HCG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)6.93433995
2basement membrane organization (GO:0071711)6.77709829
3regulation of cardioblast differentiation (GO:0051890)6.54420328
4skin morphogenesis (GO:0043589)6.15892838
5intestinal epithelial cell development (GO:0060576)6.15438668
6fusion of sperm to egg plasma membrane (GO:0007342)6.06392401
7melanin biosynthetic process (GO:0042438)5.40550294
8regulation of secondary heart field cardioblast proliferation (GO:0003266)5.28153067
9regulation of cardioblast proliferation (GO:0003264)5.28153067
10keratinization (GO:0031424)5.15676328
11secondary metabolite biosynthetic process (GO:0044550)5.04132631
12acrosome reaction (GO:0007340)4.96542246
13deoxyribose phosphate biosynthetic process (GO:0046385)4.86005377
142-deoxyribonucleotide biosynthetic process (GO:0009265)4.86005377
15cell migration involved in heart development (GO:0060973)4.74492405
16negative regulation of chemokine production (GO:0032682)4.74462696
17melanin metabolic process (GO:0006582)4.73987451
18regulation of water loss via skin (GO:0033561)4.73979067
19atrioventricular valve morphogenesis (GO:0003181)4.54442458
20deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.37663376
21collagen fibril organization (GO:0030199)4.36987924
22sperm motility (GO:0030317)4.32720352
23plasma membrane fusion (GO:0045026)4.31183848
24hemidesmosome assembly (GO:0031581)4.18072260
25negative regulation of interleukin-17 production (GO:0032700)4.10762730
26ketone body metabolic process (GO:1902224)3.98647930
27deoxyribonucleotide biosynthetic process (GO:0009263)3.90126513
28regulation of response to tumor cell (GO:0002834)3.89367622
29positive regulation of response to tumor cell (GO:0002836)3.89367622
30positive regulation of immune response to tumor cell (GO:0002839)3.89367622
31regulation of immune response to tumor cell (GO:0002837)3.89367622
32establishment of skin barrier (GO:0061436)3.86288788
33response to pheromone (GO:0019236)3.79826607
34pericardium development (GO:0060039)3.69629007
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.69220608
36desmosome organization (GO:0002934)3.68463771
37negative regulation of chondrocyte differentiation (GO:0032331)3.52736293
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.49946551
39chondrocyte development (GO:0002063)3.45799183
40collagen catabolic process (GO:0030574)3.44879356
41nucleoside diphosphate biosynthetic process (GO:0009133)3.40594549
42endocardial cushion development (GO:0003197)3.35889495
43cellular ketone body metabolic process (GO:0046950)3.35611995
44cellular response to type I interferon (GO:0071357)3.33396224
45type I interferon signaling pathway (GO:0060337)3.33396224
46multicellular organism reproduction (GO:0032504)3.32930489
47response to interferon-beta (GO:0035456)3.27757305
48positive regulation of response to biotic stimulus (GO:0002833)3.26785080
49response to type I interferon (GO:0034340)3.21473341
50negative regulation of cartilage development (GO:0061037)3.20708295
51peptidyl-proline hydroxylation (GO:0019511)3.20192264
52negative regulation of biomineral tissue development (GO:0070168)3.20173824
53sperm-egg recognition (GO:0035036)3.19068236
54multicellular organismal catabolic process (GO:0044243)3.19050189
55collagen metabolic process (GO:0032963)3.16184772
56binding of sperm to zona pellucida (GO:0007339)3.12312974
57spermatid development (GO:0007286)3.11482232
58negative regulation of cardiac muscle tissue growth (GO:0055022)3.08550129
59negative regulation of heart growth (GO:0061117)3.08550129
60chromosome condensation (GO:0030261)3.08129882
61multicellular organismal macromolecule metabolic process (GO:0044259)3.08106239
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06444623
63bone resorption (GO:0045453)3.01981637
64reproduction (GO:0000003)3.00917987
65establishment of tissue polarity (GO:0007164)2.99181399
66establishment of planar polarity (GO:0001736)2.99181399
674-hydroxyproline metabolic process (GO:0019471)2.98423254
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94646963
69multicellular organismal metabolic process (GO:0044236)2.92335233
