HCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.85951922
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.85951922
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.85951922
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.85951922
5modulation by symbiont of host immune response (GO:0052553)6.85951922
6positive regulation by symbiont of host defense response (GO:0052509)6.85951922
7neutrophil activation involved in immune response (GO:0002283)5.82865579
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78471037
9negative regulation of cell killing (GO:0031342)5.78471037
10response to peptidoglycan (GO:0032494)5.72913205
11macrophage activation involved in immune response (GO:0002281)5.37279711
12positive regulation of interferon-alpha production (GO:0032727)5.26972267
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.12203727
14immunoglobulin mediated immune response (GO:0016064)5.11424491
15regulation of interferon-beta biosynthetic process (GO:0045357)5.08579094
16regulation of interferon-alpha production (GO:0032647)5.01687315
17detection of other organism (GO:0098543)4.85482856
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.81666560
19response to host immune response (GO:0052572)4.81666560
20detection of bacterium (GO:0016045)4.59015048
21granulocyte activation (GO:0036230)4.45704660
22microglial cell activation (GO:0001774)4.39590833
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.38895688
24response to host (GO:0075136)4.38895688
25response to host defenses (GO:0052200)4.38895688
26leukocyte aggregation (GO:0070486)4.35740872
27neutrophil activation (GO:0042119)4.34676822
28* respiratory burst (GO:0045730)4.30979947
29detection of external biotic stimulus (GO:0098581)4.28992865
30positive regulation of chemokine biosynthetic process (GO:0045080)4.25462955
31hydrogen peroxide biosynthetic process (GO:0050665)4.13220861
32antigen processing and presentation of endogenous antigen (GO:0019883)4.12056976
33positive regulation of mast cell degranulation (GO:0043306)4.10503253
34positive regulation of mast cell activation involved in immune response (GO:0033008)4.10503253
35regulation of gamma-delta T cell activation (GO:0046643)4.04495429
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95681755
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95681755
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.94469920
39regulation of B cell receptor signaling pathway (GO:0050855)3.93620755
40positive regulation of mast cell activation (GO:0033005)3.92725745
41* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.91433912
42myeloid cell activation involved in immune response (GO:0002275)3.85050747
43positive regulation of gamma-delta T cell activation (GO:0046645)3.83815887
44regulation of mast cell degranulation (GO:0043304)3.83394301
45macrophage activation (GO:0042116)3.82117951
46positive regulation of interferon-beta production (GO:0032728)3.81821244
47positive regulation of antigen processing and presentation (GO:0002579)3.79989261
48detection of biotic stimulus (GO:0009595)3.79980059
49type I interferon signaling pathway (GO:0060337)3.78937185
50cellular response to type I interferon (GO:0071357)3.78937185
51B cell mediated immunity (GO:0019724)3.78872194
52response to muramyl dipeptide (GO:0032495)3.78364847
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.76075918
54response to type I interferon (GO:0034340)3.75874192
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73533187
56reactive oxygen species biosynthetic process (GO:1903409)3.71129715
57production of molecular mediator involved in inflammatory response (GO:0002532)3.67955851
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66676563
59regulation of mast cell activation involved in immune response (GO:0033006)3.60090150
60leukocyte migration involved in inflammatory response (GO:0002523)3.55065166
61superoxide anion generation (GO:0042554)3.53697021
62negative regulation of T cell mediated immunity (GO:0002710)3.51393772
63positive regulation of toll-like receptor signaling pathway (GO:0034123)3.48955155
64positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.45571989
65regulation of mast cell activation (GO:0033003)3.43857624
66positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.43508205
67negative regulation of interleukin-12 production (GO:0032695)3.42549337
68positive regulation of cellular amide metabolic process (GO:0034250)3.41852661
