HDAC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.77518230
2peptidyl-arginine omega-N-methylation (GO:0035247)4.47971623
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.30783156
4nuclear pore complex assembly (GO:0051292)4.04566696
5proline biosynthetic process (GO:0006561)4.04161304
6DNA strand elongation (GO:0022616)3.99025762
7negative regulation of RNA splicing (GO:0033119)3.95228848
8mitotic chromosome condensation (GO:0007076)3.93384364
9formation of translation preinitiation complex (GO:0001731)3.92988932
10ribosome assembly (GO:0042255)3.90262831
11negative regulation of microtubule polymerization (GO:0031115)3.88177909
12COPI coating of Golgi vesicle (GO:0048205)3.83878283
13Golgi transport vesicle coating (GO:0048200)3.83878283
14establishment of viral latency (GO:0019043)3.80030199
15mitotic sister chromatid segregation (GO:0000070)3.75054606
16mitotic metaphase plate congression (GO:0007080)3.74697141
17peptidyl-arginine methylation (GO:0018216)3.72212489
18peptidyl-arginine N-methylation (GO:0035246)3.72212489
19nuclear pore organization (GO:0006999)3.67888793
20positive regulation of receptor biosynthetic process (GO:0010870)3.67329727
21DNA strand elongation involved in DNA replication (GO:0006271)3.65772968
22protein localization to kinetochore (GO:0034501)3.63849334
23telomere maintenance via recombination (GO:0000722)3.54294893
24protein localization to chromosome, centromeric region (GO:0071459)3.49657464
25ribosomal small subunit assembly (GO:0000028)3.45457776
26heterochromatin organization (GO:0070828)3.43310603
27viral transcription (GO:0019083)3.39385051
28mitotic recombination (GO:0006312)3.37788803
29mitotic nuclear envelope disassembly (GO:0007077)3.37095553
30DNA topological change (GO:0006265)3.37051151
31negative regulation of mRNA processing (GO:0050686)3.33633038
32sister chromatid segregation (GO:0000819)3.32495344
33translational elongation (GO:0006414)3.30703365
34purine nucleobase biosynthetic process (GO:0009113)3.30274398
35tricarboxylic acid cycle (GO:0006099)3.29720913
36translational termination (GO:0006415)3.29123265
37peptidyl-lysine dimethylation (GO:0018027)3.27186504
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.21921339
39oxaloacetate metabolic process (GO:0006107)3.20903764
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18652984
41histone arginine methylation (GO:0034969)3.16760598
42nucleobase-containing small molecule interconversion (GO:0015949)3.15222933
43L-serine metabolic process (GO:0006563)3.14192160
44regulation of protein heterodimerization activity (GO:0043497)3.14190219
45DNA replication checkpoint (GO:0000076)3.12873383
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11369591
47pentose-phosphate shunt (GO:0006098)3.09101435
48membrane disassembly (GO:0030397)3.08738263
49nuclear envelope disassembly (GO:0051081)3.08738263
50nucleobase biosynthetic process (GO:0046112)3.07785131
51layer formation in cerebral cortex (GO:0021819)3.07000896
52IMP biosynthetic process (GO:0006188)3.06938431
53glial cell proliferation (GO:0014009)3.05791739
54CENP-A containing nucleosome assembly (GO:0034080)3.04957022
55regulation of translational fidelity (GO:0006450)3.03750739
56negative regulation of chromosome segregation (GO:0051985)3.01471512
57chromatin remodeling at centromere (GO:0031055)3.00354148
58pore complex assembly (GO:0046931)2.99483215
59ribosome biogenesis (GO:0042254)2.99362805
60regulation of mitochondrial translation (GO:0070129)2.99338743
61energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97047530
62ATP synthesis coupled proton transport (GO:0015986)2.97047530
63negative regulation of mRNA metabolic process (GO:1903312)2.93539798
64negative regulation of sister chromatid segregation (GO:0033046)2.92917750
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92917750
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92917750
67negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92917750
68negative regulation of mitotic sister chromatid separation (GO:2000816)2.92917750
69ribosomal large subunit biogenesis (GO:0042273)2.92836515
70protein complex localization (GO:0031503)2.91285863
71mitotic G1 DNA damage checkpoint (GO:0031571)2.89910914
72IMP metabolic process (GO:0046040)2.89563321
73spindle checkpoint (GO:0031577)2.89218693
74metaphase plate congression (GO:0051310)2.88998304
75regulation of mitotic spindle organization (GO:0060236)2.88693793
76translational initiation (GO:0006413)2.88638652
77transcription-coupled nucleotide-excision repair (GO:0006283)2.88548866
78viral mRNA export from host cell nucleus (GO:0046784)2.87862727
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87855680
80mitotic spindle checkpoint (GO:0071174)2.87683053
81ribonucleoprotein complex biogenesis (GO:0022613)2.86837432
82spliceosomal tri-snRNP complex assembly (GO:0000244)2.86797069
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86458194
84DNA replication-independent nucleosome assembly (GO:0006336)2.86326014
85DNA replication-independent nucleosome organization (GO:0034724)2.86326014
86NADH metabolic process (GO:0006734)2.86198069
87succinate metabolic process (GO:0006105)2.85993473
88oxidative phosphorylation (GO:0006119)2.84723763
89protein complex disassembly (GO:0043241)2.82886706
90cellular protein complex disassembly (GO:0043624)2.82164687
91tRNA aminoacylation for protein translation (GO:0006418)2.82125727
92spliceosomal snRNP assembly (GO:0000387)2.81456540
93cotranslational protein targeting to membrane (GO:0006613)2.81222838
94mitotic spindle assembly checkpoint (GO:0007094)2.80985772
95DNA replication-dependent nucleosome organization (GO:0034723)2.80913071
