ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	5.39350495
2	presynaptic membrane organization (GO:0097090)	4.86906298
3	pyrimidine nucleobase catabolic process (GO:0006208)	4.72607218
4	C4-dicarboxylate transport (GO:0015740)	4.38182525
5	auditory behavior (GO:0031223)	4.33492245
6	ubiquinone metabolic process (GO:0006743)	4.28683207
7	piRNA metabolic process (GO:0034587)	4.15927946
8	mechanosensory behavior (GO:0007638)	4.12803116
9	protein localization to cilium (GO:0061512)	4.09343190
10	ubiquinone biosynthetic process (GO:0006744)	4.03367227
11	cerebral cortex radially oriented cell migration (GO:0021799)	3.98836313
12	nucleobase catabolic process (GO:0046113)	3.98543488
13	intraciliary transport (GO:0042073)	3.67455441
14	meiotic chromosome segregation (GO:0045132)	3.67158439
15	neuron cell-cell adhesion (GO:0007158)	3.53795178
16	substrate-independent telencephalic tangential migration (GO:0021826)	3.53008942
17	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.53008942
18	nonmotile primary cilium assembly (GO:0035058)	3.50678493
19	cerebral cortex cell migration (GO:0021795)	3.47826401
20	quinone biosynthetic process (GO:1901663)	3.34581923
21	vocalization behavior (GO:0071625)	3.33863805
22	cilium morphogenesis (GO:0060271)	3.29169300
23	epithelial cilium movement (GO:0003351)	3.27368839
24	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.26885139
25	neuronal action potential propagation (GO:0019227)	3.14533428
26	axonal fasciculation (GO:0007413)	3.08460889
27	retinal cone cell development (GO:0046549)	3.06651209
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.06602442
29	response to nitrosative stress (GO:0051409)	3.05532860
30	postsynaptic membrane organization (GO:0001941)	3.02292069
31	startle response (GO:0001964)	3.02203161
32	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.00687825
33	adaptation of signaling pathway (GO:0023058)	2.99463128
34	resolution of meiotic recombination intermediates (GO:0000712)	2.97222808
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.94072672
36	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.94072672
37	regulation of translation, ncRNA-mediated (GO:0045974)	2.94072672
38	protein prenylation (GO:0018342)	2.92463068
39	prenylation (GO:0097354)	2.92463068
40	cilium organization (GO:0044782)	2.91654004
41	cilium assembly (GO:0042384)	2.91531440
42	neurotransmitter-gated ion channel clustering (GO:0072578)	2.90744494
43	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.89243357
44	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.86753298
45	olfactory bulb development (GO:0021772)	2.83218110
46	glutamate receptor signaling pathway (GO:0007215)	2.78519815
47	neuron recognition (GO:0008038)	2.78353502
48	DNA methylation involved in gamete generation (GO:0043046)	2.78224173
49	behavioral response to nicotine (GO:0035095)	2.78156205
50	brain morphogenesis (GO:0048854)	2.77803818
51	cilium movement (GO:0003341)	2.76703768
52	neurotransmitter uptake (GO:0001504)	2.76602882
53	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.75987534
54	positive regulation of amino acid transport (GO:0051957)	2.73540498
55	serotonin metabolic process (GO:0042428)	2.72202929
56	negative regulation of neurotransmitter transport (GO:0051589)	2.71761478
57	protein-cofactor linkage (GO:0018065)	2.70982399
58	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.70143943
59	proline transport (GO:0015824)	2.69864009
60	negative regulation of astrocyte differentiation (GO:0048712)	2.65464086
61	protein localization to synapse (GO:0035418)	2.63818651
62	limb bud formation (GO:0060174)	2.63673309
63	synaptic vesicle maturation (GO:0016188)	2.62979342
64	telencephalon cell migration (GO:0022029)	2.61335599
65	response to pheromone (GO:0019236)	2.59533559
66	microtubule depolymerization (GO:0007019)	2.59298934
67	photoreceptor cell development (GO:0042461)	2.56523149
68	synaptic transmission, glutamatergic (GO:0035249)	2.56361687
69	smoothened signaling pathway (GO:0007224)	2.55879619
70	central nervous system projection neuron axonogenesis (GO:0021952)	2.54972762
71	axoneme assembly (GO:0035082)	2.54366725
72	dorsal/ventral axis specification (GO:0009950)	2.54247826
73	photoreceptor cell maintenance (GO:0045494)	2.54027463
