HCLS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.94852743
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.90915366
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.90915366
4antigen processing and presentation of endogenous antigen (GO:0019883)5.70667947
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36286811
6regulation of B cell receptor signaling pathway (GO:0050855)5.04341950
7positive regulation by symbiont of host defense response (GO:0052509)4.71252168
8modulation by symbiont of host defense response (GO:0052031)4.71252168
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.71252168
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.71252168
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.71252168
12modulation by symbiont of host immune response (GO:0052553)4.71252168
13positive regulation of B cell differentiation (GO:0045579)4.62741049
14detection of other organism (GO:0098543)4.45145647
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40885127
16regulation of gamma-delta T cell differentiation (GO:0045586)4.33018188
17regulation of interferon-beta biosynthetic process (GO:0045357)4.31261230
18B cell receptor signaling pathway (GO:0050853)4.30706200
19detection of bacterium (GO:0016045)4.30066572
20leukocyte aggregation (GO:0070486)4.25034053
21regulation of B cell differentiation (GO:0045577)4.23801350
22regulation of gamma-delta T cell activation (GO:0046643)4.19330664
23immunoglobulin mediated immune response (GO:0016064)4.16631016
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.02710802
25negative regulation of cell killing (GO:0031342)3.88489448
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88489448
27negative regulation of T cell mediated immunity (GO:0002710)3.83393207
28detection of external biotic stimulus (GO:0098581)3.79852394
29neutrophil activation involved in immune response (GO:0002283)3.79556018
30respiratory burst (GO:0045730)3.79088947
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75994287
32positive regulation of interferon-alpha production (GO:0032727)3.71182988
33response to peptidoglycan (GO:0032494)3.69386646
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68825787
35negative regulation of leukocyte mediated immunity (GO:0002704)3.64433095
36regulation of interferon-alpha production (GO:0032647)3.58536841
37detection of molecule of bacterial origin (GO:0032490)3.57839949
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52664650
39microglial cell activation (GO:0001774)3.52207522
40macrophage activation involved in immune response (GO:0002281)3.51926530
41positive regulation of antigen processing and presentation (GO:0002579)3.50212407
42antigen processing and presentation via MHC class Ib (GO:0002475)3.50208066
43regulation of T cell tolerance induction (GO:0002664)3.47739700
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.47665741
45cellular extravasation (GO:0045123)3.46403357
46positive thymic T cell selection (GO:0045059)3.45060666
47T cell migration (GO:0072678)3.41776444
48tolerance induction (GO:0002507)3.38129797
49B cell mediated immunity (GO:0019724)3.36794455
50detection of biotic stimulus (GO:0009595)3.34718374
51negative thymic T cell selection (GO:0045060)3.34570147
52regulation of tolerance induction (GO:0002643)3.34010176
53response to type I interferon (GO:0034340)3.33425976
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.32517336
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31249074
56cellular response to type I interferon (GO:0071357)3.30369711
57type I interferon signaling pathway (GO:0060337)3.30369711
58negative T cell selection (GO:0043383)3.30130766
59defense response to protozoan (GO:0042832)3.29134650
60negative regulation of phagocytosis (GO:0050765)3.26911242
61response to interleukin-15 (GO:0070672)3.23033109
62interferon-gamma-mediated signaling pathway (GO:0060333)3.22953166
63response to protozoan (GO:0001562)3.22263240
64negative regulation of interleukin-12 production (GO:0032695)3.20757875
65macrophage activation (GO:0042116)3.20574480
66positive regulation of mast cell activation (GO:0033005)3.19820053
67myeloid dendritic cell activation (GO:0001773)3.19365346
68mature B cell differentiation (GO:0002335)3.19136520
69response to muramyl dipeptide (GO:0032495)3.19040167
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18306832
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17723322
