HDAC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.31287420
2positive regulation of gamma-delta T cell activation (GO:0046645)5.93945721
3antigen processing and presentation of endogenous antigen (GO:0019883)5.45126196
4DNA deamination (GO:0045006)5.28701298
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.23208912
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23208912
7mannose metabolic process (GO:0006013)5.05929839
8viral transcription (GO:0019083)5.00957939
9B cell receptor signaling pathway (GO:0050853)4.95874208
10positive regulation of B cell differentiation (GO:0045579)4.92011847
11regulation of gamma-delta T cell differentiation (GO:0045586)4.91971907
12negative regulation of erythrocyte differentiation (GO:0045647)4.77033704
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.74569200
14translational termination (GO:0006415)4.72832953
15regulation of gamma-delta T cell activation (GO:0046643)4.47313562
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.42074839
17cotranslational protein targeting to membrane (GO:0006613)4.28376031
18protein targeting to ER (GO:0045047)4.27605135
19regulation of B cell differentiation (GO:0045577)4.26624972
20translational elongation (GO:0006414)4.24508992
21protein localization to endoplasmic reticulum (GO:0070972)4.07651842
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06686297
23response to peptidoglycan (GO:0032494)4.04358952
24detection of bacterium (GO:0016045)4.00853246
25ribosomal small subunit biogenesis (GO:0042274)3.98996562
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.94706121
27modulation by symbiont of host immune response (GO:0052553)3.94706121
28positive regulation by symbiont of host defense response (GO:0052509)3.94706121
29modulation by symbiont of host defense response (GO:0052031)3.94706121
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94706121
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94706121
32valine metabolic process (GO:0006573)3.90901289
33detection of other organism (GO:0098543)3.90027877
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.88561471
35response to muramyl dipeptide (GO:0032495)3.82418518
36thymic T cell selection (GO:0045061)3.71037767
37viral life cycle (GO:0019058)3.68263982
38antigen processing and presentation via MHC class Ib (GO:0002475)3.66039527
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64112569
40regulation of B cell receptor signaling pathway (GO:0050855)3.63876899
41protoporphyrinogen IX biosynthetic process (GO:0006782)3.63432258
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60912601
43macrophage activation involved in immune response (GO:0002281)3.59311209
44cellular protein complex disassembly (GO:0043624)3.58784004
45T cell homeostasis (GO:0043029)3.54427239
46leukocyte aggregation (GO:0070486)3.53385466
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.49651600
48lymph node development (GO:0048535)3.47790539
49regulation of interferon-beta biosynthetic process (GO:0045357)3.42906534
50response to interleukin-15 (GO:0070672)3.39406786
51mature B cell differentiation involved in immune response (GO:0002313)3.36620344
52neutrophil activation involved in immune response (GO:0002283)3.32988835
53germinal center formation (GO:0002467)3.31195439
54cellular response to interferon-beta (GO:0035458)3.25032604
55T cell selection (GO:0045058)3.24430117
56regulation of mast cell degranulation (GO:0043304)3.21743163
57protein complex disassembly (GO:0043241)3.20840598
58detection of external biotic stimulus (GO:0098581)3.18792985
59regulation of ARF GTPase activity (GO:0032312)3.15869976
60protoporphyrinogen IX metabolic process (GO:0046501)3.10723895
61regulation of regulatory T cell differentiation (GO:0045589)3.09214455
62regulation of leukocyte degranulation (GO:0043300)3.08546420
63translational initiation (GO:0006413)3.08438810
64megakaryocyte development (GO:0035855)3.07851188
65mature B cell differentiation (GO:0002335)3.07693949
66purine-containing compound salvage (GO:0043101)3.07096442
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05818963
68negative T cell selection (GO:0043383)3.04930251
69leukocyte homeostasis (GO:0001776)3.03259046
70mucosal-associated lymphoid tissue development (GO:0048537)3.02277401
71Peyers patch development (GO:0048541)3.02277401
72response to interferon-beta (GO:0035456)3.01989043
73negative regulation of interleukin-12 production (GO:0032695)3.01679563
74positive regulation of granulocyte differentiation (GO:0030854)3.00956844
75macromolecular complex disassembly (GO:0032984)2.98657607
76lymphocyte homeostasis (GO:0002260)2.97248215
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93195864
78positive T cell selection (GO:0043368)2.90489764
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90096445
80negative regulation of phagocytosis (GO:0050765)2.89712544
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85309077
82negative regulation of cell killing (GO:0031342)2.85309077
83negative regulation of leukocyte mediated immunity (GO:0002704)2.83782404
84regulation of mast cell activation involved in immune response (GO:0033006)2.83314488
85negative regulation of humoral immune response (GO:0002921)2.82773976
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.82691644
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81901699
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81544332
89response to protozoan (GO:0001562)2.81267487
90regulation of T-helper 2 cell differentiation (GO:0045628)2.81188980
91mast cell activation (GO:0045576)2.80532648
92protein targeting to membrane (GO:0006612)2.80475111
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80366198
