures1.09168995
103MP0000538_abnormal_urinary_bladder1.07518692
104MP0002067_abnormal_sensory_capabilities1.07376926
105MP0002751_abnormal_autonomic_nervous1.06829062
106MP0005195_abnormal_posterior_eye1.04738954
107MP0002138_abnormal_hepatobiliary_system1.00061341
108MP0003718_maternal_effect0.99192159
109MP0002060_abnormal_skin_morphology0.99165757
110MP0002234_abnormal_pharynx_morphology0.99003676
111MP0003566_abnormal_cell_adhesion0.98888850
112MP0009643_abnormal_urine_homeostasis0.98358655
113MP0003953_abnormal_hormone_level0.96336838
114MP0003137_abnormal_impulse_conducting0.94404958
115MP0005620_abnormal_muscle_contractility0.94184391
116MP0001905_abnormal_dopamine_level0.93830178
117MP0003186_abnormal_redox_activity0.93554760
118MP0004145_abnormal_muscle_electrophysio0.93208107
119MP0002166_altered_tumor_susceptibility0.90840689
120MP0000750_abnormal_muscle_regeneration0.90255982
121MP0000751_myopathy0.90229206
122MP0000647_abnormal_sebaceous_gland0.90210635
123MP0000026_abnormal_inner_ear0.89949714
124MP0002638_abnormal_pupillary_reflex0.89770144
125MP0002163_abnormal_gland_morphology0.89632720
126MP0010678_abnormal_skin_adnexa0.88985302
127MP0002752_abnormal_somatic_nervous0.88729903
128MP0003195_calcinosis0.88672813
129MP0002184_abnormal_innervation0.88357328
130MP0002063_abnormal_learning/memory/cond0.85946411
131MP0002168_other_aberrant_phenotype0.85577774
132MP0003121_genomic_imprinting0.85287636
133MP0003122_maternal_imprinting0.84795337
134MP0001324_abnormal_eye_pigmentation0.84687437
135MP0005385_cardiovascular_system_phenoty0.84667263
136MP0001544_abnormal_cardiovascular_syste0.84667263
137MP0002734_abnormal_mechanical_nocicepti0.84477125
138MP0000230_abnormal_systemic_arterial0.84253040
139MP0002693_abnormal_pancreas_physiology0.84181629
140MP0005164_abnormal_response_to0.83532249
141MP0001502_abnormal_circadian_rhythm0.82357002
142MP0003698_abnormal_male_reproductive0.81680975
143MP0002229_neurodegeneration0.80849270
144MP0003635_abnormal_synaptic_transmissio0.80807209
145MP0004087_abnormal_muscle_fiber0.78882035
146MP0001727_abnormal_embryo_implantation0.75800985
147MP0005332_abnormal_amino_acid0.75502568
148MP0005058_abnormal_lysosome_morphology0.74695510
149MP0002896_abnormal_bone_mineralization0.73907659
150MP0001501_abnormal_sleep_pattern0.73528214
151MP0002972_abnormal_cardiac_muscle0.71134080
152MP0005584_abnormal_enzyme/coenzyme_acti0.70695156
153MP0002295_abnormal_pulmonary_circulatio0.68945345
154MP0002254_reproductive_system_inflammat0.68338416
155MP0004043_abnormal_pH_regulation0.67968609
156MP0002796_impaired_skin_barrier0.67965268
157MP0000759_abnormal_skeletal_muscle0.67485557
158MP0005645_abnormal_hypothalamus_physiol0.67311732
159MP0003948_abnormal_gas_homeostasis0.65840663
160MP0003221_abnormal_cardiomyocyte_apopto0.65230254
161MP0003279_aneurysm0.64763632
162MP0000343_altered_response_to0.62425184
163MP0005595_abnormal_vascular_smooth0.60598560
164MP0002006_tumorigenesis0.60518347
165MP0005319_abnormal_enzyme/_coenzyme0.59772789
166MP0002108_abnormal_muscle_morphology0.59747677
167MP0005076_abnormal_cell_differentiation0.59456819
168MP0002332_abnormal_exercise_endurance0.59317113
169MP0006036_abnormal_mitochondrial_physio0.59111761
170MP0004036_abnormal_muscle_relaxation0.58935808
171MP0004215_abnormal_myocardial_fiber0.58546124
172MP0002009_preneoplasia0.55204869
173MP0003300_gastrointestinal_ulcer0.54775776
174MP0010234_abnormal_vibrissa_follicle0.53850210
175MP0000249_abnormal_blood_vessel0.53684815
176MP0005167_abnormal_blood-brain_barrier0.53463914
177MP0009672_abnormal_birth_weight0.52606226
178MP0004264_abnormal_extraembryonic_tissu0.50612871
179MP0010630_abnormal_cardiac_muscle0.46926826
180MP0001764_abnormal_homeostasis0.45772957
181MP0001958_emphysema0.45308894