72response to host immune response (GO:0052572)3.17723322
73myeloid cell activation involved in immune response (GO:0002275)3.16086573
74neutrophil activation (GO:0042119)3.15304841
75regulation of T cell mediated cytotoxicity (GO:0001914)3.13943041
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13857670
77mast cell activation (GO:0045576)3.12123100
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09177039
79regulation of natural killer cell mediated immunity (GO:0002715)3.09177039
80neutrophil mediated immunity (GO:0002446)3.09088631
81regulation of mast cell activation involved in immune response (GO:0033006)3.08039781
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07692308
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06246586
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05755660
85regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05567236
86regulation of regulatory T cell differentiation (GO:0045589)3.04971381
87leukocyte degranulation (GO:0043299)3.04686855
88NIK/NF-kappaB signaling (GO:0038061)3.03575402
89regulation of mast cell activation (GO:0033003)3.01613837
90granulocyte activation (GO:0036230)3.00672423
91myeloid dendritic cell differentiation (GO:0043011)2.99878882
92production of molecular mediator involved in inflammatory response (GO:0002532)2.98736928
93response to host (GO:0075136)2.98543443
94response to host defenses (GO:0052200)2.98543443
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98543443
96leukocyte cell-cell adhesion (GO:0007159)2.98434510
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97193213
98negative regulation of innate immune response (GO:0045824)2.96618640
99regulation of antigen processing and presentation (GO:0002577)2.96572869
100activated T cell proliferation (GO:0050798)2.96233265
101antigen receptor-mediated signaling pathway (GO:0050851)2.93321912
102T cell homeostasis (GO:0043029)2.93277482
103regulation of leukocyte degranulation (GO:0043300)2.91879887
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88940126
105interferon-gamma production (GO:0032609)2.88862111
106regulation of alpha-beta T cell proliferation (GO:0046640)2.87065216
107thymic T cell selection (GO:0045061)2.86634131
108cellular response to zinc ion (GO:0071294)2.86618755
109lymphocyte homeostasis (GO:0002260)2.83701784
110negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83131214
111germinal center formation (GO:0002467)2.81645670
112pinocytosis (GO:0006907)2.80572775
113cellular response to interleukin-15 (GO:0071350)2.80172043
114actin nucleation (GO:0045010)2.79869885
115positive regulation of interferon-beta production (GO:0032728)2.78494421
116mature B cell differentiation involved in immune response (GO:0002313)2.75738232
117T cell selection (GO:0045058)2.75556465
118regulation of T cell receptor signaling pathway (GO:0050856)2.75457784
119B cell homeostasis (GO:0001782)2.75040624
120lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70786743
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69880628
122negative regulation of erythrocyte differentiation (GO:0045647)2.68345792
123cellular response to interferon-beta (GO:0035458)2.67083712
124positive T cell selection (GO:0043368)2.65395398
125negative regulation of B cell proliferation (GO:0030889)2.65308886
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63522257
127positive regulation of interleukin-2 production (GO:0032743)2.63480572
128T cell costimulation (GO:0031295)2.63437447
129positive regulation of cytokine biosynthetic process (GO:0042108)2.62801400
130regulation of mast cell degranulation (GO:0043304)2.61772051
131regulation of response to interferon-gamma (GO:0060330)2.61717459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.04531945
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.44668106
3E2F7_22180533_ChIP-Seq_HELA_Human4.25108329
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93995859
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74888423
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69441410
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60280870
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.53795127
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.15465148
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14091715
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.11126059
12MYC_22102868_ChIP-Seq_BL_Human3.10574273
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03642668
