Rank | Gene Set | Z-score |
---|---|---|
1 | regulation of chronic inflammatory response (GO:0002676) | 4.30598680 |
2 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.27702463 |
3 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.25207119 |
4 | regulation of vitamin D biosynthetic process (GO:0060556) | 4.22348945 |
5 | immunoglobulin mediated immune response (GO:0016064) | 4.12702126 |
6 | type I interferon signaling pathway (GO:0060337) | 4.11276355 |
7 | cellular response to type I interferon (GO:0071357) | 4.11276355 |
8 | response to type I interferon (GO:0034340) | 4.08942417 |
9 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 4.00296830 |
10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.93271842 |
11 | NIK/NF-kappaB signaling (GO:0038061) | 3.91934602 |
12 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.83866589 |
13 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.82510955 |
14 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.77617584 |
15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.71500456 |
16 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.68178063 |
17 | negative regulation of interleukin-12 production (GO:0032695) | 3.64108219 |
18 | positive thymic T cell selection (GO:0045059) | 3.62548968 |
19 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.54158214 |
20 | regulation of vitamin metabolic process (GO:0030656) | 3.53305852 |
21 | T-helper 1 type immune response (GO:0042088) | 3.50571021 |
22 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.45368064 |
23 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.43041314 |
24 | regulation of T cell tolerance induction (GO:0002664) | 3.35896659 |
25 | positive regulation of type 2 immune response (GO:0002830) | 3.31536629 |
26 | regulation of regulatory T cell differentiation (GO:0045589) | 3.30927723 |
27 | positive regulation of humoral immune response (GO:0002922) | 3.22678026 |
28 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.21941764 |
29 | B cell mediated immunity (GO:0019724) | 3.17366245 |
30 | response to peptidoglycan (GO:0032494) | 3.15526253 |
31 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.14557775 |
32 | detection of bacterium (GO:0016045) | 3.12772635 |
33 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.11938183 |
34 | negative regulation of cell killing (GO:0031342) | 3.10265472 |
35 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.10265472 |
36 | germinal center formation (GO:0002467) | 3.08796170 |
37 | positive regulation of interleukin-17 production (GO:0032740) | 3.03687485 |
38 | myeloid dendritic cell differentiation (GO:0043011) | 3.03672549 |
39 | detection of other organism (GO:0098543) | 3.02600642 |
40 | positive regulation of antigen processing and presentation (GO:0002579) | 3.02358215 |
41 | regulation of antigen processing and presentation (GO:0002577) | 3.00159163 |
42 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.99419647 |
43 | positive regulation of isotype switching (GO:0045830) | 2.96238920 |
44 | thymic T cell selection (GO:0045061) | 2.95592494 |
45 | regulation of tolerance induction (GO:0002643) | 2.94489930 |
46 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.93747543 |
47 | macrophage activation involved in immune response (GO:0002281) | 2.92404842 |
48 | response to muramyl dipeptide (GO:0032495) | 2.90884020 |
49 | activation of MAPKKK activity (GO:0000185) | 2.90704870 |
50 | negative regulation of viral genome replication (GO:0045071) | 2.90587897 |
51 | T cell migration (GO:0072678) | 2.88408094 |
52 | positive regulation of tolerance induction (GO:0002645) | 2.87120984 |
53 | tolerance induction (GO:0002507) | 2.87069570 |
54 | cellular response to interferon-gamma (GO:0071346) | 2.86624728 |
55 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.85794225 |
56 | regulation of interferon-alpha production (GO:0032647) | 2.85489482 |
57 | regulation of interleukin-12 production (GO:0032655) | 2.85362565 |
58 | myeloid dendritic cell activation (GO:0001773) | 2.84773520 |
59 | defense response to protozoan (GO:0042832) | 2.84475914 |
60 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.83866389 |
61 | lymph node development (GO:0048535) | 2.83301308 |