96establishment of integrated proviral latency (GO:0075713)2.80691456
97proteasome assembly (GO:0043248)2.80595228
98maturation of SSU-rRNA (GO:0030490)2.80509638
99maternal placenta development (GO:0001893)2.80035878
100galactose catabolic process (GO:0019388)2.80007912
101protein targeting to ER (GO:0045047)2.79635409
102base-excision repair (GO:0006284)2.79189227
103ribosomal small subunit biogenesis (GO:0042274)2.76810838
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.76315824
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75658885
106telomere maintenance via semi-conservative replication (GO:0032201)2.75466156
107spindle assembly checkpoint (GO:0071173)2.74801863
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74733528
109DNA replication initiation (GO:0006270)2.74024832
110activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.73043794
111termination of RNA polymerase II transcription (GO:0006369)2.72944505
112regulation of chromosome segregation (GO:0051983)2.72320013
113chromatin assembly or disassembly (GO:0006333)2.71005687
114establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69817180
115viral life cycle (GO:0019058)2.69690777
116tRNA aminoacylation (GO:0043039)2.69064287
117amino acid activation (GO:0043038)2.69064287
118establishment of chromosome localization (GO:0051303)2.69007994
119histone H2A acetylation (GO:0043968)2.66768550
120protein maturation by protein folding (GO:0022417)2.66220626
121macromolecular complex disassembly (GO:0032984)2.66213762
122regulation of translational termination (GO:0006449)2.65866647
123pentose metabolic process (GO:0019321)2.65664983
124glycolytic process (GO:0006096)2.64893237
125chromatin assembly (GO:0031497)2.64744098
126protein localization to endoplasmic reticulum (GO:0070972)2.62182263
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60413967
128DNA deamination (GO:0045006)2.59508254
129synaptic vesicle maturation (GO:0016188)2.59414270
130NADPH regeneration (GO:0006740)2.59327728
131ectodermal placode formation (GO:0060788)2.59204285
132negative regulation of ligase activity (GO:0051352)2.55927520
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55927520
134de novo posttranslational protein folding (GO:0051084)2.53355642
135glucocorticoid receptor signaling pathway (GO:0042921)2.51572482
136regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50867299
137negative regulation of cell size (GO:0045792)2.49859703
138protein-DNA complex disassembly (GO:0032986)2.49781658
139nucleosome disassembly (GO:0006337)2.49781658
140DNA duplex unwinding (GO:0032508)2.49238310
141L-serine transport (GO:0015825)2.49140491
142mRNA splicing, via spliceosome (GO:0000398)2.49071104
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49071104
144de novo protein folding (GO:0006458)2.48690027
145positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47396865
146spliceosomal complex assembly (GO:0000245)2.47205157
147retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47077659
148cullin deneddylation (GO:0010388)2.46675259
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46513011
150telomere maintenance via telomere lengthening (GO:0010833)2.45726914
151tricarboxylic acid metabolic process (GO:0072350)2.45683815
152folic acid-containing compound biosynthetic process (GO:0009396)2.45327417
153anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44231518
154DNA geometric change (GO:0032392)2.41449265
155ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.39854955
156regulation of DNA damage checkpoint (GO:2000001)2.39283818
157RNA splicing, via transesterification reactions (GO:0000375)2.38684331
158positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.37656584
159synaptic vesicle exocytosis (GO:0016079)2.36976439
160regulation of sister chromatid cohesion (GO:0007063)2.36210406
161protein deneddylation (GO:0000338)2.35350507
162DNA replication-dependent nucleosome assembly (GO:0006335)2.35219381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19188392
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.73939368
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79489466
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97100913
5ESR1_15608294_ChIP-ChIP_MCF-7_Human2.86401488
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72723639
7MYC_22102868_ChIP-Seq_BL_Human2.65985867
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61934307
9XRN2_22483619_ChIP-Seq_HELA_Human2.58935537
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.55852401
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34116266
12ZFX_18555785_ChIP-Seq_MESCs_Mouse2.23030758
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.22023706
14CIITA_25753668_ChIP-Seq_RAJI_Human2.19482428
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16717500
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14710557
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.11734313
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08234389
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00549092
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.95437767
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92998745
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92862359
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91386369
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89822916
25GABP_19822575_ChIP-Seq_HepG2_Human1.79432890
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75142124
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71433221
28ZNF263_19887448_ChIP-Seq_K562_Human1.70762947