14VDR_21846776_ChIP-Seq_THP-1_Human2.86597413
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84498320
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83580854
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81897805
18SCL_19346495_ChIP-Seq_HPC-7_Human2.70909675
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57568511
20* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49580489
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46576791
22MYB_26560356_Chip-Seq_TH2_Human2.45658754
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45530700
24* SPI1_23547873_ChIP-Seq_NB4_Human2.44932359
25MAF_26560356_Chip-Seq_TH1_Human2.37372440
26RUNX_20019798_ChIP-Seq_JUKART_Human2.22900927
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22282935
28VDR_24763502_ChIP-Seq_THP-1_Human2.21541237
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20638599
30MYB_26560356_Chip-Seq_TH1_Human2.14220644
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13759648
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13746841
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.10983849
34* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10787139
35UTX_26944678_Chip-Seq_JUKART_Human2.08723930
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93474842
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89908139
38TCF7_22412390_ChIP-Seq_EML_Mouse1.86373939
39SPI1_23127762_ChIP-Seq_K562_Human1.82347052
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73047107
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72572688
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.72018457
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70467804
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69881614
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65816600
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64506522
47MAF_26560356_Chip-Seq_TH2_Human1.55462444
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54287987
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54114445
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47226389
51GATA3_27048872_Chip-Seq_THYMUS_Human1.46489077
52PU_27001747_Chip-Seq_BMDM_Mouse1.46471688
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.44487765
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43853349
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43166533
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.42626739
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37137475
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36985311
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36140314
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35600773
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34787484
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32416737
63KDM2B_26808549_Chip-Seq_DND41_Human1.30314902
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.28337869
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25409143
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24570991
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23862483
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23522451
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21647657
70* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21419375
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20722143
72CIITA_25753668_ChIP-Seq_RAJI_Human1.19829370
73GATA1_22025678_ChIP-Seq_K562_Human1.18745979
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16171927
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13004230
76GATA1_19941826_ChIP-Seq_K562_Human1.12690070
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11041710
78GATA3_26560356_Chip-Seq_TH2_Human1.08820947
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07651587
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06995918
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.06353792
82BCL6_27268052_Chip-Seq_Bcells_Human1.06324307
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04541553
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03916913
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03507954
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01931572
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00753488
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00574997
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00557653