182MP0004084_abnormal_cardiac_muscle0.43806490
183MP0002136_abnormal_kidney_physiology0.43135323

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)7.24089516
2Acanthosis nigricans (HP:0000956)5.81395120
3Insulin-resistant diabetes mellitus (HP:0000831)5.66157858
4Hypertriglyceridemia (HP:0002155)4.92150898
5Hypoglycemic coma (HP:0001325)4.89178827
6Hyperglycinuria (HP:0003108)4.87408638
7Pancreatic cysts (HP:0001737)4.62591529
8Molar tooth sign on MRI (HP:0002419)4.22031900
9Abnormality of midbrain morphology (HP:0002418)4.22031900
10Pancreatic fibrosis (HP:0100732)4.14697234
11Ketoacidosis (HP:0001993)4.11051634
12Congenital stationary night blindness (HP:0007642)4.07016925
13True hermaphroditism (HP:0010459)4.04489854
14Follicular hyperkeratosis (HP:0007502)3.93100622
15Insulin resistance (HP:0000855)3.92697359
16Abnormality of serine family amino acid metabolism (HP:0010894)3.82849995
17Abnormality of glycine metabolism (HP:0010895)3.82849995
18Bone cyst (HP:0012062)3.81280284
19Myoglobinuria (HP:0002913)3.78094076
20Complement deficiency (HP:0004431)3.71819174
21Nephronophthisis (HP:0000090)3.70027146
22Difficulty running (HP:0009046)3.63987279
23Growth hormone excess (HP:0000845)3.55648877
24Abnormality of the renal cortex (HP:0011035)3.54893995
25Cerebral aneurysm (HP:0004944)3.40721757
26Type II lissencephaly (HP:0007260)3.35924972
27Ketosis (HP:0001946)3.30265756
28Abnormality of the renal medulla (HP:0100957)3.30044453
29Attenuation of retinal blood vessels (HP:0007843)3.27805082
30Hyperglycemia (HP:0003074)3.27492375
31Hyperventilation (HP:0002883)3.27062743
32Hyperinsulinemic hypoglycemia (HP:0000825)3.13581958
33Cystic liver disease (HP:0006706)3.07806673
34Chronic hepatic failure (HP:0100626)3.07064668
35Ankle contracture (HP:0006466)3.06303536
36Hypoglycemic seizures (HP:0002173)3.04096519
37Abnormality of fatty-acid metabolism (HP:0004359)3.02984865
38Hydroxyprolinuria (HP:0003080)2.98689453
39Abnormality of proline metabolism (HP:0010907)2.98689453
40Tubular atrophy (HP:0000092)2.95916990
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92916721
42Medial flaring of the eyebrow (HP:0010747)2.91572528
43Broad metatarsal (HP:0001783)2.89002356
44Increased variability in muscle fiber diameter (HP:0003557)2.86679931
45Pendular nystagmus (HP:0012043)2.86387875
46Abolished electroretinogram (ERG) (HP:0000550)2.80457559
47Long foot (HP:0001833)2.79368016
48Hypoalphalipoproteinemia (HP:0003233)2.78697996
49Epidermoid cyst (HP:0200040)2.75414385
50Increased connective tissue (HP:0009025)2.74355294
51Polydipsia (HP:0001959)2.73908892
52Abnormal drinking behavior (HP:0030082)2.73908892
53Type 1 muscle fiber predominance (HP:0003803)2.71247203
54Reduced subcutaneous adipose tissue (HP:0003758)2.70403180
55Hyperthyroidism (HP:0000836)2.70101216
56Myocardial infarction (HP:0001658)2.66681341
57Concave nail (HP:0001598)2.64249260
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63043407
59Skin nodule (HP:0200036)2.62535053
60Generalized aminoaciduria (HP:0002909)2.60731094
61Subcapsular cataract (HP:0000523)2.59124213
62Pigmentary retinal degeneration (HP:0001146)2.59066246
63Hemorrhage of the eye (HP:0011885)2.58474914
64Increased muscle lipid content (HP:0009058)2.58224154
65Rhabdomyolysis (HP:0003201)2.58216232
66Inability to walk (HP:0002540)2.56794388
67Buphthalmos (HP:0000557)2.55813219
68Renal cortical cysts (HP:0000803)2.55392579
69Multiple enchondromatosis (HP:0005701)2.53787363
70Congenital, generalized hypertrichosis (HP:0004540)2.50474431
71Sclerocornea (HP:0000647)2.50240751
72Hyperlipoproteinemia (HP:0010980)2.50238340
73Abnormality of complement system (HP:0005339)2.49185357
74Nausea (HP:0002018)2.48133056
75Abnormal rod and cone electroretinograms (HP:0008323)2.47219645
76Large for gestational age (HP:0001520)2.45203637
