HDAC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.88423384
2COPI coating of Golgi vesicle (GO:0048205)5.88423384
3histone H4-K12 acetylation (GO:0043983)5.02619801
4negative regulation of cholesterol transport (GO:0032375)4.99328628
5negative regulation of sterol transport (GO:0032372)4.99328628
6exogenous drug catabolic process (GO:0042738)4.91363567
7regulation of meiosis I (GO:0060631)4.78395785
8drug catabolic process (GO:0042737)4.69981063
9pyrimidine nucleobase catabolic process (GO:0006208)4.63106627
10synapsis (GO:0007129)4.62821614
11male meiosis I (GO:0007141)4.49913062
12sex determination (GO:0007530)4.44858061
13negative regulation of fibrinolysis (GO:0051918)4.39780725
14protein carboxylation (GO:0018214)4.36600284
15peptidyl-glutamic acid carboxylation (GO:0017187)4.36600284
16pre-miRNA processing (GO:0031054)4.35078738
17glyoxylate metabolic process (GO:0046487)4.30295552
18regulation of posttranscriptional gene silencing (GO:0060147)4.22389145
19regulation of gene silencing by miRNA (GO:0060964)4.22389145
20regulation of gene silencing by RNA (GO:0060966)4.22389145
21histone H3-K9 demethylation (GO:0033169)4.21498056
22regulation of fibrinolysis (GO:0051917)4.16702438
23histone H4-K8 acetylation (GO:0043982)4.09353757
24histone H4-K5 acetylation (GO:0043981)4.09353757
25nuclear pore organization (GO:0006999)4.01714543
26heterochromatin organization (GO:0070828)3.97298526
27nuclear pore complex assembly (GO:0051292)3.95248684
28male sex determination (GO:0030238)3.92451770
29folic acid-containing compound biosynthetic process (GO:0009396)3.83070851
30piRNA metabolic process (GO:0034587)3.82927758
31regulation of male gonad development (GO:2000018)3.79273051
32synaptonemal complex assembly (GO:0007130)3.78738951
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.78027857
34establishment of apical/basal cell polarity (GO:0035089)3.70907799
35nucleobase catabolic process (GO:0046113)3.70157844
36regulation of protein activation cascade (GO:2000257)3.68744410
37oocyte development (GO:0048599)3.65644901
38complement activation, alternative pathway (GO:0006957)3.59949781
39L-phenylalanine catabolic process (GO:0006559)3.58123510
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58123510
41negative regulation of meiosis (GO:0045835)3.51818820
42epoxygenase P450 pathway (GO:0019373)3.48202815
43intestinal cholesterol absorption (GO:0030299)3.47182228
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.45706661
45regulation of complement activation (GO:0030449)3.45634002
46histone H2A monoubiquitination (GO:0035518)3.45525406
47high-density lipoprotein particle remodeling (GO:0034375)3.44214582
48L-alpha-amino acid transmembrane transport (GO:1902475)3.43957562
49postsynaptic membrane organization (GO:0001941)3.39013992
50establishment or maintenance of monopolar cell polarity (GO:0061339)3.37893595
51establishment of monopolar cell polarity (GO:0061162)3.37893595
52oxidative demethylation (GO:0070989)3.36107174
53synaptonemal complex organization (GO:0070193)3.35867088
54amino-acid betaine metabolic process (GO:0006577)3.34452135
55meiosis I (GO:0007127)3.31704288
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.30621739
57serine family amino acid catabolic process (GO:0009071)3.28740852
58gene silencing by RNA (GO:0031047)3.28674776
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28390207
60cell migration in hindbrain (GO:0021535)3.27884010
61sex differentiation (GO:0007548)3.27078149
62neurotransmitter-gated ion channel clustering (GO:0072578)3.25417525
63ethanol oxidation (GO:0006069)3.24932765
64regulation of translational fidelity (GO:0006450)3.24273412
65DNA replication-dependent nucleosome assembly (GO:0006335)3.23027867
66DNA replication-dependent nucleosome organization (GO:0034723)3.23027867
67positive regulation of male gonad development (GO:2000020)3.22948197
68axon ensheathment in central nervous system (GO:0032291)3.21207515
69central nervous system myelination (GO:0022010)3.21207515
70cholesterol efflux (GO:0033344)3.16110961
71protein-lipid complex remodeling (GO:0034368)3.15608296
72macromolecular complex remodeling (GO:0034367)3.15608296
73plasma lipoprotein particle remodeling (GO:0034369)3.15608296
74DNA synthesis involved in DNA repair (GO:0000731)3.14897540
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.14831005
76peptidyl-lysine dimethylation (GO:0018027)3.13833064
77negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.13827389
78phospholipid efflux (GO:0033700)3.13307845
79reverse cholesterol transport (GO:0043691)3.11935664
80COPII vesicle coating (GO:0048208)3.11035749
81mitotic chromosome condensation (GO:0007076)3.10214663
82positive regulation of nuclease activity (GO:0032075)3.05421584
83regulation of triglyceride catabolic process (GO:0010896)3.04005940
84aromatic amino acid family catabolic process (GO:0009074)3.02369983
85poly(A)+ mRNA export from nucleus (GO:0016973)3.01523067
86regulation of hippo signaling (GO:0035330)2.99827192
87histone H3-K36 demethylation (GO:0070544)2.98419914
88blood coagulation, intrinsic pathway (GO:0007597)2.97774158
89establishment of mitochondrion localization (GO:0051654)2.96986553
90male meiosis (GO:0007140)2.96471832
91histone H4-K16 acetylation (GO:0043984)2.95867151
92chromatin assembly (GO:0031497)2.95680598
93gene silencing (GO:0016458)2.92110048
94plasma lipoprotein particle assembly (GO:0034377)2.91920788
95epithelial cell fate commitment (GO:0072148)2.91443314
96DNA methylation involved in gamete generation (GO:0043046)2.91370032
97negative regulation of histone methylation (GO:0031061)2.91262541
98drug metabolic process (GO:0017144)2.88648936
99S-adenosylmethionine metabolic process (GO:0046500)2.86851449
100neuron cell-cell adhesion (GO:0007158)2.85721241
101protein retention in ER lumen (GO:0006621)2.85137338
102very-low-density lipoprotein particle assembly (GO:0034379)2.84606761
103omega-hydroxylase P450 pathway (GO:0097267)2.83431606
104vesicle coating (GO:0006901)2.82199753
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82123467
106L-phenylalanine metabolic process (GO:0006558)2.82123467
107positive regulation of lipoprotein lipase activity (GO:0051006)2.79736395
108positive regulation of triglyceride lipase activity (GO:0061365)2.79736395
109regulation of nuclease activity (GO:0032069)2.79000047
110regulation of cholesterol esterification (GO:0010872)2.77610351
111peptidyl-glutamic acid modification (GO:0018200)2.77081225
112protein-lipid complex assembly (GO:0065005)2.76468252