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00439341
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.99952764
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98310714
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98188232
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96643166
95VDR_23849224_ChIP-Seq_CD4+_Human0.95625541
96BCOR_27268052_Chip-Seq_Bcells_Human0.93774969
97TFEB_21752829_ChIP-Seq_HELA_Human0.93574894
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91670895
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.90419254
100VDR_24787735_ChIP-Seq_THP-1_Human0.88477522
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87286174
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87149738
103GATA2_19941826_ChIP-Seq_K562_Human0.86202523
104NCOR1_26117541_ChIP-Seq_K562_Human0.85580216
105FOXP3_21729870_ChIP-Seq_TREG_Human0.84417713
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.82877940
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.82770389
108SPI1_20517297_ChIP-Seq_HL60_Human0.78842995
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78781580
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78330392
111LXR_22292898_ChIP-Seq_THP-1_Human0.77839365
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76238566
113RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76235984
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75499399
115E2F1_21310950_ChIP-Seq_MCF-7_Human0.74031862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40585521
2MP0003303_peritoneal_inflammation3.53883800
3MP0003436_decreased_susceptibility_to3.27463748
4MP0000685_abnormal_immune_system3.25972158
5* MP0001800_abnormal_humoral_immune3.21311159
6MP0005671_abnormal_response_to3.19512567
7MP0001790_abnormal_immune_system3.16967894
8MP0005387_immune_system_phenotype3.16967894
9MP0009785_altered_susceptibility_to3.07171657
10MP0005000_abnormal_immune_tolerance3.02777029
11* MP0002452_abnormal_antigen_presenting2.92293831
12MP0005025_abnormal_response_to2.77664415
13MP0002723_abnormal_immune_serum2.77263126
14MP0002419_abnormal_innate_immunity2.75493720
15* MP0002420_abnormal_adaptive_immunity2.67931858
16* MP0001819_abnormal_immune_cell2.66019482
17MP0002148_abnormal_hypersensitivity_rea2.50983356
18MP0003763_abnormal_thymus_physiology2.44180654
19* MP0002398_abnormal_bone_marrow2.41200774
20MP0005464_abnormal_platelet_physiology2.38789925
21MP0006082_CNS_inflammation2.37773730
22MP0002396_abnormal_hematopoietic_system2.30644292
23MP0003300_gastrointestinal_ulcer2.22340229
24* MP0000716_abnormal_immune_system2.21805630
25MP0002405_respiratory_system_inflammati2.20139668
26MP0000689_abnormal_spleen_morphology2.11612608
27MP0009333_abnormal_splenocyte_physiolog2.05114404
28MP0004510_myositis2.03406203
29MP0003724_increased_susceptibility_to2.02795384
30MP0005058_abnormal_lysosome_morphology2.01512398
31MP0002722_abnormal_immune_system1.98454579
32MP0002166_altered_tumor_susceptibility1.98030294
33MP0010155_abnormal_intestine_physiology1.90557445
34MP0009278_abnormal_bone_marrow1.89106291
35* MP0002429_abnormal_blood_cell1.88365416
36MP0001845_abnormal_inflammatory_respons1.87668486
37MP0001853_heart_inflammation1.87111058
38MP0004947_skin_inflammation1.86342565
39MP0004808_abnormal_hematopoietic_stem1.82281749
40MP0001873_stomach_inflammation1.78038230
41MP0005397_hematopoietic_system_phenotyp1.73267361
42MP0001545_abnormal_hematopoietic_system1.73267361
43MP0002006_tumorigenesis1.66730652
44MP0008260_abnormal_autophagy1.65257721
45MP0000465_gastrointestinal_hemorrhage1.64945936
46MP0003172_abnormal_lysosome_physiology1.63216174
47MP0001533_abnormal_skeleton_physiology1.61739879
48MP0000703_abnormal_thymus_morphology1.59742529
49MP0008469_abnormal_protein_level1.47112597
50MP0005310_abnormal_salivary_gland1.42789473
51MP0002933_joint_inflammation1.39254514
52MP0005451_abnormal_body_composition1.38805621
53MP0003866_abnormal_defecation1.35372536
54MP0003191_abnormal_cellular_cholesterol1.35342455
55MP0005174_abnormal_tail_pigmentation1.34836314
56MP0000490_abnormal_crypts_of1.33692543
57MP0003448_altered_tumor_morphology1.33625597
58MP0003183_abnormal_peptide_metabolism1.28349457
59MP0004381_abnormal_hair_follicle1.27859755
60MP0000858_altered_metastatic_potential1.22332222
61MP0009840_abnormal_foam_cell1.17016498
62MP0010307_abnormal_tumor_latency1.16699300
63MP0000343_altered_response_to1.14324203
64MP0004883_abnormal_blood_vessel1.11589029
