HCFC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.49459025
2DNA unwinding involved in DNA replication (GO:0006268)5.33250224
3nuclear pore organization (GO:0006999)5.29870402
4pre-miRNA processing (GO:0031054)5.02357134
5protein localization to kinetochore (GO:0034501)4.75318459
6mitotic sister chromatid cohesion (GO:0007064)4.55942097
7regulation of NFAT protein import into nucleus (GO:0051532)4.48483138
8mitotic nuclear envelope disassembly (GO:0007077)4.25342365
9pore complex assembly (GO:0046931)4.16736811
10sister chromatid segregation (GO:0000819)4.14555893
11negative regulation of histone methylation (GO:0031061)4.13586372
12heterochromatin organization (GO:0070828)4.04737080
13nuclear envelope disassembly (GO:0051081)4.00224968
14membrane disassembly (GO:0030397)4.00224968
15regulation of RNA export from nucleus (GO:0046831)3.98992563
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.95899252
17mitotic chromosome condensation (GO:0007076)3.94815916
18protein localization to chromosome, centromeric region (GO:0071459)3.88708765
19mitotic sister chromatid segregation (GO:0000070)3.88211354
20glucocorticoid receptor signaling pathway (GO:0042921)3.84854400
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.83214008
22DNA duplex unwinding (GO:0032508)3.82467364
23DNA geometric change (GO:0032392)3.79907252
24regulation of translational fidelity (GO:0006450)3.79768558
25regulation of histone H3-K9 methylation (GO:0051570)3.71622387
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65477039
27dosage compensation (GO:0007549)3.63019282
28apoptotic process involved in morphogenesis (GO:0060561)3.62851964
29negative regulation of RNA splicing (GO:0033119)3.58080251
30regulation of histone H3-K27 methylation (GO:0061085)3.50909696
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48477670
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48454927
33folic acid-containing compound biosynthetic process (GO:0009396)3.48091511
34negative regulation of mRNA processing (GO:0050686)3.41285861
35positive regulation of chromosome segregation (GO:0051984)3.39135231
36regulation of sister chromatid cohesion (GO:0007063)3.37975924
37mRNA stabilization (GO:0048255)3.35704093
38RNA stabilization (GO:0043489)3.35704093
39protein-DNA complex disassembly (GO:0032986)3.33072421
40nucleosome disassembly (GO:0006337)3.33072421
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.32327496
42chromatin assembly (GO:0031497)3.31779108
43IMP biosynthetic process (GO:0006188)3.31489395
44negative regulation of erythrocyte differentiation (GO:0045647)3.29949689
45adherens junction assembly (GO:0034333)3.29040974
46alternative mRNA splicing, via spliceosome (GO:0000380)3.28973597
47regulation of spindle organization (GO:0090224)3.28775566
48nuclear envelope organization (GO:0006998)3.24297664
49protein localization to chromosome (GO:0034502)3.24002689
50negative regulation of mRNA metabolic process (GO:1903312)3.23037073
51positive regulation of DNA-dependent DNA replication (GO:2000105)3.22756136
52regulation of chromatin binding (GO:0035561)3.21631388
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.20361923
54regulation of DNA endoreduplication (GO:0032875)3.18675140
55cellular protein complex localization (GO:0034629)3.17388471
56protein complex localization (GO:0031503)3.16673869
57DNA replication-dependent nucleosome organization (GO:0034723)3.14927373
58DNA replication-dependent nucleosome assembly (GO:0006335)3.14927373
59DNA replication initiation (GO:0006270)3.13496818
60regulation of nucleobase-containing compound transport (GO:0032239)3.12252575
61regulation of translational termination (GO:0006449)3.11963368
62translesion synthesis (GO:0019985)3.11700152
63regulation of mitotic spindle organization (GO:0060236)3.10758307
64corticosteroid receptor signaling pathway (GO:0031958)3.08488422
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08456182
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08456182
67positive regulation of mitotic sister chromatid separation (GO:1901970)3.08456182
68V(D)J recombination (GO:0033151)3.07201767
69cell-substrate adherens junction assembly (GO:0007045)3.04689224
70focal adhesion assembly (GO:0048041)3.04689224
71histone H2A monoubiquitination (GO:0035518)3.04510976
72DNA conformation change (GO:0071103)3.03668147
73regulation of gene silencing by RNA (GO:0060966)3.03348478
74regulation of posttranscriptional gene silencing (GO:0060147)3.03348478
75regulation of gene silencing by miRNA (GO:0060964)3.03348478
76NLS-bearing protein import into nucleus (GO:0006607)3.02887427
77peptidyl-lysine dimethylation (GO:0018027)3.02875530
78histone H3-K36 demethylation (GO:0070544)3.02382175
79negative regulation of cell size (GO:0045792)3.00038433
80positive regulation of gene expression, epigenetic (GO:0045815)2.97950432
81peptidyl-arginine omega-N-methylation (GO:0035247)2.97601903
