HCFC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.70554557
2doxorubicin metabolic process (GO:0044598)5.70554557
3daunorubicin metabolic process (GO:0044597)5.70554557
4cilium or flagellum-dependent cell motility (GO:0001539)4.66462549
5response to pheromone (GO:0019236)4.10961345
6piRNA metabolic process (GO:0034587)3.97286376
7sperm motility (GO:0030317)3.88750941
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.73885444
9acrosome assembly (GO:0001675)3.66448281
10presynaptic membrane assembly (GO:0097105)3.57575464
11acrosome reaction (GO:0007340)3.56632401
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.46367066
13male meiosis (GO:0007140)3.44323771
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43762284
15positive regulation of glycolytic process (GO:0045821)3.43643367
16motile cilium assembly (GO:0044458)3.42592559
17regulation of glucokinase activity (GO:0033131)3.39511202
18regulation of hexokinase activity (GO:1903299)3.39511202
19regulation of type B pancreatic cell apoptotic process (GO:2000674)3.38237456
20Golgi to endosome transport (GO:0006895)3.37506995
21DNA methylation involved in gamete generation (GO:0043046)3.33861923
22urinary tract smooth muscle contraction (GO:0014848)3.30964956
23macroautophagy (GO:0016236)3.29120196
24auditory receptor cell stereocilium organization (GO:0060088)3.28671315
25epithelial cilium movement (GO:0003351)3.27926619
26cerebral cortex radially oriented cell migration (GO:0021799)3.25447083
27aminoglycoside antibiotic metabolic process (GO:0030647)3.22980840
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22828878
29presynaptic membrane organization (GO:0097090)3.21430889
30startle response (GO:0001964)3.20845369
31inositol phosphate catabolic process (GO:0071545)3.20169294
32glutamate receptor signaling pathway (GO:0007215)3.14068947
33fusion of sperm to egg plasma membrane (GO:0007342)3.12933840
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07141175
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06751482
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05287210
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.02188988
38inner ear receptor stereocilium organization (GO:0060122)3.01841956
39establishment of nucleus localization (GO:0040023)2.97718115
40calcium ion-dependent exocytosis (GO:0017156)2.97206252
41protein targeting to Golgi (GO:0000042)2.94341269
42cellular ketone body metabolic process (GO:0046950)2.94128148
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93501959
44synaptic transmission, glutamatergic (GO:0035249)2.92987875
45neuron cell-cell adhesion (GO:0007158)2.91128333
46intra-Golgi vesicle-mediated transport (GO:0006891)2.89466736
47insulin secretion (GO:0030073)2.89053684
48early endosome to late endosome transport (GO:0045022)2.88604455
49regulation of energy homeostasis (GO:2000505)2.87325748
50establishment of protein localization to Golgi (GO:0072600)2.86001227
51plasma membrane fusion (GO:0045026)2.84143497
52vocalization behavior (GO:0071625)2.83554154
53brain morphogenesis (GO:0048854)2.83343612
54positive regulation of protein autophosphorylation (GO:0031954)2.83177169
55multicellular organism reproduction (GO:0032504)2.82702317
56ketone body metabolic process (GO:1902224)2.81719097
57detection of calcium ion (GO:0005513)2.80670101
58retrograde transport, vesicle recycling within Golgi (GO:0000301)2.80139416
59cilium movement (GO:0003341)2.77848108
60protein localization to synapse (GO:0035418)2.77648163
61neuron remodeling (GO:0016322)2.76039303
62regulation of glutamate receptor signaling pathway (GO:1900449)2.76017471
63protein localization to cilium (GO:0061512)2.75945564
64negative regulation of neurotransmitter transport (GO:0051589)2.75138970
65ER overload response (GO:0006983)2.74646097
66regulation of synaptic vesicle exocytosis (GO:2000300)2.74224248
67calcium ion import (GO:0070509)2.73871371
68axonemal dynein complex assembly (GO:0070286)2.71357823
69synaptic vesicle endocytosis (GO:0048488)2.71039690
70nitric oxide mediated signal transduction (GO:0007263)2.70239070
71nucleus localization (GO:0051647)2.70149886
72protein localization to Golgi apparatus (GO:0034067)2.69017777
73phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68147137
74inositol phosphate dephosphorylation (GO:0046855)2.68147137
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68138334
76keratinocyte development (GO:0003334)2.67740217
77sequestering of extracellular ligand from receptor (GO:0035581)2.67125840
78intraciliary transport (GO:0042073)2.66732295
79neuron-neuron synaptic transmission (GO:0007270)2.63173955
80negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62606186
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61892142
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61363033
83long-term synaptic potentiation (GO:0060291)2.59770704
84COPII vesicle coating (GO:0048208)2.57466626
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56563040
86regulation of synaptic vesicle transport (GO:1902803)2.55512804
87polyol catabolic process (GO:0046174)2.55223175
88spermatid development (GO:0007286)2.54989515
89postsynaptic membrane organization (GO:0001941)2.54362398
90regulation of cilium movement (GO:0003352)2.53806855
91nerve growth factor signaling pathway (GO:0038180)2.53342130
92prenylation (GO:0097354)2.53116218
93protein prenylation (GO:0018342)2.53116218
94glycosphingolipid biosynthetic process (GO:0006688)2.52847255
