HCN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.88330960
2doxorubicin metabolic process (GO:0044598)8.88330960
3daunorubicin metabolic process (GO:0044597)8.88330960
4regulation of cardioblast differentiation (GO:0051890)6.49904826
5muscle organ morphogenesis (GO:0048644)5.92684189
6somite rostral/caudal axis specification (GO:0032525)5.81498498
7cardiac chamber formation (GO:0003207)5.69948360
8maintenance of protein location in nucleus (GO:0051457)5.66291917
9sarcomere organization (GO:0045214)5.66081339
10sperm motility (GO:0030317)5.63737698
11aminoglycoside antibiotic metabolic process (GO:0030647)5.60052306
12negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.58533168
13acrosome reaction (GO:0007340)5.52601238
14regulation of mammary gland epithelial cell proliferation (GO:0033599)5.51499084
15regulation of response to osmotic stress (GO:0047484)5.45676986
16adult heart development (GO:0007512)5.33998184
17negative regulation of epidermis development (GO:0045683)5.30057034
18synaptic vesicle maturation (GO:0016188)5.27135779
19cardiac myofibril assembly (GO:0055003)5.11667653
20proline transport (GO:0015824)5.09778503
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.01467739
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.00195060
23myofibril assembly (GO:0030239)4.97547555
24atrial septum morphogenesis (GO:0060413)4.88457020
25histone H4-K8 acetylation (GO:0043982)4.87360421
26histone H4-K5 acetylation (GO:0043981)4.87360421
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.74414337
28cardiac ventricle formation (GO:0003211)4.71668575
29cardiac muscle hypertrophy (GO:0003300)4.61494166
30cytidine metabolic process (GO:0046087)4.59952732
31cytidine catabolic process (GO:0006216)4.59952732
32cytidine deamination (GO:0009972)4.59952732
33chromosome condensation (GO:0030261)4.59390378
34regulation of the force of heart contraction (GO:0002026)4.58162554
35histone H4-K12 acetylation (GO:0043983)4.57726089
36cardiac muscle cell development (GO:0055013)4.57566040
37negative regulation of potassium ion transmembrane transport (GO:1901380)4.55450998
38fusion of sperm to egg plasma membrane (GO:0007342)4.43377977
39regulation of telomere maintenance via telomerase (GO:0032210)4.43112546
40response to dietary excess (GO:0002021)4.40732075
41outflow tract septum morphogenesis (GO:0003148)4.39975447
42negative regulation of cell cycle G2/M phase transition (GO:1902750)4.38959876
43sperm capacitation (GO:0048240)4.38815095
44striated muscle hypertrophy (GO:0014897)4.34624409
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.33514291
46cell communication by electrical coupling (GO:0010644)4.31110748
47DNA packaging (GO:0006323)4.30687116
48single strand break repair (GO:0000012)4.28702872
49regulation of MHC class I biosynthetic process (GO:0045343)4.28296858
50bundle of His cell to Purkinje myocyte communication (GO:0086069)4.26885414
51cardiac cell development (GO:0055006)4.26301294
52regulation of cilium movement (GO:0003352)4.24195960
53phenol-containing compound catabolic process (GO:0019336)4.22984830
54spermatid development (GO:0007286)4.21864657
55cardiac muscle hypertrophy in response to stress (GO:0014898)4.17170107
56muscle hypertrophy in response to stress (GO:0003299)4.17170107
57cardiac muscle adaptation (GO:0014887)4.17170107
58hormone catabolic process (GO:0042447)4.14789576
59mitochondrion distribution (GO:0048311)4.14298208
60primitive streak formation (GO:0090009)4.09454580
61rRNA transcription (GO:0009303)4.08500826
62negative regulation of striated muscle cell apoptotic process (GO:0010664)4.08069762
63ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.03373809
64regulation of actin filament-based movement (GO:1903115)3.99503510
65negative regulation of telomerase activity (GO:0051974)3.95604437
66cardiac muscle contraction (GO:0060048)3.86924260
67regulation of cardioblast proliferation (GO:0003264)3.85544005
68regulation of secondary heart field cardioblast proliferation (GO:0003266)3.85544005
69cardiac muscle tissue morphogenesis (GO:0055008)3.84096265
70actin-myosin filament sliding (GO:0033275)3.82255526
71muscle filament sliding (GO:0030049)3.82255526
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.81179549
73microtubule depolymerization (GO:0007019)3.78260057
74notochord development (GO:0030903)3.77395474
75nucleoside transmembrane transport (GO:1901642)3.76812581
76negative regulation of epidermal cell differentiation (GO:0045605)3.76509848
77pyrimidine ribonucleoside catabolic process (GO:0046133)3.76433673
78pre-miRNA processing (GO:0031054)3.69229487
79coenzyme catabolic process (GO:0009109)3.68695245
80heterochromatin organization (GO:0070828)3.68124562
81muscle hypertrophy (GO:0014896)3.67833171
82muscle tissue morphogenesis (GO:0060415)3.66579274
83cell communication involved in cardiac conduction (GO:0086065)3.66097052
84protein localization to kinetochore (GO:0034501)3.65772423
85histone H4-K16 acetylation (GO:0043984)3.65399162
86regulation of microtubule-based movement (GO:0060632)3.64053078
87microtubule severing (GO:0051013)3.62400781
88calcium ion-dependent exocytosis (GO:0017156)3.61066922
89response to pheromone (GO:0019236)3.60680179
90maintenance of protein localization in organelle (GO:0072595)3.57847458
91branching involved in mammary gland duct morphogenesis (GO:0060444)3.54982408
92actomyosin structure organization (GO:0031032)3.54489998
93calcium-mediated signaling using intracellular calcium source (GO:0035584)3.52309224
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.50758627
95ventricular system development (GO:0021591)3.50326772
96spermatid nucleus differentiation (GO:0007289)3.47966543
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47670561
98microtubule polymerization or depolymerization (GO:0031109)3.47269176
99quinone metabolic process (GO:1901661)3.44553363
100motile cilium assembly (GO:0044458)3.43659284
101ventricular cardiac muscle cell action potential (GO:0086005)3.42049265
102protein targeting to Golgi (GO:0000042)3.40458036
103axonemal dynein complex assembly (GO:0070286)3.40243989
104cell junction maintenance (GO:0034331)3.38660890
105cellular component maintenance (GO:0043954)3.36088220
