HCG4P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.84010053
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20067190
3cytidine metabolic process (GO:0046087)5.16267201
4cytidine catabolic process (GO:0006216)5.16267201
5cytidine deamination (GO:0009972)5.16267201
6antigen processing and presentation of endogenous antigen (GO:0019883)5.05667107
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.95496443
8immunoglobulin mediated immune response (GO:0016064)4.75069485
9T cell migration (GO:0072678)4.66934913
10regulation of gamma-delta T cell differentiation (GO:0045586)4.66814561
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.66781458
12negative regulation of cell killing (GO:0031342)4.49512188
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49512188
14regulation of B cell receptor signaling pathway (GO:0050855)4.48277499
15regulation of gamma-delta T cell activation (GO:0046643)4.47940914
16positive regulation of B cell differentiation (GO:0045579)4.42714211
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42430271
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28337837
19negative T cell selection (GO:0043383)4.28066364
20positive thymic T cell selection (GO:0045059)4.22020832
21negative thymic T cell selection (GO:0045060)4.12564919
22cellular response to interleukin-15 (GO:0071350)4.11546409
23NIK/NF-kappaB signaling (GO:0038061)4.07925212
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.05554963
25regulation of B cell differentiation (GO:0045577)4.01693219
26DNA deamination (GO:0045006)3.90034203
27thymic T cell selection (GO:0045061)3.87719834
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84640270
29B cell mediated immunity (GO:0019724)3.83553393
30response to interleukin-15 (GO:0070672)3.75270553
31type I interferon signaling pathway (GO:0060337)3.69225905
32cellular response to type I interferon (GO:0071357)3.69225905
33response to type I interferon (GO:0034340)3.67845421
34positive T cell selection (GO:0043368)3.67504971
35T cell selection (GO:0045058)3.65465299
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.59927766
37B cell receptor signaling pathway (GO:0050853)3.57491921
38regulation of interferon-beta biosynthetic process (GO:0045357)3.47965263
39antigen processing and presentation via MHC class Ib (GO:0002475)3.43474671
40lymphocyte chemotaxis (GO:0048247)3.41696295
41regulation of T cell tolerance induction (GO:0002664)3.36810747
42interferon-gamma-mediated signaling pathway (GO:0060333)3.36381925
43regulation of T-helper 1 cell differentiation (GO:0045625)3.36095701
44positive regulation by symbiont of host defense response (GO:0052509)3.31974265
45modulation by symbiont of host defense response (GO:0052031)3.31974265
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31974265
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31974265
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.31974265
49modulation by symbiont of host immune response (GO:0052553)3.31974265
50tolerance induction (GO:0002507)3.31564836
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.30016432
52regulation of natural killer cell mediated immunity (GO:0002715)3.30016432
53T cell costimulation (GO:0031295)3.28904646
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.28611617
55negative regulation of viral genome replication (GO:0045071)3.27907615
56lymphocyte costimulation (GO:0031294)3.24090667
57positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.23632908
58detection of bacterium (GO:0016045)3.23017809
59regulation of T cell mediated cytotoxicity (GO:0001914)3.21810997
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20945905
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19153968
62lymphocyte migration (GO:0072676)3.17590063
63detection of other organism (GO:0098543)3.12742506
64negative regulation of type 2 immune response (GO:0002829)3.11441757
65regulation of tolerance induction (GO:0002643)3.11201151
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.09773098
67regulation of regulatory T cell differentiation (GO:0045589)3.05920379
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03320525
