HCST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92525974
2positive regulation of gamma-delta T cell activation (GO:0046645)5.87800685
3leukocyte aggregation (GO:0070486)5.76464995
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.29535037
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.29535037
6negative T cell selection (GO:0043383)5.22204215
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.10216869
8negative thymic T cell selection (GO:0045060)5.09805156
9T cell migration (GO:0072678)4.98591762
10cytidine deamination (GO:0009972)4.95330045
11cytidine metabolic process (GO:0046087)4.95330045
12cytidine catabolic process (GO:0006216)4.95330045
13regulation of B cell receptor signaling pathway (GO:0050855)4.95062843
14interferon-gamma production (GO:0032609)4.88394617
15negative regulation of cell killing (GO:0031342)4.81399072
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81399072
17antigen processing and presentation of endogenous antigen (GO:0019883)4.64209705
18positive thymic T cell selection (GO:0045059)4.50934097
19regulation of isotype switching to IgG isotypes (GO:0048302)4.47889458
20regulation of gamma-delta T cell differentiation (GO:0045586)4.44872701
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.33628642
22mast cell activation (GO:0045576)4.33515434
23regulation of gamma-delta T cell activation (GO:0046643)4.14822040
24sequestering of actin monomers (GO:0042989)4.11789782
25thymic T cell selection (GO:0045061)4.10042635
26DNA deamination (GO:0045006)4.09249668
27ribosomal small subunit assembly (GO:0000028)4.07552749
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00117715
29cellular response to interleukin-15 (GO:0071350)3.99007778
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.95435793
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91146745
32positive T cell selection (GO:0043368)3.88409010
33response to interleukin-15 (GO:0070672)3.82868142
34respiratory burst (GO:0045730)3.76797896
35neutrophil activation involved in immune response (GO:0002283)3.74885280
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.74486475
37cellular response to zinc ion (GO:0071294)3.71599043
38negative regulation of interleukin-12 production (GO:0032695)3.71203394
39T cell selection (GO:0045058)3.70974904
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69183757
41regulation of regulatory T cell differentiation (GO:0045589)3.65993515
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.65844647
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64685353
44regulation of B cell differentiation (GO:0045577)3.64499738
45regulation of activation of Janus kinase activity (GO:0010533)3.63567945
46regulation of alpha-beta T cell proliferation (GO:0046640)3.62095528
47regulation of T cell receptor signaling pathway (GO:0050856)3.59162826
48cellular response to type I interferon (GO:0071357)3.56964652
49type I interferon signaling pathway (GO:0060337)3.56964652
50positive regulation of isotype switching (GO:0045830)3.56908206
51response to type I interferon (GO:0034340)3.56498285
52lymphocyte chemotaxis (GO:0048247)3.52796713
53T cell receptor signaling pathway (GO:0050852)3.52574368
54positive regulation of B cell mediated immunity (GO:0002714)3.48867941
55positive regulation of immunoglobulin mediated immune response (GO:0002891)3.48867941
56regulation of natural killer cell mediated immunity (GO:0002715)3.46390978
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.46390978
58T cell costimulation (GO:0031295)3.45431807
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.45409027
60positive regulation of natural killer cell mediated immunity (GO:0002717)3.45409027
61antigen processing and presentation via MHC class Ib (GO:0002475)3.42737008
62lymphocyte costimulation (GO:0031294)3.41931165
63immunoglobulin mediated immune response (GO:0016064)3.41107818
64defense response to protozoan (GO:0042832)3.40568831
65antigen receptor-mediated signaling pathway (GO:0050851)3.39575255
66regulation of tolerance induction (GO:0002643)3.34421285
67positive regulation of calcium-mediated signaling (GO:0050850)3.33083764
68macrophage activation involved in immune response (GO:0002281)3.32915453
69leukocyte cell-cell adhesion (GO:0007159)3.32801581
70B cell receptor signaling pathway (GO:0050853)3.30201125
71response to protozoan (GO:0001562)3.28958786
72myeloid cell activation involved in immune response (GO:0002275)3.26809674
73regulation of B cell mediated immunity (GO:0002712)3.24648227
74regulation of immunoglobulin mediated immune response (GO:0002889)3.21491577
75interferon-gamma-mediated signaling pathway (GO:0060333)3.18766288
