HDAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.06181210
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.31642750
3negative regulation of RNA splicing (GO:0033119)4.09409023
4mitotic sister chromatid cohesion (GO:0007064)3.81519209
5microtubule depolymerization (GO:0007019)3.81146669
6protein localization to kinetochore (GO:0034501)3.72913071
7negative regulation of mRNA processing (GO:0050686)3.70493129
8DNA double-strand break processing (GO:0000729)3.70104968
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56056522
10pyrimidine nucleobase catabolic process (GO:0006208)3.55716153
11DNA strand elongation involved in DNA replication (GO:0006271)3.52003143
12DNA replication-dependent nucleosome assembly (GO:0006335)3.51975294
13DNA replication-dependent nucleosome organization (GO:0034723)3.51975294
14nuclear pore organization (GO:0006999)3.51961505
15DNA damage response, detection of DNA damage (GO:0042769)3.44783886
16dosage compensation (GO:0007549)3.43784120
17peptidyl-arginine omega-N-methylation (GO:0035247)3.41776359
18nuclear pore complex assembly (GO:0051292)3.35703414
19formation of translation preinitiation complex (GO:0001731)3.35349091
20DNA replication initiation (GO:0006270)3.35320509
21peptidyl-arginine methylation (GO:0018216)3.33462830
22peptidyl-arginine N-methylation (GO:0035246)3.33462830
23DNA strand elongation (GO:0022616)3.31912367
24mitotic nuclear envelope disassembly (GO:0007077)3.31353605
25regulation of RNA export from nucleus (GO:0046831)3.31018358
26negative regulation of mRNA metabolic process (GO:1903312)3.22498344
27mitotic chromosome condensation (GO:0007076)3.22087337
28nuclear envelope disassembly (GO:0051081)3.21025942
29membrane disassembly (GO:0030397)3.21025942
30regulation of sister chromatid cohesion (GO:0007063)3.20151588
31DNA topological change (GO:0006265)3.17734686
32establishment of integrated proviral latency (GO:0075713)3.16897954
33viral transcription (GO:0019083)3.16390666
34translational termination (GO:0006415)3.16306080
35DNA ligation (GO:0006266)3.15060179
36DNA replication-independent nucleosome assembly (GO:0006336)3.14703133
37DNA replication-independent nucleosome organization (GO:0034724)3.14703133
38protein localization to chromosome, centromeric region (GO:0071459)3.11167563
39mRNA splicing, via spliceosome (GO:0000398)3.09709436
40RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.09709436
41sister chromatid segregation (GO:0000819)3.08803792
42kinetochore organization (GO:0051383)3.06768731
43pre-miRNA processing (GO:0031054)3.06480218
44DNA duplex unwinding (GO:0032508)3.05507239
45RNA splicing, via transesterification reactions (GO:0000375)3.05244701
46DNA geometric change (GO:0032392)3.03804513
47telomere maintenance via semi-conservative replication (GO:0032201)3.01746747
48translesion synthesis (GO:0019985)3.01274419
49negative regulation of DNA recombination (GO:0045910)3.01144327
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00277642
51resolution of meiotic recombination intermediates (GO:0000712)3.00125307
52maturation of SSU-rRNA (GO:0030490)2.99703171
53alternative mRNA splicing, via spliceosome (GO:0000380)2.99635033
54ribosomal small subunit assembly (GO:0000028)2.96747248
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95744251
56somatic hypermutation of immunoglobulin genes (GO:0016446)2.95744251
57histone arginine methylation (GO:0034969)2.95204755
58establishment of viral latency (GO:0019043)2.94850346
59spindle assembly checkpoint (GO:0071173)2.94629814
60termination of RNA polymerase II transcription (GO:0006369)2.94514028
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93488093
62mitotic spindle assembly checkpoint (GO:0007094)2.93451918
63mitotic recombination (GO:0006312)2.93256582
64translational initiation (GO:0006413)2.91968572
65chromatin remodeling at centromere (GO:0031055)2.88534151
66negative regulation of chromosome segregation (GO:0051985)2.87151872
67mitotic metaphase plate congression (GO:0007080)2.86455712
68translational elongation (GO:0006414)2.86002312
69negative regulation of histone methylation (GO:0031061)2.85793665
70negative regulation of mitotic sister chromatid separation (GO:2000816)2.85612175
71negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85612175
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85612175
73negative regulation of sister chromatid segregation (GO:0033046)2.85612175
74CENP-A containing nucleosome assembly (GO:0034080)2.84237019
75chromatin assembly or disassembly (GO:0006333)2.83612947
76mitotic spindle checkpoint (GO:0071174)2.82498851
77nucleosome disassembly (GO:0006337)2.82338942
78protein-DNA complex disassembly (GO:0032986)2.82338942
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82233050
80regulation of mitotic spindle checkpoint (GO:1903504)2.82233050
81peptidyl-lysine dimethylation (GO:0018027)2.80943419
82purine nucleobase biosynthetic process (GO:0009113)2.80333205
83IMP biosynthetic process (GO:0006188)2.80040076
84* ATP-dependent chromatin remodeling (GO:0043044)2.78993189
85kinetochore assembly (GO:0051382)2.78623046
86postreplication repair (GO:0006301)2.77655764
87regulation of chromosome segregation (GO:0051983)2.76913221
88spindle checkpoint (GO:0031577)2.76113226
89regulation of histone H3-K9 methylation (GO:0051570)2.75979792
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75951304
91non-recombinational repair (GO:0000726)2.75295877
92double-strand break repair via nonhomologous end joining (GO:0006303)2.75295877