106cardiovascular system development (GO:0072358)3.33780354
107tachykinin receptor signaling pathway (GO:0007217)3.32493348
108detection of temperature stimulus (GO:0016048)3.31484823
109mitochondrion localization (GO:0051646)3.31250803
110sperm-egg recognition (GO:0035036)3.29626059
111retrograde transport, vesicle recycling within Golgi (GO:0000301)3.29616305
112receptor recycling (GO:0001881)3.29296083
113establishment of protein localization to Golgi (GO:0072600)3.28762518
114atrioventricular valve morphogenesis (GO:0003181)3.27787211
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.26728053
116cardiac right ventricle morphogenesis (GO:0003215)3.26095183
117protein polyglutamylation (GO:0018095)3.24798727
118icosanoid secretion (GO:0032309)3.23740131
119arachidonic acid secretion (GO:0050482)3.23740131
120plasma membrane fusion (GO:0045026)3.21667426
121negative regulation of inclusion body assembly (GO:0090084)3.20243829
122retinoic acid receptor signaling pathway (GO:0048384)3.16905154
123positive regulation of action potential (GO:0045760)3.15897904
124* regulation of heart rate (GO:0002027)3.15419437
125interferon-gamma production (GO:0032609)3.15008143
126layer formation in cerebral cortex (GO:0021819)3.14697950
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.13418863
128binding of sperm to zona pellucida (GO:0007339)3.10281458
129spermatogenesis (GO:0007283)3.09969121
130bone trabecula formation (GO:0060346)3.09843222
131regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.09673356
132male gamete generation (GO:0048232)3.08688463
133actin-mediated cell contraction (GO:0070252)3.08643589
134regulation of glucose import in response to insulin stimulus (GO:2001273)3.08188418
135positive regulation of histone deacetylation (GO:0031065)3.06807311
136regulation of cardiac muscle cell contraction (GO:0086004)3.06352687
137positive regulation of cardiac muscle cell proliferation (GO:0060045)3.02975403
138regulation of apoptotic process involved in morphogenesis (GO:1902337)3.02923164
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.02318374
140seminiferous tubule development (GO:0072520)3.01313899
141multicellular organism reproduction (GO:0032504)3.00029020
142positive regulation of axon extension (GO:0045773)2.99214539
143positive regulation of protein deacetylation (GO:0090312)2.98681298
144positive regulation of cardiac muscle tissue growth (GO:0055023)2.96133102
145chromatin silencing (GO:0006342)2.96086466
146cellular modified amino acid catabolic process (GO:0042219)2.95883086
147regulation of sarcomere organization (GO:0060297)2.94413535
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93354656
149ventricular cardiac muscle cell development (GO:0055015)2.93179981
150intestinal epithelial cell development (GO:0060576)2.92906227
151intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.92282674
152negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.92020445
153transepithelial transport (GO:0070633)2.91510245
154RNA localization (GO:0006403)2.91135202
155positive regulation of DNA-dependent DNA replication (GO:2000105)2.89892000
156left/right pattern formation (GO:0060972)2.89616367
157melanosome transport (GO:0032402)2.88476249
158cardiac septum development (GO:0003279)2.88349894
159establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87790846
160mitochondrion transport along microtubule (GO:0047497)2.87790846
161rRNA methylation (GO:0031167)2.85600626
162regulation of cardiac muscle cell apoptotic process (GO:0010665)2.85378169
163intracellular estrogen receptor signaling pathway (GO:0030520)2.84755327
164negative regulation of cell size (GO:0045792)2.84686246
165chromatin assembly (GO:0031497)2.84498415
166vitamin A metabolic process (GO:0006776)2.83595947
167histone H3-K4 methylation (GO:0051568)2.83414890
168gamete generation (GO:0007276)2.83386794
169positive regulation of cardiac muscle tissue development (GO:0055025)2.83294215
170cardiac conduction (GO:0061337)2.82175598
171positive regulation of heart growth (GO:0060421)2.81778855
172establishment of melanosome localization (GO:0032401)2.80885751
173negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.80472180
174striated muscle contraction (GO:0006941)2.80328831
175* regulation of heart contraction (GO:0008016)2.79844148
176positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79199887
177negative regulation of telomere maintenance (GO:0032205)2.79110609
178cell migration involved in gastrulation (GO:0042074)2.79033405
179reproduction (GO:0000003)2.77902671
180cell migration in hindbrain (GO:0021535)2.77558312
181regulation of ATPase activity (GO:0043462)2.76013734
182regulation of ATP catabolic process (GO:1903289)2.76013734
183regulation of heart growth (GO:0060420)2.75546511
184mitotic sister chromatid segregation (GO:0000070)2.74699743
185epoxygenase P450 pathway (GO:0019373)2.73291816
186cell fate commitment involved in formation of primary germ layer (GO:0060795)2.72420920
187negative regulation of myotube differentiation (GO:0010832)2.72381025
188planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72304740
189regulation of cardiac muscle cell proliferation (GO:0060043)2.71602412
190phosphatidylinositol 3-kinase signaling (GO:0014065)2.71164671
191regulation of telomere maintenance (GO:0032204)2.70898576
192glomerular visceral epithelial cell development (GO:0072015)2.69846702
193regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69682226
194pigment granule transport (GO:0051904)2.69564586
195signal transduction involved in regulation of gene expression (GO:0023019)2.69427733
196pyrimidine nucleobase catabolic process (GO:0006208)2.68037925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.72538950
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.68809749
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.68809749
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.68809749
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.18432792
6NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.11037537
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.99685595
8SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.89943761
