HDAC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.93814487
2ribosomal small subunit assembly (GO:0000028)4.66910959
3DNA deamination (GO:0045006)4.65630882
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41372406
5negative regulation of cell killing (GO:0031342)4.41372406
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.28457742
7lymphoid progenitor cell differentiation (GO:0002320)4.25933025
8definitive hemopoiesis (GO:0060216)4.19311764
9platelet dense granule organization (GO:0060155)4.11546792
10regulation of gamma-delta T cell activation (GO:0046643)3.88646862
11cellular extravasation (GO:0045123)3.83805034
12regulation of gamma-delta T cell differentiation (GO:0045586)3.82513837
13positive regulation of granulocyte differentiation (GO:0030854)3.78364545
14daunorubicin metabolic process (GO:0044597)3.65050233
15polyketide metabolic process (GO:0030638)3.65050233
16doxorubicin metabolic process (GO:0044598)3.65050233
17modulation by symbiont of host defense response (GO:0052031)3.59513217
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59513217
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59513217
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.59513217
21modulation by symbiont of host immune response (GO:0052553)3.59513217
22positive regulation by symbiont of host defense response (GO:0052509)3.59513217
23facial nerve structural organization (GO:0021612)3.56546367
24negative regulation of erythrocyte differentiation (GO:0045647)3.56310245
25detection of molecule of bacterial origin (GO:0032490)3.43617689
26positive T cell selection (GO:0043368)3.41201837
27detection of other organism (GO:0098543)3.40008851
28macrophage activation involved in immune response (GO:0002281)3.37475319
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33001994
30telomere maintenance via semi-conservative replication (GO:0032201)3.30244159
31response to muramyl dipeptide (GO:0032495)3.26814922
32leukocyte aggregation (GO:0070486)3.24633910
33negative T cell selection (GO:0043383)3.24238354
34regulation of pigment cell differentiation (GO:0050932)3.24143873
35microglial cell activation (GO:0001774)3.20757466
36activated T cell proliferation (GO:0050798)3.20651915
37histone H3-K36 demethylation (GO:0070544)3.20489348
38phospholipid scrambling (GO:0017121)3.19752738
39negative thymic T cell selection (GO:0045060)3.18325214
40positive thymic T cell selection (GO:0045059)3.17067253
41response to interferon-beta (GO:0035456)3.14803934
42regulation of B cell receptor signaling pathway (GO:0050855)3.10001410
43L-fucose catabolic process (GO:0042355)3.09849016
44fucose catabolic process (GO:0019317)3.09849016
45L-fucose metabolic process (GO:0042354)3.09849016
46detection of external biotic stimulus (GO:0098581)3.09516411
47postsynaptic membrane organization (GO:0001941)3.08814982
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.07439628
49detection of bacterium (GO:0016045)3.07070113
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.06973274
51defense response to protozoan (GO:0042832)3.06389247
52response to interleukin-15 (GO:0070672)3.05446891
53cellular response to epinephrine stimulus (GO:0071872)3.03365767
54secretory granule organization (GO:0033363)3.01931656
55positive regulation of B cell differentiation (GO:0045579)3.01820741
56regulation of somitogenesis (GO:0014807)2.96932395
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94844042
58neutrophil mediated immunity (GO:0002446)2.93949828
59macrophage activation (GO:0042116)2.90909521
60antigen processing and presentation of endogenous antigen (GO:0019883)2.87751791
61T cell selection (GO:0045058)2.86791598
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86661867
63interferon-gamma production (GO:0032609)2.85787126
64negative regulation of T cell mediated immunity (GO:0002710)2.83387394
65antigen processing and presentation via MHC class Ib (GO:0002475)2.83235616
66mannosylation (GO:0097502)2.82601347
67respiratory chain complex IV assembly (GO:0008535)2.82506834
68mucosal-associated lymphoid tissue development (GO:0048537)2.82161595
69Peyers patch development (GO:0048541)2.82161595
70regulation of B cell differentiation (GO:0045577)2.82052933
71telomere maintenance via recombination (GO:0000722)2.81476118
72regulation of ARF protein signal transduction (GO:0032012)2.81366559
73regulation of T cell mediated cytotoxicity (GO:0001914)2.80121345
74tRNA methylation (GO:0030488)2.80053905
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79582166
76sarcoplasmic reticulum calcium ion transport (GO:0070296)2.78964969
77negative regulation of leukocyte mediated immunity (GO:0002704)2.78765460
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77880792
79maturation of 5.8S rRNA (GO:0000460)2.77103040
80cell differentiation involved in metanephros development (GO:0072202)2.74890691
81response to interferon-alpha (GO:0035455)2.74680546
82myeloid leukocyte mediated immunity (GO:0002444)2.74504823
83endosome to melanosome transport (GO:0035646)2.74495001
84endosome to pigment granule transport (GO:0043485)2.74495001
85detection of biotic stimulus (GO:0009595)2.74389114
86response to peptidoglycan (GO:0032494)2.74027499
87leukocyte migration involved in inflammatory response (GO:0002523)2.73742058
88cranial nerve structural organization (GO:0021604)2.72360024
89negative regulation of cAMP-mediated signaling (GO:0043951)2.70911788
90developmental pigmentation (GO:0048066)2.70323891
91response to protozoan (GO:0001562)2.70011434
92mast cell activation (GO:0045576)2.69525915
93energy homeostasis (GO:0097009)2.67901124
94immunoglobulin mediated immune response (GO:0016064)2.67715917
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64028719
96CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.63362445
97purine-containing compound salvage (GO:0043101)2.60301262
98thymic T cell selection (GO:0045061)2.57082179
99neutrophil activation involved in immune response (GO:0002283)2.56792335
100cytochrome complex assembly (GO:0017004)2.56505406
101regulation of T cell receptor signaling pathway (GO:0050856)2.56476875
102response to epinephrine (GO:0071871)2.56475659
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.55931857
104viral transcription (GO:0019083)2.55302696