93protein localization to chromosome (GO:0034502)2.73416404
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73364608
95regulation of translational fidelity (GO:0006450)2.73058335
96L-serine metabolic process (GO:0006563)2.70892742
97histone H2A acetylation (GO:0043968)2.70623312
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.70571001
99RNA export from nucleus (GO:0006405)2.70177427
100attachment of spindle microtubules to kinetochore (GO:0008608)2.69931526
101mRNA splice site selection (GO:0006376)2.69365692
102spliceosomal snRNP assembly (GO:0000387)2.69024868
103presynaptic membrane assembly (GO:0097105)2.67838414
104telomere maintenance via recombination (GO:0000722)2.67805723
105regulation of DNA damage checkpoint (GO:2000001)2.67396585
106mitotic sister chromatid segregation (GO:0000070)2.67027654
107regulation of centriole replication (GO:0046599)2.66603621
108nucleobase catabolic process (GO:0046113)2.66589187
109cullin deneddylation (GO:0010388)2.66552099
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66177743
111viral mRNA export from host cell nucleus (GO:0046784)2.65832551
112paraxial mesoderm development (GO:0048339)2.65775190
113metaphase plate congression (GO:0051310)2.65326934
114regulation of development, heterochronic (GO:0040034)2.65191461
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.64968136
116regulation of helicase activity (GO:0051095)2.64950201
117DNA replication checkpoint (GO:0000076)2.64401070
118microtubule polymerization or depolymerization (GO:0031109)2.64347570
119histone exchange (GO:0043486)2.64240458
120regulation of mitotic sister chromatid separation (GO:0010965)2.63616845
121regulation of mitotic sister chromatid segregation (GO:0033047)2.63616845
122regulation of sister chromatid segregation (GO:0033045)2.63616845
123protein complex disassembly (GO:0043241)2.63369163
124heterochromatin organization (GO:0070828)2.62271575
125mRNA transport (GO:0051028)2.62075959
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.60472218
127replication fork processing (GO:0031297)2.58708959
128intraciliary transport (GO:0042073)2.57631028
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.56382572
130mitotic spindle organization (GO:0007052)2.52944900
131regulation of mRNA splicing, via spliceosome (GO:0048024)2.52649106
132DNA catabolic process, exonucleolytic (GO:0000738)2.50522107
133protein neddylation (GO:0045116)2.49569942
134regulation of double-strand break repair via homologous recombination (GO:0010569)2.48685070
135nucleobase biosynthetic process (GO:0046112)2.48154806
136regulation of DNA endoreduplication (GO:0032875)2.47448217
137IMP metabolic process (GO:0046040)2.46738845
138proteasome assembly (GO:0043248)2.46437913
139regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.44849852
140histone mRNA metabolic process (GO:0008334)2.44381814
141protein deneddylation (GO:0000338)2.41932235
142synapsis (GO:0007129)2.41452740
143organelle disassembly (GO:1903008)2.40385763
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.38116025
145presynaptic membrane organization (GO:0097090)2.37946471
146olfactory bulb development (GO:0021772)2.36309293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.90952172
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.65988406
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.26137608
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90122988
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.54848742
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34064483
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03412480
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98583393
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63239470
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60747073
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52589050
12IGF1R_20145208_ChIP-Seq_DFB_Human2.48425339
13XRN2_22483619_ChIP-Seq_HELA_Human2.44333415
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.43993324
15ZNF274_21170338_ChIP-Seq_K562_Hela2.40629071
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32930484
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28099347
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.28046904
19* EGR1_19374776_ChIP-ChIP_THP-1_Human2.25886354
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20470772
21MYC_22102868_ChIP-Seq_BL_Human2.13528769
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11511463
23AR_21909140_ChIP-Seq_LNCAP_Human2.08423023
24EWS_26573619_Chip-Seq_HEK293_Human2.08251065
25* FUS_26573619_Chip-Seq_HEK293_Human2.00544134
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98884671
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98514931
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97082557
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.94379088
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93669462
31CIITA_25753668_ChIP-Seq_RAJI_Human1.88716095
32* TTF2_22483619_ChIP-Seq_HELA_Human1.88269297
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.87768179
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84411751
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.82266181
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.80988691
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80905695
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80385577
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80039189
