HCAR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine biosynthetic process (GO:0045080)6.32873349
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.92221193
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.92221193
4modulation by symbiont of host immune response (GO:0052553)5.92221193
5positive regulation by symbiont of host defense response (GO:0052509)5.92221193
6modulation by symbiont of host defense response (GO:0052031)5.92221193
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.92221193
8response to peptidoglycan (GO:0032494)5.84878709
9positive regulation of heat generation (GO:0031652)5.20516744
10leukocyte aggregation (GO:0070486)5.16051240
11positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.14472543
12regulation of fever generation (GO:0031620)5.08390384
13negative regulation of cell killing (GO:0031342)5.03045844
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03045844
15regulation of chemokine biosynthetic process (GO:0045073)4.89340957
16positive regulation of gamma-delta T cell activation (GO:0046645)4.75214895
17lipopolysaccharide-mediated signaling pathway (GO:0031663)4.67494526
18regulation of vitamin D biosynthetic process (GO:0060556)4.66761802
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65968009
20response to muramyl dipeptide (GO:0032495)4.54842436
21neutrophil activation involved in immune response (GO:0002283)4.31719458
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30038272
23germinal center formation (GO:0002467)4.16607387
24macrophage activation involved in immune response (GO:0002281)4.15532274
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.12839054
26regulation of vitamin metabolic process (GO:0030656)4.11728251
27regulation of heat generation (GO:0031650)4.10142443
28negative regulation of interleukin-12 production (GO:0032695)4.07446724
29antigen processing and presentation of endogenous antigen (GO:0019883)4.04163194
30regulation of heterotypic cell-cell adhesion (GO:0034114)4.03912900
31positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.02877667
32cellular extravasation (GO:0045123)4.02655661
33type I interferon signaling pathway (GO:0060337)3.92852774
34cellular response to type I interferon (GO:0071357)3.92852774
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91386751
36positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.90761617
37response to type I interferon (GO:0034340)3.89088407
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88716521
39response to host immune response (GO:0052572)3.88716521
40regulation of T-helper 2 cell differentiation (GO:0045628)3.87782692
41hydrogen peroxide biosynthetic process (GO:0050665)3.81257848
42activation of MAPKKK activity (GO:0000185)3.79958683
43regulation of interferon-alpha production (GO:0032647)3.78915867
44positive regulation of interferon-alpha production (GO:0032727)3.78491251
45positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.75890103
46low-density lipoprotein particle clearance (GO:0034383)3.75543174
47respiratory burst (GO:0045730)3.68969446
48microglial cell activation (GO:0001774)3.67947742
49positive regulation of NF-kappaB import into nucleus (GO:0042346)3.66485058
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.65487985
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.59211884
52regulation of gamma-delta T cell activation (GO:0046643)3.59107653
53response to host (GO:0075136)3.58935445
54response to host defenses (GO:0052200)3.58935445
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.58935445
56defense response to protozoan (GO:0042832)3.52057675
57regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.52000399
58granulocyte activation (GO:0036230)3.49364635
59T-helper 1 type immune response (GO:0042088)3.48406745
60immunoglobulin mediated immune response (GO:0016064)3.44041936
61neutrophil mediated immunity (GO:0002446)3.42340275
62superoxide anion generation (GO:0042554)3.39597774
63leukocyte migration involved in inflammatory response (GO:0002523)3.37611581
64regulation of mast cell degranulation (GO:0043304)3.36413499
65detection of molecule of bacterial origin (GO:0032490)3.36128643
66positive regulation of chemokine production (GO:0032722)3.35649688
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34855787
68reactive oxygen species biosynthetic process (GO:1903409)3.34191297
69positive regulation of mast cell activation involved in immune response (GO:0033008)3.31957849
70positive regulation of mast cell degranulation (GO:0043306)3.31957849
71regulation of chronic inflammatory response (GO:0002676)3.31611234
72regulation of podosome assembly (GO:0071801)3.31544346
73regulation of B cell receptor signaling pathway (GO:0050855)3.31539802
74positive regulation of cellular amide metabolic process (GO:0034250)3.29584839