95positive regulation of meiotic cell cycle (GO:0051446)2.52209957
96positive regulation of cardiac muscle hypertrophy (GO:0010613)2.52207697
97positive regulation of muscle hypertrophy (GO:0014742)2.52207697
98adaptation of signaling pathway (GO:0023058)2.51521613
99positive regulation of neurotransmitter secretion (GO:0001956)2.51448482
100central nervous system projection neuron axonogenesis (GO:0021952)2.50938944
101proline transport (GO:0015824)2.50509120
102cyclic nucleotide catabolic process (GO:0009214)2.50043621
103gamma-aminobutyric acid signaling pathway (GO:0007214)2.48175322
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47247676
105endocrine pancreas development (GO:0031018)2.46418719
106cell wall macromolecule metabolic process (GO:0044036)2.46326394
107cell wall macromolecule catabolic process (GO:0016998)2.46326394
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46297281
109negative regulation of hormone biosynthetic process (GO:0032353)2.45649243
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.44727372
111membrane depolarization during action potential (GO:0086010)2.43826295
112negative regulation of neurotransmitter secretion (GO:0046929)2.43282134
113fibroblast migration (GO:0010761)2.41962328
114cAMP catabolic process (GO:0006198)2.40743608
115regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40641061
116vesicle docking (GO:0048278)2.40488520
117glutamate secretion (GO:0014047)2.39994800
118regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.39296469
119neurotransmitter-gated ion channel clustering (GO:0072578)2.38733958
120signal peptide processing (GO:0006465)2.38628651
121synaptic vesicle exocytosis (GO:0016079)2.37944434
122lactate metabolic process (GO:0006089)2.37684913
123inner ear receptor cell development (GO:0060119)2.37401203
124neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37154356
125sperm-egg recognition (GO:0035036)2.36988968
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.36824811
127regulation of protein glycosylation (GO:0060049)2.36022415
128positive regulation of meiosis (GO:0045836)2.34955490
129locomotory exploration behavior (GO:0035641)2.34743307
130prostate gland growth (GO:0060736)2.33361997
131innervation (GO:0060384)2.33071014
132vesicle docking involved in exocytosis (GO:0006904)2.32949755
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32926497
134vascular smooth muscle contraction (GO:0014829)2.32528097
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32454462
136positive regulation of growth hormone secretion (GO:0060124)2.32387584
137extracellular negative regulation of signal transduction (GO:1900116)2.30456788
138extracellular regulation of signal transduction (GO:1900115)2.30456788
139parental behavior (GO:0060746)2.29605624
140protein K11-linked deubiquitination (GO:0035871)2.28996500
141dentate gyrus development (GO:0021542)2.28512350
142neuron recognition (GO:0008038)2.27989554
143regulation of postsynaptic membrane potential (GO:0060078)2.27123591
144gamma-aminobutyric acid transport (GO:0015812)2.25031163
145regulation of cell communication by electrical coupling (GO:0010649)2.24923074
146type B pancreatic cell proliferation (GO:0044342)2.24820542
147synaptonemal complex organization (GO:0070193)2.24305466
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24065160
149protein polyglutamylation (GO:0018095)2.23682653
150axonal fasciculation (GO:0007413)2.21362075
151serotonin receptor signaling pathway (GO:0007210)2.21097495
152regulation of pigment cell differentiation (GO:0050932)2.21022958
153vesicle transport along microtubule (GO:0047496)2.19969206
154regulation of sarcomere organization (GO:0060297)2.19094291
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18266089
156C4-dicarboxylate transport (GO:0015740)2.17250007
157positive regulation of insulin secretion (GO:0032024)2.17145299
158renal tubule morphogenesis (GO:0061333)2.16642889
159negative regulation of NF-kappaB import into nucleus (GO:0042347)2.16136172
160sphingoid metabolic process (GO:0046519)2.14355247
161positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.13600218
162smooth muscle tissue development (GO:0048745)2.13275366
163coenzyme catabolic process (GO:0009109)2.10635271
164negative regulation of hormone metabolic process (GO:0032351)2.09658803
165regulation of dendritic spine development (GO:0060998)2.09637091
166cellular response to ethanol (GO:0071361)2.09337933
167pancreas development (GO:0031016)2.09239590
168smooth muscle contraction (GO:0006939)2.08878017
169response to redox state (GO:0051775)2.08794153
170phospholipid dephosphorylation (GO:0046839)2.08455669
171interkinetic nuclear migration (GO:0022027)2.08335107
172central nervous system neuron axonogenesis (GO:0021955)2.07997693
173positive regulation of peptide hormone secretion (GO:0090277)2.06797467
174positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.05442969
175peptide hormone secretion (GO:0030072)2.04738655
176nucleobase catabolic process (GO:0046113)2.03058953
177dendritic spine morphogenesis (GO:0060997)2.02741920
178phosphatidylinositol dephosphorylation (GO:0046856)2.01298826
179peptide secretion (GO:0002790)2.01235540
180cellular response to leptin stimulus (GO:0044320)2.00320625
181negative regulation of acute inflammatory response (GO:0002674)2.00083385
182regulation of relaxation of muscle (GO:1901077)1.99984510
183positive regulation of phosphatase activity (GO:0010922)1.99383834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62880902