62 | response to protozoan (GO:0001562) | 2.82666088 |
63 | regulation of gamma-delta T cell activation (GO:0046643) | 2.82357497 |
64 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.81684649 |
65 | T cell selection (GO:0045058) | 2.81611736 |
66 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.81433784 |
67 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.76374852 |
68 | regulation of mononuclear cell migration (GO:0071675) | 2.73886870 |
69 | regulation of chemokine biosynthetic process (GO:0045073) | 2.72577767 |
70 | positive regulation of defense response to virus by host (GO:0002230) | 2.71358627 |
71 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.68353889 |
72 | response to interferon-gamma (GO:0034341) | 2.67893467 |
73 | positive regulation of T-helper cell differentiation (GO:0045624) | 2.67778824 |
74 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.67422232 |
75 | regulation of T-helper cell differentiation (GO:0045622) | 2.66290392 |
76 | regulation of natural killer cell differentiation (GO:0032823) | 2.65865747 |
77 | regulation of type 2 immune response (GO:0002828) | 2.65438894 |
78 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.63610978 |
79 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.63156870 |
80 | positive regulation of B cell mediated immunity (GO:0002714) | 2.63115510 |
81 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.63115510 |
82 | positive T cell selection (GO:0043368) | 2.62239475 |
83 | positive regulation of interleukin-12 production (GO:0032735) | 2.60874601 |
84 | lymphocyte chemotaxis (GO:0048247) | 2.60824101 |
85 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.60623738 |
86 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.60283152 |
87 | regulation of isotype switching (GO:0045191) | 2.60141494 |
88 | negative thymic T cell selection (GO:0045060) | 2.59676702 |
89 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.58960607 |
90 | positive regulation of T cell differentiation (GO:0045582) | 2.58555553 |
91 | regulation of necroptotic process (GO:0060544) | 2.56491225 |
92 | regulation of T-helper 1 type immune response (GO:0002825) | 2.54336825 |
93 | regulation of defense response to virus by host (GO:0050691) | 2.53675748 |
94 | positive regulation of lymphocyte differentiation (GO:0045621) | 2.52472759 |
95 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.52195319 |
96 | interferon-gamma secretion (GO:0072643) | 2.51991930 |
97 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.50600513 |
98 | regulation of response to interferon-gamma (GO:0060330) | 2.50599708 |
99 | negative regulation of innate immune response (GO:0045824) | 2.50550131 |
100 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 2.49568373 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.53783074 |
2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.63046819 |
3 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.78799913 |
4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.17484603 |
5 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.16389175 |
6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.03163836 |
7 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.83886394 |
8 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.78421055 |
9 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.67709378 |
10 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.52068509 |
11 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.50188307 |
12 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.40886380 |
13 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.30026897 |
14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.27412539 |
15 | MYB_26560356_Chip-Seq_TH2_Human | 2.19311287 |
16 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.13047585 |
17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.09686688 |
18 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.05677879 |
19 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.04245563 |
20 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.03062330 |
21 | MAF_26560356_Chip-Seq_TH1_Human | 2.00350040 |
22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.99844667 |
