HCRTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.59206227
2vocalization behavior (GO:0071625)6.38035476
3positive regulation of catecholamine secretion (GO:0033605)5.57545386
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08480907
5synaptic vesicle exocytosis (GO:0016079)5.07705481
6pyrimidine nucleobase catabolic process (GO:0006208)4.97016342
7protein localization to synapse (GO:0035418)4.85877013
8serotonin receptor signaling pathway (GO:0007210)4.82885841
9presynaptic membrane assembly (GO:0097105)4.73121286
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.56420287
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52237533
12postsynaptic membrane organization (GO:0001941)4.50359960
13ganglion development (GO:0061548)4.49163304
14alkaloid metabolic process (GO:0009820)4.38166637
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.34691320
16cerebellar Purkinje cell layer development (GO:0021680)4.33290970
17neuron recognition (GO:0008038)4.29969472
18glutamate secretion (GO:0014047)4.29069110
19neuronal action potential propagation (GO:0019227)4.26673615
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25808690
21regulation of synaptic vesicle exocytosis (GO:2000300)4.25292028
22startle response (GO:0001964)4.21115074
23nucleobase catabolic process (GO:0046113)4.19839057
24neurotransmitter secretion (GO:0007269)4.16530739
25glutamate receptor signaling pathway (GO:0007215)4.16022370
26presynaptic membrane organization (GO:0097090)4.15831208
27heart field specification (GO:0003128)4.14768438
28secondary heart field specification (GO:0003139)4.14768438
29regulation of catecholamine secretion (GO:0050433)4.11295814
30retinal ganglion cell axon guidance (GO:0031290)4.09293798
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08738803
32neuron-neuron synaptic transmission (GO:0007270)4.08416452
33negative regulation of norepinephrine secretion (GO:0010700)4.08169879
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.07603006
35transmission of nerve impulse (GO:0019226)4.04532321
36negative regulation of microtubule polymerization (GO:0031115)4.02638500
37response to histamine (GO:0034776)3.94121341
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93220461
39regulation of glutamate receptor signaling pathway (GO:1900449)3.92962490
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92595191
41drinking behavior (GO:0042756)3.91197114
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87081748
43regulation of axon guidance (GO:1902667)3.85116770
44neurotransmitter-gated ion channel clustering (GO:0072578)3.83946262
45synaptic transmission, glutamatergic (GO:0035249)3.81992799
46negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.81624149
47positive regulation of synapse assembly (GO:0051965)3.80669697
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.79870922
49gamma-aminobutyric acid transport (GO:0015812)3.77831298
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.76084600
51regulation of synaptic vesicle transport (GO:1902803)3.75549814
52germ cell migration (GO:0008354)3.74053382
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.68837752
54layer formation in cerebral cortex (GO:0021819)3.68354410
55dopamine biosynthetic process (GO:0042416)3.67226453
56striatum development (GO:0021756)3.66034976
57regulation of timing of cell differentiation (GO:0048505)3.64398978
58regulation of dopamine metabolic process (GO:0042053)3.64080637
59regulation of catecholamine metabolic process (GO:0042069)3.64080637
60regulation of axon extension involved in axon guidance (GO:0048841)3.60295342
61regulation of development, heterochronic (GO:0040034)3.59133590
62central nervous system neuron axonogenesis (GO:0021955)3.58383140
63synapse assembly (GO:0007416)3.55223642
64neurotransmitter transport (GO:0006836)3.54678910
65negative regulation of dendrite morphogenesis (GO:0050774)3.54103405
66axonal fasciculation (GO:0007413)3.53472057
67dendrite development (GO:0016358)3.51206409
68exploration behavior (GO:0035640)3.50735370
69positive regulation of dendritic spine development (GO:0060999)3.49736183
70locomotory exploration behavior (GO:0035641)3.49613635
71cardiac left ventricle morphogenesis (GO:0003214)3.46608323
72proline transport (GO:0015824)3.46590373
73synaptic vesicle endocytosis (GO:0048488)3.46236991
74regulation of synapse structural plasticity (GO:0051823)3.45890813
75synaptic vesicle maturation (GO:0016188)3.45377136
76positive regulation of cardiac muscle cell differentiation (GO:2000727)3.42439630
77protein-cofactor linkage (GO:0018065)3.41850455
78regulation of neurotransmitter levels (GO:0001505)3.40851068
79somite development (GO:0061053)3.40811353
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39593623
81ATP hydrolysis coupled proton transport (GO:0015991)3.39593623
82positive regulation of calcium ion import (GO:0090280)3.39579032
83social behavior (GO:0035176)3.39119193
84intraspecies interaction between organisms (GO:0051703)3.39119193
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36133684
86transferrin transport (GO:0033572)3.35905610