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40700948
70negative regulation of leukocyte mediated immunity (GO:0002704)3.40236663
71regulation of chemokine biosynthetic process (GO:0045073)3.39204710
72* interferon-gamma-mediated signaling pathway (GO:0060333)3.39194658
73regulation of T cell tolerance induction (GO:0002664)3.39133586
74neutrophil mediated immunity (GO:0002446)3.37193535
75positive regulation of leukocyte degranulation (GO:0043302)3.36676507
76cellular extravasation (GO:0045123)3.33901780
77regulation of tolerance induction (GO:0002643)3.31987433
78natural killer cell mediated immunity (GO:0002228)3.31549351
79natural killer cell mediated cytotoxicity (GO:0042267)3.31549351
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.30779086
81defense response to protozoan (GO:0042832)3.25428765
82leukocyte mediated cytotoxicity (GO:0001909)3.24754422
83regulation of antigen processing and presentation (GO:0002577)3.21264648
84detection of molecule of bacterial origin (GO:0032490)3.21078292
85regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18757832
86negative regulation of cytokine production involved in immune response (GO:0002719)3.18610994
87regulation of gamma-delta T cell differentiation (GO:0045586)3.16727112
88regulation of leukocyte degranulation (GO:0043300)3.16468632
89response to interleukin-15 (GO:0070672)3.14864687
90regulation of T-helper 2 cell differentiation (GO:0045628)3.14004097
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13160941
92T-helper 1 type immune response (GO:0042088)3.10339970
93I-kappaB phosphorylation (GO:0007252)3.10020619
94positive regulation of B cell differentiation (GO:0045579)3.07200636
95positive regulation of heat generation (GO:0031652)3.05393961
96negative regulation of erythrocyte differentiation (GO:0045647)3.04030350
97neutrophil chemotaxis (GO:0030593)3.02732853
98negative regulation of myeloid cell apoptotic process (GO:0033033)3.01248675
99B cell receptor signaling pathway (GO:0050853)3.01239317
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99644989
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98675952
102myeloid leukocyte activation (GO:0002274)2.97507708
103cellular response to interferon-beta (GO:0035458)2.96961559
104positive regulation of type 2 immune response (GO:0002830)2.96939606
105regulation of interferon-beta production (GO:0032648)2.96425076
106leukocyte cell-cell adhesion (GO:0007159)2.95437368
107myeloid leukocyte mediated immunity (GO:0002444)2.95276504
108antigen processing and presentation via MHC class Ib (GO:0002475)2.95188954
109negative regulation of mast cell activation (GO:0033004)2.94980799
110NIK/NF-kappaB signaling (GO:0038061)2.94735683
111neutrophil migration (GO:1990266)2.93885319
112cellular response to zinc ion (GO:0071294)2.93652168
113regulation of B cell differentiation (GO:0045577)2.93337731
114regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92923242
115response to interferon-alpha (GO:0035455)2.92850635
116positive regulation of chemokine production (GO:0032722)2.92809403
117regulation of interleukin-8 biosynthetic process (GO:0045414)2.92383525
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92162326
119regulation of fever generation (GO:0031620)2.88844475
120T cell migration (GO:0072678)2.88232625
121lymphocyte mediated immunity (GO:0002449)2.85594751
122negative regulation of interleukin-6 production (GO:0032715)2.85409751
123negative regulation of innate immune response (GO:0045824)2.85373156
124cellular response to interleukin-15 (GO:0071350)2.84372502
125response to protozoan (GO:0001562)2.82205335
126regulation of regulated secretory pathway (GO:1903305)2.81819968
127negative regulation of viral genome replication (GO:0045071)2.81445030
128Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80665164
129regulation of interferon-gamma biosynthetic process (GO:0045072)2.79736088
130cytokine secretion (GO:0050663)2.77669855
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.77669386
132germinal center formation (GO:0002467)2.77554398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.09809170
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.79129175
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.45781049
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.51633099
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.15418666
