HDAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.54877098
2DNA replication initiation (GO:0006270)4.42796465
3DNA strand elongation (GO:0022616)4.35401798
4telomere maintenance via semi-conservative replication (GO:0032201)4.22920523
5DNA unwinding involved in DNA replication (GO:0006268)4.22536321
6mitotic chromosome condensation (GO:0007076)4.21499183
7maturation of SSU-rRNA (GO:0030490)4.20219888
8DNA replication checkpoint (GO:0000076)4.15074958
9formation of translation preinitiation complex (GO:0001731)4.12522736
10mitotic metaphase plate congression (GO:0007080)4.09516258
11Golgi transport vesicle coating (GO:0048200)4.05771958
12COPI coating of Golgi vesicle (GO:0048205)4.05771958
13nucleobase biosynthetic process (GO:0046112)4.01688683
14purine nucleobase biosynthetic process (GO:0009113)3.85347980
15telomere maintenance via recombination (GO:0000722)3.81459691
16ribosomal small subunit assembly (GO:0000028)3.81131665
17ribosomal small subunit biogenesis (GO:0042274)3.76301414
18ribosome assembly (GO:0042255)3.70891143
19protein localization to kinetochore (GO:0034501)3.70361409
20mitotic recombination (GO:0006312)3.62576483
21mitotic nuclear envelope disassembly (GO:0007077)3.62445006
22ribosomal large subunit biogenesis (GO:0042273)3.60241613
23ribonucleoprotein complex biogenesis (GO:0022613)3.58394027
24metaphase plate congression (GO:0051310)3.58185715
25CENP-A containing nucleosome assembly (GO:0034080)3.56700875
26viral transcription (GO:0019083)3.56700496
27ribosome biogenesis (GO:0042254)3.55921486
28telomere maintenance via telomere lengthening (GO:0010833)3.53866647
29translational termination (GO:0006415)3.53013193
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52674051
31DNA replication-dependent nucleosome assembly (GO:0006335)3.52227917
32DNA replication-dependent nucleosome organization (GO:0034723)3.52227917
33chromatin remodeling at centromere (GO:0031055)3.48977607
34kinetochore organization (GO:0051383)3.46210255
35nuclear pore organization (GO:0006999)3.44705025
36IMP biosynthetic process (GO:0006188)3.39431371
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37697830
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.35566836
39rRNA processing (GO:0006364)3.34308067
40pore complex assembly (GO:0046931)3.34127339
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31787185
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.31787185
43DNA replication-independent nucleosome assembly (GO:0006336)3.31586302
44DNA replication-independent nucleosome organization (GO:0034724)3.31586302
45DNA topological change (GO:0006265)3.31050809
46membrane disassembly (GO:0030397)3.30820583
47nuclear envelope disassembly (GO:0051081)3.30820583
48translational initiation (GO:0006413)3.30356398
49regulation of translational fidelity (GO:0006450)3.29301421
50regulation of spindle organization (GO:0090224)3.27641419
51DNA deamination (GO:0045006)3.27432006
52spliceosomal snRNP assembly (GO:0000387)3.25586761
53kinetochore assembly (GO:0051382)3.24742219
54rRNA metabolic process (GO:0016072)3.24624839
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23874087
56nuclear pore complex assembly (GO:0051292)3.23846687
57establishment of chromosome localization (GO:0051303)3.23778289
58spliceosomal tri-snRNP complex assembly (GO:0000244)3.23762757
59proline biosynthetic process (GO:0006561)3.20778178
60protein localization to chromosome, centromeric region (GO:0071459)3.20605756
61translational elongation (GO:0006414)3.15311698
62establishment of integrated proviral latency (GO:0075713)3.12461251
63transcription-coupled nucleotide-excision repair (GO:0006283)3.12407055
64rRNA modification (GO:0000154)3.11817916
65mitotic sister chromatid segregation (GO:0000070)3.11463519
66positive regulation of chromosome segregation (GO:0051984)3.06584274
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04715890
68attachment of spindle microtubules to kinetochore (GO:0008608)3.04134253
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04072707
70proteasome assembly (GO:0043248)3.03689787
71histone exchange (GO:0043486)3.03391991
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99614829
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99318299
74sister chromatid segregation (GO:0000819)2.98321185
75termination of RNA polymerase I transcription (GO:0006363)2.98296389
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97563604
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.97350267
78regulation of helicase activity (GO:0051095)2.97229018
79transcription elongation from RNA polymerase I promoter (GO:0006362)2.94759707
80mismatch repair (GO:0006298)2.94433937
81cotranslational protein targeting to membrane (GO:0006613)2.94294041
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92470442
83protein targeting to ER (GO:0045047)2.91210744
84negative regulation of chromosome segregation (GO:0051985)2.90395279
85spindle checkpoint (GO:0031577)2.89954155
86spliceosomal complex assembly (GO:0000245)2.89846292
87regulation of histone H3-K27 methylation (GO:0061085)2.89284849
88termination of RNA polymerase III transcription (GO:0006386)2.89101712
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.89101712
90negative regulation of erythrocyte differentiation (GO:0045647)2.88211074
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87515724
92negative regulation of sister chromatid segregation (GO:0033046)2.87515724
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.87515724
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87515724