65MP0009764_decreased_sensitivity_to1.04540129
66MP0001851_eye_inflammation1.03531050
67MP0002277_abnormal_respiratory_mucosa1.00027470
68MP0002019_abnormal_tumor_incidence0.97043490
69MP0003690_abnormal_glial_cell0.95664636
70MP0010352_gastrointestinal_tract_polyps0.91921870
71MP0003075_altered_response_to0.91287762
72MP0002998_abnormal_bone_remodeling0.90559168
73MP0005164_abnormal_response_to0.84149987
74MP0005166_decreased_susceptibility_to0.83224439
75MP0003828_pulmonary_edema0.82952596
76MP0005076_abnormal_cell_differentiation0.82849899
77MP0000015_abnormal_ear_pigmentation0.81537772
78MP0002009_preneoplasia0.81383237
79MP0009763_increased_sensitivity_to0.79381196
80MP0005075_abnormal_melanosome_morpholog0.78945797
81MP0003566_abnormal_cell_adhesion0.77319149
82MP0000604_amyloidosis0.76568594
83MP0003693_abnormal_embryo_hatching0.76362591
84MP0003806_abnormal_nucleotide_metabolis0.75937257
85MP0003045_fibrosis0.75285969
86MP0003656_abnormal_erythrocyte_physiolo0.74761364
87MP0001663_abnormal_digestive_system0.72123159
88MP0008004_abnormal_stomach_pH0.71244345
89MP0005023_abnormal_wound_healing0.70316952
90MP0001986_abnormal_taste_sensitivity0.69109293
91MP0003077_abnormal_cell_cycle0.67842897
92MP0002095_abnormal_skin_pigmentation0.66240954
93MP0000569_abnormal_digit_pigmentation0.65911048
94MP0000249_abnormal_blood_vessel0.65464217
95MP0005390_skeleton_phenotype0.65346197
96MP0010094_abnormal_chromosome_stability0.62322657
97MP0002132_abnormal_respiratory_system0.61533913
98MP0008874_decreased_physiological_sensi0.60954924
99MP0000313_abnormal_cell_death0.59992681
100MP0008057_abnormal_DNA_replication0.59646701
101MP0003795_abnormal_bone_structure0.58533634
102MP0002136_abnormal_kidney_physiology0.57963956
103MP0008873_increased_physiological_sensi0.57469431
104MP0006054_spinal_hemorrhage0.53446083
105MP0000609_abnormal_liver_physiology0.52628873
106MP0000371_diluted_coat_color0.51618142
107MP0002138_abnormal_hepatobiliary_system0.51273702
108MP0008007_abnormal_cellular_replicative0.50389705
109MP0000598_abnormal_liver_morphology0.49762292
110MP0003221_abnormal_cardiomyocyte_apopto0.49148559
111MP0003091_abnormal_cell_migration0.48710394
112MP0002693_abnormal_pancreas_physiology0.48640663
113MP0003453_abnormal_keratinocyte_physiol0.47316676
114MP0000477_abnormal_intestine_morphology0.45782141
115MP0009765_abnormal_xenobiotic_induced0.45064717
116MP0005319_abnormal_enzyme/_coenzyme0.44296764
117MP0005167_abnormal_blood-brain_barrier0.44185363
118MP0004130_abnormal_muscle_cell0.43254033
119MP0000920_abnormal_myelination0.42573217
120MP0005381_digestive/alimentary_phenotyp0.42448472

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.99951569
2Eczematoid dermatitis (HP:0000976)5.60722915
3Recurrent bacterial skin infections (HP:0005406)5.30958540
4Chronic otitis media (HP:0000389)4.48761080
5Recurrent viral infections (HP:0004429)4.46094214
6IgM deficiency (HP:0002850)4.43217255
7Recurrent fungal infections (HP:0002841)4.35085995
8Myositis (HP:0100614)4.33991671
9Cellulitis (HP:0100658)4.22235422
10Elevated erythrocyte sedimentation rate (HP:0003565)4.17198899
11Recurrent gram-negative bacterial infections (HP:0005420)4.13880473
12Abnormality of macrophages (HP:0004311)3.94604082
13Mediastinal lymphadenopathy (HP:0100721)3.91289479
14Meningitis (HP:0001287)3.90442643
15Recurrent bronchitis (HP:0002837)3.89121134
16Gastrointestinal infarctions (HP:0005244)3.82927200
17Chronic obstructive pulmonary disease (HP:0006510)3.75074591
18Obstructive lung disease (HP:0006536)3.75074591
19Recurrent skin infections (HP:0001581)3.74470002
20Agammaglobulinemia (HP:0004432)3.72390422
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.65803872
22Inflammation of the large intestine (HP:0002037)3.55576729
23Panhypogammaglobulinemia (HP:0003139)3.49610272
24Gastrointestinal inflammation (HP:0004386)3.47300170
25Vasculitis (HP:0002633)3.37386521
26Colitis (HP:0002583)3.37197101
27Nasal polyposis (HP:0100582)3.34123762
28Chronic mucocutaneous candidiasis (HP:0002728)3.30540080
29Recurrent cutaneous fungal infections (HP:0011370)3.30540080
30Orchitis (HP:0100796)3.21670350
31Keratoconjunctivitis (HP:0001096)3.20897404
32Stomatitis (HP:0010280)3.20613734
33Spontaneous hematomas (HP:0007420)3.16291765
34Autoimmune thrombocytopenia (HP:0001973)3.14033060
35T lymphocytopenia (HP:0005403)3.11778991
36Pustule (HP:0200039)3.11393973
37Abnormality of T cells (HP:0002843)3.10964488