105cellular response to interferon-beta (GO:0035458)2.54435053
106regulation of developmental pigmentation (GO:0048070)2.54408846
107sympathetic nervous system development (GO:0048485)2.51069964
108cellular response to interleukin-15 (GO:0071350)2.50069778
109positive regulation of gamma-delta T cell activation (GO:0046645)2.49776447
110maturation of SSU-rRNA (GO:0030490)2.49724169
111mitochondrial DNA replication (GO:0006264)2.49548015
112mitotic recombination (GO:0006312)2.46530493
113pseudouridine synthesis (GO:0001522)2.46349866
114regulation of necroptotic process (GO:0060544)2.45889204
115phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.45878697
116negative regulation of glial cell proliferation (GO:0060253)2.45270973
117positive regulation of developmental pigmentation (GO:0048087)2.44686277
118ribosomal small subunit biogenesis (GO:0042274)2.43945870
119generation of neurons (GO:0048699)2.43899454
120negative regulation of type 2 immune response (GO:0002829)2.43189684
121B cell receptor signaling pathway (GO:0050853)2.42433881
122translational termination (GO:0006415)2.41027167
123response to host immune response (GO:0052572)2.39599863
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39599863
125DNA strand elongation (GO:0022616)2.39105582
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38293227
127T cell homeostasis (GO:0043029)2.38238174
128regulation of ARF GTPase activity (GO:0032312)2.38027023
129mesenchymal-epithelial cell signaling (GO:0060638)2.36581416
130telomere maintenance via telomere lengthening (GO:0010833)2.36134730
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36081957
132tolerance induction (GO:0002507)2.36025264
133embryonic hemopoiesis (GO:0035162)2.35758304
134negative regulation of interleukin-12 production (GO:0032695)2.34851515
135myeloid cell activation involved in immune response (GO:0002275)2.33657224
136viral genome replication (GO:0019079)2.33222205
137cranial nerve morphogenesis (GO:0021602)2.32966899
138DNA strand elongation involved in DNA replication (GO:0006271)2.32820501
139mast cell activation involved in immune response (GO:0002279)2.32074965
140mast cell degranulation (GO:0043303)2.32074965
141muscle filament sliding (GO:0030049)2.31449443
142actin-myosin filament sliding (GO:0033275)2.31449443
143regulation of respiratory system process (GO:0044065)2.29813673
144regulation of granulocyte differentiation (GO:0030852)2.29803800
145regulation of mitochondrial translation (GO:0070129)2.29206935
146mature B cell differentiation involved in immune response (GO:0002313)2.29164910
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.29096181
148negative regulation of inclusion body assembly (GO:0090084)2.28894191
149regulation of relaxation of muscle (GO:1901077)2.28704356
150cellular response to ethanol (GO:0071361)2.28418762
151T cell migration (GO:0072678)2.28295656
152regulation of leukocyte degranulation (GO:0043300)2.27706766
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.27587927
154response to host (GO:0075136)2.26884065
155response to host defenses (GO:0052200)2.26884065
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26884065
157negative regulation of viral genome replication (GO:0045071)2.26012754
158interkinetic nuclear migration (GO:0022027)2.25179908
159myofibril assembly (GO:0030239)2.25123906
160neutrophil activation (GO:0042119)2.24311778
161positive regulation of Rap GTPase activity (GO:0032854)2.24213336
162regulation of regulatory T cell differentiation (GO:0045589)2.23721852
163regulation of germinal center formation (GO:0002634)2.22954820
164T cell lineage commitment (GO:0002360)2.22585333
165presynaptic membrane assembly (GO:0097105)2.22508096
166growth hormone receptor signaling pathway (GO:0060396)2.21899996
167negative regulation of immunoglobulin mediated immune response (GO:0002890)2.20471082
168negative regulation of B cell mediated immunity (GO:0002713)2.20471082
169skeletal muscle adaptation (GO:0043501)2.20134925
170granulocyte differentiation (GO:0030851)2.19689588
171histone lysine demethylation (GO:0070076)2.18605543
172cotranslational protein targeting to membrane (GO:0006613)2.17983184
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.17775238
174nucleus localization (GO:0051647)2.17407324
175positive regulation of CREB transcription factor activity (GO:0032793)2.17342662
176positive regulation of defense response to virus by host (GO:0002230)2.17131991
177histone H3-K9 demethylation (GO:0033169)2.16139908
178C-terminal protein lipidation (GO:0006501)2.16121481
179histone H2A acetylation (GO:0043968)2.15994165
180DNA ligation (GO:0006266)2.15849342
181fucosylation (GO:0036065)2.15528414
182DNA replication initiation (GO:0006270)2.15093136
183histone mRNA metabolic process (GO:0008334)2.14914900
184skeletal muscle contraction (GO:0003009)2.14832356
185response to UV-B (GO:0010224)2.14633627
186positive regulation of macrophage differentiation (GO:0045651)2.13117540
187protein targeting to ER (GO:0045047)2.13012339
188sleep (GO:0030431)2.12158201
189histone H3-K4 trimethylation (GO:0080182)2.12092233
190germinal center formation (GO:0002467)2.09819606
191deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.09699659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.94430579
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.82050118
3SCL_19346495_ChIP-Seq_HPC-7_Human3.56115855
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.42946673
5EZH2_22144423_ChIP-Seq_EOC_Human3.11116740
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06522692
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.05099651
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.85137972
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73126727
10FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.68304348
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.67363917
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63968317
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61425481
14DROSHA_22980978_ChIP-Seq_HELA_Human2.61190839
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54861466
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.48725751
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43933686
18GBX2_23144817_ChIP-Seq_PC3_Human2.32218138
