HCG4P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.46743789
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31096609
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23397161
4positive regulation of gamma-delta T cell activation (GO:0046645)5.01831610
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.96631975
6negative regulation of cell killing (GO:0031342)4.96631975
7immunoglobulin mediated immune response (GO:0016064)4.94244107
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93350740
9leukocyte aggregation (GO:0070486)4.65049600
10detection of bacterium (GO:0016045)4.42664624
11cellular response to type I interferon (GO:0071357)4.39656716
12type I interferon signaling pathway (GO:0060337)4.39656716
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.37778634
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.37778634
15modulation by symbiont of host immune response (GO:0052553)4.37778634
16positive regulation by symbiont of host defense response (GO:0052509)4.37778634
17modulation by symbiont of host defense response (GO:0052031)4.37778634
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.37778634
19response to type I interferon (GO:0034340)4.34962163
20regulation of B cell receptor signaling pathway (GO:0050855)4.30728922
21detection of other organism (GO:0098543)4.28919433
22T cell migration (GO:0072678)4.08634812
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02413309
24B cell mediated immunity (GO:0019724)3.99644699
25T-helper 1 type immune response (GO:0042088)3.90845707
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.75032762
27interferon-gamma-mediated signaling pathway (GO:0060333)3.74736088
28response to peptidoglycan (GO:0032494)3.74324431
29negative thymic T cell selection (GO:0045060)3.74213083
30NIK/NF-kappaB signaling (GO:0038061)3.74208929
31negative regulation of interleukin-12 production (GO:0032695)3.72079996
32positive thymic T cell selection (GO:0045059)3.64393512
33positive regulation of B cell differentiation (GO:0045579)3.62096120
34negative T cell selection (GO:0043383)3.59089837
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57681968
36defense response to protozoan (GO:0042832)3.56033785
37neutrophil activation involved in immune response (GO:0002283)3.54386754
38B cell receptor signaling pathway (GO:0050853)3.54215709
39regulation of T cell mediated cytotoxicity (GO:0001914)3.52805010
40response to interleukin-15 (GO:0070672)3.51506256
41response to muramyl dipeptide (GO:0032495)3.51466976
42regulation of gamma-delta T cell activation (GO:0046643)3.48539258
43response to protozoan (GO:0001562)3.48001189
44regulation of alpha-beta T cell proliferation (GO:0046640)3.39502547
45cellular response to interleukin-15 (GO:0071350)3.39474995
46myeloid dendritic cell differentiation (GO:0043011)3.37210846
47macrophage activation involved in immune response (GO:0002281)3.36113105
48myeloid dendritic cell activation (GO:0001773)3.35176241
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34851689
50response to host immune response (GO:0052572)3.32888433
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32888433
52regulation of antigen processing and presentation (GO:0002577)3.27020629
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.26881814
54detection of external biotic stimulus (GO:0098581)3.26555725
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24308744
56regulation of interferon-beta biosynthetic process (GO:0045357)3.21633394
57regulation of B cell differentiation (GO:0045577)3.17710030
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15940693
59negative regulation of myeloid cell apoptotic process (GO:0033033)3.15273739
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13691021
61negative regulation of T cell mediated immunity (GO:0002710)3.10904158
62positive regulation of interferon-alpha production (GO:0032727)3.09914665
63negative regulation of leukocyte mediated immunity (GO:0002704)3.09817278
64regulation of interferon-alpha production (GO:0032647)3.09688297
65negative regulation of innate immune response (GO:0045824)3.09682574
66microglial cell activation (GO:0001774)3.06048678