74	L-glutamate transport (GO:0015813)	2.53797758
75	forebrain cell migration (GO:0021885)	2.53683816
76	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.52420253
77	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.52347272
78	eye photoreceptor cell development (GO:0042462)	2.51336492
79	retinal ganglion cell axon guidance (GO:0031290)	2.49879281
80	L-fucose catabolic process (GO:0042355)	2.47850226
81	fucose catabolic process (GO:0019317)	2.47850226
82	L-fucose metabolic process (GO:0042354)	2.47850226
83	acidic amino acid transport (GO:0015800)	2.46864196
84	protein K11-linked deubiquitination (GO:0035871)	2.46687107
85	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.45729682
86	protein polyglutamylation (GO:0018095)	2.45027063
87	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.44846183
88	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.44846183
89	response to auditory stimulus (GO:0010996)	2.44577415
90	reciprocal DNA recombination (GO:0035825)	2.38455074
91	reciprocal meiotic recombination (GO:0007131)	2.38455074
92	vitamin biosynthetic process (GO:0009110)	2.37930065
93	regulation of cilium movement (GO:0003352)	2.37490191
94	regulation of collateral sprouting (GO:0048670)	2.37296752
95	replication fork processing (GO:0031297)	2.36824211
96	detection of light stimulus involved in sensory perception (GO:0050962)	2.36239243
97	detection of light stimulus involved in visual perception (GO:0050908)	2.36239243
98	regulation of timing of cell differentiation (GO:0048505)	2.35816884
99	primary amino compound metabolic process (GO:1901160)	2.35638507
100	cell proliferation in forebrain (GO:0021846)	2.35453683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.58893728
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.48249847
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.25714767
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.15777980
5	VDR_22108803_ChIP-Seq_LS180_Human	3.07668554
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97367390
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.84363734
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82642127
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75431241
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.72596952
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.48888419
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.45610730
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41137101
14	FUS_26573619_Chip-Seq_HEK293_Human	2.21031507
15	P300_19829295_ChIP-Seq_ESCs_Human	2.20367608
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18209826
17	EWS_26573619_Chip-Seq_HEK293_Human	2.14654179
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07870411
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.01669254
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92577995
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90478286
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.86552745
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82573276
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80717003
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80140135
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.72178672
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.71507392
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66735654
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.65793845
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63426587
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63426587
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63322497
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62716771
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.60560613
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.60532511
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60532511
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59714205
38	STAT3_23295773_ChIP-Seq_U87_Human	1.57305193
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57170833
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57084992
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56948815
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55469569
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54511963