69regulation of alpha-beta T cell proliferation (GO:0046640)3.01351814
70antigen receptor-mediated signaling pathway (GO:0050851)3.01261584
71regulation of leukocyte mediated cytotoxicity (GO:0001910)3.01095364
72positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98373529
73positive regulation of defense response to virus by host (GO:0002230)2.97370522
74macrophage activation involved in immune response (GO:0002281)2.97199592
75positive regulation of tolerance induction (GO:0002645)2.96135611
76actin nucleation (GO:0045010)2.95913777
77regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95868953
78positive regulation of natural killer cell mediated immunity (GO:0002717)2.95838373
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.94727864
80negative regulation of innate immune response (GO:0045824)2.94409688
81interferon-gamma production (GO:0032609)2.93010174
82granulocyte activation (GO:0036230)2.88136038
83positive regulation of interleukin-2 production (GO:0032743)2.88099389
84T cell receptor signaling pathway (GO:0050852)2.86770362
85positive regulation of interferon-alpha production (GO:0032727)2.86727523
86negative regulation of T cell apoptotic process (GO:0070233)2.86369960
87regulation of interferon-alpha production (GO:0032647)2.85329370
88dendritic cell chemotaxis (GO:0002407)2.84460966
89neutrophil activation (GO:0042119)2.84370716
90regulation of antigen processing and presentation (GO:0002577)2.84184699
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.83137624
92regulation of germinal center formation (GO:0002634)2.82470086
93regulation of T cell receptor signaling pathway (GO:0050856)2.80977635
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80780906
95mast cell activation (GO:0045576)2.79921975
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.78620321
97positive regulation of B cell activation (GO:0050871)2.77314170
98negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.77141291
99regulation of cell killing (GO:0031341)2.76815586
100pyrimidine nucleoside catabolic process (GO:0046135)2.76519800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.93566575
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.54150528
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.14410188
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10136921
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71472000
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.47539387
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20868476
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87690117
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73505011
10MYB_26560356_Chip-Seq_TH2_Human2.70803096
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68204534
12RUNX_20019798_ChIP-Seq_JUKART_Human2.54177274
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52742108
14MYC_22102868_ChIP-Seq_BL_Human2.46613704
15MAF_26560356_Chip-Seq_TH1_Human2.42516648
16VDR_21846776_ChIP-Seq_THP-1_Human2.36131091
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34869545
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32289375
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.30359139
20MYB_26560356_Chip-Seq_TH1_Human2.23934790
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20755825
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19871228
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18868026
24UTX_26944678_Chip-Seq_JUKART_Human2.18054118
25VDR_24763502_ChIP-Seq_THP-1_Human2.17339793
26SCL_19346495_ChIP-Seq_HPC-7_Human2.08001236
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06375530
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05303505
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02321561
30SPI1_23547873_ChIP-Seq_NB4_Human1.97679558
31MAF_26560356_Chip-Seq_TH2_Human1.89461872
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88634335
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.83550071
34GATA3_27048872_Chip-Seq_THYMUS_Human1.80745275
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76493756
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71018518
