HCG9P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.26484307
2leukotriene biosynthetic process (GO:0019370)6.23867850
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21091352
4cysteine metabolic process (GO:0006534)5.09574075
5positive regulation of gamma-delta T cell activation (GO:0046645)4.66688824
6regulation of regulatory T cell differentiation (GO:0045589)4.62955379
7leukotriene metabolic process (GO:0006691)4.53370645
8peptide catabolic process (GO:0043171)4.52099515
9DNA deamination (GO:0045006)4.46667545
10pyrimidine nucleoside catabolic process (GO:0046135)4.42084007
11positive regulation of B cell differentiation (GO:0045579)3.95183778
12negative T cell selection (GO:0043383)3.89037720
13activated T cell proliferation (GO:0050798)3.78565941
14regulation of memory T cell differentiation (GO:0043380)3.74097261
15cellular defense response (GO:0006968)3.72887407
16regulation of gamma-delta T cell differentiation (GO:0045586)3.39219261
17negative regulation of cAMP-mediated signaling (GO:0043951)3.38247836
18detection of molecule of bacterial origin (GO:0032490)3.34333030
19membrane raft organization (GO:0031579)3.33426969
20positive T cell selection (GO:0043368)3.32070263
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.28648524
22negative regulation of viral genome replication (GO:0045071)3.26668789
23peptidyl-glutamic acid carboxylation (GO:0017187)3.25503551
24protein carboxylation (GO:0018214)3.25503551
25icosanoid biosynthetic process (GO:0046456)3.23655188
26fatty acid derivative biosynthetic process (GO:1901570)3.23655188
27regulation of gamma-delta T cell activation (GO:0046643)3.18450741
28negative regulation of T cell apoptotic process (GO:0070233)3.16870829
29unsaturated fatty acid biosynthetic process (GO:0006636)3.13269901
30negative regulation of viral release from host cell (GO:1902187)3.03667945
31DNA demethylation (GO:0080111)3.03324096
32regulation of B cell differentiation (GO:0045577)2.95842475
33protein retention in ER lumen (GO:0006621)2.95793348
34regulation of histone H3-K27 methylation (GO:0061085)2.93990504
35positive regulation of macrophage differentiation (GO:0045651)2.89595947
36cell proliferation involved in metanephros development (GO:0072203)2.88827220
37T cell migration (GO:0072678)2.83561715
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.80773771
39positive regulation of natural killer cell mediated immunity (GO:0002717)2.79143656
40disruption of cells of other organism (GO:0044364)2.78853024
41killing of cells of other organism (GO:0031640)2.78853024
42cytolysis (GO:0019835)2.78827423
43defense response to fungus (GO:0050832)2.77229827
44response to interleukin-15 (GO:0070672)2.76287955
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74149284
46pathway-restricted SMAD protein phosphorylation (GO:0060389)2.72707188
47regulation of phospholipase A2 activity (GO:0032429)2.69749620
48cellular response to interleukin-15 (GO:0071350)2.69611151
49macrophage chemotaxis (GO:0048246)2.68978383
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.65456608
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.61218399
52positive regulation of interleukin-8 secretion (GO:2000484)2.56016014
53positive regulation of humoral immune response (GO:0002922)2.53674156
54mannose metabolic process (GO:0006013)2.51518316
55negative regulation of viral process (GO:0048525)2.51240027
56T cell selection (GO:0045058)2.51066355
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50526334
58DNA dealkylation (GO:0035510)2.48404248
59eosinophil chemotaxis (GO:0048245)2.48146904
60negative regulation of fatty acid transport (GO:2000192)2.47521053
61cellular extravasation (GO:0045123)2.47161692
62pyrimidine ribonucleoside metabolic process (GO:0046131)2.44540598
63lymphocyte chemotaxis (GO:0048247)2.44243426
64positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.42917106
65positive regulation of tolerance induction (GO:0002645)2.41700532
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39332693
67negative regulation of cell killing (GO:0031342)2.39332693
68negative regulation of fibrinolysis (GO:0051918)2.38434530