94detection of biotic stimulus (GO:0009595)2.79451318
95tolerance induction (GO:0002507)2.79207897
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79135926
97nuclear-transcribed mRNA catabolic process (GO:0000956)2.78320754
98regulation of T cell receptor signaling pathway (GO:0050856)2.77713509
99defense response to protozoan (GO:0042832)2.77129185
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76814304
101definitive hemopoiesis (GO:0060216)2.74920673
102cellular response to interleukin-4 (GO:0071353)2.74526456
103antigen receptor-mediated signaling pathway (GO:0050851)2.74511447
104positive thymic T cell selection (GO:0045059)2.73027039
105NIK/NF-kappaB signaling (GO:0038061)2.70391079
106interferon-gamma-mediated signaling pathway (GO:0060333)2.69491944
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.69339177
108modulation by virus of host process (GO:0019054)2.67311524
109cellular response to interleukin-15 (GO:0071350)2.66327156
110mRNA catabolic process (GO:0006402)2.65239251
111negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63775900
112regulation of erythrocyte differentiation (GO:0045646)2.63222081
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63026399
114platelet dense granule organization (GO:0060155)2.62279770
115maturation of SSU-rRNA (GO:0030490)2.61664859
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61443485
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61241391
118modulation by symbiont of host cellular process (GO:0044068)2.61054276
119activation of JUN kinase activity (GO:0007257)2.60095583
120lymphoid progenitor cell differentiation (GO:0002320)2.59411621
121necroptotic process (GO:0070266)2.58457843
122response to type I interferon (GO:0034340)2.58220720
123pentose-phosphate shunt (GO:0006098)2.57310898
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57209440
125T cell migration (GO:0072678)2.57112905
126negative regulation of innate immune response (GO:0045824)2.57103421
127signal complex assembly (GO:0007172)2.56982434
128regulation of granulocyte differentiation (GO:0030852)2.56938040
129purine nucleotide salvage (GO:0032261)2.56321775
130negative regulation of granulocyte differentiation (GO:0030853)2.55181003
131myeloid cell activation involved in immune response (GO:0002275)2.55145946
132detection of molecule of bacterial origin (GO:0032490)2.54287742
133regulation of regulated secretory pathway (GO:1903305)2.53759281
134cellular extravasation (GO:0045123)2.53201752
135negative regulation of cytokine production involved in immune response (GO:0002719)2.52601535
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.52142127
137response to host immune response (GO:0052572)2.52142127
138positive regulation of protein deacetylation (GO:0090312)2.51974251
139response to laminar fluid shear stress (GO:0034616)2.50970421
140regulation of antigen processing and presentation (GO:0002577)2.50559393
141positive regulation of Rap GTPase activity (GO:0032854)2.50049683
142negative regulation of interleukin-6 production (GO:0032715)2.49903915
143response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48690799
144response to host (GO:0075136)2.48690799
145response to host defenses (GO:0052200)2.48690799
146cellular hyperosmotic response (GO:0071474)2.48443595
147immunoglobulin mediated immune response (GO:0016064)2.48187762
148type I interferon signaling pathway (GO:0060337)2.47631063
149cellular response to type I interferon (GO:0071357)2.47631063
150embryonic hemopoiesis (GO:0035162)2.46686204
151B cell activation (GO:0042113)2.46607209
152cellular response to virus (GO:0098586)2.46201582
153respiratory burst (GO:0045730)2.45776672
154regulation of T cell tolerance induction (GO:0002664)2.45592303
155myeloid dendritic cell differentiation (GO:0043011)2.44879632
156negative regulation of T cell mediated immunity (GO:0002710)2.44688435
157positive regulation of DNA biosynthetic process (GO:2000573)2.44215227
158positive regulation of histone deacetylation (GO:0031065)2.43838886
159RNA catabolic process (GO:0006401)2.43631180
160tricarboxylic acid metabolic process (GO:0072350)2.43223001
161regulation of interleukin-2 biosynthetic process (GO:0045076)2.43197586
162CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42964862
163mast cell degranulation (GO:0043303)2.42206620
164mast cell activation involved in immune response (GO:0002279)2.42206620
165regulation of alpha-beta T cell proliferation (GO:0046640)2.40533305
166negative thymic T cell selection (GO:0045060)2.37993085
167heme biosynthetic process (GO:0006783)2.37338270
168negative regulation of B cell apoptotic process (GO:0002903)2.36977866
169B cell differentiation (GO:0030183)2.35095155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.70196129
2E2F7_22180533_ChIP-Seq_HELA_Human3.66910278
3MYC_22102868_ChIP-Seq_BL_Human3.39662009
4SCL_19346495_ChIP-Seq_HPC-7_Human3.10228947
5VDR_21846776_ChIP-Seq_THP-1_Human2.94233441
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.90785817
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88823559
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82472039
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82373314
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75493626
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72332330
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68578082
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64511143
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.54522553
15GATA1_22025678_ChIP-Seq_K562_Human2.42645155
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.35899323
17* KDM2B_26808549_Chip-Seq_DND41_Human2.33542662