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69844288
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67807351
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65886027
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62656826
41CIITA_25753668_ChIP-Seq_RAJI_Human1.62243790
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55304433
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54166202
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51114988
45SPI1_23127762_ChIP-Seq_K562_Human1.51033925
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50792123
47BCL6_27268052_Chip-Seq_Bcells_Human1.49730371
48GATA1_22025678_ChIP-Seq_K562_Human1.49229581
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47369926
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44831815
51GATA3_26560356_Chip-Seq_TH2_Human1.39551958
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.37843352
53LXR_22292898_ChIP-Seq_THP-1_Human1.37276081
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.29806009
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29797116
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.28214731
57TCF7_22412390_ChIP-Seq_EML_Mouse1.27520018
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27314290
59BCOR_27268052_Chip-Seq_Bcells_Human1.25140445
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23126438
61VDR_24787735_ChIP-Seq_THP-1_Human1.22290597
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.21477615
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20671857
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18725722
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18053454
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17179706
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.16148059
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15658328
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14695607
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14261193
71KDM2B_26808549_Chip-Seq_DND41_Human1.12724158
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11292204
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09021859
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08334390
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08334156
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08110657
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03036254
78P300_27268052_Chip-Seq_Bcells_Human1.02545526
79SPI1_20517297_ChIP-Seq_HL60_Human1.00040973
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99709148
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99190076
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97799890
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96684725
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95780358
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94454485
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94430966
87GATA1_19941826_ChIP-Seq_K562_Human0.91336991
88P68_20966046_ChIP-Seq_HELA_Human0.90661898
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.89333882
90EGR1_19374776_ChIP-ChIP_THP-1_Human0.88467044
91CTCF_26484167_Chip-Seq_Bcells_Mouse0.88181658
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.87805832
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87118168
94STAT1_20625510_ChIP-Seq_HELA_Human0.86214910
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85079228
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84661219
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81965428
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81503980
99PU_27001747_Chip-Seq_BMDM_Mouse0.80231351
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78938333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.98641323
2MP0001835_abnormal_antigen_presentation3.98947018
3MP0003436_decreased_susceptibility_to3.61125056
4MP0005000_abnormal_immune_tolerance3.35968197
5MP0009785_altered_susceptibility_to3.34627189
6MP0001800_abnormal_humoral_immune3.23168082
7MP0000685_abnormal_immune_system3.12702349
8MP0003763_abnormal_thymus_physiology3.11415280