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63830694
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50816181
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.31723003
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.26202102
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26202102
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.21403391
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.20833664
16NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.17359193
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08680027
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.08622836
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.08525690
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.04585629
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03903494
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00860139
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.99049384
24DROSHA_22980978_ChIP-Seq_HELA_Human1.94776130
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94748272
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89830143
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87463382
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81485686
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80080723
30* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79263542
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.77980515
32TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.74804570
33CTCF_27219007_Chip-Seq_Bcells_Human1.73771761
34* KDM2B_26808549_Chip-Seq_K562_Human1.72483064
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.71019851
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70801631
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67367175
38* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66608015
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66471478
40POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65239703
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.64458000
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64046082
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63824084
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62777383
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60193866
46EZH2_22144423_ChIP-Seq_EOC_Human1.58613473
47E2F1_17053090_ChIP-ChIP_MCF-7_Human1.56316338
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54059550
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52434662
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52145968
51* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.51605014
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49585185
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.49563535
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.47275711
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46211057
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45855922
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45765649
58FUS_26573619_Chip-Seq_HEK293_Human1.45677279
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42887229
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.40893505
61* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40551665
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39239204
63SMAD3_21741376_ChIP-Seq_ESCs_Human1.39122011
64* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38902108
65TAF15_26573619_Chip-Seq_HEK293_Human1.38814110
66SMAD4_21741376_ChIP-Seq_HESCs_Human1.38794523
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.38090609
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36146511
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35416348
70* ISL1_27105846_Chip-Seq_CPCs_Mouse1.34416977
71GBX2_23144817_ChIP-Seq_PC3_Human1.34366835
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34034376
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32366339
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31905141
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31758236
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30534830
77CBP_20019798_ChIP-Seq_JUKART_Human1.30534830
78* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30305311
79* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30305311
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.30013381
81P300_19829295_ChIP-Seq_ESCs_Human1.28003681
82IRF1_19129219_ChIP-ChIP_H3396_Human1.27772351
83* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27145281
84* REST_21632747_ChIP-Seq_MESCs_Mouse1.27034983
85SMAD4_21799915_ChIP-Seq_A2780_Human1.26715541
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.26535796
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.26179880
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25830882
89IGF1R_20145208_ChIP-Seq_DFB_Human1.25689440
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.24724831
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22960629
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22628265
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22086175
94NANOG_18692474_ChIP-Seq_MESCs_Mouse1.21953860
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.21332612
96* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20933712
97LXR_22292898_ChIP-Seq_THP-1_Human1.19818179
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17983809
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17569808
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17557792
101SMC4_20622854_ChIP-Seq_HELA_Human1.17463928
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16857478
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13754700
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13422746
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12721978
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12031196
107NANOG_16518401_ChIP-PET_MESCs_Mouse1.11832469
108SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11560840
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11326603
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.10844274
111RNF2_27304074_Chip-Seq_NSC_Mouse1.10426744
112TBL1_22424771_ChIP-Seq_293T_Human1.10161694
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.09921530