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.08360660
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.05352658
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67490096
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46350909
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.28490120
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21005958
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.07011781
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.04402655
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96575686
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81821826
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.79422704
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66867104
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52864836
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43292314
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.41200496
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37115158
22SPI1_23547873_ChIP-Seq_NB4_Human2.33912342
23VDR_24763502_ChIP-Seq_THP-1_Human1.97048940
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95694252
25VDR_21846776_ChIP-Seq_THP-1_Human1.92054920
26SPI1_23127762_ChIP-Seq_K562_Human1.90977086
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84520607
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83870892
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.82662368
30MAF_26560356_Chip-Seq_TH1_Human1.81663363
31SCL_19346495_ChIP-Seq_HPC-7_Human1.78559002
32MYB_26560356_Chip-Seq_TH2_Human1.77849406
33PU_27001747_Chip-Seq_BMDM_Mouse1.72100997
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65121926
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65047007
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64160351
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63516166
38RUNX_20019798_ChIP-Seq_JUKART_Human1.62831964
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59029519
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58971219
41* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57681062
42MYB_26560356_Chip-Seq_TH1_Human1.56721612
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56250903
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54343789
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51562720
46GATA1_22025678_ChIP-Seq_K562_Human1.50978653
47VDR_24787735_ChIP-Seq_THP-1_Human1.39323381
48UTX_26944678_Chip-Seq_JUKART_Human1.37040617
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36954148
50MYC_22102868_ChIP-Seq_BL_Human1.34995012
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34840566
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32576306
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30363819
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29246025
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29112152
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29004312
57TCF7_22412390_ChIP-Seq_EML_Mouse1.27008717
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22757439
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22379655
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21054140
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.20412198
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20298470
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17550334
64* GATA3_27048872_Chip-Seq_THYMUS_Human1.15283026
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08290312
66* GATA3_26560356_Chip-Seq_TH2_Human1.08210683
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06221440
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.03324664
69MAF_26560356_Chip-Seq_TH2_Human1.03257165
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01667277
71GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99318780
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97998909
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96705389
74KDM2B_26808549_Chip-Seq_JURKAT_Human0.96539377
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95006114
76KDM2B_26808549_Chip-Seq_DND41_Human0.94586411
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94009488
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.91120771
79E2F7_22180533_ChIP-Seq_HELA_Human0.90255002
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.89850473
81IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89359283
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88773395