95DNA duplex unwinding (GO:0032508)2.87222745
96viral mRNA export from host cell nucleus (GO:0046784)2.86754877
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86350829
98positive regulation of gamma-delta T cell activation (GO:0046645)2.86078936
99folic acid-containing compound biosynthetic process (GO:0009396)2.86025904
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86023682
101regulation of chromosome segregation (GO:0051983)2.85983379
102DNA geometric change (GO:0032392)2.85655355
103IMP metabolic process (GO:0046040)2.85614553
104regulation of double-strand break repair via homologous recombination (GO:0010569)2.85064295
1053-UTR-mediated mRNA stabilization (GO:0070935)2.84920345
106G1/S transition of mitotic cell cycle (GO:0000082)2.84625562
107cell cycle G1/S phase transition (GO:0044843)2.84625562
108cellular protein complex disassembly (GO:0043624)2.82534449
109telomere organization (GO:0032200)2.82443918
110mitotic spindle checkpoint (GO:0071174)2.82221234
111spindle assembly checkpoint (GO:0071173)2.82195234
112mitotic spindle assembly checkpoint (GO:0007094)2.81898573
113RNA splicing, via transesterification reactions (GO:0000375)2.80734881
114telomere maintenance (GO:0000723)2.80562854
115regulation of mitotic spindle organization (GO:0060236)2.78735973
116pseudouridine synthesis (GO:0001522)2.78518120
117chromosome condensation (GO:0030261)2.76739043
118antigen processing and presentation of endogenous antigen (GO:0019883)2.75053323
119negative regulation of mRNA processing (GO:0050686)2.71911241
120pentose-phosphate shunt (GO:0006098)2.70443510
121mRNA stabilization (GO:0048255)2.68662325
122RNA stabilization (GO:0043489)2.68662325
123negative regulation of RNA splicing (GO:0033119)2.68066230
124heterochromatin organization (GO:0070828)2.66883602
125regulation of RNA export from nucleus (GO:0046831)2.63853440
126thymic T cell selection (GO:0045061)2.63313411
127activation of Rac GTPase activity (GO:0032863)2.61841865
128negative regulation of mRNA metabolic process (GO:1903312)2.57342734
129DNA conformation change (GO:0071103)2.56587249
130viral life cycle (GO:0019058)2.55759652
131protein maturation by protein folding (GO:0022417)2.51074588
132positive thymic T cell selection (GO:0045059)2.50338018
133regulation of translational termination (GO:0006449)2.48780781
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46961462
135pinocytosis (GO:0006907)2.46725860
136nucleobase-containing small molecule interconversion (GO:0015949)2.44957358
137negative thymic T cell selection (GO:0045060)2.42035267
138trophectodermal cell differentiation (GO:0001829)2.41333540
139positive regulation of Cdc42 GTPase activity (GO:0043089)2.40970496
140dosage compensation (GO:0007549)2.40073997
141regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37708097
142protein export from nucleus (GO:0006611)2.36238061
143NIK/NF-kappaB signaling (GO:0038061)2.35180459
144establishment of protein localization to endoplasmic reticulum (GO:0072599)2.34931252
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34283706
146peptidyl-arginine omega-N-methylation (GO:0035247)2.34282096
147protein complex disassembly (GO:0043241)2.33615008
148regulation of nucleobase-containing compound transport (GO:0032239)2.33283698
149nuclear envelope organization (GO:0006998)2.32211192
150NADPH regeneration (GO:0006740)2.32073619
151DNA packaging (GO:0006323)2.31677885
152V(D)J recombination (GO:0033151)2.30527990
153B cell receptor signaling pathway (GO:0050853)2.30216759
154embryonic process involved in female pregnancy (GO:0060136)2.29741982
155negative T cell selection (GO:0043383)2.28958938
156cellular response to interleukin-4 (GO:0071353)2.27552602
157cellular hyperosmotic response (GO:0071474)2.26930010
158protein localization to endoplasmic reticulum (GO:0070972)2.26507195
159protein-DNA complex disassembly (GO:0032986)2.21663608
160nucleosome disassembly (GO:0006337)2.21663608
161establishment of viral latency (GO:0019043)2.20949594
162regulation of superoxide anion generation (GO:0032928)2.19732811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.81433450
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17492346
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.82279319
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64229708
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27193925
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19562459
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11695812
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10119234
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09502832
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.84961867
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79823171
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78699005
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.78059002
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76478865
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52971544
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41574036
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34832467
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30430537
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29618171
20XRN2_22483619_ChIP-Seq_HELA_Human2.28301976
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26988770
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24816611
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21405104
24VDR_23849224_ChIP-Seq_CD4+_Human2.21330047