40TAF15_26573619_Chip-Seq_HEK293_Human1.78508394
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78141650
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73342710
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73023119
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.71554653
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69403387
46* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68282923
47MYC_18940864_ChIP-ChIP_HL60_Human1.67846442
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64869049
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61894437
50VDR_22108803_ChIP-Seq_LS180_Human1.61511573
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58572700
52* VDR_23849224_ChIP-Seq_CD4+_Human1.57952324
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55418187
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55179219
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55005968
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54194187
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54059113
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54005877
59* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52338192
60GABP_19822575_ChIP-Seq_HepG2_Human1.49842255
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49356814
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46291411
63IRF1_19129219_ChIP-ChIP_H3396_Human1.45439761
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45120362
65* DCP1A_22483619_ChIP-Seq_HELA_Human1.42372780
66P300_19829295_ChIP-Seq_ESCs_Human1.41768144
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41375759
68EZH2_22144423_ChIP-Seq_EOC_Human1.39921779
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39731713
70* FOXP3_21729870_ChIP-Seq_TREG_Human1.38510205
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37310959
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37102654
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35801313
74* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35233326
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32626752
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32402157
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.31708404
78ELK1_19687146_ChIP-ChIP_HELA_Human1.31653666
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30761882
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29952425
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29774145
82* RNF2_27304074_Chip-Seq_NSC_Mouse1.29356997
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.28835121
84KDM5A_27292631_Chip-Seq_BREAST_Human1.28633228
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27457074
86GBX2_23144817_ChIP-Seq_PC3_Human1.24871423
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23237329
88* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21706138
89* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19273211
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19139136
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18438521
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18152779
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17515821
94* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16499980
95* SOX2_16153702_ChIP-ChIP_HESCs_Human1.13948379
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13755987
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.13354408
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12354575
99CHD1_26751641_Chip-Seq_LNCaP_Human1.11905672
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11771959
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10550907
102ZNF263_19887448_ChIP-Seq_K562_Human1.10147497
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10129790
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09884785
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.09717762
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08646806
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07535347
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07485908
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04586341
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04329612
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03859492
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02954698
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02247382
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00787758
115VDR_21846776_ChIP-Seq_THP-1_Human1.00698083
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00508872
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.99326579
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98630629
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98276078
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97156809
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97126436
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96202525
123* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95318987
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95136236
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94935351
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94524474
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94428103
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94033822
129* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93696452
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93446183
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93124610
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89814547
133* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89681479
134* SOX9_26525672_Chip-Seq_HEART_Mouse0.89575459
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88890210
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.88590724
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88575623
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87341108
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87341108
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87341108
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86886307
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86420467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.06564902
2MP0003693_abnormal_embryo_hatching3.01182751
3MP0003123_paternal_imprinting2.95782456
4MP0010094_abnormal_chromosome_stability2.89326595
5MP0004957_abnormal_blastocyst_morpholog2.88309576
6MP0006292_abnormal_olfactory_placode2.81630285
7MP0010030_abnormal_orbit_morphology2.66286615
8MP0003077_abnormal_cell_cycle2.54442630
9MP0003111_abnormal_nucleus_morphology2.54000706
10MP0001529_abnormal_vocalization2.46339674
11MP0003121_genomic_imprinting2.35314142
12MP0001188_hyperpigmentation2.31178908
13MP0008057_abnormal_DNA_replication2.29714183
14MP0003880_abnormal_central_pattern2.16241082
15MP0008007_abnormal_cellular_replicative2.12316201
16MP0010352_gastrointestinal_tract_polyps2.11762139
17MP0009053_abnormal_anal_canal1.98982786
18MP0008932_abnormal_embryonic_tissue1.88205344
19MP0001730_embryonic_growth_arrest1.84628822
20MP0002084_abnormal_developmental_patter1.84626085
21MP0008058_abnormal_DNA_repair1.83499854
22MP0008789_abnormal_olfactory_epithelium1.81684231
23MP0000350_abnormal_cell_proliferation1.81029275
24MP0001293_anophthalmia1.80449526
25MP0003890_abnormal_embryonic-extraembry1.78737632
26MP0003122_maternal_imprinting1.76701099
27MP0008877_abnormal_DNA_methylation1.75263982
28MP0004197_abnormal_fetal_growth/weight/1.71880881
29MP0002085_abnormal_embryonic_tissue1.71570282
30MP0006276_abnormal_autonomic_nervous1.65538599
31MP0003119_abnormal_digestive_system1.64478519
32MP0005076_abnormal_cell_differentiation1.61012825
33MP0002938_white_spotting1.59447626
34MP0003937_abnormal_limbs/digits/tail_de1.57417599
35MP0001697_abnormal_embryo_size1.54739382
36MP0003942_abnormal_urinary_system1.53211879
37MP0000049_abnormal_middle_ear1.49685458
38MP0003385_abnormal_body_wall1.48505348
39MP0005187_abnormal_penis_morphology1.46261204
40MP0001672_abnormal_embryogenesis/_devel1.44094060
41MP0005380_embryogenesis_phenotype1.44094060
42MP0003861_abnormal_nervous_system1.43528219
43MP0005394_taste/olfaction_phenotype1.42854987
44MP0005499_abnormal_olfactory_system1.42854987
45MP0003787_abnormal_imprinting1.40871156
46MP0003315_abnormal_perineum_morphology1.40661345
47MP0008995_early_reproductive_senescence1.38716005
48MP0000566_synostosis1.38315296
49MP0003718_maternal_effect1.36627968
50MP0006054_spinal_hemorrhage1.34767555
51MP0002653_abnormal_ependyma_morphology1.34358624
52* MP0002080_prenatal_lethality1.33699014
53MP0002932_abnormal_joint_morphology1.32771094
54MP0000428_abnormal_craniofacial_morphol1.32665467
55MP0003984_embryonic_growth_retardation1.30829119
56MP0002088_abnormal_embryonic_growth/wei1.29969546
57MP0002282_abnormal_trachea_morphology1.29850366
58MP0000534_abnormal_ureter_morphology1.28576757
59MP0003941_abnormal_skin_development1.27633769
60MP0000569_abnormal_digit_pigmentation1.26194679
61MP0001849_ear_inflammation1.25393167
62MP0003935_abnormal_craniofacial_develop1.23544756
63MP0003136_yellow_coat_color1.23371351
64MP0003755_abnormal_palate_morphology1.23317370
65* MP0003567_abnormal_fetal_cardiomyocyte1.23209106
66MP0002086_abnormal_extraembryonic_tissu1.22874167
67MP0005623_abnormal_meninges_morphology1.22291617
68MP0003283_abnormal_digestive_organ1.21350720
69MP0003705_abnormal_hypodermis_morpholog1.21320117
70MP0000778_abnormal_nervous_system1.21008383
71MP0001984_abnormal_olfaction1.20003310
72MP0002822_catalepsy1.19169217
73MP0002233_abnormal_nose_morphology1.17389929
74MP0005253_abnormal_eye_physiology1.17206250
75MP0003115_abnormal_respiratory_system1.16817571
76MP0002092_abnormal_eye_morphology1.16539984
77MP0009697_abnormal_copulation1.16442700
78MP0002102_abnormal_ear_morphology1.16301107
79MP0004270_analgesia1.14520697
80MP0002116_abnormal_craniofacial_bone1.13325715
81MP0000955_abnormal_spinal_cord1.12512324
82MP0001286_abnormal_eye_development1.11581950
83MP0002396_abnormal_hematopoietic_system1.11137491
84MP0000733_abnormal_muscle_development1.10971122
85MP0000647_abnormal_sebaceous_gland1.08799167
86MP0002751_abnormal_autonomic_nervous1.07772994
87MP0005391_vision/eye_phenotype1.06247339
88MP0002249_abnormal_larynx_morphology1.05433995
89MP0002736_abnormal_nociception_after1.03117329
90MP0004811_abnormal_neuron_physiology1.02585598
91MP0002697_abnormal_eye_size1.02483241
92* MP0002114_abnormal_axial_skeleton1.02345021
93MP0004133_heterotaxia1.01915432
94MP0004233_abnormal_muscle_weight1.00916758
95MP0002111_abnormal_tail_morphology1.00103667
96* MP0002081_perinatal_lethality1.00075583
97* MP0009250_abnormal_appendicular_skeleto0.99672294
98MP0002752_abnormal_somatic_nervous0.99264078
99MP0000432_abnormal_head_morphology0.99239449
100MP0006035_abnormal_mitochondrial_morpho0.95433795
101MP0000631_abnormal_neuroendocrine_gland0.94931183
102MP0010234_abnormal_vibrissa_follicle0.93022268
103MP0001929_abnormal_gametogenesis0.92981574
104MP0001485_abnormal_pinna_reflex0.92414637