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30837178
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30609254
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30197542
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14356418
23IGF1R_20145208_ChIP-Seq_DFB_Human2.11634434
24KDM2B_26808549_Chip-Seq_DND41_Human2.05679469
25TCF7_22412390_ChIP-Seq_EML_Mouse2.03978465
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02794718
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02357579
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95649276
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94123300
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90223679
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89813139
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89672624
33* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87472024
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85354212
35* RUNX_20019798_ChIP-Seq_JUKART_Human1.80149254
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79261293
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79168167
38IRF1_19129219_ChIP-ChIP_H3396_Human1.78896367
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75328544
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73402581
41GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.73149037
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72125837
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69350690
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.69104502
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65429503
46SPI1_23547873_ChIP-Seq_NB4_Human1.63797829
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63673534
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.63115006
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61722856
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61550994
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60539506
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57843484
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57270679
54* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55767393
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.52385194
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52090234
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51386766
58KDM2B_26808549_Chip-Seq_K562_Human1.50107917
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48724971
60* VDR_24787735_ChIP-Seq_THP-1_Human1.48683369
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.47728279
62FOXP3_21729870_ChIP-Seq_TREG_Human1.46619707
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46092548
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45973238
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.44344055
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43377969
67VDR_23849224_ChIP-Seq_CD4+_Human1.41488968
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40190635
69* UTX_26944678_Chip-Seq_JUKART_Human1.38001915
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35849522
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35257745
72* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34029525
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32716019
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32016863
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.31028400
76AR_21572438_ChIP-Seq_LNCaP_Human1.30304491
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29081125
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.28726306
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.27910402
80VDR_24763502_ChIP-Seq_THP-1_Human1.27881486
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22933316
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22911650
83* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20589030
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20359700
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20295026
86MYB_26560356_Chip-Seq_TH2_Human1.19512217
87FUS_26573619_Chip-Seq_HEK293_Human1.19203227
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17810491
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17788662
90GATA3_27048872_Chip-Seq_THYMUS_Human1.17502672
91* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16993299
92* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16922991
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15741304
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.15527809
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.15499811
96GATA1_22025678_ChIP-Seq_K562_Human1.13030200
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.12724181
98* VDR_21846776_ChIP-Seq_THP-1_Human1.12320365
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11997847
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11758756
101ELK1_19687146_ChIP-ChIP_HELA_Human1.11372406
102EWS_26573619_Chip-Seq_HEK293_Human1.11363123
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09547509
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09483973
105* CIITA_25753668_ChIP-Seq_RAJI_Human1.08196951
106* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07822108
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07601994
108MYB_26560356_Chip-Seq_TH1_Human1.06639305
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06486174
110* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05811621
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02896994
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02669175
113* MAF_26560356_Chip-Seq_TH2_Human1.02622008
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02394625
115GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01843830
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01605175
117LXR_22292898_ChIP-Seq_THP-1_Human1.01587430
118GATA1_19941826_ChIP-Seq_K562_Human1.01509410
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.00256712
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99374768
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98725584
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98689329
123MYC_18940864_ChIP-ChIP_HL60_Human0.98649721
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98597150