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14146766
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09544131
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06080337
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01453198
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.98982656
30FOXP3_21729870_ChIP-Seq_TREG_Human1.96545952
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95164300
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94837623
33AR_21909140_ChIP-Seq_LNCAP_Human1.94321942
34DCP1A_22483619_ChIP-Seq_HELA_Human1.82788896
35TTF2_22483619_ChIP-Seq_HELA_Human1.82593499
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80713340
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.80127714
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79789448
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78330252
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78001242
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76562379
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74515807
43GABP_19822575_ChIP-Seq_HepG2_Human1.70433589
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69972902
45ELK1_19687146_ChIP-ChIP_HELA_Human1.68589219
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63457280
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.61883820
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.59366097
49MAF_26560356_Chip-Seq_TH1_Human1.58924456
50* EGR1_19374776_ChIP-ChIP_THP-1_Human1.58611583
51CIITA_25753668_ChIP-Seq_RAJI_Human1.57770300
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54923424
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53012633
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.51948519
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47620439
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47340384
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43522426
58ZNF263_19887448_ChIP-Seq_K562_Human1.43483331
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43266754
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43101378
61TCF7_22412390_ChIP-Seq_EML_Mouse1.42183700
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41575917
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41035163
64* UTX_26944678_Chip-Seq_JUKART_Human1.39461687
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39249407
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38662290
67MYC_22102868_ChIP-Seq_BL_Human1.35721356
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35492580
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35492580
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35492580
71KDM5A_27292631_Chip-Seq_BREAST_Human1.35070590
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34422745
73* RACK7_27058665_Chip-Seq_MCF-7_Human1.34192445
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33314350
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31571567
76LXR_22292898_ChIP-Seq_THP-1_Human1.30144145
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.29693054
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28817209
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28365113
80VDR_24763502_ChIP-Seq_THP-1_Human1.27663022
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.27574226
82NCOR1_26117541_ChIP-Seq_K562_Human1.24747225
83* MAF_26560356_Chip-Seq_TH2_Human1.24138527
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23604907
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23488268
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23093914
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22528521
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.22382660
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21884207
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21619017
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21063630
92* MYB_26560356_Chip-Seq_TH1_Human1.18577656
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18289773
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17172737
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16062204
96* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15188868
97MYB_26560356_Chip-Seq_TH2_Human1.14257291
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.14168564
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13865268
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13387219
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12959858
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12566009
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12137610
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12108244
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11278557
106* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10866892
107KDM2B_26808549_Chip-Seq_DND41_Human1.09611115
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08185637
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08093228
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07785000
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04457227
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03923720
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03681211
114* CHD1_26751641_Chip-Seq_LNCaP_Human1.03583869
115TFEB_21752829_ChIP-Seq_HELA_Human1.02681850
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02099403
117CLOCK_20551151_ChIP-Seq_293T_Human1.01594997
118* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01322484
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01193675