75regulation of interferon-beta biosynthetic process (GO:0045357)3.28632708
76regulation of membrane protein ectodomain proteolysis (GO:0051043)3.28038927
77cytokine secretion (GO:0050663)3.27834434
78negative regulation of T cell mediated immunity (GO:0002710)3.26577178
79detection of other organism (GO:0098543)3.25171851
80response to protozoan (GO:0001562)3.24830091
81positive regulation of type 2 immune response (GO:0002830)3.23538713
82macrophage activation (GO:0042116)3.23441304
83negative regulation of leukocyte mediated immunity (GO:0002704)3.23281341
84positive regulation of acute inflammatory response (GO:0002675)3.18072544
85positive regulation of antigen processing and presentation (GO:0002579)3.16720015
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16599061
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15756365
88neutrophil activation (GO:0042119)3.15141761
89negative regulation of T-helper cell differentiation (GO:0045623)3.14695720
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14695720
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14350827
92myeloid leukocyte mediated immunity (GO:0002444)3.12275210
93negative regulation of lipid storage (GO:0010888)3.11339177
94regulation of mast cell activation involved in immune response (GO:0033006)3.10599649
95chronic inflammatory response (GO:0002544)3.09108280
96detection of bacterium (GO:0016045)3.08819867
97negative regulation of interleukin-6 production (GO:0032715)3.08656422
98response to interleukin-15 (GO:0070672)3.08177412
99regulation of NF-kappaB import into nucleus (GO:0042345)3.07720516
100regulation of histone phosphorylation (GO:0033127)3.06604162
101positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05893166
102negative regulation of type 2 immune response (GO:0002829)3.05371541
103regulation of type 2 immune response (GO:0002828)3.04253758
104positive regulation of p38MAPK cascade (GO:1900745)3.03896186
105detection of external biotic stimulus (GO:0098581)3.03562058
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03116827
107positive regulation of interleukin-6 production (GO:0032755)3.02666569
108regulation of interleukin-8 biosynthetic process (GO:0045414)3.00537002
109regulation of tolerance induction (GO:0002643)3.00300656
110positive regulation of mast cell activation (GO:0033005)2.98812982
111positive regulation of cytokine biosynthetic process (GO:0042108)2.98261347
112myeloid cell activation involved in immune response (GO:0002275)2.97973111
113B cell mediated immunity (GO:0019724)2.97812509
114neutrophil chemotaxis (GO:0030593)2.97553261
115regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97039723
116production of molecular mediator involved in inflammatory response (GO:0002532)2.95960976
117detection of biotic stimulus (GO:0009595)2.95269862
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95022460
119regulation of T cell tolerance induction (GO:0002664)2.94465215
120negative regulation of cytokine production involved in immune response (GO:0002719)2.94341277
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.94066790
122positive regulation of transcription factor import into nucleus (GO:0042993)2.93663157
123regulation of mononuclear cell migration (GO:0071675)2.92603429
124neutrophil migration (GO:1990266)2.88902768
125eosinophil migration (GO:0072677)2.88353111
126negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.87670017
127modulation of growth of symbiont involved in interaction with host (GO:0044144)2.87670017
128regulation of growth of symbiont in host (GO:0044126)2.87670017
129negative regulation of growth of symbiont in host (GO:0044130)2.87670017
130leukocyte cell-cell adhesion (GO:0007159)2.86817976
131regulation of T-helper 1 cell differentiation (GO:0045625)2.86329275
132regulation of leukocyte degranulation (GO:0043300)2.85949192
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85832441
134positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.85605400
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85508970
136interferon-gamma-mediated signaling pathway (GO:0060333)2.84130414
137positive regulation of interleukin-10 production (GO:0032733)2.83347091
138myeloid leukocyte activation (GO:0002274)2.81788038
139negative regulation of toll-like receptor signaling pathway (GO:0034122)2.79683999
140regulation of toll-like receptor signaling pathway (GO:0034121)2.79514906
141positive regulation of interferon-beta production (GO:0032728)2.76757557
142regulation of mast cell activation (GO:0033003)2.75472474
143negative regulation of alpha-beta T cell activation (GO:0046636)2.74171562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.70342096
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.58265590
