HCG4P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.45164032
2negative regulation of cell killing (GO:0031342)6.45164032
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.70098029
4positive regulation of gamma-delta T cell activation (GO:0046645)5.49978257
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.20449316
6antigen processing and presentation of endogenous antigen (GO:0019883)4.89101672
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80412051
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61931987
9leukocyte aggregation (GO:0070486)4.61280881
10negative regulation of interleukin-12 production (GO:0032695)4.46779309
11modulation by symbiont of host immune response (GO:0052553)4.39509778
12positive regulation by symbiont of host defense response (GO:0052509)4.39509778
13modulation by symbiont of host defense response (GO:0052031)4.39509778
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.39509778
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.39509778
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.39509778
17T cell migration (GO:0072678)4.33089367
18regulation of B cell receptor signaling pathway (GO:0050855)4.31749783
19neutrophil activation involved in immune response (GO:0002283)4.24596815
20response to peptidoglycan (GO:0032494)4.15583711
21detection of other organism (GO:0098543)4.15033552
22response to interleukin-15 (GO:0070672)4.10102085
23detection of bacterium (GO:0016045)4.04489298
24cellular response to interleukin-15 (GO:0071350)4.03601989
25regulation of gamma-delta T cell activation (GO:0046643)3.98185192
26response to muramyl dipeptide (GO:0032495)3.97496093
27tolerance induction (GO:0002507)3.95709983
28macrophage activation involved in immune response (GO:0002281)3.95159272
29cellular response to type I interferon (GO:0071357)3.89380139
30type I interferon signaling pathway (GO:0060337)3.89380139
31response to type I interferon (GO:0034340)3.86269637
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.84479034
33negative regulation of T cell mediated immunity (GO:0002710)3.77122196
34negative thymic T cell selection (GO:0045060)3.77003577
35immunoglobulin mediated immune response (GO:0016064)3.74361397
36cellular extravasation (GO:0045123)3.69980149
37negative T cell selection (GO:0043383)3.67241757
38neutrophil activation (GO:0042119)3.66421334
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63429242
40negative regulation of leukocyte mediated immunity (GO:0002704)3.62784822
41regulation of interferon-beta biosynthetic process (GO:0045357)3.61940113
42defense response to protozoan (GO:0042832)3.60943566
43germinal center formation (GO:0002467)3.59649950
44NIK/NF-kappaB signaling (GO:0038061)3.58343216
45regulation of alpha-beta T cell proliferation (GO:0046640)3.57077111
46granulocyte activation (GO:0036230)3.49198082
47regulation of T cell mediated cytotoxicity (GO:0001914)3.48254766
48positive thymic T cell selection (GO:0045059)3.37199931
49detection of external biotic stimulus (GO:0098581)3.36795679
50regulation of gamma-delta T cell differentiation (GO:0045586)3.34843572
51regulation of T cell tolerance induction (GO:0002664)3.32597424
52myeloid cell activation involved in immune response (GO:0002275)3.32163106
53negative regulation of innate immune response (GO:0045824)3.31840292
54response to protozoan (GO:0001562)3.30154295
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30134417
56interferon-gamma-mediated signaling pathway (GO:0060333)3.29805751
57respiratory burst (GO:0045730)3.26631857
58negative regulation of cytokine production involved in immune response (GO:0002719)3.19145718
59regulation of natural killer cell mediated immunity (GO:0002715)3.16797297
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16797297
61lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16356389
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14599616
63mast cell activation (GO:0045576)3.13771872
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.12750433
65regulation of tolerance induction (GO:0002643)3.11345719
66dendritic cell chemotaxis (GO:0002407)3.10228945