2GBX2_23144817_ChIP-Seq_PC3_Human4.00706964
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35990584
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76079578
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68388162
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50248631
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41567531
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39409963
9TAF15_26573619_Chip-Seq_HEK293_Human2.17510405
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04125689
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00062820
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98409375
13P300_19829295_ChIP-Seq_ESCs_Human1.97149597
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94595464
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93995186
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93782409
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92493955
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89651411
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88260752
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.85505916
21SMAD4_21799915_ChIP-Seq_A2780_Human1.85262943
22FUS_26573619_Chip-Seq_HEK293_Human1.79757621
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.79585774
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78342499
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76298095
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75407597
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.72401816
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71555649
29VDR_22108803_ChIP-Seq_LS180_Human1.70669514
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68609342
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.65728929
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.65598675
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.65556293
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.65249223
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.64824039
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61504477
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.61341415
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56948565
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56948565
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56268220
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55916989
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55157975
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54938833
44REST_21632747_ChIP-Seq_MESCs_Mouse1.54827936
45STAT3_23295773_ChIP-Seq_U87_Human1.53576912
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53401746
47* TCF4_23295773_ChIP-Seq_U87_Human1.52181520
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.51975353
49DROSHA_22980978_ChIP-Seq_HELA_Human1.51822678
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50374928
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49808198
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48805077
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.48519229
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48268732
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48268732
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46895678
57P53_22387025_ChIP-Seq_ESCs_Mouse1.46860521
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46252691
59AR_25329375_ChIP-Seq_VCAP_Human1.44072748
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41933098
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.40589037
62ZNF274_21170338_ChIP-Seq_K562_Hela1.40442003
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39765262
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39765262
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39533389
66* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39415549
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.39249683
68RNF2_27304074_Chip-Seq_NSC_Mouse1.38740187
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.38735756
70ER_23166858_ChIP-Seq_MCF-7_Human1.38116306
71IGF1R_20145208_ChIP-Seq_DFB_Human1.38046113
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37798694
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37420689
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.36932859
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36574773
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36140561
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35856096
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35667409
79AHR_22903824_ChIP-Seq_MCF-7_Human1.34989691
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34362687
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34138035
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.33763121
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.33741234
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33388004
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32235569
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32142064
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32025310
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.31883150
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30088246
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.29861229
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28523772
92CJUN_26792858_Chip-Seq_BT549_Human1.27584626
93* FLI1_21867929_ChIP-Seq_TH2_Mouse1.26294829
94BCAT_22108803_ChIP-Seq_LS180_Human1.24272851