125GABP_17652178_ChIP-ChIP_JURKAT_Human0.98429986
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98189198
127* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98136654
128TAF15_26573619_Chip-Seq_HEK293_Human0.97803584
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97601920
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97303199
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95592370
132GATA2_19941826_ChIP-Seq_K562_Human0.94866365
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94724870
134* NFE2_27457419_Chip-Seq_LIVER_Mouse0.94250482
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.92243337
136* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91748313
137SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91445820
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90481344
139MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90447257
140SMC4_20622854_ChIP-Seq_HELA_Human0.90321461
141* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88488035
142P300_19829295_ChIP-Seq_ESCs_Human0.87702561
143* REST_21632747_ChIP-Seq_MESCs_Mouse0.87024284
144* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86877211
145EZH2_27294783_Chip-Seq_ESCs_Mouse0.86719857
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86410259
147* SPI1_23127762_ChIP-Seq_K562_Human0.86015474
148* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85747565
149* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85747565
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85452238
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.84986525
152SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84986072
153OCT4_19829295_ChIP-Seq_ESCs_Human0.84775045
154* PU_27001747_Chip-Seq_BMDM_Mouse0.83880095
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83611794
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83274617
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82910593
158IRF8_21731497_ChIP-ChIP_J774_Mouse0.82892369
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82591537
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82399059
161KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81723810
162ETS1_20019798_ChIP-Seq_JURKAT_Human0.81273714
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81158384
164KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80958537
165* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80543067
166* AR_19668381_ChIP-Seq_PC3_Human0.80099185
167MYC_22102868_ChIP-Seq_BL_Human0.79861671
168GATA2_21666600_ChIP-Seq_HMVEC_Human0.78175053
169PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77192194
170GATA1_19941827_ChIP-Seq_MEL_Mouse0.77035797
171* MAF_26560356_Chip-Seq_TH1_Human0.75950426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.24517442
2MP0001188_hyperpigmentation3.46254398
3MP0000015_abnormal_ear_pigmentation3.32416562
4MP0005075_abnormal_melanosome_morpholog3.25228307
5MP0004130_abnormal_muscle_cell3.23779426
6MP0005174_abnormal_tail_pigmentation3.11919999
7MP0005451_abnormal_body_composition3.04210788
8MP0002396_abnormal_hematopoietic_system3.00884553
9MP0003646_muscle_fatigue2.82206985
10MP0005409_darkened_coat_color2.78189763
11MP0009379_abnormal_foot_pigmentation2.45741713
12MP0000569_abnormal_digit_pigmentation2.41023547
13MP0002095_abnormal_skin_pigmentation2.34537075
14MP0003763_abnormal_thymus_physiology2.34234369
15MP0001986_abnormal_taste_sensitivity2.27057022
16MP0009278_abnormal_bone_marrow2.27029030
17MP0005671_abnormal_response_to2.20157064
18MP0003690_abnormal_glial_cell2.16976395
19MP0003303_peritoneal_inflammation2.10263891
20MP0000372_irregular_coat_pigmentation2.05905068
21MP0004808_abnormal_hematopoietic_stem1.99616958
22MP0001835_abnormal_antigen_presentation1.98675342
23MP0003172_abnormal_lysosome_physiology1.93710616
24MP0000749_muscle_degeneration1.90322604
25MP0009785_altered_susceptibility_to1.85493082
26MP0002332_abnormal_exercise_endurance1.82045128
27MP0008058_abnormal_DNA_repair1.81536227
28MP0000751_myopathy1.80179494
29MP0005076_abnormal_cell_differentiation1.73965945
30MP0004510_myositis1.69945364
31MP0005397_hematopoietic_system_phenotyp1.69819748
32MP0001545_abnormal_hematopoietic_system1.69819748
33MP0004036_abnormal_muscle_relaxation1.69555710
34MP0000685_abnormal_immune_system1.67921906
35MP0003300_gastrointestinal_ulcer1.65009857
36MP0004381_abnormal_hair_follicle1.63864158
37MP0000747_muscle_weakness1.58050871
38MP0008260_abnormal_autophagy1.57139478
39MP0003136_yellow_coat_color1.55060330
40MP0008007_abnormal_cellular_replicative1.54130019
41MP0003724_increased_susceptibility_to1.53700956
42MP0002398_abnormal_bone_marrow1.53308196
43MP0002106_abnormal_muscle_physiology1.48921756
44MP0001873_stomach_inflammation1.44404236
45MP0004087_abnormal_muscle_fiber1.42239629
46MP0000049_abnormal_middle_ear1.41161367
47MP0000490_abnormal_crypts_of1.40656855
48MP0004147_increased_porphyrin_level1.40164329
49MP0002420_abnormal_adaptive_immunity1.38868506
50MP0005025_abnormal_response_to1.37164831
51MP0000678_abnormal_parathyroid_gland1.35233678
52MP0002751_abnormal_autonomic_nervous1.35038100
53MP0003880_abnormal_central_pattern1.34798758
54MP0001819_abnormal_immune_cell1.33821114
55MP0003045_fibrosis1.33756250
56MP0004484_altered_response_of1.33464880
57* MP0000759_abnormal_skeletal_muscle1.32444385
58MP0004947_skin_inflammation1.30869441
59MP0002938_white_spotting1.30349320
60MP0002177_abnormal_outer_ear1.29442113
61MP0002132_abnormal_respiratory_system1.29308604
62MP0003329_amyloid_beta_deposits1.22548438
63MP0002102_abnormal_ear_morphology1.22470752
64MP0005394_taste/olfaction_phenotype1.22026118
65MP0005499_abnormal_olfactory_system1.22026118
66MP0000703_abnormal_thymus_morphology1.21920020
67MP0002723_abnormal_immune_serum1.20612137
68MP0000716_abnormal_immune_system1.20479608
69MP0001851_eye_inflammation1.20395962
70MP0001968_abnormal_touch/_nociception1.18789166
71MP0002148_abnormal_hypersensitivity_rea1.18347647
72MP0002452_abnormal_antigen_presenting1.18218517
73MP0001800_abnormal_humoral_immune1.17855119
74MP0000465_gastrointestinal_hemorrhage1.17799446
75MP0000566_synostosis1.17608536
76MP0005369_muscle_phenotype1.17378446
77MP0004270_analgesia1.15682579
78MP0002998_abnormal_bone_remodeling1.15445816
79MP0002006_tumorigenesis1.14597727
