HCG4P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.02197070
2cytidine catabolic process (GO:0006216)8.02197070
3cytidine deamination (GO:0009972)8.02197070
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.94773018
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.83821365
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.14605272
7DNA deamination (GO:0045006)6.31705943
8negative T cell selection (GO:0043383)6.18421595
9Arp2/3 complex-mediated actin nucleation (GO:0034314)6.15046577
10T cell migration (GO:0072678)5.87216731
11positive T cell selection (GO:0043368)5.69540883
12positive thymic T cell selection (GO:0045059)5.50330401
13positive regulation of gamma-delta T cell activation (GO:0046645)5.40252824
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34998978
15actin nucleation (GO:0045010)5.30251341
16negative thymic T cell selection (GO:0045060)5.16030503
17antigen processing and presentation of endogenous antigen (GO:0019883)5.11876049
18cellular response to interleukin-15 (GO:0071350)5.11316311
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.94860632
20negative regulation of cell killing (GO:0031342)4.94860632
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.91213798
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88573853
23thymic T cell selection (GO:0045061)4.81418304
24regulation of T cell tolerance induction (GO:0002664)4.80344604
25regulation of B cell receptor signaling pathway (GO:0050855)4.68937364
26positive regulation of T cell mediated cytotoxicity (GO:0001916)4.62758789
27positive regulation of B cell differentiation (GO:0045579)4.62527484
28T cell selection (GO:0045058)4.52106974
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.48921948
30regulation of gamma-delta T cell differentiation (GO:0045586)4.43541653
31positive regulation of tolerance induction (GO:0002645)4.42814876
32response to interleukin-15 (GO:0070672)4.39604305
33regulation of activation of Janus kinase activity (GO:0010533)4.31999594
34negative regulation of viral genome replication (GO:0045071)4.26009901
35regulation of regulatory T cell differentiation (GO:0045589)4.25134282
36regulation of tolerance induction (GO:0002643)4.24683279
37cytolysis (GO:0019835)4.19987119
38regulation of gamma-delta T cell activation (GO:0046643)4.13596618
39respiratory burst (GO:0045730)4.07995539
40negative regulation of stress fiber assembly (GO:0051497)4.07551643
41regulation of T cell mediated cytotoxicity (GO:0001914)4.05742689
42positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.03492320
43immunoglobulin mediated immune response (GO:0016064)4.01308869
44regulation of natural killer cell mediated immunity (GO:0002715)3.98326943
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.98326943
46regulation of B cell differentiation (GO:0045577)3.95286926
47negative regulation of T cell apoptotic process (GO:0070233)3.94732370
48leukocyte aggregation (GO:0070486)3.94309945
49positive regulation of interleukin-4 production (GO:0032753)3.92351411
50T cell receptor signaling pathway (GO:0050852)3.90773829
51regulation of alpha-beta T cell proliferation (GO:0046640)3.82211254
52positive regulation of calcium-mediated signaling (GO:0050850)3.78926836
53type I interferon signaling pathway (GO:0060337)3.76198466
54cellular response to type I interferon (GO:0071357)3.76198466
55positive regulation of alpha-beta T cell proliferation (GO:0046641)3.75091144
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.72926204
57T cell costimulation (GO:0031295)3.72643376
58sequestering of actin monomers (GO:0042989)3.72181773
59pyrimidine nucleoside catabolic process (GO:0046135)3.71569676
60response to pheromone (GO:0019236)3.71427846
61response to type I interferon (GO:0034340)3.68645402
62lymphocyte costimulation (GO:0031294)3.67458211
63positive regulation of cell killing (GO:0031343)3.64811962
64positive regulation of monocyte chemotaxis (GO:0090026)3.56651387
65cellular defense response (GO:0006968)3.56009588
66antigen receptor-mediated signaling pathway (GO:0050851)3.52871147
67positive regulation of interleukin-8 secretion (GO:2000484)3.48386287
68lymphocyte migration (GO:0072676)3.46740885
