HDAC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30377232
2synaptic vesicle maturation (GO:0016188)5.21291249
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84003247
4locomotory exploration behavior (GO:0035641)4.61044438
5synaptic vesicle exocytosis (GO:0016079)4.56566019
6positive regulation of synapse maturation (GO:0090129)4.53678043
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47794923
8glutamate secretion (GO:0014047)4.47574295
9vocalization behavior (GO:0071625)4.44818140
10regulation of synaptic vesicle exocytosis (GO:2000300)4.36156929
11gamma-aminobutyric acid transport (GO:0015812)4.32570017
12neurotransmitter secretion (GO:0007269)4.22020168
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07212930
14sperm capacitation (GO:0048240)4.07111246
15neuronal action potential propagation (GO:0019227)4.00742475
16regulation of synaptic vesicle transport (GO:1902803)3.91199029
17regulation of glutamate receptor signaling pathway (GO:1900449)3.90685467
18regulation of neuronal synaptic plasticity (GO:0048168)3.87474399
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.83387804
20cerebellar granule cell differentiation (GO:0021707)3.81629718
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.80077879
22neuron cell-cell adhesion (GO:0007158)3.77633837
23negative regulation of inclusion body assembly (GO:0090084)3.72343223
24protein localization to synapse (GO:0035418)3.70073000
25neuromuscular process controlling posture (GO:0050884)3.69759235
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69748640
27neurotransmitter transport (GO:0006836)3.58644543
28exploration behavior (GO:0035640)3.53991343
29regulation of synapse maturation (GO:0090128)3.52136320
30glycine transport (GO:0015816)3.49887355
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.46674568
32cellular potassium ion homeostasis (GO:0030007)3.45749275
33neurotransmitter-gated ion channel clustering (GO:0072578)3.43119739
34dendritic spine morphogenesis (GO:0060997)3.41770450
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40155629
36regulation of synapse structural plasticity (GO:0051823)3.40027920
37regulation of neurotransmitter levels (GO:0001505)3.38236877
38layer formation in cerebral cortex (GO:0021819)3.37801608
39synaptic transmission, glutamatergic (GO:0035249)3.35990429
40neuron-neuron synaptic transmission (GO:0007270)3.32084116
41glutamate receptor signaling pathway (GO:0007215)3.31183455
42positive regulation of dendritic spine development (GO:0060999)3.28811634
43acrosome reaction (GO:0007340)3.28686952
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25921328
45sperm motility (GO:0030317)3.22783333
46sodium ion export (GO:0071436)3.22657266
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21356366
48long-term memory (GO:0007616)3.20074164
49dendritic spine organization (GO:0097061)3.19649274
50activation of protein kinase A activity (GO:0034199)3.18364955
51amino acid import (GO:0043090)3.17464833
52regulation of inclusion body assembly (GO:0090083)3.17317562
53transmission of nerve impulse (GO:0019226)3.17030884
54postsynaptic membrane organization (GO:0001941)3.15541432
55proline transport (GO:0015824)3.14975566
56regulation of ARF protein signal transduction (GO:0032012)3.14807285
57central nervous system myelination (GO:0022010)3.14558025
58axon ensheathment in central nervous system (GO:0032291)3.14558025
59mating behavior (GO:0007617)3.10629911
60prepulse inhibition (GO:0060134)3.10152333
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09493182
62neuron recognition (GO:0008038)3.05330315
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04455605
64cellular sodium ion homeostasis (GO:0006883)3.01483266
65positive regulation of membrane potential (GO:0045838)3.01058486
66behavioral response to cocaine (GO:0048148)2.98072269
67neuromuscular process controlling balance (GO:0050885)2.97849151
68neuronal ion channel clustering (GO:0045161)2.94524075
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93928292
70regulation of postsynaptic membrane potential (GO:0060078)2.93250812
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90635732
72regulation of synaptic plasticity (GO:0048167)2.90449593
73gamma-aminobutyric acid signaling pathway (GO:0007214)2.89514435
74regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.88553846
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86811812
76cerebellar Purkinje cell differentiation (GO:0021702)2.85845749
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85426500
78L-amino acid import (GO:0043092)2.85270105
79neuromuscular synaptic transmission (GO:0007274)2.84546699
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83795876
81adult walking behavior (GO:0007628)2.83498111
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83321711
83regulation of neurotransmitter secretion (GO:0046928)2.83272007
84membrane hyperpolarization (GO:0060081)2.81665340
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80318072
86auditory behavior (GO:0031223)2.78915065