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54046041
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53755976
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52018968
47	TCF4_23295773_ChIP-Seq_U87_Human	1.46441653
48	AR_25329375_ChIP-Seq_VCAP_Human	1.43547877
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40830020
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.39111513
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37637728
52	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37313518
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36682158
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31527697
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31310370
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31057157
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27284452
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23062088
59	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22221095
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21741933
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19096473
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17789199
63	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17013355
64	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16163528
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16038881
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16036336
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14807036
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13824499
69	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.13572436
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12423245
71	TP53_16413492_ChIP-PET_HCT116_Human	1.12026720
72	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10918702
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10573946
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10411917
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09204763
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08229209
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07906655
78	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07696888
79	JUN_21703547_ChIP-Seq_K562_Human	1.07341931
80	TP53_22573176_ChIP-Seq_HFKS_Human	1.07066546
81	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06748863
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06433253
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06194212
84	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05772605
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04925353
86	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04343543
87	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03636459
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03183922
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00832843
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.99918670
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99559959
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99276975
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99142743
94	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.97286528
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.96857164
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96661631
97	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.96444274
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95321382
99	AR_21572438_ChIP-Seq_LNCaP_Human	0.95161739
100	RXR_22108803_ChIP-Seq_LS180_Human	0.94315493

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.05933788
2	MP0001968_abnormal_touch/_nociception	2.88081345
3	MP0002638_abnormal_pupillary_reflex	2.64230475
4	MP0008877_abnormal_DNA_methylation	2.53102231
5	MP0009046_muscle_twitch	2.36355611
6	MP0004270_analgesia	2.30018014
7	MP0002102_abnormal_ear_morphology	2.18293398
8	MP0001984_abnormal_olfaction	2.14716160
9	MP0005394_taste/olfaction_phenotype	2.05887852
10	MP0005499_abnormal_olfactory_system	2.05887852
11	MP0005551_abnormal_eye_electrophysiolog	2.04752107
12	MP0000566_synostosis	1.98261397
13	MP0004885_abnormal_endolymph	1.97838701
14	MP0002938_white_spotting	1.93104462
15	MP0005253_abnormal_eye_physiology	1.92274064
16	MP0000569_abnormal_digit_pigmentation	1.91040514
17	MP0008789_abnormal_olfactory_epithelium	1.89807755
