HCCS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.73256878
2central nervous system myelination (GO:0022010)5.73256878
3protein maturation by protein folding (GO:0022417)4.67445022
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64319163
5negative regulation of neurotransmitter secretion (GO:0046929)4.60462606
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.34656099
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26983371
8ATP synthesis coupled proton transport (GO:0015986)4.26983371
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.25024219
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.20838846
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.13600623
12establishment of integrated proviral latency (GO:0075713)4.10214656
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07805999
14negative regulation of ligase activity (GO:0051352)4.07805999
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.03020331
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.01295489
17creatine metabolic process (GO:0006600)3.90259365
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.85503382
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83385754
20nucleobase-containing small molecule interconversion (GO:0015949)3.83136759
21ribosome assembly (GO:0042255)3.76879784
22positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73524326
23regulation of mitochondrial translation (GO:0070129)3.73396005
24regulation of cellular amino acid metabolic process (GO:0006521)3.68527626
25respiratory electron transport chain (GO:0022904)3.65782252
26regulation of acyl-CoA biosynthetic process (GO:0050812)3.61813191
27establishment of viral latency (GO:0019043)3.58822305
28negative regulation of neurotransmitter transport (GO:0051589)3.57873597
29positive regulation of ligase activity (GO:0051351)3.57229318
30regulation of cofactor metabolic process (GO:0051193)3.53511648
31regulation of coenzyme metabolic process (GO:0051196)3.53511648
32electron transport chain (GO:0022900)3.53424302
33COPI coating of Golgi vesicle (GO:0048205)3.51988919
34Golgi transport vesicle coating (GO:0048200)3.51988919
35regulation of ubiquitin-protein transferase activity (GO:0051438)3.50921208
36DNA deamination (GO:0045006)3.49650059
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44211334
38proteasome assembly (GO:0043248)3.42498927
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41756007
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41756007
41oxidative phosphorylation (GO:0006119)3.41396615
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.40989118
43termination of RNA polymerase III transcription (GO:0006386)3.40989118
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39718985
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39718985
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39718985
47regulation of ligase activity (GO:0051340)3.38119057
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.36893239
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36893239
50cholesterol biosynthetic process (GO:0006695)3.29390576
51protein neddylation (GO:0045116)3.28626715
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.28288690
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.26748462
54NADH dehydrogenase complex assembly (GO:0010257)3.26748462
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26748462
56mitotic sister chromatid segregation (GO:0000070)3.20728007
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19983253
58cullin deneddylation (GO:0010388)3.19729598
59transcription from mitochondrial promoter (GO:0006390)3.18657102
60protein localization to kinetochore (GO:0034501)3.16238334
61NADH metabolic process (GO:0006734)3.12827087
62protein localization to mitochondrion (GO:0070585)3.12384628
63protein localization to chromosome, centromeric region (GO:0071459)3.10480145
64signal peptide processing (GO:0006465)3.09664048
65IMP biosynthetic process (GO:0006188)3.08429162
66establishment of chromosome localization (GO:0051303)3.07117466
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06549471
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06333447
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05651259
70protein deneddylation (GO:0000338)3.04860634
71deoxyribonucleotide biosynthetic process (GO:0009263)3.02032989
72axon ensheathment (GO:0008366)3.01035720
73ensheathment of neurons (GO:0007272)3.01035720
74fatty acid elongation (GO:0030497)3.00846831
75cell cycle G1/S phase transition (GO:0044843)2.94234949
76G1/S transition of mitotic cell cycle (GO:0000082)2.94234949
77myelination (GO:0042552)2.93166968
78DNA replication initiation (GO:0006270)2.90815671
79ribosomal large subunit biogenesis (GO:0042273)2.89970995
80mitotic nuclear envelope disassembly (GO:0007077)2.89525570
81negative regulation of protein ubiquitination (GO:0031397)2.89481963
82chaperone-mediated protein transport (GO:0072321)2.88991187
83regulation of translational termination (GO:0006449)2.84943505
84ubiquinone metabolic process (GO:0006743)2.84567234
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84459541
86de novo protein folding (GO:0006458)2.84384358
87nuclear pore complex assembly (GO:0051292)2.82966117
88DNA unwinding involved in DNA replication (GO:0006268)2.82940402
89AMP metabolic process (GO:0046033)2.82444642
90sterol biosynthetic process (GO:0016126)2.80810010