80MP0003866_abnormal_defecation1.14126655
81MP0008789_abnormal_olfactory_epithelium1.14120675
82MP0000681_abnormal_thyroid_gland1.13595833
83MP0001853_heart_inflammation1.12484393
84MP0005000_abnormal_immune_tolerance1.12341691
85MP0001533_abnormal_skeleton_physiology1.11167096
86MP0003787_abnormal_imprinting1.09153881
87MP0002722_abnormal_immune_system1.09123804
88MP0002735_abnormal_chemical_nociception1.08700429
89MP0001501_abnormal_sleep_pattern1.08260387
90MP0005646_abnormal_pituitary_gland1.07642700
91MP0000689_abnormal_spleen_morphology1.07498256
92MP0002166_altered_tumor_susceptibility1.06997279
93MP0005423_abnormal_somatic_nervous1.06367850
94MP0000750_abnormal_muscle_regeneration1.06302014
95MP0002429_abnormal_blood_cell1.05533838
96MP0002269_muscular_atrophy1.04511188
97MP0000733_abnormal_muscle_development1.04486796
98MP0001486_abnormal_startle_reflex1.04352251
99MP0002419_abnormal_innate_immunity1.03480387
100MP0010094_abnormal_chromosome_stability1.03206865
101MP0003656_abnormal_erythrocyte_physiolo1.02103134
102MP0003693_abnormal_embryo_hatching1.00955744
103MP0003183_abnormal_peptide_metabolism0.99418922
104MP0002249_abnormal_larynx_morphology0.99374847
105MP0002063_abnormal_learning/memory/cond0.98953670
106MP0002075_abnormal_coat/hair_pigmentati0.98117247
107MP0002822_catalepsy0.95403970
108* MP0002064_seizures0.95079560
109MP0002638_abnormal_pupillary_reflex0.94745805
110MP0002971_abnormal_brown_adipose0.94730059
111MP0005666_abnormal_adipose_tissue0.94583928
112MP0005620_abnormal_muscle_contractility0.94183024
113MP0004233_abnormal_muscle_weight0.93468697
114MP0009115_abnormal_fat_cell0.93440839
115MP0004883_abnormal_blood_vessel0.92641201
116MP0010630_abnormal_cardiac_muscle0.92040459
117MP0005387_immune_system_phenotype0.91955678
118MP0001790_abnormal_immune_system0.91955678
119MP0002736_abnormal_nociception_after0.91222185
120MP0008569_lethality_at_weaning0.90970953
121MP0000371_diluted_coat_color0.88641261
122MP0006082_CNS_inflammation0.88149265
123MP0002405_respiratory_system_inflammati0.87452410
124MP0003436_decreased_susceptibility_to0.87252663
125MP0005167_abnormal_blood-brain_barrier0.86536909
126MP0000631_abnormal_neuroendocrine_gland0.84915741
127MP0000920_abnormal_myelination0.82375611
128MP0009333_abnormal_splenocyte_physiolog0.81272695
129MP0006138_congestive_heart_failure0.80746916
130MP0004145_abnormal_muscle_electrophysio0.80368874
131MP0001186_pigmentation_phenotype0.80249008
132MP0003943_abnormal_hepatobiliary_system0.79326608
133MP0003786_premature_aging0.79102661
134MP0004142_abnormal_muscle_tone0.78309709
135MP0010155_abnormal_intestine_physiology0.77292631
136MP0003705_abnormal_hypodermis_morpholog0.76283335
137MP0000604_amyloidosis0.76184695
138MP0003879_abnormal_hair_cell0.75301271
139MP0002108_abnormal_muscle_morphology0.75203835
140MP0004185_abnormal_adipocyte_glucose0.75056523
141MP0003091_abnormal_cell_migration0.74590130
142MP0005377_hearing/vestibular/ear_phenot0.74394657
143MP0005464_abnormal_platelet_physiology0.73100752
144MP0000858_altered_metastatic_potential0.68988740
145MP0003635_abnormal_synaptic_transmissio0.68937315
146MP0001984_abnormal_olfaction0.67768120
147MP0002557_abnormal_social/conspecific_i0.66793893
148MP0002933_joint_inflammation0.62606044
149MP0003828_pulmonary_edema0.62362130
150MP0002009_preneoplasia0.60964814
151MP0001663_abnormal_digestive_system0.60726887
152MP0001270_distended_abdomen0.58630000
153MP0003938_abnormal_ear_development0.57587843
154MP0002272_abnormal_nervous_system0.56455305
155MP0005171_absent_coat_pigmentation0.55955818
156MP0002089_abnormal_postnatal_growth/wei0.55951280
157MP0004859_abnormal_synaptic_plasticity0.55717918

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.01756951
2Nemaline bodies (HP:0003798)4.76333887
3Muscle fiber inclusion bodies (HP:0100299)4.70188217
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.57984717
5Type I transferrin isoform profile (HP:0003642)4.35082348
6Difficulty running (HP:0009046)4.16379274
7Hypothermia (HP:0002045)4.08711301
8Exercise-induced myalgia (HP:0003738)4.00555077
9Type 1 muscle fiber predominance (HP:0003803)3.62250789
10Hyporeflexia of lower limbs (HP:0002600)3.43668967
11Myositis (HP:0100614)3.31137673
12Type 2 muscle fiber atrophy (HP:0003554)3.25194102
13Muscle fiber splitting (HP:0003555)3.24911070
14Elevated erythrocyte sedimentation rate (HP:0003565)3.22273031
15Recurrent bacterial skin infections (HP:0005406)3.10986593
16Thrombocytosis (HP:0001894)3.00527681
17Muscle fiber atrophy (HP:0100295)2.93145989
18Abnormal protein glycosylation (HP:0012346)2.90510177
19Abnormal glycosylation (HP:0012345)2.90510177
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.90510177
21Abnormal protein N-linked glycosylation (HP:0012347)2.90510177
22Increased IgE level (HP:0003212)2.89566418
23Nonprogressive disorder (HP:0003680)2.88310361
24Abnormality of skeletal muscle fiber size (HP:0012084)2.78644822
25Reduced antithrombin III activity (HP:0001976)2.77215756
26Increased variability in muscle fiber diameter (HP:0003557)2.76223191
27Obstructive sleep apnea (HP:0002870)2.74710822
28Severe visual impairment (HP:0001141)2.72075292
29EMG: myopathic abnormalities (HP:0003458)2.67462226
30IgM deficiency (HP:0002850)2.66261761
31Hemiplegia (HP:0002301)2.65819086
32Myopathic facies (HP:0002058)2.59242662
33Gastrointestinal infarctions (HP:0005244)2.59208546
34Spontaneous hematomas (HP:0007420)2.56550645
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56274208
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56246203
37Genetic anticipation (HP:0003743)2.54148646
38Recurrent gram-negative bacterial infections (HP:0005420)2.51524806
39Gingivitis (HP:0000230)2.51413158
40Increased connective tissue (HP:0009025)2.50009840
41Distal arthrogryposis (HP:0005684)2.49832002
42Prolonged bleeding time (HP:0003010)2.48128611
43Acute lymphatic leukemia (HP:0006721)2.47124544
44Diplopia (HP:0000651)2.47094407
45Abnormality of binocular vision (HP:0011514)2.47094407
46Frequent falls (HP:0002359)2.44832395
47Abnormal number of erythroid precursors (HP:0012131)2.41074300
48Hyperkalemia (HP:0002153)2.40754820
49T lymphocytopenia (HP:0005403)2.39760599
50Clubbing of toes (HP:0100760)2.39587077
51Exercise-induced muscle cramps (HP:0003710)2.39534982