18	MP0003787_abnormal_imprinting	1.89183657
19	MP0006276_abnormal_autonomic_nervous	1.88142363
20	MP0006072_abnormal_retinal_apoptosis	1.85545866
21	MP0003136_yellow_coat_color	1.82780364
22	MP0003880_abnormal_central_pattern	1.82669015
23	MP0002735_abnormal_chemical_nociception	1.78898711
24	MP0009745_abnormal_behavioral_response	1.77184800
25	MP0002734_abnormal_mechanical_nocicepti	1.77107780
26	MP0002272_abnormal_nervous_system	1.72836058
27	MP0008058_abnormal_DNA_repair	1.70604651
28	MP0002572_abnormal_emotion/affect_behav	1.69279524
29	MP0000778_abnormal_nervous_system	1.69176808
30	MP0003635_abnormal_synaptic_transmissio	1.65406148
31	MP0001486_abnormal_startle_reflex	1.63099314
32	MP0000631_abnormal_neuroendocrine_gland	1.61789460
33	MP0000372_irregular_coat_pigmentation	1.57496443
34	MP0005423_abnormal_somatic_nervous	1.55354066
35	MP0006292_abnormal_olfactory_placode	1.53339467
36	MP0005187_abnormal_penis_morphology	1.49947112
37	MP0001986_abnormal_taste_sensitivity	1.48441829
38	MP0001501_abnormal_sleep_pattern	1.48301015
39	MP0002822_catalepsy	1.48086492
40	MP0003890_abnormal_embryonic-extraembry	1.48059443
41	MP0002063_abnormal_learning/memory/cond	1.47925898
42	MP0002064_seizures	1.47751846
43	MP0002067_abnormal_sensory_capabilities	1.37757137
44	MP0001970_abnormal_pain_threshold	1.35993255
45	MP0002909_abnormal_adrenal_gland	1.34667428
46	MP0005386_behavior/neurological_phenoty	1.30694552
47	MP0004924_abnormal_behavior	1.30694552
48	MP0002557_abnormal_social/conspecific_i	1.30385648
49	MP0001485_abnormal_pinna_reflex	1.29185685
50	MP0001502_abnormal_circadian_rhythm	1.28878349
51	MP0002733_abnormal_thermal_nociception	1.26764324
52	MP0000383_abnormal_hair_follicle	1.25602435
53	MP0000427_abnormal_hair_cycle	1.25558713
54	MP0008872_abnormal_physiological_respon	1.19844080
55	MP0005171_absent_coat_pigmentation	1.13909734
56	MP0005174_abnormal_tail_pigmentation	1.13631202
57	MP0001529_abnormal_vocalization	1.13561129
58	MP0002233_abnormal_nose_morphology	1.13417589
59	MP0003121_genomic_imprinting	1.12267334
60	MP0003633_abnormal_nervous_system	1.12031681
61	MP0003195_calcinosis	1.11003158
62	MP0001188_hyperpigmentation	1.06914048
63	MP0000955_abnormal_spinal_cord	1.05308406
64	MP0002882_abnormal_neuron_morphology	1.05145612
65	MP0003122_maternal_imprinting	1.04437987
66	MP0002184_abnormal_innervation	1.03995384
67	MP0002210_abnormal_sex_determination	0.99974341
68	MP0003011_delayed_dark_adaptation	0.97746606
69	MP0003698_abnormal_male_reproductive	0.96477763
70	MP0002752_abnormal_somatic_nervous	0.95412890
71	MP0005645_abnormal_hypothalamus_physiol	0.94142145
72	MP0005248_abnormal_Harderian_gland	0.94132081
73	MP0005646_abnormal_pituitary_gland	0.93639978
74	MP0003937_abnormal_limbs/digits/tail_de	0.93523310
75	MP0004859_abnormal_synaptic_plasticity	0.93489724
76	MP0005391_vision/eye_phenotype	0.93248662
77	MP0002751_abnormal_autonomic_nervous	0.93189968
78	MP0001929_abnormal_gametogenesis	0.92845167
79	MP0003119_abnormal_digestive_system	0.91299462
80	MP0004742_abnormal_vestibular_system	0.88294519
81	MP0005195_abnormal_posterior_eye	0.88284911
82	MP0010030_abnormal_orbit_morphology	0.87359589
83	MP0000647_abnormal_sebaceous_gland	0.85432963
84	MP0003631_nervous_system_phenotype	0.84765920
85	MP0002234_abnormal_pharynx_morphology	0.84173698
86	MP0002163_abnormal_gland_morphology	0.83247398
87	MP0005379_endocrine/exocrine_gland_phen	0.82561229
88	MP0002229_neurodegeneration	0.82538636
89	MP0004145_abnormal_muscle_electrophysio	0.81815158
90	MP0002152_abnormal_brain_morphology	0.79993232
91	MP0001324_abnormal_eye_pigmentation	0.79784344
92	MP0002066_abnormal_motor_capabilities/c	0.79097278
93	MP0010094_abnormal_chromosome_stability	0.78434881
94	MP0000516_abnormal_urinary_system	0.78338835
95	MP0005367_renal/urinary_system_phenotyp	0.78338835
96	MP0002095_abnormal_skin_pigmentation	0.78204541
97	MP0003755_abnormal_palate_morphology	0.77762017
98	MP0004142_abnormal_muscle_tone	0.77285662
99	MP0003718_maternal_effect	0.75979980
100	MP0001145_abnormal_male_reproductive	0.74243220

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	5.07087595
2	Hyperventilation (HP:0002883)	4.81388839
3	Abnormality of the labia minora (HP:0012880)	3.68098166
4	Focal motor seizures (HP:0011153)	3.39187029