91L-methionine salvage (GO:0071267)2.79841045
92L-methionine biosynthetic process (GO:0071265)2.79841045
93amino acid salvage (GO:0043102)2.79841045
94spliceosomal snRNP assembly (GO:0000387)2.78032310
95negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.77934138
96purine nucleobase biosynthetic process (GO:0009113)2.77838807
97establishment of mitochondrion localization (GO:0051654)2.77175442
98positive regulation of cell cycle arrest (GO:0071158)2.76418808
99sister chromatid segregation (GO:0000819)2.74803637
100regulation of sulfur metabolic process (GO:0042762)2.74586342
101pseudouridine synthesis (GO:0001522)2.74507089
102ventricular cardiac muscle cell development (GO:0055015)2.73539266
103telomere maintenance via recombination (GO:0000722)2.73333570
104quinone biosynthetic process (GO:1901663)2.72404394
105ubiquinone biosynthetic process (GO:0006744)2.72404394
106neutrophil activation involved in immune response (GO:0002283)2.71918156
107maturation of 5.8S rRNA (GO:0000460)2.71691432
108mitotic metaphase plate congression (GO:0007080)2.71634526
109rRNA modification (GO:0000154)2.71544086
110mitotic nuclear envelope reassembly (GO:0007084)2.71137646
111nuclear envelope reassembly (GO:0031468)2.71137646
112nuclear envelope disassembly (GO:0051081)2.69926180
113membrane disassembly (GO:0030397)2.69926180
114DNA strand elongation involved in DNA replication (GO:0006271)2.69606068
115de novo posttranslational protein folding (GO:0051084)2.69158440
116tRNA aminoacylation for protein translation (GO:0006418)2.69011562
117regulation of cellular amine metabolic process (GO:0033238)2.68801409
118isoprenoid biosynthetic process (GO:0008299)2.68615413
119peptidyl-histidine modification (GO:0018202)2.67030282
120sarcomere organization (GO:0045214)2.66249241
121tRNA aminoacylation (GO:0043039)2.65987439
122amino acid activation (GO:0043038)2.65987439
123IMP metabolic process (GO:0046040)2.65705983
124rRNA processing (GO:0006364)2.58461967
125rRNA methylation (GO:0031167)2.53969164
126telomere maintenance via semi-conservative replication (GO:0032201)2.53964680
127N-terminal protein amino acid modification (GO:0031365)2.51899599
128tricarboxylic acid cycle (GO:0006099)2.49445462
129negative regulation of potassium ion transmembrane transport (GO:1901380)2.48942658
130DNA strand elongation (GO:0022616)2.48222094
131metaphase plate congression (GO:0051310)2.46899300
132regulation of relaxation of muscle (GO:1901077)2.46301831
133nucleobase biosynthetic process (GO:0046112)2.45984742
134CENP-A containing nucleosome assembly (GO:0034080)2.45657913
135rRNA metabolic process (GO:0016072)2.45028130
136tissue regeneration (GO:0042246)2.44224569
137protein complex biogenesis (GO:0070271)2.43616306
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43487620
139nucleotide transmembrane transport (GO:1901679)2.43461313
140negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.42861859
141peptidyl-threonine dephosphorylation (GO:0035970)2.42806249
142cellular response to nicotine (GO:0071316)2.42026758
143maturation of SSU-rRNA (GO:0030490)2.41296841
144formation of translation preinitiation complex (GO:0001731)2.40886713
145establishment of protein localization to mitochondrion (GO:0072655)2.40774762
146folic acid-containing compound biosynthetic process (GO:0009396)2.38443747
147mitochondrial respiratory chain complex assembly (GO:0033108)2.38314324
148protein targeting to mitochondrion (GO:0006626)2.38145527
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37076498
150negative regulation of T-helper cell differentiation (GO:0045623)2.37033950
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37033950
152negative regulation of execution phase of apoptosis (GO:1900118)2.36728307
153ribosomal small subunit biogenesis (GO:0042274)2.35621095
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35024734
155pteridine-containing compound biosynthetic process (GO:0042559)2.34599917
156chromatin remodeling at centromere (GO:0031055)2.34092465
157somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.33803036
158isotype switching (GO:0045190)2.33803036
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.33803036
160long-chain fatty acid biosynthetic process (GO:0042759)2.33410800
161negative regulation of protein localization to cell surface (GO:2000009)2.33099894
162regulation of pigment cell differentiation (GO:0050932)2.30651531
163DNA replication checkpoint (GO:0000076)2.30476704
164mitotic recombination (GO:0006312)2.30092421
165myelin maintenance (GO:0043217)2.29756162
166regulation of actin filament-based movement (GO:1903115)2.28630928
167ribosome biogenesis (GO:0042254)2.28101891
168mitotic chromosome condensation (GO:0007076)2.27356386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.31194143
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16526764
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16025534
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.87614973
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.65260030
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.55760204
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.00127053
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.85328998
9VDR_23849224_ChIP-Seq_CD4+_Human2.81933865
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78351246
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75129601