95EWS_26573619_Chip-Seq_HEK293_Human1.23676573
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23540563
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22917547
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.22555792
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21997577
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21513259
101P300_18555785_Chip-Seq_ESCs_Mouse1.21375021
102RUNX2_22187159_ChIP-Seq_PCA_Human1.19651644
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19457127
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.17734837
105KDM2B_26808549_Chip-Seq_REH_Human1.17653181
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.17471068
107* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17215965
108AR_21572438_ChIP-Seq_LNCaP_Human1.16945664
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.15707632
110CDX2_22108803_ChIP-Seq_LS180_Human1.15369968
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14766204
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.14342170
113PU1_27457419_Chip-Seq_LIVER_Mouse1.14017270
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13585004
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13151750
116CBP_20019798_ChIP-Seq_JUKART_Human1.13151750
117TP53_18474530_ChIP-ChIP_U2OS_Human1.12752963
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11250111
119TP53_16413492_ChIP-PET_HCT116_Human1.10751390
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09280956
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.07968082
122BRD4_25478319_ChIP-Seq_HGPS_Human1.07491916
123TCF4_22108803_ChIP-Seq_LS180_Human1.06736832
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05417997
125* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04782317
126* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03530891
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.03253843
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02999853
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.02510253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.56841101
2MP0005410_abnormal_fertilization3.52355829
3MP0003880_abnormal_central_pattern3.03265672
4MP0005646_abnormal_pituitary_gland3.00096857
5MP0009780_abnormal_chondrocyte_physiolo2.89718393
6MP0010234_abnormal_vibrissa_follicle2.80201299
7MP0003195_calcinosis2.53201805
8MP0003635_abnormal_synaptic_transmissio2.43246657
9MP0003787_abnormal_imprinting2.34741754
10MP0003122_maternal_imprinting2.29196783
11MP0002063_abnormal_learning/memory/cond2.28354513
12MP0005645_abnormal_hypothalamus_physiol2.25162220
13MP0009745_abnormal_behavioral_response2.24815704
14MP0009046_muscle_twitch2.17220010
15MP0003183_abnormal_peptide_metabolism2.16951290
16MP0002572_abnormal_emotion/affect_behav2.15988893
17MP0008877_abnormal_DNA_methylation2.12772736
18MP0010386_abnormal_urinary_bladder2.07974979
19MP0006054_spinal_hemorrhage2.02876820
20MP0002064_seizures1.99778023
21MP0001968_abnormal_touch/_nociception1.96393938
22MP0008438_abnormal_cutaneous_collagen1.88425318
23MP0002735_abnormal_chemical_nociception1.87200465
24MP0004270_analgesia1.86620193
25MP0005171_absent_coat_pigmentation1.86350306
26MP0001188_hyperpigmentation1.85972472
27MP0001486_abnormal_startle_reflex1.84756536
28MP0002736_abnormal_nociception_after1.83863790
29MP0004742_abnormal_vestibular_system1.83787070
30MP0002837_dystrophic_cardiac_calcinosis1.82676858
31MP0000749_muscle_degeneration1.82091512
32MP0002638_abnormal_pupillary_reflex1.80330547
33MP0003698_abnormal_male_reproductive1.79395495
34MP0001984_abnormal_olfaction1.77172534
35MP0001502_abnormal_circadian_rhythm1.74314885
36MP0000678_abnormal_parathyroid_gland1.72300190
37MP0009697_abnormal_copulation1.72265969
38MP0004134_abnormal_chest_morphology1.69303519
39MP0000013_abnormal_adipose_tissue1.67609842
40MP0002272_abnormal_nervous_system1.66543461
41MP0005275_abnormal_skin_tensile1.64891809
42MP0000569_abnormal_digit_pigmentation1.64112532
43MP0006276_abnormal_autonomic_nervous1.61649474
44MP0002067_abnormal_sensory_capabilities1.61206934
45MP0000778_abnormal_nervous_system1.60019998
46MP0010678_abnormal_skin_adnexa1.55475321
47MP0001501_abnormal_sleep_pattern1.55178144
48MP0005084_abnormal_gallbladder_morpholo1.54000155
49MP0002102_abnormal_ear_morphology1.53197038
50MP0002928_abnormal_bile_duct1.52189469
51MP0002557_abnormal_social/conspecific_i1.46648744
52MP0005503_abnormal_tendon_morphology1.44812236
53MP0004885_abnormal_endolymph1.39729128
54MP0003121_genomic_imprinting1.37083913
55MP0002734_abnormal_mechanical_nocicepti1.34485976
56MP0001440_abnormal_grooming_behavior1.33732575
57MP0002139_abnormal_hepatobiliary_system1.30981712
58MP0004510_myositis1.30931206
59MP0004924_abnormal_behavior1.30664574
60MP0005386_behavior/neurological_phenoty1.30664574
61MP0000751_myopathy1.28809593
62MP0005551_abnormal_eye_electrophysiolog1.27832746
63MP0002184_abnormal_innervation1.25724039
64MP0008569_lethality_at_weaning1.24779334
65MP0008004_abnormal_stomach_pH1.23067350
66MP0003283_abnormal_digestive_organ1.22374526
67MP0001299_abnormal_eye_distance/1.21712534
68MP0003879_abnormal_hair_cell1.21526171
69MP0001958_emphysema1.21077540
70MP0000003_abnormal_adipose_tissue1.19912948
71MP0001929_abnormal_gametogenesis1.17552892
72MP0000631_abnormal_neuroendocrine_gland1.16595709
73MP0005367_renal/urinary_system_phenotyp1.16031559
74MP0000516_abnormal_urinary_system1.16031559
75MP0004036_abnormal_muscle_relaxation1.13955697
76MP0004811_abnormal_neuron_physiology1.08685475