5	Pancreatic fibrosis (HP:0100732)	3.36632580
6	Broad distal phalanx of finger (HP:0009836)	3.17764473
7	Medial flaring of the eyebrow (HP:0010747)	3.10044380
8	Septo-optic dysplasia (HP:0100842)	3.02692108
9	Optic nerve hypoplasia (HP:0000609)	3.02544848
10	Hemiparesis (HP:0001269)	2.86763641
11	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.86761184
12	Nephronophthisis (HP:0000090)	2.86310777
13	Pancreatic cysts (HP:0001737)	2.85700899
14	Molar tooth sign on MRI (HP:0002419)	2.84117774
15	Abnormality of midbrain morphology (HP:0002418)	2.84117774
16	True hermaphroditism (HP:0010459)	2.81625731
17	Colon cancer (HP:0003003)	2.79935058
18	Polyphagia (HP:0002591)	2.72711002
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71239524
20	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.66580735
21	Gait imbalance (HP:0002141)	2.64473770
22	Genital tract atresia (HP:0001827)	2.58491103
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.54886212
24	Congenital primary aphakia (HP:0007707)	2.50591237
25	Volvulus (HP:0002580)	2.47291144
26	Protruding tongue (HP:0010808)	2.47261633
27	Amyotrophic lateral sclerosis (HP:0007354)	2.43718156
28	Drooling (HP:0002307)	2.42473215
29	Lissencephaly (HP:0001339)	2.41496476
30	Postaxial foot polydactyly (HP:0001830)	2.41495944
31	Chronic hepatic failure (HP:0100626)	2.39536124
32	Absent speech (HP:0001344)	2.39268685
33	Broad-based gait (HP:0002136)	2.35764645
34	Limb dystonia (HP:0002451)	2.35458896
35	Tubulointerstitial abnormality (HP:0001969)	2.33876579
36	Febrile seizures (HP:0002373)	2.32279032
37	Nephrogenic diabetes insipidus (HP:0009806)	2.31284426
38	Small hand (HP:0200055)	2.28876241
39	Gaze-evoked nystagmus (HP:0000640)	2.28293929
40	Vaginal atresia (HP:0000148)	2.27832975
41	Abnormality of the renal medulla (HP:0100957)	2.26526329
42	Stomach cancer (HP:0012126)	2.24699728
43	Short tibia (HP:0005736)	2.24020538
44	Progressive inability to walk (HP:0002505)	2.22889264
45	Cutaneous finger syndactyly (HP:0010554)	2.18753490
46	Excessive salivation (HP:0003781)	2.16539726
47	Progressive cerebellar ataxia (HP:0002073)	2.13762454
48	Intestinal atresia (HP:0011100)	2.13079417
49	Methylmalonic acidemia (HP:0002912)	2.12315497
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11990494
51	Abolished electroretinogram (ERG) (HP:0000550)	2.10840814
52	Hip dysplasia (HP:0001385)	2.10784304
53	Postaxial hand polydactyly (HP:0001162)	2.10592350
54	Dialeptic seizures (HP:0011146)	2.09333225
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.09107716
56	Pachygyria (HP:0001302)	2.06996907
57	Growth hormone deficiency (HP:0000824)	2.04809707
58	3-Methylglutaconic aciduria (HP:0003535)	2.04790893
59	Renal hypoplasia (HP:0000089)	2.04708987
60	Short foot (HP:0001773)	2.03791172
61	Decreased circulating renin level (HP:0003351)	1.99932474
62	Hyperglycinuria (HP:0003108)	1.99389268
63	Pendular nystagmus (HP:0012043)	1.97065457
64	Abnormality of the astrocytes (HP:0100707)	1.96989097
65	Astrocytoma (HP:0009592)	1.96989097
66	Gastrointestinal atresia (HP:0002589)	1.95443813
67	Thin upper lip vermilion (HP:0000219)	1.94068977
68	Tented upper lip vermilion (HP:0010804)	1.92801318
69	Focal seizures (HP:0007359)	1.92659855
70	Astigmatism (HP:0000483)	1.90931841
71	Hyperglycinemia (HP:0002154)	1.90794038
72	Glioma (HP:0009733)	1.89325343
73	Cystic liver disease (HP:0006706)	1.89294763
74	Widely spaced teeth (HP:0000687)	1.89073382
75	Epileptic encephalopathy (HP:0200134)	1.86469565
76	Type II lissencephaly (HP:0007260)	1.85014887
77	Attenuation of retinal blood vessels (HP:0007843)	1.82813243
78	Prominent nasal bridge (HP:0000426)	1.82701930
79	Decreased testicular size (HP:0008734)	1.81926034
80	Agnosia (HP:0010524)	1.81631325
81	Dyschromatopsia (HP:0007641)	1.81006023
82	Renal cortical cysts (HP:0000803)	1.77999309
83	Cutaneous syndactyly (HP:0012725)	1.77494842
84	Abnormality of the renal cortex (HP:0011035)	1.73728514
85	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.73704541
86	Poor coordination (HP:0002370)	1.73250168
87	Hemiplegia (HP:0002301)	1.72623765
88	Preaxial hand polydactyly (HP:0001177)	1.72581278
89	Preaxial foot polydactyly (HP:0001841)	1.71653588
90	Abnormality of glycine metabolism (HP:0010895)	1.71536037