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09997320
68detection of molecule of bacterial origin (GO:0032490)3.08458921
69B cell receptor signaling pathway (GO:0050853)3.08338461
70regulation of interferon-alpha production (GO:0032647)3.07156775
71leukocyte degranulation (GO:0043299)3.05188957
72negative regulation of type 2 immune response (GO:0002829)3.04350187
73lymphocyte chemotaxis (GO:0048247)3.02816076
74regulation of mast cell degranulation (GO:0043304)3.02260513
75negative regulation of interleukin-6 production (GO:0032715)3.01360143
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01256576
77B cell mediated immunity (GO:0019724)3.00861441
78regulation of T-helper 1 cell differentiation (GO:0045625)3.00647455
79regulation of antigen processing and presentation (GO:0002577)2.99095825
80positive regulation of type 2 immune response (GO:0002830)2.98779036
81response to host immune response (GO:0052572)2.97614998
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97614998
83regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97056734
84detection of biotic stimulus (GO:0009595)2.96710400
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94177284
86positive regulation of interferon-alpha production (GO:0032727)2.93179880
87positive T cell selection (GO:0043368)2.92886810
88T cell selection (GO:0045058)2.91137186
89regulation of B cell differentiation (GO:0045577)2.89328454
90regulation of T-helper 2 cell differentiation (GO:0045628)2.88542857
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88214105
92regulation of type 2 immune response (GO:0002828)2.86997548
93thymic T cell selection (GO:0045061)2.86733683
94dendritic cell migration (GO:0036336)2.85876563
95regulation of cell killing (GO:0031341)2.85826169
96regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84993780
97leukocyte migration involved in inflammatory response (GO:0002523)2.83615202
98negative regulation of alpha-beta T cell activation (GO:0046636)2.83612258
99regulation of regulatory T cell differentiation (GO:0045589)2.83386879
100regulation of leukocyte degranulation (GO:0043300)2.82946986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85440704
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48967034
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36375017
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.23893121
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.01905283
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61128244
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39916071
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21485380
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05639796
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.04990565
11RUNX_20019798_ChIP-Seq_JUKART_Human2.93872995
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85434027
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64861268
14MYB_26560356_Chip-Seq_TH2_Human2.57930093
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56999833
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56369311
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51316474
18MAF_26560356_Chip-Seq_TH1_Human2.47458159
19VDR_21846776_ChIP-Seq_THP-1_Human2.42802793
20SPI1_23547873_ChIP-Seq_NB4_Human2.40856645
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37277233
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36394185
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31908310
24UTX_26944678_Chip-Seq_JUKART_Human2.29695259
25VDR_24763502_ChIP-Seq_THP-1_Human2.24894091
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22883441
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.20084717
28MYC_22102868_ChIP-Seq_BL_Human2.19861939
29SCL_19346495_ChIP-Seq_HPC-7_Human2.17831707
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15322840
31SPI1_23127762_ChIP-Seq_K562_Human2.13179932
32MYB_26560356_Chip-Seq_TH1_Human2.10124494
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.04205549
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02435392
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99896812
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95194517