83SPI1_20517297_ChIP-Seq_HL60_Human0.88209486
84GATA1_19941826_ChIP-Seq_K562_Human0.87221691
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85460234
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85228488
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81807567
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81314543
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81049256
90TFEB_21752829_ChIP-Seq_HELA_Human0.80465258
91GATA2_19941826_ChIP-Seq_K562_Human0.80153350
92* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79646576
93EGR1_19032775_ChIP-ChIP_M12_Human0.78223333
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78145114
95LXR_22292898_ChIP-Seq_THP-1_Human0.77578765
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76407047
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74227259
98STAT1_20625510_ChIP-Seq_HELA_Human0.73789540
99* BCL6_27268052_Chip-Seq_Bcells_Human0.69075972
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68638215
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67105158
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66074287
103* BCOR_27268052_Chip-Seq_Bcells_Human0.65307101
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.61320230
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60496068
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.60065507
107NCOR1_26117541_ChIP-Seq_K562_Human0.59264373
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.59165162
109P300_27268052_Chip-Seq_Bcells_Human0.59118991
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58815876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.59791612
2MP0003303_peritoneal_inflammation4.25426455
3MP0003436_decreased_susceptibility_to3.95200508
4MP0009785_altered_susceptibility_to3.75073430
5* MP0002419_abnormal_innate_immunity3.24405963
6MP0002148_abnormal_hypersensitivity_rea3.13185751
7MP0005000_abnormal_immune_tolerance3.12978085
8MP0006082_CNS_inflammation3.11508974
9MP0005025_abnormal_response_to2.97795713
10* MP0001790_abnormal_immune_system2.89913226
11* MP0005387_immune_system_phenotype2.89913226
12MP0003724_increased_susceptibility_to2.84249760
13MP0000685_abnormal_immune_system2.82111624
14MP0001800_abnormal_humoral_immune2.80864817
15* MP0002452_abnormal_antigen_presenting2.80236551
16MP0005058_abnormal_lysosome_morphology2.72436454
17* MP0002723_abnormal_immune_serum2.55491423
18MP0004510_myositis2.52284408
19MP0005671_abnormal_response_to2.48863016
20* MP0001819_abnormal_immune_cell2.35241045
21MP0009278_abnormal_bone_marrow2.35227598
22* MP0002420_abnormal_adaptive_immunity2.31974339
23MP0001533_abnormal_skeleton_physiology2.22969210
24MP0005464_abnormal_platelet_physiology2.12829478
25MP0004947_skin_inflammation1.99010220
26MP0003191_abnormal_cellular_cholesterol1.98695676
27MP0003172_abnormal_lysosome_physiology1.98065353
28* MP0001845_abnormal_inflammatory_respons1.93179903
29* MP0002405_respiratory_system_inflammati1.85720725
30MP0001853_heart_inflammation1.82985632
31MP0003075_altered_response_to1.80789011
32MP0000343_altered_response_to1.80228135
33MP0009764_decreased_sensitivity_to1.78760113
34MP0010155_abnormal_intestine_physiology1.73819604
35* MP0000716_abnormal_immune_system1.69578327
36MP0003183_abnormal_peptide_metabolism1.69484765
37* MP0008469_abnormal_protein_level1.69239011
38MP0009840_abnormal_foam_cell1.69030290
39MP0003448_altered_tumor_morphology1.63592408
40MP0002006_tumorigenesis1.60895682
41* MP0002398_abnormal_bone_marrow1.59110084
42MP0005167_abnormal_blood-brain_barrier1.57336066
43MP0003300_gastrointestinal_ulcer1.51615405
44MP0005397_hematopoietic_system_phenotyp1.50927032
45MP0001545_abnormal_hematopoietic_system1.50927032
46* MP0000689_abnormal_spleen_morphology1.43171479
47* MP0002429_abnormal_blood_cell1.37659581
48MP0002277_abnormal_respiratory_mucosa1.34836423
49MP0009333_abnormal_splenocyte_physiolog1.34727327
50MP0000858_altered_metastatic_potential1.33869237
51MP0002166_altered_tumor_susceptibility1.33465365
52MP0005166_decreased_susceptibility_to1.31317451
53MP0002998_abnormal_bone_remodeling1.30699655
54MP0005310_abnormal_salivary_gland1.29911664
55MP0002132_abnormal_respiratory_system1.29651298
56MP0003806_abnormal_nucleotide_metabolis1.26319186
57* MP0002722_abnormal_immune_system1.23205712
58MP0005076_abnormal_cell_differentiation1.22679813
59MP0010307_abnormal_tumor_latency1.19270290
60MP0000604_amyloidosis1.18132809