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00917789
121ATF3_27146783_Chip-Seq_COLON_Human1.00820855
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00363066
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99911177
124SPI1_23547873_ChIP-Seq_NB4_Human0.99878036
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96171986
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95362507
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93715935
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92857982
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.92743643
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.91185258
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90113396
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89567999
133MYC_18940864_ChIP-ChIP_HL60_Human0.87618089
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86281523
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86253689
136VDR_21846776_ChIP-Seq_THP-1_Human0.85045186
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84191220
138OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82908889
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82281309
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81506685
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.80632437
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77997494
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76279509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78950176
2MP0010094_abnormal_chromosome_stability4.50744389
3MP0008057_abnormal_DNA_replication4.42549214
4MP0003111_abnormal_nucleus_morphology4.17923602
5MP0004957_abnormal_blastocyst_morpholog3.98156987
6* MP0003077_abnormal_cell_cycle3.66737073
7MP0008058_abnormal_DNA_repair3.46429235
8MP0008007_abnormal_cellular_replicative2.73520885
9MP0010234_abnormal_vibrissa_follicle2.67503118
10MP0008932_abnormal_embryonic_tissue2.58591733
11MP0002877_abnormal_melanocyte_morpholog2.50325278
12MP0002396_abnormal_hematopoietic_system2.30851352
13MP0005451_abnormal_body_composition2.29868622
14MP0003705_abnormal_hypodermis_morpholog2.20560371
15MP0008877_abnormal_DNA_methylation2.13001753
16* MP0001730_embryonic_growth_arrest2.03303184
17* MP0000350_abnormal_cell_proliferation2.03287752
18MP0003123_paternal_imprinting2.02963785
19MP0003786_premature_aging1.99311187
20MP0002166_altered_tumor_susceptibility1.83130140
21MP0003436_decreased_susceptibility_to1.82638539
22MP0002009_preneoplasia1.74480485
23MP0004185_abnormal_adipocyte_glucose1.71790327
24MP0010352_gastrointestinal_tract_polyps1.70105270
25MP0004264_abnormal_extraembryonic_tissu1.68782095
26MP0003941_abnormal_skin_development1.59783823
27MP0003718_maternal_effect1.59074429
28MP0003763_abnormal_thymus_physiology1.57402929
29MP0000490_abnormal_crypts_of1.55738998
30MP0001873_stomach_inflammation1.54370834
31MP0009333_abnormal_splenocyte_physiolog1.54166655
32MP0008260_abnormal_autophagy1.53588433
33MP0006292_abnormal_olfactory_placode1.53283796
34MP0002796_impaired_skin_barrier1.51070653
35MP0001697_abnormal_embryo_size1.49284388
36MP0010307_abnormal_tumor_latency1.49039432
37* MP0001672_abnormal_embryogenesis/_devel1.48897426
38* MP0005380_embryogenesis_phenotype1.48897426
39MP0005058_abnormal_lysosome_morphology1.48276794
40MP0002006_tumorigenesis1.47594836
41MP0003566_abnormal_cell_adhesion1.47233273
42MP0003300_gastrointestinal_ulcer1.46786036
43MP0004947_skin_inflammation1.46387644
44MP0002085_abnormal_embryonic_tissue1.39983097
45MP0004808_abnormal_hematopoietic_stem1.37367568
46MP0003303_peritoneal_inflammation1.36361432
47* MP0002080_prenatal_lethality1.35420565
48MP0005000_abnormal_immune_tolerance1.34572170
49* MP0000313_abnormal_cell_death1.32572783
50MP0000703_abnormal_thymus_morphology1.32274770
51MP0010030_abnormal_orbit_morphology1.31223417
52MP0002019_abnormal_tumor_incidence1.30235382
53* MP0003984_embryonic_growth_retardation1.28477415
54MP0002084_abnormal_developmental_patter1.25193025
55MP0005464_abnormal_platelet_physiology1.24876612
56* MP0002088_abnormal_embryonic_growth/wei1.24621980
57MP0003315_abnormal_perineum_morphology1.23139319
58MP0002210_abnormal_sex_determination1.21851469
59MP0003453_abnormal_keratinocyte_physiol1.21195436
60* MP0002398_abnormal_bone_marrow1.20725846
61MP0005387_immune_system_phenotype1.19707271
62MP0001790_abnormal_immune_system1.19707271
63MP0003567_abnormal_fetal_cardiomyocyte1.19156023
64MP0005025_abnormal_response_to1.18770760
65MP0000678_abnormal_parathyroid_gland1.18273627
66MP0004197_abnormal_fetal_growth/weight/1.17179056
67MP0001293_anophthalmia1.17133015
68MP0002722_abnormal_immune_system1.17083224
69MP0003121_genomic_imprinting1.16367902
70MP0003191_abnormal_cellular_cholesterol1.15989227
71* MP0002086_abnormal_extraembryonic_tissu1.14655025
72MP0003866_abnormal_defecation1.13741470
73MP0001849_ear_inflammation1.10301837
74MP0000689_abnormal_spleen_morphology1.08606527
75MP0004133_heterotaxia1.07754229
76MP0001216_abnormal_epidermal_layer1.06324243
77MP0001145_abnormal_male_reproductive1.06224405
78MP0003136_yellow_coat_color1.05376556
79MP0005397_hematopoietic_system_phenotyp1.05065280
80MP0001545_abnormal_hematopoietic_system1.05065280
81MP0009278_abnormal_bone_marrow0.96672251
82MP0002419_abnormal_innate_immunity0.94971127
83MP0005671_abnormal_response_to0.94196718
84* MP0002429_abnormal_blood_cell0.94016546
85MP0001800_abnormal_humoral_immune0.93063639
86MP0004233_abnormal_muscle_weight0.92280294
87MP0001929_abnormal_gametogenesis0.90097851