105MP0004808_abnormal_hematopoietic_stem0.91375495
106MP0000516_abnormal_urinary_system0.90306212
107MP0005367_renal/urinary_system_phenotyp0.90306212
108MP0002234_abnormal_pharynx_morphology0.88666905
109MP0010307_abnormal_tumor_latency0.87735961
110MP0009672_abnormal_birth_weight0.87018730
111MP0002877_abnormal_melanocyte_morpholog0.86923244
112* MP0000653_abnormal_sex_gland0.86445266
113MP0003698_abnormal_male_reproductive0.86248213
114* MP0009703_decreased_birth_body0.85828570
115* MP0002210_abnormal_sex_determination0.85628220
116MP0002160_abnormal_reproductive_system0.85494975
117MP0005645_abnormal_hypothalamus_physiol0.85456371
118MP0005423_abnormal_somatic_nervous0.85434550
119MP0006072_abnormal_retinal_apoptosis0.85196460
120* MP0002882_abnormal_neuron_morphology0.84201403
121MP0002734_abnormal_mechanical_nocicepti0.84102411
122MP0000313_abnormal_cell_death0.84041145
123MP0003786_premature_aging0.83300297
124MP0009046_muscle_twitch0.83123269
125MP0002184_abnormal_innervation0.82933649
126MP0001177_atelectasis0.81964921
127MP0005551_abnormal_eye_electrophysiolog0.78784337
128MP0001348_abnormal_lacrimal_gland0.78717228
129MP0001486_abnormal_startle_reflex0.78715188
130* MP0000490_abnormal_crypts_of0.78115872
131MP0001299_abnormal_eye_distance/0.77331685
132MP0002177_abnormal_outer_ear0.77314887
133MP0003938_abnormal_ear_development0.76943413
134* MP0001145_abnormal_male_reproductive0.76695418
135* MP0002152_abnormal_brain_morphology0.75416846

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.65440282
2Cortical dysplasia (HP:0002539)3.46359129
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.40331641
4Short 4th metacarpal (HP:0010044)3.40331641
5Renal duplication (HP:0000075)3.24612171
6Ependymoma (HP:0002888)3.12084335
7Increased nuchal translucency (HP:0010880)3.08772992
8Volvulus (HP:0002580)2.93565352
9Hyperacusis (HP:0010780)2.85228116
10Medulloblastoma (HP:0002885)2.81730616
11Pelvic girdle muscle weakness (HP:0003749)2.77477712
12Selective tooth agenesis (HP:0001592)2.66774628
13Abnormal lung lobation (HP:0002101)2.64195706
14Abnormality of the astrocytes (HP:0100707)2.63527054
15Astrocytoma (HP:0009592)2.63527054
16Abnormality of the 4th metacarpal (HP:0010012)2.62700580
17Shoulder girdle muscle weakness (HP:0003547)2.57952467
18Proximal placement of thumb (HP:0009623)2.55800500
19Meckel diverticulum (HP:0002245)2.52206490
20Abnormality of the ileum (HP:0001549)2.46011018
21Chromsome breakage (HP:0040012)2.42893599
22Hyperglycinemia (HP:0002154)2.42518917
23Abnormality of the hip-girdle musculature (HP:0001445)2.41437408
24Abnormality of the musculature of the pelvis (HP:0001469)2.41437408
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40938916
26Nephrogenic diabetes insipidus (HP:0009806)2.40249001
27Atresia of the external auditory canal (HP:0000413)2.38471685
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.36421339
29Deviation of the thumb (HP:0009603)2.35726324
30Septo-optic dysplasia (HP:0100842)2.35643054
31Overriding aorta (HP:0002623)2.35443519
32Intestinal atresia (HP:0011100)2.35372058
33Gait imbalance (HP:0002141)2.32881748
34Renovascular hypertension (HP:0100817)2.32219958
35Abnormal number of incisors (HP:0011064)2.31327472
36Reticulocytopenia (HP:0001896)2.29348342
37Congenital primary aphakia (HP:0007707)2.29005987
38Abnormality of cells of the erythroid lineage (HP:0012130)2.28879100
39Lissencephaly (HP:0001339)2.27960542
40Facial hemangioma (HP:0000329)2.27557067
41Medial flaring of the eyebrow (HP:0010747)2.26450473
42Abnormality of chromosome stability (HP:0003220)2.23627096
43Elfin facies (HP:0004428)2.23427906
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.23417357
45Bowel diverticulosis (HP:0005222)2.19065167
46Pancreatic fibrosis (HP:0100732)2.18940205
47Glioma (HP:0009733)2.17232446
48Vaginal atresia (HP:0000148)2.16796109
49Patellar aplasia (HP:0006443)2.16182294
50Genital tract atresia (HP:0001827)2.15262079
51Insomnia (HP:0100785)2.14558606
52True hermaphroditism (HP:0010459)2.11905045
53Aplasia/Hypoplasia of the patella (HP:0006498)2.10527619
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.05887589
55Abnormality of the anterior horn cell (HP:0006802)2.05386220
56Degeneration of anterior horn cells (HP:0002398)2.05386220
57Abnormal number of erythroid precursors (HP:0012131)2.04119089
58Sacral dimple (HP:0000960)2.03650792
59Pancreatic cysts (HP:0001737)2.03483859
60Supernumerary spleens (HP:0009799)2.01210210
61Ankle contracture (HP:0006466)1.99009575
62Abnormality of the labia minora (HP:0012880)1.97995676
63Bifid tongue (HP:0010297)1.97749586
64Hepatoblastoma (HP:0002884)1.97503018
65Abnormality of midbrain morphology (HP:0002418)1.97343914
66Molar tooth sign on MRI (HP:0002419)1.97343914
67Flat cornea (HP:0007720)1.97319960
68Methylmalonic acidemia (HP:0002912)1.97088097
69Neoplasm of the oral cavity (HP:0100649)1.95546685
70Pointed chin (HP:0000307)1.94832370
71Preaxial hand polydactyly (HP:0001177)1.94751728
72Shallow orbits (HP:0000586)1.94096448
73Abnormality of the diencephalon (HP:0010662)1.93100900
74Megalocornea (HP:0000485)1.92901336
75High anterior hairline (HP:0009890)1.92614077
76Nephronophthisis (HP:0000090)1.92214969
77Duodenal stenosis (HP:0100867)1.91507064
78Small intestinal stenosis (HP:0012848)1.91507064
79Triphalangeal thumb (HP:0001199)1.91356082
80Obsessive-compulsive behavior (HP:0000722)1.91059313
81Drooling (HP:0002307)1.90842207
82Sclerocornea (HP:0000647)1.90607874