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70058578
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68147163
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65602648
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61946981
33TTF2_22483619_ChIP-Seq_HELA_Human1.61490524
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60767683
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60576997
36DCP1A_22483619_ChIP-Seq_HELA_Human1.59020245
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58765841
38FOXP3_21729870_ChIP-Seq_TREG_Human1.58540163
39VDR_21846776_ChIP-Seq_THP-1_Human1.58386440
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58324607
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58261092
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56239518
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52379332
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50435074
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49729213
46KDM5A_27292631_Chip-Seq_BREAST_Human1.46193550
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43402595
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43131157
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41511827
50LXR_22292898_ChIP-Seq_THP-1_Human1.41075915
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41064265
52AR_21909140_ChIP-Seq_LNCAP_Human1.35818616
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35714124
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34069349
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33798953
56TFEB_21752829_ChIP-Seq_HELA_Human1.33639623
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33395869
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33239698
59VDR_23849224_ChIP-Seq_CD4+_Human1.32289743
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.32038599
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31995177
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.31435928
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30622326
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29859849
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27316482
66CLOCK_20551151_ChIP-Seq_293T_Human1.27077589
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26956999
68* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26334933
69TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26252215
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25901913
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24751745
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24716845
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24584386
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22021289
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21694744
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21249791
77TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20441764
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19407384
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17761799
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17557363
81* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16296839
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15146351
83EZH2_22144423_ChIP-Seq_EOC_Human1.15006772
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14744138
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.14597573
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13623014
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12840185
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11903577
89ELK1_19687146_ChIP-ChIP_HELA_Human1.11555268
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11101070
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10968668
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.09655877
93CHD1_26751641_Chip-Seq_LNCaP_Human1.09157517
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09019143
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08553990
96* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08099603
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.07640717
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07191040
99P68_20966046_ChIP-Seq_HELA_Human1.06012876
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05908682
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.05333815
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05095648
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04965072
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04238260
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03559972
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01436716
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.01151331
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01126332
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00319792
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98645231
111KDM2B_26808549_Chip-Seq_DND41_Human0.98638779
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98516270
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98307167
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97421841
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.97395033
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97190968
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95963011
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95590534
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95446340
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93797912
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93792248
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93374520
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93122222