87cerebellar Purkinje cell layer development (GO:0021680)2.78449822
88acidic amino acid transport (GO:0015800)2.78311643
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.78188316
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77390211
91response to auditory stimulus (GO:0010996)2.77016338
92long-term synaptic potentiation (GO:0060291)2.75469529
93synaptic vesicle endocytosis (GO:0048488)2.75439960
94regulation of female receptivity (GO:0045924)2.74479564
95regulation of neurotransmitter transport (GO:0051588)2.74023199
96regulation of glutamate secretion (GO:0014048)2.70478713
97potassium ion import (GO:0010107)2.69806785
98cell-cell junction maintenance (GO:0045217)2.69448700
99myelin maintenance (GO:0043217)2.69439887
100regulation of dendritic spine morphogenesis (GO:0061001)2.68983802
101membrane depolarization during action potential (GO:0086010)2.68689387
102axonal fasciculation (GO:0007413)2.68412858
103regulation of vesicle fusion (GO:0031338)2.68320364
104potassium ion homeostasis (GO:0055075)2.66192659
105dendrite morphogenesis (GO:0048813)2.65695952
106vesicle transport along microtubule (GO:0047496)2.64798350
107cell communication by electrical coupling (GO:0010644)2.63268552
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.63145941
109L-phenylalanine catabolic process (GO:0006559)2.63145941
110cell communication involved in cardiac conduction (GO:0086065)2.62943109
111female mating behavior (GO:0060180)2.62479113
112calcium ion-dependent exocytosis (GO:0017156)2.61430854
113membrane depolarization (GO:0051899)2.60530961
114fusion of sperm to egg plasma membrane (GO:0007342)2.59677231
115dicarboxylic acid transport (GO:0006835)2.58855939
116chemosensory behavior (GO:0007635)2.58184237
117positive regulation of neurotransmitter transport (GO:0051590)2.57946640
118neuromuscular process (GO:0050905)2.57569760
119L-glutamate transport (GO:0015813)2.57307236
120synaptic transmission (GO:0007268)2.56567630
121negative regulation of dendrite morphogenesis (GO:0050774)2.55553340
122positive regulation of synaptic transmission (GO:0050806)2.55096079
123establishment of mitochondrion localization (GO:0051654)2.54878690
124regulation of synaptic transmission (GO:0050804)2.54865003
125response to acidic pH (GO:0010447)2.52385518
126synapse assembly (GO:0007416)2.52312580
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52217784
128social behavior (GO:0035176)2.51532764
129intraspecies interaction between organisms (GO:0051703)2.51532764
130positive regulation of dendrite development (GO:1900006)2.49325044
131sexual reproduction (GO:0019953)2.47130232
132receptor recycling (GO:0001881)2.44643247
133regulation of dendritic spine development (GO:0060998)2.42253400
134cerebral cortex neuron differentiation (GO:0021895)2.39441289
135regulation of voltage-gated calcium channel activity (GO:1901385)2.37839539
136regulation of ARF GTPase activity (GO:0032312)2.37627360
137positive regulation of neurotransmitter secretion (GO:0001956)2.36496789
138actin filament capping (GO:0051693)2.35600267
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.35534275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16868663
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.36992082
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31191498
4GBX2_23144817_ChIP-Seq_PC3_Human2.94336357
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84093895
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82993901
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61394455
8REST_21632747_ChIP-Seq_MESCs_Mouse2.55410834
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48180785
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46216695
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46216695
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43721967
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.43384451
14DROSHA_22980978_ChIP-Seq_HELA_Human2.42162819
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39952325
16LXR_22292898_ChIP-Seq_THP-1_Human2.39181835
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32334556
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26845985
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25991226
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16685819
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.15073040
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.14879709
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.14079470
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.12824367
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10636198
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03501500
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.03249031
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.88600101
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88492136
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87231180
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80329437
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.71124013