77Keratoconus (HP:0000563)2.40618415
78Increased corneal curvature (HP:0100692)2.40618415
79Lissencephaly (HP:0001339)2.38808841
80Spinal rigidity (HP:0003306)2.38629581
81Hyperglycinemia (HP:0002154)2.37481406
82Symptomatic seizures (HP:0011145)2.35936194
83Abnormality of alanine metabolism (HP:0010916)2.35846707
84Hyperalaninemia (HP:0003348)2.35846707
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35846707
86Abnormality of skeletal muscle fiber size (HP:0012084)2.35450407
87Large hands (HP:0001176)2.34716475
88Gait imbalance (HP:0002141)2.32162390
89Pancreatitis (HP:0001733)2.30693010
90Cerebellar dysplasia (HP:0007033)2.30091891
91Gaze-evoked nystagmus (HP:0000640)2.29574678
92Tetraparesis (HP:0002273)2.28180054
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27957839
94Furrowed tongue (HP:0000221)2.27813669
95Hypercortisolism (HP:0001578)2.26194693
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.25224092
97Xanthomatosis (HP:0000991)2.25157278
98Progressive cerebellar ataxia (HP:0002073)2.23582790
99Decreased central vision (HP:0007663)2.23455311
100Abnormal biliary tract physiology (HP:0012439)2.23328956
101Bile duct proliferation (HP:0001408)2.23328956
102Decreased circulating renin level (HP:0003351)2.21368834
103Enlarged penis (HP:0000040)2.21099071
104Premature rupture of membranes (HP:0001788)2.20886081
105Dicarboxylic aciduria (HP:0003215)2.20439128
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20439128
107Congenital primary aphakia (HP:0007707)2.20313479
108Polyuria (HP:0000103)2.18756118
109Bony spicule pigmentary retinopathy (HP:0007737)2.17164090
110Aortic aneurysm (HP:0004942)2.16990744
111Progressive inability to walk (HP:0002505)2.15805141
112Soft skin (HP:0000977)2.15004542
113Bladder diverticulum (HP:0000015)2.13789982
114Stomach cancer (HP:0012126)2.12958503
115Hyperpituitarism (HP:0010514)2.12870039
116Broad-based gait (HP:0002136)2.12352642
117Limb hypertonia (HP:0002509)2.12341340
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.12274276
119Absent/shortened dynein arms (HP:0200106)2.12274276
120Mitochondrial inheritance (HP:0001427)2.11544527
121Aortic dissection (HP:0002647)2.11534953
122Congenital hepatic fibrosis (HP:0002612)2.11051600
123Birth length less than 3rd percentile (HP:0003561)2.10218362
124Increased CSF lactate (HP:0002490)2.09697063
125Aneurysm (HP:0002617)2.09201462
126Nephrogenic diabetes insipidus (HP:0009806)2.08960104
127Patellar aplasia (HP:0006443)2.08045528
128Protruding tongue (HP:0010808)2.07524679
129Male pseudohermaphroditism (HP:0000037)2.06672476
130Genetic anticipation (HP:0003743)2.05918657
131Hypothermia (HP:0002045)2.05735004
132Polygenic inheritance (HP:0010982)2.05520055
133Abnormality of the pons (HP:0007361)2.05495683
134Abnormal cartilage morphology (HP:0002763)2.05134350
135Hyperammonemia (HP:0001987)2.05015568
136Decreased subcutaneous fat (HP:0001002)2.04373395
137Hyporeflexia of lower limbs (HP:0002600)2.03822992
138Turricephaly (HP:0000262)2.03386602
139Prenatal maternal abnormality (HP:0002686)2.01874765
140Congenital glaucoma (HP:0001087)2.01438387
141Hypoplasia of the iris (HP:0007676)2.00991402
142Acute necrotizing encephalopathy (HP:0006965)2.00886477
143Severe muscular hypotonia (HP:0006829)2.00804394
144Venous abnormality (HP:0002624)2.00487765
145Accelerated skeletal maturation (HP:0005616)1.99581531
146Aplasia/Hypoplasia of the patella (HP:0006498)1.98999365
147Anencephaly (HP:0002323)1.97186180
148Optic disc pallor (HP:0000543)1.96486494
149Genital tract atresia (HP:0001827)1.96277412
150Chorioretinal atrophy (HP:0000533)1.96150671
151Hemiparesis (HP:0001269)1.95853733
152Hypoplasia of the pons (HP:0012110)1.93731106
153Pancreatic islet-cell hyperplasia (HP:0004510)1.93408865
154Polar cataract (HP:0010696)1.93113580
