HCG22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.31953394
2mitochondrion distribution (GO:0048311)6.50384348
3peptide cross-linking (GO:0018149)6.44048778
4negative regulation of activin receptor signaling pathway (GO:0032926)5.83251674
5signal peptide processing (GO:0006465)5.63906767
6keratinocyte differentiation (GO:0030216)5.54584635
7regulation of chemokine-mediated signaling pathway (GO:0070099)5.04793305
8negative regulation of homotypic cell-cell adhesion (GO:0034111)4.81144893
9negative regulation of bone mineralization (GO:0030502)4.61391448
10epidermal cell differentiation (GO:0009913)4.35476027
11negative regulation of keratinocyte proliferation (GO:0010839)4.26674896
12histone-serine phosphorylation (GO:0035404)4.21259372
13citrulline metabolic process (GO:0000052)4.21110002
14tongue development (GO:0043586)4.16486788
15negative regulation of biomineral tissue development (GO:0070168)4.09265503
16regulation of protein localization to cell surface (GO:2000008)4.02785479
17long-chain fatty acid biosynthetic process (GO:0042759)3.95981379
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.93792462
19negative regulation of macroautophagy (GO:0016242)3.82300415
20regulation of autophagic vacuole assembly (GO:2000785)3.76555575
21mitochondrion localization (GO:0051646)3.72590303
22apical protein localization (GO:0045176)3.72040072
23positive regulation of DNA-dependent DNA replication (GO:2000105)3.71174480
24arginine catabolic process (GO:0006527)3.66594558
25positive regulation of catecholamine secretion (GO:0033605)3.58679012
26negative regulation of muscle cell apoptotic process (GO:0010656)3.57538093
27peptidyl-arginine modification (GO:0018195)3.54547628
28negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.46770738
29centrosome localization (GO:0051642)3.36908556
30embryonic digestive tract development (GO:0048566)3.34012716
31regulation of vacuole organization (GO:0044088)3.27156663
32regulation of platelet aggregation (GO:0090330)3.27059645
33forebrain neuron differentiation (GO:0021879)3.25547263
34generation of neurons (GO:0048699)3.25372493
35histone H3-K36 demethylation (GO:0070544)3.23968033
36regulation of keratinocyte proliferation (GO:0010837)3.20858965
37regulation of alkaline phosphatase activity (GO:0010692)3.19814257
38positive regulation of endothelial cell differentiation (GO:0045603)3.19369675
39motile cilium assembly (GO:0044458)3.18886541
40O-glycan processing (GO:0016266)3.16195416
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15871105
42heterochromatin organization (GO:0070828)3.13618106
43regulation of transforming growth factor beta2 production (GO:0032909)3.11797264
44cellular response to lithium ion (GO:0071285)3.07433171
45dopamine biosynthetic process (GO:0042416)3.07011023
46radial glial cell differentiation (GO:0060019)3.04465011
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04127642
48positive regulation of cardiac muscle cell differentiation (GO:2000727)3.02782135
49negative regulation of protein localization to cell surface (GO:2000009)3.01489126
50superoxide anion generation (GO:0042554)2.99717508
51negative regulation of interleukin-17 production (GO:0032700)2.99472194
52positive regulation of receptor internalization (GO:0002092)2.98838427
53cerebral cortex radially oriented cell migration (GO:0021799)2.98303079
54centriole assembly (GO:0098534)2.98296864
55citrulline biosynthetic process (GO:0019240)2.98040336
56outer ear morphogenesis (GO:0042473)2.95616397
57regulation of phosphoprotein phosphatase activity (GO:0043666)2.94468836
58vascular smooth muscle contraction (GO:0014829)2.89159812
59positive regulation of protein homooligomerization (GO:0032464)2.88204877
60lipid particle organization (GO:0034389)2.86604673
61sex differentiation (GO:0007548)2.82763773
62N-terminal protein amino acid acetylation (GO:0006474)2.80660589
63positive regulation of gene expression, epigenetic (GO:0045815)2.78241238
64somatic stem cell division (GO:0048103)2.78067239
65fucose catabolic process (GO:0019317)2.77063651
66L-fucose metabolic process (GO:0042354)2.77063651
67L-fucose catabolic process (GO:0042355)2.77063651