114TP53_22127205_ChIP-Seq_IMR90_Human1.09423310
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09101131
116* RNF2_27304074_Chip-Seq_ESCs_Mouse1.07639261
117TCF7_22412390_ChIP-Seq_EML_Mouse1.06693820
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06425537
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05636247
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05411044
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.04812919
122* EZH2_27304074_Chip-Seq_ESCs_Mouse1.03146137
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03045465
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02815323
125RUNX2_22187159_ChIP-Seq_PCA_Human1.02287383
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.02156631
127SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01859759
128AR_25329375_ChIP-Seq_VCAP_Human1.00874002
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00092665
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99778661
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99153076
132* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99022998
133ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98701578
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98603012
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98575404
136AR_19668381_ChIP-Seq_PC3_Human0.98458220
137STAT3_23295773_ChIP-Seq_U87_Human0.97113226
138VDR_22108803_ChIP-Seq_LS180_Human0.96476587
139KDM2B_26808549_Chip-Seq_DND41_Human0.95599734
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94238118
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.93394963
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.93156207
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92755495
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92626218
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.92459269
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92052433
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91877580
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91628374
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91276377
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91041937
151* GF1_26923725_Chip-Seq_HPCs_Mouse0.91009292
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90384694
153NFYB_21822215_ChIP-Seq_K562_Human0.90326107
154RACK7_27058665_Chip-Seq_MCF-7_Human0.89878727
155* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89817479
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89687351
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89578078
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88751928
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88563316
160CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88027253
161* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86943794
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86719720
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86328049
164GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86284825
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86225529
166* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86150784
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85914845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.44268275
2MP0004858_abnormal_nervous_system4.07194245
3MP0003122_maternal_imprinting3.83472028
4MP0006292_abnormal_olfactory_placode3.70901839
5MP0003890_abnormal_embryonic-extraembry3.46539983
6MP0005499_abnormal_olfactory_system3.46352849
7MP0005394_taste/olfaction_phenotype3.46352849
8MP0002653_abnormal_ependyma_morphology3.41021838
9MP0004264_abnormal_extraembryonic_tissu3.35831897
10MP0004036_abnormal_muscle_relaxation3.21430373
11MP0003011_delayed_dark_adaptation3.03305877
12MP0002254_reproductive_system_inflammat2.98707444
13MP0003878_abnormal_ear_physiology2.80055778
14MP0005377_hearing/vestibular/ear_phenot2.80055778
15MP0002332_abnormal_exercise_endurance2.55282562
16MP0008961_abnormal_basal_metabolism2.54720054
17MP0003121_genomic_imprinting2.39111250
18MP0005670_abnormal_white_adipose2.15339928
19MP0002909_abnormal_adrenal_gland2.14668555
20MP0002234_abnormal_pharynx_morphology2.12707143
21MP0000751_myopathy2.09690818
22MP0000678_abnormal_parathyroid_gland2.05668035
23MP0004043_abnormal_pH_regulation2.04623005
24MP0001348_abnormal_lacrimal_gland1.95738207
25MP0003567_abnormal_fetal_cardiomyocyte1.94489396
26MP0003283_abnormal_digestive_organ1.93229729
27MP0005257_abnormal_intraocular_pressure1.92847375
28MP0003705_abnormal_hypodermis_morpholog1.90192039
29* MP0002972_abnormal_cardiac_muscle1.89903938
30MP0004270_analgesia1.85595846
31MP0003698_abnormal_male_reproductive1.85103625
32MP0005075_abnormal_melanosome_morpholog1.84878650
33MP0002127_abnormal_cardiovascular_syste1.80788976
34MP0006035_abnormal_mitochondrial_morpho1.77065334
35MP0002822_catalepsy1.72463736
36MP0010030_abnormal_orbit_morphology1.71055688
37MP0004510_myositis1.70367153
38* MP0003137_abnormal_impulse_conducting1.64258757
39MP0004084_abnormal_cardiac_muscle1.51861461
40MP0005423_abnormal_somatic_nervous1.51825228
41MP0008789_abnormal_olfactory_epithelium1.51073532
42MP0001984_abnormal_olfaction1.48121757
43* MP0005620_abnormal_muscle_contractility1.48038021
44MP0001849_ear_inflammation1.46989975
45MP0001929_abnormal_gametogenesis1.46403641
46MP0004859_abnormal_synaptic_plasticity1.43775412
47MP0003646_muscle_fatigue1.42565810
48MP0002102_abnormal_ear_morphology1.40934840
49MP0003183_abnormal_peptide_metabolism1.39899930
50MP0003938_abnormal_ear_development1.39278561
51MP0001544_abnormal_cardiovascular_syste1.38077978
52MP0005385_cardiovascular_system_phenoty1.38077978
53MP0003787_abnormal_imprinting1.30855056
54MP0000749_muscle_degeneration1.30765473
55MP0003123_paternal_imprinting1.30708470
56MP0002249_abnormal_larynx_morphology1.29049271
57MP0002932_abnormal_joint_morphology1.26783538
58MP0008877_abnormal_DNA_methylation1.26570658
59MP0002733_abnormal_thermal_nociception1.25819728
60MP0000534_abnormal_ureter_morphology1.24037716
61MP0003119_abnormal_digestive_system1.24024525
62MP0005380_embryogenesis_phenotype1.22334227
63MP0001672_abnormal_embryogenesis/_devel1.22334227
64MP0003941_abnormal_skin_development1.21990961