124NCOR1_26117541_ChIP-Seq_K562_Human0.92119446
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91914919
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88528008
127SPI1_23547873_ChIP-Seq_NB4_Human0.87810245
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86265594
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.84663438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.50036709
2MP0003123_paternal_imprinting3.42383401
3MP0004859_abnormal_synaptic_plasticity3.27892531
4MP0010234_abnormal_vibrissa_follicle3.27342045
5MP0008058_abnormal_DNA_repair3.01052211
6MP0005451_abnormal_body_composition2.68008132
7MP0000537_abnormal_urethra_morphology2.49391040
8MP0003122_maternal_imprinting2.42920626
9MP0004233_abnormal_muscle_weight2.42668459
10MP0004957_abnormal_blastocyst_morpholog2.39643354
11MP0006054_spinal_hemorrhage2.39310397
12MP0010352_gastrointestinal_tract_polyps2.38826900
13MP0003635_abnormal_synaptic_transmissio2.31169318
14MP0003283_abnormal_digestive_organ2.30246537
15MP0008057_abnormal_DNA_replication2.24415051
16MP0003806_abnormal_nucleotide_metabolis2.22305365
17MP0008260_abnormal_autophagy2.17508903
18MP0000751_myopathy2.14482484
19MP0003329_amyloid_beta_deposits2.12214542
20MP0010094_abnormal_chromosome_stability2.08398340
21MP0009697_abnormal_copulation1.98141627
22MP0003121_genomic_imprinting1.94938088
23MP0005187_abnormal_penis_morphology1.92156670
24MP0003941_abnormal_skin_development1.91573486
25MP0005058_abnormal_lysosome_morphology1.91546290
26MP0003221_abnormal_cardiomyocyte_apopto1.90046148
27MP0002132_abnormal_respiratory_system1.87754551
28MP0001730_embryonic_growth_arrest1.85347817
29MP0002234_abnormal_pharynx_morphology1.83553986
30MP0003111_abnormal_nucleus_morphology1.77070916
31MP0003786_premature_aging1.76107659
32MP0003186_abnormal_redox_activity1.70154976
33MP0009333_abnormal_splenocyte_physiolog1.61984045
34MP0003705_abnormal_hypodermis_morpholog1.60057813
35MP0004811_abnormal_neuron_physiology1.59590028
36MP0000490_abnormal_crypts_of1.56494641
37MP0005501_abnormal_skin_physiology1.54434334
38MP0004858_abnormal_nervous_system1.52033852
39* MP0003077_abnormal_cell_cycle1.51831081
40MP0000534_abnormal_ureter_morphology1.51262032
41MP0003880_abnormal_central_pattern1.48878685
42MP0002909_abnormal_adrenal_gland1.48365326
43MP0002877_abnormal_melanocyte_morpholog1.47621808
44MP0002089_abnormal_postnatal_growth/wei1.46349513
45MP0003656_abnormal_erythrocyte_physiolo1.44799239
46MP0000678_abnormal_parathyroid_gland1.42724555
47MP0006072_abnormal_retinal_apoptosis1.41709587
48MP0003942_abnormal_urinary_system1.39592433
49MP0010030_abnormal_orbit_morphology1.38517878
50MP0002063_abnormal_learning/memory/cond1.34837619
51MP0003718_maternal_effect1.34393989
52* MP0002080_prenatal_lethality1.33581143
53MP0003315_abnormal_perineum_morphology1.32014539
54MP0001697_abnormal_embryo_size1.30576736
55MP0000747_muscle_weakness1.29890060
56MP0004145_abnormal_muscle_electrophysio1.28087139
57MP0000013_abnormal_adipose_tissue1.27922727
58MP0002163_abnormal_gland_morphology1.27711779
59MP0009745_abnormal_behavioral_response1.27196014
60MP0002064_seizures1.26762577
61MP0001849_ear_inflammation1.26030765
62MP0002184_abnormal_innervation1.24185486
63MP0003119_abnormal_digestive_system1.23689593
64MP0008932_abnormal_embryonic_tissue1.22974989
65* MP0000358_abnormal_cell_content/1.22779475
66MP0002796_impaired_skin_barrier1.21267074
67* MP0002084_abnormal_developmental_patter1.20776248
68MP0002019_abnormal_tumor_incidence1.18215516
69MP0002837_dystrophic_cardiac_calcinosis1.18140486
70MP0010307_abnormal_tumor_latency1.16775142
71MP0003861_abnormal_nervous_system1.16300572
72MP0004270_analgesia1.15849886
73MP0008770_decreased_survivor_rate1.15835649
74MP0002086_abnormal_extraembryonic_tissu1.15455406
75MP0009278_abnormal_bone_marrow1.15152849
76MP0003879_abnormal_hair_cell1.14922549
77MP0000955_abnormal_spinal_cord1.14565397
78MP0008877_abnormal_DNA_methylation1.13820967
79MP0009379_abnormal_foot_pigmentation1.13215366
80MP0008007_abnormal_cellular_replicative1.11718375
81MP0002269_muscular_atrophy1.11538622
82* MP0000350_abnormal_cell_proliferation1.10603038
83* MP0006035_abnormal_mitochondrial_morpho1.08233862
84MP0004215_abnormal_myocardial_fiber1.07394259
85MP0002085_abnormal_embryonic_tissue1.07225086
86MP0008569_lethality_at_weaning1.06780042
87MP0001545_abnormal_hematopoietic_system1.06317260
88MP0005397_hematopoietic_system_phenotyp1.06317260
89MP0000428_abnormal_craniofacial_morphol1.05119385
90MP0003566_abnormal_cell_adhesion1.05024325
91MP0004130_abnormal_muscle_cell1.03866785
92MP0001529_abnormal_vocalization1.03170634
93MP0003115_abnormal_respiratory_system1.02785637
94MP0004133_heterotaxia1.01854538
95MP0003787_abnormal_imprinting1.01274250
96MP0001661_extended_life_span1.00434369
97MP0002152_abnormal_brain_morphology1.00343583
98MP0002396_abnormal_hematopoietic_system1.00307442
99MP0005464_abnormal_platelet_physiology0.99810351
100MP0004197_abnormal_fetal_growth/weight/0.98299986
101MP0000858_altered_metastatic_potential0.97345181
102MP0003385_abnormal_body_wall0.96382089
103MP0009672_abnormal_birth_weight0.96160908
104MP0001853_heart_inflammation0.95842486
105MP0000703_abnormal_thymus_morphology0.95183125
106MP0004185_abnormal_adipocyte_glucose0.94635254
107MP0008438_abnormal_cutaneous_collagen0.94464250
108MP0005623_abnormal_meninges_morphology0.94364484
109MP0004808_abnormal_hematopoietic_stem0.93723335
110MP0001293_anophthalmia0.90375977
111MP0000759_abnormal_skeletal_muscle0.89021004
112MP0002722_abnormal_immune_system0.88943328
113MP0003567_abnormal_fetal_cardiomyocyte0.88906302