113mitotic nuclear envelope disassembly (GO:0007077)2.76256308
114stress granule assembly (GO:0034063)2.75781399
115polarized epithelial cell differentiation (GO:0030859)2.75547589
116DNA strand renaturation (GO:0000733)2.75456618
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74671681
118fibrinolysis (GO:0042730)2.74650198
119nuclear envelope disassembly (GO:0051081)2.74368070
120membrane disassembly (GO:0030397)2.74368070
121triglyceride homeostasis (GO:0070328)2.74174573
122acylglycerol homeostasis (GO:0055090)2.74174573
123protein maturation by protein folding (GO:0022417)2.72343376
1242-oxoglutarate metabolic process (GO:0006103)2.71844419
125glandular epithelial cell development (GO:0002068)2.71837454
126histone lysine demethylation (GO:0070076)2.69300802
127lung epithelium development (GO:0060428)2.69298017
128dosage compensation (GO:0007549)2.69178755
129positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68017297
130phenylpropanoid metabolic process (GO:0009698)2.67014310
131embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66057612
132plasma lipoprotein particle organization (GO:0071827)2.65055712
133gonadal mesoderm development (GO:0007506)2.64215373
134paraxial mesoderm development (GO:0048339)2.62809804
135protein localization to synapse (GO:0035418)2.61224260
136regulation of DNA damage checkpoint (GO:2000001)2.61110926
137histone demethylation (GO:0016577)2.61089974
138negative regulation of lipid transport (GO:0032369)2.60930529
139neurotransmitter catabolic process (GO:0042135)2.60929834
140endocrine pancreas development (GO:0031018)2.60823857
141regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.59647745
142negative regulation of lipase activity (GO:0060192)2.59589669
143DNA methylation (GO:0006306)2.58883835
144DNA alkylation (GO:0006305)2.58883835
145pore complex assembly (GO:0046931)2.58718989
146protein-lipid complex subunit organization (GO:0071825)2.58255242
147arginine metabolic process (GO:0006525)2.58137829
148proline metabolic process (GO:0006560)2.56559856
149auditory behavior (GO:0031223)2.56436142
150regulation of chromatin binding (GO:0035561)2.55938832
151growth hormone secretion (GO:0030252)2.55299858
152histone arginine methylation (GO:0034969)2.55056805
153urea metabolic process (GO:0019627)2.54965134
154bile acid metabolic process (GO:0008206)2.54963766
155negative regulation of digestive system process (GO:0060457)2.53922999
156peptidyl-arginine omega-N-methylation (GO:0035247)2.53875746
157regulation of telomere maintenance via telomerase (GO:0032210)2.53639229
158bile acid biosynthetic process (GO:0006699)2.53488753
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.53230093
160tryptophan catabolic process (GO:0006569)2.52811293
161indole-containing compound catabolic process (GO:0042436)2.52811293
162indolalkylamine catabolic process (GO:0046218)2.52811293
163endoplasmic reticulum unfolded protein response (GO:0030968)2.52491333
164positive regulation of SMAD protein import into nucleus (GO:0060391)2.52213319
165regulation of NFAT protein import into nucleus (GO:0051532)2.52093703
166anterior/posterior axis specification, embryo (GO:0008595)2.51564679
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51515099
168positive regulation of synapse maturation (GO:0090129)2.50635490
169protein dealkylation (GO:0008214)2.49643747
170protein demethylation (GO:0006482)2.49643747
171neuronal ion channel clustering (GO:0045161)2.49626745
172mRNA transport (GO:0051028)2.49587963
173nucleobase biosynthetic process (GO:0046112)2.49365069
174mitotic sister chromatid segregation (GO:0000070)2.49199126
175histone H2A acetylation (GO:0043968)2.49031941
176proline biosynthetic process (GO:0006561)2.48744821
177protein localization to kinetochore (GO:0034501)2.48309347
178meiotic nuclear division (GO:0007126)2.48057731
179DNA duplex unwinding (GO:0032508)2.47244924
180regulation of histone H3-K9 methylation (GO:0051570)2.47223633
181DNA geometric change (GO:0032392)2.46242333
182cellular response to unfolded protein (GO:0034620)2.45183911
183chromosome organization involved in meiosis (GO:0070192)2.45161221
184IMP biosynthetic process (GO:0006188)2.44537381
185sister chromatid segregation (GO:0000819)2.42201298
186dorsal/ventral axis specification (GO:0009950)2.41640059
187mitotic G1 DNA damage checkpoint (GO:0031571)2.41168165
188regulation of helicase activity (GO:0051095)2.41117281
189pteridine-containing compound biosynthetic process (GO:0042559)2.39829637
190embryonic foregut morphogenesis (GO:0048617)2.39287368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.90207759
2EZH2_22144423_ChIP-Seq_EOC_Human4.17179154
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.15122675
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34442284
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34442284
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34442284
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.19564350
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.00381057
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.86564240
10DROSHA_22980978_ChIP-Seq_HELA_Human2.79382370
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.57488633
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.52390690
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49109083
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40293572
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.33543683
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20037443
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16674419
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15981894
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09395068
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.08977796
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05068573
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99552974
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98078817
24LXR_22292898_ChIP-Seq_THP-1_Human1.97855277
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.97767128
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97766886
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.97096765
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.96989803
29ZNF263_19887448_ChIP-Seq_K562_Human1.96032419
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95157296
31* P68_20966046_ChIP-Seq_HELA_Human1.94636733
32SMC4_20622854_ChIP-Seq_HELA_Human1.93716235
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93190885
34* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.92487707
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.92471132
36CTCF_27219007_Chip-Seq_Bcells_Human1.92440695
37REST_21632747_ChIP-Seq_MESCs_Mouse1.91878705
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89808747
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85191517
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83771388
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83486277
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83368705
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82080643
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.80894089
45KDM2B_26808549_Chip-Seq_K562_Human1.80577281
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80143670
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80013843
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78521929
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76603129
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75573902
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72390814
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72004345
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70457118
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69315249
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69099823
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68996364
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.68968839
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68055251
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67560029
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67551531
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.67219812
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64109825
63MYC_22102868_ChIP-Seq_BL_Human1.62236692
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61619210
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57330694
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56194196
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56092911
68* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55951619
69* ELF1_20517297_ChIP-Seq_JURKAT_Human1.55659464
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55425849
71* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54197334
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52174525
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51074598
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50918519
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49967333
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49213608
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47586882
78CIITA_25753668_ChIP-Seq_RAJI_Human1.46892672
79OCT4_19829295_ChIP-Seq_ESCs_Human1.46390740
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46316730
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46178326
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46129657
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45053383
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44025337
85* PHF8_20622854_ChIP-Seq_HELA_Human1.43614117
86E2F1_20622854_ChIP-Seq_HELA_Human1.42549689
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42497042
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42458951
89* BCL6_27268052_Chip-Seq_Bcells_Human1.42414409
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.42165085
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41430818
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41412693
93XRN2_22483619_ChIP-Seq_HELA_Human1.41381916
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.41362019
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41109300
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40483031
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.40276776
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38638507
99* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.38053483
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.38018465
101* KDM5A_27292631_Chip-Seq_BREAST_Human1.37631305
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.37629610
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.36078716
104JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35719889
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33832887
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.33251522
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33074857
108EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32496636
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32300470
110LXR_22158963_ChIP-Seq_LIVER_Mouse1.29989665
111ERA_21632823_ChIP-Seq_H3396_Human1.29458552
112TFEB_21752829_ChIP-Seq_HELA_Human1.29365993
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29339731
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29082308
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.27605268
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27328630
117EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27328630
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26856361
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26807823
120* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26607675
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.26205619
122GATA1_19941827_ChIP-Seq_MEL_Mouse1.25971128
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25362187
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24867097
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24324747
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23813543
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23804121
128* BCOR_27268052_Chip-Seq_Bcells_Human1.23198162
129CHD1_26751641_Chip-Seq_LNCaP_Human1.22907034
130GABP_19822575_ChIP-Seq_HepG2_Human1.22296345
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20160265
132VDR_21846776_ChIP-Seq_THP-1_Human1.20158676
133NANOG_16518401_ChIP-PET_MESCs_Mouse1.19304355
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19237338
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.18361876
136PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17514655
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15782004
138TET1_21451524_ChIP-Seq_MESCs_Mouse1.14917433
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14053268
140CREB1_26743006_Chip-Seq_LNCaP_Human1.13179971
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11769167
142RNF2_27304074_Chip-Seq_NSC_Mouse1.11237233
143TET1_21490601_ChIP-Seq_MESCs_Mouse1.08780129
144* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08776360
145SOX3_22085726_ChIP-Seq_NPCs_Mouse1.07626872
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07485816
147MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06514781
148AR_21909140_ChIP-Seq_LNCAP_Human1.06460191
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06045272
150CLOCK_20551151_ChIP-Seq_293T_Human1.05869621
151IGF1R_20145208_ChIP-Seq_DFB_Human1.05280404
152GATA1_19941826_ChIP-Seq_K562_Human1.05106775
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04930806
154CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04876447
155GATA1_22025678_ChIP-Seq_K562_Human1.04692788
156TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04285056
157ESR1_21235772_ChIP-Seq_MCF-7_Human1.04051959
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03253969
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03120277
160RARA_24833708_ChIP-Seq_LIVER_Mouse1.02841362
161POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02249402
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01529387
163SA1_27219007_Chip-Seq_Bcells_Human1.00531514
164CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00508829
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99935210
166RARB_24833708_ChIP-Seq_LIVER_Mouse0.99294993
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98842767
168KDM2B_26808549_Chip-Seq_JURKAT_Human0.98722297
169NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98390618
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.98088432
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97866479
172KAP1_27257070_Chip-Seq_ESCs_Mouse0.97490376
173WDR5_24793694_ChIP-Seq_LNCAP_Human0.97297112
174POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97108462
175OCT4_20526341_ChIP-Seq_ESCs_Human0.96978821
176ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96608780
177SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96358251
178SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96347532
179EED_16625203_ChIP-ChIP_MESCs_Mouse0.96080295
180ZNF274_21170338_ChIP-Seq_K562_Hela0.95815128
181* TP63_19390658_ChIP-ChIP_HaCaT_Human0.95794591
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95057913
183TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94996639
184TCF7_22412390_ChIP-Seq_EML_Mouse0.94818555
185TP63_22573176_ChIP-Seq_HFKS_Human0.94526699
186TTF2_22483619_ChIP-Seq_HELA_Human0.93874844
187RAC3_21632823_ChIP-Seq_H3396_Human0.93869427
188KDM2B_26808549_Chip-Seq_DND41_Human0.93578119
189* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93400844
190OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93395664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.23710996
2MP0003283_abnormal_digestive_organ4.24186061
3MP0008877_abnormal_DNA_methylation3.85046354
4MP0005365_abnormal_bile_salt3.06745994
5MP0003123_paternal_imprinting2.96125112
6MP0008995_early_reproductive_senescence2.83078889
7MP0005360_urolithiasis2.71150252
8MP0003122_maternal_imprinting2.63866567
9MP0003121_genomic_imprinting2.58288876
10MP0002822_catalepsy2.54128957
11MP0003119_abnormal_digestive_system2.45533990
12MP0003195_calcinosis2.44896121
13MP0002653_abnormal_ependyma_morphology2.44775483
14MP0002877_abnormal_melanocyte_morpholog2.44394456
15MP0008875_abnormal_xenobiotic_pharmacok2.33019104
16MP0004043_abnormal_pH_regulation2.31969771
17MP0009780_abnormal_chondrocyte_physiolo2.29569780
18MP0004859_abnormal_synaptic_plasticity2.28661417
19MP0005085_abnormal_gallbladder_physiolo2.19961795
20MP0003890_abnormal_embryonic-extraembry2.16084813
21MP0005076_abnormal_cell_differentiation2.13343537
22MP0000778_abnormal_nervous_system2.11131042
23MP0000678_abnormal_parathyroid_gland2.07651847
24MP0004957_abnormal_blastocyst_morpholog2.06921963
25MP0000566_synostosis2.01200677
26MP0010329_abnormal_lipoprotein_level1.97096033
27MP0003878_abnormal_ear_physiology1.91429849
28MP0005377_hearing/vestibular/ear_phenot1.91429849
29MP0003111_abnormal_nucleus_morphology1.89866609
30MP0004264_abnormal_extraembryonic_tissu1.88891470
31MP0002249_abnormal_larynx_morphology1.88040651
32MP0003329_amyloid_beta_deposits1.87709753
33MP0001502_abnormal_circadian_rhythm1.82333464
34MP0003787_abnormal_imprinting1.75867409
35MP0004133_heterotaxia1.72017811
36MP0001730_embryonic_growth_arrest1.72006217
37MP0008961_abnormal_basal_metabolism1.71817441
38MP0000013_abnormal_adipose_tissue1.71720390
39MP0006276_abnormal_autonomic_nervous1.71033530
40MP0002084_abnormal_developmental_patter1.70393617
41MP0002063_abnormal_learning/memory/cond1.70235298
42MP0002909_abnormal_adrenal_gland1.69691330
43MP0009840_abnormal_foam_cell1.69653741
44MP0005423_abnormal_somatic_nervous1.66497945
45MP0010094_abnormal_chromosome_stability1.63206065
46MP0003635_abnormal_synaptic_transmissio1.62139205
47MP0003786_premature_aging1.62074667
48MP0001944_abnormal_pancreas_morphology1.59540834
49MP0001986_abnormal_taste_sensitivity1.56446101
50MP0005058_abnormal_lysosome_morphology1.55573175
51MP0006072_abnormal_retinal_apoptosis1.51834198
52MP0003693_abnormal_embryo_hatching1.51312140
53MP0004197_abnormal_fetal_growth/weight/1.50298649
54MP0004233_abnormal_muscle_weight1.47455523
55MP0003077_abnormal_cell_cycle1.46769012
56MP0002085_abnormal_embryonic_tissue1.46374927
57MP0002064_seizures1.44810731
58MP0008057_abnormal_DNA_replication1.43385640
59MP0005409_darkened_coat_color1.41453899
60MP0000537_abnormal_urethra_morphology1.39245305
61MP0004742_abnormal_vestibular_system1.38341047
62MP0010352_gastrointestinal_tract_polyps1.38287025
63MP0001984_abnormal_olfaction1.37418264
64MP0002210_abnormal_sex_determination1.37048482
65MP0005380_embryogenesis_phenotype1.35723821
66MP0001672_abnormal_embryogenesis/_devel1.35723821
67MP0001486_abnormal_startle_reflex1.34654264
68MP0004130_abnormal_muscle_cell1.33733676
69MP0009672_abnormal_birth_weight1.32943143
70MP0001697_abnormal_embryo_size1.32125042
71MP0002557_abnormal_social/conspecific_i1.31970671
72MP0001145_abnormal_male_reproductive1.31710292
73MP0002638_abnormal_pupillary_reflex1.30602676
74MP0002572_abnormal_emotion/affect_behav1.29570039
75MP0004270_analgesia1.27656202
76MP0009745_abnormal_behavioral_response1.27452147
77MP0002693_abnormal_pancreas_physiology1.24347357
78MP0002086_abnormal_extraembryonic_tissu1.24260841
79MP0003984_embryonic_growth_retardation1.23430980
80MP0008058_abnormal_DNA_repair1.22876107
81MP0001666_abnormal_nutrient_absorption1.22622876
82MP0003880_abnormal_central_pattern1.21907455
83MP0002088_abnormal_embryonic_growth/wei1.21813038