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70753307
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69782795
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64545144
15ELK1_19687146_ChIP-ChIP_HELA_Human2.55213463
16DCP1A_22483619_ChIP-Seq_HELA_Human2.50577653
17* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45101364
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43491145
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33818748
20FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.27868257
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23390698
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20379250
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14372027
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09417602
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09103570
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08869326
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07791885
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07437050
29ZNF263_19887448_ChIP-Seq_K562_Human2.04682938
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99180719
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96874269
32FOXP3_21729870_ChIP-Seq_TREG_Human1.94398834
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89285038
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87711030
35AR_21909140_ChIP-Seq_LNCAP_Human1.77329985
36* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76963708
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76607691
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75857684
39XRN2_22483619_ChIP-Seq_HELA_Human1.75285311
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70540402
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70285928
42TFEB_21752829_ChIP-Seq_HELA_Human1.70016921
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69988025
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.65016135
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64314173
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60931957
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60743532
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58691542
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.55817868
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.55436438
51GABP_19822575_ChIP-Seq_HepG2_Human1.53183613
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51051168
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50635407
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48830423
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48352848
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47149829
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45774032
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44959483
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44067956
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43742393
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42600083
62TTF2_22483619_ChIP-Seq_HELA_Human1.42152563
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38854675
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.37286803
65SPI1_23547873_ChIP-Seq_NB4_Human1.36577451
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34522407
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.33092577
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32832332
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32026671
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30590628
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30052823
72MYB_26560356_Chip-Seq_TH2_Human1.27227144
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27097795
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.24864858
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24821188
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23942158
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.22639853
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22391995
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.22052884
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21612902
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21078515
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20924205
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20684094
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.18698082
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18256741
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18151933
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17778762
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17050133
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16512957
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15060723
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14948341
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14745464
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12387578
94CLOCK_20551151_ChIP-Seq_293T_Human1.11810705
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11478866
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10699020
97* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10210377
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09886701
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.09355632
100TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08657370
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07646647
102MYC_18940864_ChIP-ChIP_HL60_Human1.06881445