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18068178
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06864417
20ERG_20887958_ChIP-Seq_HPC-7_Mouse1.98513064
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.97966880
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96872227
23SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.95603126
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95293119
25CIITA_25753668_ChIP-Seq_RAJI_Human1.95272832
26MAF_26560356_Chip-Seq_TH1_Human1.94714008
27RACK7_27058665_Chip-Seq_MCF-7_Human1.94705160
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.93948850
29VDR_24763502_ChIP-Seq_THP-1_Human1.92571106
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91572360
31P68_20966046_ChIP-Seq_HELA_Human1.89340827
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84189273
33UTX_26944678_Chip-Seq_JUKART_Human1.83037281
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82511886
35SPI1_23547873_ChIP-Seq_NB4_Human1.82198341
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81987342
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81018411
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80064000
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79496006
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79025498
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73193048
42MYB_26560356_Chip-Seq_TH1_Human1.72673595
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.71770988
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71402601
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.71381259
46MYB_26560356_Chip-Seq_TH2_Human1.71138165
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69175970
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68655977
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67487256
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.66224967
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65092688
52VDR_23849224_ChIP-Seq_CD4+_Human1.64288021
53FOXP3_21729870_ChIP-Seq_TREG_Human1.62075948
54* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60558326
55KDM2B_26808549_Chip-Seq_K562_Human1.60017918
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60003103
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.59745475
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58577550
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58356575
60* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58176971
61BCOR_27268052_Chip-Seq_Bcells_Human1.58070034
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.57139555
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57069394
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55058245
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.54220920
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53817879
67XRN2_22483619_ChIP-Seq_HELA_Human1.53513728
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.53381832
69* RUNX1_22412390_ChIP-Seq_EML_Mouse1.52727170
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52227209
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51986992
72MAF_26560356_Chip-Seq_TH2_Human1.49623953
73* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47824062
74SMC4_20622854_ChIP-Seq_HELA_Human1.47581452
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47219697
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45750848
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44960092
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.41857887
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41209820
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39422918
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.39038178
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38419907
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36010711
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.35561367
85NCOR1_26117541_ChIP-Seq_K562_Human1.33532659
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.33439249
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32008659
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.31940735
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.31380588
90* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30741581
91CREB1_26743006_Chip-Seq_LNCaP_Human1.29453351
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28497247
93RUNX_20019798_ChIP-Seq_JUKART_Human1.28343846
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27843677
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27738711
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27241170
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26708190
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26336167
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25991394
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25929250
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.25901312
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.25720622
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24907074
104GABP_19822575_ChIP-Seq_HepG2_Human1.24808836
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23778667
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23083385
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.22334093
108LXR_22292898_ChIP-Seq_THP-1_Human1.21562911
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21093599
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20956912
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.20871153
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20790050
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20233663
114BCL6_27268052_Chip-Seq_Bcells_Human1.19801757