70multicellular organismal water homeostasis (GO:0050891)2.90677905
71regulation of RIG-I signaling pathway (GO:0039535)2.89900889
72regulation of odontogenesis (GO:0042481)2.88324914
73negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.86428011
74protein retention in ER lumen (GO:0006621)2.81849538
75positive regulation of prostaglandin secretion (GO:0032308)2.80561846
76response to thyroid hormone (GO:0097066)2.79073153
77negative regulation of gluconeogenesis (GO:0045721)2.76359627
78DNA packaging (GO:0006323)2.75942989
79response to UV-B (GO:0010224)2.73642510
80positive regulation of epidermal cell differentiation (GO:0045606)2.72849806
81negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.71569300
82keratan sulfate metabolic process (GO:0042339)2.71408698
83sexual reproduction (GO:0019953)2.69307437
84nonribosomal peptide biosynthetic process (GO:0019184)2.67764556
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67641222
86regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.67428776
87protein hydroxylation (GO:0018126)2.67002398
88cellular response to exogenous dsRNA (GO:0071360)2.65683727
89bone mineralization (GO:0030282)2.65591554
90spermatid nucleus differentiation (GO:0007289)2.64255009
91negative regulation of cardiac muscle tissue development (GO:0055026)2.63350755
92mitotic G1 DNA damage checkpoint (GO:0031571)2.62075770
93regulation of T cell mediated cytotoxicity (GO:0001914)2.60528607
94polyketide metabolic process (GO:0030638)2.60386552
95doxorubicin metabolic process (GO:0044598)2.60386552
96daunorubicin metabolic process (GO:0044597)2.60386552
97negative regulation of inclusion body assembly (GO:0090084)2.60056065
98microtubule depolymerization (GO:0007019)2.59589714
99regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58016047
100glomerular basement membrane development (GO:0032836)2.57850955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.83501062
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.63930483
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.09709466
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.06346188
5ZNF263_19887448_ChIP-Seq_K562_Human3.44829539
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21613734
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.94207053
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.77168500
9P63_26484246_Chip-Seq_KERATINOCYTES_Human2.58865107
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.51165818
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33185004
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24543334
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15986537
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.13978461
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.13978461
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.13309944
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85085791
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83899498
19ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.82703096
20JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78148075
21RACK7_27058665_Chip-Seq_MCF-7_Human1.77656386
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.75105508
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.72090014
24* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67899284
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66303394
26CJUN_26792858_Chip-Seq_BT549_Human1.62209008
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57592997
28TP63_22573176_ChIP-Seq_HFKS_Human1.55970729
29ATF3_27146783_Chip-Seq_COLON_Human1.55387548
30LXR_22292898_ChIP-Seq_THP-1_Human1.54712639
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49578685
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45948577
33BCL6_27268052_Chip-Seq_Bcells_Human1.45253144
34P68_20966046_ChIP-Seq_HELA_Human1.38893848
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.36883487
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.33671663
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33495903
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32738050