82DNA strand elongation involved in DNA replication (GO:0006271)2.97038119
83positive regulation by host of viral transcription (GO:0043923)2.96016609
84proline biosynthetic process (GO:0006561)2.94510450
85protein export from nucleus (GO:0006611)2.94139869
86cellular response to epidermal growth factor stimulus (GO:0071364)2.92779392
87kinetochore organization (GO:0051383)2.90767094
88positive regulation of RNA splicing (GO:0033120)2.90280984
89activation of Rac GTPase activity (GO:0032863)2.87831507
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87400732
91histone H3-K4 methylation (GO:0051568)2.86301120
92positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.84153010
93gene silencing (GO:0016458)2.83907784
94gene silencing by RNA (GO:0031047)2.83590690
95negative regulation of histone modification (GO:0031057)2.82545055
96regulation of histone methylation (GO:0031060)2.82500277
97cytoplasmic mRNA processing body assembly (GO:0033962)2.81624075
98mRNA transport (GO:0051028)2.81561251
99DNA strand elongation (GO:0022616)2.81426397
100chromatin assembly or disassembly (GO:0006333)2.80923486
101trophectodermal cell differentiation (GO:0001829)2.80761045
102DNA topological change (GO:0006265)2.79658369
103stress granule assembly (GO:0034063)2.78162569
104neural tube development (GO:0021915)2.78017625
105IMP metabolic process (GO:0046040)2.77530249
106regulation of DNA damage checkpoint (GO:2000001)2.77424305
107regulation of chromosome segregation (GO:0051983)2.77177971
108regulation of telomere maintenance via telomerase (GO:0032210)2.77046476
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.76694011
110mitotic metaphase plate congression (GO:0007080)2.76618559
111DNA packaging (GO:0006323)2.76568235
112peptidyl-arginine N-methylation (GO:0035246)2.75821299
113peptidyl-arginine methylation (GO:0018216)2.75821299
114DNA synthesis involved in DNA repair (GO:0000731)2.75767285
115chromatin silencing (GO:0006342)2.75445916
116histone H4-K12 acetylation (GO:0043983)2.75333685
117telomere maintenance via semi-conservative replication (GO:0032201)2.74812776
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.74645202
119regulation of histone H3-K4 methylation (GO:0051569)2.74500770
120intracellular estrogen receptor signaling pathway (GO:0030520)2.72959900
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.71552486
122regulation of mRNA stability (GO:0043488)2.70411782
123chromosome condensation (GO:0030261)2.70361031
124Golgi transport vesicle coating (GO:0048200)2.70223463
125COPI coating of Golgi vesicle (GO:0048205)2.70223463
126convergent extension (GO:0060026)2.68278273
127DNA replication checkpoint (GO:0000076)2.67979030
128ATP-dependent chromatin remodeling (GO:0043044)2.67907403
129negative regulation of chromatin modification (GO:1903309)2.66867849
130mRNA splicing, via spliceosome (GO:0000398)2.66501690
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66501690
132positive regulation of histone H3-K4 methylation (GO:0051571)2.65795626
133negative regulation of gene expression, epigenetic (GO:0045814)2.65772359
134response to epidermal growth factor (GO:0070849)2.64608370
135mitotic G1 DNA damage checkpoint (GO:0031571)2.64408426
136attachment of spindle microtubules to kinetochore (GO:0008608)2.64304954
137RNA splicing, via transesterification reactions (GO:0000375)2.64127908
1383-UTR-mediated mRNA stabilization (GO:0070935)2.63775381
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62808804
140maternal placenta development (GO:0001893)2.61178082
141G1 DNA damage checkpoint (GO:0044783)2.58761390
142formation of translation preinitiation complex (GO:0001731)2.58526494
143embryonic eye morphogenesis (GO:0048048)2.55028275
144embryonic camera-type eye morphogenesis (GO:0048596)2.53840633
145regulation of RNA stability (GO:0043487)2.47751322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.90376111
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.14914908
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72412763
4MYC_22102868_ChIP-Seq_BL_Human3.69069720
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01071015
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79359975
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70920718
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.70569980
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51055732
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30866718
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21234550
12* CIITA_25753668_ChIP-Seq_RAJI_Human2.12662300
13* VDR_21846776_ChIP-Seq_THP-1_Human2.03688993
14LXR_22292898_ChIP-Seq_THP-1_Human2.03599098
15AR_21909140_ChIP-Seq_LNCAP_Human2.03423263
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.00058312
17E2F7_22180533_ChIP-Seq_HELA_Human10.1596949
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82093260
19* TCF7_22412390_ChIP-Seq_EML_Mouse1.81521402
20RACK7_27058665_Chip-Seq_MCF-7_Human1.80516826