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19608989
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.18992572
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18699830
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18519134
119PHF8_20622854_ChIP-Seq_HELA_Human1.18062185
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17704825
121SPI1_23127762_ChIP-Seq_K562_Human1.17695755
122E2F1_20622854_ChIP-Seq_HELA_Human1.16733938
123* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14554366
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14179165
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.13132789
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12505440
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11576940
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11542860
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11263275
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11048101
131MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11013579
132DCP1A_22483619_ChIP-Seq_HELA_Human1.09501622
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08991393
134RARB_24833708_ChIP-Seq_LIVER_Mouse1.08407784
135CTCF_27219007_Chip-Seq_Bcells_Human1.08166815
136* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07191307
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06939243
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05052503
139EGR1_19374776_ChIP-ChIP_THP-1_Human1.04480807
140RUNX1_27514584_Chip-Seq_MCF-7_Human1.02506676
141SA1_27219007_Chip-Seq_Bcells_Human1.02189109
142RXR_22158963_ChIP-Seq_LIVER_Mouse1.02068897
143GATA3_27048872_Chip-Seq_THYMUS_Human1.01675367
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01247270
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00355763
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00063964
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00019138
148MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99240879
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98683177
150* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98458325
151P300_27268052_Chip-Seq_Bcells_Human0.96121419
152* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95467227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.83292639
2MP0000685_abnormal_immune_system3.73052449
3MP0001835_abnormal_antigen_presentation3.68794632
4MP0003763_abnormal_thymus_physiology3.11228031
5MP0001800_abnormal_humoral_immune3.09564369
6MP0005387_immune_system_phenotype2.84570440
7MP0001790_abnormal_immune_system2.84570440
8MP0001873_stomach_inflammation2.79384967
9MP0005671_abnormal_response_to2.61496366
10MP0002452_abnormal_antigen_presenting2.42042849
11MP0002398_abnormal_bone_marrow2.41499682
12MP0009278_abnormal_bone_marrow2.34346248
13MP0000689_abnormal_spleen_morphology2.31285584
14MP0006054_spinal_hemorrhage2.30797201
15MP0002420_abnormal_adaptive_immunity2.27048668
16MP0002723_abnormal_immune_serum2.25500582
17MP0002166_altered_tumor_susceptibility2.22617559
18MP0001819_abnormal_immune_cell2.19420353
19MP0008260_abnormal_autophagy2.19056511
20MP0003705_abnormal_hypodermis_morpholog2.14832351
21MP0005075_abnormal_melanosome_morpholog2.08332966
22MP0005000_abnormal_immune_tolerance2.07154829
23MP0005365_abnormal_bile_salt2.05999718
24MP0000716_abnormal_immune_system2.05866893
25MP0009785_altered_susceptibility_to2.05079292
26MP0005025_abnormal_response_to2.01840794
27MP0002722_abnormal_immune_system2.01171518
28MP0005464_abnormal_platelet_physiology1.97242273
29MP0004808_abnormal_hematopoietic_stem1.93673702
30MP0006082_CNS_inflammation1.87327236
31MP0002429_abnormal_blood_cell1.86775956
32MP0000490_abnormal_crypts_of1.84177606
33MP0002419_abnormal_innate_immunity1.76578633
34MP0010155_abnormal_intestine_physiology1.73179820
35MP0003656_abnormal_erythrocyte_physiolo1.72959971
36MP0005220_abnormal_exocrine_pancreas1.68310985
37MP0000703_abnormal_thymus_morphology1.66116272
38MP0003436_decreased_susceptibility_to1.65465562
39MP0005076_abnormal_cell_differentiation1.58014677
40MP0003866_abnormal_defecation1.57843545
41MP0001853_heart_inflammation1.56574396
42MP0005174_abnormal_tail_pigmentation1.56003932
43MP0001849_ear_inflammation1.55372629
44MP0000858_altered_metastatic_potential1.55255482
45MP0001545_abnormal_hematopoietic_system1.54875414
46MP0005397_hematopoietic_system_phenotyp1.54875414
47MP0002138_abnormal_hepatobiliary_system1.51608237
48MP0002148_abnormal_hypersensitivity_rea1.50589736
49MP0001845_abnormal_inflammatory_respons1.49896403
50MP0002405_respiratory_system_inflammati1.48240851
51MP0004381_abnormal_hair_follicle1.46467377
52MP0002139_abnormal_hepatobiliary_system1.44552192
53MP0003693_abnormal_embryo_hatching1.43488767
54MP0005083_abnormal_biliary_tract1.42300688
55MP0000465_gastrointestinal_hemorrhage1.41457754
56MP0002998_abnormal_bone_remodeling1.35247692
57MP0009333_abnormal_splenocyte_physiolog1.34128422
58MP0001666_abnormal_nutrient_absorption1.27452275
59MP0003300_gastrointestinal_ulcer1.27303499
60MP0003453_abnormal_keratinocyte_physiol1.27015706
61MP0002933_joint_inflammation1.25279619
62MP0002006_tumorigenesis1.22532431
63MP0008469_abnormal_protein_level1.20927113
64MP0004185_abnormal_adipocyte_glucose1.20139733
65MP0003172_abnormal_lysosome_physiology1.19987002
66MP0002095_abnormal_skin_pigmentation1.17427990
67MP0005666_abnormal_adipose_tissue1.16456590
68MP0005409_darkened_coat_color1.16376911
69MP0003303_peritoneal_inflammation1.14601814
70MP0003091_abnormal_cell_migration1.11257131
71MP0001764_abnormal_homeostasis1.10952877
72MP0004947_skin_inflammation1.05340719
73MP0000609_abnormal_liver_physiology1.03950181
74MP0003183_abnormal_peptide_metabolism1.03676485