88* MP0000716_abnormal_immune_system0.89544149
89MP0002938_white_spotting0.88727947
90MP0000858_altered_metastatic_potential0.87303277
91MP0000653_abnormal_sex_gland0.86400263
92MP0009785_altered_susceptibility_to0.84843840
93MP0004858_abnormal_nervous_system0.84645646
94MP0005666_abnormal_adipose_tissue0.84592756
95MP0002160_abnormal_reproductive_system0.83373833
96MP0001845_abnormal_inflammatory_respons0.83336568
97MP0003937_abnormal_limbs/digits/tail_de0.83147618
98MP0002148_abnormal_hypersensitivity_rea0.82648734
99MP0000537_abnormal_urethra_morphology0.82509572
100MP0001881_abnormal_mammary_gland0.82422619
101MP0009931_abnormal_skin_appearance0.82321030
102MP0002111_abnormal_tail_morphology0.80305818
103MP0005075_abnormal_melanosome_morpholog0.79946578
104MP0000685_abnormal_immune_system0.79387241
105MP0000465_gastrointestinal_hemorrhage0.79076955
106MP0001286_abnormal_eye_development0.78795016
107MP0005076_abnormal_cell_differentiation0.78731317
108MP0003890_abnormal_embryonic-extraembry0.78539180
109MP0002132_abnormal_respiratory_system0.78448299
110* MP0002420_abnormal_adaptive_immunity0.78422602
111MP0003806_abnormal_nucleotide_metabolis0.78172868
112MP0001835_abnormal_antigen_presentation0.78136861
113MP0004782_abnormal_surfactant_physiolog0.76776185
114* MP0001819_abnormal_immune_cell0.76765189
115MP0001727_abnormal_embryo_implantation0.76757630
116MP0003091_abnormal_cell_migration0.75980159
117* MP0002452_abnormal_antigen_presenting0.75657754
118MP0005023_abnormal_wound_healing0.75092945
119MP0002060_abnormal_skin_morphology0.74546621
120MP0002405_respiratory_system_inflammati0.74449625
121MP0009672_abnormal_birth_weight0.72804308
122MP0003119_abnormal_digestive_system0.72733000
123MP0002723_abnormal_immune_serum0.71332652
124MP0005389_reproductive_system_phenotype0.69681966
125MP0005384_cellular_phenotype0.69469169
126MP0005621_abnormal_cell_physiology0.68421265
127MP0001119_abnormal_female_reproductive0.67569389
128MP0003938_abnormal_ear_development0.66804659
129MP0002653_abnormal_ependyma_morphology0.66299703
130MP0003448_altered_tumor_morphology0.65755492
131MP0009379_abnormal_foot_pigmentation0.64587111
132MP0006054_spinal_hemorrhage0.63759015
133MP0002092_abnormal_eye_morphology0.63599348
134MP0000428_abnormal_craniofacial_morphol0.63457575
135MP0000049_abnormal_middle_ear0.62360211
136MP0002095_abnormal_skin_pigmentation0.62145455
137MP0000477_abnormal_intestine_morphology0.61332840
138MP0005501_abnormal_skin_physiology0.60520645
139MP0004381_abnormal_hair_follicle0.59612926
140MP0001853_heart_inflammation0.59106546
141MP0009053_abnormal_anal_canal0.58546889
142MP0010155_abnormal_intestine_physiology0.58387251
143MP0000358_abnormal_cell_content/0.58220903
144MP0002277_abnormal_respiratory_mucosa0.57806427

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.70416877
2Breast hypoplasia (HP:0003187)4.11719603
3Reticulocytopenia (HP:0001896)4.05269572
4Chromsome breakage (HP:0040012)3.71971209
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62727302
6Carpal bone hypoplasia (HP:0001498)3.23741757
7Abnormality of cells of the erythroid lineage (HP:0012130)3.18927760
8Patellar aplasia (HP:0006443)3.17236618
9Meckel diverticulum (HP:0002245)3.04183239
10Cerebral hypomyelination (HP:0006808)3.03932563
11Absent radius (HP:0003974)2.99285895
12Abnormal number of erythroid precursors (HP:0012131)2.98688702
13Aplasia/Hypoplasia of the patella (HP:0006498)2.97361552
14Abnormality of the preputium (HP:0100587)2.97148423
15Selective tooth agenesis (HP:0001592)2.94936550
16Rough bone trabeculation (HP:0100670)2.93985011
17Abnormality of the ileum (HP:0001549)2.92663518
18Recurrent viral infections (HP:0004429)2.92407560
19Abnormality of chromosome stability (HP:0003220)2.87755753
20Absent forearm bone (HP:0003953)2.83862348
21Aplasia involving forearm bones (HP:0009822)2.83862348
22Degeneration of anterior horn cells (HP:0002398)2.77768900
23Abnormality of the anterior horn cell (HP:0006802)2.77768900
24Medulloblastoma (HP:0002885)2.75876977
25Eczematoid dermatitis (HP:0000976)2.75796713
26Oral leukoplakia (HP:0002745)2.75751609
27Colon cancer (HP:0003003)2.75155300
28Colitis (HP:0002583)2.69505594
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.69422206
30Cellulitis (HP:0100658)2.69420590
31Ependymoma (HP:0002888)2.66231644
32Duplicated collecting system (HP:0000081)2.66177633
33Absent thumb (HP:0009777)2.60270193
34Agnosia (HP:0010524)2.59553359
35Agammaglobulinemia (HP:0004432)2.59053825
36Impulsivity (HP:0100710)2.55545788
37Seborrheic dermatitis (HP:0001051)2.54359808
38Aplastic anemia (HP:0001915)2.53465864
39Macrocytic anemia (HP:0001972)2.52041933
40Supernumerary spleens (HP:0009799)2.47980285
41Hyperacusis (HP:0010780)2.47550141
42Ectopic kidney (HP:0000086)2.45611971
43Ankyloglossia (HP:0010296)2.44810647
44Gastrointestinal stroma tumor (HP:0100723)2.43175858
45Duodenal stenosis (HP:0100867)2.42547978
46Small intestinal stenosis (HP:0012848)2.42547978
47Bone marrow hypocellularity (HP:0005528)2.42244617
48Progressive muscle weakness (HP:0003323)2.41965198
49Hypertensive crisis (HP:0100735)2.41694527
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41013423
51Myelodysplasia (HP:0002863)2.39451833
52Abnormality of the renal collecting system (HP:0004742)2.37916517
53Pallor (HP:0000980)2.36233044
54Gastrointestinal inflammation (HP:0004386)2.35756823
55Abnormal number of incisors (HP:0011064)2.35536826
56Premature graying of hair (HP:0002216)2.34807011
57Abnormality of oral frenula (HP:0000190)2.34667185
58Flat acetabular roof (HP:0003180)2.29752783