87positive regulation of action potential (GO:0045760)3.34481619
88cell migration in hindbrain (GO:0021535)3.33810244
89regulation of dopamine secretion (GO:0014059)3.33702843
90epithelial cell differentiation involved in kidney development (GO:0035850)3.33448429
91regulation of synapse assembly (GO:0051963)3.33216829
92response to mineralocorticoid (GO:0051385)3.32764111
93adult walking behavior (GO:0007628)3.31700693
94positive regulation of monocyte chemotaxis (GO:0090026)3.30726424
95neurofilament cytoskeleton organization (GO:0060052)3.30108191
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29939340
97regulation of neuronal synaptic plasticity (GO:0048168)3.29931390
98behavioral response to nicotine (GO:0035095)3.29237580
99regulation of synaptic transmission, glutamatergic (GO:0051966)3.27406669
100regulation of postsynaptic membrane potential (GO:0060078)3.25189082
101regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22834356
102sympathetic nervous system development (GO:0048485)3.22374855
103G-protein coupled receptor internalization (GO:0002031)3.20208315
104cerebellar Purkinje cell differentiation (GO:0021702)3.20141612
105fear response (GO:0042596)3.17585112
106righting reflex (GO:0060013)3.17483579
107behavioral defense response (GO:0002209)3.16427091
108behavioral fear response (GO:0001662)3.16427091
109protein polyglutamylation (GO:0018095)3.16418754
110RNA destabilization (GO:0050779)3.14904100
111regulation of vesicle fusion (GO:0031338)3.14754306
112central nervous system projection neuron axonogenesis (GO:0021952)3.14171330
113parturition (GO:0007567)3.13457326
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12720512
115trivalent inorganic cation transport (GO:0072512)3.12674348
116ferric iron transport (GO:0015682)3.12674348
117auditory behavior (GO:0031223)3.12440872
118synaptic transmission, cholinergic (GO:0007271)3.12140133
119negative regulation of cAMP biosynthetic process (GO:0030818)3.11139807
120spinal cord motor neuron differentiation (GO:0021522)3.11122933
121neuromuscular synaptic transmission (GO:0007274)3.09130464
122regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09051481
123vesicle transport along microtubule (GO:0047496)3.09039693
124establishment of mitochondrion localization (GO:0051654)3.07594442
125response to insecticide (GO:0017085)3.07552657
126mechanosensory behavior (GO:0007638)3.06929987
127long-term synaptic potentiation (GO:0060291)3.06831183
128negative regulation of dendrite development (GO:2000171)3.06707668
129chaperone-mediated protein transport (GO:0072321)3.05222368
130positive regulation of amine transport (GO:0051954)3.04964966
131membrane depolarization (GO:0051899)3.04906798
132regulation of neuron migration (GO:2001222)3.01161990
133membrane hyperpolarization (GO:0060081)3.01075261
134regulation of glutamate secretion (GO:0014048)3.01041280
135membrane depolarization during action potential (GO:0086010)3.00715240
136negative regulation of catecholamine secretion (GO:0033604)3.00320970
137forebrain neuron development (GO:0021884)3.00100883
138synapse organization (GO:0050808)2.99270805
139negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.99266472
140regulation of respiratory system process (GO:0044065)2.98945682
141DNA damage response, detection of DNA damage (GO:0042769)2.98411524
142catecholamine transport (GO:0051937)2.98179068
143regulation of synaptic transmission, dopaminergic (GO:0032225)2.98073565
144regulation of respiratory gaseous exchange (GO:0043576)2.97978321
145* synaptic transmission (GO:0007268)2.97085308
146regulation of synapse organization (GO:0050807)2.96148252
147negative regulation of cAMP metabolic process (GO:0030815)2.95789970
148oxidative demethylation (GO:0070989)2.94385470
149specification of organ identity (GO:0010092)2.93986567
150negative regulation of translation, ncRNA-mediated (GO:0040033)2.93331947
151regulation of translation, ncRNA-mediated (GO:0045974)2.93331947
152negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93331947
153response to cocaine (GO:0042220)2.92040222
154synaptic transmission, dopaminergic (GO:0001963)2.91012979
155regulation of feeding behavior (GO:0060259)2.90728353
156glucocorticoid biosynthetic process (GO:0006704)2.89379678
157DNA double-strand break processing (GO:0000729)2.88894796
158dendritic spine morphogenesis (GO:0060997)2.88286859
159positive regulation of protein homodimerization activity (GO:0090073)2.87461899
160negative regulation of cyclic nucleotide metabolic process (GO:0030800)2.85372917
161hypothalamus development (GO:0021854)2.84730005
162ubiquinone metabolic process (GO:0006743)2.83058621
163calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.82496152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.46836060
2GBX2_23144817_ChIP-Seq_PC3_Human3.99531944
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.55827517
4TAF15_26573619_Chip-Seq_HEK293_Human3.47610165
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13945405
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96381673
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82076315