114* MP0005384_cellular_phenotype0.88852577
115MP0001727_abnormal_embryo_implantation0.88597923
116MP0003300_gastrointestinal_ulcer0.88109063
117MP0000049_abnormal_middle_ear0.87754920
118MP0002111_abnormal_tail_morphology0.85970528
119MP0002882_abnormal_neuron_morphology0.85618565
120MP0008789_abnormal_olfactory_epithelium0.83942728
121MP0005257_abnormal_intraocular_pressure0.83072074
122MP0002092_abnormal_eye_morphology0.81234880
123MP0000631_abnormal_neuroendocrine_gland0.80567679
124MP0000689_abnormal_spleen_morphology0.80016080
125MP0002653_abnormal_ependyma_morphology0.78660039
126MP0005380_embryogenesis_phenotype0.78334361
127MP0001672_abnormal_embryogenesis/_devel0.78334361
128MP0002114_abnormal_axial_skeleton0.78273815
129MP0002398_abnormal_bone_marrow0.77933393
130MP0003984_embryonic_growth_retardation0.77782660
131MP0005220_abnormal_exocrine_pancreas0.77737734
132MP0002272_abnormal_nervous_system0.77646175
133* MP0005621_abnormal_cell_physiology0.77471629
134MP0001968_abnormal_touch/_nociception0.77396248
135MP0009053_abnormal_anal_canal0.76420141
136* MP0000313_abnormal_cell_death0.76099011
137MP0004087_abnormal_muscle_fiber0.75958574
138MP0002088_abnormal_embryonic_growth/wei0.75958462
139MP0000003_abnormal_adipose_tissue0.75782921
140MP0000750_abnormal_muscle_regeneration0.75290985
141MP0005394_taste/olfaction_phenotype0.73992356
142MP0005499_abnormal_olfactory_system0.73992356
143MP0002697_abnormal_eye_size0.73772493
144MP0002557_abnormal_social/conspecific_i0.73690461
145MP0002429_abnormal_blood_cell0.73347115
146MP0002572_abnormal_emotion/affect_behav0.72886309
147* MP0006036_abnormal_mitochondrial_physio0.72339035
148MP0009703_decreased_birth_body0.72121253
149MP0009840_abnormal_foam_cell0.71486975
150MP0003937_abnormal_limbs/digits/tail_de0.71424892
151MP0001270_distended_abdomen0.70692034
152MP0000778_abnormal_nervous_system0.70558792
153MP0010769_abnormal_survival0.70100979
154MP0003136_yellow_coat_color0.65910008
155MP0002233_abnormal_nose_morphology0.64745407
156MP0002210_abnormal_sex_determination0.63942359
157MP0001346_abnormal_lacrimal_gland0.63064239
158MP0001915_intracranial_hemorrhage0.62329151
159MP0005379_endocrine/exocrine_gland_phen0.61989268
160MP0001881_abnormal_mammary_gland0.61225546
161* MP0000598_abnormal_liver_morphology0.58642535
162MP0001216_abnormal_epidermal_layer0.58584010
163MP0003453_abnormal_keratinocyte_physiol0.57874663
164MP0004272_abnormal_basement_membrane0.55931300

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)4.81460025
2Cholecystitis (HP:0001082)4.81460025
3Microvesicular hepatic steatosis (HP:0001414)4.22502219
4Visual hallucinations (HP:0002367)3.98446519
5Multiple enchondromatosis (HP:0005701)3.34497953
6Ragged-red muscle fibers (HP:0003200)3.29814963
7Abnormality of the lower motor neuron (HP:0002366)3.21008804
8Colon cancer (HP:0003003)3.19258989
9Chromsome breakage (HP:0040012)2.91681104
10Selective tooth agenesis (HP:0001592)2.89701486
11Progressive muscle weakness (HP:0003323)2.86949792
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86225492
13Adenoma sebaceum (HP:0009720)2.85519658
14Angiofibromas (HP:0010615)2.85519658
15Reticulocytosis (HP:0001923)2.82913532
16Abnormality of reticulocytes (HP:0004312)2.81532793
17Reticulocytopenia (HP:0001896)2.78617900
18Increased serum pyruvate (HP:0003542)2.71690859
19Abnormality of glycolysis (HP:0004366)2.71690859
20Abnormality of cells of the erythroid lineage (HP:0012130)2.69586080
21Calcaneovalgus deformity (HP:0001848)2.69039802
22Ependymoma (HP:0002888)2.68332169
23Abnormal number of erythroid precursors (HP:0012131)2.60615938
24Hepatocellular necrosis (HP:0001404)2.57163825
25Abnormality of oral frenula (HP:0000190)2.53083198
26Degeneration of anterior horn cells (HP:0002398)2.52440391
27Abnormality of the anterior horn cell (HP:0006802)2.52440391
28Spastic diplegia (HP:0001264)2.52068682
29Abnormal mitochondria in muscle tissue (HP:0008316)2.51043053
30Cholelithiasis (HP:0001081)2.48405050
31Ankyloglossia (HP:0010296)2.47525614
32Insomnia (HP:0100785)2.45809235
33Abnormality of the calcaneus (HP:0008364)2.45337360
34Rough bone trabeculation (HP:0100670)2.43052372
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42945179
36Progressive external ophthalmoplegia (HP:0000590)2.41568356
37Pointed chin (HP:0000307)2.41563705
38Hyperacusis (HP:0010780)2.41268986
39Deformed tarsal bones (HP:0008119)2.40359167
40Neoplasm of the peripheral nervous system (HP:0100007)2.39768640
41Annular pancreas (HP:0001734)2.37482901
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.32986431
43Abnormality of the umbilical cord (HP:0010881)2.32371767
44Buphthalmos (HP:0000557)2.31576888
45Amyotrophic lateral sclerosis (HP:0007354)2.30643338
46Pelvic girdle muscle weakness (HP:0003749)2.28407281
47Basal cell carcinoma (HP:0002671)2.27106142
48Premature ovarian failure (HP:0008209)2.25793450
49Shoulder girdle muscle weakness (HP:0003547)2.25689568
50Large eyes (HP:0001090)2.23203354
51Abnormal gallbladder morphology (HP:0012437)2.22404122
52Megalencephaly (HP:0001355)2.18921043
53Emotional lability (HP:0000712)2.15713343
54Squamous cell carcinoma (HP:0002860)2.14209842
55Abnormality of the preputium (HP:0100587)2.10555772
56Single umbilical artery (HP:0001195)2.09581383
57Abnormality of the fetal cardiovascular system (HP:0010948)2.09581383
58Abnormal umbilical cord blood vessels (HP:0011403)2.09581383
59Renal duplication (HP:0000075)2.09437527
60Limb-girdle muscle atrophy (HP:0003797)2.07609452
61Focal motor seizures (HP:0011153)2.07604716
62Prominent metopic ridge (HP:0005487)2.07429629
63Bowel diverticulosis (HP:0005222)2.07015122