21ZNF263_19887448_ChIP-Seq_K562_Human1.79150483
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.78308714
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70397806
24XRN2_22483619_ChIP-Seq_HELA_Human1.65408574
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65258308
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64594718
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64280588
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63723196
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63440227
30* KDM2B_26808549_Chip-Seq_DND41_Human1.62858676
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.62662328
32KDM2B_26808549_Chip-Seq_K562_Human1.59385770
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52184689
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48696226
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48117503
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47299622
37KDM5A_27292631_Chip-Seq_BREAST_Human1.46105818
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45041330
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42173395
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40916888
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39785487
42UTX_26944678_Chip-Seq_JUKART_Human1.38638609
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37365043
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35702938
45* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35357107
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33982046
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32832916
48NANOG_21062744_ChIP-ChIP_HESCs_Human1.28538123
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27817872
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27612511
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.26596356
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26343039
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25876903
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25171644
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25022789
56CREB1_26743006_Chip-Seq_LNCaP_Human1.25018639
57MAF_26560356_Chip-Seq_TH1_Human1.24766414
58* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24675433
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24580683
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24507816
61* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23271254
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22272839
63* P68_20966046_ChIP-Seq_HELA_Human1.21884501
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21623058
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21200027
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20562890
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18837991
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18653027
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.15680732
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15222272
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15168207
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14534144
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14528531
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13498817
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13232165
76* CHD1_26751641_Chip-Seq_LNCaP_Human1.13173250
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13140916
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12738409
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11880499
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10390552
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.10239977
82* MAF_26560356_Chip-Seq_TH2_Human1.09734315
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09608402
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.08775718
85SMC4_20622854_ChIP-Seq_HELA_Human1.08132794
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07986913
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07825164
88NCOR1_26117541_ChIP-Seq_K562_Human1.07587191
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07448894
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07008000
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06952357
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05822683
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05518694
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05335954
95TTF2_22483619_ChIP-Seq_HELA_Human1.05162912
96SCL_19346495_ChIP-Seq_HPC-7_Human1.04907418
97TFEB_21752829_ChIP-Seq_HELA_Human1.04863611
98FOXP3_21729870_ChIP-Seq_TREG_Human1.04555308
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01945298
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01437131
101CLOCK_20551151_ChIP-Seq_293T_Human1.00706848
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.00085380
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99690885
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99338902