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76805484
9IGF1R_20145208_ChIP-Seq_DFB_Human2.65353281
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57233230
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54610397
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.52369329
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47456321
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47456321
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.45479061
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42484180
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37394791
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37284676
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34708871
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32317941
21REST_21632747_ChIP-Seq_MESCs_Mouse2.31761285
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27315278
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25915902
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25149164
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24070227
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20212371
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12205292
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12176453
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.11679951
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06472711
31AR_21572438_ChIP-Seq_LNCaP_Human1.99630204
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.97170227
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92543285
34P300_19829295_ChIP-Seq_ESCs_Human1.91899345
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.91836462
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90314378
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.87605800
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86608220
39SMAD4_21799915_ChIP-Seq_A2780_Human1.77188562
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74706604
41RNF2_27304074_Chip-Seq_NSC_Mouse1.71400230
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68378638
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67931088
44ZNF274_21170338_ChIP-Seq_K562_Hela1.66864055
45FUS_26573619_Chip-Seq_HEK293_Human1.63569779
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.60750658
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.59176763
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.59089835
49DROSHA_22980978_ChIP-Seq_HELA_Human1.56355090
50AR_25329375_ChIP-Seq_VCAP_Human1.55032228
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54273303
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42773277
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41995104
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40942579
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40232699
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.38770658
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36739614
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36456366
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.35914623
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34637241
61CBP_20019798_ChIP-Seq_JUKART_Human1.34637241
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34037891
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25469770
64ER_23166858_ChIP-Seq_MCF-7_Human1.24966289
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24021214
66JUN_21703547_ChIP-Seq_K562_Human1.22730843
67* STAT3_23295773_ChIP-Seq_U87_Human1.22521743
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21860067
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19009294
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17608668
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17418307
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17073481
73RUNX2_22187159_ChIP-Seq_PCA_Human1.15445621
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13624005
75* TCF4_23295773_ChIP-Seq_U87_Human1.13306473
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.13265285
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.12882234
78* BCAT_22108803_ChIP-Seq_LS180_Human1.11333980
79AR_19668381_ChIP-Seq_PC3_Human1.10696263
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.10468065
81* TP53_22573176_ChIP-Seq_HFKS_Human1.07386667
82* ARNT_22903824_ChIP-Seq_MCF-7_Human1.04925806
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04055724
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03250883
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.03250880
86EWS_26573619_Chip-Seq_HEK293_Human1.02818135
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02594474
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99911410
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99911410
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.99817244
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99323098
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99206644
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.97746307
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97557901
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97281220