69antigen processing and presentation via MHC class Ib (GO:0002475)3.45172094
70positive regulation of natural killer cell mediated immunity (GO:0002717)3.45103871
71regulation of cell killing (GO:0031341)3.41417044
72lymphocyte chemotaxis (GO:0048247)3.40820680
73positive regulation of T cell mediated immunity (GO:0002711)3.36614101
74regulation of interleukin-2 biosynthetic process (GO:0045076)3.32080237
75negative regulation of phagocytosis (GO:0050765)3.31203144
76regulation of interleukin-4 production (GO:0032673)3.31061075
77regulation of defense response to virus by virus (GO:0050690)3.23654679
78B cell mediated immunity (GO:0019724)3.19876806
79response to interferon-beta (GO:0035456)3.19488834
80dendritic cell chemotaxis (GO:0002407)3.19314613
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.11661749
82negative regulation of calcium ion transport into cytosol (GO:0010523)3.10972264
83positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.09355564
84regulation of T cell chemotaxis (GO:0010819)3.08636718
85positive regulation of T cell chemotaxis (GO:0010820)3.08636718
86B cell receptor signaling pathway (GO:0050853)3.02269136
87glucosamine-containing compound catabolic process (GO:1901072)3.01979749
88production of molecular mediator involved in inflammatory response (GO:0002532)3.01231709
89positive regulation of lamellipodium assembly (GO:0010592)3.00941058
90regulation of viral genome replication (GO:0045069)3.00048560
91cell wall macromolecule metabolic process (GO:0044036)2.98008543
92positive regulation of chemokine secretion (GO:0090197)2.97154563
93negative regulation of leukocyte mediated immunity (GO:0002704)2.96556620
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95750871
95neutrophil activation (GO:0042119)2.94745568
96negative regulation of lymphocyte apoptotic process (GO:0070229)2.92337051
97chemokine-mediated signaling pathway (GO:0070098)2.91307299
98negative regulation of actin filament bundle assembly (GO:0032232)2.89027703
99regulation of T cell mediated immunity (GO:0002709)2.88939027
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86687673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.21099268
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.18510831
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.91897319
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.04860726
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79336595
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.44785296
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34370676
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32336173
9MYB_26560356_Chip-Seq_TH2_Human3.32180810
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10722769
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.85598095
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76462642
13RUNX_20019798_ChIP-Seq_JUKART_Human2.74914779
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71567350
15UTX_26944678_Chip-Seq_JUKART_Human2.67168764
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57396158
17MAF_26560356_Chip-Seq_TH1_Human2.56733371
18MYB_26560356_Chip-Seq_TH1_Human2.52603667
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43205811
20MAF_26560356_Chip-Seq_TH2_Human2.40617816
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34239600
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29717054
23GATA3_27048872_Chip-Seq_THYMUS_Human2.21314251
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97264342
25BCL6_27268052_Chip-Seq_Bcells_Human1.89453684
26SPI1_23547873_ChIP-Seq_NB4_Human1.89344247
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84287163
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83146547
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82444853
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.75859699
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75653398
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74108665
33GATA3_26560356_Chip-Seq_TH2_Human1.67791742
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65962446
35VDR_24763502_ChIP-Seq_THP-1_Human1.58226846