67response to host defenses (GO:0052200)3.03715068
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03715068
69response to host (GO:0075136)3.03715068
70positive regulation of antigen processing and presentation (GO:0002579)3.02871187
71thymic T cell selection (GO:0045061)2.98426025
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98378445
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96234752
74respiratory burst (GO:0045730)2.95678152
75regulation of gamma-delta T cell differentiation (GO:0045586)2.95083856
76regulation of natural killer cell mediated immunity (GO:0002715)2.91070189
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91070189
78negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.90753889
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90546889
80response to interferon-beta (GO:0035456)2.90389024
81negative regulation of cytokine production involved in immune response (GO:0002719)2.89286833
82germinal center formation (GO:0002467)2.88526547
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88001329
84mature B cell differentiation involved in immune response (GO:0002313)2.87642279
85detection of biotic stimulus (GO:0009595)2.87229942
86positive regulation of immunoglobulin mediated immune response (GO:0002891)2.87106167
87positive regulation of B cell mediated immunity (GO:0002714)2.87106167
88positive T cell selection (GO:0043368)2.86635827
89cellular response to interferon-gamma (GO:0071346)2.85592299
90cellular extravasation (GO:0045123)2.84330476
91negative regulation of erythrocyte differentiation (GO:0045647)2.83032829
92negative regulation of B cell apoptotic process (GO:0002903)2.82890794
93tolerance induction (GO:0002507)2.82597667
94positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.81745598
95regulation of B cell apoptotic process (GO:0002902)2.79745866
96myeloid cell activation involved in immune response (GO:0002275)2.79165086
97positive regulation of T cell mediated immunity (GO:0002711)2.79077770
98positive regulation of isotype switching (GO:0045830)2.78692568
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78308333
100positive regulation of interleukin-17 production (GO:0032740)2.77728787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85380398
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.12972125
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.36141324
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.19855598
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12254852
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07669025
7VDR_21846776_ChIP-Seq_THP-1_Human2.98381233
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95123907
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93062615
10MYC_22102868_ChIP-Seq_BL_Human2.69549291
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60734548
12MAF_26560356_Chip-Seq_TH1_Human2.52707384
13VDR_24763502_ChIP-Seq_THP-1_Human2.44734719
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41022671
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38563528
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27751854
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24642202
18SCL_19346495_ChIP-Seq_HPC-7_Human2.24276309
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23660465
20UTX_26944678_Chip-Seq_JUKART_Human2.21533226
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19988169
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18262436
23MYB_26560356_Chip-Seq_TH2_Human2.17331946
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.16269831
25SPI1_23547873_ChIP-Seq_NB4_Human2.15130721
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11428896
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99510623
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98956966
29RUNX_20019798_ChIP-Seq_JUKART_Human1.94264096
30MYB_26560356_Chip-Seq_TH1_Human1.93415915
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.90849125
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88085629
33MAF_26560356_Chip-Seq_TH2_Human1.87264726
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85172286