68epidermis development (GO:0008544)2.76250807
69regulation of activin receptor signaling pathway (GO:0032925)2.75757211
70cellular response to zinc ion (GO:0071294)2.73436371
71positive regulation of DNA-templated transcription, initiation (GO:2000144)2.73200666
72regulation of glycogen (starch) synthase activity (GO:2000465)2.72700323
73response to muscle activity (GO:0014850)2.72237287
74rRNA methylation (GO:0031167)2.71334847
75positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.70758523
76regulation of oxidative stress-induced neuron death (GO:1903203)2.70180343
77positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.69365266
78asymmetric protein localization (GO:0008105)2.68470656
79mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66163887
80gene silencing by RNA (GO:0031047)2.65749434
81coenzyme catabolic process (GO:0009109)2.65565158
82centriole replication (GO:0007099)2.63739712
83negative regulation of platelet activation (GO:0010544)2.61140366
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60935792
85mitochondrion transport along microtubule (GO:0047497)2.60935792
86negative regulation of striated muscle cell apoptotic process (GO:0010664)2.60871007
87response to pheromone (GO:0019236)2.59083912
88presynaptic membrane organization (GO:0097090)2.57848829
89negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.55145145
90lymph vessel development (GO:0001945)2.55111571
91mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.54937135
92positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.54937135
93negative regulation of systemic arterial blood pressure (GO:0003085)2.54505288
94detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.54066860
95negative regulation of cell-cell adhesion (GO:0022408)2.53737064
96regulation of cell maturation (GO:1903429)2.52034953
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.51677986
98regulation of translation, ncRNA-mediated (GO:0045974)2.51677986
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51677986
100regulation of DNA-templated transcription, initiation (GO:2000142)2.51073197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.39355235
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.19155679
3ZNF274_21170338_ChIP-Seq_K562_Hela3.59537779
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41282591
5VDR_22108803_ChIP-Seq_LS180_Human2.93864767
6AR_21572438_ChIP-Seq_LNCaP_Human2.68846290
7EZH2_22144423_ChIP-Seq_EOC_Human2.55514756
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52955541
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.47933138
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42848596
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29503999
12GBX2_23144817_ChIP-Seq_PC3_Human2.21917318
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00113974
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96263973
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.96263973
16RXR_22108803_ChIP-Seq_LS180_Human1.95303989
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91062302
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84396898
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83781221
20P300_19829295_ChIP-Seq_ESCs_Human1.82365202
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78477136
22IGF1R_20145208_ChIP-Seq_DFB_Human1.76981799
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76451611
24BCAT_22108803_ChIP-Seq_LS180_Human1.76398656
25AHR_22903824_ChIP-Seq_MCF-7_Human1.75472412
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73149278
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71091416
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.69500896
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.62917750
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55636795
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55331194
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.50521196
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49369074
34GATA1_22025678_ChIP-Seq_K562_Human1.47996428
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.47433114
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44297996
37AR_25329375_ChIP-Seq_VCAP_Human1.44150721