84MP0000003_abnormal_adipose_tissue1.21245018
85MP0009703_decreased_birth_body1.20918779
86MP0005167_abnormal_blood-brain_barrier1.20017796
87MP0001929_abnormal_gametogenesis1.18829381
88MP0003252_abnormal_bile_duct1.18822861
89MP0000955_abnormal_spinal_cord1.18680814
90MP0003938_abnormal_ear_development1.18474036
91MP0003136_yellow_coat_color1.17650352
92MP0002234_abnormal_pharynx_morphology1.17285621
93MP0002118_abnormal_lipid_homeostasis1.16778650
94MP0003879_abnormal_hair_cell1.16552450
95MP0010030_abnormal_orbit_morphology1.16320910
96MP0000350_abnormal_cell_proliferation1.15659112
97MP0003942_abnormal_urinary_system1.14165920
98MP0002080_prenatal_lethality1.13716158
99MP0002138_abnormal_hepatobiliary_system1.12850203
100MP0004147_increased_porphyrin_level1.12642980
101MP0002882_abnormal_neuron_morphology1.10174461
102MP0005386_behavior/neurological_phenoty1.06734277
103MP0004924_abnormal_behavior1.06734277
104MP0005499_abnormal_olfactory_system1.06226426
105MP0005394_taste/olfaction_phenotype1.06226426
106MP0001849_ear_inflammation1.06002820
107MP0000653_abnormal_sex_gland1.05125831
108MP0001968_abnormal_touch/_nociception1.02793797
109MP0003690_abnormal_glial_cell1.02575305
110MP0003656_abnormal_erythrocyte_physiolo1.01605569
111MP0005248_abnormal_Harderian_gland1.01376768
112MP0000428_abnormal_craniofacial_morphol1.01173475
113MP0000631_abnormal_neuroendocrine_gland1.00893884
114MP0005220_abnormal_exocrine_pancreas1.00538132
115MP0001293_anophthalmia1.00233787
116MP0004142_abnormal_muscle_tone0.99957414
117MP0004858_abnormal_nervous_system0.99129655
118MP0002735_abnormal_chemical_nociception0.98525414
119MP0002733_abnormal_thermal_nociception0.98507600
120MP0003705_abnormal_hypodermis_morpholog0.97657470
121MP0004811_abnormal_neuron_physiology0.97024948
122MP0002876_abnormal_thyroid_physiology0.96972430
123MP0002152_abnormal_brain_morphology0.96383644
124MP0002184_abnormal_innervation0.95699652
125MP0001970_abnormal_pain_threshold0.95127229
126MP0008007_abnormal_cellular_replicative0.94507987
127MP0002089_abnormal_postnatal_growth/wei0.94325159
128MP0003698_abnormal_male_reproductive0.94114203
129MP0005535_abnormal_body_temperature0.93835951
130MP0009046_muscle_twitch0.93149424
131MP0010307_abnormal_tumor_latency0.93098668
132MP0000609_abnormal_liver_physiology0.92945251
133MP0002067_abnormal_sensory_capabilities0.92667879
134MP0002272_abnormal_nervous_system0.92310639
135MP0000026_abnormal_inner_ear0.91584883
136MP0003115_abnormal_respiratory_system0.91228703
137MP0002078_abnormal_glucose_homeostasis0.90356826
138MP0002971_abnormal_brown_adipose0.89600613
139MP0008932_abnormal_embryonic_tissue0.89342373
140MP0002697_abnormal_eye_size0.89271330
141MP0003861_abnormal_nervous_system0.88212786
142MP0002734_abnormal_mechanical_nocicepti0.88176086
143MP0000604_amyloidosis0.88175844
144MP0000534_abnormal_ureter_morphology0.87471231
145MP0006292_abnormal_olfactory_placode0.86986439
146MP0002161_abnormal_fertility/fecundity0.86271348
147MP0001529_abnormal_vocalization0.85550466
148MP0005448_abnormal_energy_balance0.84502822
149MP0004885_abnormal_endolymph0.83707793
150MP0002160_abnormal_reproductive_system0.83561610
151MP0005332_abnormal_amino_acid0.83172751
152MP0010234_abnormal_vibrissa_follicle0.82436156
153MP0002896_abnormal_bone_mineralization0.82059167
154MP0004145_abnormal_muscle_electrophysio0.81986984
155MP0001764_abnormal_homeostasis0.81680559
156MP0001727_abnormal_embryo_implantation0.81627353
157MP0000462_abnormal_digestive_system0.81475575
158MP0002066_abnormal_motor_capabilities/c0.81119408
159MP0001661_extended_life_span0.79449050
160MP0005187_abnormal_penis_morphology0.79061366
161MP0005646_abnormal_pituitary_gland0.78723315
162MP0003935_abnormal_craniofacial_develop0.78604572
163MP0001501_abnormal_sleep_pattern0.78156728
164MP0003936_abnormal_reproductive_system0.77241062
165MP0002751_abnormal_autonomic_nervous0.74926910
166MP0010386_abnormal_urinary_bladder0.73337673
167MP0003953_abnormal_hormone_level0.73086483
168MP0005389_reproductive_system_phenotype0.72962699
169MP0003172_abnormal_lysosome_physiology0.72012779
170MP0005623_abnormal_meninges_morphology0.71977456
171MP0002928_abnormal_bile_duct0.69861118
172MP0002269_muscular_atrophy0.67955016
173MP0009278_abnormal_bone_marrow0.67894891
174MP0002116_abnormal_craniofacial_bone0.67095378
175MP0002092_abnormal_eye_morphology0.66777832
176MP0002837_dystrophic_cardiac_calcinosis0.65769841

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.54226455
2Hyperinsulinemic hypoglycemia (HP:0000825)4.32688501
3Complement deficiency (HP:0004431)4.29192558
4Hand muscle atrophy (HP:0009130)4.14779370
5Ependymoma (HP:0002888)4.08852326
6Spontaneous abortion (HP:0005268)3.93976923
7Prolonged partial thromboplastin time (HP:0003645)3.68218618
8Hypobetalipoproteinemia (HP:0003563)3.60627122
9Abnormality of the lower motor neuron (HP:0002366)3.51518901
10Astrocytoma (HP:0009592)3.49960910
11Abnormality of the astrocytes (HP:0100707)3.49960910
12Joint hemorrhage (HP:0005261)3.44019383
13Hypoglycemic seizures (HP:0002173)3.43317414
14Reticulocytosis (HP:0001923)3.18070690
15Distal upper limb amyotrophy (HP:0007149)3.08444660
16Upper limb amyotrophy (HP:0009129)3.08444660
17Male infertility (HP:0003251)3.07448040
18Abnormality of complement system (HP:0005339)3.04791383
19Bronchomalacia (HP:0002780)3.02574259
20Sex reversal (HP:0012245)3.00020135
21Abnormal sex determination (HP:0012244)3.00020135
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.99826303
23Glioma (HP:0009733)2.95820252
24Systemic lupus erythematosus (HP:0002725)2.86026339
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.85892794
26Spinal muscular atrophy (HP:0007269)2.82871571
27Xanthomatosis (HP:0000991)2.82126500
28Hemorrhage of the eye (HP:0011885)2.77852281
29Symptomatic seizures (HP:0011145)2.74098401
30Abnormal pancreas size (HP:0012094)2.71426056
31Tongue fasciculations (HP:0001308)2.71093240
32Pancreatic islet-cell hyperplasia (HP:0004510)2.70731543
33Hyperlipoproteinemia (HP:0010980)2.69773077
34Shawl scrotum (HP:0000049)2.66946534
35Morphological abnormality of the inner ear (HP:0011390)2.64791590
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.64387257
37Abnormality of endocrine pancreas physiology (HP:0012093)2.63524044
38Abnormality of the pancreatic islet cells (HP:0006476)2.63524044
39Hypoglycemic coma (HP:0001325)2.62564444
40Muscle fibrillation (HP:0010546)2.53814969
41Glomerulonephritis (HP:0000099)2.49814669
42Hepatoblastoma (HP:0002884)2.49363617