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.56735191
37SPI1_23127762_ChIP-Seq_K562_Human1.54331429
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53091994
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52990390
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52342215
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51436104
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50724184
43LXR_22292898_ChIP-Seq_THP-1_Human1.50278344
44VDR_21846776_ChIP-Seq_THP-1_Human1.48645039
45BCOR_27268052_Chip-Seq_Bcells_Human1.45443491
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45073870
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.42574613
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.38140023
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37171464
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.34611295
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29270144
52CIITA_25753668_ChIP-Seq_RAJI_Human1.28476617
53MYC_22102868_ChIP-Seq_BL_Human1.26968249
54P68_20966046_ChIP-Seq_HELA_Human1.24594009
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23444552
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17881806
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17405658
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14516889
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.13091807
60E2F1_20622854_ChIP-Seq_HELA_Human1.11266442
61P300_27268052_Chip-Seq_Bcells_Human1.08845748
62SA1_27219007_Chip-Seq_Bcells_Human1.08335458
63SPI1_20517297_ChIP-Seq_HL60_Human1.08034511
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06330808
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05107495
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03469684
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03306262
68CTCF_20526341_ChIP-Seq_ESCs_Human1.02329005
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01803126
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01364257
71PHF8_20622854_ChIP-Seq_HELA_Human1.00005749
72TAF2_19829295_ChIP-Seq_ESCs_Human0.99766705
73CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99276322
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99198750
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97177660
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97081581
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96003349
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94299748
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93931908
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92933009
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91403582
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.91129370
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90443003
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90399656
85ETS1_21867929_ChIP-Seq_TH2_Mouse0.89613399
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.88935167
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88710028
88ERA_21632823_ChIP-Seq_H3396_Human0.87943257
89RAC3_21632823_ChIP-Seq_H3396_Human0.87300806
90NANOG_20526341_ChIP-Seq_ESCs_Human0.86671104
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86632136
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85824650
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83773847
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83027929
95STAT1_20625510_ChIP-Seq_HELA_Human0.82898428
96VDR_23849224_ChIP-Seq_CD4+_Human0.81184649
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79727437
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.79690521
99KDM2B_26808549_Chip-Seq_DND41_Human0.79497925
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78984056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.23841895
2MP0001835_abnormal_antigen_presentation4.09663796
3MP0009785_altered_susceptibility_to3.78731187
4MP0003763_abnormal_thymus_physiology3.35330018
5MP0003436_decreased_susceptibility_to3.15294843
6MP0005025_abnormal_response_to3.12432787
7MP0005000_abnormal_immune_tolerance3.08816209
8MP0001800_abnormal_humoral_immune2.94517336
9MP0009333_abnormal_splenocyte_physiolog2.88360421
10MP0002420_abnormal_adaptive_immunity2.85348878