65MP0004215_abnormal_myocardial_fiber1.21525857
66MP0002269_muscular_atrophy1.21212660
67MP0000955_abnormal_spinal_cord1.21149093
68MP0005248_abnormal_Harderian_gland1.20615804
69MP0005623_abnormal_meninges_morphology1.20441300
70MP0002088_abnormal_embryonic_growth/wei1.20402368
71MP0000049_abnormal_middle_ear1.20021259
72MP0010352_gastrointestinal_tract_polyps1.18537896
73MP0004133_heterotaxia1.17637995
74MP0003984_embryonic_growth_retardation1.17142914
75MP0001485_abnormal_pinna_reflex1.15287751
76MP0001293_anophthalmia1.15013018
77MP0002837_dystrophic_cardiac_calcinosis1.13921215
78* MP0004085_abnormal_heartbeat1.13312801
79MP0000762_abnormal_tongue_morphology1.13297810
80MP0003942_abnormal_urinary_system1.10244798
81MP0004145_abnormal_muscle_electrophysio1.09929789
82MP0000428_abnormal_craniofacial_morphol1.08250587
83MP0002751_abnormal_autonomic_nervous1.07207822
84MP0002161_abnormal_fertility/fecundity1.07070527
85MP0001299_abnormal_eye_distance/1.05825126
86MP0002233_abnormal_nose_morphology1.04993258
87MP0003880_abnormal_central_pattern1.04986644
88MP0003935_abnormal_craniofacial_develop1.03786851
89MP0000566_synostosis1.03648615
90MP0000778_abnormal_nervous_system1.03587898
91MP0002114_abnormal_axial_skeleton1.03491887
92MP0006276_abnormal_autonomic_nervous1.03215236
93MP0002734_abnormal_mechanical_nocicepti1.02937779
94MP0009053_abnormal_anal_canal1.02815979
95MP0002184_abnormal_innervation1.02628633
96MP0003937_abnormal_limbs/digits/tail_de1.01168741
97MP0005330_cardiomyopathy1.00167597
98MP0002063_abnormal_learning/memory/cond1.00112241
99MP0003635_abnormal_synaptic_transmissio0.99092479
100MP0002735_abnormal_chemical_nociception0.97667194
101MP0003755_abnormal_palate_morphology0.97560588
102MP0002970_abnormal_white_adipose0.96614116
103MP0002092_abnormal_eye_morphology0.96515986
104MP0000759_abnormal_skeletal_muscle0.95036869
105MP0008057_abnormal_DNA_replication0.95000149
106MP0005266_abnormal_metabolism0.94849738
107MP0009384_cardiac_valve_regurgitation0.94002956
108MP0002272_abnormal_nervous_system0.93789946
109MP0009046_muscle_twitch0.93745569
110MP0002877_abnormal_melanocyte_morpholog0.93551883
111MP0002106_abnormal_muscle_physiology0.92584130
112MP0001529_abnormal_vocalization0.92512691
113MP0008770_decreased_survivor_rate0.92484170
114MP0002116_abnormal_craniofacial_bone0.91921786
115MP0003221_abnormal_cardiomyocyte_apopto0.91763801
116MP0001486_abnormal_startle_reflex0.90659704
117MP0003172_abnormal_lysosome_physiology0.90565732
118MP0005253_abnormal_eye_physiology0.89200964
119MP0002557_abnormal_social/conspecific_i0.88812925
120MP0002210_abnormal_sex_determination0.88663527
121MP0000750_abnormal_muscle_regeneration0.88401113
122MP0004484_altered_response_of0.88393541
123MP0002572_abnormal_emotion/affect_behav0.88326771
124MP0002277_abnormal_respiratory_mucosa0.88122369
125MP0002085_abnormal_embryonic_tissue0.87797631
126MP0006138_congestive_heart_failure0.87366399
127MP0003861_abnormal_nervous_system0.86490492
128MP0004087_abnormal_muscle_fiber0.86442279
129MP0001963_abnormal_hearing_physiology0.86043021
130MP0000026_abnormal_inner_ear0.85984884
131MP0000631_abnormal_neuroendocrine_gland0.85907773
132MP0005391_vision/eye_phenotype0.85231935
133MP0003718_maternal_effect0.84653876
134MP0001970_abnormal_pain_threshold0.84414148
135MP0003385_abnormal_body_wall0.84287491
136MP0002925_abnormal_cardiovascular_devel0.82363422
137MP0002697_abnormal_eye_size0.81931864
138MP0002086_abnormal_extraembryonic_tissu0.81923107
139MP0010630_abnormal_cardiac_muscle0.81012576
140MP0002752_abnormal_somatic_nervous0.80635509
141MP0009745_abnormal_behavioral_response0.80487721
142MP0002084_abnormal_developmental_patter0.80485330
143MP0000266_abnormal_heart_morphology0.80112598
144MP0002081_perinatal_lethality0.79909753
145MP0002067_abnormal_sensory_capabilities0.79306460
146MP0005369_muscle_phenotype0.78375671
147MP0002882_abnormal_neuron_morphology0.76524316
148MP0001440_abnormal_grooming_behavior0.74049445
149MP0006072_abnormal_retinal_apoptosis0.73711388
150MP0008775_abnormal_heart_ventricle0.73298639
151MP0005508_abnormal_skeleton_morphology0.72288945
152MP0000569_abnormal_digit_pigmentation0.72287026
153MP0004957_abnormal_blastocyst_morpholog0.71057631
154MP0001145_abnormal_male_reproductive0.70957361
155MP0001968_abnormal_touch/_nociception0.67695689

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.87345397
2Hepatoblastoma (HP:0002884)5.65951471
3Abnormality of the lower motor neuron (HP:0002366)5.21831833
4Hypochromic microcytic anemia (HP:0004840)4.99030987
5Sudden death (HP:0001699)4.87486252
6Double outlet right ventricle (HP:0001719)4.85590357
7Congenital malformation of the right heart (HP:0011723)4.85590357
8Multiple enchondromatosis (HP:0005701)4.62869463
9* Atrial fibrillation (HP:0005110)4.57982890
10* Primary atrial arrhythmia (HP:0001692)4.25414544
11Bundle branch block (HP:0011710)4.18052701
12* Supraventricular tachycardia (HP:0004755)4.05088530
13* Ventricular tachycardia (HP:0004756)4.04999329
14Transposition of the great arteries (HP:0001669)4.04239363
15Abnormal connection of the cardiac segments (HP:0011545)4.04239363
16Abnormal ventriculo-arterial connection (HP:0011563)4.04239363
17Rib fusion (HP:0000902)4.00007417
18* Supraventricular arrhythmia (HP:0005115)3.94737065
19Hyperinsulinemic hypoglycemia (HP:0000825)3.93707215
20Hypoplastic left heart (HP:0004383)3.93659657
21Syncope (HP:0001279)3.92656942
22Myokymia (HP:0002411)3.81400368
23Ependymoma (HP:0002888)3.78996223
24Asymmetric septal hypertrophy (HP:0001670)3.71347217
25Amyotrophic lateral sclerosis (HP:0007354)3.68528403
26Abnormality of the left ventricular outflow tract (HP:0011103)3.60866563
27Subaortic stenosis (HP:0001682)3.60866563
28Difficulty running (HP:0009046)3.57587663
29Bifid tongue (HP:0010297)3.50606747
30Right ventricular cardiomyopathy (HP:0011663)3.47580723
31Hyperventilation (HP:0002883)3.22658235
32Abnormality of the astrocytes (HP:0100707)3.18207934
33Astrocytoma (HP:0009592)3.18207934
34Hypoplastic heart (HP:0001961)3.16090021
35Lipoatrophy (HP:0100578)3.14114883
36Testicular atrophy (HP:0000029)3.10102508
37Ragged-red muscle fibers (HP:0003200)3.05900471