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06332357
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.04779321
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03238225
106CIITA_25753668_ChIP-Seq_RAJI_Human1.02782715
107EWS_26573619_Chip-Seq_HEK293_Human1.01095470
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00437143
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00132395
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.98976261
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98112048
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97719150
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97460004
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95743981
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95731759
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95207703
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95199107
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95009004
119MYB_26560356_Chip-Seq_TH1_Human0.94850925
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92398143
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92068113
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90084335
123KDM5A_27292631_Chip-Seq_BREAST_Human0.89675500
124IRF1_19129219_ChIP-ChIP_H3396_Human0.89642692
125* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89546757
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89363971
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89342304
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89299925
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87604546
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87074642
131FUS_26573619_Chip-Seq_HEK293_Human0.85758593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.46049735
2MP0003646_muscle_fatigue2.71969075
3MP0004084_abnormal_cardiac_muscle2.70385085
4MP0002837_dystrophic_cardiac_calcinosis2.64846503
5MP0003221_abnormal_cardiomyocyte_apopto2.57337742
6MP0000920_abnormal_myelination2.57212385
7MP0004233_abnormal_muscle_weight2.38697570
8MP0009697_abnormal_copulation2.38448621
9MP0005451_abnormal_body_composition2.34125765
10MP0010234_abnormal_vibrissa_follicle2.22456449
11MP0003941_abnormal_skin_development2.21040244
12* MP0005330_cardiomyopathy2.18475915
13MP0003136_yellow_coat_color2.13769126
14MP0003786_premature_aging2.13269639
15MP0003806_abnormal_nucleotide_metabolis2.11929966
16MP0004036_abnormal_muscle_relaxation2.11330546
17MP0001529_abnormal_vocalization2.11194277
18* MP0006036_abnormal_mitochondrial_physio2.02264168
19MP0003950_abnormal_plasma_membrane1.99015973
20MP0000749_muscle_degeneration1.93848614
21MP0003724_increased_susceptibility_to1.92067270
22* MP0004215_abnormal_myocardial_fiber1.91357651
23MP0003828_pulmonary_edema1.90644352
24MP0004957_abnormal_blastocyst_morpholog1.89643737
25MP0000747_muscle_weakness1.85835330
26MP0009333_abnormal_splenocyte_physiolog1.80354548
27MP0005671_abnormal_response_to1.77619881
28MP0000465_gastrointestinal_hemorrhage1.75276804
29MP0006035_abnormal_mitochondrial_morpho1.64378663
30MP0010352_gastrointestinal_tract_polyps1.61493743
31MP0005000_abnormal_immune_tolerance1.59179727
32MP0000358_abnormal_cell_content/1.57147765
33MP0003693_abnormal_embryo_hatching1.56494937
34MP0008260_abnormal_autophagy1.54854299
35MP0001835_abnormal_antigen_presentation1.50006739
36MP0001485_abnormal_pinna_reflex1.47118744
37MP0000751_myopathy1.46400150
38MP0010094_abnormal_chromosome_stability1.46314935
39* MP0002106_abnormal_muscle_physiology1.45627186
40MP0003077_abnormal_cell_cycle1.45088051
41MP0002796_impaired_skin_barrier1.44738157
42MP0009379_abnormal_foot_pigmentation1.44526606
43MP0003111_abnormal_nucleus_morphology1.42347281
44MP0004145_abnormal_muscle_electrophysio1.42025853
45MP0003566_abnormal_cell_adhesion1.41986020
46MP0001697_abnormal_embryo_size1.41628055
47MP0000750_abnormal_muscle_regeneration1.38032156
48MP0004087_abnormal_muscle_fiber1.35690273
49MP0001348_abnormal_lacrimal_gland1.35140671
50MP0005501_abnormal_skin_physiology1.34988305
51MP0010030_abnormal_orbit_morphology1.34852598
52MP0006082_CNS_inflammation1.32059923
53* MP0002080_prenatal_lethality1.31258557
54MP0008932_abnormal_embryonic_tissue1.30616868
55MP0004147_increased_porphyrin_level1.30585309
56MP0010307_abnormal_tumor_latency1.30046151
57* MP0001672_abnormal_embryogenesis/_devel1.29857886
58* MP0005380_embryogenesis_phenotype1.29857886
59MP0002163_abnormal_gland_morphology1.29472283
60MP0002972_abnormal_cardiac_muscle1.28087468
61MP0000313_abnormal_cell_death1.27195763
62MP0004510_myositis1.25829576
63MP0009840_abnormal_foam_cell1.25660433
64MP0009785_altered_susceptibility_to1.25142347
65MP0001188_hyperpigmentation1.24001659
66MP0002396_abnormal_hematopoietic_system1.22797070
67MP0004484_altered_response_of1.20454773
68MP0008007_abnormal_cellular_replicative1.19869823
69MP0004043_abnormal_pH_regulation1.19702164
70* MP0003984_embryonic_growth_retardation1.17513302
71MP0008775_abnormal_heart_ventricle1.17224066
72MP0003303_peritoneal_inflammation1.16793302
73MP0002332_abnormal_exercise_endurance1.15296367
74MP0008438_abnormal_cutaneous_collagen1.15086411
75MP0001800_abnormal_humoral_immune1.13391940
76* MP0005369_muscle_phenotype1.13068482
77MP0002723_abnormal_immune_serum1.11542372
78* MP0002088_abnormal_embryonic_growth/wei1.10601735
79MP0004142_abnormal_muscle_tone1.09321005
80MP0004130_abnormal_muscle_cell1.09313582