37MAF_26560356_Chip-Seq_TH2_Human1.89294591
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83471275
39TCF7_22412390_ChIP-Seq_EML_Mouse1.83331288
40GATA3_27048872_Chip-Seq_THYMUS_Human1.78842538
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66140683
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64606494
43KDM2B_26808549_Chip-Seq_DND41_Human1.63699016
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62277537
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57458679
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57445617
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54273431
48VDR_24787735_ChIP-Seq_THP-1_Human1.54239292
49GATA3_26560356_Chip-Seq_TH2_Human1.53234562
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52686232
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52495279
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46525332
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45915231
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43594605
55GATA1_22025678_ChIP-Seq_K562_Human1.42115123
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40821548
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.40287391
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39155115
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38961088
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.36926868
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36888593
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.30730054
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30457536
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26935719
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25117379
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24336466
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24335048
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23961055
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21156272
70PU_27001747_Chip-Seq_BMDM_Mouse1.20855975
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17972819
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16931499
73LXR_22292898_ChIP-Seq_THP-1_Human1.16511457
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15967662
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14716376
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.13759373
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13523564
78BCL6_27268052_Chip-Seq_Bcells_Human1.13165358
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.11915308
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11457550
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.10488318
82GATA1_19941826_ChIP-Seq_K562_Human1.09743321
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09074460
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08611287
85BCOR_27268052_Chip-Seq_Bcells_Human1.05492529
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00793804
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00538022
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99714143
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97781159
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96716703
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93999563
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92268409
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89996053
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.87082830
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84100059
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83971042
97STAT1_20625510_ChIP-Seq_HELA_Human0.83500030
98SPI1_20517297_ChIP-Seq_HL60_Human0.83198561
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81706611
100NCOR1_26117541_ChIP-Seq_K562_Human0.78731762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.75731483
2MP0003436_decreased_susceptibility_to4.41796702
3MP0003303_peritoneal_inflammation4.14326937
4MP0005671_abnormal_response_to3.74474362
5MP0001835_abnormal_antigen_presentation3.63838692
6MP0005000_abnormal_immune_tolerance3.26024955
7MP0009785_altered_susceptibility_to3.25838369