52Ulnar deviation of the wrist (HP:0003049)2.38572357
53B lymphocytopenia (HP:0010976)2.34265495
54Abnormality of B cell number (HP:0010975)2.34265495
55Muscle hypertrophy of the lower extremities (HP:0008968)2.34232750
56Nasolacrimal duct obstruction (HP:0000579)2.33570572
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.33420571
58Slow saccadic eye movements (HP:0000514)2.32290270
59Median cleft lip (HP:0000161)2.32247287
60Chronic otitis media (HP:0000389)2.32126290
61Chromsome breakage (HP:0040012)2.29879427
62EMG: neuropathic changes (HP:0003445)2.28173300
63Reticulocytopenia (HP:0001896)2.25353420
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24928341
65Abnormal hair whorl (HP:0010721)2.24057666
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.23960699
67Petechiae (HP:0000967)2.23370625
68Chest pain (HP:0100749)2.22830346
69Recurrent abscess formation (HP:0002722)2.22726195
70Abnormality of DNA repair (HP:0003254)2.22267798
71Postural instability (HP:0002172)2.21037995
72Abnormality of cells of the erythroid lineage (HP:0012130)2.20779519
73Dry hair (HP:0011359)2.15546371
74Recurrent skin infections (HP:0001581)2.15340206
75Intestinal fistula (HP:0100819)2.14396842
76Abnormality of macrophages (HP:0004311)2.14085774
77Asymmetric septal hypertrophy (HP:0001670)2.12956550
78Panhypogammaglobulinemia (HP:0003139)2.12798771
79Mediastinal lymphadenopathy (HP:0100721)2.12578394
80Calf muscle hypertrophy (HP:0008981)2.11978147
81True hermaphroditism (HP:0010459)2.11382507
82Myelodysplasia (HP:0002863)2.09766521
83Optic nerve coloboma (HP:0000588)2.06354823
84Areflexia of lower limbs (HP:0002522)2.04697798
85Keratoconjunctivitis sicca (HP:0001097)2.04120265
86Hypoplasia of the thymus (HP:0000778)2.04044449
87Hypoproteinemia (HP:0003075)2.02352752
88Febrile seizures (HP:0002373)2.02310926
89* Subaortic stenosis (HP:0001682)2.02267522
90* Abnormality of the left ventricular outflow tract (HP:0011103)2.02267522
91Abnormality of T cell number (HP:0011839)2.01977470
92Meckel diverticulum (HP:0002245)2.01724110
93Abnormal number of incisors (HP:0011064)2.00934047
94Papilledema (HP:0001085)2.00129557
95Abnormality of the ileum (HP:0001549)1.99879883
96Acute myeloid leukemia (HP:0004808)1.99642054
97Round ear (HP:0100830)1.99232806
98Recurrent cutaneous fungal infections (HP:0011370)1.96607923
99Chronic mucocutaneous candidiasis (HP:0002728)1.96607923
100Leukocytosis (HP:0001974)1.96424785
101Abnormality of the parietal bone (HP:0002696)1.95297384
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.95228318
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94560990
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94560990
105Patchy hypopigmentation of hair (HP:0011365)1.94008097
106Pancreatic fibrosis (HP:0100732)1.93539152
107Fetal akinesia sequence (HP:0001989)1.93330786
108Abnormality of the lacrimal duct (HP:0011481)1.92832181
109Lip pit (HP:0100267)1.91983228
110Microvesicular hepatic steatosis (HP:0001414)1.91551315
111Abnormality of the preputium (HP:0100587)1.90585380
112Meningitis (HP:0001287)1.90174157
113Progressive cerebellar ataxia (HP:0002073)1.90088010
114Dysmetric saccades (HP:0000641)1.89440765
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.89027378
116Hepatocellular necrosis (HP:0001404)1.88916301
117Thyroid-stimulating hormone excess (HP:0002925)1.88605238
118Pancytopenia (HP:0001876)1.88393347
119* Abnormality of the columella (HP:0009929)1.87933056
120Blue irides (HP:0000635)1.87369644
121Peritonitis (HP:0002586)1.87332938
122Cerebral aneurysm (HP:0004944)1.86897833
123Protruding tongue (HP:0010808)1.86815315
124Abnormality of the nasal septum (HP:0000419)1.85086821
125Granulocytopenia (HP:0001913)1.85005660
126Agammaglobulinemia (HP:0004432)1.84632156
127Abnormality of the nasolacrimal system (HP:0000614)1.84518519
128Eczematoid dermatitis (HP:0000976)1.84048394
129Truncal obesity (HP:0001956)1.84009692
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83798235
131White forelock (HP:0002211)1.83511755
132Keratoconjunctivitis (HP:0001096)1.83107270
133Eosinophilia (HP:0001880)1.82925668
134Cellulitis (HP:0100658)1.82003461
135Poikiloderma (HP:0001029)1.81071204
136Neoplasm of the heart (HP:0100544)1.80820422
137Obstructive lung disease (HP:0006536)1.80515853
138Chronic obstructive pulmonary disease (HP:0006510)1.80515853
139Pallor (HP:0000980)1.79775369
140Lymphoma (HP:0002665)1.78346111
141Abnormality of the endocardium (HP:0004306)1.77797913
142Abnormality of the right ventricle (HP:0001707)1.77292247
143Onion bulb formation (HP:0003383)1.77253346
144Long clavicles (HP:0000890)1.76776987
145Bowel incontinence (HP:0002607)1.76200489
146Rectal fistula (HP:0100590)1.76000257
147Rectovaginal fistula (HP:0000143)1.76000257
148Preaxial hand polydactyly (HP:0001177)1.74854546
149Optic neuritis (HP:0100653)1.74670747
150Retrobulbar optic neuritis (HP:0100654)1.74670747
151Albinism (HP:0001022)1.74335639
152Abnormal rod and cone electroretinograms (HP:0008323)1.74103762
153Submucous cleft hard palate (HP:0000176)1.74090759
154Subacute progressive viral hepatitis (HP:0006572)1.72806838
155Stomatitis (HP:0010280)1.72191815
156Pancreatic cysts (HP:0001737)1.71938114
157Abnormality of the incisor (HP:0000676)1.71300129
158Supernumerary ribs (HP:0005815)1.70587765
159Microretrognathia (HP:0000308)1.69207725
160Severe combined immunodeficiency (HP:0004430)1.68957401
161Foot dorsiflexor weakness (HP:0009027)1.67874996
162Hyperventilation (HP:0002883)1.67851396
163Hypochromic microcytic anemia (HP:0004840)1.67708935
164Abnormality of the fingertips (HP:0001211)1.67570340
165Hemoptysis (HP:0002105)1.67560805
166Ventricular fibrillation (HP:0001663)1.67400817
167Spinal canal stenosis (HP:0003416)1.66923842
1683-Methylglutaconic aciduria (HP:0003535)1.66253739
169Dislocated radial head (HP:0003083)1.65843453
170Episodic fever (HP:0001954)1.65221396
171IgG deficiency (HP:0004315)1.65064897
172Intestinal atresia (HP:0011100)1.63434385
173Abnormality of the carotid arteries (HP:0005344)1.63354978
174Abnormality of chromosome stability (HP:0003220)1.63296952
175Rapidly progressive (HP:0003678)1.63204080
176Orchitis (HP:0100796)1.62819334
177Abnormality of the foot musculature (HP:0001436)1.62693997