69membrane protein ectodomain proteolysis (GO:0006509)2.37854606
70cell adhesion mediated by integrin (GO:0033627)2.36776101
71membrane protein proteolysis (GO:0033619)2.34178722
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.33740877
73regulation of natural killer cell mediated immunity (GO:0002715)2.33740877
74extracellular matrix assembly (GO:0085029)2.32542981
75regulation of necroptotic process (GO:0060544)2.32136227
76regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.31919947
77negative regulation of stress fiber assembly (GO:0051497)2.31122281
78pentose-phosphate shunt (GO:0006098)2.28655724
79blood vessel maturation (GO:0001955)2.27887624
80regulation of viral genome replication (GO:0045069)2.27712837
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.27578744
82eosinophil migration (GO:0072677)2.25790212
83positive regulation of T cell mediated cytotoxicity (GO:0001916)2.23959660
84regulation of activation of Janus kinase activity (GO:0010533)2.23122832
85myeloid dendritic cell differentiation (GO:0043011)2.22999794
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.20963918
87negative regulation of bone mineralization (GO:0030502)2.19875082
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.19487032
89regulation of B cell receptor signaling pathway (GO:0050855)2.19409999
90carbohydrate phosphorylation (GO:0046835)2.18404666
91negative thymic T cell selection (GO:0045060)2.18401732
92alanine transport (GO:0032328)2.16108978
93regulation of lymphocyte chemotaxis (GO:1901623)2.15495180
94protein targeting to Golgi (GO:0000042)2.15324539
95chondroitin sulfate catabolic process (GO:0030207)2.15274042
96mesonephros development (GO:0001823)2.15111870
97sulfur compound catabolic process (GO:0044273)2.14152387
98cytidine deamination (GO:0009972)10.0969238
99cytidine metabolic process (GO:0046087)10.0969238
100cytidine catabolic process (GO:0006216)10.0969238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.12821501
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.63465516
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.55081697
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05611325
5SCL_19346495_ChIP-Seq_HPC-7_Human2.94010721
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79285293
7GATA1_22025678_ChIP-Seq_K562_Human2.68557035
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.60955367
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29990446
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.17145591
11RUNX_20019798_ChIP-Seq_JUKART_Human2.13515355
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09019576
13GATA1_19941826_ChIP-Seq_K562_Human2.06983154
14MYB_26560356_Chip-Seq_TH2_Human2.06319997
15EGR1_19032775_ChIP-ChIP_M12_Human1.97185159
16GATA3_27048872_Chip-Seq_THYMUS_Human1.93232380
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90232852
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88231479
19MYB_26560356_Chip-Seq_TH1_Human1.86282781
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.85928822
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85844615
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85225459
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.83821731
24MAF_26560356_Chip-Seq_TH1_Human1.80264038
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76748862
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76363307
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74439623
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.70145987
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70068348
30LXR_22292898_ChIP-Seq_THP-1_Human1.69672786
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67947877
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60937970
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.59540123
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57511126
35SPI1_23127762_ChIP-Seq_K562_Human1.57125594
36MAF_26560356_Chip-Seq_TH2_Human1.55879629
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54749856
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53468191
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51848476
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51637418