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.37432608
39ER_23166858_ChIP-Seq_MCF-7_Human1.36514196
40SMAD4_21799915_ChIP-Seq_A2780_Human1.35778399
41EWS_26573619_Chip-Seq_HEK293_Human1.33903659
42FUS_26573619_Chip-Seq_HEK293_Human1.31997441
43STAT3_23295773_ChIP-Seq_U87_Human1.31135206
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30789619
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29279391
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28881709
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27553934
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.26828878
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26292295
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26251444
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25644369
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24313648
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22600761
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22296618
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21280418
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20048015
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18363810
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16397313
59TBL1_22424771_ChIP-Seq_293T_Human1.16288379
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.15799697
61TP53_18474530_ChIP-ChIP_U2OS_Human1.14510564
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11843921
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10407327
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.10335846
65CDX2_22108803_ChIP-Seq_LS180_Human1.09413464
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09302641
67VDR_24787735_ChIP-Seq_THP-1_Human1.09235724
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08447077
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08097572
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07430378
71TCF4_23295773_ChIP-Seq_U87_Human1.06249697
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.04775082
73TAF15_26573619_Chip-Seq_HEK293_Human1.04181764
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.01463822
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00360925
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00357243
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99601180
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98842546
79* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98396821
80* CJUN_26792858_Chip-Seq_BT549_Human0.98065398
81SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97223082
82ISL1_27105846_Chip-Seq_CPCs_Mouse0.96669527
83OCT1_27270436_Chip-Seq_PROSTATE_Human0.96330535
84ESR1_21235772_ChIP-Seq_MCF-7_Human0.96089531
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93853330
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93574986
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91386645
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.91378201
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91152358
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90121666
91* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89867687
92RUNX_20019798_ChIP-Seq_JUKART_Human0.89681968
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89660530
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89493870
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89493870
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.88829612
97CBP_21632823_ChIP-Seq_H3396_Human0.88367495
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.88128415
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.87637645
100SOX9_26525672_Chip-Seq_HEART_Mouse0.86975346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.85302559
2MP0008057_abnormal_DNA_replication5.73087246
3MP0010368_abnormal_lymphatic_system4.25463772
4MP0002876_abnormal_thyroid_physiology2.88051495
5MP0009053_abnormal_anal_canal2.44171770
6MP0003136_yellow_coat_color2.38233144
7MP0003315_abnormal_perineum_morphology2.33785293
8MP0001879_abnormal_lymphatic_vessel2.17206149
9MP0005499_abnormal_olfactory_system2.15855047
10MP0005394_taste/olfaction_phenotype2.15855047
11MP0004885_abnormal_endolymph2.12305476