9MP0005387_immune_system_phenotype3.01461665
10MP0001790_abnormal_immune_system3.01461665
11MP0005025_abnormal_response_to2.89248083
12MP0003724_increased_susceptibility_to2.88751002
13MP0002148_abnormal_hypersensitivity_rea2.87816897
14MP0002723_abnormal_immune_serum2.82468476
15MP0002138_abnormal_hepatobiliary_system2.72161227
16MP0002420_abnormal_adaptive_immunity2.65715060
17MP0002452_abnormal_antigen_presenting2.65322484
18MP0001819_abnormal_immune_cell2.61881409
19MP0003303_peritoneal_inflammation2.52023322
20MP0002419_abnormal_innate_immunity2.36899998
21MP0001873_stomach_inflammation2.27976738
22MP0010155_abnormal_intestine_physiology2.26368450
23MP0009333_abnormal_splenocyte_physiolog2.23714543
24MP0006082_CNS_inflammation2.22199708
25MP0002405_respiratory_system_inflammati2.11386281
26MP0002398_abnormal_bone_marrow2.08830132
27MP0000716_abnormal_immune_system2.07540941
28MP0004947_skin_inflammation2.00918185
29MP0003866_abnormal_defecation1.98515995
30MP0005464_abnormal_platelet_physiology1.95277657
31MP0001845_abnormal_inflammatory_respons1.92822237
32MP0000465_gastrointestinal_hemorrhage1.91364246
33MP0001533_abnormal_skeleton_physiology1.80601020
34MP0003300_gastrointestinal_ulcer1.77821256
35MP0000689_abnormal_spleen_morphology1.77221552
36MP0002722_abnormal_immune_system1.72267106
37MP0003045_fibrosis1.68988381
38MP0002429_abnormal_blood_cell1.64895260
39MP0002166_altered_tumor_susceptibility1.59375012
40MP0001853_heart_inflammation1.55816282
41MP0000703_abnormal_thymus_morphology1.54669216
42MP0008469_abnormal_protein_level1.52145156
43MP0005310_abnormal_salivary_gland1.49010861
44MP0003448_altered_tumor_morphology1.41633554
45MP0009840_abnormal_foam_cell1.32873912
46MP0002933_joint_inflammation1.31714930
47MP0009764_decreased_sensitivity_to1.25727948
48MP0002006_tumorigenesis1.24760007
49MP0005166_decreased_susceptibility_to1.23092282
50MP0005058_abnormal_lysosome_morphology1.12673847
51MP0005451_abnormal_body_composition1.07750443
52MP0002396_abnormal_hematopoietic_system1.06466272
53MP0002139_abnormal_hepatobiliary_system1.05095418
54MP0000858_altered_metastatic_potential1.04916729
55MP0003183_abnormal_peptide_metabolism1.03764053
56MP0001348_abnormal_lacrimal_gland1.03696341
57MP0009763_increased_sensitivity_to1.00913967
58MP0002998_abnormal_bone_remodeling0.97283101
59MP0003191_abnormal_cellular_cholesterol0.95641313
60MP0001851_eye_inflammation0.94733423
61MP0000604_amyloidosis0.89714716
62MP0003075_altered_response_to0.85787124
63MP0003252_abnormal_bile_duct0.85267690
64MP0005390_skeleton_phenotype0.84199846
65MP0003806_abnormal_nucleotide_metabolis0.81416650
66MP0002136_abnormal_kidney_physiology0.81230752
67MP0001663_abnormal_digestive_system0.81067695
68MP0004808_abnormal_hematopoietic_stem0.79783647
69MP0009643_abnormal_urine_homeostasis0.77886959
70MP0009278_abnormal_bone_marrow0.76521955
71MP0008260_abnormal_autophagy0.76469551
72MP0002019_abnormal_tumor_incidence0.76377508
73MP0000343_altered_response_to0.75843344
74MP0005084_abnormal_gallbladder_morpholo0.72843705
75MP0002132_abnormal_respiratory_system0.72538194
76MP0003172_abnormal_lysosome_physiology0.71584031
77MP0001545_abnormal_hematopoietic_system0.71506854
78MP0005397_hematopoietic_system_phenotyp0.71506854
79MP0000249_abnormal_blood_vessel0.71346191
80MP0004510_myositis0.66643973
81MP0001542_abnormal_bone_strength0.66578032
82MP0009765_abnormal_xenobiotic_induced0.64723446
83MP0003795_abnormal_bone_structure0.61809178
84MP0001765_abnormal_ion_homeostasis0.59385621
85MP0004883_abnormal_blood_vessel0.59100819
86MP0005360_urolithiasis0.57190876
87MP0005164_abnormal_response_to0.56073458
88MP0002693_abnormal_pancreas_physiology0.55324321
89MP0000490_abnormal_crypts_of0.54030601
90MP0006054_spinal_hemorrhage0.53863651
91MP0005083_abnormal_biliary_tract0.53593730
92MP0005075_abnormal_melanosome_morpholog0.52341803
93MP0003646_muscle_fatigue0.50077070
94MP0002009_preneoplasia0.49821091
95MP0000609_abnormal_liver_physiology0.49204430
96MP0005365_abnormal_bile_salt0.48422081
97MP0001501_abnormal_sleep_pattern0.47272559
98MP0003786_premature_aging0.45583409