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.48796470
42RXR_22108803_ChIP-Seq_LS180_Human1.48383885
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46777954
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.45448693
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.45438830
46UTX_26944678_Chip-Seq_JUKART_Human1.43127931
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40552501
48GATA2_19941826_ChIP-Seq_K562_Human1.40192057
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38193360
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36849852
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33164918
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.31224690
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30273917
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26316229
55KDM2B_26808549_Chip-Seq_DND41_Human1.25661778
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24697839
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.22937693
58VDR_24763502_ChIP-Seq_THP-1_Human1.22575993
59CLOCK_20551151_ChIP-Seq_293T_Human1.20419588
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20220946
61TP53_16413492_ChIP-PET_HCT116_Human1.19924573
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19713334
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19464579
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18457887
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18068472
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17561744
67VDR_24787735_ChIP-Seq_THP-1_Human1.17332269
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16254176
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15057872
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12852599
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.08959619
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.08959619
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08411683
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.07228205
75NCOR1_26117541_ChIP-Seq_K562_Human1.06674131
76GATA3_26560356_Chip-Seq_TH2_Human1.06215779
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06070027
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06042316
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04463982
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03498047
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03241248
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.03134152
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02724314
84TCF7_22412390_ChIP-Seq_EML_Mouse1.01328627
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00262461
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00208843
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00159112
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99894330
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98418496
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98246711
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97731734
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97161884
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96994228
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96762549
95RACK7_27058665_Chip-Seq_MCF-7_Human0.96721937
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.95809431
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95786698
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.94843003
99VDR_21846776_ChIP-Seq_THP-1_Human0.91444333
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91262221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.52815917
2MP0003763_abnormal_thymus_physiology3.39498693
3MP0008260_abnormal_autophagy3.20196086
4MP0005671_abnormal_response_to2.75813511
5MP0006082_CNS_inflammation2.52029587
6MP0001958_emphysema2.45090029
7MP0005451_abnormal_body_composition2.41830141
8MP0002163_abnormal_gland_morphology2.23838694
9MP0008438_abnormal_cutaneous_collagen2.17706040
10MP0006054_spinal_hemorrhage2.12385485
11MP0002166_altered_tumor_susceptibility2.10048960
12MP0002009_preneoplasia2.08394371
13MP0004272_abnormal_basement_membrane2.06115501
14MP0009333_abnormal_splenocyte_physiolog2.05455812