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98997201
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98355337
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95324536
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94307576
109RUNX1_27514584_Chip-Seq_MCF-7_Human0.94122512
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93675845
111* MYB_26560356_Chip-Seq_TH1_Human0.93642865
112MYB_26560356_Chip-Seq_TH2_Human0.93112445
113* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92464431
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92449241
115* GABP_19822575_ChIP-Seq_HepG2_Human0.92412920
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91661939
117ATF3_27146783_Chip-Seq_COLON_Human0.90524389
118VDR_24763502_ChIP-Seq_THP-1_Human0.89073321
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87942447
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86679059
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.86506947
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85422498
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85255035
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85188407
125ETS1_20019798_ChIP-Seq_JURKAT_Human0.83922228
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83535328
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83535328
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83535328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.45888601
2MP0003111_abnormal_nucleus_morphology3.42215763
3MP0010352_gastrointestinal_tract_polyps3.35824391
4MP0005076_abnormal_cell_differentiation3.08994870
5MP0008057_abnormal_DNA_replication3.00406218
6MP0003077_abnormal_cell_cycle2.96315691
7MP0003693_abnormal_embryo_hatching2.89713647
8MP0004957_abnormal_blastocyst_morpholog2.80704351
9MP0003705_abnormal_hypodermis_morpholog2.60095939
10MP0002396_abnormal_hematopoietic_system2.43210068
11MP0001730_embryonic_growth_arrest2.42919047
12MP0003123_paternal_imprinting2.40346976
13MP0002249_abnormal_larynx_morphology2.27433620
14MP0005451_abnormal_body_composition2.25859887
15MP0000350_abnormal_cell_proliferation2.25189220
16MP0004185_abnormal_adipocyte_glucose2.23494448
17MP0010307_abnormal_tumor_latency2.20140376
18MP0000537_abnormal_urethra_morphology2.07025086
19MP0003121_genomic_imprinting2.04609129
20MP0004197_abnormal_fetal_growth/weight/2.04292930
21MP0001672_abnormal_embryogenesis/_devel2.03021481
22MP0005380_embryogenesis_phenotype2.03021481
23MP0002084_abnormal_developmental_patter2.00475218
24MP0009278_abnormal_bone_marrow2.00166870
25MP0003984_embryonic_growth_retardation1.96859483
26MP0008007_abnormal_cellular_replicative1.96067266
27MP0004808_abnormal_hematopoietic_stem1.95021290
28MP0002088_abnormal_embryonic_growth/wei1.93756168
29MP0002085_abnormal_embryonic_tissue1.87905182
30MP0001697_abnormal_embryo_size1.87642688
31MP0005409_darkened_coat_color1.86436961
32MP0000566_synostosis1.84532350
33MP0010030_abnormal_orbit_morphology1.82677516
34MP0002086_abnormal_extraembryonic_tissu1.80101627
35MP0004858_abnormal_nervous_system1.79093222
36MP0002009_preneoplasia1.75676072
37MP0008877_abnormal_DNA_methylation1.75059671
38MP0003890_abnormal_embryonic-extraembry1.66558955
39MP0008058_abnormal_DNA_repair1.63833970
40MP0000678_abnormal_parathyroid_gland1.61937167
41MP0002080_prenatal_lethality1.61869101
42MP0009053_abnormal_anal_canal1.58561625
43MP0008932_abnormal_embryonic_tissue1.52007837
44MP0003567_abnormal_fetal_cardiomyocyte1.51955446
45MP0000569_abnormal_digit_pigmentation1.50403222
46MP0000733_abnormal_muscle_development1.48184356
47MP0001849_ear_inflammation1.44496219
48MP0009672_abnormal_birth_weight1.36429882
49MP0000703_abnormal_thymus_morphology1.36232943
50MP0002089_abnormal_postnatal_growth/wei1.36114199
51MP0003566_abnormal_cell_adhesion1.35184271
52MP0000428_abnormal_craniofacial_morphol1.33458218
53MP0009703_decreased_birth_body1.32938806
54MP0001348_abnormal_lacrimal_gland1.31762204
55MP0003300_gastrointestinal_ulcer1.31571365
56MP0001293_anophthalmia1.29956627
57MP0003119_abnormal_digestive_system1.27049200
58MP0001915_intracranial_hemorrhage1.26034430
59MP0005666_abnormal_adipose_tissue1.24992019
60MP0001545_abnormal_hematopoietic_system1.24799884
61MP0005397_hematopoietic_system_phenotyp1.24799884
62MP0001346_abnormal_lacrimal_gland1.23676016
63MP0005257_abnormal_intraocular_pressure1.22015536
64MP0002925_abnormal_cardiovascular_devel1.20486895
65MP0000490_abnormal_crypts_of1.20485585
66MP0003115_abnormal_respiratory_system1.20321709
67MP0002796_impaired_skin_barrier1.18685765
68MP0003935_abnormal_craniofacial_develop1.18147499
69MP0002877_abnormal_melanocyte_morpholog1.16390554
70MP0000313_abnormal_cell_death1.15620491
71MP0003122_maternal_imprinting1.14492642
72MP0004233_abnormal_muscle_weight1.13491722
73MP0008961_abnormal_basal_metabolism1.13154519
74MP0003453_abnormal_keratinocyte_physiol1.12919046
75MP0005501_abnormal_skin_physiology1.12328966