8MP0001800_abnormal_humoral_immune3.07565016
9MP0001790_abnormal_immune_system3.04539547
10MP0005387_immune_system_phenotype3.04539547
11MP0002419_abnormal_innate_immunity2.93068809
12MP0005025_abnormal_response_to2.90876618
13MP0002723_abnormal_immune_serum2.79321525
14MP0002148_abnormal_hypersensitivity_rea2.78279767
15MP0000685_abnormal_immune_system2.70194146
16MP0002452_abnormal_antigen_presenting2.65919943
17MP0003763_abnormal_thymus_physiology2.61655206
18MP0006082_CNS_inflammation2.60389045
19MP0002420_abnormal_adaptive_immunity2.55654994
20MP0001819_abnormal_immune_cell2.54851110
21MP0003300_gastrointestinal_ulcer2.45722332
22MP0001533_abnormal_skeleton_physiology2.33123458
23MP0010155_abnormal_intestine_physiology2.15167156
24MP0009333_abnormal_splenocyte_physiolog2.08246057
25MP0004947_skin_inflammation2.06721928
26MP0002405_respiratory_system_inflammati2.03859841
27MP0002398_abnormal_bone_marrow1.95712988
28MP0000716_abnormal_immune_system1.94349796
29MP0001845_abnormal_inflammatory_respons1.92933487
30MP0004510_myositis1.81810956
31MP0009764_decreased_sensitivity_to1.77539047
32MP0005464_abnormal_platelet_physiology1.76324374
33MP0009278_abnormal_bone_marrow1.72554566
34MP0003191_abnormal_cellular_cholesterol1.65529502
35MP0003866_abnormal_defecation1.60422411
36MP0002722_abnormal_immune_system1.60409210
37MP0000689_abnormal_spleen_morphology1.59926431
38MP0008469_abnormal_protein_level1.55367413
39MP0000465_gastrointestinal_hemorrhage1.53377668
40MP0002429_abnormal_blood_cell1.51699201
41MP0000703_abnormal_thymus_morphology1.39030062
42MP0005310_abnormal_salivary_gland1.34775489
43MP0005058_abnormal_lysosome_morphology1.34462079
44MP0000858_altered_metastatic_potential1.33892275
45MP0003183_abnormal_peptide_metabolism1.32657222
46MP0005451_abnormal_body_composition1.30914509
47MP0003172_abnormal_lysosome_physiology1.29605319
48MP0002998_abnormal_bone_remodeling1.28533574
49MP0003075_altered_response_to1.22727374
50MP0003448_altered_tumor_morphology1.17362106
51MP0001873_stomach_inflammation1.16348399
52MP0008260_abnormal_autophagy1.16136311
53MP0004381_abnormal_hair_follicle1.15609957
54MP0001986_abnormal_taste_sensitivity1.15202343
55MP0001545_abnormal_hematopoietic_system1.14097837
56MP0005397_hematopoietic_system_phenotyp1.14097837
57MP0008004_abnormal_stomach_pH1.14068676
58MP0003656_abnormal_erythrocyte_physiolo1.12453656
59MP0002138_abnormal_hepatobiliary_system1.11377788
60MP0001853_heart_inflammation1.11207697
61MP0005166_decreased_susceptibility_to1.10760131
62MP0000343_altered_response_to1.10656657
63MP0001851_eye_inflammation1.07678466
64MP0003828_pulmonary_edema1.04393832
65MP0002277_abnormal_respiratory_mucosa1.04231733
66MP0002132_abnormal_respiratory_system1.01505824
67MP0004883_abnormal_blood_vessel1.00688673
68MP0002933_joint_inflammation0.99986023
69MP0005390_skeleton_phenotype0.98178204
70MP0003690_abnormal_glial_cell0.96053687
71MP0000604_amyloidosis0.94757652
72MP0009763_increased_sensitivity_to0.94305256
73MP0005164_abnormal_response_to0.92530271
74MP0009840_abnormal_foam_cell0.92185660
75MP0002166_altered_tumor_susceptibility0.85223304
76MP0001663_abnormal_digestive_system0.85194701
77MP0009765_abnormal_xenobiotic_induced0.84693459
78MP0002332_abnormal_exercise_endurance0.82681129
79MP0002396_abnormal_hematopoietic_system0.81836714
80MP0002006_tumorigenesis0.78705056
81MP0000490_abnormal_crypts_of0.75846927
82MP0005075_abnormal_melanosome_morpholog0.74714323
83MP0004130_abnormal_muscle_cell0.69880262
84MP0005167_abnormal_blood-brain_barrier0.67759342
85MP0000249_abnormal_blood_vessel0.64765996
86MP0003453_abnormal_keratinocyte_physiol0.63460406
87MP0003795_abnormal_bone_structure0.63416173
88MP0008874_decreased_physiological_sensi0.62360455
89MP0003806_abnormal_nucleotide_metabolis0.60567718
90MP0003045_fibrosis0.60307426
91MP0002254_reproductive_system_inflammat0.60078345
92MP0001542_abnormal_bone_strength0.58973171
93MP0001501_abnormal_sleep_pattern0.58813242
94MP0003091_abnormal_cell_migration0.55453752
95MP0003329_amyloid_beta_deposits0.52096299
96MP0000609_abnormal_liver_physiology0.50760685
97MP0004808_abnormal_hematopoietic_stem0.50459491