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96135427
97KDM2B_26808549_Chip-Seq_REH_Human0.96085903
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.94440059
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92452162
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.91608339
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91195462
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90944160
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90691045
104* TP53_18474530_ChIP-ChIP_U2OS_Human0.90654589
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89319187
106VDR_22108803_ChIP-Seq_LS180_Human0.88848787
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87880941
108* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87328473
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86591671
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85852008
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.85757327
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85662798
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85627919
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.85227998
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85186477
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83073530
117P53_22387025_ChIP-Seq_ESCs_Mouse0.82900265
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82583008
119* AHR_22903824_ChIP-Seq_MCF-7_Human0.82332298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.46253213
2MP0004859_abnormal_synaptic_plasticity4.26229983
3MP0003635_abnormal_synaptic_transmissio3.62442652
4MP0009745_abnormal_behavioral_response3.48816975
5MP0006276_abnormal_autonomic_nervous3.44386707
6MP0002064_seizures3.21814428
7MP0001440_abnormal_grooming_behavior3.13973778
8MP0002063_abnormal_learning/memory/cond3.11182586
9MP0009046_muscle_twitch3.01744541
10MP0004270_analgesia2.91651259
11MP0002572_abnormal_emotion/affect_behav2.82888582
12MP0003183_abnormal_peptide_metabolism2.81218876
13MP0001968_abnormal_touch/_nociception2.68523071
14MP0001486_abnormal_startle_reflex2.65647815
15MP0005423_abnormal_somatic_nervous2.58592544
16MP0002735_abnormal_chemical_nociception2.54947751
17MP0005367_renal/urinary_system_phenotyp2.47546228
18MP0000516_abnormal_urinary_system2.47546228
19MP0002734_abnormal_mechanical_nocicepti2.44135449
20MP0002272_abnormal_nervous_system2.41797701
21MP0003122_maternal_imprinting2.37297088
22MP0001529_abnormal_vocalization2.32893061
23* MP0001501_abnormal_sleep_pattern2.32843295
24MP0002733_abnormal_thermal_nociception2.26409188
25MP0002736_abnormal_nociception_after2.14345829
26MP0002067_abnormal_sensory_capabilities2.12336100
27MP0001970_abnormal_pain_threshold2.11438276
28MP0002184_abnormal_innervation1.97322327
29MP0001905_abnormal_dopamine_level1.95669089
30MP0002822_catalepsy1.94658688
31MP0002557_abnormal_social/conspecific_i1.93367829
32MP0003890_abnormal_embryonic-extraembry1.90036710
33MP0001188_hyperpigmentation1.86663037
34MP0000778_abnormal_nervous_system1.75520124
35MP0004142_abnormal_muscle_tone1.75134256
36MP0003787_abnormal_imprinting1.71458472
37MP0010386_abnormal_urinary_bladder1.70464568
38MP0002837_dystrophic_cardiac_calcinosis1.65851792
39MP0004924_abnormal_behavior1.62292675
40MP0005386_behavior/neurological_phenoty1.62292675
41MP0006292_abnormal_olfactory_placode1.60511910
42MP0005646_abnormal_pituitary_gland1.54885590
43MP0008995_early_reproductive_senescence1.53944810
44MP0005187_abnormal_penis_morphology1.53329096
45MP0004811_abnormal_neuron_physiology1.52051101
46MP0003329_amyloid_beta_deposits1.51050735
47MP0005645_abnormal_hypothalamus_physiol1.49441334
48MP0009278_abnormal_bone_marrow1.44097214
49MP0000955_abnormal_spinal_cord1.41784959
50MP0002066_abnormal_motor_capabilities/c1.38624701
51MP0003121_genomic_imprinting1.34278276
52MP0003879_abnormal_hair_cell1.30368515
53MP0002909_abnormal_adrenal_gland1.28608311
54MP0005647_abnormal_sex_gland1.26626912
55MP0002882_abnormal_neuron_morphology1.26545741
56MP0008569_lethality_at_weaning1.25852460
57MP0003718_maternal_effect1.25447886
58MP0002163_abnormal_gland_morphology1.24418732
59MP0000751_myopathy1.23677397
60MP0000569_abnormal_digit_pigmentation1.23213202
61MP0003011_delayed_dark_adaptation1.22584555
62MP0002638_abnormal_pupillary_reflex1.21000601
63MP0003123_paternal_imprinting1.20692788
64MP0002876_abnormal_thyroid_physiology1.19926176
65MP0002102_abnormal_ear_morphology1.19190105
66MP0001984_abnormal_olfaction1.18773195
67MP0002653_abnormal_ependyma_morphology1.14354645
68MP0009780_abnormal_chondrocyte_physiolo1.13535158
69MP0000534_abnormal_ureter_morphology1.10503095
70MP0000372_irregular_coat_pigmentation1.09434040
71MP0001664_abnormal_digestion1.08613714
72MP0004742_abnormal_vestibular_system1.08475882
73MP0001502_abnormal_circadian_rhythm1.06909077
74MP0005379_endocrine/exocrine_gland_phen1.01449335
75MP0002152_abnormal_brain_morphology0.99822251
76MP0003690_abnormal_glial_cell0.99295288
77MP0001879_abnormal_lymphatic_vessel0.97025068
78MP0002234_abnormal_pharynx_morphology0.94999627
79MP0008872_abnormal_physiological_respon0.94941788