23 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.98299818 |
24 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.92326456 |
25 | MYC_22102868_ChIP-Seq_BL_Human | 1.91744833 |
26 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.89741254 |
27 | MYB_26560356_Chip-Seq_TH1_Human | 1.83530933 |
28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.71554002 |
29 | UTX_26944678_Chip-Seq_JUKART_Human | 1.70851804 |
30 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.70181263 |
31 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.69933514 |
32 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.68597315 |
33 | MAF_26560356_Chip-Seq_TH2_Human | 1.66475180 |
34 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.60301764 |
35 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.59792248 |
36 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56677406 |
37 | SPI1_23127762_ChIP-Seq_K562_Human | 1.56095050 |
38 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.56017314 |
39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.55978331 |
40 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.55551344 |
41 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.52930955 |
42 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.51897819 |
43 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.50706334 |
44 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.45913182 |
45 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44353530 |
46 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.36026758 |
47 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.35559115 |
48 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.35450045 |
49 | GATA3_26560356_Chip-Seq_TH2_Human | 1.35333261 |
50 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.34486746 |
51 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.32792873 |
52 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32506874 |
53 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32384522 |
54 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.30720782 |
55 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.30708314 |
56 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.29411874 |
57 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.27338439 |
58 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.27128459 |
59 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.26710682 |
60 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.25688545 |
61 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.25262841 |
62 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.25230376 |
63 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.24251712 |
64 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.23833468 |
65 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.23054662 |
66 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.22266003 |
67 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.22248267 |
68 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.20373166 |
69 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17222584 |
70 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.17206860 |
71 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.16325103 |
72 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.16252672 |
73 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14864186 |
74 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.14208952 |
75 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.12543808 |
76 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.12376829 |
77 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.11536438 |
78 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.11240313 |
79 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09977348 |
80 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.07806648 |
81 | GATA1_22025678_ChIP-Seq_K562_Human | 1.06612524 |
82 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06140149 |
83 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.03916295 |
84 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.03538197 |
85 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.00638858 |
86 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.99906744 |