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.48954164
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.94882159
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.84143299
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.65446461
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65010755
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.64822619
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.49139193
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.46021955
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18030681
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.06427032
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97453487
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70472941
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65539596
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63497175
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55998841
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49855641
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35320739
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19473046
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08522417
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04211391
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99383950
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91423969
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83089604
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82914547
27VDR_24763502_ChIP-Seq_THP-1_Human1.71605563
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71567503
29RUNX_20019798_ChIP-Seq_JUKART_Human1.60968969
30SCL_19346495_ChIP-Seq_HPC-7_Human1.60581337
31SPI1_23547873_ChIP-Seq_NB4_Human1.60254092
32VDR_24787735_ChIP-Seq_THP-1_Human1.58240284
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53855746
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52280510
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52210031
36CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48129256
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46814032
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.45557061
39KDM2B_26808549_Chip-Seq_DND41_Human1.44821887
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.43150485
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.39926974
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37373611
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37235313
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36149996
45SPI1_23127762_ChIP-Seq_K562_Human1.36133691
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35714727
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35714727
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35030647
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34735807
50PU_27001747_Chip-Seq_BMDM_Mouse1.34640668
51MYB_26560356_Chip-Seq_TH2_Human1.34456794
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.33802062
53MAF_26560356_Chip-Seq_TH2_Human1.32458301
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.32438136
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32410233
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32176162
57MAF_26560356_Chip-Seq_TH1_Human1.31381255
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31233629
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.30114434
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27191803
61MYC_22102868_ChIP-Seq_BL_Human1.24658820
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24088004
63SOX2_20726797_ChIP-Seq_SW620_Human1.23640690
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21302409
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17321435
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16580134
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.15176475
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13003019
69TCF7_22412390_ChIP-Seq_EML_Mouse1.11282780
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11064012
71LXR_22292898_ChIP-Seq_THP-1_Human1.10500530
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08334862
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.06570874
74EGR1_19032775_ChIP-ChIP_M12_Human1.05326427
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03698209
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02932628
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02846879
78CLOCK_20551151_ChIP-Seq_293T_Human1.02565702
79VDR_21846776_ChIP-Seq_THP-1_Human1.02500032
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02278949
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01496749
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00553799
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00553799