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70443015
34TAF15_26573619_Chip-Seq_HEK293_Human1.69884631
35SMC4_20622854_ChIP-Seq_HELA_Human1.69129337
36* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65587986
37P68_20966046_ChIP-Seq_HELA_Human1.64109903
38AR_21572438_ChIP-Seq_LNCaP_Human1.62868394
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62337300
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58389863
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50866906
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48570206
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39741194
44SMAD4_21799915_ChIP-Seq_A2780_Human1.39475700
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37812937
46* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37382858
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.34012671
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33599503
49RACK7_27058665_Chip-Seq_MCF-7_Human1.33371638
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31110939
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30698144
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30664930
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30017158
54* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29881082
55* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28018436
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23677409
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23218351
58CREB1_26743006_Chip-Seq_LNCaP_Human1.22121456
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21757188
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19786088
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19784115
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.19554505
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19331645
64ZNF274_21170338_ChIP-Seq_K562_Hela1.18632165
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18302866
66TP63_22573176_ChIP-Seq_HFKS_Human1.18267072
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.18183955
68KDM2B_26808549_Chip-Seq_DND41_Human1.18081161
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17856198
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.17246848
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16999580
72OCT4_19829295_ChIP-Seq_ESCs_Human1.16947562
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.16814746
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14546162
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14290069
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13171674
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13153467
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11840817
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11747170
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.10395902
81SA1_27219007_Chip-Seq_Bcells_Human1.10384216
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.10344044
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09976369
84P300_19829295_ChIP-Seq_ESCs_Human1.08312748
85AR_19668381_ChIP-Seq_PC3_Human1.08299884
86BCOR_27268052_Chip-Seq_Bcells_Human1.08118516
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08101350
88STAT3_23295773_ChIP-Seq_U87_Human1.07136808
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07123911
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.05971854
91CTCF_20526341_ChIP-Seq_ESCs_Human1.05739122
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05039644
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04901030
94* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04745847
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04710179
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.04614712
97AR_25329375_ChIP-Seq_VCAP_Human1.04327115
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03147854
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02929443
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02341461
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.01667659
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00730578
103* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00611973
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.00573135
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99870420
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99175284
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98693559
108KDM2B_26808549_Chip-Seq_K562_Human0.98019784
109BCL6_27268052_Chip-Seq_Bcells_Human0.96835455
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96619902
111* RUNX1_27514584_Chip-Seq_MCF-7_Human0.96557584
112KLF4_19829295_ChIP-Seq_ESCs_Human0.96448117
113CTCF_27219007_Chip-Seq_Bcells_Human0.95439627
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94846538
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94786031
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.94247625
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94001587
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92941080
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.92636923