76regulation of T cell tolerance induction (GO:0002664)3.17661866
77positive regulation of DNA recombination (GO:0045911)3.16474100
78cellular extravasation (GO:0045123)3.16421624
79macrophage chemotaxis (GO:0048246)3.16300239
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.15178988
81regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14036225
82neutrophil activation (GO:0042119)3.13612651
83negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13350165
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12058322
85cellular defense response (GO:0006968)3.09942590
86regulation of response to interferon-gamma (GO:0060330)3.09755802
87positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09561693
88natural killer cell activation (GO:0030101)3.06827633
89negative regulation of leukocyte mediated immunity (GO:0002704)3.05805461
90negative regulation of viral genome replication (GO:0045071)3.04791585
91positive regulation of mast cell activation (GO:0033005)3.03966105
92positive regulation of monocyte chemotaxis (GO:0090026)3.02601542
93regulation of isotype switching (GO:0045191)3.02282834
94myeloid dendritic cell activation (GO:0001773)3.01969970
95B cell mediated immunity (GO:0019724)3.01511379
96lymphocyte migration (GO:0072676)3.01317163
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00757381
98negative regulation of phagocytosis (GO:0050765)3.00369095
99regulation of antigen processing and presentation (GO:0002577)3.00279024
100positive regulation of macrophage differentiation (GO:0045651)2.99025655
101negative regulation of T cell apoptotic process (GO:0070233)2.98790120
102positive regulation of antigen processing and presentation (GO:0002579)2.98342420
103mast cell degranulation (GO:0043303)2.97790994
104mast cell activation involved in immune response (GO:0002279)2.97790994
105NIK/NF-kappaB signaling (GO:0038061)2.96905607
106positive regulation of lymphocyte migration (GO:2000403)2.96692679
107negative regulation of T cell receptor signaling pathway (GO:0050860)2.96324054
108positive regulation of lamellipodium assembly (GO:0010592)2.96075698
109regulation of T cell mediated cytotoxicity (GO:0001914)2.95718325
110viral transcription (GO:0019083)2.95520665
111granulocyte activation (GO:0036230)2.94671553
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.94443869
113detection of bacterium (GO:0016045)2.94054006
114regulation of lymphocyte chemotaxis (GO:1901623)2.92830697
115cellular response to interferon-beta (GO:0035458)2.91276583
116response to interferon-beta (GO:0035456)2.91041275
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.90801922
118actin nucleation (GO:0045010)2.88121043
119regulation of cell killing (GO:0031341)2.87974409
120response to peptidoglycan (GO:0032494)2.87959604
121leukocyte degranulation (GO:0043299)2.86722960
122detection of other organism (GO:0098543)2.86381571
123regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86366001
124positive regulation of B cell differentiation (GO:0045579)2.86201609
125regulation of chronic inflammatory response (GO:0002676)2.85824816
126modulation by symbiont of host immune response (GO:0052553)2.85641734
127positive regulation by symbiont of host defense response (GO:0052509)2.85641734
128modulation by symbiont of host defense response (GO:0052031)2.85641734
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85641734
130modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85641734
131positive regulation by organism of defense response of other organism involved in symbiotic interact2.85641734
132positive regulation of cell killing (GO:0031343)2.82997017
133translational termination (GO:0006415)2.79751902
134positive regulation of tolerance induction (GO:0002645)2.78099832
135positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78032398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05569804
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.99165213
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.36356271
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.25456190
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.00813629
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.54034182
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52486932
8E2F7_22180533_ChIP-Seq_HELA_Human3.50652802
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46240513
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.24512429
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12584155
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.00938763
13* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87325746