87 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.99280174 |
88 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.98033769 |
89 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.97872301 |
90 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96819370 |
91 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.96676731 |
92 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.94982042 |
93 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94917126 |
94 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.94285592 |
95 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.94017526 |
96 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.93922006 |
97 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.92221377 |
98 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90882318 |
99 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.89539667 |
100 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.89393244 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003303_peritoneal_inflammation | 4.43123262 |
2 | MP0003436_decreased_susceptibility_to | 3.56337438 |
3 | MP0005671_abnormal_response_to | 3.29922404 |
4 | MP0009785_altered_susceptibility_to | 3.17303905 |
5 | MP0001835_abnormal_antigen_presentation | 3.09063054 |
6 | MP0009840_abnormal_foam_cell | 3.08489769 |
7 | MP0002148_abnormal_hypersensitivity_rea | 2.99179666 |
8 | MP0003724_increased_susceptibility_to | 2.85565588 |
9 | MP0005000_abnormal_immune_tolerance | 2.80450743 |
10 | MP0005451_abnormal_body_composition | 2.80168307 |
11 | MP0005387_immune_system_phenotype | 2.71367767 |
12 | MP0001790_abnormal_immune_system | 2.71367767 |
13 | MP0003172_abnormal_lysosome_physiology | 2.61478027 |
14 | MP0001800_abnormal_humoral_immune | 2.61081491 |
15 | MP0000685_abnormal_immune_system | 2.49989131 |
16 | MP0009333_abnormal_splenocyte_physiolog | 2.46433663 |
17 | MP0005025_abnormal_response_to | 2.46149629 |
18 | MP0006082_CNS_inflammation | 2.39855132 |
19 | MP0002723_abnormal_immune_serum | 2.37811709 |
20 | MP0005058_abnormal_lysosome_morphology | 2.37330834 |
21 | MP0004510_myositis | 2.35571350 |
22 | MP0002452_abnormal_antigen_presenting | 2.31858099 |
23 | MP0003300_gastrointestinal_ulcer | 2.22557539 |
24 | MP0002419_abnormal_innate_immunity | 2.18881459 |
25 | MP0004947_skin_inflammation | 2.13169940 |
26 | MP0001819_abnormal_immune_cell | 2.03276668 |
27 | MP0003763_abnormal_thymus_physiology | 2.01971548 |
28 | MP0002420_abnormal_adaptive_immunity | 2.01445464 |
29 | MP0010155_abnormal_intestine_physiology | 1.99078796 |
30 | MP0001853_heart_inflammation | 1.98759536 |
31 | MP0002139_abnormal_hepatobiliary_system | 1.94015333 |
32 | MP0001533_abnormal_skeleton_physiology | 1.89633529 |
33 | MP0005310_abnormal_salivary_gland | 1.85960994 |
34 | MP0002405_respiratory_system_inflammati | 1.85085494 |
35 | MP0001845_abnormal_inflammatory_respons | 1.81877494 |
36 | MP0009764_decreased_sensitivity_to | 1.70472312 |
37 | MP0003191_abnormal_cellular_cholesterol | 1.60850470 |
38 | MP0008469_abnormal_protein_level | 1.57247126 |
39 | MP0000716_abnormal_immune_system | 1.56802453 |
40 | MP0002398_abnormal_bone_marrow | 1.53964908 |
41 | MP0003656_abnormal_erythrocyte_physiolo | 1.53861660 |
42 | MP0002933_joint_inflammation | 1.42320473 |
43 | MP0001873_stomach_inflammation | 1.41913133 |
44 | MP0003075_altered_response_to | 1.40468807 |
45 | MP0005464_abnormal_platelet_physiology | 1.36740480 |
46 | MP0003453_abnormal_keratinocyte_physiol | 1.36279811 |
47 | MP0002722_abnormal_immune_system | 1.30466029 |
48 | MP0002254_reproductive_system_inflammat | 1.30228272 |
49 | MP0002429_abnormal_blood_cell | 1.28629498 |
50 | MP0000689_abnormal_spleen_morphology | 1.27986987 |
51 | MP0002138_abnormal_hepatobiliary_system | 1.26926791 |
52 | MP0000858_altered_metastatic_potential | 1.26813509 |
53 | MP0009278_abnormal_bone_marrow | 1.26580492 |
54 | MP0003448_altered_tumor_morphology | 1.21770090 |
55 | MP0005360_urolithiasis | 1.19712827 |
56 | MP0002796_impaired_skin_barrier | 1.13970255 |
57 | MP0002998_abnormal_bone_remodeling | 1.13845250 |
58 | MP0000343_altered_response_to | 1.10342325 |
59 | MP0009763_increased_sensitivity_to | 1.03370653 |
60 | MP0002277_abnormal_respiratory_mucosa | 1.01434484 |