83Amyotrophic lateral sclerosis (HP:0007354)1.90421753
84Abnormality of the duodenum (HP:0002246)1.88217204
85Acute necrotizing encephalopathy (HP:0006965)1.88017471
86Sloping forehead (HP:0000340)1.87909885
87Broad palm (HP:0001169)1.87035958
88Optic nerve hypoplasia (HP:0000609)1.86354377
89Ankyloglossia (HP:0010296)1.86092551
90Basal cell carcinoma (HP:0002671)1.85406375
91Abnormality of abdominal situs (HP:0011620)1.83996348
92Abdominal situs inversus (HP:0003363)1.83996348
93Micropenis (HP:0000054)1.82853902
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82739768
95Angiofibromas (HP:0010615)1.82173289
96Adenoma sebaceum (HP:0009720)1.82173289
97Intestinal polyp (HP:0005266)1.81781692
98Missing ribs (HP:0000921)1.81179071
99Intestinal polyposis (HP:0200008)1.80863871
100Wrist flexion contracture (HP:0001239)1.80572901
101Nephroblastoma (Wilms tumor) (HP:0002667)1.80129560
102Broad thumb (HP:0011304)1.79806970
103Rhabdomyosarcoma (HP:0002859)1.79634714
104Absent radius (HP:0003974)1.78319826
105Hallux valgus (HP:0001822)1.78071467
106Broad foot (HP:0001769)1.78062472
107Deviation of the hallux (HP:0010051)1.77764227
108Embryonal renal neoplasm (HP:0011794)1.77619257
109Acute encephalopathy (HP:0006846)1.77561006
110Abnormality of the preputium (HP:0100587)1.77287381
111Oligodactyly (hands) (HP:0001180)1.77275530
112Anophthalmia (HP:0000528)1.76633486
113Broad alveolar ridges (HP:0000187)1.75757199
114Impaired vibration sensation in the lower limbs (HP:0002166)1.75711978
115Dandy-Walker malformation (HP:0001305)1.75633867
116Neoplasm of the pancreas (HP:0002894)1.75481836
117Neoplasm of striated muscle (HP:0009728)1.74894226
118Anencephaly (HP:0002323)1.73890548
119Renal hypoplasia (HP:0000089)1.73716039
120Abnormal hair whorl (HP:0010721)1.73349396
121Absent forearm bone (HP:0003953)1.73294542
122Aplasia involving forearm bones (HP:0009822)1.73294542
123Poor coordination (HP:0002370)1.73068753
124Protrusio acetabuli (HP:0003179)1.73001138
125Broad phalanges of the hand (HP:0009768)1.72752261
126Birth length less than 3rd percentile (HP:0003561)1.72683992
127Hypoplasia of the pons (HP:0012110)1.72574754
128Rectal prolapse (HP:0002035)1.72042242
129Overlapping toe (HP:0001845)1.71972169
130Absent septum pellucidum (HP:0001331)1.71900460
131Specific learning disability (HP:0001328)1.71777336
132Horseshoe kidney (HP:0000085)1.71363015
133Gastrointestinal atresia (HP:0002589)1.71314544
134Postaxial foot polydactyly (HP:0001830)1.70845378
135Trigonocephaly (HP:0000243)1.70040111
136Decreased testicular size (HP:0008734)1.69881264
137Abnormality of the metopic suture (HP:0005556)1.69699594
138Bladder diverticulum (HP:0000015)1.69484419
139Hypoplastic pelvis (HP:0008839)1.68953772
140Heterotopia (HP:0002282)1.68902979
141Short middle phalanx of the 5th finger (HP:0004220)1.68686963
142Biliary tract neoplasm (HP:0100574)1.68519125
143Bilateral microphthalmos (HP:0007633)1.68393276
144Rib fusion (HP:0000902)1.67828205
145Ectopic kidney (HP:0000086)1.66984012
146Retinal dysplasia (HP:0007973)1.66529395
147Postaxial hand polydactyly (HP:0001162)1.66482372
148Small hand (HP:0200055)1.66124651
149Hemivertebrae (HP:0002937)1.65610735
150Short 5th finger (HP:0009237)1.65603991
151Abnormality of the septum pellucidum (HP:0007375)1.65543429
152Abnormality of serine family amino acid metabolism (HP:0010894)1.65408442
153Abnormality of glycine metabolism (HP:0010895)1.65408442
154Narrow forehead (HP:0000341)1.65329682
155Hypoplastic female external genitalia (HP:0012815)1.65324564
156Gastrointestinal carcinoma (HP:0002672)1.65231279
157Malignant gastrointestinal tract tumors (HP:0006749)1.65231279
158Stenosis of the external auditory canal (HP:0000402)1.64760608
159Esophageal atresia (HP:0002032)1.63791531
160Fibrous tissue neoplasm (HP:0012316)1.63655024
161Ovarian neoplasm (HP:0100615)1.63345712
162Scrotal hypoplasia (HP:0000046)1.63221333
163Increased hepatocellular lipid droplets (HP:0006565)1.62741932
164Excessive salivation (HP:0003781)1.62225754
165Broad finger (HP:0001500)1.62158946
166Neoplasm of the colon (HP:0100273)1.61560429
167Buphthalmos (HP:0000557)1.61305241
168Glossoptosis (HP:0000162)1.59674863
169Fibroma (HP:0010614)1.58970457
170Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.57935477
171Abnormality of oral frenula (HP:0000190)1.54536596
172Neoplasm of the small intestine (HP:0100833)1.53803789
173Calcaneovalgus deformity (HP:0001848)1.53785351
174Adducted thumb (HP:0001181)1.53516277
175Subacute progressive viral hepatitis (HP:0006572)1.53147233
176Abnormality of the calcaneus (HP:0008364)1.52159171
177Patellar dislocation (HP:0002999)1.51598729
178Broad phalanx (HP:0006009)1.51160385
179Broad distal phalanx of finger (HP:0009836)1.50432389
180Pendular nystagmus (HP:0012043)1.50279601
181Short philtrum (HP:0000322)1.50229740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.60884749
2TRIM282.94518322
3WNK32.86510917
4DYRK32.77258225
5WEE12.71290009
6CASK2.59904001
7NEK12.48635450
8ACVR1B2.46337482
9EEF2K2.44622554
10NEK22.44304724
11SRPK12.43253617
12MKNK12.42386059
13MAP4K22.33738752
14MAP3K102.32004214
15BUB12.31199355
16ERBB32.30548065
17SCYL22.24992947
18PLK42.06901072
19MAP2K72.02387125
20MARK12.00291367
21PASK1.90852605
22TGFBR11.87087407
23KSR11.76850489
24CDK121.75191784
25STK38L1.65232663
26PKN21.62494831
27DYRK21.62330332
28RPS6KB21.57503972
29MKNK21.55620260
30TNIK1.55185197
31ZAK1.54476154
32PBK1.46014273
33ATR1.45244901
34VRK21.43242410
35TAF11.42622181
36PLK11.38102430