64Short 4th metacarpal (HP:0010044)2.06809643
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06809643
66Abnormality of the astrocytes (HP:0100707)2.05542362
67Astrocytoma (HP:0009592)2.05542362
68Secondary amenorrhea (HP:0000869)2.04761807
69Depression (HP:0000716)2.04542990
70Pallor (HP:0000980)2.04203349
71Abnormal tarsal ossification (HP:0008369)2.03663030
72Birth length less than 3rd percentile (HP:0003561)2.03431956
73Abnormality of the gallbladder (HP:0005264)2.03390885
74Abnormal trabecular bone morphology (HP:0100671)2.02917398
75Horseshoe kidney (HP:0000085)2.02268673
76Hypoplasia of the pons (HP:0012110)2.01181141
77Intestinal polyp (HP:0005266)2.01152640
78Fibrous tissue neoplasm (HP:0012316)2.00250239
79Fibroma (HP:0010614)1.99899838
80Termporal pattern (HP:0011008)1.98633781
81Insidious onset (HP:0003587)1.98633781
82Adducted thumb (HP:0001181)1.98256144
83Protrusio acetabuli (HP:0003179)1.97571179
84Back pain (HP:0003418)1.97392863
85Intestinal polyposis (HP:0200008)1.96172821
86Macrocytic anemia (HP:0001972)1.95815145
87Hepatosplenomegaly (HP:0001433)1.95205561
88Nephroblastoma (Wilms tumor) (HP:0002667)1.94902816
89Type I transferrin isoform profile (HP:0003642)1.94494769
90Neuroendocrine neoplasm (HP:0100634)1.93212858
91Lissencephaly (HP:0001339)1.92915955
92Trismus (HP:0000211)1.92614596
93Abnormality of the 4th metacarpal (HP:0010012)1.91299611
94Testicular atrophy (HP:0000029)1.90928991
95High anterior hairline (HP:0009890)1.90603359
96Hypoventilation (HP:0002791)1.90201714
97Hypertensive crisis (HP:0100735)1.87336016
98Proximal placement of thumb (HP:0009623)1.87229822
99Broad distal phalanx of finger (HP:0009836)1.85544982
100Absence seizures (HP:0002121)1.85520315
101Hepatic necrosis (HP:0002605)1.85258098
102Meckel diverticulum (HP:0002245)1.84590869
103Myelodysplasia (HP:0002863)1.84430590
104Neoplasm of the pancreas (HP:0002894)1.83846457
105Missing ribs (HP:0000921)1.83520960
106Neoplasm of head and neck (HP:0012288)1.83243014
107Esophageal neoplasm (HP:0100751)1.83243014
108Pheochromocytoma (HP:0002666)1.83025463
109Urinary urgency (HP:0000012)1.82830442
110Medulloblastoma (HP:0002885)1.82482795
111Upper motor neuron abnormality (HP:0002127)1.82453817
112Neoplasm of the rectum (HP:0100743)1.82103987
113Conjunctival hamartoma (HP:0100780)1.81054262
114Sacral dimple (HP:0000960)1.80753186
115Papilledema (HP:0001085)1.80693603
116Myoglobinuria (HP:0002913)1.80487414
117Breech presentation (HP:0001623)1.79779777
118Acute necrotizing encephalopathy (HP:0006965)1.79130728
119Abnormal lung lobation (HP:0002101)1.79121285
120Carpal bone hypoplasia (HP:0001498)1.78930928
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78845153
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78845153
123Sparse eyelashes (HP:0000653)1.78434446
124Pancreatic islet-cell hyperplasia (HP:0004510)1.77897558
125Deviation of the thumb (HP:0009603)1.77781938
126Abnormality of the ileum (HP:0001549)1.77509734
127Long palpebral fissure (HP:0000637)1.77454705
128Orthostatic hypotension (HP:0001278)1.76597853
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.75914882
130Rectal prolapse (HP:0002035)1.75813634
131Dysphonia (HP:0001618)1.75685688
13211 pairs of ribs (HP:0000878)1.75350390
133Freckling (HP:0001480)1.75089815
134Vertebral compression fractures (HP:0002953)1.75040654
135Abnormality of methionine metabolism (HP:0010901)1.74465133
136Entropion (HP:0000621)1.74137030
137Abnormal foot bone ossification (HP:0010675)1.73638992
138Exostoses (HP:0100777)1.73622856
139Neuroblastic tumors (HP:0004376)1.73256309
140Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.73256309
141Neuroblastoma (HP:0003006)1.73256309
142Primitive neuroectodermal tumor (HP:0030065)1.73256309
143Ankle contracture (HP:0006466)1.72971065
144Short middle phalanx of the 5th finger (HP:0004220)1.72529968
145Abnormality of the musculature of the pelvis (HP:0001469)1.72299628
146Abnormality of the hip-girdle musculature (HP:0001445)1.72299628
147Embryonal renal neoplasm (HP:0011794)1.71798147
148Seborrheic dermatitis (HP:0001051)1.71521276
149Bladder diverticulum (HP:0000015)1.71117022
150Premature skin wrinkling (HP:0100678)1.70925790
151Patellar dislocation (HP:0002999)1.70634969
152Increased nuchal translucency (HP:0010880)1.69810400
153Poor eye contact (HP:0000817)1.69052830
154Spinal canal stenosis (HP:0003416)1.68241049
155Increased density of long bones (HP:0006392)1.67429052
156Shallow orbits (HP:0000586)1.67091292
157Microretrognathia (HP:0000308)1.67080735
158Megalocornea (HP:0000485)1.66786006
159Myopathic facies (HP:0002058)1.66528332
160Elfin facies (HP:0004428)1.66125304
161Glossoptosis (HP:0000162)1.65384997
162Poor suck (HP:0002033)1.65384986
163Overriding aorta (HP:0002623)1.64765609
164Exercise intolerance (HP:0003546)1.64456039
165Abnormality of chromosome stability (HP:0003220)1.64379855
166Poikiloderma (HP:0001029)1.64239065
167Reduced antithrombin III activity (HP:0001976)1.64163761
168Abnormality of the metopic suture (HP:0005556)1.63799843
169Striae distensae (HP:0001065)1.63618828
170Postnatal microcephaly (HP:0005484)1.63397498
171Abnormality of the pancreatic islet cells (HP:0006476)1.63187142
172Abnormality of endocrine pancreas physiology (HP:0012093)1.63187142
173Mitochondrial inheritance (HP:0001427)1.62741238
174Aplasia/Hypoplasia of the thymus (HP:0010515)1.62656871
175Aplastic anemia (HP:0001915)1.61865889
176Hypercortisolism (HP:0001578)1.61667818
177Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61437164
178Hypoplasia of the brainstem (HP:0002365)1.61437164
179Absent radius (HP:0003974)1.61335480