120TCF4_23295773_ChIP-Seq_U87_Human0.92267670
121AHR_22903824_ChIP-Seq_MCF-7_Human0.92249530
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91292702
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90643853
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90052890
125PHF8_20622854_ChIP-Seq_HELA_Human0.89656479
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.89487729
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88529827
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88055315
129E2F1_20622854_ChIP-Seq_HELA_Human0.87510621
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86094884
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85528551
132* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85391611
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85306714
134* RXR_22158963_ChIP-Seq_LIVER_Mouse0.84496713
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84334157
136RUNX2_22187159_ChIP-Seq_PCA_Human0.83799764
137* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83232792
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.83174938
139IGF1R_20145208_ChIP-Seq_DFB_Human0.83065408
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82999421
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.82845618
142TET1_21490601_ChIP-Seq_MESCs_Mouse0.82637126
143* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82109461
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.82084490
145SMAD4_21741376_ChIP-Seq_ESCs_Human0.81989322
146* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81816774
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81232869
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.81153368
149LXR_22158963_ChIP-Seq_LIVER_Mouse0.80565079
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79805558
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.79647388
152WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79551525
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78440318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.38858614
2MP0003880_abnormal_central_pattern4.47787547
3MP0003635_abnormal_synaptic_transmissio3.69488438
4MP0002822_catalepsy3.31075228
5MP0004270_analgesia3.24135705
6MP0009745_abnormal_behavioral_response3.18824159
7MP0002064_seizures3.07496252
8MP0009046_muscle_twitch2.92814395
9MP0002063_abnormal_learning/memory/cond2.89043646
10MP0005423_abnormal_somatic_nervous2.60713704
11MP0002272_abnormal_nervous_system2.60422940
12MP0001968_abnormal_touch/_nociception2.58311116
13MP0002572_abnormal_emotion/affect_behav2.49750654
14MP0001486_abnormal_startle_reflex2.43888062
15MP0002734_abnormal_mechanical_nocicepti2.29096147
16MP0005670_abnormal_white_adipose2.24140375
17MP0003329_amyloid_beta_deposits2.20243970
18MP0001501_abnormal_sleep_pattern2.20020619
19MP0001440_abnormal_grooming_behavior1.94467229
20MP0002736_abnormal_nociception_after1.92822384
21MP0003123_paternal_imprinting1.87180582
22MP0002139_abnormal_hepatobiliary_system1.84727802
23MP0005646_abnormal_pituitary_gland1.81671221
24MP0002733_abnormal_thermal_nociception1.80336914
25MP0002909_abnormal_adrenal_gland1.78494197
26MP0001970_abnormal_pain_threshold1.76181651
27MP0002067_abnormal_sensory_capabilities1.74379319
28MP0009780_abnormal_chondrocyte_physiolo1.72360642
29MP0008569_lethality_at_weaning1.70692595
30MP0001529_abnormal_vocalization1.69245794
31MP0004885_abnormal_endolymph1.66574342
32MP0006276_abnormal_autonomic_nervous1.66008619
33MP0004924_abnormal_behavior1.65271929
34MP0005386_behavior/neurological_phenoty1.65271929
35MP0004142_abnormal_muscle_tone1.63207820
36MP0002735_abnormal_chemical_nociception1.63201907
37MP0000566_synostosis1.58850113
38MP0002557_abnormal_social/conspecific_i1.56490625
39MP0001984_abnormal_olfaction1.52517335
40MP0003690_abnormal_glial_cell1.51377932
41MP0003633_abnormal_nervous_system1.49750094
42MP0000920_abnormal_myelination1.49491602
43MP0005085_abnormal_gallbladder_physiolo1.48950731
44MP0002184_abnormal_innervation1.47450006
45MP0000955_abnormal_spinal_cord1.46840189
46MP0001905_abnormal_dopamine_level1.45907007
47MP0004811_abnormal_neuron_physiology1.44432412
48MP0005645_abnormal_hypothalamus_physiol1.42623793
49MP0000778_abnormal_nervous_system1.42588245
50MP0003122_maternal_imprinting1.38770352
51MP0002066_abnormal_motor_capabilities/c1.37669222
52MP0001348_abnormal_lacrimal_gland1.37621142
53MP0004858_abnormal_nervous_system1.37446627
54MP0005360_urolithiasis1.36575511
55MP0003878_abnormal_ear_physiology1.36453683
56MP0005377_hearing/vestibular/ear_phenot1.36453683
57MP0001502_abnormal_circadian_rhythm1.28706845
58MP0008875_abnormal_xenobiotic_pharmacok1.27157185
59MP0002882_abnormal_neuron_morphology1.27102757
60MP0003631_nervous_system_phenotype1.24900066
61MP0000749_muscle_degeneration1.24275955
62MP0003879_abnormal_hair_cell1.23563134
63MP0002229_neurodegeneration1.19721705
64MP0000604_amyloidosis1.18374387
65MP0002249_abnormal_larynx_morphology1.15458492
66MP0008872_abnormal_physiological_respon1.14480447
67MP0005365_abnormal_bile_salt1.13894556