75MP0003191_abnormal_cellular_cholesterol1.03653468
76MP0005360_urolithiasis1.03397272
77MP0003868_abnormal_feces_composition1.02758940
78MP0005584_abnormal_enzyme/coenzyme_acti1.00921016
79MP0004858_abnormal_nervous_system1.00227819
80MP0003075_altered_response_to0.99512927
81MP0006036_abnormal_mitochondrial_physio0.99488570
82MP0008007_abnormal_cellular_replicative0.99419931
83MP0005375_adipose_tissue_phenotype0.99376303
84MP0003806_abnormal_nucleotide_metabolis0.99095123
85MP0003724_increased_susceptibility_to0.99079198
86MP0002019_abnormal_tumor_incidence0.98880711
87MP0002928_abnormal_bile_duct0.98054130
88MP0005058_abnormal_lysosome_morphology0.98008601
89MP0005390_skeleton_phenotype0.97929768
90MP0004147_increased_porphyrin_level0.95595044
91MP0001958_emphysema0.95508555
92MP0002132_abnormal_respiratory_system0.94503514
93MP0008961_abnormal_basal_metabolism0.94326235
94MP0009379_abnormal_foot_pigmentation0.93877042
95MP0001348_abnormal_lacrimal_gland0.93756292
96MP0004510_myositis0.91582922
97MP0003252_abnormal_bile_duct0.90576695
98MP0009840_abnormal_foam_cell0.90270885
99MP0000015_abnormal_ear_pigmentation0.90160353
100MP0000604_amyloidosis0.89914939
101MP0003828_pulmonary_edema0.89790189
102MP0001851_eye_inflammation0.89498480
103MP0003077_abnormal_cell_cycle0.89162018
104MP0003690_abnormal_glial_cell0.88957316
105MP0010094_abnormal_chromosome_stability0.88940950
106MP0008057_abnormal_DNA_replication0.88938188
107MP0002089_abnormal_postnatal_growth/wei0.87834622
108MP0001986_abnormal_taste_sensitivity0.87797906
109MP0005166_decreased_susceptibility_to0.87658929
110MP0009643_abnormal_urine_homeostasis0.87269867
111MP0001663_abnormal_digestive_system0.87036061
112MP0009764_decreased_sensitivity_to0.86466104
113MP0003279_aneurysm0.86081987
114MP0000678_abnormal_parathyroid_gland0.85457312
115MP0009697_abnormal_copulation0.84126793
116MP0000003_abnormal_adipose_tissue0.81932613
117MP0005310_abnormal_salivary_gland0.81414716
118MP0008874_decreased_physiological_sensi0.78137313
119MP0000598_abnormal_liver_morphology0.77713911
120MP0003448_altered_tumor_morphology0.77041877
121MP0009763_increased_sensitivity_to0.76660732
122MP0010368_abnormal_lymphatic_system0.76304698
123MP0000767_abnormal_smooth_muscle0.76210212
124MP0004130_abnormal_muscle_cell0.75431328
125MP0002254_reproductive_system_inflammat0.74658496
126MP0009384_cardiac_valve_regurgitation0.73931632
127MP0002970_abnormal_white_adipose0.73349169
128MP0001944_abnormal_pancreas_morphology0.73328209
129MP0005451_abnormal_body_composition0.73209209
130MP0010329_abnormal_lipoprotein_level0.73153346
131MP0005381_digestive/alimentary_phenotyp0.71554104
132MP0003795_abnormal_bone_structure0.71498839
133MP0003566_abnormal_cell_adhesion0.71277121
134MP0002136_abnormal_kidney_physiology0.71183762
135MP0001533_abnormal_skeleton_physiology0.70323502
136MP0003329_amyloid_beta_deposits0.70177212
137MP0005334_abnormal_fat_pad0.69243666
138MP0009931_abnormal_skin_appearance0.68769273
139MP0000249_abnormal_blood_vessel0.68270038
140MP0005085_abnormal_gallbladder_physiolo0.68189203

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.93463369
2Eczematoid dermatitis (HP:0000976)4.72765321
3IgM deficiency (HP:0002850)4.68436751
4Recurrent bronchitis (HP:0002837)4.49248627
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.23159634
6Chronic otitis media (HP:0000389)4.00815781
7Colitis (HP:0002583)3.89205052
8Inflammation of the large intestine (HP:0002037)3.88248814
9Thrombocytosis (HP:0001894)3.84862193
10Gastrointestinal inflammation (HP:0004386)3.82642029
11Panhypogammaglobulinemia (HP:0003139)3.78417786
12Broad face (HP:0000283)3.77897643
13Cellulitis (HP:0100658)3.74986966
14Gastrointestinal stroma tumor (HP:0100723)3.69644807
15Abnormality of cells of the erythroid lineage (HP:0012130)3.60400756
16Petechiae (HP:0000967)3.59396262
17Abnormality of macrophages (HP:0004311)3.58938627
18Abnormal number of erythroid precursors (HP:0012131)3.57712453
19Recurrent viral infections (HP:0004429)3.51212865
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.45445954
21Dysostosis multiplex (HP:0000943)3.42191776
22Thin bony cortex (HP:0002753)3.22478602
23Verrucae (HP:0200043)3.22400325
24Papilloma (HP:0012740)3.22400325
25Elevated erythrocyte sedimentation rate (HP:0003565)3.21941635
26Recurrent sinusitis (HP:0011108)3.21473016
27Lymphopenia (HP:0001888)3.20174226
28Increased IgE level (HP:0003212)3.12932848
29Aplastic anemia (HP:0001915)3.10593110
30Obstructive sleep apnea (HP:0002870)3.10251357
31Prolonged bleeding time (HP:0003010)3.05499544
32Obstructive lung disease (HP:0006536)3.04674950
33Chronic obstructive pulmonary disease (HP:0006510)3.04674950
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.99425514
35Cerebral palsy (HP:0100021)2.94313706
36Reticulocytopenia (HP:0001896)2.90705586
37Abnormality of polysaccharide metabolism (HP:0011012)2.89785118
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89785118
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89785118
40Gastrointestinal infarctions (HP:0005244)2.89311249
41Meningitis (HP:0001287)2.89026759
42Mucopolysacchariduria (HP:0008155)2.86224750
43Urinary glycosaminoglycan excretion (HP:0003541)2.86224750
44Mediastinal lymphadenopathy (HP:0100721)2.85126894
45J-shaped sella turcica (HP:0002680)2.84912415
46B lymphocytopenia (HP:0010976)2.84431894
47Abnormality of B cell number (HP:0010975)2.84431894
48Hemorrhage of the eye (HP:0011885)2.80970611
49Abnormality of the fingertips (HP:0001211)2.80039541
50Recurrent gram-negative bacterial infections (HP:0005420)2.78980147
51Abnormality of T cell physiology (HP:0011840)2.78703844
52Orchitis (HP:0100796)2.74305191
53Poikiloderma (HP:0001029)2.68611054