11MP0001819_abnormal_immune_cell2.77976135
12MP0002723_abnormal_immune_serum2.75988929
13MP0002166_altered_tumor_susceptibility2.72961320
14MP0006082_CNS_inflammation2.70482023
15MP0000685_abnormal_immune_system2.51414190
16MP0002452_abnormal_antigen_presenting2.44772439
17MP0002419_abnormal_innate_immunity2.42824557
18MP0005387_immune_system_phenotype2.36379865
19MP0001790_abnormal_immune_system2.36379865
20MP0003866_abnormal_defecation2.33344667
21MP0002148_abnormal_hypersensitivity_rea2.26016868
22MP0003724_increased_susceptibility_to2.25425836
23MP0000716_abnormal_immune_system2.17822526
24MP0002398_abnormal_bone_marrow2.16767154
25MP0002405_respiratory_system_inflammati2.06811805
26MP0010155_abnormal_intestine_physiology1.95253720
27MP0002006_tumorigenesis1.92439962
28MP0000703_abnormal_thymus_morphology1.92142640
29MP0001873_stomach_inflammation1.84681912
30MP0001845_abnormal_inflammatory_respons1.84041865
31MP0003878_abnormal_ear_physiology1.82051040
32MP0005377_hearing/vestibular/ear_phenot1.82051040
33MP0003448_altered_tumor_morphology1.78953342
34MP0002722_abnormal_immune_system1.78393354
35MP0005410_abnormal_fertilization1.73474568
36MP0000689_abnormal_spleen_morphology1.67016228
37MP0002429_abnormal_blood_cell1.65411507
38MP0008469_abnormal_protein_level1.54156863
39MP0000858_altered_metastatic_potential1.49808462
40MP0005464_abnormal_platelet_physiology1.46675595
41MP0002877_abnormal_melanocyte_morpholog1.42544886
42MP0004947_skin_inflammation1.40865131
43MP0001533_abnormal_skeleton_physiology1.33327008
44MP0005310_abnormal_salivary_gland1.30767628
45MP0002132_abnormal_respiratory_system1.28600858
46MP0008260_abnormal_autophagy1.27465949
47MP0002933_joint_inflammation1.24300877
48MP0001853_heart_inflammation1.22866021
49MP0003045_fibrosis1.20444716
50MP0005166_decreased_susceptibility_to1.19708742
51MP0009763_increased_sensitivity_to1.17165760
52MP0003183_abnormal_peptide_metabolism1.13076226
53MP0000604_amyloidosis1.09523883
54MP0003806_abnormal_nucleotide_metabolis1.07405770
55MP0009764_decreased_sensitivity_to1.03415864
56MP0003300_gastrointestinal_ulcer1.01570442
57MP0008961_abnormal_basal_metabolism0.98350804
58MP0004381_abnormal_hair_follicle0.98042034
59MP0003075_altered_response_to0.95521971
60MP0002138_abnormal_hepatobiliary_system0.94034837
61MP0002693_abnormal_pancreas_physiology0.93611186
62MP0001485_abnormal_pinna_reflex0.92417477
63MP0002277_abnormal_respiratory_mucosa0.91723098
64MP0003303_peritoneal_inflammation0.90150259
65MP0002638_abnormal_pupillary_reflex0.82320835
66MP0005075_abnormal_melanosome_morpholog0.81599016
67MP0003646_muscle_fatigue0.78442403
68MP0008995_early_reproductive_senescence0.75634163
69MP0003786_premature_aging0.73842158
70MP0003191_abnormal_cellular_cholesterol0.70922636
71MP0002019_abnormal_tumor_incidence0.69361786
72MP0002998_abnormal_bone_remodeling0.68002359
73MP0002653_abnormal_ependyma_morphology0.67677445
74MP0001765_abnormal_ion_homeostasis0.67277620
75MP0003137_abnormal_impulse_conducting0.67031273
76MP0000678_abnormal_parathyroid_gland0.66804579
77MP0003172_abnormal_lysosome_physiology0.63595722
78MP0000681_abnormal_thyroid_gland0.62716856
79MP0005451_abnormal_body_composition0.61881506
80MP0000372_irregular_coat_pigmentation0.61727704
81MP0000920_abnormal_myelination0.58338200
82MP0002009_preneoplasia0.55225830
83MP0005623_abnormal_meninges_morphology0.54825527
84MP0004145_abnormal_muscle_electrophysio0.53753119
85MP0000639_abnormal_adrenal_gland0.52909861
86MP0001542_abnormal_bone_strength0.51982801
87MP0002095_abnormal_skin_pigmentation0.51743167
88MP0008873_increased_physiological_sensi0.51615441
89MP0000490_abnormal_crypts_of0.51339041
90MP0001919_abnormal_reproductive_system0.51117809
91MP0001986_abnormal_taste_sensitivity0.51016109
92MP0003795_abnormal_bone_structure0.50612722
93MP0009765_abnormal_xenobiotic_induced0.50432750
94MP0005390_skeleton_phenotype0.49589899
95MP0005379_endocrine/exocrine_gland_phen0.49219564
96MP0002163_abnormal_gland_morphology0.48592489
97MP0005584_abnormal_enzyme/coenzyme_acti0.47992745
98MP0004510_myositis0.47211030
99MP0005636_abnormal_mineral_homeostasis0.45621928