77MP0002168_other_aberrant_phenotype1.08524584
78MP0002295_abnormal_pulmonary_circulatio1.08357845
79MP0001661_extended_life_span1.07703285
80MP0003252_abnormal_bile_duct1.06599101
81MP0001529_abnormal_vocalization1.05176662
82MP0004084_abnormal_cardiac_muscle1.05122652
83MP0004145_abnormal_muscle_electrophysio1.05032108
84MP0005248_abnormal_Harderian_gland1.05029200
85MP0004043_abnormal_pH_regulation1.04481191
86MP0010352_gastrointestinal_tract_polyps1.03670545
87MP0002693_abnormal_pancreas_physiology1.03299658
88MP0006072_abnormal_retinal_apoptosis1.02040600
89MP0002332_abnormal_exercise_endurance1.01499585
90MP0003279_aneurysm1.01413265
91MP0003868_abnormal_feces_composition1.01075129
92MP0003656_abnormal_erythrocyte_physiolo1.00035318
93MP0000566_synostosis0.99264404
94MP0002127_abnormal_cardiovascular_syste0.98363451
95MP0005253_abnormal_eye_physiology0.97292317
96MP0002909_abnormal_adrenal_gland0.96119377
97MP0004142_abnormal_muscle_tone0.95993350
98MP0005423_abnormal_somatic_nervous0.95309664
99MP0002269_muscular_atrophy0.92954837
100MP0003045_fibrosis0.92077300
101MP0010329_abnormal_lipoprotein_level0.91975834
102MP0009250_abnormal_appendicular_skeleto0.91854061
103MP0006292_abnormal_olfactory_placode0.91633016
104MP0003633_abnormal_nervous_system0.90925636
105MP0004215_abnormal_myocardial_fiber0.90620441
106MP0004085_abnormal_heartbeat0.90359262
107MP0002882_abnormal_neuron_morphology0.89554742
108MP0005409_darkened_coat_color0.89409689
109MP0001944_abnormal_pancreas_morphology0.89208775
110MP0009384_cardiac_valve_regurgitation0.89067988
111MP0002876_abnormal_thyroid_physiology0.88874975
112MP0001970_abnormal_pain_threshold0.88841021
113MP0005174_abnormal_tail_pigmentation0.87929907
114MP0000383_abnormal_hair_follicle0.87766072
115MP0000015_abnormal_ear_pigmentation0.87344630
116MP0002009_preneoplasia0.87002352
117MP0000230_abnormal_systemic_arterial0.86527785
118MP0001963_abnormal_hearing_physiology0.84355784
119MP0002078_abnormal_glucose_homeostasis0.83698501
120MP0008775_abnormal_heart_ventricle0.83164023
121MP0002210_abnormal_sex_determination0.82880358
122MP0002163_abnormal_gland_morphology0.82684136
123MP0005187_abnormal_penis_morphology0.82456538
124MP0004484_altered_response_of0.82316702
125MP0001756_abnormal_urination0.81173490
126MP0000955_abnormal_spinal_cord0.80808527
127MP0002066_abnormal_motor_capabilities/c0.80524407
128MP0002108_abnormal_muscle_morphology0.79254392
129MP0005369_muscle_phenotype0.77316865
130MP0001542_abnormal_bone_strength0.77225127
131MP0002161_abnormal_fertility/fecundity0.76022520
132MP0003385_abnormal_body_wall0.75343536
133MP0001177_atelectasis0.75142326
134MP0002166_altered_tumor_susceptibility0.74558664
135MP0003631_nervous_system_phenotype0.74156728
136MP0010368_abnormal_lymphatic_system0.74103852
137MP0003950_abnormal_plasma_membrane0.72872607
138MP0000427_abnormal_hair_cycle0.72776484
139MP0001905_abnormal_dopamine_level0.71606739
140MP0001986_abnormal_taste_sensitivity0.71006715
141MP0002733_abnormal_thermal_nociception0.70295059
142MP0002896_abnormal_bone_mineralization0.70184951
143MP0002152_abnormal_brain_morphology0.69978751
144MP0005379_endocrine/exocrine_gland_phen0.68701741
145MP0005257_abnormal_intraocular_pressure0.67085108
146MP0005220_abnormal_exocrine_pancreas0.65991851
147MP0004233_abnormal_muscle_weight0.65096099
148MP0005620_abnormal_muscle_contractility0.64470520

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.17006660
2Absent/shortened dynein arms (HP:0200106)6.17006660
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77911930
4Focal motor seizures (HP:0011153)4.68591405
5Abnormal respiratory motile cilium physiology (HP:0012261)3.77734004
6Abnormal respiratory motile cilium morphology (HP:0005938)3.52684294
7Abnormal respiratory epithelium morphology (HP:0012253)3.52684294
8Hyperventilation (HP:0002883)3.44633524
9Abnormal ciliary motility (HP:0012262)3.43780285
10Nephronophthisis (HP:0000090)3.38159164
11Epileptic encephalopathy (HP:0200134)3.36970253
12Hypothermia (HP:0002045)3.27343575
13Calf muscle hypertrophy (HP:0008981)3.27271418
14Hemiparesis (HP:0001269)3.18209392
15Rhinitis (HP:0012384)3.13554538
16Absent eyebrow (HP:0002223)3.10825214
17Protruding tongue (HP:0010808)3.03952835
18Congenital sensorineural hearing impairment (HP:0008527)3.03739245
19Hyperglycemia (HP:0003074)2.97638786
20Hypoglycemic coma (HP:0001325)2.96978115
21Muscle hypertrophy of the lower extremities (HP:0008968)2.96574930
22Ketoacidosis (HP:0001993)2.91795337
23Chronic hepatic failure (HP:0100626)2.90342121
24Febrile seizures (HP:0002373)2.88981655
25Abnormality of the calf musculature (HP:0001430)2.86221732
26Bell-shaped thorax (HP:0001591)2.85052219
27Tubulointerstitial nephritis (HP:0001970)2.84855875
28Metaphyseal dysplasia (HP:0100255)2.78926834
29Dysdiadochokinesis (HP:0002075)2.75717963
30Abnormality of the renal medulla (HP:0100957)2.72892146
31Thyroid carcinoma (HP:0002890)2.70788113
32Molar tooth sign on MRI (HP:0002419)2.62725763
33Abnormality of midbrain morphology (HP:0002418)2.62725763
34Medial flaring of the eyebrow (HP:0010747)2.60382568
35Hamartoma of the eye (HP:0010568)2.58205124
36Blue irides (HP:0000635)2.54420152
37Atonic seizures (HP:0010819)2.52330498
38Retinal dysplasia (HP:0007973)2.49751098
39Fetal akinesia sequence (HP:0001989)2.47764443
40Intention tremor (HP:0002080)2.45535601
41Large for gestational age (HP:0001520)2.45250974
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44987342
43Progressive cerebellar ataxia (HP:0002073)2.42431363