54Abnormality of T cells (HP:0002843)2.68422703
55Chronic sinusitis (HP:0011109)2.66410849
56Recurrent abscess formation (HP:0002722)2.65826744
57Gingivitis (HP:0000230)2.63964657
58Recurrent bacterial skin infections (HP:0005406)2.59326727
59Cervical subluxation (HP:0003308)2.58913968
60Fatigue (HP:0012378)2.56310253
61Joint stiffness (HP:0001387)2.54651500
62Neutropenia (HP:0001875)2.54614013
63Epistaxis (HP:0000421)2.54168262
64Abnormality of the nasal mucosa (HP:0000433)2.52847259
65Loss of speech (HP:0002371)2.45931472
66Recurrent fungal infections (HP:0002841)2.44839765
67Increased cerebral lipofuscin (HP:0011813)2.42083258
68Hypoplasia of the thymus (HP:0000778)2.42077919
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40489435
70Hyperacusis (HP:0010780)2.39444969
71Vacuolated lymphocytes (HP:0001922)2.37664746
72Cerebral aneurysm (HP:0004944)2.37645073
73Skin rash (HP:0000988)2.37536988
74Abnormality of liposaccharide metabolism (HP:0010968)2.35188435
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.35188435
76Abnormality of glycolipid metabolism (HP:0010969)2.35188435
77Optic neuritis (HP:0100653)2.34836578
78Retrobulbar optic neuritis (HP:0100654)2.34836578
79Pallor (HP:0000980)2.34368636
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33663500
81Increased serum ferritin (HP:0003281)2.32561114
82IgG deficiency (HP:0004315)2.31762280
83Malnutrition (HP:0004395)2.31349086
84Bronchitis (HP:0012387)2.31082413
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30552354
86Stridor (HP:0010307)2.30290624
87Recurrent skin infections (HP:0001581)2.29752659
88Nasal polyposis (HP:0100582)2.29276736
89Abnormal protein glycosylation (HP:0012346)2.29098292
90Abnormal glycosylation (HP:0012345)2.29098292
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29098292
92Abnormal protein N-linked glycosylation (HP:0012347)2.29098292
93Type I transferrin isoform profile (HP:0003642)2.28036678
94Severe visual impairment (HP:0001141)2.27838685
95Hypertensive crisis (HP:0100735)2.27047635
96Mitral stenosis (HP:0001718)2.25784550
97Impaired platelet aggregation (HP:0003540)2.22953928
98Abnormal platelet function (HP:0011869)2.22953928
99Emphysema (HP:0002097)2.22904277
100Osteomyelitis (HP:0002754)2.22023922
101Entropion (HP:0000621)2.22001843
102Systemic lupus erythematosus (HP:0002725)2.20993042
103Easy fatigability (HP:0003388)2.20936225
104Pancytopenia (HP:0001876)2.17854688
105Purpura (HP:0000979)2.16160443
106Interstitial pulmonary disease (HP:0006530)2.15654150
107Brushfield spots (HP:0001088)2.14895153
108Annular pancreas (HP:0001734)2.13967046
109Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13724328
110Reduced antithrombin III activity (HP:0001976)2.13459157
111Lymphoma (HP:0002665)2.11680884
112Myositis (HP:0100614)2.11668291
113T lymphocytopenia (HP:0005403)2.11560151
114Nuclear cataract (HP:0100018)2.10585819
115Stomatitis (HP:0010280)2.10486669
116Increased neuronal autofluorescent lipopigment (HP:0002074)2.10340490
117Chest pain (HP:0100749)2.09487319
118Neonatal hypoglycemia (HP:0001998)2.09442369
119Ragged-red muscle fibers (HP:0003200)2.09053132
120Spontaneous hematomas (HP:0007420)2.05719154
121Pulmonary infiltrates (HP:0002113)2.05587568
122Sepsis (HP:0100806)2.05037335
123Vasculitis (HP:0002633)2.04487571
124Distal lower limb amyotrophy (HP:0008944)2.04212357
125Hypertriglyceridemia (HP:0002155)2.03478984
126Encephalitis (HP:0002383)2.03475892
127Hypochromic anemia (HP:0001931)2.00892022
128Abnormality of the thoracic spine (HP:0100711)2.00663249
129Restrictive lung disease (HP:0002091)2.00652250
130Thoracic kyphosis (HP:0002942)2.00425578
131Metaphyseal cupping (HP:0003021)2.00297768
132Progressive muscle weakness (HP:0003323)1.99374530
133Abnormality of T cell number (HP:0011839)1.98771877
134Microretrognathia (HP:0000308)1.98461449
135Chronic mucocutaneous candidiasis (HP:0002728)1.98260641
136Recurrent cutaneous fungal infections (HP:0011370)1.98260641
137Polygenic inheritance (HP:0010982)1.96496157
138Gingival bleeding (HP:0000225)1.95860661
139Hemoptysis (HP:0002105)1.95590439
140Hepatosplenomegaly (HP:0001433)1.92386294
141Biconcave vertebral bodies (HP:0004586)1.91765043
142Hypoproteinemia (HP:0003075)1.91619830
143Broad metatarsal (HP:0001783)1.91318272
144Neuronal loss in central nervous system (HP:0002529)1.91010520
145Urticaria (HP:0001025)1.90903353
146Recurrent lower respiratory tract infections (HP:0002783)1.90895491
147Abnormality of DNA repair (HP:0003254)1.90421294
148Abnormality of iron homeostasis (HP:0011031)1.89370755
149Autoimmune thrombocytopenia (HP:0001973)1.88575430
150Chronic diarrhea (HP:0002028)1.85941255
151Pustule (HP:0200039)1.85927394
152Macrocytic anemia (HP:0001972)1.85814535
153Generalized aminoaciduria (HP:0002909)1.85203455
154Hepatitis (HP:0012115)1.84285794
155Flat occiput (HP:0005469)1.83179502
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82928740
157Premature loss of primary teeth (HP:0006323)1.81413476
158Asymmetric septal hypertrophy (HP:0001670)1.80868471
159Increased connective tissue (HP:0009025)1.79715143
160Hypergammaglobulinemia (HP:0010702)1.74203490
161Gastrointestinal dysmotility (HP:0002579)1.73640208
162Amyloidosis (HP:0011034)1.72797561
163Upper limb amyotrophy (HP:0009129)1.72309441
164Distal upper limb amyotrophy (HP:0007149)1.72309441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.80869985
2KIT3.61219291
3ERN13.15928120
4PRPF4B3.00404926
5PASK2.98955292
6RIPK42.85232458
7CSF1R2.72920155
8FLT32.50757748
9TYK22.38036799
10MAP3K102.35359295
11BCKDK2.28480489
12BTK2.27486156
13SIK22.21868072
14SMG12.21072328
15EEF2K2.04369029
16LRRK21.99903037
17GRK61.88061317