81MP0003763_abnormal_thymus_physiology1.09283836
82MP0003186_abnormal_redox_activity1.08953920
83MP0005620_abnormal_muscle_contractility1.08054986
84MP0001790_abnormal_immune_system1.07732316
85MP0005387_immune_system_phenotype1.07732316
86MP0003705_abnormal_hypodermis_morpholog1.07182521
87MP0002420_abnormal_adaptive_immunity1.06248291
88MP0002452_abnormal_antigen_presenting1.05399182
89MP0002933_joint_inflammation1.04938162
90MP0009672_abnormal_birth_weight1.04518116
91MP0002148_abnormal_hypersensitivity_rea1.04339443
92MP0002398_abnormal_bone_marrow1.04258224
93MP0001819_abnormal_immune_cell1.03712264
94MP0005408_hypopigmentation1.03088707
95* MP0003137_abnormal_impulse_conducting1.02239571
96MP0004272_abnormal_basement_membrane1.01634084
97MP0000759_abnormal_skeletal_muscle1.00765193
98MP0005058_abnormal_lysosome_morphology1.00594667
99MP0002060_abnormal_skin_morphology1.00327288
100MP0000343_altered_response_to0.99811415
101MP0000490_abnormal_crypts_of0.99429541
102MP0001881_abnormal_mammary_gland0.99066360
103MP0002009_preneoplasia0.98850726
104MP0004185_abnormal_adipocyte_glucose0.97029762
105MP0003690_abnormal_glial_cell0.96892410
106MP0001730_embryonic_growth_arrest0.96700197
107MP0002877_abnormal_melanocyte_morpholog0.96590342
108MP0001727_abnormal_embryo_implantation0.95333121
109* MP0005385_cardiovascular_system_phenoty0.94226364
110* MP0001544_abnormal_cardiovascular_syste0.94226364
111MP0001243_abnormal_dermal_layer0.93976122
112MP0003436_decreased_susceptibility_to0.93432434
113MP0000372_irregular_coat_pigmentation0.93380184
114MP0000716_abnormal_immune_system0.93237182
115MP0002419_abnormal_innate_immunity0.93140408
116MP0001661_extended_life_span0.92884274
117MP0010630_abnormal_cardiac_muscle0.92510759
118MP0005623_abnormal_meninges_morphology0.92395229
119MP0004742_abnormal_vestibular_system0.92221318
120MP0008877_abnormal_DNA_methylation0.91387599
121MP0002086_abnormal_extraembryonic_tissu0.90929651
122MP0003656_abnormal_erythrocyte_physiolo0.90609094
123MP0008058_abnormal_DNA_repair0.90323852
124MP0005384_cellular_phenotype0.89975894
125MP0003123_paternal_imprinting0.89580771
126MP0000350_abnormal_cell_proliferation0.88922678
127MP0000689_abnormal_spleen_morphology0.88482794
128MP0000013_abnormal_adipose_tissue0.86675014
129MP0002405_respiratory_system_inflammati0.86021965
130MP0002269_muscular_atrophy0.84352389
131MP0003718_maternal_effect0.83906414
132MP0003191_abnormal_cellular_cholesterol0.83813117
133MP0002085_abnormal_embryonic_tissue0.83673348
134MP0005165_increased_susceptibility_to0.83637795
135MP0001853_heart_inflammation0.83453347
136MP0005025_abnormal_response_to0.83157268
137MP0001905_abnormal_dopamine_level0.82827186
138MP0005266_abnormal_metabolism0.82450226
139MP0002210_abnormal_sex_determination0.79533720
140MP0005083_abnormal_biliary_tract0.79236974
141MP0005621_abnormal_cell_physiology0.78286792
142MP0002019_abnormal_tumor_incidence0.76770581
143MP0001764_abnormal_homeostasis0.76260920
144MP0000003_abnormal_adipose_tissue0.76206161
145* MP0002084_abnormal_developmental_patter0.73308546
146MP0001216_abnormal_epidermal_layer0.72668310
147MP0003453_abnormal_keratinocyte_physiol0.72620210
148MP0001929_abnormal_gametogenesis0.67417374
149MP0002139_abnormal_hepatobiliary_system0.67301311
150MP0005319_abnormal_enzyme/_coenzyme0.65339615
151MP0000627_abnormal_mammary_gland0.64918633

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.93822372
2Increased serum pyruvate (HP:0003542)4.93822372
3Acute necrotizing encephalopathy (HP:0006965)4.25695411
4Hepatocellular necrosis (HP:0001404)4.25433735
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.21360569
6Abnormality of alanine metabolism (HP:0010916)4.21360569
7Hyperalaninemia (HP:0003348)4.21360569
8Hepatic necrosis (HP:0002605)4.06072469
9Abnormal mitochondria in muscle tissue (HP:0008316)3.83818688
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.75286636
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.75286636
12Mitochondrial inheritance (HP:0001427)3.74550188
13Increased CSF lactate (HP:0002490)3.59169326
14Cerebral hypomyelination (HP:0006808)3.56740370
15Muscle fiber splitting (HP:0003555)3.50619668
16Acute encephalopathy (HP:0006846)3.49070696
17Progressive macrocephaly (HP:0004481)3.22530927
18Ragged-red muscle fibers (HP:0003200)3.22148514
19Increased hepatocellular lipid droplets (HP:0006565)3.15854240
20Exercise-induced muscle cramps (HP:0003710)3.10648503
21Muscle hypertrophy of the lower extremities (HP:0008968)2.96980391
22Lipid accumulation in hepatocytes (HP:0006561)2.94599322
23Peripheral hypomyelination (HP:0007182)2.86079832
24Postnatal microcephaly (HP:0005484)2.79585246
25Rhabdomyolysis (HP:0003201)2.75312178
26Nemaline bodies (HP:0003798)2.74707539
27Leukodystrophy (HP:0002415)2.74205517
28CNS hypomyelination (HP:0003429)2.73599205
29Respiratory failure (HP:0002878)2.72883885
30Increased serum lactate (HP:0002151)2.71497410
31Shoulder girdle muscle weakness (HP:0003547)2.68941773
32Cerebral edema (HP:0002181)2.67386886
33Exertional dyspnea (HP:0002875)2.66026460
34Exercise intolerance (HP:0003546)2.64941566
35Progressive muscle weakness (HP:0003323)2.64713176
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.63404441
37Muscle fiber inclusion bodies (HP:0100299)2.61350281
38Degeneration of anterior horn cells (HP:0002398)2.53610196
39Abnormality of the anterior horn cell (HP:0006802)2.53610196