68MP0004036_abnormal_muscle_relaxation1.10635514
69MP0004043_abnormal_pH_regulation1.09687141
70MP0005535_abnormal_body_temperature1.08455178
71MP0005409_darkened_coat_color1.07401156
72MP0005551_abnormal_eye_electrophysiolog1.07126532
73MP0000678_abnormal_parathyroid_gland1.05570815
74MP0003698_abnormal_male_reproductive1.04122063
75MP0003787_abnormal_imprinting1.04118412
76MP0000013_abnormal_adipose_tissue1.02456317
77MP0002837_dystrophic_cardiac_calcinosis1.01503101
78MP0003634_abnormal_glial_cell1.01326199
79MP0003646_muscle_fatigue1.00798073
80MP0008874_decreased_physiological_sensi0.99991990
81MP0002069_abnormal_eating/drinking_beha0.99594562
82MP0004130_abnormal_muscle_cell0.95776256
83MP0004510_myositis0.95056112
84MP0003283_abnormal_digestive_organ0.95002081
85MP0001177_atelectasis0.94033942
86MP0000751_myopathy0.93990425
87MP0003075_altered_response_to0.93896792
88MP0003632_abnormal_nervous_system0.93653411
89MP0004233_abnormal_muscle_weight0.92178393
90MP0005083_abnormal_biliary_tract0.91984308
91MP0002152_abnormal_brain_morphology0.91453438
92MP0001346_abnormal_lacrimal_gland0.90760145
93MP0004145_abnormal_muscle_electrophysio0.90533682
94MP0003195_calcinosis0.89804042
95MP0002089_abnormal_postnatal_growth/wei0.88323119
96MP0004742_abnormal_vestibular_system0.87662938
97MP0002090_abnormal_vision0.86584938
98MP0008961_abnormal_basal_metabolism0.85110580
99MP0001299_abnormal_eye_distance/0.83192801
100MP0005451_abnormal_body_composition0.82105211
101MP0000026_abnormal_inner_ear0.81707093
102MP0005058_abnormal_lysosome_morphology0.81589861
103MP0005666_abnormal_adipose_tissue0.81318596
104MP0003705_abnormal_hypodermis_morpholog0.81265830
105MP0004087_abnormal_muscle_fiber0.80573810
106MP0010329_abnormal_lipoprotein_level0.80189775
107MP0004085_abnormal_heartbeat0.76561895
108MP0000759_abnormal_skeletal_muscle0.76498473
109MP0005167_abnormal_blood-brain_barrier0.76449651
110MP0003183_abnormal_peptide_metabolism0.76274666
111MP0000003_abnormal_adipose_tissue0.74200852
112MP0005410_abnormal_fertilization0.73396311
113MP0001963_abnormal_hearing_physiology0.71871393
114MP0005375_adipose_tissue_phenotype0.71054556
115MP0000750_abnormal_muscle_regeneration0.70698583
116MP0002269_muscular_atrophy0.70332419
117MP0002876_abnormal_thyroid_physiology0.70265361
118MP0001664_abnormal_digestion0.69936622
119MP0000747_muscle_weakness0.69305972
120MP0005332_abnormal_amino_acid0.69046579
121MP0001765_abnormal_ion_homeostasis0.68970602
122MP0000681_abnormal_thyroid_gland0.68522077
123MP0002106_abnormal_muscle_physiology0.68518923
124MP0002118_abnormal_lipid_homeostasis0.68265746
125MP0001666_abnormal_nutrient_absorption0.67372705
126MP0001485_abnormal_pinna_reflex0.67311266
127MP0002752_abnormal_somatic_nervous0.66886543
128MP0003137_abnormal_impulse_conducting0.65373338
129MP0005584_abnormal_enzyme/coenzyme_acti0.65368556
130MP0010386_abnormal_urinary_bladder0.64328842
131MP0000639_abnormal_adrenal_gland0.62536525
132MP0003252_abnormal_bile_duct0.62115812
133MP0005499_abnormal_olfactory_system0.61038800
134MP0005394_taste/olfaction_phenotype0.61038800

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.23643980
2Focal motor seizures (HP:0011153)6.21496349
3Focal seizures (HP:0007359)4.71133670
4Visual hallucinations (HP:0002367)4.51512541
5Supranuclear gaze palsy (HP:0000605)3.95183839
6Neurofibrillary tangles (HP:0002185)3.92035214
7Bundle branch block (HP:0011710)3.76768802
8Atonic seizures (HP:0010819)3.71745020
9Action tremor (HP:0002345)3.62815781
10Epileptic encephalopathy (HP:0200134)3.57303588
11Ankle clonus (HP:0011448)3.57007862
12Generalized tonic-clonic seizures (HP:0002069)3.52974178
13Absence seizures (HP:0002121)3.51294648
14Progressive cerebellar ataxia (HP:0002073)3.50382160
15Cerebral inclusion bodies (HP:0100314)3.44562400
16Dialeptic seizures (HP:0011146)3.22672140
17Anxiety (HP:0000739)3.18813177
18Febrile seizures (HP:0002373)3.18734125
19Dysmetria (HP:0001310)3.18080930
20Depression (HP:0000716)3.10640844
21Postural instability (HP:0002172)3.08533472
22Exercise-induced myalgia (HP:0003738)3.07639994
23Intention tremor (HP:0002080)3.00867452
24Torticollis (HP:0000473)3.00638847
25Dysdiadochokinesis (HP:0002075)2.99800465
26Spastic gait (HP:0002064)2.94195912
27Obstructive sleep apnea (HP:0002870)2.92820202
28Impaired vibration sensation in the lower limbs (HP:0002166)2.92781684
29Pheochromocytoma (HP:0002666)2.89899248
30Asymmetric septal hypertrophy (HP:0001670)2.85904175
31Abnormality of the corticospinal tract (HP:0002492)2.80868291
32Poor eye contact (HP:0000817)2.80399426
33Abnormal eating behavior (HP:0100738)2.80024563
34Focal dystonia (HP:0004373)2.78402932
35Scanning speech (HP:0002168)2.78345573
36Hyperventilation (HP:0002883)2.76816240
37Impaired social interactions (HP:0000735)2.73754064
38Abnormal social behavior (HP:0012433)2.73754064
39Urinary bladder sphincter dysfunction (HP:0002839)2.69957724
40Status epilepticus (HP:0002133)2.68970388
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68478697