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72257111
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66172830
16MYB_26560356_Chip-Seq_TH2_Human2.65682859
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56860457
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56035715
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52985847
20RUNX_20019798_ChIP-Seq_JUKART_Human2.51829938
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.51070562
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.49242943
23* SPI1_23547873_ChIP-Seq_NB4_Human2.48980391
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41540348
25SCL_19346495_ChIP-Seq_HPC-7_Human2.38368475
26MAF_26560356_Chip-Seq_TH1_Human2.32342087
27MYC_22102868_ChIP-Seq_BL_Human2.27436921
28MYB_26560356_Chip-Seq_TH1_Human2.21291820
29* RUNX1_22412390_ChIP-Seq_EML_Mouse2.07344888
30* UTX_26944678_Chip-Seq_JUKART_Human2.02661320
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97849248
32VDR_21846776_ChIP-Seq_THP-1_Human1.96975699
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.93280937
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91600352
35* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91455152
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.89471960
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89018712
38VDR_24763502_ChIP-Seq_THP-1_Human1.84385019
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82773681
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81422660
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75105265
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69566003
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64417221
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62678459
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62339770
46GATA3_27048872_Chip-Seq_THYMUS_Human1.58300793
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56548098
48MAF_26560356_Chip-Seq_TH2_Human1.56511803
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50784931
50VDR_23849224_ChIP-Seq_CD4+_Human1.50574228
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.46047779
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44692085
53BCL6_27268052_Chip-Seq_Bcells_Human1.44576883
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41528352
55* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40204808
56PU_27001747_Chip-Seq_BMDM_Mouse1.40175412
57* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35525953
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34054942
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32340089
60FOXP3_21729870_ChIP-Seq_TREG_Human1.32330568
61VDR_24787735_ChIP-Seq_THP-1_Human1.30997386
62* SPI1_23127762_ChIP-Seq_K562_Human1.28891010
63TCF7_22412390_ChIP-Seq_EML_Mouse1.27115404
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26741491
65* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25371538
66GATA3_26560356_Chip-Seq_TH2_Human1.22979480
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21811800
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21673674
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.21158107
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21028083
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18954560
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18677033
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14735412
74BCOR_27268052_Chip-Seq_Bcells_Human1.13328166
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12220786
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11678946
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.11176733
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11078612
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10249552
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10248563
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09119186
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08137002
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06606765
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05320699
85ELK1_19687146_ChIP-ChIP_HELA_Human1.05149562
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04279781
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03535799
88MYC_18555785_ChIP-Seq_MESCs_Mouse1.03322821
89STAT1_20625510_ChIP-Seq_HELA_Human1.02746821
90SPI1_20517297_ChIP-Seq_HL60_Human1.02214031
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01715958
92P300_27268052_Chip-Seq_Bcells_Human1.01319765
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99898545
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97411099
95CIITA_25753668_ChIP-Seq_RAJI_Human0.97394136