59Abnormality of the labia minora (HP:0012880)2.28830592
60Neoplasm of the pancreas (HP:0002894)2.28198504
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23998566
62Triphalangeal thumb (HP:0001199)2.23269355
63Abnormal trabecular bone morphology (HP:0100671)2.22424593
64Horseshoe kidney (HP:0000085)2.21968329
65Microvesicular hepatic steatosis (HP:0001414)2.21367722
66Abnormal lung lobation (HP:0002101)2.21200703
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19979786
68Abnormal gallbladder physiology (HP:0012438)2.19523935
69Cholecystitis (HP:0001082)2.19523935
70Lymphoma (HP:0002665)2.19450365
71Increased IgE level (HP:0003212)2.17299663
72Aplasia/Hypoplasia of the thymus (HP:0010515)2.17266127
73Asplenia (HP:0001746)2.17017356
74Tracheoesophageal fistula (HP:0002575)2.14521400
75Trismus (HP:0000211)2.14310612
76Viral hepatitis (HP:0006562)2.12772762
77Cleft eyelid (HP:0000625)2.12095297
78Abnormality of the fingertips (HP:0001211)2.11842470
79IgM deficiency (HP:0002850)2.10827914
80Sloping forehead (HP:0000340)2.10330016
81Autoimmune hemolytic anemia (HP:0001890)2.08775763
82Basal cell carcinoma (HP:0002671)2.08404639
83Ragged-red muscle fibers (HP:0003200)2.07795363
84Amaurosis fugax (HP:0100576)2.07213710
85Short thumb (HP:0009778)2.06887711
86Obstructive lung disease (HP:0006536)2.06338512
87Chronic obstructive pulmonary disease (HP:0006510)2.06338512
88Broad face (HP:0000283)2.06038497
89Abnormality of the duodenum (HP:0002246)2.05794684
90Atresia of the external auditory canal (HP:0000413)2.05652751
91Inflammation of the large intestine (HP:0002037)2.05356885
92Cellular immunodeficiency (HP:0005374)2.03909304
9311 pairs of ribs (HP:0000878)2.02926027
94Progressive external ophthalmoplegia (HP:0000590)2.02796015
95Vertebral compression fractures (HP:0002953)2.02502630
96Squamous cell carcinoma (HP:0002860)2.02395898
97Aplasia/Hypoplasia of the spleen (HP:0010451)2.01092864
98Panhypogammaglobulinemia (HP:0003139)2.00522690
99Abnormality of DNA repair (HP:0003254)2.00070143
100Abnormality of small intestinal villus morphology (HP:0011472)1.99916272
101Villous atrophy (HP:0011473)1.99916272
102Hypoplasia of the radius (HP:0002984)1.98905523
103Ureteral duplication (HP:0000073)1.98618295
104Meningitis (HP:0001287)1.95564175
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.95294949
106Proximal placement of thumb (HP:0009623)1.95215000
107Fatigue (HP:0012378)1.93262976
108Orthostatic hypotension (HP:0001278)1.93062963
109Abnormality of T cell physiology (HP:0011840)1.91951492
110IgG deficiency (HP:0004315)1.91180532
111Papilloma (HP:0012740)1.90957852
112Verrucae (HP:0200043)1.90957852
113Abnormality of the distal phalanges of the toes (HP:0010182)1.90533297
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.90096407
115Severe combined immunodeficiency (HP:0004430)1.89856145
116Irregular epiphyses (HP:0010582)1.88764765
117Combined immunodeficiency (HP:0005387)1.88529193
118Rhabdomyosarcoma (HP:0002859)1.87542592
119Recurrent abscess formation (HP:0002722)1.87295426
120Abnormality of the umbilical cord (HP:0010881)1.84095315
121Abnormality of reticulocytes (HP:0004312)1.83324972
122Deviation of the thumb (HP:0009603)1.83110415
123Lymphopenia (HP:0001888)1.82534125
124Microretrognathia (HP:0000308)1.81729470
125Absent epiphyses (HP:0010577)1.81579110
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81579110
127IgA deficiency (HP:0002720)1.81517403
128Abnormality of the fetal cardiovascular system (HP:0010948)1.80673025
129Abnormal umbilical cord blood vessels (HP:0011403)1.80673025
130Single umbilical artery (HP:0001195)1.80673025
131Septate vagina (HP:0001153)1.80483255
132Hemorrhage of the eye (HP:0011885)1.79625854
133Premature ovarian failure (HP:0008209)1.79616452
134Stenosis of the external auditory canal (HP:0000402)1.79494520
135Granulocytopenia (HP:0001913)1.79029703
136Thrombocytosis (HP:0001894)1.77158463
137Poikiloderma (HP:0001029)1.76690934
138Micronodular cirrhosis (HP:0001413)1.76178739
139Disproportionate tall stature (HP:0001519)1.75014822
140Recurrent bacterial skin infections (HP:0005406)1.74777746
141Osteomyelitis (HP:0002754)1.74400906
142Sparse lateral eyebrow (HP:0005338)1.73355399
143Abnormality of T cells (HP:0002843)1.73013079
144Entropion (HP:0000621)1.72949397
145Nephroblastoma (Wilms tumor) (HP:0002667)1.72931903
146Clubbing of toes (HP:0100760)1.72843193
147Pancytopenia (HP:0001876)1.72171544
148Recurrent fungal infections (HP:0002841)1.72067178
149Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71747447
150Osteolytic defects of the hand bones (HP:0009699)1.71352288
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.71352288
152Secondary amenorrhea (HP:0000869)1.70564660
153Abnormal foot bone ossification (HP:0010675)1.70243077
154Glossoptosis (HP:0000162)1.69411278
155Breast aplasia (HP:0100783)1.69106559
156Neoplasm of the oral cavity (HP:0100649)1.68990921
157Abnormality of the carotid arteries (HP:0005344)1.68557821
158Abnormality of abdominal situs (HP:0011620)1.68481194
159Abdominal situs inversus (HP:0003363)1.68481194
160Mediastinal lymphadenopathy (HP:0100721)1.67187411
161Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65852068
162Reticulocytosis (HP:0001923)1.65680904
163Long palpebral fissure (HP:0000637)1.65491617
164Insomnia (HP:0100785)1.64873761
165Abnormality of macrophages (HP:0004311)1.64679450
166Increased nuchal translucency (HP:0010880)1.64413632
167Asymmetry of the thorax (HP:0001555)1.64301865
168Abnormality of the thoracic spine (HP:0100711)1.64280341