155Facial diplegia (HP:0001349)1.92121064
156Optic nerve hypoplasia (HP:0000609)1.91773601
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.91685007
1583-Methylglutaconic aciduria (HP:0003535)1.91663907
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89851764
160Macroorchidism (HP:0000053)1.89811675
161Slender build (HP:0001533)1.89388313
162Postaxial foot polydactyly (HP:0001830)1.89285283
163Mildly elevated creatine phosphokinase (HP:0008180)1.89231862
164Vaginal atresia (HP:0000148)1.89144428
165Fair hair (HP:0002286)1.89102238
166Muscle stiffness (HP:0003552)1.88436815
167Pachygyria (HP:0001302)1.86728876
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86613890
169Acute encephalopathy (HP:0006846)1.85777152
170Methylmalonic acidemia (HP:0002912)1.85168882
171Hematochezia (HP:0002573)1.85059803
172Rectal prolapse (HP:0002035)1.84356147
173Prominent supraorbital ridges (HP:0000336)1.84070013
174Abnormal respiratory motile cilium morphology (HP:0005938)1.83988185
175Abnormal respiratory epithelium morphology (HP:0012253)1.83988185
176Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83686410
177Progressive macrocephaly (HP:0004481)1.83204611
178Absent speech (HP:0001344)1.82446983
179Abnormality of purine metabolism (HP:0004352)1.82109610
180Abnormal urine output (HP:0012590)1.81757414
181Mucopolysacchariduria (HP:0008155)1.81732399
182Urinary glycosaminoglycan excretion (HP:0003541)1.81732399
183Clumsiness (HP:0002312)1.81361059
184Exercise-induced myalgia (HP:0003738)1.80460721
185Congenital sensorineural hearing impairment (HP:0008527)1.79952004
186Febrile seizures (HP:0002373)1.79930934
187Protrusio acetabuli (HP:0003179)1.78063486
188Nephritis (HP:0000123)1.76715053
189Abnormality of the labia minora (HP:0012880)1.76367656
190Tachypnea (HP:0002789)1.76052742
191Retinal atrophy (HP:0001105)1.76015882
192Hepatic necrosis (HP:0002605)1.75775765
193Abnormal ciliary motility (HP:0012262)1.74607683
194Retinal dysplasia (HP:0007973)1.73357712
195Hypomagnesemia (HP:0002917)1.72833070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.79325264
2CAMK1G5.21815095
3TRIB34.88158490
4SIK13.90672758
5BMPR1B3.55747256
6BCKDK3.47372651
7ADRBK23.20747556
8INSRR3.00789955
9MAP4K22.82000486
10ERN12.74530312
11GRK12.57547471
12ZAK2.57279130
13ACVR1B2.48509611
14PINK12.28433272
15PDGFRA2.26605602
16PDK32.26400823
17PDK42.26400823
18NUAK12.26209006
19FRK2.24140416
20RIPK12.10689620
21CASK2.05216600
22TLK12.01014965
23OXSR11.91316705
24MST1R1.91031615
25MAPK131.89619153
26STK391.85302502
27LMTK21.75408112
28PRKAA21.73352602
29DAPK21.61034289
30PKN21.55749761
31PRKD31.53245521
32TXK1.40355056
33FGFR31.40270196
34EPHB21.38625929
35TRIM281.38290490
36TNIK1.33665181
37CDK91.32936094
38FGFR21.31692434
39CAMKK21.30002853
40PDK21.28579095
41MAPKAPK31.28085974
42TGFBR11.23993576
43FLT31.20440215
44MYLK1.17358987
45ADRBK11.17337471
46MET1.13403859
47MAP3K41.13188492
48MKNK21.12747260
49MAP2K11.08324944
50HIPK21.08051873
51TIE11.07128544
52LATS11.04661557
53MUSK0.98942972
54TGFBR20.98432951
55PRKAA10.98399088
56MST40.98275516
57DYRK20.94654349
58JAK10.94053854
59PRKCG0.93845854
60PRKCH0.93448921
61PRKCE0.93189143
62MAP2K60.92680488
63IRAK30.92046338
64VRK10.91818618
65NME10.90617159
66NTRK30.88434151
67JAK20.88264867
68MARK10.87966050
69CDK60.87205189
70PTK60.86494878
71WNK40.85809634
72BRSK20.84173096
73TTN0.83020938
74RET0.82811898
75PIK3CA0.81814367
76MAP3K20.81495672
77FGFR40.81283756
78FER0.80659422
79PAK20.79398410
80PDGFRB0.79223862
81DDR20.78566962
82CAMK10.78293639
83STK38L0.77103527
84BCR0.76785041
85MAP2K70.75530451
86TAOK30.74270290
87PHKG20.72873041
88PHKG10.72873041
89PIK3CG0.71881988
90IKBKB0.71044378
91MAP3K10.68794301
92PDPK10.68435813
93PRKD20.67996563
94PAK30.66682685
95PRKCI0.66561004
96VRK20.65098550