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.95930703
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95911169
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93956058
99LXR_22292898_ChIP-Seq_THP-1_Human0.93714746
100* SA1_27219007_Chip-Seq_Bcells_Human0.93551851
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93490508
102* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92235626
103CTCF_26484167_Chip-Seq_Bcells_Mouse0.89927667
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89879020
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89601337
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88470670
107RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88397584
108* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88047913
109GATA1_22025678_ChIP-Seq_K562_Human0.87811537
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.87604750
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87311040
112GATA1_19941826_ChIP-Seq_K562_Human0.86513064
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85558749
114TAF2_19829295_ChIP-Seq_ESCs_Human0.85531379
115EGR1_19032775_ChIP-ChIP_M12_Human0.84887458
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83613456
117ETS1_20019798_ChIP-Seq_JURKAT_Human0.83012456
118E2F1_20622854_ChIP-Seq_HELA_Human0.82929287
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82533338
120CTCF_20526341_ChIP-Seq_ESCs_Human0.81573683
121FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81058372
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.79977999
123* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79500078
124XRN2_22483619_ChIP-Seq_HELA_Human0.79351070
125ELK3_25401928_ChIP-Seq_HUVEC_Human0.78997481
126DCP1A_22483619_ChIP-Seq_HELA_Human0.78860640
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78155042
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.77787077
129TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77314858
130ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76148521
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75594116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.47636031
2MP0001835_abnormal_antigen_presentation4.31946279
3MP0003763_abnormal_thymus_physiology3.98110132
4MP0009785_altered_susceptibility_to3.89053463
5MP0000685_abnormal_immune_system3.34351163
6MP0003436_decreased_susceptibility_to3.23823306
7* MP0005000_abnormal_immune_tolerance3.14317583
8* MP0005025_abnormal_response_to3.06454935
9MP0001800_abnormal_humoral_immune3.03672867
10MP0002148_abnormal_hypersensitivity_rea3.01002898
11* MP0002420_abnormal_adaptive_immunity2.90948650
12MP0005387_immune_system_phenotype2.89521188
13MP0001790_abnormal_immune_system2.89521188
14MP0003724_increased_susceptibility_to2.89255636
15* MP0001819_abnormal_immune_cell2.87922961
16* MP0002723_abnormal_immune_serum2.85451382
17* MP0002452_abnormal_antigen_presenting2.77554996
18MP0006082_CNS_inflammation2.70867544
19* MP0002419_abnormal_innate_immunity2.69955954
20MP0002166_altered_tumor_susceptibility2.65123181
21MP0002398_abnormal_bone_marrow2.56681734
22MP0009333_abnormal_splenocyte_physiolog2.54244758
23MP0002405_respiratory_system_inflammati2.47646772
24MP0002006_tumorigenesis2.41816762
25* MP0000716_abnormal_immune_system2.33524201
26MP0002396_abnormal_hematopoietic_system2.26824530
27MP0005464_abnormal_platelet_physiology2.16318713
28MP0010155_abnormal_intestine_physiology2.06928811
29* MP0000689_abnormal_spleen_morphology2.03511519
30* MP0002722_abnormal_immune_system2.02752764
31MP0001873_stomach_inflammation1.93428402
32* MP0002429_abnormal_blood_cell1.93297872
33MP0001845_abnormal_inflammatory_respons1.92690423
34MP0000703_abnormal_thymus_morphology1.87093882
35MP0001853_heart_inflammation1.79130730
36MP0003866_abnormal_defecation1.74441707
37MP0004947_skin_inflammation1.71034810
38MP0003303_peritoneal_inflammation1.69320063
39MP0005174_abnormal_tail_pigmentation1.61515369
40* MP0000858_altered_metastatic_potential1.61364629
41MP0002933_joint_inflammation1.60477345
42MP0001533_abnormal_skeleton_physiology1.54686570
43MP0005397_hematopoietic_system_phenotyp1.49872752
44MP0001545_abnormal_hematopoietic_system1.49872752
45MP0000465_gastrointestinal_hemorrhage1.49107185
46MP0008469_abnormal_protein_level1.47326812
47MP0002138_abnormal_hepatobiliary_system1.46358798
48MP0003806_abnormal_nucleotide_metabolis1.40425272
49MP0004808_abnormal_hematopoietic_stem1.39766438
50MP0000490_abnormal_crypts_of1.37102158
51* MP0003448_altered_tumor_morphology1.28447837
52MP0004510_myositis1.25663249
53MP0009764_decreased_sensitivity_to1.24267606
54MP0005075_abnormal_melanosome_morpholog1.23863274