100MP0002136_abnormal_kidney_physiology0.45384365

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.40165569
2Aplastic anemia (HP:0001915)6.04337912
3Abnormality of T cell number (HP:0011839)5.63168419
4Elevated erythrocyte sedimentation rate (HP:0003565)5.56104531
5Abnormality of macrophages (HP:0004311)4.71358577
6Abnormality of T cells (HP:0002843)4.38829074
7Hypoproteinemia (HP:0003075)4.24331380
8Chronic diarrhea (HP:0002028)4.21064157
9Myositis (HP:0100614)4.09508249
10Eczematoid dermatitis (HP:0000976)4.02884177
11Optic neuritis (HP:0100653)4.01503395
12Retrobulbar optic neuritis (HP:0100654)4.01503395
13Encephalitis (HP:0002383)3.84067405
14Severe combined immunodeficiency (HP:0004430)3.81729118
15IgG deficiency (HP:0004315)3.80567710
16Orchitis (HP:0100796)3.76276925
17Meningitis (HP:0001287)3.70748813
18Increased IgM level (HP:0003496)3.55903427
19Chronic mucocutaneous candidiasis (HP:0002728)3.52172856
20Recurrent cutaneous fungal infections (HP:0011370)3.52172856
21Recurrent fungal infections (HP:0002841)3.50660925
22Lymphopenia (HP:0001888)3.49429471
23Recurrent viral infections (HP:0004429)3.46898753
24Recurrent abscess formation (HP:0002722)3.44483473
25Gastrointestinal infarctions (HP:0005244)3.28116320
26Chronic obstructive pulmonary disease (HP:0006510)3.25867608
27Obstructive lung disease (HP:0006536)3.25867608
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.24344524
29Stomatitis (HP:0010280)3.17956881
30Abnormality of cells of the lymphoid lineage (HP:0012140)3.15826917
31Keratoconjunctivitis (HP:0001096)3.14573514
32Recurrent bacterial skin infections (HP:0005406)3.12916609
33Keratoconjunctivitis sicca (HP:0001097)3.11784698
34Combined immunodeficiency (HP:0005387)3.11511581
35Autoimmune hemolytic anemia (HP:0001890)3.08579067
36Pigmentary retinal degeneration (HP:0001146)2.97827386
37Pulmonary infiltrates (HP:0002113)2.97171392
38Mediastinal lymphadenopathy (HP:0100721)2.91685467
39Recurrent bronchitis (HP:0002837)2.88769133
40Vasculitis (HP:0002633)2.86194151
41Recurrent skin infections (HP:0001581)2.85689025
42Nasal polyposis (HP:0100582)2.83122611
43Hemiplegia (HP:0002301)2.71746424
44Leukocytosis (HP:0001974)2.70409602
45Chest pain (HP:0100749)2.68103164
46Abnormality of T cell physiology (HP:0011840)2.64191418
47Recurrent gram-negative bacterial infections (HP:0005420)2.61576518
48Recurrent otitis media (HP:0000403)2.61309820
49Acute hepatic failure (HP:0006554)2.61300523
50Panhypogammaglobulinemia (HP:0003139)2.58655111
51Abnormal albumin level (HP:0012116)2.58454980
52Hypoalbuminemia (HP:0003073)2.58454980
53Abnormality of the pleura (HP:0002103)2.56979204
54Severe visual impairment (HP:0001141)2.56596070
55Gangrene (HP:0100758)2.55355282
56Hypergammaglobulinemia (HP:0010702)2.54613264
57Abnormality of eosinophils (HP:0001879)2.53249924
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52358952
59Petechiae (HP:0000967)2.50913204
60Pustule (HP:0200039)2.50570247
61Hemoptysis (HP:0002105)2.40324297
62Pulmonary embolism (HP:0002204)2.39395185
63Abnormality of the prostate (HP:0008775)2.38224812
64Increased IgE level (HP:0003212)2.35964514
65Abnormality of B cell number (HP:0010975)2.33591387
66Bronchiectasis (HP:0002110)2.32786987
67Joint swelling (HP:0001386)2.31129442
68Abnormality of the nasal mucosa (HP:0000433)2.30396931
69Lymphoma (HP:0002665)2.29718086
70Abnormal rod and cone electroretinograms (HP:0008323)2.27302932
71B lymphocytopenia (HP:0010976)2.26487394
72Granulocytopenia (HP:0001913)2.25251814
73Purpura (HP:0000979)2.24019360
74Hypoplasia of the thymus (HP:0000778)2.23415324
75Inflammation of the large intestine (HP:0002037)2.23022902
76Autoimmune thrombocytopenia (HP:0001973)2.22866421
77Eosinophilia (HP:0001880)2.21736134
78Bronchitis (HP:0012387)2.21465995
79Attenuation of retinal blood vessels (HP:0007843)2.18743068
80IgM deficiency (HP:0002850)2.17584573
81Recurrent sinusitis (HP:0011108)2.14981600
82Gastrointestinal inflammation (HP:0004386)2.14538402
83Thyroiditis (HP:0100646)2.14032095
84Amyotrophic lateral sclerosis (HP:0007354)2.09695720
85Increased intramyocellular lipid droplets (HP:0012240)2.04079227