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81997176
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80136238
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75007859
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74198689
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71168839
40LXR_22292898_ChIP-Seq_THP-1_Human1.69681336
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68139398
42SPI1_23127762_ChIP-Seq_K562_Human1.67849843
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64198604
44TCF7_22412390_ChIP-Seq_EML_Mouse1.63747122
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63023573
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54768283
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53972681
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.52200080
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51143261
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50302431
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49295550
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.46306533
53BCL6_27268052_Chip-Seq_Bcells_Human1.45789710
54KDM2B_26808549_Chip-Seq_DND41_Human1.45719036
55GATA3_27048872_Chip-Seq_THYMUS_Human1.45435905
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.39292707
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37585643
58BCOR_27268052_Chip-Seq_Bcells_Human1.35061040
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34447866
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32549946
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31934119
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30735925
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30006213
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28381050
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24494851
66CIITA_25753668_ChIP-Seq_RAJI_Human1.23387179
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22943591
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22777718
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22121944
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.22108991
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21586999
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18853780
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18308070
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17053217
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15771853
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13374134
77P68_20966046_ChIP-Seq_HELA_Human1.08755555
78SPI1_20517297_ChIP-Seq_HL60_Human1.08513566
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08120459
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07487745
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07436191
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06753020
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06700758
84GATA1_19941826_ChIP-Seq_K562_Human1.06117360
85NCOR1_26117541_ChIP-Seq_K562_Human1.03580379
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02476167
87GATA3_26560356_Chip-Seq_TH2_Human1.01552145
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00349256
89P300_27268052_Chip-Seq_Bcells_Human0.99637472
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.99541568
91VDR_24787735_ChIP-Seq_THP-1_Human0.97991502
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97882974
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97026993
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.95837470
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95640513
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94828492
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.94766703
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94194512
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92898885
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92485612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97526643
2MP0003724_increased_susceptibility_to3.84352074
3MP0003436_decreased_susceptibility_to3.82879683
4MP0005671_abnormal_response_to3.73315625
5MP0000685_abnormal_immune_system3.72423449
6MP0003303_peritoneal_inflammation3.51205778