61 | MP0000604_amyloidosis | 1.00303942 |
62 | MP0005410_abnormal_fertilization | 0.99395785 |
63 | MP0003806_abnormal_nucleotide_metabolis | 0.98219130 |
64 | MP0000703_abnormal_thymus_morphology | 0.96827923 |
65 | MP0005390_skeleton_phenotype | 0.96468983 |
66 | MP0005397_hematopoietic_system_phenotyp | 0.94938515 |
67 | MP0001545_abnormal_hematopoietic_system | 0.94938515 |
68 | MP0002132_abnormal_respiratory_system | 0.94308011 |
69 | MP0000249_abnormal_blood_vessel | 0.91024133 |
70 | MP0005167_abnormal_blood-brain_barrier | 0.90036783 |
71 | MP0008007_abnormal_cellular_replicative | 0.89712026 |
72 | MP0003866_abnormal_defecation | 0.86876649 |
73 | MP0002332_abnormal_exercise_endurance | 0.85444973 |
74 | MP0005165_increased_susceptibility_to | 0.84509898 |
75 | MP0005166_decreased_susceptibility_to | 0.83978935 |
76 | MP0001216_abnormal_epidermal_layer | 0.83774838 |
77 | MP0004782_abnormal_surfactant_physiolog | 0.83565934 |
78 | MP0001348_abnormal_lacrimal_gland | 0.80247931 |
79 | MP0005319_abnormal_enzyme/_coenzyme | 0.79289253 |
80 | MP0005164_abnormal_response_to | 0.74582071 |
81 | MP0003828_pulmonary_edema | 0.73262411 |
82 | MP0009765_abnormal_xenobiotic_induced | 0.72744485 |
83 | MP0005023_abnormal_wound_healing | 0.70956256 |
84 | MP0008004_abnormal_stomach_pH | 0.70392821 |
85 | MP0000490_abnormal_crypts_of | 0.69293602 |
86 | MP0002166_altered_tumor_susceptibility | 0.68974362 |
87 | MP0001663_abnormal_digestive_system | 0.68658341 |
88 | MP0002006_tumorigenesis | 0.68024691 |
89 | MP0003195_calcinosis | 0.67990092 |
90 | MP0003091_abnormal_cell_migration | 0.65728979 |
91 | MP0004808_abnormal_hematopoietic_stem | 0.65059670 |
92 | MP0000678_abnormal_parathyroid_gland | 0.64806180 |
93 | MP0009643_abnormal_urine_homeostasis | 0.62809645 |
94 | MP0000609_abnormal_liver_physiology | 0.62707036 |
95 | MP0000681_abnormal_thyroid_gland | 0.62276041 |
96 | MP0002136_abnormal_kidney_physiology | 0.62246813 |
97 | MP0005647_abnormal_sex_gland | 0.59673371 |
98 | MP0005076_abnormal_cell_differentiation | 0.59143770 |
99 | MP0002019_abnormal_tumor_incidence | 0.58977675 |
100 | MP0009931_abnormal_skin_appearance | 0.56630568 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Decreased central vision (HP:0007663) | 5.32728301 |
2 | Cone-rod dystrophy (HP:0000548) | 4.24602526 |
3 | Orchitis (HP:0100796) | 4.03329525 |
4 | Myositis (HP:0100614) | 3.90034817 |
5 | Abnormality of glycolipid metabolism (HP:0010969) | 3.86778818 |
6 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.86778818 |
7 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.86778818 |
8 | Retrobulbar optic neuritis (HP:0100654) | 3.85339719 |
9 | Optic neuritis (HP:0100653) | 3.85339719 |
10 | Visual hallucinations (HP:0002367) | 3.82103832 |
11 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.73976996 |
12 | Increased IgM level (HP:0003496) | 3.52326915 |
13 | Pulmonary infiltrates (HP:0002113) | 3.45392636 |
14 | Mediastinal lymphadenopathy (HP:0100721) | 3.38200283 |
15 | Chest pain (HP:0100749) | 3.32442818 |
16 | Vasculitis (HP:0002633) | 3.22007796 |
17 | Dysostosis multiplex (HP:0000943) | 3.14913822 |
18 | Gastrointestinal infarctions (HP:0005244) | 3.13346597 |
19 | Gangrene (HP:0100758) | 3.10634966 |
20 | Parakeratosis (HP:0001036) | 3.06490005 |
21 | Stomatitis (HP:0010280) | 3.04896881 |
22 | Microvesicular hepatic steatosis (HP:0001414) | 3.03191850 |
23 | Autoimmune thrombocytopenia (HP:0001973) | 3.01089989 |
24 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.97847294 |
25 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.96436006 |
26 | Abnormality of T cell number (HP:0011839) | 2.94222830 |
27 | Keratoconjunctivitis sicca (HP:0001097) | 2.91251268 |
28 | Increased serum ferritin (HP:0003281) | 2.88763600 |
29 | Progressive neurologic deterioration (HP:0002344) | 2.86861312 |
30 | Pustule (HP:0200039) | 2.86113917 |
31 | Arterial thrombosis (HP:0004420) | 2.85887655 |
32 | Autoimmune hemolytic anemia (HP:0001890) | 2.83375352 |
33 | Recurrent viral infections (HP:0004429) | 2.83144266 |
34 | Abnormality of macrophages (HP:0004311) | 2.81452341 |
35 | Focal motor seizures (HP:0011153) | 2.81178951 |
36 | T lymphocytopenia (HP:0005403) | 2.78688461 |