61MP0008004_abnormal_stomach_pH1.16963179
62MP0005164_abnormal_response_to1.13825033
63MP0002138_abnormal_hepatobiliary_system1.06869394
64MP0003566_abnormal_cell_adhesion1.04248162
65MP0002933_joint_inflammation1.03048457
66MP0001873_stomach_inflammation1.00394051
67MP0004782_abnormal_surfactant_physiolog1.00366974
68MP0005390_skeleton_phenotype0.99780873
69MP0003690_abnormal_glial_cell0.99576516
70MP0001851_eye_inflammation0.99244021
71MP0004858_abnormal_nervous_system0.96857974
72MP0009763_increased_sensitivity_to0.96569984
73MP0003828_pulmonary_edema0.96283119
74MP0000465_gastrointestinal_hemorrhage0.95406725
75MP0004381_abnormal_hair_follicle0.89126754
76MP0003453_abnormal_keratinocyte_physiol0.88374635
77MP0008260_abnormal_autophagy0.88108896
78MP0005023_abnormal_wound_healing0.86379872
79MP0010352_gastrointestinal_tract_polyps0.85866432
80MP0003091_abnormal_cell_migration0.84695540
81MP0003186_abnormal_redox_activity0.82156826
82MP0000569_abnormal_digit_pigmentation0.80455001
83MP0004808_abnormal_hematopoietic_stem0.80082402
84MP0000249_abnormal_blood_vessel0.78842711
85MP0004883_abnormal_blood_vessel0.77606709
86MP0009765_abnormal_xenobiotic_induced0.77477595
87MP0000490_abnormal_crypts_of0.75763969
88MP0008874_decreased_physiological_sensi0.71312383
89MP0000767_abnormal_smooth_muscle0.68425863
90MP0000920_abnormal_myelination0.66849631
91MP0006054_spinal_hemorrhage0.66323311
92MP0002396_abnormal_hematopoietic_system0.66083185
93MP0003763_abnormal_thymus_physiology0.65724226
94MP0002136_abnormal_kidney_physiology0.65264695
95MP0001663_abnormal_digestive_system0.62809294
96MP0003656_abnormal_erythrocyte_physiolo0.61889448
97MP0002332_abnormal_exercise_endurance0.61349757
98MP0002254_reproductive_system_inflammat0.61114462
99MP0000371_diluted_coat_color0.59882984
100MP0000015_abnormal_ear_pigmentation0.59697746
101MP0003329_amyloid_beta_deposits0.59152472
102MP0003705_abnormal_hypodermis_morpholog0.58760869
103MP0005174_abnormal_tail_pigmentation0.58268570
104MP0005319_abnormal_enzyme/_coenzyme0.58041134
105MP0003221_abnormal_cardiomyocyte_apopto0.57841314
106* MP0003795_abnormal_bone_structure0.57656067
107MP0005451_abnormal_body_composition0.56748857
108MP0000609_abnormal_liver_physiology0.55386874
109MP0003866_abnormal_defecation0.55380893
110MP0003045_fibrosis0.55117535
111MP0008873_increased_physiological_sensi0.52449052
112* MP0000703_abnormal_thymus_morphology0.51031913
113MP0005075_abnormal_melanosome_morpholog0.49681497
114MP0005381_digestive/alimentary_phenotyp0.46256887

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.80147123
2Eczematoid dermatitis (HP:0000976)7.18716928
3Recurrent bacterial skin infections (HP:0005406)7.11251419
4Recurrent gram-negative bacterial infections (HP:0005420)6.41421018
5Abnormality of macrophages (HP:0004311)5.26395035
6Mediastinal lymphadenopathy (HP:0100721)5.05699606
7Systemic lupus erythematosus (HP:0002725)4.56997475
8Obstructive lung disease (HP:0006536)4.47220201
9Chronic obstructive pulmonary disease (HP:0006510)4.47220201
10Recurrent skin infections (HP:0001581)4.25785859
11Elevated erythrocyte sedimentation rate (HP:0003565)4.21665753
12Gingivitis (HP:0000230)4.20364702
13Autoimmune thrombocytopenia (HP:0001973)4.17002707
14Increased cerebral lipofuscin (HP:0011813)4.12520737
15Myositis (HP:0100614)3.95565829
16Recurrent fungal infections (HP:0002841)3.90708363
17Vacuolated lymphocytes (HP:0001922)3.84803556
18Cellulitis (HP:0100658)3.83846452
19Stomatitis (HP:0010280)3.83495843
20Vasculitis (HP:0002633)3.80348187
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.77977380
22Orchitis (HP:0100796)3.68046070
23Recurrent viral infections (HP:0004429)3.55723626
24Keratoconjunctivitis (HP:0001096)3.43521562
25Glomerulonephritis (HP:0000099)3.40632138
26Encephalitis (HP:0002383)3.39520377
27Interstitial pulmonary disease (HP:0006530)3.34385893
28Abnormality of glycolipid metabolism (HP:0010969)3.30848334
29Abnormality of liposaccharide metabolism (HP:0010968)3.30848334
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.30848334
31Hematochezia (HP:0002573)3.26368467
32Chronic otitis media (HP:0000389)3.24048099
33Meningitis (HP:0001287)3.20526976
34Optic neuritis (HP:0100653)3.19537168
35Retrobulbar optic neuritis (HP:0100654)3.19537168
36Urticaria (HP:0001025)3.17859387
37Pustule (HP:0200039)3.15007635
38Spontaneous hematomas (HP:0007420)2.93356170
39Chest pain (HP:0100749)2.89751736
40Periodontitis (HP:0000704)2.89530538