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32099008
40RBPJ_21746931_ChIP-Seq_IB4_Human1.29603618
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27455505
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.27192050
43SMC4_20622854_ChIP-Seq_HELA_Human1.27186849
44* CTCF_20526341_ChIP-Seq_ESCs_Human1.26894617
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25611930
46UBF1/2_26484160_Chip-Seq_HMECs_Human1.24771775
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24416362
48E2F1_20622854_ChIP-Seq_HELA_Human1.23859951
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22741841
50KLF5_25053715_ChIP-Seq_YYC3_Human1.21352672
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19589549
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.19424484
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17911424
54TP53_22127205_ChIP-Seq_IMR90_Human1.16450844
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15788247
56* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12270714
57TP63_23658742_ChIP-Seq_EP156T_Human1.10777624
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10750565
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10545221
60CTCF_27219007_Chip-Seq_Bcells_Human1.10262749
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10246682
62CSB_26484114_Chip-Seq_FIBROBLAST_Human1.09993510
63BCOR_27268052_Chip-Seq_Bcells_Human1.08312668
64* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07679733
65SA1_27219007_Chip-Seq_Bcells_Human1.07181910
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06947697
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06780995
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.06531350
69SOX2_20726797_ChIP-Seq_SW620_Human1.06380773
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05901782
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.05467042
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04835022
73GATA6_25053715_ChIP-Seq_YYC3_Human1.04049905
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03922346
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.01767981
76P300_27268052_Chip-Seq_Bcells_Human0.99475313
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.99263723
78* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98035748
79TFEB_21752829_ChIP-Seq_HELA_Human0.97616100
80P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95692006
81TET1_21451524_ChIP-Seq_MESCs_Mouse0.95372708
82TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95072206
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91562450
84CTCF_21964334_Chip-Seq_Bcells_Human0.89360958
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89184700
86P53_21459846_ChIP-Seq_SAOS-2_Human0.89006077
87RAC3_21632823_ChIP-Seq_H3396_Human0.88800951
88STAT1_20625510_ChIP-Seq_HELA_Human0.88720663
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87893562
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87144113
91ESR1_20079471_ChIP-ChIP_T-47D_Human0.87060226
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86483805
93ETS1_21867929_ChIP-Seq_TH2_Mouse0.85363983
94GATA4_25053715_ChIP-Seq_YYC3_Human0.84984513
95* MITF_21258399_ChIP-Seq_MELANOMA_Human0.83764679
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.83504484
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82841953
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82760145
99TAF2_19829295_ChIP-Seq_ESCs_Human0.82717556
100GATA1_22025678_ChIP-Seq_K562_Human0.82564916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.52760539
2MP0005503_abnormal_tendon_morphology5.81769098
3MP0005275_abnormal_skin_tensile5.09244888
4MP0005257_abnormal_intraocular_pressure4.59429760
5MP0003806_abnormal_nucleotide_metabolis4.18572134
6MP0005410_abnormal_fertilization3.57556528
7MP0000372_irregular_coat_pigmentation3.03767205
8MP0001348_abnormal_lacrimal_gland2.76170624
9MP0010234_abnormal_vibrissa_follicle2.59936576
10MP0008438_abnormal_cutaneous_collagen2.58777845
11MP0004381_abnormal_hair_follicle2.49860402
12MP0002796_impaired_skin_barrier2.21181183
13MP0005171_absent_coat_pigmentation2.19509139
14MP0002254_reproductive_system_inflammat2.17002958