76MP0002019_abnormal_tumor_incidence1.11299812
77MP0006054_spinal_hemorrhage1.06943267
78MP0002092_abnormal_eye_morphology1.02983530
79MP0003787_abnormal_imprinting1.00738904
80MP0002398_abnormal_bone_marrow1.00653385
81MP0002653_abnormal_ependyma_morphology1.00223909
82MP0003861_abnormal_nervous_system0.99681877
83MP0002697_abnormal_eye_size0.99592731
84MP0000003_abnormal_adipose_tissue0.99585732
85MP0005023_abnormal_wound_healing0.98350995
86MP0005375_adipose_tissue_phenotype0.97772774
87MP0003937_abnormal_limbs/digits/tail_de0.96914477
88MP0008260_abnormal_autophagy0.95169894
89MP0000432_abnormal_head_morphology0.94166361
90MP0008770_decreased_survivor_rate0.93910166
91MP0000266_abnormal_heart_morphology0.92709115
92MP0002111_abnormal_tail_morphology0.91542963
93MP0003763_abnormal_thymus_physiology0.89318676
94MP0004264_abnormal_extraembryonic_tissu0.88535823
95MP0002722_abnormal_immune_system0.86998561
96MP0005621_abnormal_cell_physiology0.86107950
97MP0002098_abnormal_vibrissa_morphology0.85306455
98MP0005623_abnormal_meninges_morphology0.85018897
99MP0000534_abnormal_ureter_morphology0.84947349
100MP0010630_abnormal_cardiac_muscle0.84527096
101MP0003385_abnormal_body_wall0.84393421
102MP0003303_peritoneal_inflammation0.84154694
103MP0001661_extended_life_span0.83644828
104MP0003315_abnormal_perineum_morphology0.82495391
105MP0002166_altered_tumor_susceptibility0.80027511
106MP0003091_abnormal_cell_migration0.79642089
107MP0008789_abnormal_olfactory_epithelium0.78590931
108MP0003943_abnormal_hepatobiliary_system0.78017961
109MP0003786_premature_aging0.77960252
110MP0002932_abnormal_joint_morphology0.77945888
111MP0005384_cellular_phenotype0.77619188
112MP0001784_abnormal_fluid_regulation0.77319170
113MP0009931_abnormal_skin_appearance0.75955539
114MP0010234_abnormal_vibrissa_follicle0.75728979
115MP0004381_abnormal_hair_follicle0.75430466
116MP0001873_stomach_inflammation0.75178991
117MP0003755_abnormal_palate_morphology0.75163249
118MP0005187_abnormal_penis_morphology0.75080988
119MP0002970_abnormal_white_adipose0.74772421
120MP0002116_abnormal_craniofacial_bone0.74326002
121MP0005670_abnormal_white_adipose0.74100004
122MP0000759_abnormal_skeletal_muscle0.74097062
123MP0001286_abnormal_eye_development0.73622359
124MP0004087_abnormal_muscle_fiber0.73569303
125MP0005394_taste/olfaction_phenotype0.72194259
126MP0005499_abnormal_olfactory_system0.72194259
127MP0000689_abnormal_spleen_morphology0.71902336
128MP0003942_abnormal_urinary_system0.68648002
129MP0003283_abnormal_digestive_organ0.67886085
130MP0000477_abnormal_intestine_morphology0.67722105
131MP0002114_abnormal_axial_skeleton0.66402380
132MP0002081_perinatal_lethality0.65090090

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.99091254
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.99091254
3Ependymoma (HP:0002888)3.31188129
4Broad face (HP:0000283)3.29975461
5Volvulus (HP:0002580)3.27249956
6Abnormality of the fingertips (HP:0001211)3.16776503
7Increased nuchal translucency (HP:0010880)3.13610056
8Hyperacusis (HP:0010780)2.97746120
9Obstructive sleep apnea (HP:0002870)2.96973887
10Long eyelashes (HP:0000527)2.95714726
11Abnormality of the 4th metacarpal (HP:0010012)2.94405084
12Abnormality of the astrocytes (HP:0100707)2.86106609
13Astrocytoma (HP:0009592)2.86106609
14Proximal placement of thumb (HP:0009623)2.76681107
15Deviation of the thumb (HP:0009603)2.74420941
16Trigonocephaly (HP:0000243)2.68160414
17Medulloblastoma (HP:0002885)2.65968675
18Disproportionate tall stature (HP:0001519)2.62626726
19Selective tooth agenesis (HP:0001592)2.61615382
20Macroorchidism (HP:0000053)2.54784245
21Renal duplication (HP:0000075)2.52560218
22Increased density of long bones (HP:0006392)2.52055432
23Long palpebral fissure (HP:0000637)2.51737681
24Abnormal number of incisors (HP:0011064)2.50411182
25Abnormality of the labia minora (HP:0012880)2.48842329
26Dysmetric saccades (HP:0000641)2.46350601
27Shallow orbits (HP:0000586)2.45937222
28Facial hemangioma (HP:0000329)2.41889965
29High anterior hairline (HP:0009890)2.37509165
30Abnormality of the columella (HP:0009929)2.34489402
31Abnormality of the phalanges of the hallux (HP:0010057)2.32437763
32Septate vagina (HP:0001153)2.29497876
33Ectopic kidney (HP:0000086)2.28829788
34Broad thumb (HP:0011304)2.28500641
35Glioma (HP:0009733)2.27453294
36Prominent nose (HP:0000448)2.27240643
37Heterotopia (HP:0002282)2.27191532
38Neoplasm of the oral cavity (HP:0100649)2.26809381
39Colon cancer (HP:0003003)2.20057165
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19856996
41Patellar dislocation (HP:0002999)2.19043195
42Abnormality of the aortic arch (HP:0012303)2.17628393
43Cutis marmorata (HP:0000965)2.17102994
44Broad palm (HP:0001169)2.16367157
45High pitched voice (HP:0001620)2.16010359
46Deep palmar crease (HP:0006191)2.15387063
47Broad distal phalanx of finger (HP:0009836)2.14107933
48Distal lower limb amyotrophy (HP:0008944)2.13678055