38Abnormality of the nasal mucosa (HP:0000433)3.10496552
39Thrombocytosis (HP:0001894)3.09282014
40Optic neuritis (HP:0100653)3.08165084
41Retrobulbar optic neuritis (HP:0100654)3.08165084
42Abnormality of T cell number (HP:0011839)3.04981734
43Vacuolated lymphocytes (HP:0001922)3.04397230
44Increased cerebral lipofuscin (HP:0011813)2.99468900
45Abnormality of T cell physiology (HP:0011840)2.95050622
46Interstitial pulmonary disease (HP:0006530)2.94728560
47Increased IgM level (HP:0003496)2.93538321
48Lymphopenia (HP:0001888)2.91286614
49Petechiae (HP:0000967)2.90129253
50Osteomyelitis (HP:0002754)2.89874989
51Gastrointestinal stroma tumor (HP:0100723)2.84851783
52Gingivitis (HP:0000230)2.84673607
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.83990818
54B lymphocytopenia (HP:0010976)2.83382113
55Abnormality of B cell number (HP:0010975)2.83382113
56Papilloma (HP:0012740)2.71512281
57Verrucae (HP:0200043)2.71512281
58Thyroiditis (HP:0100646)2.70147778
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.69628919
60Systemic lupus erythematosus (HP:0002725)2.68568853
61Prolonged bleeding time (HP:0003010)2.67851010
62Autoimmune hemolytic anemia (HP:0001890)2.65718446
63Chronic sinusitis (HP:0011109)2.63503024
64Recurrent sinusitis (HP:0011108)2.61460010
65Pulmonary embolism (HP:0002204)2.60885667
66Increased IgE level (HP:0003212)2.59338555
67Leukocytosis (HP:0001974)2.58332551
68Recurrent pneumonia (HP:0006532)2.58081856
69Pulmonary infiltrates (HP:0002113)2.53868106
70Eosinophilia (HP:0001880)2.52719954
71Arterial thrombosis (HP:0004420)2.51289613
72Encephalitis (HP:0002383)2.50886667
73Hypochromic anemia (HP:0001931)2.50854846
74IgG deficiency (HP:0004315)2.47481367
75Abnormality of liposaccharide metabolism (HP:0010968)2.45472217
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.45472217
77Abnormality of glycolipid metabolism (HP:0010969)2.45472217
78Recurrent lower respiratory tract infections (HP:0002783)2.44486093
79Periodontitis (HP:0000704)2.43955478
80Urticaria (HP:0001025)2.43122445
81Anorexia (HP:0002039)2.42876504
82Epistaxis (HP:0000421)2.41742694
83IgA deficiency (HP:0002720)2.38608574
84Hypochromic microcytic anemia (HP:0004840)2.38214858
85Dysostosis multiplex (HP:0000943)2.37650461
86Gangrene (HP:0100758)2.37084161
87Abnormality of the pleura (HP:0002103)2.36956821
88Episodic fever (HP:0001954)2.35118290
89Hematochezia (HP:0002573)2.34797272
90Hemoptysis (HP:0002105)2.33375052
91Emphysema (HP:0002097)2.33015007
92Granulocytopenia (HP:0001913)2.32662012
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29964455
94Gingival bleeding (HP:0000225)2.29846507
95Sepsis (HP:0100806)2.27112351
96Chest pain (HP:0100749)2.26217279
97Impaired platelet aggregation (HP:0003540)2.22093353
98Abnormal platelet function (HP:0011869)2.22093353
99Skin ulcer (HP:0200042)2.21819295
100Lymphoma (HP:0002665)2.19874028
101Abnormality of eosinophils (HP:0001879)2.18665486
102Abnormality of the prostate (HP:0008775)2.17896273
103Chronic diarrhea (HP:0002028)2.15450733
104Combined immunodeficiency (HP:0005387)2.13449612
105Viral hepatitis (HP:0006562)2.13046133
106Keratoconjunctivitis sicca (HP:0001097)2.12582529
107Purpura (HP:0000979)2.12549328
108Severe combined immunodeficiency (HP:0004430)2.12079104
109Amyloidosis (HP:0011034)2.11333306
110Glomerulopathy (HP:0100820)2.10814871
111Hypergammaglobulinemia (HP:0010702)2.07838104
112Loss of speech (HP:0002371)2.07826220
113Hepatosplenomegaly (HP:0001433)2.07319156
114Bronchitis (HP:0012387)2.06759086
115Microcytic anemia (HP:0001935)2.06632701
116Disinhibition (HP:0000734)2.05645297
117Abnormality of the fingertips (HP:0001211)2.04591095
118Abnormality of the peritoneum (HP:0002585)2.03261786
119Skin rash (HP:0000988)2.02945692
120Restrictive lung disease (HP:0002091)2.02481856
121Agnosia (HP:0010524)2.00348545
122Slow saccadic eye movements (HP:0000514)1.99736567
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98223969
124Increased serum ferritin (HP:0003281)1.98172102
125Basal ganglia calcification (HP:0002135)1.97691714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.26768213
2BLK3.07454686
3KIT2.72927326
4TYK22.71966756
5TXK2.62009837
6TBK12.52475764
7JAK32.41675196
8PRPF4B2.39646154
9IRAK42.38244894
10BTK2.32339682
11ZAP702.23845160
12EEF2K2.22748405
13MAP3K142.16351157
14STK102.13856195
15RIPK42.09514359
16ERN12.06296961
17MAP3K101.95686030
18IKBKE1.94302634
19GRK61.93400286