15MP0000462_abnormal_digestive_system2.15156639
16MP0005508_abnormal_skeleton_morphology2.14349222
17MP0008260_abnormal_autophagy2.12096505
18MP0002060_abnormal_skin_morphology2.09751193
19MP0005408_hypopigmentation2.05956904
20MP0005377_hearing/vestibular/ear_phenot2.00070432
21MP0003878_abnormal_ear_physiology2.00070432
22MP0009697_abnormal_copulation1.93985830
23MP0000579_abnormal_nail_morphology1.93700969
24MP0003950_abnormal_plasma_membrane1.72211512
25MP0005075_abnormal_melanosome_morpholog1.71947452
26MP0005023_abnormal_wound_healing1.70497237
27MP0000762_abnormal_tongue_morphology1.67933398
28MP0005646_abnormal_pituitary_gland1.65998349
29MP0002108_abnormal_muscle_morphology1.51051177
30MP0002877_abnormal_melanocyte_morpholog1.49481731
31MP0001542_abnormal_bone_strength1.49461231
32MP0000678_abnormal_parathyroid_gland1.47092495
33MP0004134_abnormal_chest_morphology1.44544665
34MP0005501_abnormal_skin_physiology1.44141898
35MP0001849_ear_inflammation1.40912872
36MP0009250_abnormal_appendicular_skeleto1.38587183
37MP0000467_abnormal_esophagus_morphology1.37128777
38MP0010678_abnormal_skin_adnexa1.32965534
39MP0000015_abnormal_ear_pigmentation1.30529777
40MP0010771_integument_phenotype1.26071671
41MP0000681_abnormal_thyroid_gland1.24794791
42MP0003011_delayed_dark_adaptation1.22592836
43MP0000371_diluted_coat_color1.19664961
44MP0001216_abnormal_epidermal_layer1.18053767
45MP0001243_abnormal_dermal_layer1.18023530
46MP0005390_skeleton_phenotype1.14790090
47MP0002282_abnormal_trachea_morphology1.09275767
48MP0005164_abnormal_response_to1.07861439
49MP0003786_premature_aging1.04752046
50MP0003186_abnormal_redox_activity1.01385197
51MP0000858_altered_metastatic_potential1.00807830
52MP0006054_spinal_hemorrhage1.00557240
53MP0000377_abnormal_hair_follicle0.99060784
54MP0009780_abnormal_chondrocyte_physiolo0.98356096
55MP0003698_abnormal_male_reproductive0.97622526
56MP0003136_yellow_coat_color0.97594375
57MP0000383_abnormal_hair_follicle0.92787031
58MP0001191_abnormal_skin_condition0.92184794
59MP0003453_abnormal_keratinocyte_physiol0.91928726
60MP0002075_abnormal_coat/hair_pigmentati0.90570683
61MP0004883_abnormal_blood_vessel0.90399175
62MP0005647_abnormal_sex_gland0.90204560
63MP0002896_abnormal_bone_mineralization0.88138409
64MP0004264_abnormal_extraembryonic_tissu0.86993212
65MP0003941_abnormal_skin_development0.83875357
66MP0004947_skin_inflammation0.83675271
67MP0002098_abnormal_vibrissa_morphology0.83594387
68MP0003191_abnormal_cellular_cholesterol0.79399335
69MP0003718_maternal_effect0.75300400
70MP0004782_abnormal_surfactant_physiolog0.75105816
71MP0000003_abnormal_adipose_tissue0.75045816
72MP0002295_abnormal_pulmonary_circulatio0.74163300
73MP0003448_altered_tumor_morphology0.72450917
74MP0002095_abnormal_skin_pigmentation0.70681463
75MP0000627_abnormal_mammary_gland0.70240027
76MP0000013_abnormal_adipose_tissue0.70156639
77MP0001929_abnormal_gametogenesis0.67926631
78MP0001186_pigmentation_phenotype0.67711779
79MP0009840_abnormal_foam_cell0.67276272
80MP0000604_amyloidosis0.66116695
81MP0008007_abnormal_cellular_replicative0.65794541
82MP0000163_abnormal_cartilage_morphology0.65765521
83MP0003795_abnormal_bone_structure0.65164639
84MP0001835_abnormal_antigen_presentation0.65051470
85MP0000367_abnormal_coat/_hair0.62449203
86MP0000749_muscle_degeneration0.61354250
87MP0005165_increased_susceptibility_to0.60347310
88MP0009053_abnormal_anal_canal0.59156660
89MP0005193_abnormal_anterior_eye0.57939779
90MP0009931_abnormal_skin_appearance0.57434743
91MP0000358_abnormal_cell_content/0.56855264
92MP0003172_abnormal_lysosome_physiology0.56797844
93MP0004272_abnormal_basement_membrane0.55644223
94MP0003566_abnormal_cell_adhesion0.55494083
95MP0002269_muscular_atrophy0.55444636
96MP0002115_abnormal_skeleton_extremities0.54163742
97MP0002132_abnormal_respiratory_system0.51528224
98MP0002876_abnormal_thyroid_physiology0.50471512
99MP0002113_abnormal_skeleton_development0.49146118
100MP0001881_abnormal_mammary_gland0.48540648

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)7.33774482
2Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.66705991