55MP0005310_abnormal_salivary_gland1.19200450
56MP0005058_abnormal_lysosome_morphology1.16363927
57MP0000343_altered_response_to1.15316665
58MP0004381_abnormal_hair_follicle1.13569886
59MP0003300_gastrointestinal_ulcer1.09650955
60MP0009278_abnormal_bone_marrow1.08080224
61* MP0002019_abnormal_tumor_incidence1.07811579
62MP0002132_abnormal_respiratory_system1.06874721
63MP0001851_eye_inflammation0.98189220
64MP0008057_abnormal_DNA_replication0.97564787
65MP0000015_abnormal_ear_pigmentation0.97276309
66MP0000604_amyloidosis0.95640610
67MP0005166_decreased_susceptibility_to0.91435535
68MP0002095_abnormal_skin_pigmentation0.91064970
69MP0003690_abnormal_glial_cell0.89802163
70MP0003172_abnormal_lysosome_physiology0.88728123
71MP0008007_abnormal_cellular_replicative0.88327736
72MP0009379_abnormal_foot_pigmentation0.87961801
73MP0003191_abnormal_cellular_cholesterol0.87489433
74MP0002009_preneoplasia0.85892556
75* MP0002998_abnormal_bone_remodeling0.84420711
76* MP0009763_increased_sensitivity_to0.82545588
77MP0003693_abnormal_embryo_hatching0.81427573
78MP0003195_calcinosis0.78162963
79MP0008004_abnormal_stomach_pH0.77296417
80MP0006054_spinal_hemorrhage0.75050865
81MP0009840_abnormal_foam_cell0.72181523
82MP0001986_abnormal_taste_sensitivity0.71958633
83MP0003646_muscle_fatigue0.68903964
84MP0001663_abnormal_digestive_system0.65994833
85MP0000920_abnormal_myelination0.65937817
86MP0003077_abnormal_cell_cycle0.65773721
87MP0003075_altered_response_to0.61544378
88MP0008058_abnormal_DNA_repair0.59679341
89MP0000371_diluted_coat_color0.59664107
90MP0005390_skeleton_phenotype0.59458465
91MP0005165_increased_susceptibility_to0.59135179
92MP0005164_abnormal_response_to0.58740265
93MP0010094_abnormal_chromosome_stability0.57855857
94MP0003045_fibrosis0.57822834
95MP0005023_abnormal_wound_healing0.57176223
96MP0002837_dystrophic_cardiac_calcinosis0.54659718
97MP0000249_abnormal_blood_vessel0.54100840
98MP0009765_abnormal_xenobiotic_induced0.54014056
99MP0003186_abnormal_redox_activity0.53945018
100* MP0003795_abnormal_bone_structure0.53564512
101MP0004883_abnormal_blood_vessel0.53537639
102MP0000313_abnormal_cell_death0.53436167
103MP0004957_abnormal_blastocyst_morpholog0.53425593
104MP0001542_abnormal_bone_strength0.53059201
105MP0002136_abnormal_kidney_physiology0.51885569
106MP0005377_hearing/vestibular/ear_phenot0.50759888
107MP0003878_abnormal_ear_physiology0.50759888
108MP0008873_increased_physiological_sensi0.50591612
109MP0005381_digestive/alimentary_phenotyp0.50572586
110MP0003183_abnormal_peptide_metabolism0.49791551
111MP0005319_abnormal_enzyme/_coenzyme0.49573649
112MP0002139_abnormal_hepatobiliary_system0.47943159
113MP0005410_abnormal_fertilization0.47794121
114MP0001191_abnormal_skin_condition0.47655902
115MP0002693_abnormal_pancreas_physiology0.47185935
116MP0008874_decreased_physiological_sensi0.47123489
117MP0010352_gastrointestinal_tract_polyps0.45099016
118MP0000477_abnormal_intestine_morphology0.45007921
119MP0010307_abnormal_tumor_latency0.44452208
120MP0003828_pulmonary_edema0.40026742
121MP0005584_abnormal_enzyme/coenzyme_acti0.38895201
122MP0002277_abnormal_respiratory_mucosa0.38604574

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.89023075
2Recurrent abscess formation (HP:0002722)5.77508319
3Elevated erythrocyte sedimentation rate (HP:0003565)5.44235319
4Myositis (HP:0100614)5.06432548
5T lymphocytopenia (HP:0005403)4.96291048
6Abnormality of T cell number (HP:0011839)4.92836830
7Recurrent bacterial skin infections (HP:0005406)4.89996110
8Stomatitis (HP:0010280)4.65521682
9Abnormality of T cells (HP:0002843)4.23804658
10Recurrent fungal infections (HP:0002841)4.22313759
11IgM deficiency (HP:0002850)4.12339078
12Obstructive lung disease (HP:0006536)4.02530106
13Chronic obstructive pulmonary disease (HP:0006510)4.02530106
14Severe combined immunodeficiency (HP:0004430)3.99681502
15Recurrent bronchitis (HP:0002837)3.98698284
16Recurrent gram-negative bacterial infections (HP:0005420)3.92293779
17Mediastinal lymphadenopathy (HP:0100721)3.86856584
18Combined immunodeficiency (HP:0005387)3.85709837
19Chronic otitis media (HP:0000389)3.81470096
20Increased IgM level (HP:0003496)3.81211016
21IgG deficiency (HP:0004315)3.78296325
22Recurrent cutaneous fungal infections (HP:0011370)3.73943247
23Chronic mucocutaneous candidiasis (HP:0002728)3.73943247
24Recurrent skin infections (HP:0001581)3.72095104
25Optic neuritis (HP:0100653)3.67943659
26Retrobulbar optic neuritis (HP:0100654)3.67943659
27Abnormality of liposaccharide metabolism (HP:0010968)3.65570675
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.65570675