38Rectal fistula (HP:0100590)3.00894701
39Rectovaginal fistula (HP:0000143)3.00894701
40Severe visual impairment (HP:0001141)2.99599138
41Abnormality of the salivary glands (HP:0010286)2.97508607
42Abnormality of the aortic arch (HP:0012303)2.95675069
43Hypoplastic ischia (HP:0003175)2.94530590
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.93249802
45Hypoplasia of the fovea (HP:0007750)2.93249802
46Pendular nystagmus (HP:0012043)2.92150930
47Dilated cardiomyopathy (HP:0001644)2.89946993
48Neoplasm of striated muscle (HP:0009728)2.87233296
49Heart block (HP:0012722)2.85844978
50Generalized hypotonia (HP:0001290)2.85773032
51Partial duplication of thumb phalanx (HP:0009944)2.84864486
52Chronic hepatic failure (HP:0100626)2.84499321
53Neoplasm of the heart (HP:0100544)2.82301349
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.80078462
55Absent/shortened dynein arms (HP:0200106)2.80078462
56Maternal diabetes (HP:0009800)2.78369464
57Renal duplication (HP:0000075)2.78359390
58Impulsivity (HP:0100710)2.73619029
59Intestinal fistula (HP:0100819)2.73083533
60Abnormality of the ischium (HP:0003174)2.70468877
61Nephroblastoma (Wilms tumor) (HP:0002667)2.69974187
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62902080
63Progressive cerebellar ataxia (HP:0002073)2.62121895
64Ventricular arrhythmia (HP:0004308)2.61708359
65Vaginal fistula (HP:0004320)2.59545039
66Anomalous pulmonary venous return (HP:0010772)2.59076714
67Abnormality of the pubic bones (HP:0003172)2.58925545
68Prolonged QT interval (HP:0001657)2.58733193
69Left ventricular hypertrophy (HP:0001712)2.58680070
70Fused cervical vertebrae (HP:0002949)2.57689927
71Tetraplegia (HP:0002445)2.56463767
72Horizontal nystagmus (HP:0000666)2.55414876
73Periauricular skin pits (HP:0100277)2.54242055
74Preauricular pit (HP:0004467)2.54242055
75Patent foramen ovale (HP:0001655)2.52471280
76Abnormal atrioventricular conduction (HP:0005150)2.51637477
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49970931
78Embryonal renal neoplasm (HP:0011794)2.49223712
79Partial duplication of the phalanx of hand (HP:0009999)2.46809840
80Truncus arteriosus (HP:0001660)2.45162936
81Abnormal ciliary motility (HP:0012262)2.42578993
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41507006
83Vitreoretinal degeneration (HP:0000655)2.36763283
84Abnormality of the corticospinal tract (HP:0002492)2.36488210
85Osteomalacia (HP:0002749)2.36257437
86Abnormal cartilage morphology (HP:0002763)2.34862121
87Agitation (HP:0000713)2.34217351
88Abnormal respiratory motile cilium physiology (HP:0012261)2.33237298
89Hemiparesis (HP:0001269)2.32669531
90Tubulointerstitial nephritis (HP:0001970)2.32505442
91Infertility (HP:0000789)2.31784168
92Midline defect of the nose (HP:0004122)2.31363953
93Rhabdomyosarcoma (HP:0002859)2.30810018
94Abnormality of the musculature of the hand (HP:0001421)2.30728390
95Amblyopia (HP:0000646)2.30664092
96Bell-shaped thorax (HP:0001591)2.30417643
97Abnormal respiratory epithelium morphology (HP:0012253)2.28522833
98Abnormal respiratory motile cilium morphology (HP:0005938)2.28522833
99Abnormality of the fovea (HP:0000493)2.27655809
100Short humerus (HP:0005792)2.25431373
101* Abnormal EKG (HP:0003115)2.24076592
102Increased connective tissue (HP:0009025)2.23887251
103Abnormality of chromosome segregation (HP:0002916)2.23216669
104EMG: neuropathic changes (HP:0003445)2.22126371
105Short 5th finger (HP:0009237)2.22011488
106Abdominal situs inversus (HP:0003363)2.20208588
107Abnormality of abdominal situs (HP:0011620)2.20208588
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19998802
109Atrioventricular block (HP:0001678)2.19733457
110Mildly elevated creatine phosphokinase (HP:0008180)2.18506175
111Ankyloglossia (HP:0010296)2.17523357
112Glioma (HP:0009733)2.17345009
113Aplasia/hypoplasia of the humerus (HP:0006507)2.16628951
114Palpitations (HP:0001962)2.13720664
115Pancreatic islet-cell hyperplasia (HP:0004510)2.13057126
116Abnormality of the pulmonary veins (HP:0011718)2.13039654
117Epileptic encephalopathy (HP:0200134)2.11724988
118Skin nodule (HP:0200036)2.09703003
119Preauricular skin tag (HP:0000384)2.08653024
120Hand muscle atrophy (HP:0009130)2.08403846
121Skin pits (HP:0100276)2.08237735
122Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.05027564
123Atrophy/Degeneration involving motor neurons (HP:0007373)2.04799430
124Shawl scrotum (HP:0000049)2.04117042
125Progressive muscle weakness (HP:0003323)2.04066224
126Malignant neoplasm of the central nervous system (HP:0100836)2.03948742
127Abnormality of the phalanges of the hallux (HP:0010057)2.02923888
128Renovascular hypertension (HP:0100817)2.01142448
129Male infertility (HP:0003251)2.00273367
130Open mouth (HP:0000194)1.99299467
131Resting tremor (HP:0002322)1.96933685
132Chromsome breakage (HP:0040012)1.96091448
133Bony spicule pigmentary retinopathy (HP:0007737)1.94591277
134Macroorchidism (HP:0000053)1.94573600
135Hyperkalemia (HP:0002153)1.94157045
136Postural instability (HP:0002172)1.93107450
137Abnormality of the calf musculature (HP:0001430)1.92704084
138Hip contracture (HP:0003273)1.92587901
139Hypopigmentation of the fundus (HP:0007894)1.92187120
140Abnormal pancreas size (HP:0012094)1.91659145
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.88948504
142Omphalocele (HP:0001539)1.87640093
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86070542
144Absent epiphyses (HP:0010577)1.86070542
145Lymphangioma (HP:0100764)1.84620694
146Skin tags (HP:0010609)1.84549998
147Angiofibromas (HP:0010615)1.84326491
148Adenoma sebaceum (HP:0009720)1.84326491
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.84082152
150Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83984749
151Renal dysplasia (HP:0000110)1.81081658
152Abnormal lung lobation (HP:0002101)1.80916890
153Aplasia/Hypoplasia of the macula (HP:0008059)1.80704115
154Mixed hearing impairment (HP:0000410)1.80595766
155Turricephaly (HP:0000262)1.80254139
156Choanal stenosis (HP:0000452)1.80036732
157Nephronophthisis (HP:0000090)1.79079804
158Papilledema (HP:0001085)1.78206346
159Truncal obesity (HP:0001956)1.77557489
160Distal upper limb amyotrophy (HP:0007149)1.76807944
161Upper limb amyotrophy (HP:0009129)1.76807944