49Renovascular hypertension (HP:0100817)2.10500788
50Skin tags (HP:0010609)2.08924418
51Neoplasm of striated muscle (HP:0009728)2.07035639
52Supernumerary ribs (HP:0005815)2.05881718
53Basal cell carcinoma (HP:0002671)2.04203247
54Flat acetabular roof (HP:0003180)2.04135106
55Obsessive-compulsive behavior (HP:0000722)2.02782554
56Gastrointestinal carcinoma (HP:0002672)2.02475740
57Malignant gastrointestinal tract tumors (HP:0006749)2.02475740
58Cerebral aneurysm (HP:0004944)2.01859369
59Abnormality of the radial head (HP:0003995)2.01815042
60Elfin facies (HP:0004428)2.01716896
61Skull defect (HP:0001362)2.01515670
62Self-mutilation (HP:0000742)2.00479633
63Urethral obstruction (HP:0000796)2.00327529
64Pointed chin (HP:0000307)1.95794215
65Patellar aplasia (HP:0006443)1.94364777
66Asymmetry of the thorax (HP:0001555)1.94214736
67Sparse lateral eyebrow (HP:0005338)1.93794503
68Pseudobulbar signs (HP:0002200)1.93322310
69Bowel incontinence (HP:0002607)1.93107188
70Rhabdomyosarcoma (HP:0002859)1.92689156
71Truncus arteriosus (HP:0001660)1.92222203
72Bowel diverticulosis (HP:0005222)1.91362241
73Broad phalanges of the hand (HP:0009768)1.89905248
74Truncal obesity (HP:0001956)1.89700256
75Thin ribs (HP:0000883)1.89004198
76Advanced eruption of teeth (HP:0006288)1.88527149
77Premature skin wrinkling (HP:0100678)1.88445477
78Atresia of the external auditory canal (HP:0000413)1.88365618
79Deep philtrum (HP:0002002)1.87816684
80Cafe-au-lait spot (HP:0000957)1.87534250
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.86761469
82Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86428936
83Short 1st metacarpal (HP:0010034)1.86428936
84Narrow palate (HP:0000189)1.85911113
85Short phalanx of the thumb (HP:0009660)1.84856854
86Abnormality of the calcaneus (HP:0008364)1.83274147
87Precocious puberty (HP:0000826)1.81992733
88Abnormality of the thoracic spine (HP:0100711)1.81307231
89Supernumerary bones of the axial skeleton (HP:0009144)1.80771948
90Overriding aorta (HP:0002623)1.80434877
91Abnormal large intestine physiology (HP:0012700)1.80415308
92Rib fusion (HP:0000902)1.79815868
93Achilles tendon contracture (HP:0001771)1.79675522
94Preauricular skin tag (HP:0000384)1.79476315
95Low anterior hairline (HP:0000294)1.79337717
96Reticulocytosis (HP:0001923)1.79205092
97Persistence of primary teeth (HP:0006335)1.79033537
98Sandal gap (HP:0001852)1.78924877
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.78709575
100Aplasia/Hypoplasia of the patella (HP:0006498)1.78483879
101Vertebral arch anomaly (HP:0008438)1.78269657
102Insomnia (HP:0100785)1.78062783
103Abnormality of oral frenula (HP:0000190)1.77860794
104Progressive muscle weakness (HP:0003323)1.77751655
105Intestinal fistula (HP:0100819)1.77322538
106Chromsome breakage (HP:0040012)1.77179572
107Overlapping toe (HP:0001845)1.75818500
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75604901
109Sacral dimple (HP:0000960)1.74831960
110Trismus (HP:0000211)1.74614506
111Ankle contracture (HP:0006466)1.74112384
112Turricephaly (HP:0000262)1.72923191
113Arnold-Chiari malformation (HP:0002308)1.72707406
114Broad finger (HP:0001500)1.71815966
115Lower limb amyotrophy (HP:0007210)1.71538608
116Abnormality of chromosome segregation (HP:0002916)1.69866416
117Abnormality of the diencephalon (HP:0010662)1.69679603
118Limited elbow extension (HP:0001377)1.69277994
119Anal stenosis (HP:0002025)1.68917748
120Increased connective tissue (HP:0009025)1.68141826
121Ulnar bowing (HP:0003031)1.66986388
122Bronchomalacia (HP:0002780)1.66293150
123Fibrous tissue neoplasm (HP:0012316)1.64039583
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.63979831
125Germ cell neoplasia (HP:0100728)1.63894021
126Subacute progressive viral hepatitis (HP:0006572)1.63732474
127Smooth philtrum (HP:0000319)1.63383226
128Dislocated radial head (HP:0003083)1.62882002
129Metaphyseal cupping (HP:0003021)1.62429332
130Ankyloglossia (HP:0010296)1.61972195
131Acute lymphatic leukemia (HP:0006721)1.61910123
132Fibroma (HP:0010614)1.61803917
133Spina bifida occulta (HP:0003298)1.61628567
134Degeneration of anterior horn cells (HP:0002398)1.60316673
135Abnormality of the anterior horn cell (HP:0006802)1.60316673
136Genu recurvatum (HP:0002816)1.60284734
137Abnormality of chromosome stability (HP:0003220)1.59967478
138Uterine leiomyosarcoma (HP:0002891)1.59262017
139Leiomyosarcoma (HP:0100243)1.59262017
140Cholecystitis (HP:0001082)1.58958132
141Abnormal gallbladder physiology (HP:0012438)1.58958132
14211 pairs of ribs (HP:0000878)1.57725336
143Attention deficit hyperactivity disorder (HP:0007018)1.57395561
144Midface retrusion (HP:0011800)1.57121499
145Broad phalanx (HP:0006009)1.57022823
146Bicuspid aortic valve (HP:0001647)1.56563120
147Pelvic girdle muscle weakness (HP:0003749)1.56437461
148Megalocornea (HP:0000485)1.56278638
149Abnormality of the salivary glands (HP:0010286)1.56127060