3Metaphyseal dysplasia (HP:0100255)5.64237580
4Abnormality of the frontal sinuses (HP:0002687)4.67151637
5Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.47257194
6Metaphyseal cupping (HP:0003021)4.30510654
7Cupped ribs (HP:0000887)3.98912641
8Aplasia of the musculature (HP:0100854)3.92153666
9Abnormality of liposaccharide metabolism (HP:0010968)3.77845909
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.77845909
11Abnormality of glycolipid metabolism (HP:0010969)3.77845909
12Ulnar bowing (HP:0003031)3.76953657
13Small epiphyses (HP:0010585)3.57701066
14Onycholysis (HP:0001806)3.54543112
15Irregular vertebral endplates (HP:0003301)3.46882708
16Hypoplastic ischia (HP:0003175)3.42796149
17Radial bowing (HP:0002986)3.42456938
18Abnormality of nail color (HP:0100643)3.38718358
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34414636
20Enlarged epiphyses (HP:0010580)3.34001630
21Congenital ichthyosiform erythroderma (HP:0007431)3.33236786
22Atrophic scars (HP:0001075)3.28826710
23Spondylolisthesis (HP:0003302)3.27884327
24Flattened epiphyses (HP:0003071)3.17656749
25Spastic paraparesis (HP:0002313)3.16882268
26Protuberant abdomen (HP:0001538)3.12151514
27Abnormality of the vertebral endplates (HP:0005106)3.06188572
28Erythema (HP:0010783)2.93380449
29Partial duplication of the phalanx of hand (HP:0009999)2.92940850
30Ridged nail (HP:0001807)2.87676358
31Vertebral compression fractures (HP:0002953)2.82437791
32Fragile nails (HP:0001808)2.80050384
33Anomalous pulmonary venous return (HP:0010772)2.79470137
34Plantar hyperkeratosis (HP:0007556)2.74801106
35Interstitial pulmonary disease (HP:0006530)2.74594445
36Trismus (HP:0000211)2.71235953
37Prolonged neonatal jaundice (HP:0006579)2.70364070
38Severe visual impairment (HP:0001141)2.69013301
39Mild short stature (HP:0003502)2.68846327
40Abnormality of the ischium (HP:0003174)2.67621669
41Partial duplication of thumb phalanx (HP:0009944)2.62549427
42Disproportionate short-trunk short stature (HP:0003521)2.61862765
43Hypoplastic left heart (HP:0004383)2.58914115
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57044618
45Femoral bowing (HP:0002980)2.55460638
46Genu varum (HP:0002970)2.54826344
47Hypokinesia (HP:0002375)2.47164216
48Coxa vara (HP:0002812)2.45127675
49Abnormality of femoral epiphyses (HP:0006499)2.37471385
50Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.37471385
51J-shaped sella turcica (HP:0002680)2.37274348
52Patent foramen ovale (HP:0001655)2.33081524
53Abnormality of oral frenula (HP:0000190)2.33045381
54Osteolytic defects of the hand bones (HP:0009699)2.32429487
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.32429487
56Diminished motivation (HP:0000745)2.28955307
57Irregular epiphyses (HP:0010582)2.28933806
58Tibial bowing (HP:0002982)2.28670176
59Ankyloglossia (HP:0010296)2.28623727
60Osteoarthritis (HP:0002758)2.23332785
61Thick nail (HP:0001805)2.21386911
62Abnormality of the pulmonary veins (HP:0011718)2.21192147
63Palmoplantar hyperkeratosis (HP:0000972)2.21101912
64Bowing of the arm (HP:0006488)2.20695458
65Bowed forearm bones (HP:0003956)2.20695458
66White forelock (HP:0002211)2.18737266
67Cerebral inclusion bodies (HP:0100314)2.18612595
68Patchy hypopigmentation of hair (HP:0011365)2.12619962
69Abnormality of the distal phalanges of the toes (HP:0010182)2.12497811
70Short middle phalanx of the 5th finger (HP:0004220)2.11364551
71Termporal pattern (HP:0011008)2.10348487
72Insidious onset (HP:0003587)2.10348487
73Milia (HP:0001056)2.10039961
74Supranuclear gaze palsy (HP:0000605)2.07439855
75Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04919568
76Asymmetric septal hypertrophy (HP:0001670)2.02986012
77Palmar hyperkeratosis (HP:0010765)2.02839998
78Sensory axonal neuropathy (HP:0003390)2.02520298
79Vertebral hypoplasia (HP:0008417)2.01125737
80Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.01125737
81Ulnar claw (HP:0001178)2.00478160
82Abnormality of the thoracic spine (HP:0100711)1.95912341
83Progressive neurologic deterioration (HP:0002344)1.90843230
84Absent thumb (HP:0009777)1.90230579
85Hypoplasia of the fovea (HP:0007750)1.89567552
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.89567552