15MP0003279_aneurysm2.03192599
16MP0003091_abnormal_cell_migration1.96670288
17MP0003566_abnormal_cell_adhesion1.85059904
18MP0005379_endocrine/exocrine_gland_phen1.58310960
19MP0008004_abnormal_stomach_pH1.55086646
20MP0003191_abnormal_cellular_cholesterol1.53861081
21MP0002269_muscular_atrophy1.53014443
22MP0000767_abnormal_smooth_muscle1.48735456
23MP0002420_abnormal_adaptive_immunity1.47880256
24MP0002723_abnormal_immune_serum1.47418454
25MP0004019_abnormal_vitamin_homeostasis1.47338344
26MP0003705_abnormal_hypodermis_morpholog1.45975856
27MP0000703_abnormal_thymus_morphology1.43344741
28MP0001819_abnormal_immune_cell1.43083177
29MP0005025_abnormal_response_to1.41300384
30MP0000858_altered_metastatic_potential1.40623209
31MP0001800_abnormal_humoral_immune1.40437992
32MP0001661_extended_life_span1.39699411
33MP0000716_abnormal_immune_system1.38754221
34MP0004883_abnormal_blood_vessel1.36975193
35MP0005000_abnormal_immune_tolerance1.34831952
36MP0002419_abnormal_innate_immunity1.34201992
37MP0003448_altered_tumor_morphology1.33822308
38MP0003656_abnormal_erythrocyte_physiolo1.33366684
39MP0009785_altered_susceptibility_to1.31532916
40MP0003300_gastrointestinal_ulcer1.29589597
41MP0002398_abnormal_bone_marrow1.29008931
42MP0000689_abnormal_spleen_morphology1.27694840
43MP0001835_abnormal_antigen_presentation1.25831730
44MP0002139_abnormal_hepatobiliary_system1.25458888
45MP0002998_abnormal_bone_remodeling1.25077078
46MP0002132_abnormal_respiratory_system1.24323879
47MP0000685_abnormal_immune_system1.23797427
48MP0004947_skin_inflammation1.22616858
49MP0009763_increased_sensitivity_to1.21836789
50MP0002722_abnormal_immune_system1.21489008
51MP0002405_respiratory_system_inflammati1.20807710
52MP0008469_abnormal_protein_level1.20580230
53MP0001756_abnormal_urination1.19794008
54MP0001790_abnormal_immune_system1.17893748
55MP0005387_immune_system_phenotype1.17893748
56MP0002452_abnormal_antigen_presenting1.13386683
57MP0002429_abnormal_blood_cell1.13065359
58MP0005058_abnormal_lysosome_morphology1.12926939
59MP0002877_abnormal_melanocyte_morpholog1.12768586
60MP0003436_decreased_susceptibility_to1.12174732
61MP0002006_tumorigenesis1.12135195
62MP0010368_abnormal_lymphatic_system1.11882959
63MP0003795_abnormal_bone_structure1.09830970
64MP0000003_abnormal_adipose_tissue1.09152597
65MP0004233_abnormal_muscle_weight1.08639941
66MP0005508_abnormal_skeleton_morphology1.08558452
67MP0002089_abnormal_postnatal_growth/wei1.04315390
68MP0000639_abnormal_adrenal_gland1.02532781
69MP0005584_abnormal_enzyme/coenzyme_acti1.02418624
70MP0005375_adipose_tissue_phenotype1.00755384
71MP0002971_abnormal_brown_adipose0.99704734
72MP0000566_synostosis0.99166938
73MP0005503_abnormal_tendon_morphology0.98949180
74MP0003567_abnormal_fetal_cardiomyocyte0.97839425
75MP0005164_abnormal_response_to0.97542225
76MP0000733_abnormal_muscle_development0.95389175
77MP0002136_abnormal_kidney_physiology0.93192660
78MP0010155_abnormal_intestine_physiology0.92928070
79MP0004484_altered_response_of0.92815947
80MP0002933_joint_inflammation0.92199336
81MP0000613_abnormal_salivary_gland0.90222884
82MP0001845_abnormal_inflammatory_respons0.89750035
83MP0005023_abnormal_wound_healing0.89653556
84MP0000749_muscle_degeneration0.88707624
85MP0002148_abnormal_hypersensitivity_rea0.85774652
86MP0003172_abnormal_lysosome_physiology0.84989519
87MP0005275_abnormal_skin_tensile0.84700787
88MP0009765_abnormal_xenobiotic_induced0.83005112
89MP0009115_abnormal_fat_cell0.82525916
90MP0004087_abnormal_muscle_fiber0.82147510
91MP0004084_abnormal_cardiac_muscle0.81730267
92MP0003221_abnormal_cardiomyocyte_apopto0.81567936
93MP0002108_abnormal_muscle_morphology0.81255868
94MP0000537_abnormal_urethra_morphology0.81092775
95MP0000013_abnormal_adipose_tissue0.80419389
96MP0000249_abnormal_blood_vessel0.79228182
97MP0004264_abnormal_extraembryonic_tissu0.78930171
98MP0002127_abnormal_cardiovascular_syste0.78629985
99MP0003075_altered_response_to0.76024377
100MP0005666_abnormal_adipose_tissue0.75475587

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.66882105
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.66882105
3Abnormality of glycolipid metabolism (HP:0010969)5.66882105