7MP0001800_abnormal_humoral_immune3.20479536
8MP0005000_abnormal_immune_tolerance3.19395572
9MP0005387_immune_system_phenotype3.19111511
10MP0001790_abnormal_immune_system3.19111511
11MP0009785_altered_susceptibility_to2.93801085
12MP0005025_abnormal_response_to2.86562480
13MP0002148_abnormal_hypersensitivity_rea2.76757201
14MP0002723_abnormal_immune_serum2.76095888
15MP0003763_abnormal_thymus_physiology2.69197410
16MP0002452_abnormal_antigen_presenting2.67136289
17MP0002419_abnormal_innate_immunity2.63422028
18MP0002420_abnormal_adaptive_immunity2.56712801
19MP0001819_abnormal_immune_cell2.53586906
20MP0009333_abnormal_splenocyte_physiolog2.19234264
21MP0005464_abnormal_platelet_physiology2.17005336
22MP0006082_CNS_inflammation2.13091176
23MP0002398_abnormal_bone_marrow2.11032232
24MP0003300_gastrointestinal_ulcer2.07962868
25MP0000716_abnormal_immune_system2.02893616
26MP0010155_abnormal_intestine_physiology2.02565665
27MP0002405_respiratory_system_inflammati1.97246220
28MP0008260_abnormal_autophagy1.95132487
29MP0009278_abnormal_bone_marrow1.93396476
30MP0001533_abnormal_skeleton_physiology1.92944259
31MP0004947_skin_inflammation1.86759877
32MP0001845_abnormal_inflammatory_respons1.82863382
33MP0000689_abnormal_spleen_morphology1.74793848
34MP0000465_gastrointestinal_hemorrhage1.73143883
35MP0001853_heart_inflammation1.72124425
36MP0005058_abnormal_lysosome_morphology1.68291712
37MP0002429_abnormal_blood_cell1.66502083
38MP0002722_abnormal_immune_system1.65977466
39MP0001545_abnormal_hematopoietic_system1.61740691
40MP0005397_hematopoietic_system_phenotyp1.61740691
41MP0003183_abnormal_peptide_metabolism1.56423166
42MP0002933_joint_inflammation1.54592262
43MP0008469_abnormal_protein_level1.54488256
44MP0003191_abnormal_cellular_cholesterol1.51437127
45MP0002138_abnormal_hepatobiliary_system1.51396107
46MP0004510_myositis1.45378767
47MP0005645_abnormal_hypothalamus_physiol1.45249639
48MP0005451_abnormal_body_composition1.42275652
49MP0002166_altered_tumor_susceptibility1.40737732
50MP0009840_abnormal_foam_cell1.40234837
51MP0009764_decreased_sensitivity_to1.38809701
52MP0005310_abnormal_salivary_gland1.38682357
53MP0000703_abnormal_thymus_morphology1.38615098
54MP0002396_abnormal_hematopoietic_system1.33122460
55MP0001873_stomach_inflammation1.31767264
56MP0003806_abnormal_nucleotide_metabolis1.29022122
57MP0003866_abnormal_defecation1.27971599
58MP0000858_altered_metastatic_potential1.23211387
59MP0003172_abnormal_lysosome_physiology1.19664606
60MP0002132_abnormal_respiratory_system1.18963525
61MP0001851_eye_inflammation1.15424411
62MP0003075_altered_response_to1.12704880
63MP0000604_amyloidosis1.05804737
64MP0009763_increased_sensitivity_to1.03863944
65MP0002006_tumorigenesis1.01238694
66MP0002998_abnormal_bone_remodeling1.00098674
67MP0000343_altered_response_to0.98473381
68MP0002254_reproductive_system_inflammat0.96669513
69MP0004883_abnormal_blood_vessel0.91656399
70MP0005390_skeleton_phenotype0.90324897
71MP0008004_abnormal_stomach_pH0.90073501
72MP0003448_altered_tumor_morphology0.89208678
73MP0005166_decreased_susceptibility_to0.87224515
74MP0004808_abnormal_hematopoietic_stem0.86883401
75MP0003828_pulmonary_edema0.86557342
76MP0000490_abnormal_crypts_of0.79251787
77MP0009765_abnormal_xenobiotic_induced0.78404562
78MP0000249_abnormal_blood_vessel0.78122585
79MP0002019_abnormal_tumor_incidence0.77502583
80MP0005164_abnormal_response_to0.76463353
81MP0001663_abnormal_digestive_system0.75637848
82MP0001348_abnormal_lacrimal_gland0.67622420
83MP0005075_abnormal_melanosome_morpholog0.64207562
84MP0003045_fibrosis0.60225071
85MP0008874_decreased_physiological_sensi0.60106257
86MP0005319_abnormal_enzyme/_coenzyme0.59195662
87MP0003795_abnormal_bone_structure0.58963395
88MP0000609_abnormal_liver_physiology0.57255807
89MP0004381_abnormal_hair_follicle0.54539423
90MP0002277_abnormal_respiratory_mucosa0.51356010
91MP0003329_amyloid_beta_deposits0.50653102
92MP0005535_abnormal_body_temperature0.50457661
93MP0002693_abnormal_pancreas_physiology0.49763614
94MP0003453_abnormal_keratinocyte_physiol0.49688552
95MP0005167_abnormal_blood-brain_barrier0.47333542
96MP0009643_abnormal_urine_homeostasis0.47263470