41T lymphocytopenia (HP:0005403)2.86906329
42Colitis (HP:0002583)2.86537632
43Axonal loss (HP:0003447)2.85414147
44Dysostosis multiplex (HP:0000943)2.84911033
45Episodic fever (HP:0001954)2.84381896
46Basal ganglia calcification (HP:0002135)2.84190976
47Prolonged bleeding time (HP:0003010)2.81870968
48Recurrent pneumonia (HP:0006532)2.81103684
49Osteomyelitis (HP:0002754)2.80962778
50Disinhibition (HP:0000734)2.75446682
51Abnormality of T cell number (HP:0011839)2.72599638
52Pulmonary infiltrates (HP:0002113)2.70661619
53Nephritis (HP:0000123)2.68068567
54Anorexia (HP:0002039)2.67078874
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66509230
56Recurrent cutaneous fungal infections (HP:0011370)2.64034025
57Chronic mucocutaneous candidiasis (HP:0002728)2.64034025
58Gastrointestinal stroma tumor (HP:0100723)2.61856698
59Inflammation of the large intestine (HP:0002037)2.60836598
60Thick nail (HP:0001805)2.58528604
61Pulmonary embolism (HP:0002204)2.57710733
62Loss of speech (HP:0002371)2.56798238
63Increased IgM level (HP:0003496)2.55441804
64Hypochromic microcytic anemia (HP:0004840)2.55149097
65Epistaxis (HP:0000421)2.52145253
66Peritonitis (HP:0002586)2.51528339
67Gangrene (HP:0100758)2.49313343
68Recurrent lower respiratory tract infections (HP:0002783)2.48825436
69Prostate neoplasm (HP:0100787)2.47804177
70Abnormality of the nasal mucosa (HP:0000433)2.46246350
71Emphysema (HP:0002097)2.46078602
72Purpura (HP:0000979)2.46062937
73Hepatosplenomegaly (HP:0001433)2.45584877
74Gastrointestinal inflammation (HP:0004386)2.45094170
75Hemoptysis (HP:0002105)2.45083641
76Hypochromic anemia (HP:0001931)2.40779594
77Nasal polyposis (HP:0100582)2.38166847
78Tetraparesis (HP:0002273)2.38040246
79Agnosia (HP:0010524)2.36159952
80Abnormality of complement system (HP:0005339)2.35632453
81Recurrent bronchitis (HP:0002837)2.34824303
82Restrictive lung disease (HP:0002091)2.33842853
83Leukocytosis (HP:0001974)2.32952071
84Gingival bleeding (HP:0000225)2.27433820
85Abnormality of T cells (HP:0002843)2.23536506
86Hypergammaglobulinemia (HP:0010702)2.22773634
87Urinary glycosaminoglycan excretion (HP:0003541)2.22681348
88Mucopolysacchariduria (HP:0008155)2.22681348
89Myocardial infarction (HP:0001658)2.21035065
90Skin ulcer (HP:0200042)2.20878993
91Arterial thrombosis (HP:0004420)2.19349914
92Abnormality of iron homeostasis (HP:0011031)2.15573722
93IgM deficiency (HP:0002850)2.14714542
94Granulocytopenia (HP:0001913)2.14095999
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13750443
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.10821723
97Lymphopenia (HP:0001888)2.10392322
98Glomerulopathy (HP:0100820)2.10370139
99Vertigo (HP:0002321)2.09541886
100Polyneuropathy (HP:0001271)2.09515194
101Abnormality of the endocardium (HP:0004306)2.08857145
102Petechiae (HP:0000967)2.07456390
103Abnormality of polysaccharide metabolism (HP:0011012)2.07256973
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07256973
105Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07256973
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.06577387
107Osteolytic defects of the hand bones (HP:0009699)2.06577387
108Panhypogammaglobulinemia (HP:0003139)2.06444099
109Sepsis (HP:0100806)2.06111003
110Abnormality of the peritoneum (HP:0002585)2.03561285
111Premature loss of primary teeth (HP:0006323)2.02866213
112Acne (HP:0001061)2.01193091
113Agammaglobulinemia (HP:0004432)2.00963321
114Keratoconjunctivitis sicca (HP:0001097)2.00636405
115Amyloidosis (HP:0011034)1.99722383
116Mutism (HP:0002300)1.98779866
117Poor head control (HP:0002421)1.97536308
118Pathologic fracture (HP:0002756)1.96249312
119Gastrointestinal infarctions (HP:0005244)1.95631676
120Abnormality of the pericardium (HP:0001697)1.94076255
121Abnormality of the pleura (HP:0002103)1.93169201
122Arthralgia (HP:0002829)1.92557613
123Malnutrition (HP:0004395)1.91864351
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.91848804
125Increased IgE level (HP:0003212)1.91633060
126Microcytic anemia (HP:0001935)1.91589096
127Complement deficiency (HP:0004431)1.89497415
128Keratitis (HP:0000491)1.89085139
129Eosinophilia (HP:0001880)1.88125741
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88037424
131Increased serum ferritin (HP:0003281)1.87484099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.43173692
2BLK3.86601253
3MAP3K143.66811326
4MAP4K13.64558628
5IRAK43.59866193
6TYK23.50050565