12MP0000049_abnormal_middle_ear2.10388736
13MP0000537_abnormal_urethra_morphology2.07320534
14MP0005647_abnormal_sex_gland2.06108814
15MP0004043_abnormal_pH_regulation2.04912876
16MP0005187_abnormal_penis_morphology1.91507520
17MP0001346_abnormal_lacrimal_gland1.89967192
18MP0005248_abnormal_Harderian_gland1.87860526
19MP0002796_impaired_skin_barrier1.82347309
20MP0002736_abnormal_nociception_after1.79854301
21MP0002249_abnormal_larynx_morphology1.78889172
22MP0002138_abnormal_hepatobiliary_system1.70141009
23MP0008789_abnormal_olfactory_epithelium1.63650711
24MP0005501_abnormal_skin_physiology1.57931426
25MP0009250_abnormal_appendicular_skeleto1.53903618
26MP0001984_abnormal_olfaction1.52394638
27MP0005409_darkened_coat_color1.51478883
28MP0003693_abnormal_embryo_hatching1.49520680
29MP0001968_abnormal_touch/_nociception1.40561695
30MP0003755_abnormal_palate_morphology1.40147656
31MP0005367_renal/urinary_system_phenotyp1.39148633
32MP0000516_abnormal_urinary_system1.39148633
33MP0002233_abnormal_nose_morphology1.37279648
34MP0003868_abnormal_feces_composition1.33921279
35MP0008004_abnormal_stomach_pH1.33365691
36MP0010678_abnormal_skin_adnexa1.32392893
37MP0000566_synostosis1.30439316
38MP0002163_abnormal_gland_morphology1.24691933
39MP0003938_abnormal_ear_development1.24577199
40MP0000613_abnormal_salivary_gland1.24213700
41MP0005266_abnormal_metabolism1.21496002
42MP0000678_abnormal_parathyroid_gland1.20741973
43MP0001502_abnormal_circadian_rhythm1.16603370
44MP0002098_abnormal_vibrissa_morphology1.16463633
45MP0000465_gastrointestinal_hemorrhage1.15987041
46MP0000026_abnormal_inner_ear1.15550926
47MP0001485_abnormal_pinna_reflex1.15163885
48MP0010030_abnormal_orbit_morphology1.13702544
49MP0004264_abnormal_extraembryonic_tissu1.12636195
50MP0003935_abnormal_craniofacial_develop1.11382593
51MP0009046_muscle_twitch1.09499213
52MP0005275_abnormal_skin_tensile1.08993925
53MP0000749_muscle_degeneration1.07938317
54MP0006276_abnormal_autonomic_nervous1.06675091
55MP0005166_decreased_susceptibility_to1.04542204
56MP0003077_abnormal_cell_cycle0.99522950
57MP0001905_abnormal_dopamine_level0.99041130
58MP0000631_abnormal_neuroendocrine_gland0.98805446
59MP0001544_abnormal_cardiovascular_syste0.94811914
60MP0005385_cardiovascular_system_phenoty0.94811914
61MP0000534_abnormal_ureter_morphology0.94376634
62MP0004484_altered_response_of0.94285437
63MP0003705_abnormal_hypodermis_morpholog0.93071101
64MP0001486_abnormal_startle_reflex0.89256117
65MP0003880_abnormal_central_pattern0.89245077
66MP0001501_abnormal_sleep_pattern0.87104294
67MP0000762_abnormal_tongue_morphology0.85398639
68MP0002837_dystrophic_cardiac_calcinosis0.83688208
69MP0002108_abnormal_muscle_morphology0.83236626
70MP0002733_abnormal_thermal_nociception0.82684100
71MP0002095_abnormal_skin_pigmentation0.81336936
72MP0004215_abnormal_myocardial_fiber0.79710612
73MP0000920_abnormal_myelination0.79002176
74MP0001849_ear_inflammation0.78857883
75MP0000778_abnormal_nervous_system0.78714743
76MP0005503_abnormal_tendon_morphology0.77481561
77MP0003806_abnormal_nucleotide_metabolis0.77313132
78MP0005595_abnormal_vascular_smooth0.76417421
79MP0005646_abnormal_pituitary_gland0.76406328
80MP0001270_distended_abdomen0.75068582
81MP0005253_abnormal_eye_physiology0.74739529
82MP0004381_abnormal_hair_follicle0.74415685
83MP0002272_abnormal_nervous_system0.72890395
84MP0003879_abnormal_hair_cell0.72746874
85MP0006072_abnormal_retinal_apoptosis0.72233871
86MP0005310_abnormal_salivary_gland0.69388773
87MP0002102_abnormal_ear_morphology0.67898068
88MP0002127_abnormal_cardiovascular_syste0.67003198
89MP0006138_congestive_heart_failure0.66551005
90MP0000681_abnormal_thyroid_gland0.65793068
91MP0009115_abnormal_fat_cell0.64660869
92MP0002751_abnormal_autonomic_nervous0.64181188
93MP0002177_abnormal_outer_ear0.64154674
94MP0010094_abnormal_chromosome_stability0.62421568
95MP0000685_abnormal_immune_system0.61562329
96MP0001529_abnormal_vocalization0.61397418
97MP0004883_abnormal_blood_vessel0.61393321
98MP0000569_abnormal_digit_pigmentation0.61213917
99MP0002234_abnormal_pharynx_morphology0.59469653
100MP0001963_abnormal_hearing_physiology0.59170083