44Focal seizures (HP:0007359)2.41205253
45Neoplasm of the heart (HP:0100544)2.40203458
46Thyroiditis (HP:0100646)2.37044606
47Hematochezia (HP:0002573)2.36786708
48Unilateral renal agenesis (HP:0000122)2.34230756
49Absent speech (HP:0001344)2.32814673
50Abnormal hair whorl (HP:0010721)2.32451838
51Muscle fiber inclusion bodies (HP:0100299)2.32194183
52Nemaline bodies (HP:0003798)2.30735525
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.30422440
54Fibular hypoplasia (HP:0003038)2.24867998
55Conjugated hyperbilirubinemia (HP:0002908)2.23842963
56Striae distensae (HP:0001065)2.22356348
57Drooling (HP:0002307)2.22064305
58Excessive salivation (HP:0003781)2.22064305
59Fair hair (HP:0002286)2.21960497
60Widely spaced teeth (HP:0000687)2.21852223
61Genital tract atresia (HP:0001827)2.21840306
62Hypoglycemic seizures (HP:0002173)2.19768254
63Abnormality of vitamin B metabolism (HP:0004340)2.18260559
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.17939202
65Nephrogenic diabetes insipidus (HP:0009806)2.16843244
66Menstrual irregularities (HP:0000858)2.14509946
67Pheochromocytoma (HP:0002666)2.13660965
68Gaze-evoked nystagmus (HP:0000640)2.13566448
69Follicular hyperkeratosis (HP:0007502)2.12917729
70Absence seizures (HP:0002121)2.12725046
71Pancreatic fibrosis (HP:0100732)2.12318227
72Type 1 muscle fiber predominance (HP:0003803)2.11608582
73Mitral stenosis (HP:0001718)2.09754915
74Decreased central vision (HP:0007663)2.09261322
75Generalized hypopigmentation of hair (HP:0011358)2.08278926
76Subaortic stenosis (HP:0001682)2.07846120
77Abnormality of the left ventricular outflow tract (HP:0011103)2.07846120
78Abnormality of incisor morphology (HP:0011063)2.07049681
79True hermaphroditism (HP:0010459)2.06419458
80Aplasia/Hypoplasia of the lens (HP:0008063)2.06328081
81Renal dysplasia (HP:0000110)2.04928009
82Methylmalonic acidemia (HP:0002912)2.03554927
83Epileptiform EEG discharges (HP:0011182)2.02142211
84Distal arthrogryposis (HP:0005684)2.01653186
85Abnormality of the renal cortex (HP:0011035)2.01288133
86Symptomatic seizures (HP:0011145)1.98524865
87Hyperphosphatemia (HP:0002905)1.97174846
88Type II lissencephaly (HP:0007260)1.97036924
89Bundle branch block (HP:0011710)1.96998576
90Papillary thyroid carcinoma (HP:0002895)1.96673624
91Frequent falls (HP:0002359)1.94407478
92Delayed gross motor development (HP:0002194)1.92968749
93Downturned corners of mouth (HP:0002714)1.92118905
94Volvulus (HP:0002580)1.91759073
95Dialeptic seizures (HP:0011146)1.91238912
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.90878867
97Vaginal atresia (HP:0000148)1.90712672
98Congenital primary aphakia (HP:0007707)1.87934087
99Gait imbalance (HP:0002141)1.87662280
100Ketosis (HP:0001946)1.86552671
101Short tibia (HP:0005736)1.86312956
102White forelock (HP:0002211)1.85496394
103Proximal amyotrophy (HP:0007126)1.85245186
104Abnormality of the musculature of the pelvis (HP:0001469)1.85007009
105Abnormality of the hip-girdle musculature (HP:0001445)1.85007009
106Postaxial foot polydactyly (HP:0001830)1.84157420
107Broad-based gait (HP:0002136)1.82576850
108Abnormality of endocrine pancreas physiology (HP:0012093)1.81681245
109Abnormality of the pancreatic islet cells (HP:0006476)1.81681245
110Abnormality of the astrocytes (HP:0100707)1.81615567
111Astrocytoma (HP:0009592)1.81615567
112Late onset (HP:0003584)1.81529100
113Abnormal pancreas size (HP:0012094)1.81241319
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.80681442
115Hypoplasia of the fovea (HP:0007750)1.80681442
116Postaxial hand polydactyly (HP:0001162)1.79560597
117EEG with generalized epileptiform discharges (HP:0011198)1.77841957
118Nephropathy (HP:0000112)1.77809200
119Poor coordination (HP:0002370)1.77449626
120Enlarged penis (HP:0000040)1.77320879
121Neuroendocrine neoplasm (HP:0100634)1.76939549
122Truncal ataxia (HP:0002078)1.76224162
123Increased CSF protein (HP:0002922)1.75804845
124Hyperkalemia (HP:0002153)1.75061098
125Long clavicles (HP:0000890)1.74998577
126Tubular atrophy (HP:0000092)1.74485677
127Glucose intolerance (HP:0000833)1.74107035
128Infertility (HP:0000789)1.73992021
129Tubulointerstitial abnormality (HP:0001969)1.73617069
130Generalized tonic-clonic seizures (HP:0002069)1.73163317
131Left ventricular hypertrophy (HP:0001712)1.72534970
132Exocrine pancreatic insufficiency (HP:0001738)1.72287264
133Neoplasm of the adrenal cortex (HP:0100641)1.71814336
134EMG: myopathic abnormalities (HP:0003458)1.71081729
135Insulin-resistant diabetes mellitus (HP:0000831)1.70534661
136Intestinal atresia (HP:0011100)1.70318110
137Renal cortical cysts (HP:0000803)1.70168378
138Absent frontal sinuses (HP:0002688)1.69343674
139Microglossia (HP:0000171)1.69312105
140Intellectual disability, moderate (HP:0002342)1.69255835
141Round ear (HP:0100830)1.69153362
142Patchy hypopigmentation of hair (HP:0011365)1.68507543
143Abnormality of the right ventricle (HP:0001707)1.68072882
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.66437385
145Abnormality of vitamin metabolism (HP:0100508)1.65929908
146Abnormality of dental color (HP:0011073)1.65806866
147Abnormality of the fovea (HP:0000493)1.65615443
148Open mouth (HP:0000194)1.64368058
149Chronic bronchitis (HP:0004469)1.63977253
150Aplasia/Hypoplasia of the fibula (HP:0006492)1.63384423
151Congenital hepatic fibrosis (HP:0002612)1.61981109
152Bradycardia (HP:0001662)1.61500261
153Irregular vertebral endplates (HP:0003301)1.60351936
154Atrial fibrillation (HP:0005110)1.60348142