40Progressive external ophthalmoplegia (HP:0000590)2.49762308
41Lactic acidosis (HP:0003128)2.49081573
42Increased intramyocellular lipid droplets (HP:0012240)2.48491583
43Entropion (HP:0000621)2.46017845
44Distal lower limb muscle weakness (HP:0009053)2.45958744
45Termporal pattern (HP:0011008)2.44681561
46Insidious onset (HP:0003587)2.44681561
47CNS demyelination (HP:0007305)2.43891268
48Rough bone trabeculation (HP:0100670)2.43424448
49Cerebral hemorrhage (HP:0001342)2.42869215
50Abnormalities of placenta or umbilical cord (HP:0001194)2.42408496
51Calf muscle hypertrophy (HP:0008981)2.40751093
52Abnormality of the corticospinal tract (HP:0002492)2.40203884
53Abnormal umbilical cord blood vessels (HP:0011403)2.39980927
54Single umbilical artery (HP:0001195)2.39980927
55Abnormality of the fetal cardiovascular system (HP:0010948)2.39980927
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39405063
57Myopathic facies (HP:0002058)2.38534994
58Respiratory difficulties (HP:0002880)2.38443943
59Trismus (HP:0000211)2.36867278
60Neuroendocrine neoplasm (HP:0100634)2.36391706
61Sparse eyelashes (HP:0000653)2.34287546
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31908305
63Microvesicular hepatic steatosis (HP:0001414)2.30242438
64Parakeratosis (HP:0001036)2.29801031
65Abnormality of placental membranes (HP:0011409)2.29790029
66Amniotic constriction ring (HP:0009775)2.29790029
67Type 1 muscle fiber predominance (HP:0003803)2.27414813
68Pelvic girdle muscle weakness (HP:0003749)2.27189057
69Pheochromocytoma (HP:0002666)2.26178846
70Type I transferrin isoform profile (HP:0003642)2.26112959
71Reduced antithrombin III activity (HP:0001976)2.26109380
72Autoamputation (HP:0001218)2.25015657
73Cholecystitis (HP:0001082)2.24401316
74Abnormal gallbladder physiology (HP:0012438)2.24401316
75Prolonged neonatal jaundice (HP:0006579)2.23305877
76Cutaneous melanoma (HP:0012056)2.22995835
77Increased muscle lipid content (HP:0009058)2.22988979
78Renal Fanconi syndrome (HP:0001994)2.22079956
79Hepatosplenomegaly (HP:0001433)2.20571683
80Poor head control (HP:0002421)2.19861222
81Tetraparesis (HP:0002273)2.17123126
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.16007517
83Palpitations (HP:0001962)2.13299496
843-Methylglutaconic aciduria (HP:0003535)2.13159225
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12080376
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12080376
87Exercise-induced myalgia (HP:0003738)2.11784170
88Abnormality of the musculature of the pelvis (HP:0001469)2.10181743
89Abnormality of the hip-girdle musculature (HP:0001445)2.10181743
90Reduced subcutaneous adipose tissue (HP:0003758)2.09753973
91Abnormality of methionine metabolism (HP:0010901)2.09655561
92Microretrognathia (HP:0000308)2.09027123
93Nausea (HP:0002018)2.08776653
94Premature ovarian failure (HP:0008209)2.08671238
95Abnormality of the umbilical cord (HP:0010881)2.05674755
96Dilated cardiomyopathy (HP:0001644)2.05559616
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05037345
98Increased connective tissue (HP:0009025)2.04710625
99Stomatitis (HP:0010280)2.03153308
100Aplastic anemia (HP:0001915)2.02685009
101Myoglobinuria (HP:0002913)2.00799956
102Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99764042
103Muscle stiffness (HP:0003552)1.98435603
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97073038
105EMG: myopathic abnormalities (HP:0003458)1.96715435
106Abnormal trabecular bone morphology (HP:0100671)1.96119967
107IgM deficiency (HP:0002850)1.95779765
108IgG deficiency (HP:0004315)1.95485634
109Multiple enchondromatosis (HP:0005701)1.95187827
110Lipoatrophy (HP:0100578)1.94592747
111Fasciculations (HP:0002380)1.93624188
112Limb-girdle muscle atrophy (HP:0003797)1.93287121
113Birth length less than 3rd percentile (HP:0003561)1.93038629
114Gout (HP:0001997)1.92822883
115Emotional lability (HP:0000712)1.92231729
116Elevated erythrocyte sedimentation rate (HP:0003565)1.92217696
117Progressive neurologic deterioration (HP:0002344)1.92173959
118Hyperammonemia (HP:0001987)1.89708807
119Microglossia (HP:0000171)1.89194950
120Abnormal number of erythroid precursors (HP:0012131)1.88732081
121Neck muscle weakness (HP:0000467)1.87398964
122Abnormality of serum amino acid levels (HP:0003112)1.86949190
123Lethargy (HP:0001254)1.86251544
124Sudden death (HP:0001699)1.84837590
125Achilles tendon contracture (HP:0001771)1.84471291
126Spastic paraparesis (HP:0002313)1.84091171
127Abnormal protein glycosylation (HP:0012346)1.83347177
128Abnormal glycosylation (HP:0012345)1.83347177
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83347177
130Abnormal protein N-linked glycosylation (HP:0012347)1.83347177
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83208014
132Premature rupture of membranes (HP:0001788)1.83050698
133Split foot (HP:0001839)1.82837056
134Osteolytic defects of the hand bones (HP:0009699)1.82509127
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.82509127
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81572118
137Abnormality of cells of the erythroid lineage (HP:0012130)1.81345811
138Gowers sign (HP:0003391)1.79645984
139T lymphocytopenia (HP:0005403)1.79075432
140Ventricular tachycardia (HP:0004756)1.76816425
141Secondary amenorrhea (HP:0000869)1.73721673
142Abnormality of T cell number (HP:0011839)1.73263649
143Segmental peripheral demyelination/remyelination (HP:0003481)1.73161366