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)7.57556643
2Degeneration of anterior horn cells (HP:0002398)7.19407529
3Abnormality of the anterior horn cell (HP:0006802)7.19407529
4Amyotrophic lateral sclerosis (HP:0007354)6.67178615
5Upper motor neuron abnormality (HP:0002127)6.55792080
6Conjunctival telangiectasia (HP:0000524)4.99126357
7Pustule (HP:0200039)4.95482734
8Abnormality of the columella (HP:0009929)4.45174402
9Impaired proprioception (HP:0010831)4.22659872
10Abnormality of the vasculature of the conjunctiva (HP:0008054)4.06698613
11Atonic seizures (HP:0010819)4.00744584
12Gaze-evoked nystagmus (HP:0000640)3.97464992
13Increased IgE level (HP:0003212)3.85477600
14Split foot (HP:0001839)3.60558402
15Atrophy/Degeneration involving motor neurons (HP:0007373)3.23231505
16Parakeratosis (HP:0001036)3.18458756
17Hypergammaglobulinemia (HP:0010702)3.15953763
18Erythroderma (HP:0001019)2.94596578
19Absence seizures (HP:0002121)2.90862978
20Difficulty walking (HP:0002355)2.81914984
21Hyperactive renin-angiotensin system (HP:0000841)2.81690494
22Hyperkalemia (HP:0002153)2.80395654
23Decreased circulating renin level (HP:0003351)2.70671387
24Eosinophilia (HP:0001880)2.61084251
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.58797262
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.53237295
27Sparse scalp hair (HP:0002209)2.47910969
28Cystic hygroma (HP:0000476)2.46764052
29High anterior hairline (HP:0009890)2.44710108
30Abnormality of the incisor (HP:0000676)2.41639036
31Oligodontia (HP:0000677)2.36970371
32Hyperventilation (HP:0002883)2.33297124
33Abnormality of small intestinal villus morphology (HP:0011472)2.33163978
34Villous atrophy (HP:0011473)2.33163978
35Chronic bronchitis (HP:0004469)2.33139061
36Nasal polyposis (HP:0100582)2.32815565
37Oral leukoplakia (HP:0002745)2.28109985
38Clonus (HP:0002169)2.25622606
39Protruding tongue (HP:0010808)2.23745943
40Reduced antithrombin III activity (HP:0001976)2.20474375
41Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.20249158
42Oligodactyly (hands) (HP:0001180)2.19514692
43Abnormality of macular pigmentation (HP:0008002)2.18487473
44Abnormality of ocular smooth pursuit (HP:0000617)2.14826892
45Furrowed tongue (HP:0000221)2.13355106
46Absent speech (HP:0001344)2.12321702
47Clumsiness (HP:0002312)2.11069102
48Abnormality of the nasal mucosa (HP:0000433)2.08713253
49Hypokalemic alkalosis (HP:0001949)2.08124741
50Abnormality of the frontal sinuses (HP:0002687)2.04877137
51Decreased motor nerve conduction velocity (HP:0003431)2.03350901
52Dialeptic seizures (HP:0011146)2.02827557
53Mucosal telangiectasiae (HP:0100579)1.98683352
54Partial duplication of the phalanx of hand (HP:0009999)1.95478123
55True hermaphroditism (HP:0010459)1.95400480
56Abnormality of the pubic bones (HP:0003172)1.92083454
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91877084
58Intellectual disability, progressive (HP:0006887)1.89433997
59Inability to walk (HP:0002540)1.88519310
60Granulocytopenia (HP:0001913)1.86340121
61Lip pit (HP:0100267)1.84258110
62Urethral obstruction (HP:0000796)1.83721392
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.83136034
64Curly hair (HP:0002212)1.82747377
65Broad-based gait (HP:0002136)1.82733661
66Long clavicles (HP:0000890)1.82129023
67Hypothermia (HP:0002045)1.79752493
68Stenosis of the external auditory canal (HP:0000402)1.77343714
69Oligodactyly (HP:0012165)1.76964615
70Median cleft lip (HP:0000161)1.76705583
71Partial duplication of thumb phalanx (HP:0009944)1.75383715
72Generalized tonic-clonic seizures (HP:0002069)1.74553764
73Abnormality of the antihelix (HP:0009738)1.73374411
74Aplasia cutis congenita (HP:0001057)1.71313852
75B lymphocytopenia (HP:0010976)1.70650618
76Thickened helices (HP:0000391)1.69631573
77Intestinal atresia (HP:0011100)1.69375426
78Arterial tortuosity (HP:0005116)1.69202008
79Panhypogammaglobulinemia (HP:0003139)1.69200295
80Impaired vibratory sensation (HP:0002495)1.67861020
81Renal dysplasia (HP:0000110)1.66762942
82Impaired social interactions (HP:0000735)1.66391324
83Abnormal social behavior (HP:0012433)1.66391324
84Limb ataxia (HP:0002070)1.66289956
85Abnormality of eosinophils (HP:0001879)1.64283182