150Abnormality of the humeroradial joint (HP:0100744)1.55596010
151Generalized hypotonia (HP:0001290)1.54445092
152Duplication of thumb phalanx (HP:0009942)1.54015289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.44680364
2SMG14.39622548
3EEF2K3.93776584
4CDC73.87692221
5MAP3K103.52689567
6PRPF4B2.99818663
7BRD42.62458157
8PKN22.59754335
9NEK22.57521485
10TRIB32.46956392
11IRAK32.10554404
12TSSK61.75191012
13CDK41.67261088
14STK101.66386235
15WEE11.63585917
16TTK1.62275192
17ICK1.61499247
18ALK1.56708790
19MTOR1.56441931
20FGFR41.53781367
21RPS6KB21.51714366
22PASK1.49898635
23CAMK1D1.49795606
24LATS11.45899476
25ATR1.45258614
26NEK11.41915676
27TTN1.41072776
28STK31.39206054
29RIPK11.38016509
30CHEK11.36941550
31CDK61.36357756
32SCYL21.35853238
33CDK71.35628426
34CAMK1G1.34579895
35PTK61.26767748
36SIK21.22984236
37MAP3K81.22239955
38MAP4K11.22020906
39BUB11.11929311
40PDGFRA1.10085636
41MKNK11.09136117
42PLK11.08691664
43PRKD31.06275494
44MARK21.02828622
45STK41.01910184
46PAK41.01781482
47CDK21.01077290
48AURKB1.00602060
49PLK30.99375519
50ATM0.99060540
51CHEK20.93180572
52FGFR10.90849785
53TGFBR10.90211145
54LRRK20.90098015
55SIK10.89344736
56DMPK0.89224965
57MAPK110.86765840
58NME20.84106327
59BMX0.82094088
60VRK20.79630508
61LATS20.79606726
62CDK90.79253488
63IRAK20.78157974
64PAK20.77826189
65TAF10.76939598
66GRK60.76893808
67MELK0.76457395
68TAOK20.75926692
69CDK10.75487183
70KSR20.74930077
71MKNK20.70600345
72PNCK0.70366201
73SRPK10.69433765
74CDK80.69364050
75BRSK20.68134720
76RPS6KA40.67675289
77PIM10.65133706
78PRKD20.64033632
79TYRO30.63840914
80TESK20.63005942
81ERN10.62381875
82CSNK1D0.62123324
83RPS6KL10.59919169
84RPS6KC10.59919169
85BRSK10.58816127
86FGFR30.57908842
87PDGFRB0.57641366
88MAPK140.57463448
89PTK20.56986771
90FLT30.56491301
91MAP3K70.54334471
92CLK10.53657502
93CSNK1E0.53156146
94MST1R0.53014691
95TAOK10.52908310
96MAP2K20.52513225
97PRKDC0.52367808
98AKT20.49484706
99MAP3K130.48536416
100CHUK0.46628230
101GSK3B0.45993316
102MAPK10.45514314
103BRAF0.45179921
104MAP3K90.44630666
105KSR10.44497787
106CSF1R0.42994047
107RPS6KA20.42370570
108DYRK30.42102026
109ACVR1B0.41577414
110EPHA20.41567928
111MAPK100.40293762
112RPS6KA60.39950399
113LMTK20.39613835
114CDC42BPA0.39317146
115AKT10.38912078
116RPS6KA10.38670765
117RPS6KB10.38291677
118EIF2AK10.37774278
119AURKA0.37305218
120MAPK80.35645132
121WNK10.35374401
122BTK0.33726608
123FGFR20.33409919
124SGK30.33228029
125PRKAA10.33088398
126HIPK20.33039010
127JAK30.33035238
128NTRK10.32956929
129MAP3K10.32188607
130CAMK40.32122171
131MAPK90.31877883
132MAP2K30.31851584
133SIK30.30331429

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.15096444
2Cell cycle_Homo sapiens_hsa041102.71853954
3RNA transport_Homo sapiens_hsa030132.63104640
4Mismatch repair_Homo sapiens_hsa034302.56182795
5Spliceosome_Homo sapiens_hsa030402.55468077
6mRNA surveillance pathway_Homo sapiens_hsa030152.30904186
7One carbon pool by folate_Homo sapiens_hsa006702.21544894
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11638399
9Base excision repair_Homo sapiens_hsa034102.06727014
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86068775
11Chronic myeloid leukemia_Homo sapiens_hsa052201.79688641
12MicroRNAs in cancer_Homo sapiens_hsa052061.66980402
13Lysine degradation_Homo sapiens_hsa003101.65545407
14Non-homologous end-joining_Homo sapiens_hsa034501.58686503
15Notch signaling pathway_Homo sapiens_hsa043301.52050310
16Colorectal cancer_Homo sapiens_hsa052101.51388007
17Homologous recombination_Homo sapiens_hsa034401.48862116
18mTOR signaling pathway_Homo sapiens_hsa041501.46343460
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45286103
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44592261
21Nucleotide excision repair_Homo sapiens_hsa034201.44394540
22Basal cell carcinoma_Homo sapiens_hsa052171.43761820
23Viral carcinogenesis_Homo sapiens_hsa052031.43326206
24HTLV-I infection_Homo sapiens_hsa051661.42549224
25Adherens junction_Homo sapiens_hsa045201.36203649
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36009087
27Fanconi anemia pathway_Homo sapiens_hsa034601.35700985
28Small cell lung cancer_Homo sapiens_hsa052221.34256284
29Non-small cell lung cancer_Homo sapiens_hsa052231.32064481
30RNA degradation_Homo sapiens_hsa030181.30746769
31p53 signaling pathway_Homo sapiens_hsa041151.28073193
32Endometrial cancer_Homo sapiens_hsa052131.27113878
33Biosynthesis of amino acids_Homo sapiens_hsa012301.27010937
34Pentose phosphate pathway_Homo sapiens_hsa000301.25852958
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24305757
36Hippo signaling pathway_Homo sapiens_hsa043901.22582318
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22408604
38Oocyte meiosis_Homo sapiens_hsa041141.19646241
39Viral myocarditis_Homo sapiens_hsa054161.17702399
40Acute myeloid leukemia_Homo sapiens_hsa052211.13149695
41Thyroid cancer_Homo sapiens_hsa052161.12375729
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12193978