80MP0005503_abnormal_tendon_morphology0.94553621
81MP0004085_abnormal_heartbeat0.92558561
82MP0004858_abnormal_nervous_system0.91558838
83MP0001986_abnormal_taste_sensitivity0.91429479
84MP0005535_abnormal_body_temperature0.91037823
85MP0001919_abnormal_reproductive_system0.89926031
86MP0008961_abnormal_basal_metabolism0.89141310
87MP0004145_abnormal_muscle_electrophysio0.88824497
88MP0002069_abnormal_eating/drinking_beha0.88064929
89MP0004133_heterotaxia0.87800392
90MP0008874_decreased_physiological_sensi0.85847051
91MP0001177_atelectasis0.85791897
92MP0000013_abnormal_adipose_tissue0.85353821
93MP0002282_abnormal_trachea_morphology0.85268483
94MP0004147_increased_porphyrin_level0.83537690
95MP0005253_abnormal_eye_physiology0.82168082
96MP0002160_abnormal_reproductive_system0.81280897
97MP0008877_abnormal_DNA_methylation0.80792342
98MP0005551_abnormal_eye_electrophysiolog0.80606131
99MP0002229_neurodegeneration0.79895427
100MP0003861_abnormal_nervous_system0.79764781
101MP0005389_reproductive_system_phenotype0.79447029
102MP0003137_abnormal_impulse_conducting0.79314796
103MP0000538_abnormal_urinary_bladder0.79091856
104MP0002751_abnormal_autonomic_nervous0.78059297
105MP0003119_abnormal_digestive_system0.74328882
106MP0000462_abnormal_digestive_system0.74104879
107MP0001963_abnormal_hearing_physiology0.74043648
108MP0005397_hematopoietic_system_phenotyp0.73510178
109MP0001545_abnormal_hematopoietic_system0.73510178
110MP0004233_abnormal_muscle_weight0.73466028
111MP0002752_abnormal_somatic_nervous0.73166773
112MP0008770_decreased_survivor_rate0.73163010
113MP0003633_abnormal_nervous_system0.73015276
114MP0003631_nervous_system_phenotype0.72285532
115MP0004885_abnormal_endolymph0.69242904
116MP0002127_abnormal_cardiovascular_syste0.68794247
117MP0003567_abnormal_fetal_cardiomyocyte0.67379504
118MP0000604_amyloidosis0.66729825
119MP0000015_abnormal_ear_pigmentation0.66532324
120MP0000631_abnormal_neuroendocrine_gland0.66229756
121MP0001299_abnormal_eye_distance/0.63037943
122MP0010768_mortality/aging0.61452482
123MP0001943_abnormal_respiration0.60844711
124MP0000049_abnormal_middle_ear0.58881171
125MP0010770_preweaning_lethality0.57397650
126MP0002082_postnatal_lethality0.57397650
127MP0003632_abnormal_nervous_system0.57326738
128MP0005623_abnormal_meninges_morphology0.57192443
129MP0002332_abnormal_exercise_endurance0.55988009
130MP0003634_abnormal_glial_cell0.54339251
131MP0000747_muscle_weakness0.52587277
132MP0003956_abnormal_body_size0.51729458
133MP0010769_abnormal_survival0.51359130

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.11429326
2Myokymia (HP:0002411)6.31354315
3Febrile seizures (HP:0002373)5.62083923
4Focal seizures (HP:0007359)5.59983295
5Atonic seizures (HP:0010819)4.94160671
6Epileptic encephalopathy (HP:0200134)4.88318889
7Limb dystonia (HP:0002451)4.81365942
8Progressive cerebellar ataxia (HP:0002073)4.28776685
9Hyperventilation (HP:0002883)4.15663539
10Broad alveolar ridges (HP:0000187)4.14242383
11Absence seizures (HP:0002121)4.09304480
12Generalized tonic-clonic seizures (HP:0002069)4.05412761
13Dialeptic seizures (HP:0011146)4.03619435
14Visual hallucinations (HP:0002367)3.93179556
15Drooling (HP:0002307)3.79118384
16Excessive salivation (HP:0003781)3.79118384
17Failure to thrive in infancy (HP:0001531)3.75597748
18Broad-based gait (HP:0002136)3.75104100
19Adactyly (HP:0009776)3.73703015
20Abnormal hair whorl (HP:0010721)3.52179915
21Neonatal respiratory distress (HP:0002643)3.48682249
22Pheochromocytoma (HP:0002666)3.40644336
23Polyphagia (HP:0002591)3.31222609
24Chronic hepatic failure (HP:0100626)3.13961551
25Poor suck (HP:0002033)3.12009467
26Neuroendocrine neoplasm (HP:0100634)3.07770976
27Fair hair (HP:0002286)3.07220123
28Spastic gait (HP:0002064)3.04297406
29Protruding tongue (HP:0010808)3.01531036
30Amyotrophic lateral sclerosis (HP:0007354)3.00954671
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.85140040
32Abnormal eating behavior (HP:0100738)2.79087127
33Exotropia (HP:0000577)2.77102768
34Hypothermia (HP:0002045)2.75920422
35Abnormal social behavior (HP:0012433)2.70014900
36Impaired social interactions (HP:0000735)2.70014900
37Long foot (HP:0001833)2.69936174
38High anterior hairline (HP:0009890)2.68885852
39Epileptiform EEG discharges (HP:0011182)2.68870421
40Generalized hypopigmentation of hair (HP:0011358)2.67598314
41Lissencephaly (HP:0001339)2.65855892
42Abnormality of the corticospinal tract (HP:0002492)2.65337258
43Spastic tetraplegia (HP:0002510)2.64235625
44Resting tremor (HP:0002322)2.63816735
45Esotropia (HP:0000565)2.61931216
46Gaze-evoked nystagmus (HP:0000640)2.61558202
47Mutism (HP:0002300)2.59994155
48Termporal pattern (HP:0011008)2.58735786
49Insidious onset (HP:0003587)2.58735786
50Pachygyria (HP:0001302)2.58195865
51Abnormality of salivation (HP:0100755)2.56649118
52Severe global developmental delay (HP:0011344)2.56647208
53Progressive inability to walk (HP:0002505)2.54794413
54Absent speech (HP:0001344)2.53985015
55Impaired vibration sensation in the lower limbs (HP:0002166)2.52637996
56Fetal akinesia sequence (HP:0001989)2.51336334