37 | IgM deficiency (HP:0002850) | 2.76448996 |
38 | Recurrent bacterial skin infections (HP:0005406) | 2.75907358 |
39 | IgA deficiency (HP:0002720) | 2.75308986 |
40 | Increased corneal curvature (HP:0100692) | 2.74864040 |
41 | Keratoconus (HP:0000563) | 2.74864040 |
42 | Keratoconjunctivitis (HP:0001096) | 2.72918986 |
43 | Hemoptysis (HP:0002105) | 2.72135572 |
44 | Meningitis (HP:0001287) | 2.69897941 |
45 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.65923349 |
46 | Systemic lupus erythematosus (HP:0002725) | 2.65375756 |
47 | Increased cerebral lipofuscin (HP:0011813) | 2.64594250 |
48 | Eczematoid dermatitis (HP:0000976) | 2.62510928 |
49 | Recurrent abscess formation (HP:0002722) | 2.60618457 |
50 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.57334591 |
51 | Abnormality of the pleura (HP:0002103) | 2.53563689 |
52 | Thoracic kyphosis (HP:0002942) | 2.53555643 |
53 | Abnormality of the prostate (HP:0008775) | 2.51316501 |
54 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.47119781 |
55 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.47119781 |
56 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.47119781 |
57 | Unilateral renal agenesis (HP:0000122) | 2.43515255 |
58 | Chronic obstructive pulmonary disease (HP:0006510) | 2.43409099 |
59 | Obstructive lung disease (HP:0006536) | 2.43409099 |
60 | IgG deficiency (HP:0004315) | 2.42543762 |
61 | Mucopolysacchariduria (HP:0008155) | 2.40981987 |
62 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.40981987 |
63 | Acute hepatic failure (HP:0006554) | 2.40501001 |
64 | Recurrent fungal infections (HP:0002841) | 2.40385742 |
65 | Abnormality of iron homeostasis (HP:0011031) | 2.40235677 |
66 | Increased IgE level (HP:0003212) | 2.36444224 |
67 | Emphysema (HP:0002097) | 2.36259772 |
68 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.34596477 |
69 | Hypergammaglobulinemia (HP:0010702) | 2.33193033 |
70 | Encephalitis (HP:0002383) | 2.29145741 |
71 | Abnormality of the pericardium (HP:0001697) | 2.24906344 |
72 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.24229754 |
73 | Nasal polyposis (HP:0100582) | 2.18257913 |
74 | Interstitial pulmonary disease (HP:0006530) | 2.18074212 |
75 | Anorexia (HP:0002039) | 2.15743628 |
76 | Restrictive lung disease (HP:0002091) | 2.13216748 |
77 | Recurrent bronchitis (HP:0002837) | 2.12930999 |
78 | Abnormality of T cells (HP:0002843) | 2.12120314 |
79 | Urticaria (HP:0001025) | 2.11495112 |
80 | Glomerulopathy (HP:0100820) | 2.10537582 |
81 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.09717515 |
82 | Polyneuropathy (HP:0001271) | 2.09693078 |
83 | Amaurosis fugax (HP:0100576) | 2.09140981 |
84 | Gastrointestinal stroma tumor (HP:0100723) | 2.07286978 |
85 | Chronic diarrhea (HP:0002028) | 2.07183372 |
86 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.06802774 |
87 | Gingivitis (HP:0000230) | 2.06644479 |
88 | Recurrent skin infections (HP:0001581) | 2.06561550 |
89 | Joint swelling (HP:0001386) | 2.05814714 |
90 | Asymmetric septal hypertrophy (HP:0001670) | 2.05799222 |
91 | Beaking of vertebral bodies (HP:0004568) | 2.04785648 |
92 | Abnormality of the lumbar spine (HP:0100712) | 2.00111064 |
93 | Ureteral stenosis (HP:0000071) | 1.99524141 |
94 | Pulmonary fibrosis (HP:0002206) | 1.98865852 |
95 | Recurrent corneal erosions (HP:0000495) | 1.98668014 |
96 | Colitis (HP:0002583) | 1.97927152 |
97 | Epistaxis (HP:0000421) | 1.96708715 |
98 | Agammaglobulinemia (HP:0004432) | 1.93961208 |
99 | Granulocytopenia (HP:0001913) | 1.93928796 |
100 | Leukocytosis (HP:0001974) | 1.92629229 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TXK | 4.19870745 |
2 | IRAK3 | 4.17788580 |
3 | ERN1 | 3.60846418 |
4 | MAP3K14 | 3.56578707 |
5 | NME2 | 3.51052267 |
6 | MAP4K1 | 3.44875838 |
7 | IKBKB | 2.58217881 |
8 | PRPF4B | 2.57315751 |
9 | MATK | 2.41153600 |
10 | IRAK4 | 2.37052679 |
11 | TBK1 | 2.33721933 |
12 | RIPK4 | 2.14270799 |
13 | VRK2 | 2.01952593 |
14 | EPHA2 | 2.01949062 |
15 | TAOK2 | 1.98561843 |
16 | IKBKE | 1.98456487 |
17 | GRK7 | 1.87394591 |
18 | TYK2 | 1.83776345 |
19 | JAK3 | 1.75780466 |
20 | MAP3K13 | 1.63156393 |
21 | CSK | 1.61330867 |
22 | SMG1 | 1.51640432 |
23 | MST1R | 1.43555663 |