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02316312
87Slow saccadic eye movements (HP:0000514)1.94680020
88Pancytopenia (HP:0001876)1.94457637
89Increased CSF protein (HP:0002922)1.93372719
90Agammaglobulinemia (HP:0004432)1.93061448
91Tetany (HP:0001281)1.90601690
92Abnormal respiratory motile cilium morphology (HP:0005938)1.88520338
93Abnormal respiratory epithelium morphology (HP:0012253)1.88520338
94Anorexia (HP:0002039)1.87572852
95Abnormality of liposaccharide metabolism (HP:0010968)1.83798500
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.83798500
97Abnormality of glycolipid metabolism (HP:0010969)1.83798500
98Glomerulopathy (HP:0100820)1.83508405
99Arterial thrombosis (HP:0004420)1.81597174
100Neonatal respiratory distress (HP:0002643)1.81016030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.31375518
2TXK5.26113448
3TESK24.66797181
4MAP4K14.48892204
5BCKDK4.01911015
6TESK13.11394935
7ITK2.57803944
8SCYL22.31783988
9RIPK42.30804167
10CSK2.14629449
11GRK62.09365622
12BLK1.84573843
13ZAP701.79466106
14FES1.77828122
15LIMK11.77076391
16MAP3K111.73771461
17SYK1.71568142
18BTK1.69971993
19CSF1R1.59028306
20MAP3K121.56188166
21LCK1.52467768
22EPHB11.51612231
23TAOK31.48383725
24IRAK41.41508731
25JAK31.37305261
26STK161.35271687
27GRK71.33325339
28LYN1.23654827
29TBK11.23590490
30IKBKE1.23261704
31MAP3K31.20994177
32CDK191.18326543
33TYK21.12412739
34TAOK21.11739608
35MAP2K61.11255792
36MAPKAPK31.09059132
37PRKCQ1.04243894
38PIK3CG1.01559845
39PASK0.98654300
40STK100.98288102
41HCK0.96950108
42MAP2K30.96583545
43CLK10.96451824
44TNK20.94857631
45TAOK10.88782720
46PDK10.85952459
47JAK20.82856177
48FYN0.76811150
49WNK40.70859776
50MAPK110.70286129
51ERN10.70023548
52ADRBK20.69009261
53TEC0.68250381
54PRPF4B0.68222419
55IKBKB0.63994444
56CAMKK10.59985747
57CAMKK20.57989919
58DAPK10.51276331
59MAP3K10.50761333
60JAK10.49688766
61MOS0.49074484
62KIT0.46037571
63FGR0.45652629
64DYRK1B0.42894744
65MAPKAPK20.41971148
66CDK40.39048913
67BMPR20.37780947
68MARK30.36751817
69INSR0.36119325
70EPHA30.31630585
71PIM10.31117961
72FGFR40.29640489
73ROCK10.29367650
74PAK10.28111476
75INSRR0.27920870
76LMTK20.27345804
77MAPK150.27092317
78TGFBR20.27001745
79IGF1R0.26201221
80ADRBK10.25463659
81MAP3K50.25238729
82IRAK10.25071716
83DDR20.24848368
84MAP4K20.24564903
85PDPK10.22815591
86PRKCH0.22799171
87EGFR0.21782875
88NEK90.21432447
89PTK60.20781359
90NEK60.20173548
91CSNK1G30.20094229
92ERBB30.17714153
93SIK30.17347008
94HIPK20.16759736
95MATK0.16664585
96MYLK0.15434833
97RPS6KA50.15282891
98SRC0.14913072
99LRRK20.14809896
100GRK10.14799546

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.68648985
2Graft-versus-host disease_Homo sapiens_hsa053324.22687834
3Autoimmune thyroid disease_Homo sapiens_hsa053204.18516758
4Allograft rejection_Homo sapiens_hsa053304.11316434
5Antigen processing and presentation_Homo sapiens_hsa046123.99941706
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.24604743
7Type I diabetes mellitus_Homo sapiens_hsa049403.23709676
8Hematopoietic cell lineage_Homo sapiens_hsa046402.97028464
9T cell receptor signaling pathway_Homo sapiens_hsa046602.76101661
10Viral myocarditis_Homo sapiens_hsa054162.63481087
11Proteasome_Homo sapiens_hsa030502.10558583
12Measles_Homo sapiens_hsa051622.03164794
13Staphylococcus aureus infection_Homo sapiens_hsa051501.86125765
14Leishmaniasis_Homo sapiens_hsa051401.79262884
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77761555
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75706476
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74799235
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.71302450
19Shigellosis_Homo sapiens_hsa051311.67996578
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.60848933
21Rheumatoid arthritis_Homo sapiens_hsa053231.57389954
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50344859
23Asthma_Homo sapiens_hsa053101.49845305
24Malaria_Homo sapiens_hsa051441.44144166
25Herpes simplex infection_Homo sapiens_hsa051681.39867638
26Salmonella infection_Homo sapiens_hsa051321.38437784
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35982310
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32784546