57Amblyopia (HP:0000646)2.50610539
58Blue irides (HP:0000635)2.49467555
59Torticollis (HP:0000473)2.49135263
60Sleep apnea (HP:0010535)2.47553018
61Truncal ataxia (HP:0002078)2.46446459
62Synostosis involving the elbow (HP:0003938)2.45104820
63Humeroradial synostosis (HP:0003041)2.45104820
64EEG with generalized epileptiform discharges (HP:0011198)2.45057249
65Depression (HP:0000716)2.41344471
66Akinesia (HP:0002304)2.40704364
67Hypoventilation (HP:0002791)2.38574676
68Renal hypoplasia (HP:0000089)2.36989200
69Hepatoblastoma (HP:0002884)2.36590700
70Growth hormone deficiency (HP:0000824)2.36202326
71Acute necrotizing encephalopathy (HP:0006965)2.35573366
72Anxiety (HP:0000739)2.34805854
73Abnormality of the lower motor neuron (HP:0002366)2.33483577
74Narrow forehead (HP:0000341)2.31499387
75Oligomenorrhea (HP:0000876)2.31444964
76Hypsarrhythmia (HP:0002521)2.30750240
77Delayed gross motor development (HP:0002194)2.29894840
78Focal dystonia (HP:0004373)2.28851793
79Abnormality of the labia minora (HP:0012880)2.28708016
80Hemiparesis (HP:0001269)2.26276610
81Status epilepticus (HP:0002133)2.24068991
82Craniofacial dystonia (HP:0012179)2.23179932
83Cortical dysplasia (HP:0002539)2.23104901
84True hermaphroditism (HP:0010459)2.20952746
85Specific learning disability (HP:0001328)2.20269867
86Hypoplasia of the brainstem (HP:0002365)2.18474384
87Aplasia/Hypoplasia of the brainstem (HP:0007362)2.18474384
88Sensory axonal neuropathy (HP:0003390)2.15212118
89Retinal dysplasia (HP:0007973)2.14460462
90Dysdiadochokinesis (HP:0002075)2.12930440
91Bradykinesia (HP:0002067)2.12682682
92Poor eye contact (HP:0000817)2.12471090
93Abnormality of binocular vision (HP:0011514)2.11933124
94Diplopia (HP:0000651)2.11933124
95Hyperthyroidism (HP:0000836)2.10595785
96Progressive macrocephaly (HP:0004481)2.09951735
97Abnormal mitochondria in muscle tissue (HP:0008316)2.09685429
98Action tremor (HP:0002345)2.09129628
99Molar tooth sign on MRI (HP:0002419)2.09021429
100Abnormality of midbrain morphology (HP:0002418)2.09021429
101Urinary urgency (HP:0000012)2.08763670
102Agitation (HP:0000713)2.08435344
103Methylmalonic acidemia (HP:0002912)2.08187989
104Increased intramyocellular lipid droplets (HP:0012240)2.06358543
105Hypoplastic pelvis (HP:0008839)2.05358762
106Increased hepatocellular lipid droplets (HP:0006565)2.05106587
107Neoplasm of the heart (HP:0100544)2.04609727
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04597376
109Clumsiness (HP:0002312)2.04346482
110Pancreatic cysts (HP:0001737)2.02223086
111Supranuclear gaze palsy (HP:0000605)2.01972750
112Inability to walk (HP:0002540)2.00643367
113Lipid accumulation in hepatocytes (HP:0006561)2.00528114
114Medulloblastoma (HP:0002885)2.00078304
115Generalized myoclonic seizures (HP:0002123)1.98871971
116Gait imbalance (HP:0002141)1.98472373
117Pancreatic fibrosis (HP:0100732)1.97989701
118Urinary bladder sphincter dysfunction (HP:0002839)1.96655401
119Postural instability (HP:0002172)1.96403888
120Gait ataxia (HP:0002066)1.95982340
121Narrow nasal bridge (HP:0000446)1.95718684
122Dysmetria (HP:0001310)1.94989478
123Mitochondrial inheritance (HP:0001427)1.93380719
124Osteomalacia (HP:0002749)1.89401797
125Genetic anticipation (HP:0003743)1.87605017
126Abnormality of the alveolar ridges (HP:0006477)1.87134221
127Diminished movement (HP:0002374)1.86975904
128Incomplete penetrance (HP:0003829)1.85705427
129Papilledema (HP:0001085)1.84829170
130Shoulder girdle muscle weakness (HP:0003547)1.84498173
131Intellectual disability, mild (HP:0001256)1.84315027
132Psychosis (HP:0000709)1.82793320
133Dysmetric saccades (HP:0000641)1.80882509
134Inappropriate behavior (HP:0000719)1.79838307
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.79459899
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79459899
137Aqueductal stenosis (HP:0002410)1.79144264
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78925056
139Ankle clonus (HP:0011448)1.78879719
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.78071808
141Increased muscle lipid content (HP:0009058)1.78044199
142Acute encephalopathy (HP:0006846)1.76722818
143Renal Fanconi syndrome (HP:0001994)1.76673776
144Spastic tetraparesis (HP:0001285)1.76613771
145Sclerocornea (HP:0000647)1.74474364
146Abnormality of the musculature of the pelvis (HP:0001469)1.74253465
147Abnormality of the hip-girdle musculature (HP:0001445)1.74253465
148Prominent supraorbital ridges (HP:0000336)1.70621250
149Abnormal number of incisors (HP:0011064)1.67727321
150Rhinitis (HP:0012384)1.66754043
151Abnormal respiratory epithelium morphology (HP:0012253)1.66569847
152Abnormal respiratory motile cilium morphology (HP:0005938)1.66569847
153Abnormal EKG (HP:0003115)1.66335701
154Morphological abnormality of the pyramidal tract (HP:0002062)1.65372930
155Split foot (HP:0001839)1.65229871
156Medial flaring of the eyebrow (HP:0010747)1.63112330
157Pelvic girdle muscle weakness (HP:0003749)1.62753136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.54652410
2CASK4.87047336
3PRKD34.34699945
4MAP3K43.86307052
5MAP2K73.57641038
6NTRK33.35397789
7MAP3K122.98527156
8MINK12.87319582