178Split foot (HP:0001839)1.62563959
179Recurrent fungal infections (HP:0002841)1.61616372
180Short 4th metacarpal (HP:0010044)1.61320079
181Vaginal fistula (HP:0004320)1.61085735
182Focal motor seizures (HP:0011153)1.60849370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.75343951
2MUSK4.08301195
3CASK3.64683382
4MAP3K122.97377423
5STK162.86823263
6OBSCN2.81234973
7CDK192.76855135
8MKNK22.61328585
9KIT2.37812433
10FLT32.36295254
11BLK2.28432811
12TEC2.24613610
13TXK2.24391859
14CDK122.18066726
15TTN2.05221951
16MAP2K72.03780873
17MKNK11.88714997
18TAOK21.75213481
19ADRBK21.66354447
20NLK1.66328753
21NME21.61875742
22MAPK131.59133464
23ICK1.58970891
24TRIB31.58812894
25MAPK121.57998569
26MAP3K131.54755582
27IRAK41.54717938
28TYK21.49854470
29BTK1.49101934
30KSR21.48309343
31VRK11.47543386
32CAMKK21.46050539
33EPHB11.41397669
34PRPF4B1.40644726
35PIK3CG1.40349878
36* MARK21.39931796
37CAMKK11.39814336
38FGFR31.37173246
39WEE11.36007920
40MAP4K11.35340136
41WNK11.34920036
42FES1.32916509
43PIM21.31524071
44EIF2AK21.30374065
45SGK31.27950600
46* MAP3K71.27812089
47YES11.26993317
48CSF1R1.26916180
49TAOK11.24863107
50CSK1.24403793
51CCNB11.22953184
52ACVR1B1.20632744
53GRK61.20409776
54DAPK11.18512280
55MAP2K41.18447827
56PHKG11.16436514
57PHKG21.16436514
58TGFBR11.16143007
59CAMK1D1.15698047
60SIK21.15522633
61ZAK1.13317571
62JAK21.11807030
63BMPR1B1.11615088
64SGK4941.11251742
65SGK2231.11251742
66RIPK11.11245262
67STK111.05980547
68FGFR41.04953424
69IKBKE1.04154229
70NTRK31.03053957
71JAK11.02929273
72ERN11.02580093
73SIK31.02484149
74MAP3K11.01695623
75CLK11.01212175
76BRSK21.00979362
77CDK81.00939153
78TGFBR20.99051242
79MAP3K20.97240481
80JAK30.95501554
81NTRK20.94223752
82PDK10.92625215
83RET0.92130151
84IKBKB0.91543486
85ZAP700.89534826
86SRPK10.88446024
87SYK0.87222696
88MAP3K30.87121516
89CDK30.87062526
90TNK20.86868542
91TYRO30.86306980
92CAMK1G0.84760656
93STK380.80713204
94DAPK20.79582176
95PRKD20.79559033
96SGK20.78905412
97* CAMK40.78773220
98MAP3K100.78089619
99MAP3K140.76433837
100ITK0.75564716
101RPS6KA60.75366656
102MAPKAPK50.74803187
103HIPK20.74547324
104MARK10.73907289
105PDPK10.73829471
106RPS6KC10.73245032
107RPS6KL10.73245032
108SGK10.73156721
109MAPK70.72221246
110CDC42BPA0.71338793
111MAP2K30.71259975
112* CAMK10.70887132
113TBK10.69354708
114MAPK110.68717937
115FGR0.67525907
116BRD40.66533861
117PRKAA20.65961226
118TLK10.65882517
119LCK0.65577795
120FGFR20.65127168
121PDGFRB0.64336257
122MATK0.63948247
123EIF2AK30.63464643
124MTOR0.62760670
125UHMK10.62128391
126BMPR20.61003479
127RIPK40.60766283
128RPS6KA20.59970978
129LYN0.58908689
130TIE10.58480860
131AKT30.57134913
132PRKD30.57132502
133PRKCH0.56904471
134NUAK10.56487591
135DYRK1B0.55669068
136MYLK0.54614474
137MAPK150.54326855
138RAF10.53955082
139PTK60.52855186
140ATR0.52682382
141MELK0.51839805
142ERBB30.51463349
143TAOK30.50355025
144IRAK10.49681436
145MAPKAPK30.48938509
146GRK70.48355377
147MAPK40.48201402
148IRAK30.47843107
149CDK70.47662693
150TSSK60.47472287
151PIM10.45247489
152RPS6KB20.44859181
153RPS6KB10.43273307
154PINK10.39331796
155MAP2K60.39146922
156RPS6KA40.38382832
157ADRBK10.37674371
158PRKG20.32775631
159GRK10.31529591
160MAP3K110.31399274
161MAP3K60.31349761
162HCK0.31329894
163EPHA30.30850085
164MAPK30.29423533
165EEF2K0.29314390
166GRK50.28606054
167ILK0.28221532

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00541565
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53603700
3Ribosome_Homo sapiens_hsa030102.42272741
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32665474
5Homologous recombination_Homo sapiens_hsa034402.13907556
6Non-homologous end-joining_Homo sapiens_hsa034502.03264587
7Base excision repair_Homo sapiens_hsa034102.01018580
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99311981
9Mismatch repair_Homo sapiens_hsa034301.95770787
10Fanconi anemia pathway_Homo sapiens_hsa034601.94396993
11Primary immunodeficiency_Homo sapiens_hsa053401.85623506
12Non-small cell lung cancer_Homo sapiens_hsa052231.75043408
13Dorso-ventral axis formation_Homo sapiens_hsa043201.65736373
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54371670
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54213669
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51292895
17Pyrimidine metabolism_Homo sapiens_hsa002401.43398492
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43172121
19Endometrial cancer_Homo sapiens_hsa052131.41193606
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36660287
21Nucleotide excision repair_Homo sapiens_hsa034201.35980495
22GnRH signaling pathway_Homo sapiens_hsa049121.35296135
23Measles_Homo sapiens_hsa051621.34979069
24Chronic myeloid leukemia_Homo sapiens_hsa052201.33885135
25RNA polymerase_Homo sapiens_hsa030201.31734167
26Hematopoietic cell lineage_Homo sapiens_hsa046401.31351980
27Herpes simplex infection_Homo sapiens_hsa051681.28545264
28VEGF signaling pathway_Homo sapiens_hsa043701.26943707
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26651689
30Oxytocin signaling pathway_Homo sapiens_hsa049211.25480107
31Leishmaniasis_Homo sapiens_hsa051401.24236400
32RNA degradation_Homo sapiens_hsa030181.24119846
33FoxO signaling pathway_Homo sapiens_hsa040681.23481394
34Glioma_Homo sapiens_hsa052141.23379510
35N-Glycan biosynthesis_Homo sapiens_hsa005101.23262548
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.21751721
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20534580
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.20261179
39mTOR signaling pathway_Homo sapiens_hsa041501.19486118
40Renal cell carcinoma_Homo sapiens_hsa052111.17972501
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16932049
42Type II diabetes mellitus_Homo sapiens_hsa049301.16128174
43Spliceosome_Homo sapiens_hsa030401.15529176
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.15370553
45Pancreatic cancer_Homo sapiens_hsa052121.14911393
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14829022
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14731630
48Purine metabolism_Homo sapiens_hsa002301.12644137
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12532405
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11855423
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11451716