18JAK31.84992461
19ICK1.80605453
20SYK1.70102905
21NME21.68458433
22TRIB31.61293521
23ZAP701.57496126
24TGFBR21.54683131
25PKN21.54368084
26TEC1.51693815
27IRAK31.48495829
28CLK11.47978533
29TBK11.47804048
30IRAK41.45512945
31EPHB11.43371224
32TGFBR11.42133975
33BLK1.36707993
34STK161.35248653
35MAP2K31.35153076
36IKBKE1.26355712
37MAP3K31.25762855
38CDC42BPA1.24946473
39TAOK11.20752444
40PIM21.19874323
41MAP2K61.17874052
42FES1.16803735
43TESK21.16488697
44MAPKAPK31.15955502
45KDR1.15311371
46SIK11.11441498
47STK101.10664769
48MAP3K61.10214381
49TAOK31.10013723
50WEE11.08519624
51LYN1.08237105
52TAOK21.05887779
53LCK1.04809337
54MAP3K71.00932847
55MAP3K11.00823120
56ITK0.97769117
57DYRK30.97074365
58JAK10.97029881
59DYRK1B0.95205890
60PIM10.95133800
61PDPK10.94192767
62MAP3K140.89097979
63RPS6KA20.88509271
64MAPK110.88317074
65CDK120.87133123
66CDK190.83948339
67HCK0.83223133
68MAPK120.81711652
69MAPK150.80149910
70TLK10.79222969
71PDK10.79175612
72ADRBK20.78901646
73TNIK0.77974731
74FGFR40.77472177
75IKBKB0.77009056
76TNK20.76968663
77RPS6KB20.76288811
78TXK0.75253984
79CDK40.74638604
80SIK30.74283171
81BMX0.74015414
82PTK60.72951408
83MATK0.72281632
84MAPK40.71674521
85FGR0.71096497
86PIK3CG0.70565607
87IRAK20.70436287
88NEK20.67598996
89HIPK20.65519034
90DAPK10.65004282
91KSR20.64590936
92MUSK0.63649527
93SCYL20.63561848
94BRSK20.61588554
95MAP2K20.61261393
96PRKD20.58540528
97MARK30.58479260
98VRK10.58161000
99TTN0.57848351
100MARK20.56056035
101PDGFRA0.56020472
102TESK10.55018362
103PRKD30.54753886
104PRKCH0.53844774
105RET0.53409373
106MAPKAPK50.53251978
107FGFR30.52907279
108ATR0.52131529
109CHUK0.52048674
110MTOR0.51371128
111DDR20.47651639
112CSK0.47172743
113MST1R0.46989320
114ILK0.46854319
115EPHA20.45986835
116RPS6KA60.45959135
117CAMKK10.44278776
118PAK20.43861090
119TYRO30.42440959
120TIE10.41568423
121MAP3K130.41417732
122FYN0.39222179
123JAK20.38411524
124PRKD10.37394846
125MAP3K110.36987704
126MAPKAPK20.36383093
127NLK0.35900185
128PTK2B0.35890759
129PAK40.34498812
130MAPK70.34280841
131RIPK10.34229302
132BRD40.33910514
133CCNB10.32983787
134RPS6KL10.30414280
135RPS6KC10.30414280
136PRKCQ0.28525232
137MAPK30.27825331
138TSSK60.26464660

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.35466679
2Ribosome_Homo sapiens_hsa030103.89413499
3B cell receptor signaling pathway_Homo sapiens_hsa046623.03171687
4DNA replication_Homo sapiens_hsa030302.67156303
5Base excision repair_Homo sapiens_hsa034102.22606170
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20281240
7Caffeine metabolism_Homo sapiens_hsa002322.15453530
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.15203590
9Hematopoietic cell lineage_Homo sapiens_hsa046402.12274422
10Non-homologous end-joining_Homo sapiens_hsa034502.07755132
11Folate biosynthesis_Homo sapiens_hsa007902.03811315
12Allograft rejection_Homo sapiens_hsa053301.92365660
13Graft-versus-host disease_Homo sapiens_hsa053321.76729620
14Protein export_Homo sapiens_hsa030601.74452244
15Autoimmune thyroid disease_Homo sapiens_hsa053201.72908450
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.66461916
17Mismatch repair_Homo sapiens_hsa034301.65685364
18VEGF signaling pathway_Homo sapiens_hsa043701.60321372
19Antigen processing and presentation_Homo sapiens_hsa046121.59586048
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.57946758
21N-Glycan biosynthesis_Homo sapiens_hsa005101.57746805
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.54381863
23Pyrimidine metabolism_Homo sapiens_hsa002401.48925337
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48892931
25Spliceosome_Homo sapiens_hsa030401.42654461
26Other glycan degradation_Homo sapiens_hsa005111.40855109
27Leishmaniasis_Homo sapiens_hsa051401.39889572
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37829846
29TNF signaling pathway_Homo sapiens_hsa046681.32637320
30Measles_Homo sapiens_hsa051621.32502617
31Propanoate metabolism_Homo sapiens_hsa006401.31803023
32Chronic myeloid leukemia_Homo sapiens_hsa052201.30390626
33Herpes simplex infection_Homo sapiens_hsa051681.29455238
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.28122300
35Lysosome_Homo sapiens_hsa041421.26623344
36Non-small cell lung cancer_Homo sapiens_hsa052231.26534932
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26483909
38Asthma_Homo sapiens_hsa053101.25140353
39Selenocompound metabolism_Homo sapiens_hsa004501.24233061
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23076640
41Type I diabetes mellitus_Homo sapiens_hsa049401.22938678
42Pentose phosphate pathway_Homo sapiens_hsa000301.22196036
43Viral myocarditis_Homo sapiens_hsa054161.22187430
44ABC transporters_Homo sapiens_hsa020101.20699812
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18750518
46Fatty acid degradation_Homo sapiens_hsa000711.17612418
47Hepatitis C_Homo sapiens_hsa051601.15683550
48Homologous recombination_Homo sapiens_hsa034401.15652069
49Osteoclast differentiation_Homo sapiens_hsa043801.14616447
50Malaria_Homo sapiens_hsa051441.13623917
51Chemokine signaling pathway_Homo sapiens_hsa040621.13181745
52Sulfur relay system_Homo sapiens_hsa041221.12144394
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.11095194
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10115552
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03875013
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03473801
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.03460294
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03413286
59Fructose and mannose metabolism_Homo sapiens_hsa000511.01272286
60Phospholipase D signaling pathway_Homo sapiens_hsa040721.00696887
61GnRH signaling pathway_Homo sapiens_hsa049120.98513603