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00407528
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00291918
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00121745
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99440790
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99220268
89RXR_22108803_ChIP-Seq_LS180_Human0.97979715
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97574625
91CJUN_26792858_Chip-Seq_BT549_Human0.97556834
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97332145
93MYB_26560356_Chip-Seq_TH1_Human0.97294291
94GATA2_19941826_ChIP-Seq_K562_Human0.96963923
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96813442
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96014099
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95994653
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95311872
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95250683
100GATA3_27048872_Chip-Seq_THYMUS_Human0.95177299
101GATA1_22025678_ChIP-Seq_K562_Human0.94849497
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.94024646
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.93934027
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93520535
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93225887
106GATA3_26560356_Chip-Seq_TH2_Human0.93142542
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92724508
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92375337
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91403272
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90466760
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89434922
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89434922
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89434922
114UTX_26944678_Chip-Seq_JUKART_Human0.87550991
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87501402
116LXR_22158963_ChIP-Seq_LIVER_Mouse0.87050363
117BCOR_27268052_Chip-Seq_Bcells_Human0.86636488
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86492257
119BCL6_27268052_Chip-Seq_Bcells_Human0.86119046
120GATA1_19941826_ChIP-Seq_K562_Human0.84421597
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.81385208
122RACK7_27058665_Chip-Seq_MCF-7_Human0.81209801
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79804833
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79543349
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79164672
126PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78539922
127KDM2B_26808549_Chip-Seq_K562_Human0.77574222
128NCOR1_26117541_ChIP-Seq_K562_Human0.75404153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.09867397
2MP0003303_peritoneal_inflammation3.96894708
3MP0003436_decreased_susceptibility_to3.88614203
4MP0003724_increased_susceptibility_to3.71929945
5MP0002148_abnormal_hypersensitivity_rea3.11533304
6MP0001835_abnormal_antigen_presentation3.04984891
7MP0002419_abnormal_innate_immunity3.04812478
8MP0004947_skin_inflammation3.00369563
9MP0005000_abnormal_immune_tolerance2.98092164
10MP0005025_abnormal_response_to2.80697922
11MP0004510_myositis2.57628437
12MP0002254_reproductive_system_inflammat2.54876226
13MP0005387_immune_system_phenotype2.41448154
14MP0001790_abnormal_immune_system2.41448154
15MP0001533_abnormal_skeleton_physiology2.28206504
16MP0002452_abnormal_antigen_presenting2.26373343
17MP0009764_decreased_sensitivity_to2.20356128
18MP0002723_abnormal_immune_serum2.19024384
19MP0006082_CNS_inflammation2.18832358
20MP0001800_abnormal_humoral_immune2.11734444
21MP0000343_altered_response_to2.10066844
22MP0009278_abnormal_bone_marrow2.09700302
23MP0003453_abnormal_keratinocyte_physiol2.08611066
24MP0000685_abnormal_immune_system2.06659877
25MP0003075_altered_response_to1.95377133
26MP0003448_altered_tumor_morphology1.94198609
27MP0002405_respiratory_system_inflammati1.87216983
28MP0001819_abnormal_immune_cell1.85106310
29MP0001845_abnormal_inflammatory_respons1.85091738
30MP0005671_abnormal_response_to1.84160325
31MP0002420_abnormal_adaptive_immunity1.84100308
32MP0005464_abnormal_platelet_physiology1.83603154
33MP0003300_gastrointestinal_ulcer1.81977418
34MP0002006_tumorigenesis1.79811164
35MP0005076_abnormal_cell_differentiation1.75877668
36MP0002796_impaired_skin_barrier1.70578279
37MP0001853_heart_inflammation1.69953337
38MP0005167_abnormal_blood-brain_barrier1.69905967
39MP0009840_abnormal_foam_cell1.69009861
40MP0003828_pulmonary_edema1.62788007
41MP0008469_abnormal_protein_level1.62249688
42MP0003191_abnormal_cellular_cholesterol1.59476416
43MP0002132_abnormal_respiratory_system1.57645597
44MP0008260_abnormal_autophagy1.56492051
45MP0010352_gastrointestinal_tract_polyps1.52035604
46MP0010155_abnormal_intestine_physiology1.49145727
47MP0000858_altered_metastatic_potential1.42732073
48MP0005164_abnormal_response_to1.41652722