42Craniofacial dystonia (HP:0012179)2.67628636
43Insidious onset (HP:0003587)2.65051656
44Termporal pattern (HP:0011008)2.65051656
45Hyporeflexia of lower limbs (HP:0002600)2.64123287
46Limb dystonia (HP:0002451)2.64006916
47Distal lower limb muscle weakness (HP:0009053)2.62769104
48Upper limb amyotrophy (HP:0009129)2.62196618
49Distal upper limb amyotrophy (HP:0007149)2.62196618
50Truncal ataxia (HP:0002078)2.60866088
51Urinary urgency (HP:0000012)2.60672455
52Heart block (HP:0012722)2.57590991
53Abnormal atrioventricular conduction (HP:0005150)2.56942070
54Hand muscle atrophy (HP:0009130)2.50642629
55Gaze-evoked nystagmus (HP:0000640)2.49894612
56Broad-based gait (HP:0002136)2.48391205
57Abnormality of the lower motor neuron (HP:0002366)2.46969276
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46671126
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.46671126
60Akinesia (HP:0002304)2.45944618
61Ventricular fibrillation (HP:0001663)2.41732468
62Neuroendocrine neoplasm (HP:0100634)2.41187092
63Cerebral hypomyelination (HP:0006808)2.41170881
64Mutism (HP:0002300)2.38169401
65Bradykinesia (HP:0002067)2.37887271
66Progressive inability to walk (HP:0002505)2.34431747
67Stridor (HP:0010307)2.34257934
68Sudden death (HP:0001699)2.34199029
69Agitation (HP:0000713)2.29963198
70Clonus (HP:0002169)2.28287158
71Lower limb muscle weakness (HP:0007340)2.27020406
72Hemiparesis (HP:0001269)2.26581047
73Hemiplegia (HP:0002301)2.25805484
74Type 1 muscle fiber predominance (HP:0003803)2.24042484
75Muscle fiber inclusion bodies (HP:0100299)2.21989026
76Epileptiform EEG discharges (HP:0011182)2.18464035
77EEG with generalized epileptiform discharges (HP:0011198)2.18324918
78Generalized myoclonic seizures (HP:0002123)2.17836822
79Foot dorsiflexor weakness (HP:0009027)2.16198244
80Lower limb amyotrophy (HP:0007210)2.15558713
81Myopathic facies (HP:0002058)2.13950683
82Muscle fiber splitting (HP:0003555)2.13668001
83Hypsarrhythmia (HP:0002521)2.13132989
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.12778780
85Rigidity (HP:0002063)2.11034859
86Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10755261
87Excessive salivation (HP:0003781)2.09845782
88Drooling (HP:0002307)2.09845782
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08730414
90Nemaline bodies (HP:0003798)2.08379738
91Psychosis (HP:0000709)2.08007928
92Neuronal loss in central nervous system (HP:0002529)2.07738221
93Megalencephaly (HP:0001355)2.07198513
94Hyperkalemia (HP:0002153)2.05325593
95Amblyopia (HP:0000646)2.03998118
96Abnormality of saccadic eye movements (HP:0000570)2.03934863
97Impaired vibratory sensation (HP:0002495)2.03206657
98Double outlet right ventricle (HP:0001719)2.03156697
99Congenital malformation of the right heart (HP:0011723)2.03156697
100Peripheral hypomyelination (HP:0007182)2.01781796
101Papilledema (HP:0001085)2.01712610
102Deep venous thrombosis (HP:0002625)2.00680557
103Fetal akinesia sequence (HP:0001989)1.98264618
104Retinal dysplasia (HP:0007973)1.97415874
105Abnormality of the foot musculature (HP:0001436)1.97328300
106Morphological abnormality of the pyramidal tract (HP:0002062)1.96874727
107Axonal loss (HP:0003447)1.96571060
108Polyphagia (HP:0002591)1.96377474
109EMG: myopathic abnormalities (HP:0003458)1.95289982
110Cholecystitis (HP:0001082)1.94751149
111Abnormal gallbladder physiology (HP:0012438)1.94751149
112Blue irides (HP:0000635)1.92390851
113Distal lower limb amyotrophy (HP:0008944)1.92364922
114Delusions (HP:0000746)1.92144178
115Spastic tetraparesis (HP:0001285)1.91713351
116Impaired smooth pursuit (HP:0007772)1.91006232
117Exercise-induced muscle cramps (HP:0003710)1.90190676
118Genetic anticipation (HP:0003743)1.89871222
119Gait ataxia (HP:0002066)1.88655319
120Onion bulb formation (HP:0003383)1.87214813
121Insomnia (HP:0100785)1.87050596
122Syncope (HP:0001279)1.86387568
123Ventricular tachycardia (HP:0004756)1.84734872
124Postural tremor (HP:0002174)1.84706985
125Spinal rigidity (HP:0003306)1.84497764
126Tetraplegia (HP:0002445)1.84036882
127Bell-shaped thorax (HP:0001591)1.83584687
128Resting tremor (HP:0002322)1.81607724
129Hyperlipoproteinemia (HP:0010980)1.81066655
130Abnormality of binocular vision (HP:0011514)1.79948561
131Diplopia (HP:0000651)1.79948561
132Increased circulating renin level (HP:0000848)1.79888221
133Choreoathetosis (HP:0001266)1.79860614
134Myoglobinuria (HP:0002913)1.78590217
135Cerebral hemorrhage (HP:0001342)1.75835271
136Bowel incontinence (HP:0002607)1.75301127
137Hyperthyroidism (HP:0000836)1.75219612
138Turricephaly (HP:0000262)1.74958256
139Rapidly progressive (HP:0003678)1.74798899
140Aplasia involving bones of the upper limbs (HP:0009823)1.73549909
141Aplasia of the phalanges of the hand (HP:0009802)1.73549909
142Aplasia involving bones of the extremities (HP:0009825)1.73549909
143Anosmia (HP:0000458)1.72989196
144Abnormality of the periventricular white matter (HP:0002518)1.72467835
145Failure to thrive in infancy (HP:0001531)1.71700634
146Decreased motor nerve conduction velocity (HP:0003431)1.71320017