4T lymphocytopenia (HP:0005403)5.18695268
5Vertebral arch anomaly (HP:0008438)4.52252287
6Abnormality of T cell number (HP:0011839)4.42110494
7Broad ribs (HP:0000885)4.11254602
8Aortic regurgitation (HP:0001659)3.86856545
9Broad alveolar ridges (HP:0000187)3.83991834
10J-shaped sella turcica (HP:0002680)3.53979368
11Autoimmune hemolytic anemia (HP:0001890)3.43517432
12Abnormality of the lumbar spine (HP:0100712)3.42569463
13Flat acetabular roof (HP:0003180)3.40935248
14Deep venous thrombosis (HP:0002625)3.33582876
15Carpal bone hypoplasia (HP:0001498)3.23843201
16Increased cerebral lipofuscin (HP:0011813)3.22334444
17Aplastic anemia (HP:0001915)3.11187704
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.09449504
19Recurrent bronchitis (HP:0002837)2.94801114
20Flared iliac wings (HP:0002869)2.93623991
21Autoimmune thrombocytopenia (HP:0001973)2.89403910
22Abnormality of T cells (HP:0002843)2.81154434
23Recurrent viral infections (HP:0004429)2.74813450
24Cholecystitis (HP:0001082)2.70790645
25Abnormal gallbladder physiology (HP:0012438)2.70790645
26Granulocytopenia (HP:0001913)2.67445845
27Protrusio acetabuli (HP:0003179)2.67060710
28Thoracic kyphosis (HP:0002942)2.63458500
29Abnormality of eosinophils (HP:0001879)2.61426220
30Prolonged partial thromboplastin time (HP:0003645)2.60985123
31Abnormality of the alveolar ridges (HP:0006477)2.60708611
32Diastasis recti (HP:0001540)2.60643829
33Thoracolumbar scoliosis (HP:0002944)2.59005594
34Reticulocytosis (HP:0001923)2.58960644
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53791941
36Premature rupture of membranes (HP:0001788)2.53269892
37Slow saccadic eye movements (HP:0000514)2.51681898
38Eosinophilia (HP:0001880)2.50574922
39Urinary glycosaminoglycan excretion (HP:0003541)2.48863078
40Mucopolysacchariduria (HP:0008155)2.48863078
41Thickened calvaria (HP:0002684)2.46959471
42Vertebral compression fractures (HP:0002953)2.45771689
43Joint hemorrhage (HP:0005261)2.39931713
44Mitral stenosis (HP:0001718)2.37550545
45Dysostosis multiplex (HP:0000943)2.34780753
46Hypoplasia of the thymus (HP:0000778)2.31148645
47Nonimmune hydrops fetalis (HP:0001790)2.25769530
48Abnormality of polysaccharide metabolism (HP:0011012)2.25199600
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25199600
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25199600
51Abnormality of macrophages (HP:0004311)2.25138848
52Deformed sella turcica (HP:0002681)2.23811256
53Protuberant abdomen (HP:0001538)2.18739253
54Pustule (HP:0200039)2.16130606
55Aortic dissection (HP:0002647)2.12082013
56Abnormality of the thoracic spine (HP:0100711)2.11598612
57Papilledema (HP:0001085)2.11057294
58Aortic aneurysm (HP:0004942)2.08555955
59Hematochezia (HP:0002573)2.08354821
60Dislocated radial head (HP:0003083)2.04767119
61Abnormality of the common coagulation pathway (HP:0010990)2.04744436
62Asymmetry of the thorax (HP:0001555)2.04291985
63Craniofacial hyperostosis (HP:0004493)2.02796333
64Severe combined immunodeficiency (HP:0004430)2.02028949
65Biconcave vertebral bodies (HP:0004586)1.99598162
66Glucose intolerance (HP:0000833)1.97408603
67Nonprogressive disorder (HP:0003680)1.96415859
68Corneal dystrophy (HP:0001131)1.95092349
69Hypoplasia of the odontoid process (HP:0003311)1.92772300
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86964144
71Chronic mucocutaneous candidiasis (HP:0002728)1.86740651
72Recurrent cutaneous fungal infections (HP:0011370)1.86740651
73Combined immunodeficiency (HP:0005387)1.86652984
74Genetic anticipation (HP:0003743)1.86570917
75Ectopia lentis (HP:0001083)1.85767303
76Broad palm (HP:0001169)1.85608681
77Beaking of vertebral bodies (HP:0004568)1.85551705
78Striae distensae (HP:0001065)1.82577857
79Ovoid vertebral bodies (HP:0003300)1.81299099
80Spontaneous hematomas (HP:0007420)1.79732954
81Menstrual irregularities (HP:0000858)1.79049504
82Abnormality of the radial head (HP:0003995)1.78755691
83Menorrhagia (HP:0000132)1.78520400
84Megalocornea (HP:0000485)1.77248945
85Acute hepatic failure (HP:0006554)1.76346435
86Nasolacrimal duct obstruction (HP:0000579)1.75855569
87Abnormality of the humeroradial joint (HP:0100744)1.73922163