49MP0001216_abnormal_epidermal_layer1.41334206
50MP0001851_eye_inflammation1.38260784
51MP0005058_abnormal_lysosome_morphology1.37969483
52MP0002998_abnormal_bone_remodeling1.36014891
53MP0009333_abnormal_splenocyte_physiolog1.35624083
54MP0005166_decreased_susceptibility_to1.32354265
55MP0003763_abnormal_thymus_physiology1.29426593
56MP0005451_abnormal_body_composition1.25807767
57MP0000604_amyloidosis1.23411163
58MP0003566_abnormal_cell_adhesion1.21004041
59MP0001545_abnormal_hematopoietic_system1.19778774
60MP0005397_hematopoietic_system_phenotyp1.19778774
61MP0005390_skeleton_phenotype1.19691201
62MP0003172_abnormal_lysosome_physiology1.19637131
63MP0002877_abnormal_melanocyte_morpholog1.18957499
64MP0000716_abnormal_immune_system1.16827576
65MP0002060_abnormal_skin_morphology1.16501446
66MP0002933_joint_inflammation1.10169768
67MP0005023_abnormal_wound_healing1.10066653
68MP0004858_abnormal_nervous_system1.09225149
69MP0002277_abnormal_respiratory_mucosa1.08180549
70MP0003186_abnormal_redox_activity1.08035367
71MP0004381_abnormal_hair_follicle1.06767175
72MP0003705_abnormal_hypodermis_morpholog1.06569957
73MP0003183_abnormal_peptide_metabolism1.05513964
74MP0005275_abnormal_skin_tensile1.02485352
75MP0002398_abnormal_bone_marrow1.02414490
76MP0003866_abnormal_defecation1.01183610
77MP0001501_abnormal_sleep_pattern1.01169870
78MP0010234_abnormal_vibrissa_follicle0.99630467
79MP0004782_abnormal_surfactant_physiolog0.99619851
80MP0003045_fibrosis0.96333152
81MP0003656_abnormal_erythrocyte_physiolo0.96113415
82MP0002098_abnormal_vibrissa_morphology0.95876947
83MP0009765_abnormal_xenobiotic_induced0.94934574
84MP0005310_abnormal_salivary_gland0.92558888
85MP0001191_abnormal_skin_condition0.92201450
86MP0009763_increased_sensitivity_to0.89614635
87MP0001663_abnormal_digestive_system0.89269118
88MP0003806_abnormal_nucleotide_metabolis0.88723340
89MP0003195_calcinosis0.88604754
90MP0000383_abnormal_hair_follicle0.87162326
91MP0002429_abnormal_blood_cell0.86326421
92MP0004883_abnormal_blood_vessel0.84460517
93MP0009931_abnormal_skin_appearance0.84368407
94MP0002722_abnormal_immune_system0.81837072
95MP0000689_abnormal_spleen_morphology0.81441361
96MP0001243_abnormal_dermal_layer0.79676848
97MP0000703_abnormal_thymus_morphology0.79079352
98MP0003690_abnormal_glial_cell0.76715433
99MP0001873_stomach_inflammation0.76349092
100MP0008004_abnormal_stomach_pH0.75026087
101MP0005501_abnormal_skin_physiology0.74795327
102MP0003941_abnormal_skin_development0.73945433
103MP0000249_abnormal_blood_vessel0.72832347
104MP0010678_abnormal_skin_adnexa0.71988215
105MP0000465_gastrointestinal_hemorrhage0.71171389
106MP0003795_abnormal_bone_structure0.70675243
107MP0002332_abnormal_exercise_endurance0.70113685
108MP0002138_abnormal_hepatobiliary_system0.68484143
109MP0010771_integument_phenotype0.68476706
110MP0003221_abnormal_cardiomyocyte_apopto0.67006458
111MP0004808_abnormal_hematopoietic_stem0.66817003
112MP0005666_abnormal_adipose_tissue0.66099435
113MP0008874_decreased_physiological_sensi0.65191313
114MP0002166_altered_tumor_susceptibility0.64159924
115MP0005535_abnormal_body_temperature0.64005123
116MP0000367_abnormal_coat/_hair0.63896519
117MP0005377_hearing/vestibular/ear_phenot0.58405115
118MP0003878_abnormal_ear_physiology0.58405115
119MP0003091_abnormal_cell_migration0.58050025
120MP0006054_spinal_hemorrhage0.53689860
121MP0005319_abnormal_enzyme/_coenzyme0.52515921
122MP0002396_abnormal_hematopoietic_system0.51818371

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.98305909
2Recurrent abscess formation (HP:0002722)6.62413404
3Stomatitis (HP:0010280)6.04060483
4Recurrent bacterial skin infections (HP:0005406)5.86484554
5Recurrent gram-negative bacterial infections (HP:0005420)5.61841532
6Elevated erythrocyte sedimentation rate (HP:0003565)5.36892105
7Mediastinal lymphadenopathy (HP:0100721)5.15128401
8Orchitis (HP:0100796)5.02179409
9Abnormality of macrophages (HP:0004311)4.78038008
10Myositis (HP:0100614)4.68483898
11Optic neuritis (HP:0100653)4.66215070
12Retrobulbar optic neuritis (HP:0100654)4.66215070
13Parakeratosis (HP:0001036)4.40089331
14Interstitial pulmonary disease (HP:0006530)4.24882441
15Systemic lupus erythematosus (HP:0002725)3.86348884
16Gingivitis (HP:0000230)3.81578382
17Autoimmune thrombocytopenia (HP:0001973)3.71064161
18Increased cerebral lipofuscin (HP:0011813)3.61986459
19Chronic obstructive pulmonary disease (HP:0006510)3.56793980
20Obstructive lung disease (HP:0006536)3.56793980
21Thick nail (HP:0001805)3.53147568
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.53138916
23Encephalitis (HP:0002383)3.42879030
24Urticaria (HP:0001025)3.38610323
25Vasculitis (HP:0002633)3.37507457
26Recurrent skin infections (HP:0001581)3.33723456
27Pustule (HP:0200039)3.31486468