20* SYK1.89199681
21TGFBR21.82140408
22TEC1.74575937
23JAK11.71976935
24* FES1.66248547
25HCK1.63807821
26ITK1.60135851
27CSK1.59248280
28IKBKB1.56985501
29LRRK21.56942949
30PKN21.56543779
31IRAK31.55470404
32NME21.53191367
33LCK1.49817362
34EPHB11.41063180
35TRIB31.40933877
36CLK11.38368175
37SIK21.31551514
38MAP2K31.30288587
39BMPR21.24671978
40* LYN1.24416842
41* CSF1R1.24390777
42MAP3K131.23585606
43TAOK11.23465856
44TAOK31.21477247
45PIM11.19895877
46FGFR41.19451421
47RPS6KA41.14785577
48FLT31.10915525
49MAP3K11.06921187
50FGFR31.01759515
51PIM20.96516639
52MARK30.96478070
53JAK20.92859279
54TAOK20.85372673
55TESK20.84603571
56IRAK10.82317779
57KDR0.79360380
58CHUK0.78890238
59NEK20.78334218
60YES10.77880614
61KSR20.77677676
62MATK0.77336944
63NLK0.77115816
64CDK40.76956445
65TNK20.76529873
66TGFBR10.76426801
67CAMKK20.72346790
68STK40.71719248
69MARK20.69949459
70PIK3CG0.69860641
71SMG10.69726522
72GRK70.69151593
73SCYL20.68437647
74PTK60.66858854
75ALK0.65031953
76CDC42BPA0.63961961
77IRAK20.63668468
78CDK190.61858095
79PRKCQ0.61665246
80MAPK70.61306608
81PDPK10.60319036
82CDK120.59587374
83MAPK40.59024688
84TRPM70.58128848
85CAMKK10.56262197
86MST40.55439921
87MAP3K80.53944820
88NEK90.53350665
89TTN0.53262340
90SIK30.53192510
91* FGR0.52385333
92PRKD20.51626396
93PRKCH0.51364546
94MAP3K110.49457941
95PAK40.49291548
96PDK10.49041645
97CDK60.48842590
98RPS6KA60.48152619
99CAMK1D0.47532143
100ABL10.47227038
101MAP3K50.47025077
102HIPK20.45565757
103MAPKAPK20.44634492
104MAP2K60.43735643
105MAPK110.42693962
106RPS6KB20.39755974
107PRKCD0.38999006
108PTK2B0.36161253
109RPS6KC10.35338306
110RPS6KL10.35338306
111EPHA30.33427020
112STK110.33285511
113MAP2K20.32981771
114MAP3K60.32258687
115DYRK1B0.31908111
116FYN0.31432164
117MAP3K30.30409254
118* EGFR0.30385267
119RET0.29640328
120STK240.27772141
121ACVR1B0.26908117
122SGK30.26661062
123ATR0.26387741
124EIF2AK30.26318444
125CDC70.26195234
126RAF10.25082546
127MAPK30.24382744
128MAP3K70.24360863
129MAPK120.24288710
130RPS6KA50.22756397
131CAMK1G0.21449266

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.47952702
2Leishmaniasis_Homo sapiens_hsa051403.10374642
3B cell receptor signaling pathway_Homo sapiens_hsa046622.99726043
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.57320118
5Osteoclast differentiation_Homo sapiens_hsa043802.53545671
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29043639
7Measles_Homo sapiens_hsa051622.28490098
8Antigen processing and presentation_Homo sapiens_hsa046122.26319666
9Staphylococcus aureus infection_Homo sapiens_hsa051502.23545994
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.17897455
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14658105
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08384821
13Hematopoietic cell lineage_Homo sapiens_hsa046402.05394947
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96609083
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81394316
16T cell receptor signaling pathway_Homo sapiens_hsa046601.81126766
17Tuberculosis_Homo sapiens_hsa051521.75837794
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75629163
19Allograft rejection_Homo sapiens_hsa053301.75376856
20Legionellosis_Homo sapiens_hsa051341.74984400
21Pertussis_Homo sapiens_hsa051331.73182809
22Herpes simplex infection_Homo sapiens_hsa051681.68861025
23Graft-versus-host disease_Homo sapiens_hsa053321.66211198
24Other glycan degradation_Homo sapiens_hsa005111.65675151
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65202326
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62112689
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.56631864
28Malaria_Homo sapiens_hsa051441.53413286
29Toxoplasmosis_Homo sapiens_hsa051451.53406365
30Influenza A_Homo sapiens_hsa051641.51395799
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.47922713
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44538391
33Chemokine signaling pathway_Homo sapiens_hsa040621.43583566
34Acute myeloid leukemia_Homo sapiens_hsa052211.39835459
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.36382720
36Apoptosis_Homo sapiens_hsa042101.35467844
37Hepatitis B_Homo sapiens_hsa051611.34416204
38DNA replication_Homo sapiens_hsa030301.32801024
39* Shigellosis_Homo sapiens_hsa051311.32496751
40Asthma_Homo sapiens_hsa053101.31915206
41TNF signaling pathway_Homo sapiens_hsa046681.28828860
42Lysosome_Homo sapiens_hsa041421.24877875