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98232305
63Platelet activation_Homo sapiens_hsa046110.97383092
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96683753
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95009952
66Acute myeloid leukemia_Homo sapiens_hsa052210.94869979
67mTOR signaling pathway_Homo sapiens_hsa041500.94391318
68Pancreatic cancer_Homo sapiens_hsa052120.93741522
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93086412
70Prolactin signaling pathway_Homo sapiens_hsa049170.91956634
71Tryptophan metabolism_Homo sapiens_hsa003800.91592651
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91472556
73Lysine degradation_Homo sapiens_hsa003100.89896614
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.88492014
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.88139982
76Salmonella infection_Homo sapiens_hsa051320.87436356
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.86985571
78Choline metabolism in cancer_Homo sapiens_hsa052310.85827775
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84985633
80Peroxisome_Homo sapiens_hsa041460.83988790
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83014104
82Bladder cancer_Homo sapiens_hsa052190.81297352
83Nucleotide excision repair_Homo sapiens_hsa034200.80536229
84T cell receptor signaling pathway_Homo sapiens_hsa046600.79474496
85Influenza A_Homo sapiens_hsa051640.79259556
86Endocytosis_Homo sapiens_hsa041440.79134236
87Staphylococcus aureus infection_Homo sapiens_hsa051500.78988322
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78959913
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.77691299
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77315381
91Shigellosis_Homo sapiens_hsa051310.76241351
92Insulin resistance_Homo sapiens_hsa049310.76079314
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75531903
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.75496538
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75224336
96Epstein-Barr virus infection_Homo sapiens_hsa051690.74950283
97Legionellosis_Homo sapiens_hsa051340.74502612
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74169466
99One carbon pool by folate_Homo sapiens_hsa006700.73401942
100Phagosome_Homo sapiens_hsa041450.72607692
101African trypanosomiasis_Homo sapiens_hsa051430.72422622
102Inositol phosphate metabolism_Homo sapiens_hsa005620.72367688
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72111175
104Pertussis_Homo sapiens_hsa051330.71678786
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69431983
106Rheumatoid arthritis_Homo sapiens_hsa053230.69204699
107Endometrial cancer_Homo sapiens_hsa052130.69173397
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68537923
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67988617
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67707544
111beta-Alanine metabolism_Homo sapiens_hsa004100.66803595
112Insulin signaling pathway_Homo sapiens_hsa049100.65617455
113Purine metabolism_Homo sapiens_hsa002300.64482469
114Amoebiasis_Homo sapiens_hsa051460.64321464
115Pancreatic secretion_Homo sapiens_hsa049720.62939720
116Renal cell carcinoma_Homo sapiens_hsa052110.62717767
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61757730
118Apoptosis_Homo sapiens_hsa042100.61676892
119ErbB signaling pathway_Homo sapiens_hsa040120.60908638
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59820551
121Complement and coagulation cascades_Homo sapiens_hsa046100.59400334
122p53 signaling pathway_Homo sapiens_hsa041150.59053139
123Pyruvate metabolism_Homo sapiens_hsa006200.58523584
124Glioma_Homo sapiens_hsa052140.58229048
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58038879
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57946029
127Prion diseases_Homo sapiens_hsa050200.57812618
128MAPK signaling pathway_Homo sapiens_hsa040100.57592451
129Biosynthesis of amino acids_Homo sapiens_hsa012300.56099810
130RNA polymerase_Homo sapiens_hsa030200.55833896
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55667596
132RNA degradation_Homo sapiens_hsa030180.55597458
133Estrogen signaling pathway_Homo sapiens_hsa049150.54452758
134Carbon metabolism_Homo sapiens_hsa012000.54251324
135Toxoplasmosis_Homo sapiens_hsa051450.53768638
136Systemic lupus erythematosus_Homo sapiens_hsa053220.53488745
137* Viral carcinogenesis_Homo sapiens_hsa052030.53308466
138Hepatitis B_Homo sapiens_hsa051610.52807318
139Notch signaling pathway_Homo sapiens_hsa043300.52784144
140Tuberculosis_Homo sapiens_hsa051520.52013152
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51885189
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51045496
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50000584
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.49912223
145Fatty acid elongation_Homo sapiens_hsa000620.49908753
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48992868
147Fatty acid metabolism_Homo sapiens_hsa012120.48185152
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47806360
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47386732
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47140274
151FoxO signaling pathway_Homo sapiens_hsa040680.45681511
152Colorectal cancer_Homo sapiens_hsa052100.45235326
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44873776
154HTLV-I infection_Homo sapiens_hsa051660.44771114
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44386847
156Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43742745
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.42799445
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.40977840

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