98MP0002019_abnormal_tumor_incidence0.49742028
99MP0002693_abnormal_pancreas_physiology0.48485777
100MP0005076_abnormal_cell_differentiation0.47778184

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.90710518
2Myositis (HP:0100614)6.18867220
3Orchitis (HP:0100796)5.86581849
4Retrobulbar optic neuritis (HP:0100654)5.80843684
5Optic neuritis (HP:0100653)5.80843684
6Recurrent bacterial skin infections (HP:0005406)5.37802669
7Recurrent abscess formation (HP:0002722)5.13440846
8Elevated erythrocyte sedimentation rate (HP:0003565)4.91952146
9Stomatitis (HP:0010280)4.91839208
10Abnormality of macrophages (HP:0004311)4.80870016
11Recurrent fungal infections (HP:0002841)4.16898535
12Keratoconjunctivitis sicca (HP:0001097)4.07573809
13Mediastinal lymphadenopathy (HP:0100721)3.98751359
14T lymphocytopenia (HP:0005403)3.95992883
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.92098987
16Recurrent gram-negative bacterial infections (HP:0005420)3.91181557
17Vasculitis (HP:0002633)3.83877868
18Abnormality of T cell number (HP:0011839)3.80234741
19Meningitis (HP:0001287)3.78038040
20Encephalitis (HP:0002383)3.76175942
21Keratoconjunctivitis (HP:0001096)3.75412925
22Gastrointestinal infarctions (HP:0005244)3.74127740
23Recurrent skin infections (HP:0001581)3.58317903
24Increased IgE level (HP:0003212)3.53613585
25Obstructive lung disease (HP:0006536)3.39481345
26Chronic obstructive pulmonary disease (HP:0006510)3.39481345
27Recurrent cutaneous fungal infections (HP:0011370)3.37766152
28Chronic mucocutaneous candidiasis (HP:0002728)3.37766152
29Panhypogammaglobulinemia (HP:0003139)3.32042706
30Pustule (HP:0200039)3.28337352
31Pulmonary infiltrates (HP:0002113)3.20337234
32Recurrent viral infections (HP:0004429)3.17554385
33Abnormality of T cells (HP:0002843)3.15667833
34Increased IgM level (HP:0003496)3.12710998
35Hemoptysis (HP:0002105)3.12647668
36Spontaneous hematomas (HP:0007420)3.01394151
37Leukocytosis (HP:0001974)2.95231056
38Urticaria (HP:0001025)2.91027523
39Abnormality of glycolipid metabolism (HP:0010969)2.90265098
40Abnormality of liposaccharide metabolism (HP:0010968)2.90265098
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.90265098
42Gangrene (HP:0100758)2.85859689
43Gingivitis (HP:0000230)2.85560907
44Arterial thrombosis (HP:0004420)2.85552430
45Chest pain (HP:0100749)2.82132631
46IgG deficiency (HP:0004315)2.78279259
47Inflammation of the large intestine (HP:0002037)2.78110436
48Joint swelling (HP:0001386)2.73807217
49Cellulitis (HP:0100658)2.73403242
50Prolonged bleeding time (HP:0003010)2.71884935
51Anorexia (HP:0002039)2.71654999
52Gastrointestinal inflammation (HP:0004386)2.68366455
53Gastrointestinal stroma tumor (HP:0100723)2.65065660
54Granulocytopenia (HP:0001913)2.64492391
55Severe combined immunodeficiency (HP:0004430)2.58977156
56Recurrent bronchitis (HP:0002837)2.58898203
57Hypergammaglobulinemia (HP:0010702)2.57725752
58Abnormality of T cell physiology (HP:0011840)2.57665469
59Pulmonary embolism (HP:0002204)2.56442400
60Lymphopenia (HP:0001888)2.55749098
61Agammaglobulinemia (HP:0004432)2.54501035
62Episodic fever (HP:0001954)2.52989800
63Petechiae (HP:0000967)2.52370845
64Colitis (HP:0002583)2.52258935
65Abnormality of the pleura (HP:0002103)2.50452257
66Autoimmune thrombocytopenia (HP:0001973)2.48562814
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.42378021
68Eosinophilia (HP:0001880)2.37351075
69Autoimmune hemolytic anemia (HP:0001890)2.36968569
70Abnormality of eosinophils (HP:0001879)2.35195840
71Stomach cancer (HP:0012126)2.35191488
72Epistaxis (HP:0000421)2.29273184
73Gingival bleeding (HP:0000225)2.28945466
74Increased serum ferritin (HP:0003281)2.27744376
75Increased cerebral lipofuscin (HP:0011813)2.27250308
76Acne (HP:0001061)2.24985780
77Glomerulopathy (HP:0100820)2.24154986
78Combined immunodeficiency (HP:0005387)2.22543800
79Sepsis (HP:0100806)2.21716811
80Hypochromic anemia (HP:0001931)2.20135358
81Osteomyelitis (HP:0002754)2.20006768
82Chronic otitis media (HP:0000389)2.19834143
83Purpura (HP:0000979)2.19308834
84Dysostosis multiplex (HP:0000943)2.18735460
85Abnormality of B cell number (HP:0010975)2.18731316