99MP0001666_abnormal_nutrient_absorption0.44989530
100MP0005381_digestive/alimentary_phenotyp0.44553671

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.13014704
2Myositis (HP:0100614)4.70471264
3Stomatitis (HP:0010280)4.59775546
4Agammaglobulinemia (HP:0004432)4.50201134
5Abnormality of macrophages (HP:0004311)4.37315500
6Eczematoid dermatitis (HP:0000976)4.34917055
7Meningitis (HP:0001287)4.17051540
8Recurrent bacterial skin infections (HP:0005406)4.16086444
9Recurrent abscess formation (HP:0002722)4.13357814
10Recurrent bronchitis (HP:0002837)4.08783126
11T lymphocytopenia (HP:0005403)4.05747672
12Mediastinal lymphadenopathy (HP:0100721)3.95502372
13IgG deficiency (HP:0004315)3.94142780
14Orchitis (HP:0100796)3.94093037
15Retrobulbar optic neuritis (HP:0100654)3.92993092
16Optic neuritis (HP:0100653)3.92993092
17Abnormality of T cell number (HP:0011839)3.82344063
18Vasculitis (HP:0002633)3.69075741
19Obstructive lung disease (HP:0006536)3.68808538
20Chronic obstructive pulmonary disease (HP:0006510)3.68808538
21IgM deficiency (HP:0002850)3.63254397
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.54033316
23Abnormality of T cells (HP:0002843)3.40999356
24Gastrointestinal stroma tumor (HP:0100723)3.40370156
25Chronic diarrhea (HP:0002028)3.39309183
26Recurrent fungal infections (HP:0002841)3.31557081
27Recurrent viral infections (HP:0004429)3.31438228
28Lymphopenia (HP:0001888)3.29885980
29Encephalitis (HP:0002383)3.29734579
30Aplastic anemia (HP:0001915)3.29046402
31Pulmonary infiltrates (HP:0002113)3.27268106
32Pustule (HP:0200039)3.13516119
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.04346130
34Keratoconjunctivitis sicca (HP:0001097)2.95085067
35Autoimmune hemolytic anemia (HP:0001890)2.93489907
36Recurrent gram-negative bacterial infections (HP:0005420)2.90521507
37Petechiae (HP:0000967)2.86921193
38Recurrent skin infections (HP:0001581)2.84286358
39Cellulitis (HP:0100658)2.82963469
40Increased IgE level (HP:0003212)2.82172693
41Abnormality of liposaccharide metabolism (HP:0010968)2.80288373
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.80288373
43Abnormality of glycolipid metabolism (HP:0010969)2.80288373
44Panhypogammaglobulinemia (HP:0003139)2.79950217
45Keratoconjunctivitis (HP:0001096)2.78187993
46Chronic mucocutaneous candidiasis (HP:0002728)2.71446680
47Recurrent cutaneous fungal infections (HP:0011370)2.71446680
48Recurrent sinusitis (HP:0011108)2.68576044
49Abnormality of T cell physiology (HP:0011840)2.67139561
50Abnormality of B cell number (HP:0010975)2.66661682
51Increased IgM level (HP:0003496)2.66261979
52Abnormality of the pleura (HP:0002103)2.64173016
53Gastrointestinal inflammation (HP:0004386)2.61041119
54Severe combined immunodeficiency (HP:0004430)2.57580072
55Inflammation of the large intestine (HP:0002037)2.57016104
56Urticaria (HP:0001025)2.56548956
57Colitis (HP:0002583)2.52071739
58Abnormality of the prostate (HP:0008775)2.49889083
59Papilloma (HP:0012740)2.47827502
60Verrucae (HP:0200043)2.47827502
61Joint swelling (HP:0001386)2.46990375
62B lymphocytopenia (HP:0010976)2.43992458
63Bronchitis (HP:0012387)2.41309585
64Increased serum ferritin (HP:0003281)2.39976947
65Hypergammaglobulinemia (HP:0010702)2.39909245
66Chronic otitis media (HP:0000389)2.36432210
67Hypoproteinemia (HP:0003075)2.35169028
68Gangrene (HP:0100758)2.33784834
69Leukocytosis (HP:0001974)2.32566569
70Chest pain (HP:0100749)2.31805735
71Lymphoma (HP:0002665)2.30047769
72Hemoptysis (HP:0002105)2.29087636
73Hypoplasia of the thymus (HP:0000778)2.28251987
74Restrictive lung disease (HP:0002091)2.27768670
75Hypertensive crisis (HP:0100735)2.26086522
76Abnormality of eosinophils (HP:0001879)2.23950430
77Skin rash (HP:0000988)2.21087328
78Pulmonary embolism (HP:0002204)2.20799174
79Gastrointestinal infarctions (HP:0005244)2.19199855
80Purpura (HP:0000979)2.18959305
81Systemic lupus erythematosus (HP:0002725)2.15940712
82Combined immunodeficiency (HP:0005387)2.15650922
83Epistaxis (HP:0000421)2.15409573
84Granulocytopenia (HP:0001913)2.14785154
85Recurrent pneumonia (HP:0006532)2.14442970
86Osteomyelitis (HP:0002754)2.12766184
87Gingivitis (HP:0000230)2.12584818