7TBK13.46334825
8ERN13.03581688
9IRAK32.88738064
10IKBKE2.58562250
11KIT2.23413064
12PRPF4B2.18101793
13IKBKB2.06183176
14CSF1R2.05553996
15JAK12.02868677
16FGR2.01002828
17TAOK11.95967198
18TNK21.95909871
19TGFBR21.94729513
20JAK31.93595298
21PBK1.81459133
22STK101.80108754
23MAP3K131.77294483
24* CSK1.63839377
25EPHB11.56110602
26ZAP701.54294989
27SYK1.51237337
28BTK1.47718053
29FES1.41744895
30MATK1.38807578
31TAOK21.36999139
32TXK1.30395132
33CLK11.27349633
34* HCK1.26926524
35SIK31.24355786
36RPS6KA41.20372631
37TEC1.16765496
38* LYN1.16630411
39CHUK1.16370036
40LCK1.08020786
41GRK61.05815300
42JAK21.05208592
43PIM11.02599253
44IRAK11.01621777
45FGFR41.00751206
46MAP3K100.99879414
47MAP2K30.98471915
48IRAK20.97606346
49MARK30.95754025
50CDC42BPA0.94119533
51LRRK20.93721241
52FGFR30.90307189
53RIPK10.89037308
54MARK20.85557650
55PIM20.85014731
56PTK60.78039658
57MAP3K110.77556194
58MST40.76279275
59GRK70.76056342
60BMX0.74432956
61EGFR0.72645556
62STK40.71042804
63PRKD20.69948497
64TAOK30.68987980
65MAP3K60.67129312
66CAMK1D0.66168930
67MOS0.65421060
68MAP3K50.64926849
69ABL10.63105846
70CDK190.63012483
71TTN0.62777710
72PRKCD0.62591068
73PAK40.61601461
74NEK90.60096373
75TRPM70.59699256
76ITK0.57316065
77SIK20.56574492
78YES10.56405389
79EIF2AK20.55730505
80TRIB30.55528201
81MAPK120.53414442
82CAMKK20.53274422
83MAP3K30.52832488
84DAPK20.52737830
85KSR20.52476003
86BMPR20.51407828
87MAPK70.51282288
88ALK0.49664216
89TESK10.49570099
90ABL20.49155804
91DYRK1B0.48489549
92MAP3K20.47854216
93PRKG20.46102339
94PDK10.45893366
95CDK120.45672505
96ARAF0.45072638
97MAP2K60.45003242
98MAPKAPK20.44344184
99KDR0.44097420
100MAP2K40.43869313
101PTK2B0.43778427
102NME20.43375368
103HIPK20.42725326
104SGK30.42714838
105STK110.41724179
106PIK3CG0.41185343
107MAP3K80.41031906
108RPS6KA60.40076527
109STK30.39835630
110SMG10.39608422
111PDPK10.39475449
112MAP3K10.39283734
113STK240.39159603
114PKN20.37324497
115KSR10.35636306
116SIK10.34710726
117MAP3K70.34343590
118ACVR1B0.33453082
119* FYN0.33011518
120PRKCQ0.32566951
121MAPK40.31001099
122RET0.29578865
123DDR20.29549249
124MAP3K90.29369867
125RPS6KC10.29247458
126RPS6KL10.29247458
127EPHA30.29163637
128FLT30.25479181
129TESK20.23745820
130ERBB30.23690002
131* INSR0.21055495
132MST1R0.20631247

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.71618064
2Staphylococcus aureus infection_Homo sapiens_hsa051503.68168853
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.92207601
4Osteoclast differentiation_Homo sapiens_hsa043802.69840954
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.65200118
6Pertussis_Homo sapiens_hsa051332.47425495
7Legionellosis_Homo sapiens_hsa051342.43560986
8B cell receptor signaling pathway_Homo sapiens_hsa046622.31383506
9Graft-versus-host disease_Homo sapiens_hsa053322.30203209
10Tuberculosis_Homo sapiens_hsa051522.29978543
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27685719
12Malaria_Homo sapiens_hsa051442.22041702
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18075745
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12248316
15Measles_Homo sapiens_hsa051622.03561365
16Influenza A_Homo sapiens_hsa051641.93981277
17Lysosome_Homo sapiens_hsa041421.88478482
18TNF signaling pathway_Homo sapiens_hsa046681.86954673
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79074440
20Asthma_Homo sapiens_hsa053101.78918916
21Salmonella infection_Homo sapiens_hsa051321.77328484
22African trypanosomiasis_Homo sapiens_hsa051431.73602667
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.69888005
24Allograft rejection_Homo sapiens_hsa053301.69366669
25Antigen processing and presentation_Homo sapiens_hsa046121.67654191
26Hematopoietic cell lineage_Homo sapiens_hsa046401.66591026
27Toxoplasmosis_Homo sapiens_hsa051451.66476509
28Herpes simplex infection_Homo sapiens_hsa051681.66363970
29Rheumatoid arthritis_Homo sapiens_hsa053231.66262101
30* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63774410
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.57780115
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.57525553
33Phagosome_Homo sapiens_hsa041451.55783681
34Other glycan degradation_Homo sapiens_hsa005111.54630385
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45928020
36Shigellosis_Homo sapiens_hsa051311.45262139
37* Chemokine signaling pathway_Homo sapiens_hsa040621.43016096
38Apoptosis_Homo sapiens_hsa042101.35994726
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28821093