28Tetraparesis (HP:0002273)3.19028886
29Amyloidosis (HP:0011034)3.11627685
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.09292957
31Increased IgE level (HP:0003212)3.06860677
32Spontaneous hematomas (HP:0007420)3.04831961
33Pulmonary infiltrates (HP:0002113)3.03808197
34Recurrent fungal infections (HP:0002841)3.03297137
35Vacuolated lymphocytes (HP:0001922)3.01392141
36Palmoplantar hyperkeratosis (HP:0000972)3.01320552
37Plantar hyperkeratosis (HP:0007556)2.98403793
38Periodontitis (HP:0000704)2.98267154
39Increased IgM level (HP:0003496)2.88194673
40Keratoconjunctivitis sicca (HP:0001097)2.86487413
41Myocardial infarction (HP:0001658)2.84679859
42Palmar hyperkeratosis (HP:0010765)2.83292265
43Chest pain (HP:0100749)2.82022172
44Cellulitis (HP:0100658)2.80705424
45Pulmonary embolism (HP:0002204)2.73333679
46Abnormality of the pleura (HP:0002103)2.69151175
47Peritonitis (HP:0002586)2.67825839
48Leukocytosis (HP:0001974)2.60881990
49Keratoconjunctivitis (HP:0001096)2.60326399
50Glomerulonephritis (HP:0000099)2.57699068
51Hypergammaglobulinemia (HP:0010702)2.56496017
52Gangrene (HP:0100758)2.56023355
53Gastrointestinal infarctions (HP:0005244)2.53846445
54T lymphocytopenia (HP:0005403)2.52864897
55Abnormality of the peritoneum (HP:0002585)2.51873306
56Loss of speech (HP:0002371)2.49754279
57Abnormality of T cell number (HP:0011839)2.49403337
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46740714
59Nausea (HP:0002018)2.46206928
60Osteolytic defects of the hand bones (HP:0009699)2.45131480
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.45131480
62Vertebral compression fractures (HP:0002953)2.42244335
63Arterial thrombosis (HP:0004420)2.41757818
64Prolonged bleeding time (HP:0003010)2.41218529
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.36428891
66Segmental peripheral demyelination/remyelination (HP:0003481)2.35662762
67Premature loss of primary teeth (HP:0006323)2.33780561
68Glomerulopathy (HP:0100820)2.32796912
69Keratitis (HP:0000491)2.32036971
70Anhidrosis (HP:0000970)2.31860089
71Inflammation of the large intestine (HP:0002037)2.31244996
72Anorexia (HP:0002039)2.30520204
73Abnormality of the endocardium (HP:0004306)2.30125822
74Vertigo (HP:0002321)2.29770698
75Hypochromic microcytic anemia (HP:0004840)2.28498536
76Dysostosis multiplex (HP:0000943)2.26930921
77Hypochromic anemia (HP:0001931)2.26495790
78Nasal polyposis (HP:0100582)2.25185525
79Chronic otitis media (HP:0000389)2.23537031
80Gingival bleeding (HP:0000225)2.23520395
81Acne (HP:0001061)2.22736690
82Meningitis (HP:0001287)2.21470348
83Hematochezia (HP:0002573)2.18223154
84Polyneuropathy (HP:0001271)2.18132484
85Gastrointestinal inflammation (HP:0004386)2.17825149
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17576599
87Prostate neoplasm (HP:0100787)2.17465656
88Osteomyelitis (HP:0002754)2.16280195
89Skin ulcer (HP:0200042)2.15779963
90Axonal loss (HP:0003447)2.13856550
91Increased serum ferritin (HP:0003281)2.12733409
92Granulocytopenia (HP:0001913)2.12249917
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.11519806
94Abnormality of glycolipid metabolism (HP:0010969)2.11519806
95Abnormality of liposaccharide metabolism (HP:0010968)2.11519806
96Hemoptysis (HP:0002105)2.11422296
97Recurrent viral infections (HP:0004429)2.11327011
98Epistaxis (HP:0000421)2.10793688
99Disinhibition (HP:0000734)2.10448018
100Recurrent pneumonia (HP:0006532)2.09899013
101Esophageal neoplasm (HP:0100751)2.08534600
102Neoplasm of head and neck (HP:0012288)2.08534600
103Abnormality of the nasal mucosa (HP:0000433)2.08451024
104Autoimmune hemolytic anemia (HP:0001890)2.02288976
105Episodic fever (HP:0001954)2.00812680
106Nephritis (HP:0000123)2.00169411
107Basal ganglia calcification (HP:0002135)1.99996489
108Purpura (HP:0000979)1.99741937
109Colitis (HP:0002583)1.98770802
110Bone pain (HP:0002653)1.98543715
111Hydroxyprolinuria (HP:0003080)1.98105174
112Abnormality of proline metabolism (HP:0010907)1.98105174
113Abnormality of T cells (HP:0002843)1.96503304
114Eosinophilia (HP:0001880)1.95094717
115Abnormality of the pericardium (HP:0001697)1.94906651
116Congenital ichthyosiform erythroderma (HP:0007431)1.94905250
117Arthralgia (HP:0002829)1.91975019
118Mucopolysacchariduria (HP:0008155)1.90958693
119Urinary glycosaminoglycan excretion (HP:0003541)1.90958693
120Erythema (HP:0010783)1.90070886
121Malnutrition (HP:0004395)1.89724228
122Chronic mucocutaneous candidiasis (HP:0002728)1.88305736
123Recurrent cutaneous fungal infections (HP:0011370)1.88305736
124Petechiae (HP:0000967)1.87834290
125Abnormality of complement system (HP:0005339)1.87488099
126Abnormality of nail color (HP:0100643)1.86710057
127Abnormality of iron homeostasis (HP:0011031)1.85405247
128Sepsis (HP:0100806)1.84448719