91	Abnormality of serine family amino acid metabolism (HP:0010894)	1.71536037
92	Anencephaly (HP:0002323)	1.70294795
93	Agitation (HP:0000713)	1.68066090
94	Specific learning disability (HP:0001328)	1.67820366
95	Sclerocornea (HP:0000647)	1.66463857
96	Inability to walk (HP:0002540)	1.65746460
97	Atonic seizures (HP:0010819)	1.64551091
98	Prominent supraorbital ridges (HP:0000336)	1.63249577
99	Generalized myoclonic seizures (HP:0002123)	1.63090918
100	Adrenal hypoplasia (HP:0000835)	1.62706516

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.48933916
2	FRK	3.96907682
3	WNK3	3.64257082
4	BMPR1B	2.75966135
5	PDK2	2.72441506
6	MAP3K4	2.71044793
7	NTRK3	2.58345568
8	MARK1	2.54215806
9	MAPK13	2.46457228
10	ACVR1B	2.27758586
11	TNIK	2.05856840
12	MKNK2	1.92306985
13	PINK1	1.90188655
14	DYRK2	1.81181733
15	MAP4K2	1.79593436
16	TIE1	1.73075688
17	MAP2K7	1.71157401
18	ZAK	1.70525900
19	CSNK1G1	1.61315537
20	PAK3	1.41568435
21	NUAK1	1.35754330
22	TAOK1	1.34418898
23	CCNB1	1.28328951
24	WEE1	1.24790137
25	PNCK	1.22119556
26	GRK1	1.21980775
27	ADRBK2	1.21458343
28	EPHA4	1.21063303
29	CSNK1G2	1.18120197
30	CLK1	1.15373050
31	PLK4	1.14481777
32	CSNK1G3	1.12958591
33	FGFR2	1.09335798
34	STK39	1.04494090
35	EPHA3	1.04359595
36	MKNK1	0.95813118
37	CAMKK2	0.95796957
38	ERBB3	0.95256407
39	BRSK2	0.94933232
40	MUSK	0.94619750
41	EIF2AK3	0.93633566
42	PRKCG	0.91982471
43	NTRK2	0.91433942
44	WNK4	0.86840441
45	MINK1	0.86435047
46	DYRK1A	0.84144190
47	SGK2	0.83458186
48	PRKCE	0.76806298
49	TRIM28	0.76293791
50	SGK494	0.73833608
51	SGK223	0.73833608
52	OXSR1	0.71559000
53	YES1	0.70838786
54	EPHB2	0.70725713
55	PLK2	0.70295508
56	MAP2K4	0.69201187
57	PLK3	0.68961038
58	INSRR	0.66248963
59	IRAK4	0.63236356
60	PKN1	0.63093321
61	STK16	0.62412017
62	TSSK6	0.61155988
63	NLK	0.60805834
64	SGK1	0.58702403
65	UHMK1	0.58499875
66	ERBB4	0.57659775
67	CSNK1D	0.57220097
68	PRKCZ	0.56801147
69	CAMK2A	0.54836182
70	VRK1	0.52073980
71	CSNK1A1L	0.49104064
72	PRKACA	0.47562469
73	PHKG1	0.46997356
74	PHKG2	0.46997356
75	PAK6	0.46927108
76	PTK2B	0.46582582
77	CSNK1A1	0.46125999
78	TGFBR1	0.46115759
79	TTK	0.45213026
80	AKT3	0.44787573
81	PLK1	0.44416319
82	MST4	0.44048438
83	CDC7	0.43684391
84	PRKACB	0.43317507
85	STK38L	0.42595076
86	BUB1	0.42416296
87	CDK5	0.41770927
88	ADRBK1	0.40046573
89	GSK3A	0.39533539
90	TAF1	0.38969339
91	PBK	0.38380391
92	SRPK1	0.38152248
93	BRD4	0.37622268
94	PRKG1	0.37562908
95	FER	0.36535304
96	ATM	0.35954993
97	ROCK1	0.35596121
98	MAP3K12	0.35545043
99	CSNK1E	0.34637334
100	FGFR1	0.33712125

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.22992997
2	Nicotine addiction_Homo sapiens_hsa05033	3.20966275
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.11296933
4	Butanoate metabolism_Homo sapiens_hsa00650	2.62015367
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.45414095
6	Steroid biosynthesis_Homo sapiens_hsa00100	1.97161654
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96542729
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.96347116
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96071963
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.95485530
11	Glutamatergic synapse_Homo sapiens_hsa04724	1.84673103
12	Circadian rhythm_Homo sapiens_hsa04710	1.69957136
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64587715
14	Basal transcription factors_Homo sapiens_hsa03022	1.60998503
15	GABAergic synapse_Homo sapiens_hsa04727	1.56028711
16	Taste transduction_Homo sapiens_hsa04742	1.55346643
17	Circadian entrainment_Homo sapiens_hsa04713	1.54673690
18	Propanoate metabolism_Homo sapiens_hsa00640	1.51787619
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51661705
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50214368
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49370164
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45863136
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.45574981
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42759646
25	Amphetamine addiction_Homo sapiens_hsa05031	1.42647120
26	Parkinsons disease_Homo sapiens_hsa05012	1.42337288
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.41422890
28	Morphine addiction_Homo sapiens_hsa05032	1.39617234
29	Cocaine addiction_Homo sapiens_hsa05030	1.38513776