97MP0002139_abnormal_hepatobiliary_system0.46851580
98MP0001727_abnormal_embryo_implantation0.46635788
99MP0005165_increased_susceptibility_to0.46239520
100MP0002136_abnormal_kidney_physiology0.44574849

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.48376721
2Abnormality of macrophages (HP:0004311)4.89710635
3Myositis (HP:0100614)4.59158971
4Recurrent bacterial skin infections (HP:0005406)4.55804103
5Mediastinal lymphadenopathy (HP:0100721)4.52792486
6Elevated erythrocyte sedimentation rate (HP:0003565)4.43373191
7Agammaglobulinemia (HP:0004432)4.42638240
8Meningitis (HP:0001287)4.41893778
9Recurrent abscess formation (HP:0002722)4.40925834
10Orchitis (HP:0100796)4.25866308
11Retrobulbar optic neuritis (HP:0100654)4.15860408
12Optic neuritis (HP:0100653)4.15860408
13Vasculitis (HP:0002633)3.97348573
14Gastrointestinal stroma tumor (HP:0100723)3.91385618
15Recurrent fungal infections (HP:0002841)3.90427675
16Cellulitis (HP:0100658)3.75119396
17Stomatitis (HP:0010280)3.74923437
18Recurrent gram-negative bacterial infections (HP:0005420)3.74275864
19Chronic obstructive pulmonary disease (HP:0006510)3.73432204
20Obstructive lung disease (HP:0006536)3.73432204
21Increased IgE level (HP:0003212)3.64689395
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.61888103
23Recurrent viral infections (HP:0004429)3.61823642
24Urticaria (HP:0001025)3.57579274
25Petechiae (HP:0000967)3.42405623
26Panhypogammaglobulinemia (HP:0003139)3.39792989
27Recurrent skin infections (HP:0001581)3.37547670
28Recurrent bronchitis (HP:0002837)3.35452304
29Recurrent cutaneous fungal infections (HP:0011370)3.33116213
30Chronic mucocutaneous candidiasis (HP:0002728)3.33116213
31IgM deficiency (HP:0002850)3.30501253
32Encephalitis (HP:0002383)3.30074542
33Gastrointestinal infarctions (HP:0005244)3.28732259
34Inflammation of the large intestine (HP:0002037)3.26622547
35Gastrointestinal inflammation (HP:0004386)3.24075932
36Recurrent sinusitis (HP:0011108)3.22793691
37Increased IgM level (HP:0003496)3.11923817
38Pulmonary infiltrates (HP:0002113)3.11393425
39Colitis (HP:0002583)3.11246283
40Prolonged bleeding time (HP:0003010)3.01722917
41Lymphopenia (HP:0001888)3.00661581
42Keratoconjunctivitis sicca (HP:0001097)2.95324355
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.95222049
44Purpura (HP:0000979)2.84772944
45Hypertensive crisis (HP:0100735)2.81203205
46Abnormality of T cell physiology (HP:0011840)2.78254895
47Abnormality of T cells (HP:0002843)2.77906415
48Spontaneous hematomas (HP:0007420)2.77301175
49IgG deficiency (HP:0004315)2.76886546
50Keratoconjunctivitis (HP:0001096)2.72776832
51Hypergammaglobulinemia (HP:0010702)2.72445222
52Autoimmune hemolytic anemia (HP:0001890)2.67212666
53Epistaxis (HP:0000421)2.67184841
54Skin rash (HP:0000988)2.67119248
55Hemoptysis (HP:0002105)2.66217872
56Chest pain (HP:0100749)2.64438018
57Granulocytopenia (HP:0001913)2.62467726
58Emphysema (HP:0002097)2.61911344
59Recurrent pneumonia (HP:0006532)2.59495199
60Osteomyelitis (HP:0002754)2.59306001
61IgA deficiency (HP:0002720)2.55654024
62Systemic lupus erythematosus (HP:0002725)2.54070249
63Pustule (HP:0200039)2.53928690
64Papilloma (HP:0012740)2.53664662
65Verrucae (HP:0200043)2.53664662
66Sepsis (HP:0100806)2.53654259
67Abnormality of B cell number (HP:0010975)2.53128392
68Leukocytosis (HP:0001974)2.53098561
69Recurrent lower respiratory tract infections (HP:0002783)2.49308241
70T lymphocytopenia (HP:0005403)2.48391174
71Abnormality of liposaccharide metabolism (HP:0010968)2.46984429
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.46984429
73Abnormality of glycolipid metabolism (HP:0010969)2.46984429
74B lymphocytopenia (HP:0010976)2.46111555
75Chronic diarrhea (HP:0002028)2.45732751
76Abnormality of T cell number (HP:0011839)2.45699843
77Abnormality of the prostate (HP:0008775)2.42277404
78Abnormality of the pleura (HP:0002103)2.40819140
79Autoimmune thrombocytopenia (HP:0001973)2.40167393
80Chronic otitis media (HP:0000389)2.38511276
81Gingivitis (HP:0000230)2.37571379
82Gangrene (HP:0100758)2.37348386
83Arterial thrombosis (HP:0004420)2.35185593
84Hepatosplenomegaly (HP:0001433)2.31359702