43Conjugated hyperbilirubinemia (HP:0002908)2.46923487
44Vitreoretinal degeneration (HP:0000655)2.45043677
45Poikilocytosis (HP:0004447)2.44740675
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44292986
47Broad distal phalanx of finger (HP:0009836)2.43377855
48Degeneration of anterior horn cells (HP:0002398)2.41953535
49Abnormality of the anterior horn cell (HP:0006802)2.41953535
50Hyperglycemia (HP:0003074)2.41865677
51Unilateral renal agenesis (HP:0000122)2.40197917
52Renal duplication (HP:0000075)2.39297340
53Tubulointerstitial nephritis (HP:0001970)2.37699760
54Oligodactyly (hands) (HP:0001180)2.36654398
55Medulloblastoma (HP:0002885)2.35169007
56Neoplasm of the oral cavity (HP:0100649)2.34541283
57Hypercholesterolemia (HP:0003124)2.32881216
58Abnormality of the labia minora (HP:0012880)2.31700976
59Neoplasm of the heart (HP:0100544)2.27522382
60Arthropathy (HP:0003040)2.25686443
61Testicular neoplasm (HP:0010788)2.25381985
62Neoplasm of striated muscle (HP:0009728)2.22959736
63Gonadal dysgenesis (HP:0000133)2.18442698
64Papillary thyroid carcinoma (HP:0002895)2.16210556
65Broad palm (HP:0001169)2.09533362
66* Missing ribs (HP:0000921)2.09327186
67Delayed CNS myelination (HP:0002188)2.08730581
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06292687
69Absent epiphyses (HP:0010577)2.06292687
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.04976899
71Spastic gait (HP:0002064)2.04785867
72Abnormality of the musculature of the hand (HP:0001421)2.04528727
73Resting tremor (HP:0002322)2.04415978
74Rhabdomyosarcoma (HP:0002859)2.03241326
75Abnormality of reticulocytes (HP:0004312)2.02217141
76Ketoacidosis (HP:0001993)2.02190029
77Epileptic encephalopathy (HP:0200134)2.01875899
78Hyperglycinemia (HP:0002154)2.01001291
79Large for gestational age (HP:0001520)2.00394503
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.99915425
81Drooling (HP:0002307)1.99350636
82Urinary bladder sphincter dysfunction (HP:0002839)1.98568951
83Hypoplastic ischia (HP:0003175)1.97031698
84Abnormality of the aortic arch (HP:0012303)1.97018641
85Abnormal gallbladder physiology (HP:0012438)1.96111536
86Cholecystitis (HP:0001082)1.96111536
87Nephronophthisis (HP:0000090)1.95705384
88Obsessive-compulsive behavior (HP:0000722)1.94997776
89Neurofibrillary tangles (HP:0002185)1.94768138
90Prominent metopic ridge (HP:0005487)1.94414818
91Status epilepticus (HP:0002133)1.94144456
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93621148
93Hypoplasia of the brainstem (HP:0002365)1.93621148
94Macroorchidism (HP:0000053)1.91834657
95Heterotopia (HP:0002282)1.91585912
96Hyperacusis (HP:0010780)1.91108062
97Late onset (HP:0003584)1.91103845
98Short humerus (HP:0005792)1.90451035
99Hypoplastic labia majora (HP:0000059)1.90205524
100Rib fusion (HP:0000902)1.90007705
101Occipital encephalocele (HP:0002085)1.89573151
102Polyphagia (HP:0002591)1.87805058
103Turricephaly (HP:0000262)1.87454315
104Excessive salivation (HP:0003781)1.86791256
105Colon cancer (HP:0003003)1.84413201
106Aplasia/hypoplasia of the humerus (HP:0006507)1.84309350
107Bowel incontinence (HP:0002607)1.84273951
108Insulin-resistant diabetes mellitus (HP:0000831)1.84068789
109Amyotrophic lateral sclerosis (HP:0007354)1.83151668
110Ankle clonus (HP:0011448)1.82825081
111Abnormality of the renal medulla (HP:0100957)1.82800663
112Selective tooth agenesis (HP:0001592)1.82627501
113Clonus (HP:0002169)1.82100297
114Truncus arteriosus (HP:0001660)1.81712427
115Facial cleft (HP:0002006)1.81190360
116Male pseudohermaphroditism (HP:0000037)1.81134773
117Hyperventilation (HP:0002883)1.80799980
118Tracheomalacia (HP:0002779)1.80468051
119Aplasia/hypoplasia of the uterus (HP:0008684)1.80447966
120Wrist flexion contracture (HP:0001239)1.79893428
121Retinal dysplasia (HP:0007973)1.79315770
122Volvulus (HP:0002580)1.78941333
123Alacrima (HP:0000522)1.78682625
124Abnormality of the fingertips (HP:0001211)1.78610553
125Broad thumb (HP:0011304)1.78366106
126Cystic liver disease (HP:0006706)1.77744593
127Mesangial abnormality (HP:0001966)1.77732888
128Abnormality of the metopic suture (HP:0005556)1.77528055
129Genetic anticipation (HP:0003743)1.77445919
130Hyperthyroidism (HP:0000836)1.76691206
131Elfin facies (HP:0004428)1.76217507
132Retinal atrophy (HP:0001105)1.75519620
133Hypercalciuria (HP:0002150)1.75060710
134Abnormality of the common coagulation pathway (HP:0010990)1.74778501
135Insomnia (HP:0100785)1.74497610
136Gonadotropin excess (HP:0000837)1.74257298
137Nephritis (HP:0000123)1.74021764
138Peripheral hypomyelination (HP:0007182)1.72969145
139Gout (HP:0001997)1.72846367
140Facial hemangioma (HP:0000329)1.72783852
141Abnormal biliary tract physiology (HP:0012439)1.72743660
142Bile duct proliferation (HP:0001408)1.72743660
143Shoulder girdle muscle weakness (HP:0003547)1.72551800
144Intestinal polyp (HP:0005266)1.71868693
145Hypolipoproteinemia (HP:0010981)1.71274153
146Progressive cerebellar ataxia (HP:0002073)1.71256020
147Ovarian neoplasm (HP:0100615)1.70838250
148Visual hallucinations (HP:0002367)1.70663351
149Pseudobulbar signs (HP:0002200)1.70558256
150Intestinal polyposis (HP:0200008)1.69973155
151Increased nuchal translucency (HP:0010880)1.69726317
152Intellectual disability, severe (HP:0010864)1.69565733
153Abnormality of the ischium (HP:0003174)1.69516374
154Supranuclear gaze palsy (HP:0000605)1.69397002
155Hypoplasia of the corpus callosum (HP:0002079)1.68931828
156Renovascular hypertension (HP:0100817)1.67442472
157Abnormality of calcium-phosphate metabolism (HP:0100530)1.66773280
158Severe Myopia (HP:0011003)1.66328688
159Orthostatic hypotension (HP:0001278)1.66310060
160Cholelithiasis (HP:0001081)1.65755964
161Onion bulb formation (HP:0003383)1.65693181
162Angiofibromas (HP:0010615)1.65286557
163Adenoma sebaceum (HP:0009720)1.65286557
164Abnormality of the labia majora (HP:0012881)1.64925188
165Ketosis (HP:0001946)1.64896191
166Abnormality of the corticospinal tract (HP:0002492)1.64573257
167Hypsarrhythmia (HP:0002521)1.64296506
168Epidermoid cyst (HP:0200040)1.63613899
169Osteomalacia (HP:0002749)1.62859827
170Bicornuate uterus (HP:0000813)1.61946804
171Truncal obesity (HP:0001956)1.61904862
172Abnormality of cochlea (HP:0000375)1.61593824
173Bifid tongue (HP:0010297)1.60794959
174Flattened epiphyses (HP:0003071)1.60395834
175Deep palmar crease (HP:0006191)1.59873035
176Cerebral palsy (HP:0100021)1.59721425
177Abnormality of the salivary glands (HP:0010286)1.59201818
178Abnormal large intestine physiology (HP:0012700)1.59050364
179Hyperglycinuria (HP:0003108)1.58985674