97KSR20.64009449
98MARK20.63817533
99CHUK0.63504569
100CSNK1G20.62297833
101WNK30.62161092
102MTOR0.61600285
103PNCK0.61474051
104PLK20.60908583
105PRKD10.59820715
106GSK3A0.59479446
107PRKACG0.58425221
108TNK20.57934241
109SCYL20.57881711
110MAPK150.57801041
111IGF1R0.56332718
112NTRK10.55640777
113PRKCQ0.54750491
114CSNK1G10.54281174
115PDK10.54021420
116EPHA30.52659057
117TEC0.52436043
118WEE10.51714820
119MAPKAPK50.50028819
120CSNK1G30.49792809
121NEK90.49764083
122FGFR10.49166329
123RPS6KA50.48674303
124AKT30.48087481
125SIK20.47915889
126EIF2AK30.47315008
127CAMK2A0.46479087
128EPHB10.45288120
129CSNK1A10.44414341
130NTRK20.44263190
131JAK30.43031246
132PLK30.42700730
133DMPK0.42243525
134CDC42BPA0.41993232
135ERBB30.41937487
136PRKACA0.41380962
137PTK20.40981653
138STK30.40559275
139WNK10.40483063
140INSR0.40236556
141BMX0.39513727
142MKNK10.39297077
143ITK0.39172038
144PASK0.38932115
145ILK0.38340526
146TSSK60.38307220
147PRKCZ0.37809006
148PTK2B0.35896940
149MAPK110.35888881
150PRKG20.34065432
151ABL20.33471009
152CSNK1A1L0.33383605
153PLK40.33241581
154CSNK1D0.33080122
155PKN10.32754048
156PRKCA0.32191738
157IRAK10.30925521
158LATS20.30676752
159IKBKE0.30589477
160ERBB20.30554669
161TRPM70.30361243
162CAMKK10.30110048
163DAPK30.30052650
164LRRK20.29542853
165SRC0.29081865
166TAF10.29022786
167KDR0.28845620
168KIT0.28605935
169STK110.28454275
170RPS6KB10.27739122
171ROCK10.27396604
172IRAK20.24445744
173SGK30.24036634

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.19515426
2Propanoate metabolism_Homo sapiens_hsa006404.07860551
3PPAR signaling pathway_Homo sapiens_hsa033203.79130115
4Fatty acid biosynthesis_Homo sapiens_hsa000613.78561524
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.73828099
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.37184450
7Fatty acid metabolism_Homo sapiens_hsa012123.05052515
8Phototransduction_Homo sapiens_hsa047442.78548118
9Glycerolipid metabolism_Homo sapiens_hsa005612.63008847
10Fatty acid degradation_Homo sapiens_hsa000712.61211692
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55860562
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46259086
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35436648
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22939287
15Oxidative phosphorylation_Homo sapiens_hsa001902.17748987
16Nitrogen metabolism_Homo sapiens_hsa009102.17412487
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14377976
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98621102
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.97138984
20Selenocompound metabolism_Homo sapiens_hsa004501.95951927
21Pyruvate metabolism_Homo sapiens_hsa006201.95715571
22AMPK signaling pathway_Homo sapiens_hsa041521.95622467
23Nicotine addiction_Homo sapiens_hsa050331.94520712
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90617569
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.75994687
26Ether lipid metabolism_Homo sapiens_hsa005651.73387120
27Protein export_Homo sapiens_hsa030601.69859326
28beta-Alanine metabolism_Homo sapiens_hsa004101.65215311
29Fat digestion and absorption_Homo sapiens_hsa049751.60472885
30Homologous recombination_Homo sapiens_hsa034401.59830107
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56585484
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54423552
33Parkinsons disease_Homo sapiens_hsa050121.53672487
34Type II diabetes mellitus_Homo sapiens_hsa049301.53359955
35Insulin resistance_Homo sapiens_hsa049311.50597672
36Fanconi anemia pathway_Homo sapiens_hsa034601.45762282
37Carbon metabolism_Homo sapiens_hsa012001.42506370
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40624076
39Basal transcription factors_Homo sapiens_hsa030221.39867884
40RNA polymerase_Homo sapiens_hsa030201.39160476