37PLK31.34887457
38TRIB31.34523074
39CDK71.32884759
40PAK41.32178006
41TTK1.31683836
42CHEK21.25828737
43RPS6KA41.23209142
44AURKB1.22160016
45PDGFRA1.20384999
46EPHA41.19910129
47NUAK11.19036513
48TSSK61.16891031
49VRK11.15486710
50ILK1.15123340
51BRD41.14943532
52TYRO31.14605901
53BMPR1B1.14183056
54UHMK11.11748943
55LIMK11.10536793
56EPHB21.10111449
57CHEK11.08801096
58CDK61.05396687
59AURKA1.04195250
60BRSK21.01781026
61PNCK0.98941946
62TESK20.98408030
63MAPK130.97508515
64DYRK1B0.96325288
65DDR20.92211244
66CDK40.91598637
67CDK20.88774522
68BRSK10.88486651
69PLK20.86909692
70CSNK1G30.81807588
71FGFR10.81176888
72LATS20.81073327
73ALK0.79900561
74ATM0.79162966
75TESK10.76680020
76CDK80.76302400
77LRRK20.76252660
78CSNK1A1L0.75722761
79CDK10.72967099
80PAK20.72687476
81LATS10.71476664
82MAP3K80.70368883
83FGFR20.68838678
84CSNK1G20.68513584
85ERBB20.68065091
86MTOR0.66588117
87BCKDK0.65320619
88MINK10.63455607
89MAP2K40.61708976
90MAP3K60.61052028
91DAPK10.61026652
92BCR0.60366219
93PRKCG0.59107108
94CDK140.58541227
95CCNB10.58303510
96* CSNK1E0.56826158
97CDK180.55781513
98CSNK1G10.55645716
99ICK0.54870631
100OXSR10.53926593
101EIF2AK10.53815420
102NTRK20.53449103
103NME10.52434560
104PAK30.52157121
105CDK11A0.51521825
106CDK150.51278280
107CDK30.50869351
108AKT20.49220689
109MAPK90.47615157
110* CSNK2A20.47366075
111STK160.47364765
112RAF10.46305689
113PRKDC0.45943942
114TLK10.45624783
115MAP3K40.45234804
116WNK40.45059483
117PAK10.44486525
118EIF2AK20.44438202
119* CSNK2A10.43775857
120GRK10.42905132
121PTK60.42298304
122MST40.41945077
123PINK10.40536032
124CDK190.40492904
125EIF2AK30.39030225
126DYRK1A0.38915602
127STK390.38605369
128MAPKAPK30.37671860
129MAPK140.37465478
130MELK0.37066900
131PRKACB0.35310520
132CSNK1A10.33792515
133ERBB40.33722769
134PRKCE0.33171254
135CAMK1G0.32805230

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91180053
2Spliceosome_Homo sapiens_hsa030403.39252995
3Mismatch repair_Homo sapiens_hsa034303.28011268
4RNA transport_Homo sapiens_hsa030132.85141329
5* Cell cycle_Homo sapiens_hsa041102.74642827
6Protein export_Homo sapiens_hsa030602.71287580
7Ribosome_Homo sapiens_hsa030102.41101121
8mRNA surveillance pathway_Homo sapiens_hsa030152.41020399
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36587536
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26388559
11Base excision repair_Homo sapiens_hsa034102.22123749
12Nucleotide excision repair_Homo sapiens_hsa034202.21260061
13Steroid biosynthesis_Homo sapiens_hsa001002.19202061
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09536990
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95008333
16Parkinsons disease_Homo sapiens_hsa050121.82112700
17Oxidative phosphorylation_Homo sapiens_hsa001901.78186952
18Propanoate metabolism_Homo sapiens_hsa006401.74915390
19Oocyte meiosis_Homo sapiens_hsa041141.73277388
20Homologous recombination_Homo sapiens_hsa034401.70284085
21Colorectal cancer_Homo sapiens_hsa052101.68113984
22RNA degradation_Homo sapiens_hsa030181.64756809
23Basal cell carcinoma_Homo sapiens_hsa052171.61536197
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58780024
25Proteasome_Homo sapiens_hsa030501.57246872
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55461597
27RNA polymerase_Homo sapiens_hsa030201.54965571
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.53264046
29Nicotine addiction_Homo sapiens_hsa050331.52996938
30Hippo signaling pathway_Homo sapiens_hsa043901.48846543
31Fanconi anemia pathway_Homo sapiens_hsa034601.44681024
32p53 signaling pathway_Homo sapiens_hsa041151.41309514
33Huntingtons disease_Homo sapiens_hsa050161.39623333
34Non-homologous end-joining_Homo sapiens_hsa034501.39080564
35Pyruvate metabolism_Homo sapiens_hsa006201.36701805
36Hedgehog signaling pathway_Homo sapiens_hsa043401.35802368
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35777186
38MicroRNAs in cancer_Homo sapiens_hsa052061.33813780
39One carbon pool by folate_Homo sapiens_hsa006701.30432587
40Pyrimidine metabolism_Homo sapiens_hsa002401.30336095
41Basal transcription factors_Homo sapiens_hsa030221.28898757
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26690849
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26099325
44Systemic lupus erythematosus_Homo sapiens_hsa053221.25471122
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25444440
46Thyroid cancer_Homo sapiens_hsa052161.23944130
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23064910
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22968388
49* Alcoholism_Homo sapiens_hsa050341.21888547
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20371320
51Wnt signaling pathway_Homo sapiens_hsa043101.19890838
52TGF-beta signaling pathway_Homo sapiens_hsa043501.18138616
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14411294
54Endometrial cancer_Homo sapiens_hsa052131.14287554
55* Viral carcinogenesis_Homo sapiens_hsa052031.10359010
56HTLV-I infection_Homo sapiens_hsa051661.08383391
57Biosynthesis of amino acids_Homo sapiens_hsa012301.04717481
58Adherens junction_Homo sapiens_hsa045201.03512303
59* Chronic myeloid leukemia_Homo sapiens_hsa052201.02842002
60Phototransduction_Homo sapiens_hsa047441.00357889
61mTOR signaling pathway_Homo sapiens_hsa041500.97765751
62Small cell lung cancer_Homo sapiens_hsa052220.94304489
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92047472
64Bladder cancer_Homo sapiens_hsa052190.91848810
65Non-small cell lung cancer_Homo sapiens_hsa052230.91514006