180EEG with generalized epileptiform discharges (HP:0011198)1.58405909
181Malignant neoplasm of the central nervous system (HP:0100836)1.58357255
182Hypopigmentation of the fundus (HP:0007894)1.57277809
183Labial hypoplasia (HP:0000066)1.56590940
184Impulsivity (HP:0100710)1.56117405
185Pelvic girdle muscle weakness (HP:0003749)1.55400783
186High anterior hairline (HP:0009890)1.53438258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.79086155
2PASK3.40947498
3WNK33.25985283
4SIK23.21486062
5PRKD32.79970515
6INSRR2.47238181
7CDC72.34292535
8NTRK22.22674315
9TYRO32.21641504
10ICK2.21134413
11BRD42.15156279
12FGFR42.14512594
13CASK1.91102652
14NEK11.90078260
15SCYL21.87799981
16TRIB31.87314093
17PDGFRA1.86685426
18MARK21.84628322
19EPHA21.71864775
20BMX1.66016282
21AKT31.59212425
22MAP3K61.58700848
23TTK1.57272690
24MAPK151.56910337
25WNK41.55549471
26FGFR21.53644528
27EPHA41.52217877
28MTOR1.51274110
29CDK191.50099119
30MAP3K91.48050952
31MAP3K41.47899061
32FGFR31.47277892
33NEK21.45232421
34MAP2K41.43238369
35MAP3K71.40161735
36PKN21.39242656
37SIK11.34192733
38EEF2K1.33642262
39CDC42BPA1.31681087
40LATS21.30876805
41TNK21.27470743
42MAP3K101.26485879
43MAPK131.25780889
44CDK71.25622569
45LATS11.23923393
46FLT31.21631260
47EPHA31.21248639
48NTRK31.19936133
49MAP3K21.16897366
50ALK1.15528839
51PTK61.15492330
52PLK11.13090940
53RIPK11.11981115
54WEE11.11653029
55PTK21.10245651
56PAK41.10001477
57STK38L1.09072777
58MAP2K71.07908667
59TSSK61.07226642
60SGK2231.06673377
61SGK4941.06673377
62ATR1.06339492
63UHMK11.03660683
64ERN11.03142614
65CHEK11.01368517
66CAMKK11.00516362
67PTK2B0.97744443
68CSF1R0.97609871
69FGR0.96396596
70PNCK0.95347715
71WNK10.90586028
72BUB10.90344134
73HIPK20.88977479
74DYRK1A0.87625631
75DYRK20.87495531
76DAPK10.87419393
77PDK30.84736548
78PDK40.84736548
79CHEK20.84376102
80CAMK1D0.84157199
81* CDK20.84088665
82PRKCI0.83379467
83MARK10.82569202
84RPS6KB20.81935470
85STK380.81630549
86PRPF4B0.81199747
87CDK50.80966568
88MAPK110.79620361
89MAP2K20.79022179
90MAPK120.78899622
91PKN10.78307233
92PAK30.78109157
93ATM0.77973548
94NTRK10.75096916
95MAP2K60.74611984
96DYRK1B0.74136504
97PRKCZ0.74127253
98SGK20.73502324
99PINK10.72517515
100DDR20.71515126
101STK110.70030749
102CAMK1G0.69584045
103BRSK20.69446656
104PDPK10.69266325
105FER0.68762348
106RPS6KA20.67653502
107ACVR1B0.66946324
108SGK10.66359302
109PLK30.64969959
110PAK60.64534476
111KSR10.64177741
112CSNK1E0.63873363
113CDK90.63292286
114CDK10.62608726
115PRKDC0.61321124
116MET0.60782644
117MAP3K110.60303661
118JAK20.59898575
119PDK10.59775700
120BRSK10.59670036
121PRKD20.58143118
122SRPK10.57746343
123PRKAA20.57737718
124MAPKAPK30.56871369
125SGK30.56284084
126AURKA0.56085763
127CDK40.55461917
128AURKB0.55262286
129PAK20.54995694
130PDGFRB0.54873721
131MAPK140.54770475
132PRKCG0.54195210
133PRKAA10.52710971
134IRAK10.52403276
135KSR20.51939026
136CDK11A0.51897865
137TYK20.50391978
138* GSK3B0.49893810
139OXSR10.49286415
140PHKG10.49014870
141PHKG20.49014870
142MAPK100.47429249
143TESK10.46512886
144DYRK30.46178277
145CAMK10.45655077
146FGFR10.45470005
147* MAPK80.45286746
148MINK10.45176841
149ERBB20.44498825
150FES0.44395556
151CAMK40.43852511
152* MAPK30.43547169
153RET0.43187958
154CSNK1A1L0.42113177
155AKT10.41553334
156DAPK20.41178761
157RPS6KB10.40560355
158RPS6KA30.40479188
159RPS6KA60.40469849
160CDK150.39138965
161CCNB10.38058845

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.38272844
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98797351
3Complement and coagulation cascades_Homo sapiens_hsa046102.77384281
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.67496689
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47555034
6Caffeine metabolism_Homo sapiens_hsa002322.43039629
7RNA transport_Homo sapiens_hsa030132.29797734
8Selenocompound metabolism_Homo sapiens_hsa004502.27069579
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21757592
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.18828859
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15408951
12mRNA surveillance pathway_Homo sapiens_hsa030152.14956504
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14219596
14Retinol metabolism_Homo sapiens_hsa008302.13937879
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08101493
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04190030
17Mismatch repair_Homo sapiens_hsa034301.98413195
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97533835
19Insulin secretion_Homo sapiens_hsa049111.95499328
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92582516
21Bile secretion_Homo sapiens_hsa049761.91603925
22Lysine degradation_Homo sapiens_hsa003101.86396711
23Linoleic acid metabolism_Homo sapiens_hsa005911.84555703
24One carbon pool by folate_Homo sapiens_hsa006701.83814378
25Arginine biosynthesis_Homo sapiens_hsa002201.73301323
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70784553
27Fatty acid degradation_Homo sapiens_hsa000711.70005181
28ABC transporters_Homo sapiens_hsa020101.68733780
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.61854528
30Spliceosome_Homo sapiens_hsa030401.60011555
31Type II diabetes mellitus_Homo sapiens_hsa049301.56524854
32Chemical carcinogenesis_Homo sapiens_hsa052041.55998839
33Hedgehog signaling pathway_Homo sapiens_hsa043401.54843499
34Phenylalanine metabolism_Homo sapiens_hsa003601.54530895
35mTOR signaling pathway_Homo sapiens_hsa041501.51048854
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45736768
37Cell cycle_Homo sapiens_hsa041101.45601093
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42081884
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39155890
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38650513
41Oocyte meiosis_Homo sapiens_hsa041141.38373849
42Other glycan degradation_Homo sapiens_hsa005111.35890037
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35634595
44Histidine metabolism_Homo sapiens_hsa003401.33872572
45PPAR signaling pathway_Homo sapiens_hsa033201.33542435
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33127606
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28065426
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25616990
49Hippo signaling pathway_Homo sapiens_hsa043901.25094410
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24307167
51Basal cell carcinoma_Homo sapiens_hsa052171.23629812
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23003356
53DNA replication_Homo sapiens_hsa030301.21911963
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.20533590