87Ocular albinism (HP:0001107)1.88891957
88Hypoplastic heart (HP:0001961)1.84153095
89Platyspondyly (HP:0000926)1.83332411
90Vitreoretinal degeneration (HP:0000655)1.82216872
91Abnormality of the acetabulum (HP:0003170)1.81928128
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81755680
93Flared metaphyses (HP:0003015)1.80948660
94Vascular calcification (HP:0004934)1.80291435
95Apathy (HP:0000741)1.79619698
96Persistence of primary teeth (HP:0006335)1.79371962
97Fragile skin (HP:0001030)1.77259103
98Nonimmune hydrops fetalis (HP:0001790)1.76234881
99Paraparesis (HP:0002385)1.74564875
100Abnormal vertebral ossification (HP:0100569)1.74195678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.35005829
2MST1R4.71698014
3MAP3K123.69690289
4PBK3.55589969
5TESK13.09722165
6NME22.73762154
7TYK22.62244676
8SCYL22.31201963
9PAK42.18114080
10MET2.13784839
11MAP3K32.10813326
12MST42.07025849
13FLT32.05190775
14MAP3K62.01216921
15IRAK21.70737353
16BCKDK1.70453077
17EIF2AK31.65652920
18TBK11.59668698
19STK381.56359800
20MYLK1.51881532
21DDR21.49515628
22FER1.42613346
23ABL21.37193576
24JAK11.33432788
25STK38L1.29794821
26IRAK31.24174879
27PLK41.23925623
28LATS11.20979756
29BUB11.19569146
30LATS21.19120887
31BMX1.14378908
32PTK21.12187927
33STK391.08119927
34PRKD31.06940776
35MAPKAPK31.05815442
36NUAK11.00813352
37MAP3K90.98559578
38INSRR0.96962489
39PAK20.95120835
40KIT0.94740387
41NME10.92728219
42MAP4K20.90928137
43EIF2AK10.89528586
44TRPM70.84839258
45ARAF0.84359321
46RPS6KB20.82378744
47MUSK0.80985492
48EIF2AK20.79998652
49DAPK10.79547488
50MAPK110.78971758
51PIM20.76681258
52MAP3K110.76148079
53MAP2K10.72704053
54ILK0.71025944
55MAP2K60.70707948
56MAP3K20.67420608
57VRK20.67292684
58KSR20.65020644
59MAP2K30.63367276
60ERN10.63026381
61VRK10.62154153
62LIMK10.62122120
63PKN20.61143329
64LMTK20.59868517
65PRKD20.58365319
66PRKCI0.58123806
67MAP3K50.57310738
68AKT20.56953133
69SIK10.56350066
70OXSR10.55645679
71CDK70.54936218
72TNK20.52270388
73PRKG20.51800754
74MAPKAPK50.50703970
75MAP2K70.50414066
76PRKCH0.50117055
77PTK2B0.49295730
78CSF1R0.45934650
79FGFR40.41885158
80RAF10.41815877
81ZAP700.39535427
82WEE10.39037110
83ICK0.38335364
84PAK60.37705340
85PINK10.37475240
86STK100.35395206
87PLK20.35264519
88NEK10.34696089
89PAK30.34315263
90AURKA0.33167491
91PRKCE0.31831328
92ROCK20.31554382
93IKBKE0.31400029
94ERBB40.31143232
95MTOR0.29948657
96PTK60.29493343
97RET0.29424601
98PDGFRA0.29348581
99BCR0.29142764
100PRKAA20.28154395

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.66393838
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.98934350
3Allograft rejection_Homo sapiens_hsa053302.74524173
4Other glycan degradation_Homo sapiens_hsa005112.72270023
5Lysosome_Homo sapiens_hsa041422.63160003
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.60490568
7Proteasome_Homo sapiens_hsa030502.49922247
8Type I diabetes mellitus_Homo sapiens_hsa049402.44734912
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09814882
10Folate biosynthesis_Homo sapiens_hsa007902.09436086
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08618679
12Circadian rhythm_Homo sapiens_hsa047102.07911438
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04312160
14Glutathione metabolism_Homo sapiens_hsa004801.98176045
15Galactose metabolism_Homo sapiens_hsa000521.94732274
16Sphingolipid metabolism_Homo sapiens_hsa006001.84823958
17Pentose phosphate pathway_Homo sapiens_hsa000301.74258385
18Influenza A_Homo sapiens_hsa051641.68268301
19Tyrosine metabolism_Homo sapiens_hsa003501.59412524
20Vibrio cholerae infection_Homo sapiens_hsa051101.56422152
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54206080
22Biosynthesis of amino acids_Homo sapiens_hsa012301.49873022
23Herpes simplex infection_Homo sapiens_hsa051681.49075442
24ECM-receptor interaction_Homo sapiens_hsa045121.48241010
25Pyrimidine metabolism_Homo sapiens_hsa002401.45930074
26Autoimmune thyroid disease_Homo sapiens_hsa053201.44702169
27Peroxisome_Homo sapiens_hsa041461.40179664
28Fatty acid elongation_Homo sapiens_hsa000621.39333027
29Fructose and mannose metabolism_Homo sapiens_hsa000511.39133750