85Restrictive lung disease (HP:0002091)2.31225326
86Premature loss of primary teeth (HP:0006323)2.28993920
87Arthralgia (HP:0002829)2.27423312
88Gingival bleeding (HP:0000225)2.26448886
89Pulmonary embolism (HP:0002204)2.26113405
90Anorexia (HP:0002039)2.20862241
91Skin ulcer (HP:0200042)2.19503595
92Dysostosis multiplex (HP:0000943)2.19001452
93Joint swelling (HP:0001386)2.18431122
94Eosinophilia (HP:0001880)2.17181282
95Severe combined immunodeficiency (HP:0004430)2.14859962
96Prostate neoplasm (HP:0100787)2.11673938
97Increased serum ferritin (HP:0003281)2.06239873
98Acute hepatic failure (HP:0006554)2.03954360
99Loss of speech (HP:0002371)2.00644053
100Episodic fever (HP:0001954)1.95346038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.22905141
2ERN13.20360961
3RIPK43.16015101
4IRAK42.85183173
5TBK12.66625609
6PRPF4B2.61534992
7MAP3K142.41557756
8IKBKE2.37474039
9TYK22.37242943
10BLK2.26862599
11TESK22.11253138
12MAP2K32.08140086
13MAP3K112.06838148
14TAOK32.01270964
15JAK31.89373631
16IKBKB1.84764300
17BCKDK1.84644296
18SYK1.84170136
19GRK61.79226522
20TNK21.79073640
21BTK1.75464387
22FES1.73724035
23TLK11.71618691
24TXK1.66620356
25KIT1.66285072
26SMG11.62591529
27CSK1.61198130
28VRK11.57507835
29MAP3K31.56772111
30TAOK21.43343976
31ZAP701.40669072
32PIM21.39688452
33CSF1R1.36256142
34LYN1.34070115
35JAK11.34064378
36KDR1.30252441
37MAP3K131.27531719
38FGFR41.25856480
39HCK1.24478598
40NME21.23772543
41DAPK31.19744441
42LCK1.19015067
43MAP3K11.14848475
44ARAF1.11724655
45IRAK31.11570557
46ITK1.11181548
47TAOK11.10433082
48EPHB11.06604868
49FGR1.05654394
50RPS6KA51.03978325
51PIM10.97335946
52JAK20.95304544
53MARK30.93372122
54MATK0.92633996
55SIK30.89599220
56BMPR20.87925098
57ZAK0.85711264
58SIK20.84095118
59TEC0.82863244
60SIK10.82141137
61HIPK20.81419022
62PRKCQ0.80643691
63VRK20.78254171
64STK100.74224267
65EPHA30.71058276
66MAPK120.67267208
67IRAK10.63794799
68CHUK0.62960710
69MAPK110.62189400
70MAPK70.60093088
71MAPKAPK30.57936008
72PDK10.56169237
73FGFR30.55281359
74CDC42BPA0.55181721
75LRRK20.53234462
76STK40.51848398
77MAP2K20.50310244
78TRIB30.49764726
79GRK70.49645071
80PRKD20.46817990
81CDK120.45501986
82PIK3CG0.42559228
83CDK90.42527469
84AURKA0.42025887
85TESK10.41894758
86MAPKAPK20.41804469
87CDK40.41585025
88NEK90.40620440
89MOS0.40444282
90TGFBR20.38919510
91PRKCD0.38673293
92PTK2B0.37085503
93FYN0.35321472
94MARK20.34312792
95DYRK1B0.34306856
96RPS6KC10.33762558
97RPS6KL10.33762558
98PDPK10.33109183
99IRAK20.32213564
100PKN10.31770404

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.01705804
2Systemic lupus erythematosus_Homo sapiens_hsa053223.77574321
3Autoimmune thyroid disease_Homo sapiens_hsa053203.61544805
4Primary immunodeficiency_Homo sapiens_hsa053403.57107520
5Graft-versus-host disease_Homo sapiens_hsa053323.48869766
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.39857962
7Asthma_Homo sapiens_hsa053103.17188709
8Type I diabetes mellitus_Homo sapiens_hsa049402.92325187
9Leishmaniasis_Homo sapiens_hsa051402.88328533
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60488889
11Staphylococcus aureus infection_Homo sapiens_hsa051502.60150745
12Antigen processing and presentation_Homo sapiens_hsa046122.31586718
13Viral myocarditis_Homo sapiens_hsa054162.16114609
14Osteoclast differentiation_Homo sapiens_hsa043802.07507629
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.06380073
16B cell receptor signaling pathway_Homo sapiens_hsa046622.00661581
17Alcoholism_Homo sapiens_hsa050341.82624611
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81679881
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79041271
20Hematopoietic cell lineage_Homo sapiens_hsa046401.78776160
21Herpes simplex infection_Homo sapiens_hsa051681.75946335
22Tuberculosis_Homo sapiens_hsa051521.69200652
23Rheumatoid arthritis_Homo sapiens_hsa053231.66494857
24Measles_Homo sapiens_hsa051621.63770225
25Other glycan degradation_Homo sapiens_hsa005111.62804898
26Influenza A_Homo sapiens_hsa051641.57151181
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54597325
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50169773
29Toxoplasmosis_Homo sapiens_hsa051451.49383674