155Cystic liver disease (HP:0006706)1.59592116
156Truncal obesity (HP:0001956)1.59554718
157Lissencephaly (HP:0001339)1.58892910
158Abnormality of the vertebral endplates (HP:0005106)1.58818786
159Flattened epiphyses (HP:0003071)1.58195279
160Hyperinsulinemic hypoglycemia (HP:0000825)1.58180808
161Segmental peripheral demyelination/remyelination (HP:0003481)1.57517573
162Hip dysplasia (HP:0001385)1.56717226
163Hypsarrhythmia (HP:0002521)1.55912411
164Hypoplastic ischia (HP:0003175)1.54891439
165Dyschromatopsia (HP:0007641)1.54796516
166Inability to walk (HP:0002540)1.54706195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.94729775
2SIK33.59160543
3NTRK33.51218079
4EPHA42.82225500
5MAP2K72.65406087
6INSRR2.59951091
7PRPF4B2.59742022
8MAP3K42.39609652
9PDK32.29582316
10PDK42.29582316
11SGK22.23418977
12PLK22.23133217
13PHKG21.92476132
14PHKG11.92476132
15PTK2B1.88235050
16CDK81.76096280
17TRIM281.72832514
18MAP4K21.72097285
19RIPK41.70307787
20PRKD31.67259033
21NEK91.66090318
22SGK4941.64566952
23SGK2231.64566952
24TNIK1.60323404
25SGK31.58542583
26PDK21.52207822
27AKT31.49465618
28NUAK11.46213785
29TAOK31.44787330
30BMPR21.41242134
31EPHA31.41013368
32CAMK1G1.39264110
33WNK31.36531303
34MAPK131.34836053
35DAPK21.33316704
36CCNB11.31641625
37SIK11.29948327
38SIK21.29829845
39MAP2K41.28168931
40LATS11.25965183
41EIF2AK31.23343353
42BMPR1B1.21843118
43FRK1.17666310
44PNCK1.16913214
45NTRK21.16385776
46TXK1.15426334
47CSNK1G11.14426180
48YES11.11300064
49MYLK1.08228105
50MAP3K121.07693516
51ERBB31.07030016
52PIK3CA1.02515927
53ZAK1.01102754
54FGFR31.00405094
55STK38L0.99507921
56MINK10.99214986
57CAMKK20.97048929
58WNK40.96405420
59PIK3CG0.96013252
60WNK10.95987115
61STK30.92246756
62CDK30.91052506
63JAK10.88625423
64MST40.85565808
65ACVR1B0.84068610
66CAMK2A0.83275562
67PRKCE0.81945733
68MARK30.81111544
69OXSR10.81098887
70SGK10.80873822
71CSNK1G30.77710080
72NLK0.76338555
73CAMK1D0.75285665
74DMPK0.72599714
75KSR10.72173014
76STK240.71217769
77PRKCQ0.69914961
78MAP3K130.68864917
79BCR0.67711519
80STK380.67670389
81ADRBK20.67606712
82GRK10.66396626
83PRKCG0.65278586
84CAMK10.65232996
85PRKAA20.65111662
86CAMK40.64921955
87CSNK1A1L0.64460095
88RPS6KB10.64262126
89ROCK10.64258143
90DAPK10.63824369
91BRSK20.63606450
92CAMKK10.63600820
93CDK50.63442792
94PASK0.62404418
95OBSCN0.61558359
96MARK10.61396525
97CAMK2D0.56782428
98PRKCH0.55051233
99MUSK0.55001145
100BRAF0.54697219
101NEK60.54043471
102PAK30.53543546
103DYRK1A0.53022940
104MAP2K10.52977545
105MKNK20.52927818
106GRK70.52873897
107MAP3K20.52720604
108MARK20.51925807
109MAP3K140.51853758
110HIPK20.51634077
111FER0.50738929
112STK390.50643209
113STK110.50339461
114PRKG10.50157250
115CSNK1D0.48709713
116PDK10.45097042
117TEC0.44355363
118CDC42BPA0.43161971
119TESK10.42729225
120PDGFRB0.41605532
121DDR20.40910613
122PINK10.40625758
123TIE10.40464341
124TRPM70.39951854
125GSK3A0.39407444
126CAMK2B0.39276890
127PRKACB0.39103220
128TGFBR20.39095235
129PDGFRA0.38222376
130LIMK10.37924630
131RPS6KA20.37548685
132PRKD10.37231586
133PRKAA10.37081530
134PRKACA0.37075064
135ABL10.36822220
136IRAK10.36753047
137FGFR20.36747612
138NME10.35835579
139CSNK1G20.35387976
140BRD40.34405447
141RET0.33872942
142MAPK70.33614184
143ADRBK10.29608027
144PDPK10.29309332

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.18019602
2Circadian entrainment_Homo sapiens_hsa047132.46644780
3Long-term potentiation_Homo sapiens_hsa047202.36780150
4Amphetamine addiction_Homo sapiens_hsa050312.35786919
5Insulin secretion_Homo sapiens_hsa049112.31759256
6Butanoate metabolism_Homo sapiens_hsa006502.21734520
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19365877
8Morphine addiction_Homo sapiens_hsa050322.13268412
9Glutamatergic synapse_Homo sapiens_hsa047242.06379451
10Synaptic vesicle cycle_Homo sapiens_hsa047212.01946781
11Renin secretion_Homo sapiens_hsa049241.93645782
12Taste transduction_Homo sapiens_hsa047421.81671458
13GABAergic synapse_Homo sapiens_hsa047271.78645704
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78246552
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73049849
16Calcium signaling pathway_Homo sapiens_hsa040201.71477338
17Dopaminergic synapse_Homo sapiens_hsa047281.69124241
18Serotonergic synapse_Homo sapiens_hsa047261.62971556
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62313648
20Salivary secretion_Homo sapiens_hsa049701.61607455
21Olfactory transduction_Homo sapiens_hsa047401.46154495
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45997545
23Protein export_Homo sapiens_hsa030601.45500437
24Propanoate metabolism_Homo sapiens_hsa006401.45464312
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42841206
26Long-term depression_Homo sapiens_hsa047301.42223234
27Type II diabetes mellitus_Homo sapiens_hsa049301.41647664
28Sphingolipid metabolism_Homo sapiens_hsa006001.41418419
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40116633
30Circadian rhythm_Homo sapiens_hsa047101.39353301
31Cholinergic synapse_Homo sapiens_hsa047251.38704708
32ABC transporters_Homo sapiens_hsa020101.36629555
33Cocaine addiction_Homo sapiens_hsa050301.35568365
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35202132
35Collecting duct acid secretion_Homo sapiens_hsa049661.31704225
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.27527314
37Oxytocin signaling pathway_Homo sapiens_hsa049211.26512827
38cAMP signaling pathway_Homo sapiens_hsa040241.26198363
39Gastric acid secretion_Homo sapiens_hsa049711.20692270