29Abnormality of glycolipid metabolism (HP:0010969)3.65570675
30Meningitis (HP:0001287)3.60895994
31Recurrent viral infections (HP:0004429)3.59796454
32Orchitis (HP:0100796)3.59742045
33Thrombocytosis (HP:0001894)3.55957217
34Abnormality of T cell physiology (HP:0011840)3.42761196
35Nasal polyposis (HP:0100582)3.39361644
36Abnormality of macrophages (HP:0004311)3.36382163
37Autoimmune thrombocytopenia (HP:0001973)3.22725543
38Panhypogammaglobulinemia (HP:0003139)3.20086494
39Vasculitis (HP:0002633)3.18668493
40Chronic sinusitis (HP:0011109)3.18659126
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.07048373
42Lymphopenia (HP:0001888)3.06090503
43Pustule (HP:0200039)3.04103932
44Autoimmune hemolytic anemia (HP:0001890)3.02042253
45Gingivitis (HP:0000230)3.01802191
46Abnormality of cells of the lymphoid lineage (HP:0012140)3.01637637
47Thyroiditis (HP:0100646)2.99578011
48Abnormality of eosinophils (HP:0001879)2.98931143
49Petechiae (HP:0000967)2.98072510
50Abnormality of the nasal mucosa (HP:0000433)2.97405000
51Hypergammaglobulinemia (HP:0010702)2.97085424
52Leukocytosis (HP:0001974)2.96067358
53Vacuolated lymphocytes (HP:0001922)2.90079659
54Encephalitis (HP:0002383)2.87690509
55Hemoptysis (HP:0002105)2.87322677
56Chronic diarrhea (HP:0002028)2.85770217
57Abnormality of the prostate (HP:0008775)2.81363052
58Pulmonary infiltrates (HP:0002113)2.71958171
59Keratoconjunctivitis sicca (HP:0001097)2.69254470
60Hypoplasia of the thymus (HP:0000778)2.69241837
61Spontaneous hematomas (HP:0007420)2.68111646
62Eosinophilia (HP:0001880)2.66739095
63Increased cerebral lipofuscin (HP:0011813)2.62713384
64Hypoproteinemia (HP:0003075)2.61328911
65Agammaglobulinemia (HP:0004432)2.58656547
66Joint swelling (HP:0001386)2.53662849
67Increased serum ferritin (HP:0003281)2.52954404
68Recurrent sinusitis (HP:0011108)2.50205296
69Lymphoma (HP:0002665)2.49584477
70Granulocytopenia (HP:0001913)2.49445035
71Epistaxis (HP:0000421)2.49125151
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.47730731
73Reticulocytopenia (HP:0001896)2.45790300
74Keratoconjunctivitis (HP:0001096)2.44093339
75Cellulitis (HP:0100658)2.41309626
76Prolonged bleeding time (HP:0003010)2.40371239
77Gastrointestinal infarctions (HP:0005244)2.39773899
78Abnormality of B cell number (HP:0010975)2.38560170
79B lymphocytopenia (HP:0010976)2.38560170
80Aplastic anemia (HP:0001915)2.34209187
81Systemic lupus erythematosus (HP:0002725)2.33512931
82Periodontitis (HP:0000704)2.30878494
83Urticaria (HP:0001025)2.27762640
84Arterial thrombosis (HP:0004420)2.23165431
85Reduced antithrombin III activity (HP:0001976)2.23117753
86Inflammation of the large intestine (HP:0002037)2.19797403
87Abnormality of iron homeostasis (HP:0011031)2.18032189
88Gastrointestinal inflammation (HP:0004386)2.17980950
89Bronchitis (HP:0012387)2.17279604
90IgA deficiency (HP:0002720)2.17056358
91Basal ganglia calcification (HP:0002135)2.16401105
92Hemiplegia (HP:0002301)2.13778479
93Abnormal number of erythroid precursors (HP:0012131)2.13583364
94Dysostosis multiplex (HP:0000943)2.11776402
95Abnormality of cells of the erythroid lineage (HP:0012130)2.10974048
96Recurrent pneumonia (HP:0006532)2.07902557
97Gangrene (HP:0100758)2.07831682
98Chest pain (HP:0100749)2.07527470
99Polyneuropathy (HP:0001271)2.06875145
100Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02914640
101Skin ulcer (HP:0200042)2.02190037
102Pulmonary embolism (HP:0002204)2.01668633
103Purpura (HP:0000979)2.01366645
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00762553
105Type I transferrin isoform profile (HP:0003642)1.99158789
106Gingival bleeding (HP:0000225)1.98610556
107Interstitial pulmonary disease (HP:0006530)1.98306414
108Increased IgE level (HP:0003212)1.98292461
109Poikiloderma (HP:0001029)1.93922258
110Abnormality of the pleura (HP:0002103)1.93411511
111Skin rash (HP:0000988)1.93030753
112Sepsis (HP:0100806)1.92754611
113Pulmonary fibrosis (HP:0002206)1.89488199
114Neutropenia (HP:0001875)1.89186662
115Hepatosplenomegaly (HP:0001433)1.88905771
116Arthralgia (HP:0002829)1.88875449
117Disinhibition (HP:0000734)1.87461672
118Anorexia (HP:0002039)1.86071435
119Glomerulopathy (HP:0100820)1.85996522
120Recurrent lower respiratory tract infections (HP:0002783)1.85611996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.39399292
2MAP4K14.86749711
3ZAP703.04358439
4BLK2.86180469
5IRAK42.84951055
6TEC2.62796738
7IKBKE2.62134275
8MAP3K142.54509675
9ITK2.52013341
10MAP3K122.50318857
11JAK32.41728251
12TYK22.40614467
13TBK12.25086243
14NME22.23652882
15BTK2.20959659
16KIT2.16274410
17BMPR22.14396921
18KDR1.84065642
19TESK21.82289304
20SYK1.75747516