147Abnormality of the aortic arch (HP:0012303)1.71234514
148Bronchomalacia (HP:0002780)1.70066983
149Muscle stiffness (HP:0003552)1.69843334
150Rhabdomyolysis (HP:0003201)1.69625220
151Mildly elevated creatine phosphokinase (HP:0008180)1.67848898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.88660198
2EPHA43.73427042
3MAP3K93.54459849
4TESK13.45155748
5MAP3K42.89217186
6RIPK12.52325654
7DAPK22.41582333
8MINK12.40860640
9MARK12.32655253
10PRKD32.29386015
11MAP2K72.24037827
12NTRK12.17685135
13PAK62.16632877
14MAP2K42.13656000
15TRIB32.05338769
16NTRK22.04720919
17KSR22.00726443
18DDR21.79845081
19CAMKK11.67334480
20MAP3K121.61573106
21OXSR11.59594841
22UHMK11.54406769
23STK391.54078784
24CDK51.51726562
25CDK191.50428498
26ARAF1.44262722
27GRK51.38799746
28SIK11.35907783
29PNCK1.35215761
30STK381.33349889
31SGK4941.32502780
32SGK2231.32502780
33TYRO31.29771460
34PINK11.28196538
35MAP3K21.26502534
36MAP3K131.25702409
37PRKCG1.21467135
38MAP3K111.20187974
39TNIK1.19741841
40FES1.19045431
41OBSCN1.18420873
42LIMK11.17732631
43CASK1.17454344
44DYRK1B1.16623069
45PHKG21.14792955
46PHKG11.14792955
47LMTK21.13356994
48RIPK41.12153753
49EPHA21.11533218
50MAPKAPK51.07598757
51CAMK2A1.07477816
52CAMK2B1.07240576
53PRKCH1.06094765
54KSR11.02072030
55WNK11.01493923
56WNK41.01223128
57MAPK150.99934005
58BRAF0.99060703
59TTN0.96226545
60MAPK130.95056819
61PAK30.93368989
62DAPK10.92901112
63PLK20.92398813
64PRPF4B0.91295864
65STK110.90757768
66CAMK2G0.90464123
67RET0.90098543
68CSNK1G20.89283634
69TNK20.87667244
70CDK150.85594663
71FGFR20.84886537
72SIK20.84256416
73CDK180.83973538
74CDK140.83794446
75CAMKK20.83525156
76CAMK10.83236218
77MAPK120.81898941
78PDPK10.81291997
79CAMK2D0.81083116
80MAP3K10.75441093
81PRKG20.74051649
82CDK11A0.72900481
83PKN10.70513070
84PDK10.70428990
85RPS6KA20.70350239
86MST1R0.69853983
87ROCK10.68923384
88FGFR40.67674407
89MARK20.67605658
90PDGFRA0.66076703
91SGK30.65496034
92TAOK10.64834989
93PRKCZ0.64664950
94DMPK0.63827240
95SGK20.62501594
96CAMK1G0.61082360
97LATS20.60980110
98NEK60.60655287
99SGK10.60122504
100BRSK10.59309429
101FER0.59146198
102DYRK1A0.57366883
103PTK2B0.56688756
104WNK30.56076369
105ALK0.54606726
106ROCK20.54591785
107PRKCE0.54160186
108MAP3K70.53645435
109ICK0.52510203
110CDC42BPA0.52381909
111RPS6KA30.51977675
112EEF2K0.50780916
113PTK20.50004195
114BCR0.49989381
115CSNK1G30.48840253
116FYN0.48059824
117MAPK100.44746786
118MUSK0.43707080
119MAP2K10.43428570
120DAPK30.42307739
121PRKG10.42044386
122MET0.41626263
123EPHA30.39492092
124CAMK40.39023556
125ERBB20.38899771
126PLK40.38100976
127MAPKAPK30.37518488
128PRKAA10.37221358
129PRKD10.37160439
130FGR0.36989939
131BMPR20.36864670

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.25521110
2Nicotine addiction_Homo sapiens_hsa050332.97807236
3Synaptic vesicle cycle_Homo sapiens_hsa047212.92233899
4GABAergic synapse_Homo sapiens_hsa047272.58331473
5Olfactory transduction_Homo sapiens_hsa047402.27592771
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16513032
7Circadian entrainment_Homo sapiens_hsa047132.12190407
8Glutamatergic synapse_Homo sapiens_hsa047242.09996631
9Morphine addiction_Homo sapiens_hsa050322.05888940
10Amphetamine addiction_Homo sapiens_hsa050312.00082548
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94838537
12Long-term potentiation_Homo sapiens_hsa047201.87164705
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79136195
14Insulin secretion_Homo sapiens_hsa049111.78199208
15Arginine and proline metabolism_Homo sapiens_hsa003301.76956975
16Dopaminergic synapse_Homo sapiens_hsa047281.75421070
17Salivary secretion_Homo sapiens_hsa049701.73909142
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69254844
19Cocaine addiction_Homo sapiens_hsa050301.65398806
20Gastric acid secretion_Homo sapiens_hsa049711.56783726
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55717819
22Arginine biosynthesis_Homo sapiens_hsa002201.53623174
23Taste transduction_Homo sapiens_hsa047421.47783789
24Butanoate metabolism_Homo sapiens_hsa006501.47239343
25Cholinergic synapse_Homo sapiens_hsa047251.47217321
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47207577
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.45548067
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43990534
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41792198
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39249980
31Collecting duct acid secretion_Homo sapiens_hsa049661.35324524
32Renin secretion_Homo sapiens_hsa049241.35009360
33Serotonergic synapse_Homo sapiens_hsa047261.33473489
34Bile secretion_Homo sapiens_hsa049761.29093085
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28914675
36Long-term depression_Homo sapiens_hsa047301.26353454
37Calcium signaling pathway_Homo sapiens_hsa040201.14389008
38Oxytocin signaling pathway_Homo sapiens_hsa049211.08545726
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04165824
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01202994
41GnRH signaling pathway_Homo sapiens_hsa049121.00593584