169B lymphocytopenia (HP:0010976)1.63090974
170Progressive hearing impairment (HP:0001730)1.63077455
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.63008318
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.60698108
173Abnormality of the thymus (HP:0000777)1.59958104
174Metaphyseal cupping (HP:0003021)1.59567120
175Distal lower limb amyotrophy (HP:0008944)1.57774256
176Hepatitis (HP:0012115)1.57680939
177Patellar dislocation (HP:0002999)1.57297061
178Deep palmar crease (HP:0006191)1.54544702
179Skin ulcer (HP:0200042)1.53860030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87155857
2WEE14.22129939
3SMG13.58958208
4CDC73.51211580
5TRIB33.40517417
6EIF2AK12.99759285
7TSSK62.94515006
8ERN12.75241519
9PRPF4B2.69644130
10STK162.55025862
11SRPK12.45341890
12NEK22.36862021
13PLK42.36658395
14MKNK12.11472212
15TTK2.10674127
16SCYL22.02053685
17ICK1.93337104
18NME21.92930866
19TESK21.92601054
20PLK11.91221325
21BRSK21.91036302
22EIF2AK31.88221052
23RIPK41.85826378
24MKNK21.81608899
25PASK1.80228829
26VRK11.78853909
27CDK71.78787568
28MST1R1.69555075
29SIK11.64655916
30FGFR41.64421926
31PLK31.63173127
32ACVR1B1.62956961
33ATR1.56842477
34TLK11.56673905
35RPS6KB21.55952809
36AURKB1.53507350
37STK101.50150636
38MAP3K141.45135531
39VRK21.40794055
40MST41.39014689
41CDK121.38214677
42DYRK31.37690988
43EPHA21.36538511
44PNCK1.35303604
45TGFBR11.30576047
46NEK11.29904969
47MAP4K11.29572199
48MAP3K131.24876605
49CHEK21.23081685
50CHEK11.16640648
51STK41.15900458
52PBK1.13951715
53MAP3K81.12401404
54AURKA1.10313853
55RPS6KA41.07490605
56PKN21.06610138
57PAK41.05948659
58CDK41.03503754
59PIM21.01339430
60BRD41.01307966
61ZAK1.00985202
62PTK61.00656451
63KDR0.99628983
64KSR20.98614390
65BRSK10.97006898
66CLK10.95028240
67TXK0.94304521
68IRAK40.89326570
69MAPK110.87785915
70EIF2AK20.87241582
71RIPK10.83303624
72ATM0.83293437
73SIK30.83067091
74BLK0.82753499
75PIM10.81968047
76TESK10.80388535
77CDK20.76445787
78PRKCI0.74263405
79CCNB10.73991940
80TBK10.73788695
81GRK60.71534368
82IRAK30.71042124
83ALK0.70437356
84ARAF0.69770030
85* CSNK2A20.68393509
86EEF2K0.67677502
87CDK80.67205712
88* CSNK2A10.66556112
89PAK10.65749791
90ZAP700.65746368
91BTK0.61813277
92MELK0.61723105
93FLT30.61427987
94BMX0.60961288
95MAP2K20.60500505
96MTOR0.59528572
97CDK10.59345339
98MAP3K10.58202922
99STK30.58164234
100PDGFRA0.57876490
101RPS6KA50.57776232
102AKT30.56770489
103CSF1R0.56764051
104MAP3K30.55489003
105CDK90.54528368
106MAP3K100.50770373
107CSK0.50388259
108TAF10.47390541
109CDK60.46925940
110JAK30.44998657
111MET0.44686992
112LMTK20.43906710
113TEC0.43617168
114YES10.43296018
115LRRK20.43028545
116BMPR20.42817712
117RAF10.42571267
118FGFR30.42189115
119NLK0.41673277
120MAPKAPK20.40282584
121EPHB10.37904688
122NEK90.36810221
123LIMK10.36737954
124LYN0.36675429
125MAP2K30.35980083
126TYK20.35189820
127KIT0.35166722
128LCK0.35105885
129IKBKB0.34962755
130RET0.34852558
131NEK60.34685718
132JAK10.34618906
133HIPK20.34431328
134DYRK20.34124861
135CDC42BPA0.33033173
136PDPK10.32445946
137MAP3K20.32203840
138CSNK1G30.29990348
139BRAF0.28851387
140STK38L0.27168823
141BCR0.26546178
142* CSNK1E0.25867091
143PRKDC0.25555418
144STK240.24550644
145TAOK20.24129964
146PAK20.22929210

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59860129
2Mismatch repair_Homo sapiens_hsa034304.15359710
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54009762
4Ribosome_Homo sapiens_hsa030103.42340306
5RNA polymerase_Homo sapiens_hsa030203.41210401
6Proteasome_Homo sapiens_hsa030503.34286936
7Spliceosome_Homo sapiens_hsa030403.25477450
8Homologous recombination_Homo sapiens_hsa034403.11869888
9RNA transport_Homo sapiens_hsa030132.95452303
10Base excision repair_Homo sapiens_hsa034102.89661921
11Nucleotide excision repair_Homo sapiens_hsa034202.85530711
12* Cell cycle_Homo sapiens_hsa041102.57045083
13Non-homologous end-joining_Homo sapiens_hsa034502.43104471
14Pyrimidine metabolism_Homo sapiens_hsa002402.39200480
15Fanconi anemia pathway_Homo sapiens_hsa034602.37106366
16One carbon pool by folate_Homo sapiens_hsa006702.20545754
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14293308
18Basal transcription factors_Homo sapiens_hsa030222.12031270
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93302175
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85264833
21B cell receptor signaling pathway_Homo sapiens_hsa046621.83787734
22RNA degradation_Homo sapiens_hsa030181.81625862
23* Chronic myeloid leukemia_Homo sapiens_hsa052201.68366227
24p53 signaling pathway_Homo sapiens_hsa041151.65675191
25Non-small cell lung cancer_Homo sapiens_hsa052231.61730237
26mRNA surveillance pathway_Homo sapiens_hsa030151.60438143
27Pancreatic cancer_Homo sapiens_hsa052121.57982397
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48049890
29Primary immunodeficiency_Homo sapiens_hsa053401.40364545
30Bladder cancer_Homo sapiens_hsa052191.36727952
31Purine metabolism_Homo sapiens_hsa002301.32735318
32* Epstein-Barr virus infection_Homo sapiens_hsa051691.27501076
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.23379936
34Antigen processing and presentation_Homo sapiens_hsa046121.22895919
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11643082
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07942556
37Herpes simplex infection_Homo sapiens_hsa051681.03512163
38Carbon metabolism_Homo sapiens_hsa012001.03349221
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00711300
40Protein export_Homo sapiens_hsa030600.96963822
41Galactose metabolism_Homo sapiens_hsa000520.95945048