180Cellular immunodeficiency (HP:0005374)1.61014045
181Metaphyseal cupping (HP:0003021)1.60424080
182Cortical dysplasia (HP:0002539)1.59622349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.33639062
2VRK23.47947304
3SMG13.14257905
4NEK13.03507983
5PKN23.03162300
6LMTK22.70019122
7TRIB32.67683449
8EEF2K2.56623120
9CDC72.54326997
10TTK2.49093549
11SCYL22.42129708
12MAP3K122.34673095
13BUB12.24779326
14EIF2AK12.23382574
15IRAK32.01220296
16TESK21.97129870
17NTRK31.95748365
18WEE11.92983555
19CDK191.91019569
20PBK1.90887044
21MINK11.82917159
22TRIM281.76994228
23BCKDK1.76170018
24MAP3K41.72402560
25CDK121.71549469
26TSSK61.70139089
27PAK41.69574174
28DAPK11.68745035
29MAP2K41.65583348
30TGFBR11.51548846
31PHKG11.49156904
32PHKG21.49156904
33MAP3K101.47350033
34CCNB11.46397980
35MAP3K91.44894873
36PRPF4B1.40671485
37TAOK11.40490362
38TESK11.40446093
39MARK11.37339449
40KSR11.34231657
41LRRK21.31819231
42CDK71.31692957
43CLK11.28308246
44BRSK11.24633833
45SRPK11.24284760
46PASK1.23937001
47PLK11.23180768
48TAF11.22853721
49ICK1.20337002
50PLK41.19732038
51BRSK21.18337996
52LIMK11.17574803
53MAP3K111.17188365
54EIF2AK31.16984132
55MAP2K31.15383999
56TTN1.12349873
57ARAF1.10866186
58PDK41.09278915
59PDK31.09278915
60FGFR11.05968883
61KSR21.05588725
62CDK141.04437325
63CHEK21.04000896
64CDK151.02453148
65MAP2K71.01616133
66CDK180.99788060
67CDK11A0.99557391
68AURKB0.97174812
69PIM20.96344348
70ERN10.94976526
71MST40.92920072
72BMX0.91715815
73PDGFRA0.91070222
74PTK60.90916181
75RET0.90810352
76RPS6KB20.90059388
77BRAF0.89151897
78STK100.87815585
79CHEK10.87783963
80UHMK10.85979702
81TAOK20.83858794
82VRK10.83281062
83AURKA0.83071607
84ILK0.82375798
85CSNK1A1L0.81687960
86STK40.79865789
87RAF10.78291020
88CAMKK10.77087234
89FER0.76029949
90EPHA40.73971068
91ALK0.73485785
92FLT30.73131356
93LATS20.70544909
94CSNK1G10.70146678
95CAMKK20.68849773
96NEK20.68357680
97MAP3K80.65107802
98NME10.64898503
99SIK30.64778685
100PDK20.61424571
101GRK60.61291022
102ACVR1B0.60469111
103SIK10.59482714
104ATM0.59249478
105PAK10.59215788
106EIF2AK20.57968251
107DYRK30.57897239
108CDK50.56954835
109ZAK0.56826596
110DDR20.54943752
111NTRK20.54304378
112RPS6KA40.54105249
113TLK10.53958052
114CSNK2A20.53005363
115CSNK1G30.52820416
116MKNK10.52231974
117CDK20.51628483
118MAP3K60.51495735
119MAPKAPK30.51464545
120DAPK20.51196228
121EPHA20.50213315
122PRKCI0.49810868
123ATR0.49537447
124PAK30.49394094
125* CSNK2A10.49357397
126KDR0.48990733
127STK160.48460645
128ERBB40.48272743
129CDK60.47749805
130RPS6KA20.47633041
131CSNK1G20.46771399
132CDK10.46458231
133CDK90.45219707
134CDK40.45187277
135FGR0.44527197
136DYRK1B0.42240565
137MAP2K60.41308634
138PAK20.41063522
139MAP3K70.40673963
140MAPK90.40552436
141PAK60.39910367
142MAP3K10.39791894
143AKT20.38989763
144PLK30.38933231
145HIPK20.38463886
146IRAK40.38350280
147DAPK30.36271718

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.84924238
2DNA replication_Homo sapiens_hsa030303.70266176
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81909296
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57612731
5Spliceosome_Homo sapiens_hsa030402.48808319
6Mismatch repair_Homo sapiens_hsa034302.48414580
7Non-homologous end-joining_Homo sapiens_hsa034502.37421287
8Proteasome_Homo sapiens_hsa030502.34187823
9Ribosome_Homo sapiens_hsa030102.03300571
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99229176
11RNA polymerase_Homo sapiens_hsa030201.88482514
12Homologous recombination_Homo sapiens_hsa034401.83960280
13Biosynthesis of amino acids_Homo sapiens_hsa012301.83114747
14Base excision repair_Homo sapiens_hsa034101.72816780
15Carbon metabolism_Homo sapiens_hsa012001.70749222
16Pyruvate metabolism_Homo sapiens_hsa006201.69799673
17Nucleotide excision repair_Homo sapiens_hsa034201.65713443
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61144258
19Synaptic vesicle cycle_Homo sapiens_hsa047211.60516134
20Fatty acid elongation_Homo sapiens_hsa000621.55681151
21RNA transport_Homo sapiens_hsa030131.51818026
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50053241
23Fructose and mannose metabolism_Homo sapiens_hsa000511.49279578
24Oocyte meiosis_Homo sapiens_hsa041141.49003457
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47136529
26Steroid biosynthesis_Homo sapiens_hsa001001.43670590
27Cell cycle_Homo sapiens_hsa041101.40166668
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32886210
29mRNA surveillance pathway_Homo sapiens_hsa030151.32570816
30Parkinsons disease_Homo sapiens_hsa050121.29617350
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.29029499
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25845265
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18918878
34Fanconi anemia pathway_Homo sapiens_hsa034601.18891632
35Nicotine addiction_Homo sapiens_hsa050331.18343676
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17308979
37Basal transcription factors_Homo sapiens_hsa030221.16982768
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15633448
39Dopaminergic synapse_Homo sapiens_hsa047281.14613587
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13989185
41N-Glycan biosynthesis_Homo sapiens_hsa005101.10873926
42Long-term potentiation_Homo sapiens_hsa047201.10477259
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.09043597
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.07010956
45Fatty acid biosynthesis_Homo sapiens_hsa000611.04401372
46Other glycan degradation_Homo sapiens_hsa005111.01755800
47Pyrimidine metabolism_Homo sapiens_hsa002400.97871077
48GABAergic synapse_Homo sapiens_hsa047270.96018196
49Colorectal cancer_Homo sapiens_hsa052100.95279508