55Glucagon signaling pathway_Homo sapiens_hsa049221.19859511
56Tyrosine metabolism_Homo sapiens_hsa003501.19170120
57Nicotine addiction_Homo sapiens_hsa050331.16551041
58Fat digestion and absorption_Homo sapiens_hsa049751.15999593
59Biosynthesis of amino acids_Homo sapiens_hsa012301.10366764
60Homologous recombination_Homo sapiens_hsa034401.09801773
61Steroid biosynthesis_Homo sapiens_hsa001001.09603379
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08249508
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07036987
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07001193
65Base excision repair_Homo sapiens_hsa034101.06936728
66Sulfur relay system_Homo sapiens_hsa041221.05947419
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05316120
68Protein export_Homo sapiens_hsa030601.04946071
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03248372
70Peroxisome_Homo sapiens_hsa041461.03199589
71Fanconi anemia pathway_Homo sapiens_hsa034601.03087636
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01856868
73Central carbon metabolism in cancer_Homo sapiens_hsa052301.01575240
74Dorso-ventral axis formation_Homo sapiens_hsa043201.01153554
75Cocaine addiction_Homo sapiens_hsa050301.00447656
76Nucleotide excision repair_Homo sapiens_hsa034200.99985738
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98980085
78N-Glycan biosynthesis_Homo sapiens_hsa005100.98869802
79Thyroid cancer_Homo sapiens_hsa052160.96754564
80Synaptic vesicle cycle_Homo sapiens_hsa047210.96050623
81Notch signaling pathway_Homo sapiens_hsa043300.93159805
82Insulin resistance_Homo sapiens_hsa049310.92595660
83Type I diabetes mellitus_Homo sapiens_hsa049400.91434724
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91012295
85RNA polymerase_Homo sapiens_hsa030200.90618978
86Estrogen signaling pathway_Homo sapiens_hsa049150.90504576
87Choline metabolism in cancer_Homo sapiens_hsa052310.89755790
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.86452424
89GABAergic synapse_Homo sapiens_hsa047270.84549023
90Endometrial cancer_Homo sapiens_hsa052130.83979581
91Glutamatergic synapse_Homo sapiens_hsa047240.83860296
92RNA degradation_Homo sapiens_hsa030180.83050078
93Fructose and mannose metabolism_Homo sapiens_hsa000510.82701752
94Amphetamine addiction_Homo sapiens_hsa050310.82003606
95VEGF signaling pathway_Homo sapiens_hsa043700.81477811
96Insulin signaling pathway_Homo sapiens_hsa049100.81058871
97Vibrio cholerae infection_Homo sapiens_hsa051100.80201055
98AMPK signaling pathway_Homo sapiens_hsa041520.79730233
99Arginine and proline metabolism_Homo sapiens_hsa003300.79122590
100Tight junction_Homo sapiens_hsa045300.79085306
101Axon guidance_Homo sapiens_hsa043600.78469523
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77699674
103Wnt signaling pathway_Homo sapiens_hsa043100.77407267
104Adherens junction_Homo sapiens_hsa045200.77194842
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.76494520
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76491534
107Basal transcription factors_Homo sapiens_hsa030220.76411182
108Long-term potentiation_Homo sapiens_hsa047200.72050733
109Circadian entrainment_Homo sapiens_hsa047130.71853100
110Starch and sucrose metabolism_Homo sapiens_hsa005000.71218993
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70428806
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69977855
113Bladder cancer_Homo sapiens_hsa052190.69408154
114Dopaminergic synapse_Homo sapiens_hsa047280.66509214
115Thyroid hormone synthesis_Homo sapiens_hsa049180.65847070
116Galactose metabolism_Homo sapiens_hsa000520.64791040
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64209753
118Glycerolipid metabolism_Homo sapiens_hsa005610.63422064
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.63094822
120Colorectal cancer_Homo sapiens_hsa052100.63088253
121Ether lipid metabolism_Homo sapiens_hsa005650.62200741
122* Alcoholism_Homo sapiens_hsa050340.61916461
123MicroRNAs in cancer_Homo sapiens_hsa052060.61786291
124beta-Alanine metabolism_Homo sapiens_hsa004100.61679271
125Staphylococcus aureus infection_Homo sapiens_hsa051500.60877256
126Morphine addiction_Homo sapiens_hsa050320.60179057
127ErbB signaling pathway_Homo sapiens_hsa040120.60120611
128Carbon metabolism_Homo sapiens_hsa012000.59427884
129Prion diseases_Homo sapiens_hsa050200.56303439
130Arachidonic acid metabolism_Homo sapiens_hsa005900.54648067
131p53 signaling pathway_Homo sapiens_hsa041150.54349269
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53395328
133Pyruvate metabolism_Homo sapiens_hsa006200.52260259
134Butanoate metabolism_Homo sapiens_hsa006500.52068695
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.51242121
136Circadian rhythm_Homo sapiens_hsa047100.50968525
137Gap junction_Homo sapiens_hsa045400.50786755
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50451282
139TGF-beta signaling pathway_Homo sapiens_hsa043500.49275788
140Cholinergic synapse_Homo sapiens_hsa047250.48918064
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.48808020
142Sulfur metabolism_Homo sapiens_hsa009200.48623673
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.48255265
144Melanogenesis_Homo sapiens_hsa049160.47828086
145Pyrimidine metabolism_Homo sapiens_hsa002400.47484850
146Fatty acid metabolism_Homo sapiens_hsa012120.47396706
147Ovarian steroidogenesis_Homo sapiens_hsa049130.46721956
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44626817
149Fatty acid biosynthesis_Homo sapiens_hsa000610.44452616
150GnRH signaling pathway_Homo sapiens_hsa049120.43126842
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42635882
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42412256
153Tryptophan metabolism_Homo sapiens_hsa003800.42353732
154Propanoate metabolism_Homo sapiens_hsa006400.41906475
155* Viral carcinogenesis_Homo sapiens_hsa052030.41105684
156Inositol phosphate metabolism_Homo sapiens_hsa005620.40421154
157Glioma_Homo sapiens_hsa052140.40407059
158Prolactin signaling pathway_Homo sapiens_hsa049170.40257908
159HTLV-I infection_Homo sapiens_hsa051660.39989710
160Lysosome_Homo sapiens_hsa041420.39435367
161Prostate cancer_Homo sapiens_hsa052150.39095140
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37884215
163Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37111226
164Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36818492
165Long-term depression_Homo sapiens_hsa047300.35723823
166Regulation of autophagy_Homo sapiens_hsa041400.34189638

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