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96946428
43Gap junction_Homo sapiens_hsa045400.96902798
44cAMP signaling pathway_Homo sapiens_hsa040240.93712630
45Type II diabetes mellitus_Homo sapiens_hsa049300.91729671
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91688659
47Pancreatic secretion_Homo sapiens_hsa049720.89614156
48VEGF signaling pathway_Homo sapiens_hsa043700.88122002
49Cardiac muscle contraction_Homo sapiens_hsa042600.87885862
50Vibrio cholerae infection_Homo sapiens_hsa051100.86102713
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84776691
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84571181
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81896277
54Endocytosis_Homo sapiens_hsa041440.81502694
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80526335
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79003103
57Insulin signaling pathway_Homo sapiens_hsa049100.78578342
58Estrogen signaling pathway_Homo sapiens_hsa049150.78248180
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76830055
60Inositol phosphate metabolism_Homo sapiens_hsa005620.76517170
61Thyroid hormone synthesis_Homo sapiens_hsa049180.73818307
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71853479
63Biosynthesis of amino acids_Homo sapiens_hsa012300.71841115
64Fatty acid elongation_Homo sapiens_hsa000620.71327442
65Tight junction_Homo sapiens_hsa045300.71306880
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71059059
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70883255
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69155407
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69022434
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.68843419
71Axon guidance_Homo sapiens_hsa043600.68526864
72AMPK signaling pathway_Homo sapiens_hsa041520.67004743
73Melanogenesis_Homo sapiens_hsa049160.66853196
74Sulfur relay system_Homo sapiens_hsa041220.66011566
75Propanoate metabolism_Homo sapiens_hsa006400.63780573
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63619244
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63256995
78Prion diseases_Homo sapiens_hsa050200.61839831
79Carbon metabolism_Homo sapiens_hsa012000.60904452
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.60573841
81Tryptophan metabolism_Homo sapiens_hsa003800.60160140
82Dorso-ventral axis formation_Homo sapiens_hsa043200.58723165
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.57432989
84Fructose and mannose metabolism_Homo sapiens_hsa000510.57265458
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57052709
86ErbB signaling pathway_Homo sapiens_hsa040120.56407379
87Vitamin B6 metabolism_Homo sapiens_hsa007500.54980053
88Glioma_Homo sapiens_hsa052140.54277386
89Sulfur metabolism_Homo sapiens_hsa009200.54169688
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54049682
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54028145
92Fatty acid metabolism_Homo sapiens_hsa012120.53939861
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53854455
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.53713987
95Circadian rhythm_Homo sapiens_hsa047100.53513051
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53411481
97Pyruvate metabolism_Homo sapiens_hsa006200.53397835
98Phototransduction_Homo sapiens_hsa047440.52912517
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.52441432
100Glucagon signaling pathway_Homo sapiens_hsa049220.51047833
101Mineral absorption_Homo sapiens_hsa049780.50983193
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.50982155
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50878731
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50849559
105Histidine metabolism_Homo sapiens_hsa003400.50155557
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.49687462
107Phenylalanine metabolism_Homo sapiens_hsa003600.48450936
108Alzheimers disease_Homo sapiens_hsa050100.46798440
109beta-Alanine metabolism_Homo sapiens_hsa004100.45141535
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45078454
111PPAR signaling pathway_Homo sapiens_hsa033200.43742532
112Oxidative phosphorylation_Homo sapiens_hsa001900.42919241
113Glycerolipid metabolism_Homo sapiens_hsa005610.42908626
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.42200081
115Fatty acid degradation_Homo sapiens_hsa000710.40883921
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40676213
117Dilated cardiomyopathy_Homo sapiens_hsa054140.39536670
118Fatty acid biosynthesis_Homo sapiens_hsa000610.38098283
119Tyrosine metabolism_Homo sapiens_hsa003500.37785304
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37011653
121Ovarian steroidogenesis_Homo sapiens_hsa049130.36048275
122Choline metabolism in cancer_Homo sapiens_hsa052310.34994503
123Parkinsons disease_Homo sapiens_hsa050120.33812020
124ABC transporters_Homo sapiens_hsa020100.32282337
125MAPK signaling pathway_Homo sapiens_hsa040100.30997138
126Peroxisome_Homo sapiens_hsa041460.30086720
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29866730

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