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38167630
42Butanoate metabolism_Homo sapiens_hsa006501.36610501
43Taste transduction_Homo sapiens_hsa047421.33613212
44Insulin signaling pathway_Homo sapiens_hsa049101.28460750
45Glucagon signaling pathway_Homo sapiens_hsa049221.26307153
46Protein digestion and absorption_Homo sapiens_hsa049741.24445643
47Chemical carcinogenesis_Homo sapiens_hsa052041.23346084
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.21688399
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20110253
50Olfactory transduction_Homo sapiens_hsa047401.19983866
51Caffeine metabolism_Homo sapiens_hsa002321.15972113
52One carbon pool by folate_Homo sapiens_hsa006701.15131678
53Morphine addiction_Homo sapiens_hsa050321.14407913
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13677925
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.12187530
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10197664
57Huntingtons disease_Homo sapiens_hsa050161.09534118
58Tryptophan metabolism_Homo sapiens_hsa003801.09421749
59Phenylalanine metabolism_Homo sapiens_hsa003601.08583395
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07333327
61Peroxisome_Homo sapiens_hsa041461.06684270
62RNA degradation_Homo sapiens_hsa030181.05758951
63Renin secretion_Homo sapiens_hsa049241.04613992
64Alzheimers disease_Homo sapiens_hsa050101.02943624
65Cardiac muscle contraction_Homo sapiens_hsa042601.02786711
66ECM-receptor interaction_Homo sapiens_hsa045121.00321547
67Retinol metabolism_Homo sapiens_hsa008300.94625229
68Fatty acid elongation_Homo sapiens_hsa000620.93920513
69Arachidonic acid metabolism_Homo sapiens_hsa005900.92338188
70Serotonergic synapse_Homo sapiens_hsa047260.90723093
71Sulfur metabolism_Homo sapiens_hsa009200.89739688
72Regulation of autophagy_Homo sapiens_hsa041400.89689252
73Tyrosine metabolism_Homo sapiens_hsa003500.89609741
74GABAergic synapse_Homo sapiens_hsa047270.89554546
75Circadian entrainment_Homo sapiens_hsa047130.88110336
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84585060
77Glutamatergic synapse_Homo sapiens_hsa047240.83059499
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.80316669
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78070034
80Focal adhesion_Homo sapiens_hsa045100.73797824
81Staphylococcus aureus infection_Homo sapiens_hsa051500.73498479
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.71491143
83Histidine metabolism_Homo sapiens_hsa003400.71222718
84ABC transporters_Homo sapiens_hsa020100.70174481
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69504544
86Steroid biosynthesis_Homo sapiens_hsa001000.69221501
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67203527
88Proteasome_Homo sapiens_hsa030500.66673753
89Calcium signaling pathway_Homo sapiens_hsa040200.65653340
90Lysine degradation_Homo sapiens_hsa003100.65208912
91Collecting duct acid secretion_Homo sapiens_hsa049660.64767038
92Starch and sucrose metabolism_Homo sapiens_hsa005000.64447493
93Metabolic pathways_Homo sapiens_hsa011000.64225125
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.63907200
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63634919
96Sulfur relay system_Homo sapiens_hsa041220.63530044
97Insulin secretion_Homo sapiens_hsa049110.62714232
98mTOR signaling pathway_Homo sapiens_hsa041500.62140642
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61871987
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61718917
101Mineral absorption_Homo sapiens_hsa049780.59837124
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59426256
103Vitamin digestion and absorption_Homo sapiens_hsa049770.58893097
104Purine metabolism_Homo sapiens_hsa002300.58726577
105Thyroid hormone synthesis_Homo sapiens_hsa049180.55933719
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53916030