9SIK22.76979909
10CLK12.72302505
11MARK12.69935003
12MAP2K42.50661913
13BCR2.43693940
14TSSK62.21537174
15FRK2.21259690
16FGFR32.11839776
17NTRK21.87744590
18PLK21.81023451
19GRK51.78161928
20EPHA41.72457082
21MAP3K91.67087737
22CDK191.61127034
23KSR11.59281677
24PINK11.58584045
25MAPK131.58297181
26PNCK1.57849187
27SRPK11.52115018
28PAK61.51284592
29RIPK41.49057232
30MAP4K21.34914254
31UHMK11.32837171
32CAMK2A1.29806202
33TNIK1.24267672
34CDK51.22895799
35PRKCG1.18669613
36NME11.09708994
37MAPK41.04724614
38OXSR11.03778319
39NTRK10.99665507
40CAMK40.99649760
41CAMK2B0.96589315
42PTK2B0.96512537
43CCNB10.94400377
44CSNK1G20.94373614
45AKT30.92709976
46FES0.91937889
47IRAK20.91629620
48TAF10.91199966
49LATS20.90618736
50FGR0.90242571
51MAPK150.88232769
52DAPK10.86933802
53BMPR1B0.85690834
54CDK180.85077484
55PHKG10.84543119
56PHKG20.84543119
57SGK20.76443973
58CSNK1G30.75650287
59TAOK10.74546698
60WNK30.73083626
61RET0.72966133
62SGK4940.72509719
63SGK2230.72509719
64MAPKAPK50.72123748
65BMPR20.71725515
66PASK0.71667618
67DAPK20.71615447
68MAP3K60.68780616
69BCKDK0.68556248
70PRKCE0.68418543
71CAMK2D0.67678562
72PRPF4B0.67656105
73TIE10.67557261
74CDK140.65533465
75CDK80.65195300
76CAMK2G0.63522200
77ERBB40.62605548
78CDK150.62396983
79CDK30.61893508
80MYLK0.60185010
81CSNK1A1L0.60158343
82ARAF0.57361086
83DYRK1A0.56666848
84MAPK90.54073873
85PKN10.54071580
86DYRK20.53799262
87FER0.53723391
88LIMK10.52005324
89RPS6KA20.51858805
90GRK60.50830202
91CDK11A0.49333217
92ADRBK10.48838187
93MAP3K70.46683951
94DYRK30.45023645
95EPHB20.44828275
96ERBB30.44225756
97PAK30.43124213
98FYN0.43123227
99SGK10.41664030
100TGFBR10.41140510
101ADRBK20.40397417
102MARK20.40387896
103GRK70.40305666
104VRK10.38628648
105CSNK1G10.37902197
106PRKACB0.37831304
107INSRR0.37481132
108MKNK20.36819324
109STK160.36683119
110PRKACA0.36473991
111TAOK30.36440377
112ERBB20.36389013
113CAMK10.35906879
114CSNK1A10.35792751
115PRKCH0.35539523
116PRKCB0.35444128
117RPS6KA30.35343121
118PAK10.35318385
119TGFBR20.34680255
120SGK30.32744365
121CAMKK20.31859998
122SIK10.31769275
123PRKACG0.31653056
124PRKCA0.31641797
125GSK3B0.31576893
126CSNK1E0.31338002
127PRKCZ0.29529857
128PRKG10.28961117
129STK110.27177838
130CAMKK10.27009984
131CDC42BPA0.26482769
132SRC0.26274681
133MAPK70.26242490
134IRAK10.25905550
135MAPK120.25781486

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.66838121
2Synaptic vesicle cycle_Homo sapiens_hsa047213.92645667
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.18210761
4Collecting duct acid secretion_Homo sapiens_hsa049663.05574057
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81087866
6GABAergic synapse_Homo sapiens_hsa047272.60806727
7Amphetamine addiction_Homo sapiens_hsa050312.48389877
8Dopaminergic synapse_Homo sapiens_hsa047282.37459358
9Morphine addiction_Homo sapiens_hsa050322.31020689
10Circadian entrainment_Homo sapiens_hsa047132.30842646
11Glutamatergic synapse_Homo sapiens_hsa047242.28745516
12Serotonergic synapse_Homo sapiens_hsa047262.24793775
13Olfactory transduction_Homo sapiens_hsa047402.24498104
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.24250889
15Oxidative phosphorylation_Homo sapiens_hsa001902.20031898
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11217696
17Taste transduction_Homo sapiens_hsa047422.08672561
18Long-term potentiation_Homo sapiens_hsa047202.07043525
19Cocaine addiction_Homo sapiens_hsa050301.93574160
20Vibrio cholerae infection_Homo sapiens_hsa051101.85755972
21Cholinergic synapse_Homo sapiens_hsa047251.79843357
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75816802
23Insulin secretion_Homo sapiens_hsa049111.73653074
24Long-term depression_Homo sapiens_hsa047301.70859087
25* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67612939
26Salivary secretion_Homo sapiens_hsa049701.66898567
27Parkinsons disease_Homo sapiens_hsa050121.66252939
28Renin secretion_Homo sapiens_hsa049241.61924226
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.58739551
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58474410
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50806182
32Calcium signaling pathway_Homo sapiens_hsa040201.48895358
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44819709
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41372183
35Alzheimers disease_Homo sapiens_hsa050101.40371927
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39480278
37Axon guidance_Homo sapiens_hsa043601.28871232
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27487065
39Gastric acid secretion_Homo sapiens_hsa049711.27013399
40Folate biosynthesis_Homo sapiens_hsa007901.26869872
41Cardiac muscle contraction_Homo sapiens_hsa042601.24774437
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22566967
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22104049
44Gap junction_Homo sapiens_hsa045401.17310422
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16024655
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15876115
47Oxytocin signaling pathway_Homo sapiens_hsa049211.13084886
48Propanoate metabolism_Homo sapiens_hsa006401.13019487