42Hepatitis C_Homo sapiens_hsa051600.93039601
43Vitamin B6 metabolism_Homo sapiens_hsa007500.91632685
44VEGF signaling pathway_Homo sapiens_hsa043700.87495442
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86940504
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86546564
47Endometrial cancer_Homo sapiens_hsa052130.85284992
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83909985
49* Viral carcinogenesis_Homo sapiens_hsa052030.83465464
50Toxoplasmosis_Homo sapiens_hsa051450.83411163
51Renal cell carcinoma_Homo sapiens_hsa052110.78679230
52Folate biosynthesis_Homo sapiens_hsa007900.75995413
53HTLV-I infection_Homo sapiens_hsa051660.75616245
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.74486471
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73908021
56Oocyte meiosis_Homo sapiens_hsa041140.72381181
57Measles_Homo sapiens_hsa051620.71782138
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70298320
59Osteoclast differentiation_Homo sapiens_hsa043800.67399656
60Systemic lupus erythematosus_Homo sapiens_hsa053220.66213810
61Pentose phosphate pathway_Homo sapiens_hsa000300.63869694
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63010474
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.61813145
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61087985
65Hematopoietic cell lineage_Homo sapiens_hsa046400.60995771
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59298578
67TNF signaling pathway_Homo sapiens_hsa046680.58304444
68Glutathione metabolism_Homo sapiens_hsa004800.57556054
69HIF-1 signaling pathway_Homo sapiens_hsa040660.56684400
70mTOR signaling pathway_Homo sapiens_hsa041500.56109648
71Legionellosis_Homo sapiens_hsa051340.56094318
72* MicroRNAs in cancer_Homo sapiens_hsa052060.54113791
73Allograft rejection_Homo sapiens_hsa053300.51811064
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.51306878
75Glioma_Homo sapiens_hsa052140.50785115
76Renin-angiotensin system_Homo sapiens_hsa046140.50303689
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.50121137
78Small cell lung cancer_Homo sapiens_hsa052220.49888434
79Prolactin signaling pathway_Homo sapiens_hsa049170.48817518
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47663812
81Tuberculosis_Homo sapiens_hsa051520.47529238
82Prion diseases_Homo sapiens_hsa050200.47383732
83* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45883333
84TGF-beta signaling pathway_Homo sapiens_hsa043500.45419617
85Autoimmune thyroid disease_Homo sapiens_hsa053200.45302517
86Basal cell carcinoma_Homo sapiens_hsa052170.45293702
87Salmonella infection_Homo sapiens_hsa051320.45243531
88Thyroid cancer_Homo sapiens_hsa052160.45078254
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45062473
90Apoptosis_Homo sapiens_hsa042100.44756046
91Asthma_Homo sapiens_hsa053100.44722702
92Shigellosis_Homo sapiens_hsa051310.43673811
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43006606
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.42853185
95Lysine degradation_Homo sapiens_hsa003100.42801083
96Biosynthesis of amino acids_Homo sapiens_hsa012300.42364800
97Insulin signaling pathway_Homo sapiens_hsa049100.41919257
98ErbB signaling pathway_Homo sapiens_hsa040120.41237213
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41037111
100* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40315371
101Hippo signaling pathway_Homo sapiens_hsa043900.39151413
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37709810
103Arachidonic acid metabolism_Homo sapiens_hsa005900.37261247
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36151110
105Huntingtons disease_Homo sapiens_hsa050160.34385285
106Hepatitis B_Homo sapiens_hsa051610.34160794
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.34150275
108Graft-versus-host disease_Homo sapiens_hsa053320.33617875
109Viral myocarditis_Homo sapiens_hsa054160.31740556
110Hedgehog signaling pathway_Homo sapiens_hsa043400.31087572
111T cell receptor signaling pathway_Homo sapiens_hsa046600.30717582
112Influenza A_Homo sapiens_hsa051640.29111745
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.27657491
114* Pathways in cancer_Homo sapiens_hsa052000.27454700
115Selenocompound metabolism_Homo sapiens_hsa004500.27373334
116Sulfur relay system_Homo sapiens_hsa041220.27262897
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26829313
118Colorectal cancer_Homo sapiens_hsa052100.26148920
119Regulation of autophagy_Homo sapiens_hsa041400.25504635
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25365002
121* Notch signaling pathway_Homo sapiens_hsa043300.25006747
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.24032957
123Leishmaniasis_Homo sapiens_hsa051400.23881107
124Other glycan degradation_Homo sapiens_hsa005110.22051360
125Prostate cancer_Homo sapiens_hsa052150.19589873
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19315712
127N-Glycan biosynthesis_Homo sapiens_hsa005100.17995640
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16618443
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16030601
130Metabolic pathways_Homo sapiens_hsa011000.15940945
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15902243
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15433260
133Adherens junction_Homo sapiens_hsa045200.15259586
134Acute myeloid leukemia_Homo sapiens_hsa052210.14405130
135Fructose and mannose metabolism_Homo sapiens_hsa000510.13934927
136Wnt signaling pathway_Homo sapiens_hsa043100.13712786

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