30Phenylalanine metabolism_Homo sapiens_hsa003601.38720948
31Collecting duct acid secretion_Homo sapiens_hsa049661.38050488
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36604333
33Graft-versus-host disease_Homo sapiens_hsa053321.27399625
34Carbon metabolism_Homo sapiens_hsa012001.24480455
35Fatty acid biosynthesis_Homo sapiens_hsa000611.19980289
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14177244
37Antigen processing and presentation_Homo sapiens_hsa046121.12674558
38Protein digestion and absorption_Homo sapiens_hsa049741.08671032
39Butanoate metabolism_Homo sapiens_hsa006501.03693165
40Legionellosis_Homo sapiens_hsa051341.03199290
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01158492
42Selenocompound metabolism_Homo sapiens_hsa004501.00917406
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99260693
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98293184
45Rheumatoid arthritis_Homo sapiens_hsa053230.93783256
46Measles_Homo sapiens_hsa051620.93501859
47Arginine and proline metabolism_Homo sapiens_hsa003300.92202783
48Endocytosis_Homo sapiens_hsa041440.90892417
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87823838
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87620305
51Toxoplasmosis_Homo sapiens_hsa051450.84986898
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75662062
53Hepatitis C_Homo sapiens_hsa051600.74118534
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72491327
55Viral myocarditis_Homo sapiens_hsa054160.68981281
56Metabolic pathways_Homo sapiens_hsa011000.67710750
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.67603076
58Chemical carcinogenesis_Homo sapiens_hsa052040.67172814
59Phagosome_Homo sapiens_hsa041450.66951523
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.65834462
61Starch and sucrose metabolism_Homo sapiens_hsa005000.65428759
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65187762
63N-Glycan biosynthesis_Homo sapiens_hsa005100.65158306
64p53 signaling pathway_Homo sapiens_hsa041150.63553888
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61153061
66Synaptic vesicle cycle_Homo sapiens_hsa047210.57918592
67Arachidonic acid metabolism_Homo sapiens_hsa005900.57823434
68RNA transport_Homo sapiens_hsa030130.57399300
69Pertussis_Homo sapiens_hsa051330.54198850
70Apoptosis_Homo sapiens_hsa042100.52665875
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51485019
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50000856
73Amoebiasis_Homo sapiens_hsa051460.48943351
74Inositol phosphate metabolism_Homo sapiens_hsa005620.48938069
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47329423
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.46854554
77Proteoglycans in cancer_Homo sapiens_hsa052050.45184996
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44670645
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44251195
80Non-homologous end-joining_Homo sapiens_hsa034500.42825314
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42160337
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41746798
83Ovarian steroidogenesis_Homo sapiens_hsa049130.41687487
84Protein export_Homo sapiens_hsa030600.41286154
85Nucleotide excision repair_Homo sapiens_hsa034200.39984125
86African trypanosomiasis_Homo sapiens_hsa051430.39497150
87Ether lipid metabolism_Homo sapiens_hsa005650.38392880
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37220453
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.36995112
90Oxidative phosphorylation_Homo sapiens_hsa001900.36915006
91Malaria_Homo sapiens_hsa051440.36004935
92Asthma_Homo sapiens_hsa053100.34459656
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.34155785
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32745977
95Focal adhesion_Homo sapiens_hsa045100.30636649
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.30233332
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30153564
98Phototransduction_Homo sapiens_hsa047440.29018263
99Small cell lung cancer_Homo sapiens_hsa052220.28147724
100DNA replication_Homo sapiens_hsa030300.25763617

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