49cAMP signaling pathway_Homo sapiens_hsa040241.11792703
50GnRH signaling pathway_Homo sapiens_hsa049121.08318923
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07415175
52Selenocompound metabolism_Homo sapiens_hsa004501.02519144
53Phototransduction_Homo sapiens_hsa047440.94704965
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.94055067
55Protein export_Homo sapiens_hsa030600.91590232
56Rheumatoid arthritis_Homo sapiens_hsa053230.90266452
57ErbB signaling pathway_Homo sapiens_hsa040120.84722665
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84250258
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.83590460
60Phagosome_Homo sapiens_hsa041450.83410301
61Huntingtons disease_Homo sapiens_hsa050160.82076237
62Type I diabetes mellitus_Homo sapiens_hsa049400.81811214
63Estrogen signaling pathway_Homo sapiens_hsa049150.81705521
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79778282
65Type II diabetes mellitus_Homo sapiens_hsa049300.79430922
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76458860
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72601200
68Circadian rhythm_Homo sapiens_hsa047100.71591315
69Chemical carcinogenesis_Homo sapiens_hsa052040.70840915
70Melanogenesis_Homo sapiens_hsa049160.70684516
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70017271
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69847452
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67933175
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67372137
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65960338
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62978743
77Oocyte meiosis_Homo sapiens_hsa041140.62830220
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.62563698
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62236601
80Butanoate metabolism_Homo sapiens_hsa006500.61637336
81Linoleic acid metabolism_Homo sapiens_hsa005910.61431890
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61065918
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56780810
84Thyroid hormone synthesis_Homo sapiens_hsa049180.54725227
85Retinol metabolism_Homo sapiens_hsa008300.54525342
86Glucagon signaling pathway_Homo sapiens_hsa049220.52257323
87Sulfur relay system_Homo sapiens_hsa041220.51438823
88Pyruvate metabolism_Homo sapiens_hsa006200.51406434
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48188929
90Glioma_Homo sapiens_hsa052140.48116803
91Histidine metabolism_Homo sapiens_hsa003400.46680601
92MAPK signaling pathway_Homo sapiens_hsa040100.42974956
93Proteasome_Homo sapiens_hsa030500.42598859
94Pancreatic secretion_Homo sapiens_hsa049720.41591673
95Salmonella infection_Homo sapiens_hsa051320.41011038
96Metabolic pathways_Homo sapiens_hsa011000.40942427
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40892146
98Alcoholism_Homo sapiens_hsa050340.40006135
99Ras signaling pathway_Homo sapiens_hsa040140.39150807
100Choline metabolism in cancer_Homo sapiens_hsa052310.38908449
101Dilated cardiomyopathy_Homo sapiens_hsa054140.37944590
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.37928766
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.34861950
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34653421
105Steroid biosynthesis_Homo sapiens_hsa001000.34605736
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34119098
107Tryptophan metabolism_Homo sapiens_hsa003800.32954921
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.32346042
109Phenylalanine metabolism_Homo sapiens_hsa003600.32097862
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31879852
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31490676
112Hedgehog signaling pathway_Homo sapiens_hsa043400.31278252
113AMPK signaling pathway_Homo sapiens_hsa041520.31147556
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31059936
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31044907
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30544772
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29089265
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28935189
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.27430492
120African trypanosomiasis_Homo sapiens_hsa051430.26894225
121Insulin signaling pathway_Homo sapiens_hsa049100.25976879
122Tyrosine metabolism_Homo sapiens_hsa003500.25721864
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23942446
124Rap1 signaling pathway_Homo sapiens_hsa040150.23936545
125N-Glycan biosynthesis_Homo sapiens_hsa005100.23760867
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23568212
127Bile secretion_Homo sapiens_hsa049760.22900053
128Arginine biosynthesis_Homo sapiens_hsa002200.22458796
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.21944265
130Dorso-ventral axis formation_Homo sapiens_hsa043200.21915982
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21651880
132Ether lipid metabolism_Homo sapiens_hsa005650.20935218
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19953186
134Ovarian steroidogenesis_Homo sapiens_hsa049130.19735702
135Wnt signaling pathway_Homo sapiens_hsa043100.17679304

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