144Pancytopenia (HP:0001876)1.72788113
145Hypoglycemic coma (HP:0001325)1.72567565
146Optic disc pallor (HP:0000543)1.71028593
147Fatigue (HP:0012378)1.70643304
148Rimmed vacuoles (HP:0003805)1.66338283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.41026554
2BUB13.38827888
3NEK13.07416277
4MUSK2.84421996
5ACVR1B2.57487198
6NME22.52430166
7TESK12.43220513
8PBK2.41778066
9EIF2AK12.38718888
10MAP3K122.36375703
11TXK2.28025485
12WEE12.19128529
13VRK22.17139868
14MAPKAPK52.14355108
15EIF2AK31.91251438
16MKNK11.78391128
17OBSCN1.77170571
18LIMK11.71774585
19TEC1.70551205
20MAP4K11.70468169
21MST1R1.70094412
22MKNK21.66980803
23TRIM281.66720097
24EPHB11.66299600
25PAK41.65302257
26TESK21.64350298
27TTN1.61038192
28CLK11.54377141
29SCYL21.51410668
30CDC71.50974956
31DYRK31.45592113
32EPHA21.44008811
33TSSK61.41158463
34PIM21.35651563
35WNK11.34542932
36PKN11.33714807
37ERBB41.32848250
38BCKDK1.31270380
39PLK31.29309330
40SRPK11.25405516
41OXSR11.24926900
42CCNB11.23114492
43MST41.21497659
44JAK31.19692171
45WNK41.16022583
46STK241.15162025
47VRK11.13991274
48MYLK1.07919896
49ADRBK21.07111960
50TRPM71.03334353
51CSNK1G31.01292699
52RPS6KA51.00906247
53RAF11.00894958
54PDK21.00482215
55IRAK10.99689319
56TAOK20.96832581
57MELK0.95518742
58ITK0.93835809
59ARAF0.92894887
60BRSK10.91763667
61BRSK20.91716071
62DYRK20.91587017
63TTK0.90776887
64LATS20.89749179
65PRKCQ0.88973647
66PRKD30.87865899
67IRAK40.87371707
68PDK30.86273826
69PDK40.86273826
70GRK70.85500391
71PLK40.83911306
72MOS0.81652172
73CSNK1A1L0.81392855
74MET0.81388084
75CAMK2D0.81353699
76NLK0.80937853
77RPS6KA40.78855070
78STK100.77732146
79SIK30.76000222
80ALK0.75650547
81BRAF0.75509872
82BCR0.74953300
83PNCK0.74707063
84TNIK0.71472873
85PAK30.71172756
86YES10.71016480
87IRAK30.70273774
88CDK40.69174805
89KDR0.69139873
90STK160.68268353
91ROCK20.67925942
92MAP3K30.67905033
93ILK0.67346601
94CSNK1G10.67311571
95LCK0.67181125
96BMPR1B0.66338660
97BLK0.64615745
98MAP3K50.64150254
99CDK70.62956996
100NME10.62416875
101PHKG20.61581080
102PHKG10.61581080
103KIT0.60735795
104IRAK20.59938169
105CAMK2B0.59338645
106MAP3K80.58955300
107AURKA0.58948702
108LRRK20.58808028
109DAPK10.58749129
110PLK10.58682695
111CHEK10.58581928
112ERBB30.56854907
113ZAK0.55772746
114RPS6KB20.55712272
115CHEK20.55462593
116CSK0.55340587
117AKT20.54606329
118ATR0.54239180
119PIM10.54178523
120UHMK10.53866309
121MAPKAPK30.53777824
122FGR0.53140260
123PAK10.52883180
124ABL20.51601961
125MAP3K90.51173716
126EIF2AK20.50959528
127PTK20.50611404
128PRKD10.49273938
129AURKB0.48797443
130CSNK2A10.46207024
131IKBKB0.45558446
132NEK20.45372519
133CSNK2A20.45276698
134CSNK1G20.44897444
135BTK0.44413734
136DMPK0.43894807
137STK40.43674400
138CAMKK20.43670105
139CAMK2G0.43648591
140STK30.39042465
141TGFBR20.38843757
142PRKCI0.37862390
143BMX0.35346536
144NEK90.34413326
145ATM0.33620523
146STK38L0.25684671
147TAF10.23914755
148CDK80.23477132
149FLT30.21850634
150PRPF4B0.21335219
151CDK180.20896316

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32117694
2RNA polymerase_Homo sapiens_hsa030203.04112514
3Protein export_Homo sapiens_hsa030602.97387590
4Oxidative phosphorylation_Homo sapiens_hsa001902.91606771
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90749329
6Parkinsons disease_Homo sapiens_hsa050122.74658931
7DNA replication_Homo sapiens_hsa030302.60886201
8Fatty acid elongation_Homo sapiens_hsa000622.45120287
9Proteasome_Homo sapiens_hsa030502.43680799
10Vitamin B6 metabolism_Homo sapiens_hsa007502.35389387
11Ribosome_Homo sapiens_hsa030102.19092651
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12122165
13Pyruvate metabolism_Homo sapiens_hsa006202.10032377
14Folate biosynthesis_Homo sapiens_hsa007902.07430111
15Mismatch repair_Homo sapiens_hsa034302.06387475
16Steroid biosynthesis_Homo sapiens_hsa001002.01251582
17Homologous recombination_Homo sapiens_hsa034401.87381303
18Alzheimers disease_Homo sapiens_hsa050101.87142782
19Allograft rejection_Homo sapiens_hsa053301.86374801
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83595329
21Biosynthesis of amino acids_Homo sapiens_hsa012301.79509916
22Nucleotide excision repair_Homo sapiens_hsa034201.72804789
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70167768
24Graft-versus-host disease_Homo sapiens_hsa053321.68202588
25Spliceosome_Homo sapiens_hsa030401.67506872
26Huntingtons disease_Homo sapiens_hsa050161.60753869
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60212745
28Base excision repair_Homo sapiens_hsa034101.60016100
29RNA transport_Homo sapiens_hsa030131.58425180
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54293371
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48790068
32Cell cycle_Homo sapiens_hsa041101.42080529
33Autoimmune thyroid disease_Homo sapiens_hsa053201.41783413
34Ether lipid metabolism_Homo sapiens_hsa005651.40703431
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34884990
36Asthma_Homo sapiens_hsa053101.30591120
37Pyrimidine metabolism_Homo sapiens_hsa002401.30271075
38RNA degradation_Homo sapiens_hsa030181.28992644
39Basal transcription factors_Homo sapiens_hsa030221.25000082
40Cardiac muscle contraction_Homo sapiens_hsa042601.22820289
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19428952
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18235222
43Galactose metabolism_Homo sapiens_hsa000521.15585542
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.11794740