21LCK1.74816327
22CSK1.68282326
23MAP3K111.63430264
24STK101.58636879
25JAK11.55188019
26NLK1.55081914
27GRK61.48794959
28CLK11.48396208
29FGFR41.43120726
30IKBKB1.42507624
31BCKDK1.34241744
32HCK1.33827327
33LYN1.30687543
34FLT31.29344979
35IRAK31.28560057
36RPS6KA41.24670373
37MST41.24316296
38RIPK41.23896701
39MOS1.15287073
40PIM21.13607348
41PIM11.09390869
42CSF1R1.09177191
43FES1.01370050
44FGR0.99963522
45MAP2K60.99727485
46FGFR30.95690772
47LRRK20.94939777
48TAOK30.91420745
49TNK20.89984164
50MYLK0.89685338
51ARAF0.89009792
52TAOK20.88046195
53NEK90.83882874
54TGFBR20.82402454
55MAP3K30.81303659
56MAP3K130.80332865
57ADRBK20.76499603
58ACVR1B0.74001702
59STK160.72119064
60TAOK10.71084361
61TLK10.70974112
62PDK10.70955605
63MAP2K30.69206624
64EIF2AK30.68758166
65SIK30.68225960
66CHUK0.66798046
67PRKCQ0.66352389
68JAK20.66268650
69ERN10.63018643
70LIMK10.58994391
71MARK30.58647267
72TESK10.54264066
73STK40.52195282
74TGFBR10.50046921
75EEF2K0.49594989
76CDK80.49563734
77MAPKAPK30.49389694
78TNIK0.49029500
79EIF2AK10.48021627
80DAPK10.47729529
81PRKCD0.47160411
82CDK40.44142204
83SCYL20.43972410
84ZAK0.43451548
85SRPK10.42387446
86PRKG20.40528779
87ILK0.40302162
88MAP3K10.38343487
89RPS6KA60.37691895
90PDPK10.37001845
91CAMKK10.36758480
92GRK70.36720668
93MUSK0.36709499
94INSR0.35673583
95EPHB10.35635865
96PAK40.35574354
97FYN0.35361047
98HIPK20.34615906
99MAP2K20.34120436
100ABL10.34113542
101IRAK10.34006637
102PIK3CA0.33612458
103CAMKK20.31354733
104VRK10.31311770
105EIF2AK20.31108656
106MAPK40.31017675
107TRPM70.30584118
108CDK90.30323791
109MAP3K50.30314167
110MAPK110.30132298
111PRKCH0.30032151
112MAP4K20.29756630
113PBK0.29449018
114GRK50.29367366
115SIK20.29251163
116BUB10.28775012
117PIK3CG0.27805302
118ATR0.27529499
119PASK0.27384566
120BRAF0.27211719
121IGF1R0.26459062
122MAPKAPK20.25108408
123RPS6KC10.24467242
124RPS6KL10.24467242
125VRK20.23851080
126MATK0.23544440
127ABL20.22452975
128PRPF4B0.22360508
129RIPK10.21819764
130PAK10.19434164
131PRKCA0.18385726
132ADRBK10.18316998
133DAPK30.18312794

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.23978498
2Graft-versus-host disease_Homo sapiens_hsa053323.90474117
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.00046203
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84447537
5Antigen processing and presentation_Homo sapiens_hsa046122.81160859
6Allograft rejection_Homo sapiens_hsa053302.68820938
7Leishmaniasis_Homo sapiens_hsa051402.59983618
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57337197
9Measles_Homo sapiens_hsa051622.51129142
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.45080328
11Ribosome_Homo sapiens_hsa030102.38174958
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.34557301
13T cell receptor signaling pathway_Homo sapiens_hsa046602.33922245
14Hematopoietic cell lineage_Homo sapiens_hsa046402.10842401
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98798671
16DNA replication_Homo sapiens_hsa030301.90122127
17Osteoclast differentiation_Homo sapiens_hsa043801.89733714
18Herpes simplex infection_Homo sapiens_hsa051681.69334369
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63055883
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61688275
21Asthma_Homo sapiens_hsa053101.60298723
22B cell receptor signaling pathway_Homo sapiens_hsa046621.60055444
23Legionellosis_Homo sapiens_hsa051341.57737214
24Autoimmune thyroid disease_Homo sapiens_hsa053201.54615341
25Staphylococcus aureus infection_Homo sapiens_hsa051501.53630761
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.49513395
27Viral myocarditis_Homo sapiens_hsa054161.40400923
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39820246
29Pertussis_Homo sapiens_hsa051331.37762683
30Malaria_Homo sapiens_hsa051441.35757561
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29094895
32Shigellosis_Homo sapiens_hsa051311.28650552
33Proteasome_Homo sapiens_hsa030501.27783522
34Type I diabetes mellitus_Homo sapiens_hsa049401.26048513
35Mismatch repair_Homo sapiens_hsa034301.25412997
36Tuberculosis_Homo sapiens_hsa051521.25251077
37Other glycan degradation_Homo sapiens_hsa005111.25002996
38Influenza A_Homo sapiens_hsa051641.22910011
39Chemokine signaling pathway_Homo sapiens_hsa040621.19222793
40Toxoplasmosis_Homo sapiens_hsa051451.16848872
41Salmonella infection_Homo sapiens_hsa051321.14073266
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.12486320
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08147287
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07966718
45Base excision repair_Homo sapiens_hsa034101.07522233
46Protein export_Homo sapiens_hsa030601.06446454