43Pancreatic cancer_Homo sapiens_hsa052121.10006646
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.09951457
45Epstein-Barr virus infection_Homo sapiens_hsa051691.09479902
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09470109
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08246711
48Proteoglycans in cancer_Homo sapiens_hsa052051.07876113
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.06975760
50Antigen processing and presentation_Homo sapiens_hsa046121.04259829
51B cell receptor signaling pathway_Homo sapiens_hsa046621.02228785
52Glioma_Homo sapiens_hsa052140.99942661
53Hedgehog signaling pathway_Homo sapiens_hsa043400.96760524
54Prostate cancer_Homo sapiens_hsa052150.95813911
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92996977
56Hepatitis B_Homo sapiens_hsa051610.92811669
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92332205
58* Herpes simplex infection_Homo sapiens_hsa051680.90449537
59Primary immunodeficiency_Homo sapiens_hsa053400.89760134
60Prion diseases_Homo sapiens_hsa050200.88636962
61Inositol phosphate metabolism_Homo sapiens_hsa005620.87985230
62Pathways in cancer_Homo sapiens_hsa052000.87878200
63Fructose and mannose metabolism_Homo sapiens_hsa000510.86672977
64Renal cell carcinoma_Homo sapiens_hsa052110.85495796
65TGF-beta signaling pathway_Homo sapiens_hsa043500.85377616
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83878010
67Wnt signaling pathway_Homo sapiens_hsa043100.83230115
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.83003195
69Bladder cancer_Homo sapiens_hsa052190.82258011
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81982476
71T cell receptor signaling pathway_Homo sapiens_hsa046600.80641119
72Focal adhesion_Homo sapiens_hsa045100.80291545
73Choline metabolism in cancer_Homo sapiens_hsa052310.80265971
74Systemic lupus erythematosus_Homo sapiens_hsa053220.77846038
75VEGF signaling pathway_Homo sapiens_hsa043700.74592695
76FoxO signaling pathway_Homo sapiens_hsa040680.73977960
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73554539
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.72965677
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72919390
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72608518
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72541656
82Melanogenesis_Homo sapiens_hsa049160.72441041
83RNA polymerase_Homo sapiens_hsa030200.72154909
84Apoptosis_Homo sapiens_hsa042100.71610223
85HIF-1 signaling pathway_Homo sapiens_hsa040660.71220295
86Dorso-ventral axis formation_Homo sapiens_hsa043200.70361139
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.68552631
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67496795
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64504155
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63697021
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63263674
92Toxoplasmosis_Homo sapiens_hsa051450.60973252
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60862495
94GnRH signaling pathway_Homo sapiens_hsa049120.60639369
95Long-term potentiation_Homo sapiens_hsa047200.60616236
96AMPK signaling pathway_Homo sapiens_hsa041520.59652054
97Estrogen signaling pathway_Homo sapiens_hsa049150.59572397
98Glucagon signaling pathway_Homo sapiens_hsa049220.59472820
99Vitamin B6 metabolism_Homo sapiens_hsa007500.57990901
100Basal transcription factors_Homo sapiens_hsa030220.57176741
101Pyrimidine metabolism_Homo sapiens_hsa002400.56996921
102Fatty acid biosynthesis_Homo sapiens_hsa000610.56966444
103Insulin signaling pathway_Homo sapiens_hsa049100.56658502
104Insulin resistance_Homo sapiens_hsa049310.55798682
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.55600869
106N-Glycan biosynthesis_Homo sapiens_hsa005100.55575977
107Platelet activation_Homo sapiens_hsa046110.55556380
108Shigellosis_Homo sapiens_hsa051310.55096695
109ErbB signaling pathway_Homo sapiens_hsa040120.54879506
110Melanoma_Homo sapiens_hsa052180.54242453
111Measles_Homo sapiens_hsa051620.54050307
112Carbon metabolism_Homo sapiens_hsa012000.52918112
113Other glycan degradation_Homo sapiens_hsa005110.52259199
114Tight junction_Homo sapiens_hsa045300.50510522
115Alcoholism_Homo sapiens_hsa050340.50289412
116Hepatitis C_Homo sapiens_hsa051600.49023921
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48496364
118Prolactin signaling pathway_Homo sapiens_hsa049170.47970646
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46488009
120Influenza A_Homo sapiens_hsa051640.46103781
121Rap1 signaling pathway_Homo sapiens_hsa040150.45653925
122MAPK signaling pathway_Homo sapiens_hsa040100.44821205
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43698602
124Osteoclast differentiation_Homo sapiens_hsa043800.42601658
125Type II diabetes mellitus_Homo sapiens_hsa049300.42381676
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.39947587

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