43Salmonella infection_Homo sapiens_hsa051321.22297481
44Viral myocarditis_Homo sapiens_hsa054161.17469026
45Chronic myeloid leukemia_Homo sapiens_hsa052201.13799298
46Platelet activation_Homo sapiens_hsa046111.07225859
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06211234
48Ribosome_Homo sapiens_hsa030101.05388954
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01677316
50Epstein-Barr virus infection_Homo sapiens_hsa051691.00264159
51Base excision repair_Homo sapiens_hsa034100.98317328
52Pancreatic cancer_Homo sapiens_hsa052120.98310708
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95945665
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92814396
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90245764
56Hepatitis C_Homo sapiens_hsa051600.88218919
57Rheumatoid arthritis_Homo sapiens_hsa053230.87458631
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86925128
59Viral carcinogenesis_Homo sapiens_hsa052030.85255245
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.83663003
61Phagosome_Homo sapiens_hsa041450.82436081
62Autoimmune thyroid disease_Homo sapiens_hsa053200.82350556
63African trypanosomiasis_Homo sapiens_hsa051430.75702159
64* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75227381
65HTLV-I infection_Homo sapiens_hsa051660.73645136
66Non-small cell lung cancer_Homo sapiens_hsa052230.73432422
67Mismatch repair_Homo sapiens_hsa034300.72410465
68Type I diabetes mellitus_Homo sapiens_hsa049400.71425851
69Non-homologous end-joining_Homo sapiens_hsa034500.69602886
70* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69201872
71VEGF signaling pathway_Homo sapiens_hsa043700.67401834
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65080752
73Prolactin signaling pathway_Homo sapiens_hsa049170.60940095
74Small cell lung cancer_Homo sapiens_hsa052220.57073909
75Caffeine metabolism_Homo sapiens_hsa002320.56021736
76Colorectal cancer_Homo sapiens_hsa052100.53822306
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53064469
78HIF-1 signaling pathway_Homo sapiens_hsa040660.52351580
79Notch signaling pathway_Homo sapiens_hsa043300.50969463
80Spliceosome_Homo sapiens_hsa030400.48306136
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47671124
82Pentose phosphate pathway_Homo sapiens_hsa000300.47253351
83Endocytosis_Homo sapiens_hsa041440.46189717
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.45422366
85p53 signaling pathway_Homo sapiens_hsa041150.42849472
86Homologous recombination_Homo sapiens_hsa034400.42079229
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.40902717
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38414420
89Amoebiasis_Homo sapiens_hsa051460.38367470
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38353724
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.38065974
92Choline metabolism in cancer_Homo sapiens_hsa052310.37069838
93Systemic lupus erythematosus_Homo sapiens_hsa053220.36582004
94GnRH signaling pathway_Homo sapiens_hsa049120.34769700
95Dorso-ventral axis formation_Homo sapiens_hsa043200.34497880
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33664707
97Insulin resistance_Homo sapiens_hsa049310.32423374
98Endometrial cancer_Homo sapiens_hsa052130.32173572
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28678069
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27813424
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27005776
102FoxO signaling pathway_Homo sapiens_hsa040680.26976115
103Regulation of autophagy_Homo sapiens_hsa041400.26754062
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.26620759
105MicroRNAs in cancer_Homo sapiens_hsa052060.26532819
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26386459
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26207356
108Cell cycle_Homo sapiens_hsa041100.24624028
109Type II diabetes mellitus_Homo sapiens_hsa049300.24433227
110Inositol phosphate metabolism_Homo sapiens_hsa005620.21699302
111Prostate cancer_Homo sapiens_hsa052150.21099337
112MAPK signaling pathway_Homo sapiens_hsa040100.20785262
113mTOR signaling pathway_Homo sapiens_hsa041500.20748048
114Renal cell carcinoma_Homo sapiens_hsa052110.19898519
115Nucleotide excision repair_Homo sapiens_hsa034200.19740912
116Rap1 signaling pathway_Homo sapiens_hsa040150.18017050
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17899965

Most similar genes based on co-expression Upload to Enrichr

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