129Recurrent bronchitis (HP:0002837)1.82570149
130Slow saccadic eye movements (HP:0000514)1.80789036
131Joint swelling (HP:0001386)1.80709936
132Joint hemorrhage (HP:0005261)1.80491567
133Cheilitis (HP:0100825)1.80073230
134Hepatosplenomegaly (HP:0001433)1.79043897
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74351764
136Abnormality of polysaccharide metabolism (HP:0011012)1.74351764
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74351764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.38430859
2TBK14.10686018
3IRAK33.91417831
4RIPK43.34537027
5BLK3.27697720
6IRAK42.88609961
7EPHB12.86843887
8IKBKE2.86177650
9ERN12.71409992
10IKBKB2.63533419
11MAP4K12.54095127
12TYK22.46974092
13MST42.40718454
14MST1R2.03485026
15CHUK2.01849752
16MAP3K31.94560903
17PRPF4B1.86330928
18TXK1.85874588
19JAK31.73369089
20FGR1.66566312
21STK101.65668036
22IRAK21.62804412
23TNK21.62061018
24CSK1.58435209
25PBK1.42108844
26PIM21.40845398
27EPHA31.39918824
28ZAP701.39496019
29JAK11.35081384
30KIT1.31738801
31BMX1.28560195
32RIPK11.25315170
33RPS6KA41.09093386
34TAOK31.07801052
35JAK21.07717898
36BMPR21.07193006
37CDC42BPA1.06679019
38EIF2AK21.06030766
39ABL21.05494792
40FGFR31.04761124
41HCK1.03948889
42ERBB41.02307170
43MAP3K111.01739783
44MAP3K10.99954745
45SYK0.98335496
46MARK30.96619772
47TGFBR20.93820846
48PRKG20.93467953
49LRRK20.88306177
50FGFR40.85285108
51MARK20.84265996
52BTK0.82769633
53MAP3K60.81996855
54PIM10.81353582
55FES0.81016793
56SIK30.79407325
57MAP3K50.77320398
58PTK60.76115486
59LYN0.75314995
60MAP2K30.74634936
61CSF1R0.73434392
62LCK0.71156623
63PDK10.70831766
64MAPKAPK20.70275022
65PIK3CG0.69767857
66PDPK10.69426095
67CLK10.69283717
68MATK0.67853250
69PRKD20.64594482
70MAP3K130.63246309
71ALK0.63153110
72IRAK10.63102243
73MAP3K20.62490383
74GRK70.59734239
75ERBB30.59728042
76KSR20.59071721
77EGFR0.57952919
78ABL10.57736530
79MAPK70.57390985
80PRKCD0.56396333
81MAPK40.54938490
82TRPM70.54557980
83MAP2K60.54518444
84TEC0.54363883
85DDR20.53246446
86TESK20.51299667
87HIPK20.50907367
88TTN0.49811727
89MAP3K100.48290249
90RPS6KA10.48015347
91MET0.45625451
92DYRK1B0.44323649
93SIK20.43557862
94GSK3A0.43312489
95TAOK10.43198406
96PTK2B0.41714938
97MOS0.40143524
98NEK90.40031994
99SIK10.38415752
100MAPK120.38379606
101MAP2K40.38074747
102DAPK20.37641881
103MAP3K120.37518865
104TAOK20.37479808
105DYRK30.37282486
106TESK10.36306667
107MAP3K70.35445959
108STK380.35332437
109KSR10.35059653
110RPS6KL10.34775384
111RPS6KC10.34775384
112GRK60.34653987
113SGK30.34423136
114STK240.32414409
115PRKAA20.32389981
116RAF10.32082218
117CDK190.31915197
118PAK40.31832113
119SMG10.31196303
120ITK0.31177590
121STK110.30507541
122RET0.28999763
123FYN0.28270489
124RPS6KA60.24352627
125CDK60.24178085
126MAPK30.24050499
127TRIB30.23519584
128BCR0.22067937
129PDGFRB0.20641947
130YES10.20232850
131PRKCQ0.19361419
132NLK0.17308504
133MAP2K20.17239668

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.99972235
2Graft-versus-host disease_Homo sapiens_hsa053323.58918001
3Staphylococcus aureus infection_Homo sapiens_hsa051503.20277567
4Legionellosis_Homo sapiens_hsa051343.05774958
5NOD-like receptor signaling pathway_Homo sapiens_hsa046213.02709815
6Malaria_Homo sapiens_hsa051442.84513915
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.80137133
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.69036068
9Pertussis_Homo sapiens_hsa051332.55547952
10Osteoclast differentiation_Homo sapiens_hsa043802.51002960
11Type I diabetes mellitus_Homo sapiens_hsa049402.41038445
12Asthma_Homo sapiens_hsa053102.41037287
13African trypanosomiasis_Homo sapiens_hsa051432.34331992
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29656974
15Allograft rejection_Homo sapiens_hsa053302.24518556
16Tuberculosis_Homo sapiens_hsa051522.24189808
17Rheumatoid arthritis_Homo sapiens_hsa053232.19701551
18TNF signaling pathway_Homo sapiens_hsa046682.16511480
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91308894
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83671965
21Salmonella infection_Homo sapiens_hsa051321.83018976
22Toxoplasmosis_Homo sapiens_hsa051451.66538078
23Measles_Homo sapiens_hsa051621.64760763
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64364712
25Hematopoietic cell lineage_Homo sapiens_hsa046401.63968538
26Influenza A_Homo sapiens_hsa051641.57061782
27Phagosome_Homo sapiens_hsa041451.40414461
28B cell receptor signaling pathway_Homo sapiens_hsa046621.35530695
29Herpes simplex infection_Homo sapiens_hsa051681.32268127
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29814385
31Lysosome_Homo sapiens_hsa041421.26040015
32Amoebiasis_Homo sapiens_hsa051461.22671292
33Apoptosis_Homo sapiens_hsa042101.16320650
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.15278219
35Shigellosis_Homo sapiens_hsa051311.12086307