45Non-homologous end-joining_Homo sapiens_hsa034501.11460744
46Primary immunodeficiency_Homo sapiens_hsa053401.09809032
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05505288
48Fructose and mannose metabolism_Homo sapiens_hsa000511.04187120
49Type I diabetes mellitus_Homo sapiens_hsa049401.03597682
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.97766110
51Viral myocarditis_Homo sapiens_hsa054160.94545436
52N-Glycan biosynthesis_Homo sapiens_hsa005100.92045954
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91323484
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88463453
55p53 signaling pathway_Homo sapiens_hsa041150.88452011
56T cell receptor signaling pathway_Homo sapiens_hsa046600.80100921
57Antigen processing and presentation_Homo sapiens_hsa046120.79986017
58Epstein-Barr virus infection_Homo sapiens_hsa051690.78443653
59Renal cell carcinoma_Homo sapiens_hsa052110.77751074
60Fanconi anemia pathway_Homo sapiens_hsa034600.77384900
61Regulation of autophagy_Homo sapiens_hsa041400.75479672
62Purine metabolism_Homo sapiens_hsa002300.73896914
63Vibrio cholerae infection_Homo sapiens_hsa051100.73049598
64Oocyte meiosis_Homo sapiens_hsa041140.72076988
65Phenylalanine metabolism_Homo sapiens_hsa003600.71600299
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70372553
67Propanoate metabolism_Homo sapiens_hsa006400.69136270
68* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68840915
69Rheumatoid arthritis_Homo sapiens_hsa053230.67230894
70Carbon metabolism_Homo sapiens_hsa012000.66645788
71Measles_Homo sapiens_hsa051620.65475157
72Hematopoietic cell lineage_Homo sapiens_hsa046400.65143029
73Sulfur metabolism_Homo sapiens_hsa009200.64703064
74Legionellosis_Homo sapiens_hsa051340.64322945
75Viral carcinogenesis_Homo sapiens_hsa052030.64231713
76Arginine biosynthesis_Homo sapiens_hsa002200.63779864
77Arginine and proline metabolism_Homo sapiens_hsa003300.61672553
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61167905
79Glutathione metabolism_Homo sapiens_hsa004800.58972917
80Pentose phosphate pathway_Homo sapiens_hsa000300.58923816
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58818807
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57654052
83Selenocompound metabolism_Homo sapiens_hsa004500.56169893
84Leishmaniasis_Homo sapiens_hsa051400.56165684
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55918517
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53702365
87B cell receptor signaling pathway_Homo sapiens_hsa046620.53431268
88Sulfur relay system_Homo sapiens_hsa041220.48853421
89Metabolic pathways_Homo sapiens_hsa011000.47009835
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.46255122
91Shigellosis_Homo sapiens_hsa051310.45154961
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43844149
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.43282169
94Malaria_Homo sapiens_hsa051440.42935250
95Salmonella infection_Homo sapiens_hsa051320.42658450
96Fatty acid degradation_Homo sapiens_hsa000710.41166299
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40994667
98Thyroid cancer_Homo sapiens_hsa052160.40895811
99Herpes simplex infection_Homo sapiens_hsa051680.39710947
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38802591
101Phagosome_Homo sapiens_hsa041450.38767770
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38379321
103Linoleic acid metabolism_Homo sapiens_hsa005910.37446064
104mRNA surveillance pathway_Homo sapiens_hsa030150.36915741
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36399187
106Osteoclast differentiation_Homo sapiens_hsa043800.36386437
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36005538
108Systemic lupus erythematosus_Homo sapiens_hsa053220.35877423
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35448324
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.35071348
111Peroxisome_Homo sapiens_hsa041460.35027430
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34943862
113Dilated cardiomyopathy_Homo sapiens_hsa054140.33975508
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33351266
115One carbon pool by folate_Homo sapiens_hsa006700.32912541
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.32181525
117Tyrosine metabolism_Homo sapiens_hsa003500.31539932
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.30001083
119Apoptosis_Homo sapiens_hsa042100.29546959
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28542590
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.28181797
122Sphingolipid metabolism_Homo sapiens_hsa006000.27550376
123beta-Alanine metabolism_Homo sapiens_hsa004100.26633991
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26238510
125Fatty acid metabolism_Homo sapiens_hsa012120.24725623
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23814508
127Bladder cancer_Homo sapiens_hsa052190.23608307
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23038766
129HIF-1 signaling pathway_Homo sapiens_hsa040660.18559654
130Lysosome_Homo sapiens_hsa041420.18472877
131Glucagon signaling pathway_Homo sapiens_hsa049220.17400941
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17386899
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16477730
134Small cell lung cancer_Homo sapiens_hsa052220.14486713
135HTLV-I infection_Homo sapiens_hsa051660.12950544
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12867525

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