24 | PIM2 | 1.40719537 |
25 | FES | 1.38758500 |
26 | RIPK1 | 1.38509302 |
27 | BLK | 1.36435811 |
28 | DDR2 | 1.34513337 |
29 | TRPM7 | 1.34476267 |
30 | MAP3K11 | 1.30841597 |
31 | PBK | 1.29754227 |
32 | TAOK1 | 1.23896107 |
33 | ZAP70 | 1.20318910 |
34 | ADRBK2 | 1.14981675 |
35 | CDC42BPA | 1.12030051 |
36 | CHUK | 1.08575398 |
37 | MAPK11 | 1.08554185 |
38 | NME1 | 1.06571837 |
39 | SYK | 1.05768429 |
40 | ITK | 1.04772828 |
41 | BTK | 1.04337856 |
42 | MAP3K3 | 1.04053900 |
43 | DYRK1B | 1.02521965 |
44 | ICK | 1.01756954 |
45 | CSF1R | 0.97806887 |
46 | LYN | 0.91506994 |
47 | LCK | 0.90102589 |
48 | MAP2K3 | 0.87967172 |
49 | HCK | 0.84564617 |
50 | STK10 | 0.80338426 |
51 | HIPK2 | 0.76920709 |
52 | TESK2 | 0.75173451 |
53 | JAK1 | 0.74704069 |
54 | TGFBR2 | 0.70875038 |
55 | BMX | 0.69277323 |
56 | RPS6KL1 | 0.67595124 |
57 | RPS6KC1 | 0.67595124 |
58 | MOS | 0.66434686 |
59 | TRIB3 | 0.66312858 |
60 | KIT | 0.64806401 |
61 | TESK1 | 0.63344244 |
62 | JAK2 | 0.63340651 |
63 | PRKCQ | 0.61496411 |
64 | PIM1 | 0.59633604 |
65 | DAPK2 | 0.59616624 |
66 | FGFR4 | 0.58959659 |
67 | RPS6KA6 | 0.54570233 |
68 | FGR | 0.53561012 |
69 | IRAK2 | 0.51278506 |
70 | BMPR2 | 0.49221685 |
71 | MARK3 | 0.49049057 |
72 | CLK1 | 0.47195609 |
73 | GRK6 | 0.46647959 |
74 | MAP3K1 | 0.45524214 |
75 | MAP3K5 | 0.45011814 |
76 | DAPK1 | 0.44830664 |
77 | MAPK7 | 0.44129294 |
78 | SIK1 | 0.44011177 |
79 | TEC | 0.43657192 |
80 | CDK4 | 0.43198071 |
81 | ABL2 | 0.42432775 |
82 | TAOK3 | 0.40496574 |
83 | CDK12 | 0.39463458 |
84 | ARAF | 0.39205579 |
85 | PDK1 | 0.36881120 |
86 | NTRK1 | 0.35612662 |
87 | RPS6KA2 | 0.34580381 |
88 | IRAK1 | 0.34562569 |
89 | CDK6 | 0.34466618 |
90 | MAP2K6 | 0.34260872 |
91 | MAP2K2 | 0.34172188 |
92 | PDPK1 | 0.34137343 |
93 | ABL1 | 0.32411158 |
94 | SIK2 | 0.32192287 |
95 | TAF1 | 0.31131340 |
96 | PRKG2 | 0.30010688 |
97 | NEK9 | 0.29173894 |
98 | MET | 0.28886172 |
99 | MAPKAPK2 | 0.28647854 |
100 | EPHB1 | 0.28311992 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Allograft rejection_Homo sapiens_hsa05330 | 4.03120554 |
2 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.70557213 |
3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.42524731 |
4 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.17637049 |
5 | Asthma_Homo sapiens_hsa05310 | 3.13986696 |
6 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.81215408 |
7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.73782896 |
8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.57756940 |
9 | Leishmaniasis_Homo sapiens_hsa05140 | 2.52396741 |
10 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.47237396 |
11 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.40730071 |
12 | Other glycan degradation_Homo sapiens_hsa00511 | 2.37507085 |
13 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.30231837 |
14 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.23471959 |
15 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.18831098 |
16 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.15345441 |
17 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.11191587 |
18 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.93295659 |
19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.90139517 |
20 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.87370642 |
21 | Influenza A_Homo sapiens_hsa05164 | 1.81609516 |
22 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.76904348 |
23 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.75943369 |
24 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.67233841 |
25 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.64042015 |
26 | Measles_Homo sapiens_hsa05162 | 1.61126950 |
27 | Malaria_Homo sapiens_hsa05144 | 1.59367215 |
28 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.48405627 |
29 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.47964104 |
30 | Tuberculosis_Homo sapiens_hsa05152 | 1.44839782 |
31 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.43111693 |
32 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.38281594 |
33 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.35095653 |
34 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.31276169 |