40Type I diabetes mellitus_Homo sapiens_hsa049401.28142997
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.23931947
42Hepatitis C_Homo sapiens_hsa051601.16535459
43Primary immunodeficiency_Homo sapiens_hsa053401.15880919
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15720595
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.15133863
46Hepatitis B_Homo sapiens_hsa051611.14359506
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09393316
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04315858
49Amoebiasis_Homo sapiens_hsa051460.93861596
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90214708
51Viral myocarditis_Homo sapiens_hsa054160.86878828
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85704685
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85034959
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84409542
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83904289
56Acute myeloid leukemia_Homo sapiens_hsa052210.82681361
57Complement and coagulation cascades_Homo sapiens_hsa046100.78959340
58T cell receptor signaling pathway_Homo sapiens_hsa046600.78463593
59Prion diseases_Homo sapiens_hsa050200.77225520
60Epstein-Barr virus infection_Homo sapiens_hsa051690.77164981
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73385774
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.72487157
63Platelet activation_Homo sapiens_hsa046110.72373623
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70383932
65Chronic myeloid leukemia_Homo sapiens_hsa052200.69945193
66Pancreatic cancer_Homo sapiens_hsa052120.68727016
67Caffeine metabolism_Homo sapiens_hsa002320.62337910
68Collecting duct acid secretion_Homo sapiens_hsa049660.54398809
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.54349866
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.53437149
71Viral carcinogenesis_Homo sapiens_hsa052030.50180692
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.49565997
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47439530
74VEGF signaling pathway_Homo sapiens_hsa043700.47416498
75Prolactin signaling pathway_Homo sapiens_hsa049170.47392722
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46727330
77Autoimmune thyroid disease_Homo sapiens_hsa053200.46550625
78GnRH signaling pathway_Homo sapiens_hsa049120.46147899
79HIF-1 signaling pathway_Homo sapiens_hsa040660.46111683
80Small cell lung cancer_Homo sapiens_hsa052220.45957695
81Bladder cancer_Homo sapiens_hsa052190.45001139
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42848449
83Type II diabetes mellitus_Homo sapiens_hsa049300.41478660
84Endocytosis_Homo sapiens_hsa041440.40091573
85Notch signaling pathway_Homo sapiens_hsa043300.37811380
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36790343
87Insulin resistance_Homo sapiens_hsa049310.36561661
88Mineral absorption_Homo sapiens_hsa049780.35246673
89Endometrial cancer_Homo sapiens_hsa052130.34608085
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33909926
91Choline metabolism in cancer_Homo sapiens_hsa052310.32764142
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31897143
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29575103
94Rap1 signaling pathway_Homo sapiens_hsa040150.28028844
95Proteoglycans in cancer_Homo sapiens_hsa052050.27747557
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27190271
97HTLV-I infection_Homo sapiens_hsa051660.26128842
98Dorso-ventral axis formation_Homo sapiens_hsa043200.24765429
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23876424
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23033669
101Regulation of autophagy_Homo sapiens_hsa041400.22950749
102Systemic lupus erythematosus_Homo sapiens_hsa053220.22124651
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20782434
104FoxO signaling pathway_Homo sapiens_hsa040680.19439564
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18069159
106MAPK signaling pathway_Homo sapiens_hsa040100.17735055
107Non-small cell lung cancer_Homo sapiens_hsa052230.16945345
108Renal cell carcinoma_Homo sapiens_hsa052110.15376425
109MicroRNAs in cancer_Homo sapiens_hsa052060.15365565
110Adherens junction_Homo sapiens_hsa045200.13619298
111Pentose phosphate pathway_Homo sapiens_hsa000300.13591419
112mTOR signaling pathway_Homo sapiens_hsa041500.12125226
113Renin-angiotensin system_Homo sapiens_hsa046140.11861908

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