50Glutathione metabolism_Homo sapiens_hsa004800.94623918
51* Alcoholism_Homo sapiens_hsa050340.93704200
52Circadian entrainment_Homo sapiens_hsa047130.92430803
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91005047
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86785460
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85693476
56Sulfur relay system_Homo sapiens_hsa041220.85478857
57Shigellosis_Homo sapiens_hsa051310.85008387
58Glucagon signaling pathway_Homo sapiens_hsa049220.84975810
59Gap junction_Homo sapiens_hsa045400.83718945
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.83647611
61Oxidative phosphorylation_Homo sapiens_hsa001900.82751269
62Folate biosynthesis_Homo sapiens_hsa007900.82471262
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81510471
64Amphetamine addiction_Homo sapiens_hsa050310.80790503
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79825790
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79661249
67Alzheimers disease_Homo sapiens_hsa050100.79411604
68Glioma_Homo sapiens_hsa052140.79232960
69Vibrio cholerae infection_Homo sapiens_hsa051100.78921304
70p53 signaling pathway_Homo sapiens_hsa041150.78367319
71Huntingtons disease_Homo sapiens_hsa050160.76636323
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71522166
73Insulin signaling pathway_Homo sapiens_hsa049100.71437203
74Oxytocin signaling pathway_Homo sapiens_hsa049210.70411541
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69479089
76Propanoate metabolism_Homo sapiens_hsa006400.69182941
77Cardiac muscle contraction_Homo sapiens_hsa042600.68845068
78Galactose metabolism_Homo sapiens_hsa000520.67033505
79Herpes simplex infection_Homo sapiens_hsa051680.66899098
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66434028
81Pentose phosphate pathway_Homo sapiens_hsa000300.65415911
82Estrogen signaling pathway_Homo sapiens_hsa049150.64796509
83Thyroid cancer_Homo sapiens_hsa052160.64335207
84Basal cell carcinoma_Homo sapiens_hsa052170.63158301
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61195212
86Gastric acid secretion_Homo sapiens_hsa049710.60010308
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59727451
88Chronic myeloid leukemia_Homo sapiens_hsa052200.59506427
89Renin secretion_Homo sapiens_hsa049240.59160947
90Protein export_Homo sapiens_hsa030600.58747006
91RNA degradation_Homo sapiens_hsa030180.58338473
92Hippo signaling pathway_Homo sapiens_hsa043900.58207700
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57631795
94Olfactory transduction_Homo sapiens_hsa047400.57587986
95One carbon pool by folate_Homo sapiens_hsa006700.57222524
96HTLV-I infection_Homo sapiens_hsa051660.56437045
97AMPK signaling pathway_Homo sapiens_hsa041520.56172966
98mTOR signaling pathway_Homo sapiens_hsa041500.56105338
99Melanogenesis_Homo sapiens_hsa049160.56001505
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55460402
101Bladder cancer_Homo sapiens_hsa052190.55184834
102Vitamin B6 metabolism_Homo sapiens_hsa007500.55117240
103GnRH signaling pathway_Homo sapiens_hsa049120.55009582
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54956569
105Apoptosis_Homo sapiens_hsa042100.53899819
106VEGF signaling pathway_Homo sapiens_hsa043700.53355516
107Morphine addiction_Homo sapiens_hsa050320.53345017
108Non-small cell lung cancer_Homo sapiens_hsa052230.53295987
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52799714
110Wnt signaling pathway_Homo sapiens_hsa043100.52576392
111Selenocompound metabolism_Homo sapiens_hsa004500.51005447
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50440768
113Epstein-Barr virus infection_Homo sapiens_hsa051690.50313887
114* Viral carcinogenesis_Homo sapiens_hsa052030.48343606
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47182009
116Insulin secretion_Homo sapiens_hsa049110.46587567
117Legionellosis_Homo sapiens_hsa051340.45992668
118Cholinergic synapse_Homo sapiens_hsa047250.45520758
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.45492899
120Arginine and proline metabolism_Homo sapiens_hsa003300.44893853
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.44554400
122Fatty acid metabolism_Homo sapiens_hsa012120.44105723
123Metabolic pathways_Homo sapiens_hsa011000.43482719
124Glutamatergic synapse_Homo sapiens_hsa047240.43017349
125Long-term depression_Homo sapiens_hsa047300.42461603
126Hedgehog signaling pathway_Homo sapiens_hsa043400.42410065
127Purine metabolism_Homo sapiens_hsa002300.42079942
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40775069
129Lysine degradation_Homo sapiens_hsa003100.40133283
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37066251
131Acute myeloid leukemia_Homo sapiens_hsa052210.35775384
132Pancreatic cancer_Homo sapiens_hsa052120.35314802
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.35261542
134Adherens junction_Homo sapiens_hsa045200.32116876
135Primary immunodeficiency_Homo sapiens_hsa053400.30887579
136Salmonella infection_Homo sapiens_hsa051320.30447274
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29764053
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24172141
139HIF-1 signaling pathway_Homo sapiens_hsa040660.22932180
140Hepatitis B_Homo sapiens_hsa051610.22748892
141Small cell lung cancer_Homo sapiens_hsa052220.22231413
142Lysosome_Homo sapiens_hsa041420.21297254
143MicroRNAs in cancer_Homo sapiens_hsa052060.19913484
144Antigen processing and presentation_Homo sapiens_hsa046120.16899947
145Endometrial cancer_Homo sapiens_hsa052130.15648400
146Measles_Homo sapiens_hsa051620.14707446
147Viral myocarditis_Homo sapiens_hsa054160.14348946

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