29Osteoclast differentiation_Homo sapiens_hsa043801.22708842
30Legionellosis_Homo sapiens_hsa051341.18162704
31Influenza A_Homo sapiens_hsa051641.16797154
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14993164
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13509765
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07038685
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06853673
36Tuberculosis_Homo sapiens_hsa051521.05764070
37Chemokine signaling pathway_Homo sapiens_hsa040620.96877019
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.95064088
39Oxidative phosphorylation_Homo sapiens_hsa001900.92771200
40B cell receptor signaling pathway_Homo sapiens_hsa046620.86770025
41Epstein-Barr virus infection_Homo sapiens_hsa051690.82622990
42Phagosome_Homo sapiens_hsa041450.79398250
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78507771
44Pertussis_Homo sapiens_hsa051330.77871430
45Endocytosis_Homo sapiens_hsa041440.77370407
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77212256
47Toxoplasmosis_Homo sapiens_hsa051450.77094196
48Phototransduction_Homo sapiens_hsa047440.76884559
49Parkinsons disease_Homo sapiens_hsa050120.69761940
50Regulation of autophagy_Homo sapiens_hsa041400.68241923
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67405570
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66905206
53TNF signaling pathway_Homo sapiens_hsa046680.65987019
54Apoptosis_Homo sapiens_hsa042100.64130768
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61848808
56RNA polymerase_Homo sapiens_hsa030200.56889813
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.54683035
58African trypanosomiasis_Homo sapiens_hsa051430.53371579
59HTLV-I infection_Homo sapiens_hsa051660.52606315
60Alzheimers disease_Homo sapiens_hsa050100.49617504
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48680733
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44035708
63Prion diseases_Homo sapiens_hsa050200.43352048
64Huntingtons disease_Homo sapiens_hsa050160.41853823
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39048623
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37945453
67Pyrimidine metabolism_Homo sapiens_hsa002400.37031001
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36396814
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35671054
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35489136
71Olfactory transduction_Homo sapiens_hsa047400.33377201
72Hepatitis B_Homo sapiens_hsa051610.31466125
73Linoleic acid metabolism_Homo sapiens_hsa005910.31116390
74Viral carcinogenesis_Homo sapiens_hsa052030.29781087
75Lysosome_Homo sapiens_hsa041420.29699363
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29508320
77Platelet activation_Homo sapiens_hsa046110.28155505
78Acute myeloid leukemia_Homo sapiens_hsa052210.26737837
79Other glycan degradation_Homo sapiens_hsa005110.26421151
80Cardiac muscle contraction_Homo sapiens_hsa042600.22990276
81Fructose and mannose metabolism_Homo sapiens_hsa000510.22141364
82Systemic lupus erythematosus_Homo sapiens_hsa053220.20266774
83Non-small cell lung cancer_Homo sapiens_hsa052230.17916256
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.16239998
85Nitrogen metabolism_Homo sapiens_hsa009100.13324956
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.12853877
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.12813758
88Purine metabolism_Homo sapiens_hsa002300.12495132
89VEGF signaling pathway_Homo sapiens_hsa043700.12466695
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.09709790
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06716219
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06691787
93Peroxisome_Homo sapiens_hsa041460.05897831
94ABC transporters_Homo sapiens_hsa020100.05295972
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05287039
96Hepatitis C_Homo sapiens_hsa051600.04993927
97MAPK signaling pathway_Homo sapiens_hsa040100.03832452
98Arachidonic acid metabolism_Homo sapiens_hsa005900.03195158
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01708245
100Protein export_Homo sapiens_hsa03060-0.0131926

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