47Homologous recombination_Homo sapiens_hsa034401.04437339
48Hepatitis B_Homo sapiens_hsa051611.04199325
49Apoptosis_Homo sapiens_hsa042101.03385958
50TNF signaling pathway_Homo sapiens_hsa046680.99828602
51Rheumatoid arthritis_Homo sapiens_hsa053230.95030570
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88017298
53Acute myeloid leukemia_Homo sapiens_hsa052210.86519827
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83454863
55Pyrimidine metabolism_Homo sapiens_hsa002400.82847014
56RNA polymerase_Homo sapiens_hsa030200.82130567
57Nucleotide excision repair_Homo sapiens_hsa034200.80733122
58Epstein-Barr virus infection_Homo sapiens_hsa051690.78839413
59Platelet activation_Homo sapiens_hsa046110.78428467
60Lysosome_Homo sapiens_hsa041420.76151073
61Non-homologous end-joining_Homo sapiens_hsa034500.70845950
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70229669
63Spliceosome_Homo sapiens_hsa030400.69433766
64p53 signaling pathway_Homo sapiens_hsa041150.68385382
65Hepatitis C_Homo sapiens_hsa051600.65839687
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63136619
67Oxidative phosphorylation_Homo sapiens_hsa001900.61953699
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61537766
69HTLV-I infection_Homo sapiens_hsa051660.61397376
70Linoleic acid metabolism_Homo sapiens_hsa005910.60245715
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60190790
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57195176
73Pancreatic cancer_Homo sapiens_hsa052120.56833926
74Pentose phosphate pathway_Homo sapiens_hsa000300.55102858
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53794940
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53606559
77Collecting duct acid secretion_Homo sapiens_hsa049660.53057448
78Phagosome_Homo sapiens_hsa041450.52081140
79African trypanosomiasis_Homo sapiens_hsa051430.50777132
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50169892
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.48744443
82RNA degradation_Homo sapiens_hsa030180.48250092
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48145957
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47128796
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46536846
86Viral carcinogenesis_Homo sapiens_hsa052030.45427533
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45302335
88Arachidonic acid metabolism_Homo sapiens_hsa005900.41903331
89Caffeine metabolism_Homo sapiens_hsa002320.41664162
90N-Glycan biosynthesis_Homo sapiens_hsa005100.38366154
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37992875
92Fanconi anemia pathway_Homo sapiens_hsa034600.37112811
93Colorectal cancer_Homo sapiens_hsa052100.37027043
94Regulation of autophagy_Homo sapiens_hsa041400.36056277
95Phototransduction_Homo sapiens_hsa047440.35958786
96Ether lipid metabolism_Homo sapiens_hsa005650.35664486
97Parkinsons disease_Homo sapiens_hsa050120.34392747
98Basal transcription factors_Homo sapiens_hsa030220.34013327
99Chronic myeloid leukemia_Homo sapiens_hsa052200.33743898
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32963901
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.32589503
102VEGF signaling pathway_Homo sapiens_hsa043700.31942168
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.31817478
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30584745
105Prolactin signaling pathway_Homo sapiens_hsa049170.30274208
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.29185755
107Prion diseases_Homo sapiens_hsa050200.28972719
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27093728
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26914753
110Nitrogen metabolism_Homo sapiens_hsa009100.26375873
111Purine metabolism_Homo sapiens_hsa002300.24042274
112Systemic lupus erythematosus_Homo sapiens_hsa053220.23636295
113Cell cycle_Homo sapiens_hsa041100.22559085
114Endocytosis_Homo sapiens_hsa041440.22046760
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20859694
116Thyroid cancer_Homo sapiens_hsa052160.19579422
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18584059
118Complement and coagulation cascades_Homo sapiens_hsa046100.16264063
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.14986263
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.12389371
121Olfactory transduction_Homo sapiens_hsa047400.11264335
122Mineral absorption_Homo sapiens_hsa049780.09908007
123Alzheimers disease_Homo sapiens_hsa050100.09332459
124MAPK signaling pathway_Homo sapiens_hsa040100.06773135
125Amoebiasis_Homo sapiens_hsa051460.06140694
126Renin-angiotensin system_Homo sapiens_hsa046140.03297072

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