30	Huntingtons disease_Homo sapiens_hsa05016	1.34174774
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.31597369
32	Serotonergic synapse_Homo sapiens_hsa04726	1.30761512
33	Phototransduction_Homo sapiens_hsa04744	1.30065894
34	ABC transporters_Homo sapiens_hsa02010	1.29370211
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.26399023
36	Mismatch repair_Homo sapiens_hsa03430	1.24187894
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.23483270
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18195318
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.17854871
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.14647338
41	Fatty acid degradation_Homo sapiens_hsa00071	1.13043362
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12351802
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12156918
44	Olfactory transduction_Homo sapiens_hsa04740	1.09414556
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06748945
46	Protein export_Homo sapiens_hsa03060	1.04098715
47	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03613413
48	Alzheimers disease_Homo sapiens_hsa05010	1.00615865
49	RNA degradation_Homo sapiens_hsa03018	1.00403243
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99023685
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.95422601
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94248166
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94225444
54	Insulin secretion_Homo sapiens_hsa04911	0.93169745
55	One carbon pool by folate_Homo sapiens_hsa00670	0.90106919
56	Histidine metabolism_Homo sapiens_hsa00340	0.89172596
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83094928
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83037620
59	Caffeine metabolism_Homo sapiens_hsa00232	0.82994385
60	Salivary secretion_Homo sapiens_hsa04970	0.79833081
61	Axon guidance_Homo sapiens_hsa04360	0.79627366
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79200256
63	Proteasome_Homo sapiens_hsa03050	0.76851847
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75071836
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.74917998
66	RNA polymerase_Homo sapiens_hsa03020	0.74900908
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74451311
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73606589
69	Peroxisome_Homo sapiens_hsa04146	0.71225632
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.70154442
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69818859
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68042979
73	Mineral absorption_Homo sapiens_hsa04978	0.66964436
74	Oocyte meiosis_Homo sapiens_hsa04114	0.66519587
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65704756
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.65507035
77	Long-term depression_Homo sapiens_hsa04730	0.65126864
78	Homologous recombination_Homo sapiens_hsa03440	0.63386865
79	Retinol metabolism_Homo sapiens_hsa00830	0.63029539
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61596994
81	Fatty acid elongation_Homo sapiens_hsa00062	0.60817906
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60121689
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.57601625
84	Glutathione metabolism_Homo sapiens_hsa00480	0.57551384
85	Lysine degradation_Homo sapiens_hsa00310	0.54413187
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53895516
87	Cholinergic synapse_Homo sapiens_hsa04725	0.52845536
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.50972743
89	Metabolic pathways_Homo sapiens_hsa01100	0.50585227
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49974213
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47200966
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47055811
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46169516
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46134629
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45688478
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.44541664
97	RNA transport_Homo sapiens_hsa03013	0.42004626
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41030361
99	Gastric acid secretion_Homo sapiens_hsa04971	0.40531036
100	Renin secretion_Homo sapiens_hsa04924	0.39468664

HDAC1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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