86Hematochezia (HP:0002573)2.18208298
87Arthralgia (HP:0002829)2.14718475
88IgM deficiency (HP:0002850)2.13633799
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10621346
90Loss of speech (HP:0002371)2.10570757
91Abnormality of the endocardium (HP:0004306)2.10273628
92Amyloidosis (HP:0011034)2.09296711
93Keratitis (HP:0000491)2.07100056
94Vacuolated lymphocytes (HP:0001922)2.06827180
95Vertigo (HP:0002321)2.05871471
96Premature loss of primary teeth (HP:0006323)2.03929403
97Polyneuropathy (HP:0001271)2.03862423
98Interstitial pulmonary disease (HP:0006530)2.02776118
99Restrictive lung disease (HP:0002091)2.01539874
100Verrucae (HP:0200043)2.00177922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.31783116
2MAP4K14.23069870
3TXK3.29678178
4MAP3K143.04939560
5IRAK43.03780124
6TYK22.84744874
7BLK2.68091948
8GRK62.38663070
9IKBKE2.34939412
10CSK2.34788467
11ZAP702.34432108
12TBK12.34113356
13PRPF4B2.30504951
14TAOK32.20597257
15ERN12.12625822
16FES1.99419942
17TNK21.99279969
18MAP3K131.98438733
19JAK31.92473250
20JAK11.82711330
21MAP2K31.79063969
22FGR1.78016681
23IKBKB1.75318147
24BTK1.75217477
25SYK1.67090744
26BMPR21.56239406
27SIK31.54934994
28IRAK31.53918727
29MAP3K111.51564632
30HCK1.45442387
31RIPK11.44972104
32TAOK11.42293864
33LYN1.35480734
34EPHB11.34567331
35MAP3K31.32104234
36LCK1.31247796
37JAK21.24400351
38GRK71.22939761
39MATK1.22757809
40TAOK21.21942890
41MARK31.19809816
42CSF1R1.17678003
43ITK1.13261877
44KIT1.05666500
45SIK21.01851748
46IRAK10.97978826
47MAP3K10.96801135
48IRAK20.94245135
49TESK20.89807275
50MARK20.86742032
51STK100.84249734
52CDC42BPA0.82905111
53PRKD20.79384317
54TEC0.77610600
55PDK10.76187433
56PIM10.74501881
57MAP2K20.73945315
58MAP3K70.73301468
59MAPK70.72812264
60TRIB30.71884543
61CHUK0.71323799
62KSR20.66784079
63FGFR40.65576761
64FYN0.59049057
65PTK60.54655042
66PRKCQ0.54385808
67HIPK20.52959603
68TGFBR20.52846233
69MOS0.51499223
70MAPK120.51380135
71SIK10.50638532
72PDPK10.50547874
73RPS6KL10.46744378
74RPS6KC10.46744378
75YES10.43247432
76EPHA30.41573773
77MAP3K50.40814234
78RPS6KA60.40344198
79SMG10.40336977
80CDK40.39092201
81MAPK40.38217984
82DYRK1B0.36498415
83FGFR30.35098831
84MAP2K60.34345714
85PIK3CG0.32956274
86NLK0.32657487
87ADRBK20.31358348
88MAPK110.30595198
89CAMKK10.30500802
90LRRK20.28821160
91ABL10.28087383
92MAPKAPK20.27919413
93RPS6KA20.27644422
94CAMKK20.26190708
95CLK10.25974673
96NME20.25832073
97BMX0.25662383
98SGK30.25139074
99RPS6KA10.24518583
100PDGFRB0.24136878

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.85728319
2Graft-versus-host disease_Homo sapiens_hsa053322.85258022
3Allograft rejection_Homo sapiens_hsa053302.83574266
4Leishmaniasis_Homo sapiens_hsa051402.81970885
5Primary immunodeficiency_Homo sapiens_hsa053402.77161233
6Autoimmune thyroid disease_Homo sapiens_hsa053202.46458965
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.39850953
8Staphylococcus aureus infection_Homo sapiens_hsa051502.36712347
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36419091
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35985702
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27684900
12B cell receptor signaling pathway_Homo sapiens_hsa046622.25574296
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14267815
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.09253840
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06372740
16Type I diabetes mellitus_Homo sapiens_hsa049402.02894219
17T cell receptor signaling pathway_Homo sapiens_hsa046601.95361147
18Measles_Homo sapiens_hsa051621.93283010
19Tuberculosis_Homo sapiens_hsa051521.90765524
20Malaria_Homo sapiens_hsa051441.90633636
21TNF signaling pathway_Homo sapiens_hsa046681.82182467
22Asthma_Homo sapiens_hsa053101.76545625
23Antigen processing and presentation_Homo sapiens_hsa046121.74946081
24Hematopoietic cell lineage_Homo sapiens_hsa046401.67658115
25Influenza A_Homo sapiens_hsa051641.64255430
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64062543
27African trypanosomiasis_Homo sapiens_hsa051431.63541885
28Toxoplasmosis_Homo sapiens_hsa051451.58706599
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55709422