162Drooling (HP:0002307)1.76678283
163Excessive salivation (HP:0003781)1.76678283
164Failure to thrive in infancy (HP:0001531)1.75878152
165Muscle fiber splitting (HP:0003555)1.75285467
166Trismus (HP:0000211)1.74932983
167Neuroectodermal neoplasm (HP:0030061)1.74298011
168Neuroepithelial neoplasm (HP:0030063)1.74298011
169Nervous tissue neoplasm (HP:0030060)1.74298011
170Myelomeningocele (HP:0002475)1.73907339
171Duplication of thumb phalanx (HP:0009942)1.73698006
172Menstrual irregularities (HP:0000858)1.73004699
173Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72737333
174Cutaneous finger syndactyly (HP:0010554)1.71440756
175Vertebral clefting (HP:0008428)1.71393543
176Aplasia/Hypoplasia affecting the retina (HP:0008061)1.69647642
177Ventricular fibrillation (HP:0001663)1.69046571
178Supernumerary nipples (HP:0002558)1.68297969
179Preaxial foot polydactyly (HP:0001841)1.66906466
180Bicornuate uterus (HP:0000813)1.63454173
181Anophthalmia (HP:0000528)1.59268460
182Abnormality of macular pigmentation (HP:0008002)1.58479306
183Severe Myopia (HP:0011003)1.58432385
184Cutaneous syndactyly (HP:0012725)1.58329937
185Epiphyseal dysplasia (HP:0002656)1.57843567
186Attenuation of retinal blood vessels (HP:0007843)1.56086708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.72752820
2PLK45.45163425
3GRK55.36045958
4GRK63.70269395
5ERN13.48841638
6TESK13.16339950
7TYRO33.15068697
8GRK12.89888224
9MARK12.88025821
10ADRBK22.86772706
11PNCK2.74647216
12DMPK2.50395062
13CAMK1G2.35256480
14STK38L2.34815245
15NTRK12.10243191
16WNK12.01085016
17CSF1R1.99271022
18GRK71.98131132
19CASK1.96298552
20TGFBR21.95565142
21MAP3K91.91779996
22MARK21.89303086
23PLK21.81499374
24MAPK71.73153809
25CAMK41.69640463
26NTRK21.68417459
27MATK1.66893502
28MYLK1.53332179
29TNIK1.50717483
30MAP2K41.47368117
31MAP3K101.45907352
32MOS1.40977793
33HIPK21.40974457
34CAMK1D1.35373800
35LATS21.33208174
36LATS11.31896879
37PDGFRA1.28416429
38TTK1.26030319
39FGFR31.23312515
40SIK21.22868487
41PRKG21.22527929
42MAP4K21.22222321
43PHKG21.20045899
44PHKG11.20045899
45PINK11.18359653
46NTRK31.06464762
47ADRBK11.05506578
48DYRK21.01744365
49CDK191.00499095
50ALK0.99149452
51RPS6KA20.96978121
52SIK30.95083608
53ARAF0.93188591
54PAK60.90447762
55PIK3CA0.89947023
56INSRR0.87481942
57MINK10.84977246
58EPHB20.84126792
59WNK40.82386438
60ROCK10.82060322
61FLT30.81988881
62TTN0.81467465
63STK100.80403549
64RIPK10.80184414
65SGK2230.79404163
66SGK4940.79404163
67MUSK0.78521867
68ICK0.78205185
69MAP2K60.77880741
70MAPK120.77326911
71CAMK2A0.76731006
72MAP3K70.76307858
73PAK30.75594981
74BRAF0.71834118
75MAP2K70.68024730
76UHMK10.67933398
77PRKD30.67762429
78ERBB20.65492338
79CDK70.65119911
80FGFR10.64329224
81PRKCI0.64289999
82AKT30.63961783
83FGFR20.63763947
84KSR10.63404681
85MTOR0.63317742
86AKT20.62957248
87BRD40.62168757
88PDK10.61829606
89CHEK20.61700217
90PTK20.61642536
91MAPK150.60778606
92MAP3K110.59731578
93MAP3K40.59272171
94MAP3K50.58680719
95EPHA40.58067536
96PRKCE0.56748815
97TRIB30.55125554
98PRKCG0.54445950
99LMTK20.53983392
100STK390.53814381
101CAMK2D0.53548173
102DYRK1A0.53547216
103OBSCN0.53054838
104RPS6KA10.52847412
105PRKG10.52403721
106TAOK10.51163486
107DYRK30.50484066
108PRKAA10.47662964
109PDPK10.46620487
110STK240.46349400
111PAK40.45447666
112STK380.44255431
113CDC42BPA0.43241110
114MAPK100.42327529
115CDK10.41035377
116CDK180.40911650
117RPS6KL10.40135434
118RPS6KC10.40135434
119CDK50.40134723
120CAMK10.39824946
121PRKAA20.39813703
122DDR20.37904903
123SGK20.37205057
124CDK150.36871041
125ITK0.36757433
126KSR20.36342330
127PRKCH0.36243097
128CHEK10.36102883
129BCR0.35933617
130RET0.35669922
131PKN10.35650309
132RPS6KA60.35545209
133NEK60.35446762
134CSK0.35064560
135CSNK1E0.35061067
136TIE10.34392555
137MAPK80.34312379
138PRKACB0.33341639
139PRKD20.32964251
140PRKCZ0.32684390
141CDK30.32425287
142PRKACG0.32402204
143MAPK140.32237650
144IGF1R0.31838423
145DYRK1B0.30939532
146CDK11A0.29950044
147PLK10.29335381
148GSK3B0.28661712
149CDK140.28391381
150CDK20.27596436
151RPS6KA30.27303406
152GSK3A0.24983691
153NEK10.24965133
154PRKCD0.24963439
155PKN20.24159579

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.03989758
2Vitamin B6 metabolism_Homo sapiens_hsa007503.87415383
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48685396
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.64210252
5Fructose and mannose metabolism_Homo sapiens_hsa000512.48491308
6Fatty acid biosynthesis_Homo sapiens_hsa000612.47073936
7Galactose metabolism_Homo sapiens_hsa000522.04808601
8mTOR signaling pathway_Homo sapiens_hsa041502.03363065
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94915736
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87532749
11GABAergic synapse_Homo sapiens_hsa047271.70974038
12Dilated cardiomyopathy_Homo sapiens_hsa054141.66889837
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.61977895
14Glutamatergic synapse_Homo sapiens_hsa047241.57276506
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44566910
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42378370
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38356032
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37072890
19Cardiac muscle contraction_Homo sapiens_hsa042601.36969020
20Phospholipase D signaling pathway_Homo sapiens_hsa040721.33974488
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33065391
22Arachidonic acid metabolism_Homo sapiens_hsa005901.32978791
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32527210
24Dopaminergic synapse_Homo sapiens_hsa047281.27437705
25Linoleic acid metabolism_Homo sapiens_hsa005911.24787271
26Insulin secretion_Homo sapiens_hsa049111.24175792
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.24166991
28Serotonergic synapse_Homo sapiens_hsa047261.23953138
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22429301
30Synaptic vesicle cycle_Homo sapiens_hsa047211.21976802
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20482775
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20376417
33Choline metabolism in cancer_Homo sapiens_hsa052311.18972806
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18653803