52Inositol phosphate metabolism_Homo sapiens_hsa005621.11269355
53ErbB signaling pathway_Homo sapiens_hsa040121.11168647
54Choline metabolism in cancer_Homo sapiens_hsa052311.10954677
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.10922376
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10696140
57Nicotine addiction_Homo sapiens_hsa050331.10073876
58Gastric acid secretion_Homo sapiens_hsa049711.06944765
59Estrogen signaling pathway_Homo sapiens_hsa049151.06386246
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04958177
61Acute myeloid leukemia_Homo sapiens_hsa052211.04302308
62Allograft rejection_Homo sapiens_hsa053301.03696117
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02928363
64Insulin signaling pathway_Homo sapiens_hsa049101.02618098
65Basal transcription factors_Homo sapiens_hsa030221.00945101
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00440371
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00376057
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.98900473
69MAPK signaling pathway_Homo sapiens_hsa040100.97822297
70Insulin resistance_Homo sapiens_hsa049310.97555758
71B cell receptor signaling pathway_Homo sapiens_hsa046620.95762036
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95504299
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95167825
74Staphylococcus aureus infection_Homo sapiens_hsa051500.94940694
75T cell receptor signaling pathway_Homo sapiens_hsa046600.94687458
76Protein export_Homo sapiens_hsa030600.94379677
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94258926
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94108907
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92886206
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91286624
81Renin secretion_Homo sapiens_hsa049240.87401441
82Long-term depression_Homo sapiens_hsa047300.85143088
83Taste transduction_Homo sapiens_hsa047420.84629668
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83847482
85Prostate cancer_Homo sapiens_hsa052150.83604067
86Circadian entrainment_Homo sapiens_hsa047130.83428203
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.83362087
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.82030892
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81066442
90Calcium signaling pathway_Homo sapiens_hsa040200.78680778
91Phototransduction_Homo sapiens_hsa047440.78100848
92Colorectal cancer_Homo sapiens_hsa052100.77729875
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77515065
94Hepatitis B_Homo sapiens_hsa051610.77063690
95Dilated cardiomyopathy_Homo sapiens_hsa054140.76853924
96Osteoclast differentiation_Homo sapiens_hsa043800.76852890
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74633771
98Cell cycle_Homo sapiens_hsa041100.73022168
99Morphine addiction_Homo sapiens_hsa050320.72793182
100Influenza A_Homo sapiens_hsa051640.72456060
101Olfactory transduction_Homo sapiens_hsa047400.72305915
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.71330422
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70683116
104Salivary secretion_Homo sapiens_hsa049700.70057546
105Glucagon signaling pathway_Homo sapiens_hsa049220.69735250
106Rap1 signaling pathway_Homo sapiens_hsa040150.68688303
107Melanogenesis_Homo sapiens_hsa049160.67456579
108Insulin secretion_Homo sapiens_hsa049110.67333322
109AMPK signaling pathway_Homo sapiens_hsa041520.66576686
110Asthma_Homo sapiens_hsa053100.66551853
111Circadian rhythm_Homo sapiens_hsa047100.65965320
112HIF-1 signaling pathway_Homo sapiens_hsa040660.65381791
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63426452
114Hepatitis C_Homo sapiens_hsa051600.61916345
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61589698
116Notch signaling pathway_Homo sapiens_hsa043300.61493891
117GABAergic synapse_Homo sapiens_hsa047270.61106589
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60911238
119Dopaminergic synapse_Homo sapiens_hsa047280.60783211
120Amoebiasis_Homo sapiens_hsa051460.60029815
121Wnt signaling pathway_Homo sapiens_hsa043100.59577478
122HTLV-I infection_Homo sapiens_hsa051660.59292011
123cAMP signaling pathway_Homo sapiens_hsa040240.59234720
124Antigen processing and presentation_Homo sapiens_hsa046120.58090144
125Rheumatoid arthritis_Homo sapiens_hsa053230.57960709
126p53 signaling pathway_Homo sapiens_hsa041150.57577975
127Ras signaling pathway_Homo sapiens_hsa040140.57191168
128Thyroid cancer_Homo sapiens_hsa052160.57058771
129Long-term potentiation_Homo sapiens_hsa047200.55376668
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.55058409
131TNF signaling pathway_Homo sapiens_hsa046680.54711231
132Other glycan degradation_Homo sapiens_hsa005110.54527709
133Tuberculosis_Homo sapiens_hsa051520.54478777
134* Epstein-Barr virus infection_Homo sapiens_hsa051690.54469537
135Pertussis_Homo sapiens_hsa051330.54271619
136Glutamatergic synapse_Homo sapiens_hsa047240.54156106
137Platelet activation_Homo sapiens_hsa046110.52058659
138Shigellosis_Homo sapiens_hsa051310.51545870
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51361589
140Toxoplasmosis_Homo sapiens_hsa051450.50954877
141* Alcoholism_Homo sapiens_hsa050340.50932290
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50839508
143Salmonella infection_Homo sapiens_hsa051320.50291408
144Systemic lupus erythematosus_Homo sapiens_hsa053220.49777196
145Graft-versus-host disease_Homo sapiens_hsa053320.49195657
146Serotonergic synapse_Homo sapiens_hsa047260.48913952
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48861756
148Type I diabetes mellitus_Homo sapiens_hsa049400.48102587
149African trypanosomiasis_Homo sapiens_hsa051430.46636511
150Amphetamine addiction_Homo sapiens_hsa050310.45996118
151Autoimmune thyroid disease_Homo sapiens_hsa053200.45809536
152Cholinergic synapse_Homo sapiens_hsa047250.45628625
153Malaria_Homo sapiens_hsa051440.44823676
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44651747
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43908630
156Chemokine signaling pathway_Homo sapiens_hsa040620.42875542
157Pathways in cancer_Homo sapiens_hsa052000.40592840
158Prolactin signaling pathway_Homo sapiens_hsa049170.39989399
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39490574

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