86Limb dystonia (HP:0002451)1.64262229
87Hypoplastic ischia (HP:0003175)1.63851345
88Poor eye contact (HP:0000817)1.63635362
892-3 toe syndactyly (HP:0004691)1.63220169
90Hyporeflexia of lower limbs (HP:0002600)1.61307068
91Abnormality of renin-angiotensin system (HP:0000847)1.60827664
92Gastroesophageal reflux (HP:0002020)1.59556469
93Acute lymphatic leukemia (HP:0006721)1.57596092
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.57361718
95Hypoplastic iliac wings (HP:0002866)1.55976830
96Abnormal hair whorl (HP:0010721)1.55561487
97Tented upper lip vermilion (HP:0010804)1.55343256
98Radioulnar synostosis (HP:0002974)1.54176433
99Low posterior hairline (HP:0002162)1.54055111
100Abnormality of the shoulder girdle musculature (HP:0001435)1.52340026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.50547082
2TNIK3.56966825
3MARK33.00149099
4NEK92.72770255
5SGK22.67335269
6CASK2.65437784
7MAP3K92.61666822
8BCR2.56463882
9CDK62.46644269
10SGK4942.36577713
11SGK2232.36577713
12EPHB22.11104253
13STK38L2.05093954
14PNCK1.98817386
15OBSCN1.88471965
16CSNK1A1L1.85762376
17SGK31.84819801
18CDK31.72149606
19CSNK1G31.70800971
20MAP2K71.69572776
21LATS11.67309399
22NEK21.54817704
23CDK41.43431187
24WNK31.41159359
25CSNK1G21.39804294
26CSNK1G11.35086336
27ZAK1.33975877
28NLK1.33964344
29WEE11.29009066
30MAP3K101.27875490
31PAK31.18040899
32FGFR21.15148628
33NME11.09911667
34FRK1.09228611
35PKN11.08871764
36MAPK151.05843098
37CAMK1D0.98966991
38MARK10.95581485
39MAPK130.94971250
40CAMK1G0.94866003
41PRKCQ0.94242599
42MAP4K20.92251171
43MINK10.91731720
44TYRO30.90191880
45IRAK20.89257846
46PRKD20.81520686
47PLK20.80789125
48MAP3K10.78980807
49LATS20.78019842
50TAF10.72769427
51STK240.72492730
52VRK10.72186171
53TAOK10.70812073
54RPS6KB10.68952142
55DYRK30.66796909
56RAF10.66019539
57TLK10.65474293
58NTRK20.60514009
59CCNB10.57676214
60PAK10.55904203
61TSSK60.55603744
62BMPR1B0.55599833
63RPS6KA50.55100767
64CAMK40.54188457
65RPS6KA40.53913174
66ATM0.53454061
67NUAK10.52556011
68STK390.51538106
69MAP3K70.51043246
70CSNK1A10.48749413
71PDGFRB0.46557761
72SGK10.46221216
73DMPK0.46085770
74PRKCI0.45235038
75EIF2AK30.44162796
76MAPKAPK50.42941058
77DYRK20.40689250
78PRKG10.39944788
79KSR20.37552472
80ROCK10.37170140
81AURKA0.34909255
82MAP3K50.33987024
83PRKAA10.33342742
84STK40.32852672
85INSRR0.32844607
86CDK50.31272037
87WNK40.29982574
88TIE10.25797285
89YES10.25503558
90AKT10.25427686
91RPS6KA10.24774083
92SYK0.24721346
93WNK10.23826226
94HIPK20.22179175
95MELK0.21826547
96STK30.20284530
97EGFR0.19127880
98PLK40.18966675
99AKT20.18593446
100IKBKE0.18555153

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.01892024
2Salivary secretion_Homo sapiens_hsa049703.00431581
3Phototransduction_Homo sapiens_hsa047442.85881477
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.47357443
5Circadian rhythm_Homo sapiens_hsa047102.38020838
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30637798
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.96736385
8Systemic lupus erythematosus_Homo sapiens_hsa053221.89911323
9Alcoholism_Homo sapiens_hsa050341.89532192
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84644051
11Basal transcription factors_Homo sapiens_hsa030221.84325215
12Hedgehog signaling pathway_Homo sapiens_hsa043401.67959902
13Cocaine addiction_Homo sapiens_hsa050301.66664820
14Renin secretion_Homo sapiens_hsa049241.63041974
15Amphetamine addiction_Homo sapiens_hsa050311.62286825
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.57908826
17Oxytocin signaling pathway_Homo sapiens_hsa049211.50769561
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.41616410
19Gastric acid secretion_Homo sapiens_hsa049711.37207571
20Circadian entrainment_Homo sapiens_hsa047131.33297902
21TGF-beta signaling pathway_Homo sapiens_hsa043501.32309180
22Melanogenesis_Homo sapiens_hsa049161.30994875
23Protein export_Homo sapiens_hsa030601.27785396
24Endometrial cancer_Homo sapiens_hsa052131.23078527
25Nitrogen metabolism_Homo sapiens_hsa009101.22456040
26Estrogen signaling pathway_Homo sapiens_hsa049151.20547289
27Oocyte meiosis_Homo sapiens_hsa041141.20259566
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17797145