35Ovarian steroidogenesis_Homo sapiens_hsa049131.17951585
36Adherens junction_Homo sapiens_hsa045201.17025899
37Protein digestion and absorption_Homo sapiens_hsa049741.16711250
38Type II diabetes mellitus_Homo sapiens_hsa049301.14849457
39Butanoate metabolism_Homo sapiens_hsa006501.12753589
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12145933
41Circadian entrainment_Homo sapiens_hsa047131.10057674
42Long-term potentiation_Homo sapiens_hsa047201.08529068
43Basal cell carcinoma_Homo sapiens_hsa052171.08389816
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07051513
45Thyroid cancer_Homo sapiens_hsa052161.07030740
46Hippo signaling pathway_Homo sapiens_hsa043901.04503578
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03273117
48GnRH signaling pathway_Homo sapiens_hsa049121.02839959
49Axon guidance_Homo sapiens_hsa043601.02647896
50Long-term depression_Homo sapiens_hsa047301.00905566
51Hedgehog signaling pathway_Homo sapiens_hsa043401.00362640
52AMPK signaling pathway_Homo sapiens_hsa041520.99311234
53VEGF signaling pathway_Homo sapiens_hsa043700.98300138
54mRNA surveillance pathway_Homo sapiens_hsa030150.97846720
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97814618
56Oxytocin signaling pathway_Homo sapiens_hsa049210.96610374
57Gastric acid secretion_Homo sapiens_hsa049710.94214570
58Inositol phosphate metabolism_Homo sapiens_hsa005620.94052588
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.92103440
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.91209752
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.90160804
62Rap1 signaling pathway_Homo sapiens_hsa040150.89003753
63Cholinergic synapse_Homo sapiens_hsa047250.88845018
64ErbB signaling pathway_Homo sapiens_hsa040120.88432043
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88017216
66Non-small cell lung cancer_Homo sapiens_hsa052230.85280486
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.84223403
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83359489
69Calcium signaling pathway_Homo sapiens_hsa040200.83055599
70Pancreatic secretion_Homo sapiens_hsa049720.82952206
71Phenylalanine metabolism_Homo sapiens_hsa003600.82655827
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.81262606
73Fatty acid metabolism_Homo sapiens_hsa012120.80675785
74Endometrial cancer_Homo sapiens_hsa052130.79598394
75ECM-receptor interaction_Homo sapiens_hsa045120.78934951
76* Taste transduction_Homo sapiens_hsa047420.78926180
77Renin secretion_Homo sapiens_hsa049240.78598735
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78598402
79Fatty acid degradation_Homo sapiens_hsa000710.78528070
80Dorso-ventral axis formation_Homo sapiens_hsa043200.78367097
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77352292
82Nicotine addiction_Homo sapiens_hsa050330.76573409
83Notch signaling pathway_Homo sapiens_hsa043300.76385459
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75551468
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75421177
86Gap junction_Homo sapiens_hsa045400.74516927
87Oocyte meiosis_Homo sapiens_hsa041140.74136346
88Huntingtons disease_Homo sapiens_hsa050160.73628447
89Tight junction_Homo sapiens_hsa045300.73408730
90Ras signaling pathway_Homo sapiens_hsa040140.72494535
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.71676182
92* cAMP signaling pathway_Homo sapiens_hsa040240.70946599
93Morphine addiction_Homo sapiens_hsa050320.70813879
94Pathways in cancer_Homo sapiens_hsa052000.70360774
95Insulin resistance_Homo sapiens_hsa049310.69696945
96Salivary secretion_Homo sapiens_hsa049700.69283453
97Renal cell carcinoma_Homo sapiens_hsa052110.69159378
98Glioma_Homo sapiens_hsa052140.69157363
99Wnt signaling pathway_Homo sapiens_hsa043100.68799270
100Lysine degradation_Homo sapiens_hsa003100.68781076
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68551646
102MicroRNAs in cancer_Homo sapiens_hsa052060.67006387
103Cocaine addiction_Homo sapiens_hsa050300.66885675
104RNA transport_Homo sapiens_hsa030130.66524739
105Biosynthesis of amino acids_Homo sapiens_hsa012300.65490401
106Phototransduction_Homo sapiens_hsa047440.64992958
107Colorectal cancer_Homo sapiens_hsa052100.64175057
108Olfactory transduction_Homo sapiens_hsa047400.63562342
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62890677
110Focal adhesion_Homo sapiens_hsa045100.62770111
111Proteoglycans in cancer_Homo sapiens_hsa052050.62301147
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61855263
113Melanogenesis_Homo sapiens_hsa049160.61827973
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59408760
115Bile secretion_Homo sapiens_hsa049760.58753558
116Arginine and proline metabolism_Homo sapiens_hsa003300.58553897
117Carbon metabolism_Homo sapiens_hsa012000.58427232
118Pyruvate metabolism_Homo sapiens_hsa006200.58198211
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57748513
120Estrogen signaling pathway_Homo sapiens_hsa049150.55602529
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55537892
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54002197
123Insulin signaling pathway_Homo sapiens_hsa049100.53495925
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53208985
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53180657
126Circadian rhythm_Homo sapiens_hsa047100.52633297
127MAPK signaling pathway_Homo sapiens_hsa040100.51033623
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50615012
129Viral myocarditis_Homo sapiens_hsa054160.49945868
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49456656
131Amphetamine addiction_Homo sapiens_hsa050310.47344779
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46807927
133Propanoate metabolism_Homo sapiens_hsa006400.46513105
134Parkinsons disease_Homo sapiens_hsa050120.44858144
135Fat digestion and absorption_Homo sapiens_hsa049750.44565266
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43837897
137TGF-beta signaling pathway_Homo sapiens_hsa043500.42430464
138Thyroid hormone synthesis_Homo sapiens_hsa049180.42343760
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41575082
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40734066
141Glucagon signaling pathway_Homo sapiens_hsa049220.40450747

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