40Axon guidance_Homo sapiens_hsa043601.19929327
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18833937
42Glucagon signaling pathway_Homo sapiens_hsa049221.17557228
43Pancreatic secretion_Homo sapiens_hsa049721.16286542
44Vibrio cholerae infection_Homo sapiens_hsa051101.11009932
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06761862
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.06055461
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.05696524
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02513770
49Tryptophan metabolism_Homo sapiens_hsa003801.00796700
50ErbB signaling pathway_Homo sapiens_hsa040120.99968481
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96961498
52Fatty acid elongation_Homo sapiens_hsa000620.96468385
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95849351
54Dilated cardiomyopathy_Homo sapiens_hsa054140.93363447
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93272918
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91750361
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90933523
58Phototransduction_Homo sapiens_hsa047440.89731666
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88448209
60mTOR signaling pathway_Homo sapiens_hsa041500.84787619
61Estrogen signaling pathway_Homo sapiens_hsa049150.84770440
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82232554
63Dorso-ventral axis formation_Homo sapiens_hsa043200.81732536
64Glioma_Homo sapiens_hsa052140.81650092
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81398559
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79609762
67Peroxisome_Homo sapiens_hsa041460.79267353
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78575940
69beta-Alanine metabolism_Homo sapiens_hsa004100.78053332
70Sulfur metabolism_Homo sapiens_hsa009200.77818337
71Ras signaling pathway_Homo sapiens_hsa040140.77357042
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75556357
73Wnt signaling pathway_Homo sapiens_hsa043100.74572983
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73704443
75MAPK signaling pathway_Homo sapiens_hsa040100.72300059
76Thyroid hormone synthesis_Homo sapiens_hsa049180.71031123
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69993327
78GnRH signaling pathway_Homo sapiens_hsa049120.68209350
79Caffeine metabolism_Homo sapiens_hsa002320.68117178
80Fatty acid biosynthesis_Homo sapiens_hsa000610.68061625
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67372845
82Gap junction_Homo sapiens_hsa045400.66921438
83Melanoma_Homo sapiens_hsa052180.65957229
84Ether lipid metabolism_Homo sapiens_hsa005650.65430207
85Rheumatoid arthritis_Homo sapiens_hsa053230.64819454
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63815001
87Phagosome_Homo sapiens_hsa041450.63547419
88Melanogenesis_Homo sapiens_hsa049160.61579667
89Choline metabolism in cancer_Homo sapiens_hsa052310.61491878
90Fatty acid degradation_Homo sapiens_hsa000710.61341096
91Insulin resistance_Homo sapiens_hsa049310.60639366
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60498382
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59955606
94Inositol phosphate metabolism_Homo sapiens_hsa005620.59236640
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58914800
96Chemical carcinogenesis_Homo sapiens_hsa052040.57264478
97Ovarian steroidogenesis_Homo sapiens_hsa049130.57172365
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56715982
99Fatty acid metabolism_Homo sapiens_hsa012120.55890545
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53812162
101Mineral absorption_Homo sapiens_hsa049780.52759380
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.51253136
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.50487556
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.48741359
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.48596026
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47188083
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47169049
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46618333
109Rap1 signaling pathway_Homo sapiens_hsa040150.45428922
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45130603
111AMPK signaling pathway_Homo sapiens_hsa041520.44581473
112FoxO signaling pathway_Homo sapiens_hsa040680.44203088
113Basal transcription factors_Homo sapiens_hsa030220.42917124
114T cell receptor signaling pathway_Homo sapiens_hsa046600.42417131
115Oocyte meiosis_Homo sapiens_hsa041140.40484992
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.40144469
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39797494
118Cardiac muscle contraction_Homo sapiens_hsa042600.39789154
119Prostate cancer_Homo sapiens_hsa052150.39592761
120N-Glycan biosynthesis_Homo sapiens_hsa005100.38696686
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37733079
122Renal cell carcinoma_Homo sapiens_hsa052110.37725068
123Platelet activation_Homo sapiens_hsa046110.37699618
124Insulin signaling pathway_Homo sapiens_hsa049100.36940732
125Protein digestion and absorption_Homo sapiens_hsa049740.36849610
126Regulation of autophagy_Homo sapiens_hsa041400.34962386
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33257664
128Endometrial cancer_Homo sapiens_hsa052130.33100249
129Type I diabetes mellitus_Homo sapiens_hsa049400.32938166
130Focal adhesion_Homo sapiens_hsa045100.31970401
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31236636
132Prolactin signaling pathway_Homo sapiens_hsa049170.30684121

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