88Arterial thrombosis (HP:0004420)2.12064894
89Emphysema (HP:0002097)2.12027722
90Sepsis (HP:0100806)2.11396918
91Increased cerebral lipofuscin (HP:0011813)2.09175425
92Glomerulopathy (HP:0100820)2.07434087
93Abnormality of iron homeostasis (HP:0011031)2.05792696
94Acne (HP:0001061)2.03793181
95Recurrent otitis media (HP:0000403)2.02976601
96Eosinophilia (HP:0001880)2.02125285
97Prolonged bleeding time (HP:0003010)2.01733163
98IgA deficiency (HP:0002720)1.99164984
99Progressive neurologic deterioration (HP:0002344)1.97723111
100Spontaneous hematomas (HP:0007420)1.93907965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.33052203
2TXK4.25208329
3TESK23.30988833
4ERN12.76784511
5KDR2.67515906
6RIPK42.63989437
7GRK62.33554027
8ZAP702.27445091
9MAP3K142.27350130
10TBK12.18264916
11SYK2.14032968
12MAP3K132.11004575
13BLK2.10155387
14JAK32.08975635
15IKBKE1.97102087
16BTK1.94762512
17SIK31.89087499
18MAP3K111.85672369
19SCYL21.84671504
20CSK1.84333873
21IKBKB1.82152253
22ITK1.80096285
23IRAK41.78209812
24FES1.66251640
25TYK21.64730019
26JAK11.60763027
27TEC1.58675448
28CSF1R1.48371618
29LCK1.48306228
30KIT1.46937056
31PRPF4B1.44834442
32TAOK31.44118162
33BCKDK1.41505387
34BMPR21.33693997
35TESK11.32071995
36MAPKAPK31.27948824
37LYN1.24904541
38PRKCQ1.12921160
39HCK1.09238639
40SIK21.05249232
41GRK71.04978926
42MATK0.98979573
43MAP2K30.97413676
44MAP2K60.97404577
45TNK20.92215642
46MAP3K30.86918968
47EPHA30.85051775
48PIM10.82535449
49JAK20.82125398
50EPHB10.81590385
51NME20.80647343
52IRAK30.80489812
53PIM20.80098553
54MARK30.79877156
55MAP4K20.76248439
56MAPK110.73566594
57FGFR40.73096619
58SIK10.69528350
59MAPK70.69494286
60IRAK10.66617992
61MAPKAPK20.65519729
62CHUK0.64997869
63FYN0.59520470
64MAP2K20.58397942
65PDK10.55974239
66TAOK20.55407509
67STK100.55061556
68ADRBK20.53422633
69HIPK20.51717517
70MAP3K50.50929391
71PIK3CG0.49758685
72RPS6KL10.49740588
73RPS6KC10.49740588
74DAPK10.49014087
75MST40.48300614
76FGR0.47486209
77TGFBR20.46427875
78MAP3K10.45987608
79MAPK40.45445866
80SMG10.44653477
81RPS6KA60.44385733
82TAOK10.42791786
83CAMKK20.42143950
84ICK0.41186675
85CLK10.38868962
86MAPK30.38221131
87ARAF0.37792217
88PRKG20.36416308
89MAPK120.34173840
90CDK40.32783052
91INSR0.31423324
92ABL10.30934682
93PDPK10.30697430
94CDC42BPA0.29249742
95TLK10.28258072
96RET0.28183961
97PRKCD0.27525658
98IGF1R0.26979571
99FGFR30.25231914
100CAMKK10.21984271

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.34129673
2Graft-versus-host disease_Homo sapiens_hsa053324.01001454
3Allograft rejection_Homo sapiens_hsa053303.97792858
4Autoimmune thyroid disease_Homo sapiens_hsa053203.71363712
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.37704335
6Asthma_Homo sapiens_hsa053103.09573515
7Type I diabetes mellitus_Homo sapiens_hsa049402.91710093
8Antigen processing and presentation_Homo sapiens_hsa046122.83915064
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.53013850
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51308662
11Leishmaniasis_Homo sapiens_hsa051402.48250050
12Hematopoietic cell lineage_Homo sapiens_hsa046402.32722519
13T cell receptor signaling pathway_Homo sapiens_hsa046602.16410116
14Staphylococcus aureus infection_Homo sapiens_hsa051502.15509905
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.10850223
16Viral myocarditis_Homo sapiens_hsa054162.08655012
17Rheumatoid arthritis_Homo sapiens_hsa053231.97403969
18B cell receptor signaling pathway_Homo sapiens_hsa046621.96857039
19Osteoclast differentiation_Homo sapiens_hsa043801.94848238
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89460768
21Measles_Homo sapiens_hsa051621.84676549
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65939989
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65751164
24Herpes simplex infection_Homo sapiens_hsa051681.63285494
25Influenza A_Homo sapiens_hsa051641.51669814
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48099984
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37276684
28Tuberculosis_Homo sapiens_hsa051521.36192331
29Toxoplasmosis_Homo sapiens_hsa051451.35682559
30TNF signaling pathway_Homo sapiens_hsa046681.32919589