66Fatty acid elongation_Homo sapiens_hsa000620.91464015
67Alzheimers disease_Homo sapiens_hsa050100.91020327
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90022530
69Glioma_Homo sapiens_hsa052140.89336477
70Axon guidance_Homo sapiens_hsa043600.88253007
71Butanoate metabolism_Homo sapiens_hsa006500.86897349
72* Epstein-Barr virus infection_Homo sapiens_hsa051690.86441865
73Viral myocarditis_Homo sapiens_hsa054160.85657634
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.84587153
75N-Glycan biosynthesis_Homo sapiens_hsa005100.84120583
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82900841
77Proteoglycans in cancer_Homo sapiens_hsa052050.82790650
78* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79035699
79Pancreatic cancer_Homo sapiens_hsa052120.78954057
80Cardiac muscle contraction_Homo sapiens_hsa042600.78745888
81Tight junction_Homo sapiens_hsa045300.77301551
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75252350
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.74429482
84* Pathways in cancer_Homo sapiens_hsa052000.74323097
85Carbon metabolism_Homo sapiens_hsa012000.72822850
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72808737
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72628021
88* Notch signaling pathway_Homo sapiens_hsa043300.72399722
89Gap junction_Homo sapiens_hsa045400.72004908
90Melanogenesis_Homo sapiens_hsa049160.71886287
91Taste transduction_Homo sapiens_hsa047420.67271712
92VEGF signaling pathway_Homo sapiens_hsa043700.67032752
93GABAergic synapse_Homo sapiens_hsa047270.63843982
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63603122
95* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62122500
96Focal adhesion_Homo sapiens_hsa045100.61744062
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60935081
98Renal cell carcinoma_Homo sapiens_hsa052110.60591805
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60584166
100Shigellosis_Homo sapiens_hsa051310.60554524
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59883370
102Lysine degradation_Homo sapiens_hsa003100.59869308
103Prostate cancer_Homo sapiens_hsa052150.59183510
104Vitamin B6 metabolism_Homo sapiens_hsa007500.58782439
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58620776
106Arginine and proline metabolism_Homo sapiens_hsa003300.58382731
107Dopaminergic synapse_Homo sapiens_hsa047280.57388811
108Herpes simplex infection_Homo sapiens_hsa051680.56308633
109Estrogen signaling pathway_Homo sapiens_hsa049150.55891195
110Metabolic pathways_Homo sapiens_hsa011000.55405675
111Purine metabolism_Homo sapiens_hsa002300.55230517
112Hepatitis B_Homo sapiens_hsa051610.54472233
113Long-term potentiation_Homo sapiens_hsa047200.54009173
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53319156
115Melanoma_Homo sapiens_hsa052180.52990642
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51435073
117Folate biosynthesis_Homo sapiens_hsa007900.50938781
118ErbB signaling pathway_Homo sapiens_hsa040120.50680870
119beta-Alanine metabolism_Homo sapiens_hsa004100.50652610
120Fatty acid metabolism_Homo sapiens_hsa012120.49085331
121Regulation of autophagy_Homo sapiens_hsa041400.46901196
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46650158
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44636966
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43053172
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43044861
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42898000
127Insulin signaling pathway_Homo sapiens_hsa049100.42639309
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41311334
129Antigen processing and presentation_Homo sapiens_hsa046120.39895094
130Rap1 signaling pathway_Homo sapiens_hsa040150.39149042
131Selenocompound metabolism_Homo sapiens_hsa004500.39098402
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39035216
133AMPK signaling pathway_Homo sapiens_hsa041520.37037033
134Glutathione metabolism_Homo sapiens_hsa004800.36561999
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36540312
136FoxO signaling pathway_Homo sapiens_hsa040680.35669676
137GnRH signaling pathway_Homo sapiens_hsa049120.35229214
138Morphine addiction_Homo sapiens_hsa050320.34673874
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34500928
140Tryptophan metabolism_Homo sapiens_hsa003800.33295809
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32598040
142Acute myeloid leukemia_Homo sapiens_hsa052210.32458291
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31808745
144Sulfur relay system_Homo sapiens_hsa041220.31242921
145ECM-receptor interaction_Homo sapiens_hsa045120.30815771
146Glutamatergic synapse_Homo sapiens_hsa047240.30796980
147Peroxisome_Homo sapiens_hsa041460.29886261
148Olfactory transduction_Homo sapiens_hsa047400.29619951
149Amphetamine addiction_Homo sapiens_hsa050310.29197223
150Cocaine addiction_Homo sapiens_hsa050300.28874874
151Fatty acid degradation_Homo sapiens_hsa000710.28533575
152Ether lipid metabolism_Homo sapiens_hsa005650.27719865
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.27322437
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26411513
155Platelet activation_Homo sapiens_hsa046110.25286798
156Serotonergic synapse_Homo sapiens_hsa047260.25253735
157Oxytocin signaling pathway_Homo sapiens_hsa049210.24811160
158Fat digestion and absorption_Homo sapiens_hsa049750.24324753
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24155891

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