35 | Lysosome_Homo sapiens_hsa04142 | 1.26474469 |
36 | Pertussis_Homo sapiens_hsa05133 | 1.21571686 |
37 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.20597566 |
38 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.20086438 |
39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.16622340 |
40 | Apoptosis_Homo sapiens_hsa04210 | 1.05578268 |
41 | Legionellosis_Homo sapiens_hsa05134 | 1.05125869 |
42 | Salmonella infection_Homo sapiens_hsa05132 | 1.04251662 |
43 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.04090671 |
44 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.03554070 |
45 | Shigellosis_Homo sapiens_hsa05131 | 0.95658776 |
46 | Hepatitis C_Homo sapiens_hsa05160 | 0.89149062 |
47 | Phototransduction_Homo sapiens_hsa04744 | 0.86269691 |
48 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.83925955 |
49 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79464172 |
50 | Hepatitis B_Homo sapiens_hsa05161 | 0.77315951 |
51 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.76044505 |
52 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.75122996 |
53 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.74389499 |
54 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.73514283 |
55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.70859759 |
56 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.69821925 |
57 | HTLV-I infection_Homo sapiens_hsa05166 | 0.62842794 |
58 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.61026975 |
59 | Prion diseases_Homo sapiens_hsa05020 | 0.57001865 |
60 | Phagosome_Homo sapiens_hsa04145 | 0.56681876 |
61 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.54737558 |
62 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49709108 |
63 | Bladder cancer_Homo sapiens_hsa05219 | 0.43356474 |
64 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.42287287 |
65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.42226358 |
66 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41854711 |
67 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.41172730 |
68 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.33895538 |
69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.32606079 |
70 | Proteasome_Homo sapiens_hsa03050 | 0.31315471 |
71 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.29692486 |
72 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.29584241 |
73 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.28306476 |
74 | Insulin resistance_Homo sapiens_hsa04931 | 0.28152072 |
75 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.26467814 |
76 | Purine metabolism_Homo sapiens_hsa00230 | 0.25566797 |
77 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.25146562 |
78 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.25012115 |
79 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.24997716 |
80 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.23654532 |
81 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.23406956 |
82 | Mineral absorption_Homo sapiens_hsa04978 | 0.23184876 |
83 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.22195047 |
84 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.21330273 |
85 | Endocytosis_Homo sapiens_hsa04144 | 0.20248806 |
86 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.19448075 |
87 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.17074793 |
88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.15944057 |
89 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.15600028 |
90 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.15434989 |
91 | Amoebiasis_Homo sapiens_hsa05146 | 0.15170419 |
92 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.14795005 |
93 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.14402844 |
94 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.12907481 |
95 | RNA polymerase_Homo sapiens_hsa03020 | 0.12733236 |
96 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.12029112 |
97 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.11586860 |
98 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.10470190 |
99 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.10286330 |
100 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.07528633 |