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32054331
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.29701377
33Other glycan degradation_Homo sapiens_hsa005111.26379458
34Malaria_Homo sapiens_hsa051441.25088209
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17372993
36Chemokine signaling pathway_Homo sapiens_hsa040621.12617914
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10656067
38Pertussis_Homo sapiens_hsa051331.10572735
39Salmonella infection_Homo sapiens_hsa051321.04783523
40African trypanosomiasis_Homo sapiens_hsa051431.04738670
41Legionellosis_Homo sapiens_hsa051340.99976954
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94938203
43Shigellosis_Homo sapiens_hsa051310.88706560
44Apoptosis_Homo sapiens_hsa042100.88228986
45Hepatitis C_Homo sapiens_hsa051600.82145057
46Epstein-Barr virus infection_Homo sapiens_hsa051690.77080909
47Phagosome_Homo sapiens_hsa041450.74696140
48Acute myeloid leukemia_Homo sapiens_hsa052210.73711121
49Hepatitis B_Homo sapiens_hsa051610.72666010
50Platelet activation_Homo sapiens_hsa046110.71921345
51Systemic lupus erythematosus_Homo sapiens_hsa053220.71781754
52Lysosome_Homo sapiens_hsa041420.67122706
53HTLV-I infection_Homo sapiens_hsa051660.66181029
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63817415
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.62717532
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61222357
57Prolactin signaling pathway_Homo sapiens_hsa049170.51786273
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43610309
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43505685
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40599654
61Vitamin digestion and absorption_Homo sapiens_hsa049770.39565143
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.38762758
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.35435061
64Viral carcinogenesis_Homo sapiens_hsa052030.35244601
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34851723
66Arachidonic acid metabolism_Homo sapiens_hsa005900.33976345
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33036780
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32374515
69Endocytosis_Homo sapiens_hsa041440.31366429
70Non-small cell lung cancer_Homo sapiens_hsa052230.31085603
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.29693709
72Renin-angiotensin system_Homo sapiens_hsa046140.26915760
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26625837
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26562841
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24852783
76VEGF signaling pathway_Homo sapiens_hsa043700.24156100
77Caffeine metabolism_Homo sapiens_hsa002320.21854255
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21294414
79Insulin resistance_Homo sapiens_hsa049310.20860149
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.20482226
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17989045
82Linoleic acid metabolism_Homo sapiens_hsa005910.17947868
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17337214
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.17283114
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16939438
86Pancreatic cancer_Homo sapiens_hsa052120.13576705
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13345812
88Prion diseases_Homo sapiens_hsa050200.11954357
89MAPK signaling pathway_Homo sapiens_hsa040100.10421788
90Glycerolipid metabolism_Homo sapiens_hsa005610.09246587
91Chronic myeloid leukemia_Homo sapiens_hsa052200.08424422
92Chemical carcinogenesis_Homo sapiens_hsa052040.08229881
93Fat digestion and absorption_Homo sapiens_hsa049750.07754836
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07696206
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.05678690
96Amoebiasis_Homo sapiens_hsa051460.05605903
97Galactose metabolism_Homo sapiens_hsa000520.05442951
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.05014605
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.04178451
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03802567

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