30Herpes simplex infection_Homo sapiens_hsa051681.55512242
31Acute myeloid leukemia_Homo sapiens_hsa052211.54907506
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.52969731
33Chemokine signaling pathway_Homo sapiens_hsa040621.52475714
34Legionellosis_Homo sapiens_hsa051341.50806215
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47854704
36Other glycan degradation_Homo sapiens_hsa005111.47282608
37Viral myocarditis_Homo sapiens_hsa054161.46390831
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45642067
39Rheumatoid arthritis_Homo sapiens_hsa053231.43336375
40Pertussis_Homo sapiens_hsa051331.33309346
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23437954
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23183385
43Hepatitis B_Homo sapiens_hsa051611.18924696
44Hepatitis C_Homo sapiens_hsa051601.18085366
45Apoptosis_Homo sapiens_hsa042101.04884110
46Salmonella infection_Homo sapiens_hsa051321.03142588
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.95511342
48Phagosome_Homo sapiens_hsa041450.95454794
49Non-small cell lung cancer_Homo sapiens_hsa052230.94826051
50Shigellosis_Homo sapiens_hsa051310.92378517
51Lysosome_Homo sapiens_hsa041420.88832092
52VEGF signaling pathway_Homo sapiens_hsa043700.88337893
53Epstein-Barr virus infection_Homo sapiens_hsa051690.83808368
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83432894
55Prolactin signaling pathway_Homo sapiens_hsa049170.81576426
56Platelet activation_Homo sapiens_hsa046110.77216455
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75286932
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72597419
59Chronic myeloid leukemia_Homo sapiens_hsa052200.69943634
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.68646896
61Pancreatic cancer_Homo sapiens_hsa052120.68151071
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.67634719
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.65069530
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62693026
65Viral carcinogenesis_Homo sapiens_hsa052030.59521287
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.58186498
67HTLV-I infection_Homo sapiens_hsa051660.58087061
68Amoebiasis_Homo sapiens_hsa051460.57960791
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56282150
70Endocytosis_Homo sapiens_hsa041440.54720510
71Notch signaling pathway_Homo sapiens_hsa043300.53148277
72Type II diabetes mellitus_Homo sapiens_hsa049300.51824914
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.51767083
74Renal cell carcinoma_Homo sapiens_hsa052110.51091244
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49423785
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49082113
77FoxO signaling pathway_Homo sapiens_hsa040680.48352970
78Insulin resistance_Homo sapiens_hsa049310.47054100
79Dorso-ventral axis formation_Homo sapiens_hsa043200.45856357
80Choline metabolism in cancer_Homo sapiens_hsa052310.45447644
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42419493
82MAPK signaling pathway_Homo sapiens_hsa040100.42163338
83mTOR signaling pathway_Homo sapiens_hsa041500.38400488
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37561338
85GnRH signaling pathway_Homo sapiens_hsa049120.36951734
86Arachidonic acid metabolism_Homo sapiens_hsa005900.36329356
87HIF-1 signaling pathway_Homo sapiens_hsa040660.36280133
88Endometrial cancer_Homo sapiens_hsa052130.35088632
89Colorectal cancer_Homo sapiens_hsa052100.34437196
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33161420
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32611159
92Rap1 signaling pathway_Homo sapiens_hsa040150.32218949
93Inositol phosphate metabolism_Homo sapiens_hsa005620.30841019
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.27602343
95Prion diseases_Homo sapiens_hsa050200.25088640
96Prostate cancer_Homo sapiens_hsa052150.24860046
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21278204
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20630163
99Small cell lung cancer_Homo sapiens_hsa052220.18585660
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18040013

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