107Lysosome_Homo sapiens_hsa041420.52167161
108Circadian rhythm_Homo sapiens_hsa047100.51921536
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51468101
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51370903
111Amoebiasis_Homo sapiens_hsa051460.51027156
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50855593
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49555144
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49304901
115Pentose phosphate pathway_Homo sapiens_hsa000300.48406876
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48326162
117Primary immunodeficiency_Homo sapiens_hsa053400.48096326
118Salivary secretion_Homo sapiens_hsa049700.48053054
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.47065743
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46807453
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44455979
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43618976
123Amphetamine addiction_Homo sapiens_hsa050310.42135638
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41768222
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41738361
126Thyroid cancer_Homo sapiens_hsa052160.41650846
127Cocaine addiction_Homo sapiens_hsa050300.41320319
128Dopaminergic synapse_Homo sapiens_hsa047280.41236684
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39211797
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37656158
131* cAMP signaling pathway_Homo sapiens_hsa040240.36997207
132Proteoglycans in cancer_Homo sapiens_hsa052050.36611332
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34646797
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34227035
135Type I diabetes mellitus_Homo sapiens_hsa049400.33156548
136Vitamin B6 metabolism_Homo sapiens_hsa007500.33074588
137Ovarian steroidogenesis_Homo sapiens_hsa049130.32598584
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32130590
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.31326538
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30632211
141Dorso-ventral axis formation_Homo sapiens_hsa043200.29854003
142Acute myeloid leukemia_Homo sapiens_hsa052210.28887098
143Pancreatic secretion_Homo sapiens_hsa049720.28465621
144Asthma_Homo sapiens_hsa053100.28009156
145Non-homologous end-joining_Homo sapiens_hsa034500.27820027
146Estrogen signaling pathway_Homo sapiens_hsa049150.27629064
147Long-term depression_Homo sapiens_hsa047300.27113299
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.26724241
149Adherens junction_Homo sapiens_hsa045200.26386151
150HIF-1 signaling pathway_Homo sapiens_hsa040660.25361620
151Complement and coagulation cascades_Homo sapiens_hsa046100.23695010
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23494487
153Gastric acid secretion_Homo sapiens_hsa049710.23240835
154Melanogenesis_Homo sapiens_hsa049160.23022906
155Small cell lung cancer_Homo sapiens_hsa052220.22922991
156Melanoma_Homo sapiens_hsa052180.22700996
157Renal cell carcinoma_Homo sapiens_hsa052110.21487534
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.21342660
159Bile secretion_Homo sapiens_hsa049760.20242198
160Glioma_Homo sapiens_hsa052140.20075657
161Prion diseases_Homo sapiens_hsa050200.19635166
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18317822
163Biosynthesis of amino acids_Homo sapiens_hsa012300.17759923
164Arginine biosynthesis_Homo sapiens_hsa002200.17756629
165Tight junction_Homo sapiens_hsa045300.17565585
166Linoleic acid metabolism_Homo sapiens_hsa005910.17505664
167Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17130203
168FoxO signaling pathway_Homo sapiens_hsa040680.15430378
169Dilated cardiomyopathy_Homo sapiens_hsa054140.14198533
170Platelet activation_Homo sapiens_hsa046110.13789313

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