36Chemokine signaling pathway_Homo sapiens_hsa040621.09182472
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.07557157
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06744552
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02010348
40Prion diseases_Homo sapiens_hsa050201.00659533
41Hepatitis C_Homo sapiens_hsa051600.98682740
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94659851
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.92634955
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92194039
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91353558
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.91051604
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89345057
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87610095
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.87422208
50Other glycan degradation_Homo sapiens_hsa005110.87033906
51Hepatitis B_Homo sapiens_hsa051610.86704692
52Acute myeloid leukemia_Homo sapiens_hsa052210.79319590
53T cell receptor signaling pathway_Homo sapiens_hsa046600.78195351
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76020878
55Antigen processing and presentation_Homo sapiens_hsa046120.75322334
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.71090308
57Complement and coagulation cascades_Homo sapiens_hsa046100.68898318
58Non-small cell lung cancer_Homo sapiens_hsa052230.68493780
59Autoimmune thyroid disease_Homo sapiens_hsa053200.66196740
60Mineral absorption_Homo sapiens_hsa049780.65373201
61Notch signaling pathway_Homo sapiens_hsa043300.61758237
62Bladder cancer_Homo sapiens_hsa052190.59382163
63Sphingolipid metabolism_Homo sapiens_hsa006000.57904820
64VEGF signaling pathway_Homo sapiens_hsa043700.56191157
65Viral myocarditis_Homo sapiens_hsa054160.53594597
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.53382616
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50098081
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.49067091
69Dorso-ventral axis formation_Homo sapiens_hsa043200.48718636
70Chronic myeloid leukemia_Homo sapiens_hsa052200.48485599
71Type II diabetes mellitus_Homo sapiens_hsa049300.47772047
72Insulin resistance_Homo sapiens_hsa049310.47022733
73GnRH signaling pathway_Homo sapiens_hsa049120.45393041
74HIF-1 signaling pathway_Homo sapiens_hsa040660.45066818
75Epstein-Barr virus infection_Homo sapiens_hsa051690.44253531
76Prolactin signaling pathway_Homo sapiens_hsa049170.44089316
77Caffeine metabolism_Homo sapiens_hsa002320.44001283
78Pancreatic cancer_Homo sapiens_hsa052120.39804579
79Platelet activation_Homo sapiens_hsa046110.38699652
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37251507
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36697408
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36616367
83MAPK signaling pathway_Homo sapiens_hsa040100.36424577
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35972746
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35578971
86Choline metabolism in cancer_Homo sapiens_hsa052310.34725478
87Proteoglycans in cancer_Homo sapiens_hsa052050.33390183
88Endometrial cancer_Homo sapiens_hsa052130.32370174
89Collecting duct acid secretion_Homo sapiens_hsa049660.32045704
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30971367
91Small cell lung cancer_Homo sapiens_hsa052220.30422959
92Insulin signaling pathway_Homo sapiens_hsa049100.30297676
93Fatty acid biosynthesis_Homo sapiens_hsa000610.29568063
94Rap1 signaling pathway_Homo sapiens_hsa040150.28550087
95ErbB signaling pathway_Homo sapiens_hsa040120.28359170
96Arachidonic acid metabolism_Homo sapiens_hsa005900.28172780
97mTOR signaling pathway_Homo sapiens_hsa041500.28159109
98Prostate cancer_Homo sapiens_hsa052150.24070019
99FoxO signaling pathway_Homo sapiens_hsa040680.23265386
100HTLV-I infection_Homo sapiens_hsa051660.21451771
101Viral carcinogenesis_Homo sapiens_hsa052030.21258973
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20763102
103MicroRNAs in cancer_Homo sapiens_hsa052060.18647521
104Histidine metabolism_Homo sapiens_hsa003400.17529723
105Primary immunodeficiency_Homo sapiens_hsa053400.16385632
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13295266
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13119189
108Endocytosis_Homo sapiens_hsa041440.12627895
109Steroid biosynthesis_Homo sapiens_hsa001000.12372246
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11578045
111Vibrio cholerae infection_Homo sapiens_hsa051100.11037488
112Renal cell carcinoma_Homo sapiens_hsa052110.10904447
113p53 signaling pathway_Homo sapiens_hsa041150.10373026
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10080006

Most similar genes based on co-expression Upload to Enrichr

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