30Malaria_Homo sapiens_hsa051441.40936597
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34575630
32Viral carcinogenesis_Homo sapiens_hsa052031.32400262
33Acute myeloid leukemia_Homo sapiens_hsa052211.21589166
34T cell receptor signaling pathway_Homo sapiens_hsa046601.19122449
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18784187
36TNF signaling pathway_Homo sapiens_hsa046681.17625801
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14409812
38Phagosome_Homo sapiens_hsa041451.11613680
39Epstein-Barr virus infection_Homo sapiens_hsa051691.11540627
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.11196467
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03406683
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03107844
43Chemokine signaling pathway_Homo sapiens_hsa040620.99432275
44Pertussis_Homo sapiens_hsa051330.95085587
45Legionellosis_Homo sapiens_hsa051340.93036958
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91841164
47Apoptosis_Homo sapiens_hsa042100.91802384
48Hepatitis B_Homo sapiens_hsa051610.91041279
49African trypanosomiasis_Homo sapiens_hsa051430.90997100
50Shigellosis_Homo sapiens_hsa051310.86360118
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83527248
52Hepatitis C_Homo sapiens_hsa051600.76362447
53Lysosome_Homo sapiens_hsa041420.74643796
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74300440
55HTLV-I infection_Homo sapiens_hsa051660.73733675
56Platelet activation_Homo sapiens_hsa046110.67734970
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.64872076
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63018314
59Salmonella infection_Homo sapiens_hsa051320.62199570
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.54039014
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45811005
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.43748737
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42391041
64Pentose phosphate pathway_Homo sapiens_hsa000300.39970433
65Pancreatic cancer_Homo sapiens_hsa052120.39582850
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39309133
67Non-small cell lung cancer_Homo sapiens_hsa052230.37861528
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35203309
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33269254
70Fructose and mannose metabolism_Homo sapiens_hsa000510.31151979
71VEGF signaling pathway_Homo sapiens_hsa043700.30630962
72Endocytosis_Homo sapiens_hsa041440.30058511
73Galactose metabolism_Homo sapiens_hsa000520.29172091
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27718394
75Chronic myeloid leukemia_Homo sapiens_hsa052200.26743343
76Prolactin signaling pathway_Homo sapiens_hsa049170.25306301
77Regulation of autophagy_Homo sapiens_hsa041400.25218017
78Arachidonic acid metabolism_Homo sapiens_hsa005900.21490848
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21138408
80HIF-1 signaling pathway_Homo sapiens_hsa040660.20329241
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.18525273
82Amoebiasis_Homo sapiens_hsa051460.18486174
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.16929166
84Ribosome_Homo sapiens_hsa030100.15393058
85Sulfur relay system_Homo sapiens_hsa041220.14537011
86Complement and coagulation cascades_Homo sapiens_hsa046100.13334184
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12782727
88Prion diseases_Homo sapiens_hsa050200.12480544
89Collecting duct acid secretion_Homo sapiens_hsa049660.11383986
90Bladder cancer_Homo sapiens_hsa052190.11194262
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.07833867
92MAPK signaling pathway_Homo sapiens_hsa040100.06278698
93Insulin resistance_Homo sapiens_hsa049310.05176536
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.04884294
95FoxO signaling pathway_Homo sapiens_hsa040680.04281586
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03148295
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03004918
98Notch signaling pathway_Homo sapiens_hsa043300.02512782
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.02392918
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01405248

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