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15377492
30Taste transduction_Homo sapiens_hsa047421.12144841
31Gap junction_Homo sapiens_hsa045401.06507552
32Calcium signaling pathway_Homo sapiens_hsa040201.03610359
33Dopaminergic synapse_Homo sapiens_hsa047281.03497354
34Long-term potentiation_Homo sapiens_hsa047201.01665499
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01413882
36Basal cell carcinoma_Homo sapiens_hsa052171.00832289
37B cell receptor signaling pathway_Homo sapiens_hsa046620.98244811
38Hippo signaling pathway_Homo sapiens_hsa043900.96110954
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95854766
40Chemical carcinogenesis_Homo sapiens_hsa052040.93558173
41Hepatitis B_Homo sapiens_hsa051610.93393442
42FoxO signaling pathway_Homo sapiens_hsa040680.93297911
43Allograft rejection_Homo sapiens_hsa053300.92140759
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91951183
45Wnt signaling pathway_Homo sapiens_hsa043100.90662405
46Primary immunodeficiency_Homo sapiens_hsa053400.89847833
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89252630
48Axon guidance_Homo sapiens_hsa043600.88180928
49Glucagon signaling pathway_Homo sapiens_hsa049220.87240332
50MAPK signaling pathway_Homo sapiens_hsa040100.86334625
51cAMP signaling pathway_Homo sapiens_hsa040240.85881161
52Glioma_Homo sapiens_hsa052140.85281882
53Prostate cancer_Homo sapiens_hsa052150.84124002
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.83402484
55Dilated cardiomyopathy_Homo sapiens_hsa054140.82055609
56Autoimmune thyroid disease_Homo sapiens_hsa053200.80924685
57Arachidonic acid metabolism_Homo sapiens_hsa005900.80406821
58Graft-versus-host disease_Homo sapiens_hsa053320.76062346
59Serotonergic synapse_Homo sapiens_hsa047260.75112390
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74724520
61beta-Alanine metabolism_Homo sapiens_hsa004100.73918490
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71276031
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69944487
64T cell receptor signaling pathway_Homo sapiens_hsa046600.69703087
65GnRH signaling pathway_Homo sapiens_hsa049120.66190246
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.65831576
67Colorectal cancer_Homo sapiens_hsa052100.65126964
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63373438
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.62493646
70PPAR signaling pathway_Homo sapiens_hsa033200.61894195
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58988622
72Tuberculosis_Homo sapiens_hsa051520.58626229
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.56554489
74Cholinergic synapse_Homo sapiens_hsa047250.56352166
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55608075
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55491033
77Glutamatergic synapse_Homo sapiens_hsa047240.54823397
78Propanoate metabolism_Homo sapiens_hsa006400.54741829
79Asthma_Homo sapiens_hsa053100.54411831
80Nicotine addiction_Homo sapiens_hsa050330.54384967
81Influenza A_Homo sapiens_hsa051640.53397895
82Ras signaling pathway_Homo sapiens_hsa040140.53304636
83Pertussis_Homo sapiens_hsa051330.53125963
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52122842
85Butanoate metabolism_Homo sapiens_hsa006500.52079837
86Dorso-ventral axis formation_Homo sapiens_hsa043200.51241975
87Insulin signaling pathway_Homo sapiens_hsa049100.50652799
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50568270
89Type I diabetes mellitus_Homo sapiens_hsa049400.50467151
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48485110
91Rap1 signaling pathway_Homo sapiens_hsa040150.48157588
92Prolactin signaling pathway_Homo sapiens_hsa049170.47492745
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46290191
94Type II diabetes mellitus_Homo sapiens_hsa049300.41841442
95Adherens junction_Homo sapiens_hsa045200.41677417
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41499431
97Herpes simplex infection_Homo sapiens_hsa051680.41430868
98Fanconi anemia pathway_Homo sapiens_hsa034600.40463705
99Cell cycle_Homo sapiens_hsa041100.40387021
100AMPK signaling pathway_Homo sapiens_hsa041520.37573929

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