88Purpura (HP:0000979)1.73854678
89Ureteral stenosis (HP:0000071)1.73853093
90Breech presentation (HP:0001623)1.72408112
91Asymmetric septal hypertrophy (HP:0001670)1.72049404
92Leukocytosis (HP:0001974)1.71398622
93Joint swelling (HP:0001386)1.71219816
94Hemorrhage of the eye (HP:0011885)1.70404225
95Microglossia (HP:0000171)1.69868513
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68982696
97Cranial hyperostosis (HP:0004437)1.68197859
98Abnormality of the intrinsic pathway (HP:0010989)1.67751058
99Death in childhood (HP:0003819)1.67019339
100Abnormality of the odontoid process (HP:0003310)1.65845237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.79496815
2CDK122.94125951
3PRPF4B2.80519760
4RIPK42.78619193
5ICK2.76015347
6STK382.43764652
7WNK42.32519275
8MAP4K12.28106384
9FGFR42.22394214
10MAP3K62.20564076
11MAP2K72.06199498
12ITK2.03056948
13DYRK31.95820910
14RIPK11.95563226
15WNK11.93600527
16BMPR21.86679368
17TTN1.77962290
18PIK3CA1.73629825
19CAMKK21.63461698
20MAP4K21.50553165
21JAK31.42290809
22NEK91.40161657
23TYRO31.34502860
24LATS11.31013180
25MAPKAPK31.27269397
26FES1.25701076
27RPS6KA41.25375399
28FGFR31.22532183
29MAP3K21.21903389
30HIPK21.19587671
31MAP3K71.16760373
32CDC42BPA1.14910869
33RET1.12448221
34TNK21.10798099
35SGK31.10658045
36EEF2K1.08716280
37KDR1.07250559
38TRIB31.06126060
39PTK2B1.04084091
40CAMK41.00819573
41MAPK120.99333519
42KIT0.99190670
43EPHB10.95038921
44JAK10.93892025
45TGFBR20.91258589
46MAP2K30.90916480
47TYK20.89167435
48ERN10.88819061
49NLK0.88715112
50FGFR10.88060759
51ZAP700.84072242
52SGK2230.84055282
53SGK4940.84055282
54DYRK1B0.81004273
55SGK20.80183066
56LCK0.79807238
57MAPK110.79465764
58CSK0.78556994
59AKT20.75518857
60BLK0.75356311
61OBSCN0.75155297
62BTK0.74575178
63BCKDK0.73838030
64RPS6KA60.69599213
65LYN0.67559849
66RPS6KL10.65310384
67RPS6KC10.65310384
68NEK60.64858613
69PDK10.64462147
70EIF2AK30.63525418
71MYLK0.63061384
72SIK10.63018247
73CDK60.62818083
74PDPK10.62177201
75IRAK20.61474285
76TAOK30.60777494
77PKN20.60296960
78MAP3K50.60111064
79PDGFRA0.58400595
80FYN0.56288607
81MTOR0.55383086
82MAP3K10.54862922
83KSR20.52698247
84TIE10.52165328
85MAPK70.51400562
86SYK0.50487268
87CAMKK10.50329905
88YES10.48475074
89IRAK10.48004821
90PIM10.47742649
91CDK80.46139218
92MELK0.45955258
93MAPKAPK20.45857590
94PDGFRB0.45467926
95MAP3K140.44371196
96PAK20.43535783
97TRPM70.41736269
98RPS6KB10.41057420
99JAK20.40779281
100MARK30.40054077

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.32238099
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.00293255
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50716002
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41722317
5T cell receptor signaling pathway_Homo sapiens_hsa046602.35205042
6Complement and coagulation cascades_Homo sapiens_hsa046102.24650964
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05791636
8Primary immunodeficiency_Homo sapiens_hsa053401.95156242
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91398999
10VEGF signaling pathway_Homo sapiens_hsa043701.84491708
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.81538445
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77296415
13Antigen processing and presentation_Homo sapiens_hsa046121.77249843
14B cell receptor signaling pathway_Homo sapiens_hsa046621.59714318
15Hematopoietic cell lineage_Homo sapiens_hsa046401.57219301
16Osteoclast differentiation_Homo sapiens_hsa043801.55032291
17Fatty acid elongation_Homo sapiens_hsa000621.46070007
18Malaria_Homo sapiens_hsa051441.44266565
19Lysosome_Homo sapiens_hsa041421.39582512
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.35088853
21ABC transporters_Homo sapiens_hsa020101.29798091
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29496738
23Pertussis_Homo sapiens_hsa051331.27802345
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22121739
25Staphylococcus aureus infection_Homo sapiens_hsa051501.20504751
26Measles_Homo sapiens_hsa051621.15370753
27Long-term potentiation_Homo sapiens_hsa047201.13307881
28TNF signaling pathway_Homo sapiens_hsa046681.11586735
29Circadian rhythm_Homo sapiens_hsa047101.11492042
30Fructose and mannose metabolism_Homo sapiens_hsa000511.08593341
31Glucagon signaling pathway_Homo sapiens_hsa049221.08252231
32Renin secretion_Homo sapiens_hsa049241.05737917
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95878567
34Galactose metabolism_Homo sapiens_hsa000520.94324313
35Other glycan degradation_Homo sapiens_hsa005110.93162837
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92480087
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89441529
38Focal adhesion_Homo sapiens_hsa045100.89207942
39Pentose phosphate pathway_Homo sapiens_hsa000300.88467122
40ECM-receptor interaction_Homo sapiens_hsa045120.88344023
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86415283
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86123957
43Salmonella infection_Homo sapiens_hsa051320.85971377
44Graft-versus-host disease_Homo sapiens_hsa053320.85057337
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.84712686
46Steroid biosynthesis_Homo sapiens_hsa001000.83010897
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81137528
48Prion diseases_Homo sapiens_hsa050200.79786670
49Amphetamine addiction_Homo sapiens_hsa050310.77867192
50Regulation of autophagy_Homo sapiens_hsa041400.76711550
51Oxytocin signaling pathway_Homo sapiens_hsa049210.76147191
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75347968
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.73924205
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73566569
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.70955843
56Platelet activation_Homo sapiens_hsa046110.68884703
57Acute myeloid leukemia_Homo sapiens_hsa052210.68202456
58Non-small cell lung cancer_Homo sapiens_hsa052230.68045553
59Dilated cardiomyopathy_Homo sapiens_hsa054140.65694663
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63992311
61Tuberculosis_Homo sapiens_hsa051520.63902571
62Autoimmune thyroid disease_Homo sapiens_hsa053200.63490860
63African trypanosomiasis_Homo sapiens_hsa051430.63447881
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62730564
65Insulin resistance_Homo sapiens_hsa049310.61758358
66Amoebiasis_Homo sapiens_hsa051460.61050034
67Hepatitis B_Homo sapiens_hsa051610.59659780
68Lysine degradation_Homo sapiens_hsa003100.59142552
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59094792
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.57250969
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55121169
72Fatty acid biosynthesis_Homo sapiens_hsa000610.54890632
73Small cell lung cancer_Homo sapiens_hsa052220.53443294
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52711911
75HTLV-I infection_Homo sapiens_hsa051660.52524665
76Renin-angiotensin system_Homo sapiens_hsa046140.51128842
77Allograft rejection_Homo sapiens_hsa053300.50920837
78Influenza A_Homo sapiens_hsa051640.50062832
79Biosynthesis of amino acids_Homo sapiens_hsa012300.50023774
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49639141
81Chemokine signaling pathway_Homo sapiens_hsa040620.48355495
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47623245
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45837356
84GnRH signaling pathway_Homo sapiens_hsa049120.45628257
85Choline metabolism in cancer_Homo sapiens_hsa052310.44637031
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44505535
87Notch signaling pathway_Homo sapiens_hsa043300.44458266
88Fatty acid degradation_Homo sapiens_hsa000710.43139699
89Arachidonic acid metabolism_Homo sapiens_hsa005900.43122062
90Thyroid hormone synthesis_Homo sapiens_hsa049180.42264902
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42243509
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41671828
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40549113
94Caffeine metabolism_Homo sapiens_hsa002320.40269829
95FoxO signaling pathway_Homo sapiens_hsa040680.40168253
96AMPK signaling pathway_Homo sapiens_hsa041520.38584386
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.37857433
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37588601
99Apoptosis_Homo sapiens_hsa042100.37527148
100Bladder cancer_Homo sapiens_hsa052190.37098114

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