HDAC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41184546
2regulation of gamma-delta T cell differentiation (GO:0045586)6.34423785
3regulation of gamma-delta T cell activation (GO:0046643)5.59737414
4positive thymic T cell selection (GO:0045059)5.12652895
5negative T cell selection (GO:0043383)5.03102404
6positive T cell selection (GO:0043368)5.00086603
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73918304
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.73918304
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59381286
10T cell selection (GO:0045058)4.51943990
11negative thymic T cell selection (GO:0045060)4.50082448
12positive regulation of histone deacetylation (GO:0031065)4.43425967
13thymic T cell selection (GO:0045061)4.34302831
14V(D)J recombination (GO:0033151)4.29110657
15negative regulation of thymocyte apoptotic process (GO:0070244)4.24711913
16response to interleukin-15 (GO:0070672)4.13565988
17antigen processing and presentation of endogenous antigen (GO:0019883)4.00600330
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.99859361
19interferon-gamma production (GO:0032609)3.98805682
20Peyers patch development (GO:0048541)3.77262605
21mucosal-associated lymphoid tissue development (GO:0048537)3.77262605
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.70956823
23mannose metabolic process (GO:0006013)3.69806876
24negative regulation of erythrocyte differentiation (GO:0045647)3.69740887
25endothelial tube morphogenesis (GO:0061154)3.69276894
26morphogenesis of an endothelium (GO:0003159)3.69276894
27T cell receptor signaling pathway (GO:0050852)3.67372391
28positive regulation of protein deacetylation (GO:0090312)3.64261611
29regulation of interleukin-2 biosynthetic process (GO:0045076)3.59237497
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.57538394
31negative regulation of cell killing (GO:0031342)3.57498523
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57498523
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55213224
34natural killer cell differentiation (GO:0001779)3.53337841
35T cell homeostasis (GO:0043029)3.46031876
36T cell costimulation (GO:0031295)3.39016553
37positive regulation of interleukin-2 production (GO:0032743)3.36993406
38regulation of regulatory T cell differentiation (GO:0045589)3.35956404
39lymphocyte costimulation (GO:0031294)3.31719755
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.29063761
41modulation by symbiont of host immune response (GO:0052553)3.29063761
42positive regulation by symbiont of host defense response (GO:0052509)3.29063761
43modulation by symbiont of host defense response (GO:0052031)3.29063761
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29063761
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29063761
46cellular hyperosmotic response (GO:0071474)3.27080887
47antigen receptor-mediated signaling pathway (GO:0050851)3.24381699
48germinal center formation (GO:0002467)3.20653432
49negative regulation of phagocytosis (GO:0050765)3.12534140
50response to laminar fluid shear stress (GO:0034616)3.11386972
51response to muramyl dipeptide (GO:0032495)3.10947781
52viral transcription (GO:0019083)3.10689032
53DNA unwinding involved in DNA replication (GO:0006268)3.06619709
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04791880
55positive regulation of gene expression, epigenetic (GO:0045815)3.03851111
56cellular response to interleukin-15 (GO:0071350)3.02710397
57tolerance induction (GO:0002507)3.00160662
58regulation of T cell tolerance induction (GO:0002664)3.00099725
59activated T cell proliferation (GO:0050798)2.97823944
60regulation of thymocyte apoptotic process (GO:0070243)2.97104608
61T cell differentiation (GO:0030217)2.94543420
62positive regulation of granulocyte differentiation (GO:0030854)2.93425618
63positive regulation of tolerance induction (GO:0002645)2.93084058
64detection of bacterium (GO:0016045)2.90269347
65regulation of isotype switching to IgG isotypes (GO:0048302)2.89976686
66positive regulation of B cell differentiation (GO:0045579)2.89974395
67detection of other organism (GO:0098543)2.89937102
68translational termination (GO:0006415)2.89734603
69stress fiber assembly (GO:0043149)2.88918324
70positive regulation of isotype switching (GO:0045830)2.88516521
71B cell receptor signaling pathway (GO:0050853)2.88126168
72ribosomal small subunit assembly (GO:0000028)2.87848837
73regulation of histone H3-K27 methylation (GO:0061085)2.83292110
74leukocyte aggregation (GO:0070486)2.81357450
75apoptotic process involved in morphogenesis (GO:0060561)2.80880631
76cellular extravasation (GO:0045123)2.78666102
77cellular response to interleukin-4 (GO:0071353)2.77666933
78tyrosine phosphorylation of STAT protein (GO:0007260)2.76260265
79regulation of extracellular matrix disassembly (GO:0010715)2.74104422
80establishment of endothelial barrier (GO:0061028)2.72712592
81megakaryocyte development (GO:0035855)2.72384991
82lymphocyte homeostasis (GO:0002260)2.72144637
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71237370
84atrioventricular valve morphogenesis (GO:0003181)2.71047248
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70748685
86regulation of T-helper 2 cell differentiation (GO:0045628)2.69698011
87negative regulation of RNA splicing (GO:0033119)2.69633452
88regulation of B cell differentiation (GO:0045577)2.69581862
89cell-substrate adherens junction assembly (GO:0007045)2.69479958
90focal adhesion assembly (GO:0048041)2.69479958
91regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68214657
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.67838718
93protein localization to kinetochore (GO:0034501)2.67155006
94lymph node development (GO:0048535)2.67068698
95regulation of ARF GTPase activity (GO:0032312)2.65198808
96alternative mRNA splicing, via spliceosome (GO:0000380)2.64975624
97antigen processing and presentation via MHC class Ib (GO:0002475)2.64826264
98adherens junction assembly (GO:0034333)2.63498809
99positive regulation of natural killer cell differentiation (GO:0032825)2.63068359
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62117615
1013-UTR-mediated mRNA stabilization (GO:0070935)2.61860616
102regulation of necroptotic process (GO:0060544)2.61052797
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60973099
104regulation of T cell receptor signaling pathway (GO:0050856)2.60852890
105cell-substrate junction assembly (GO:0007044)2.59652143
106translational elongation (GO:0006414)2.57777392
107regulation of B cell receptor signaling pathway (GO:0050855)2.56618571
108T cell migration (GO:0072678)2.56497637
109ribosomal small subunit biogenesis (GO:0042274)2.55901159
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55831762
111response to peptidoglycan (GO:0032494)2.55596162
112embryonic hemopoiesis (GO:0035162)2.55352317
113definitive hemopoiesis (GO:0060216)2.54864032
114barbed-end actin filament capping (GO:0051016)2.54823215
115regulation of histone H3-K4 methylation (GO:0051569)2.53822084
116positive regulation of receptor recycling (GO:0001921)2.53538445
117modulation by symbiont of host cellular process (GO:0044068)2.53416683
118macrophage activation involved in immune response (GO:0002281)2.53296672
119nucleosome disassembly (GO:0006337)2.52845626
120protein-DNA complex disassembly (GO:0032986)2.52845626
121mRNA stabilization (GO:0048255)2.52720405
122RNA stabilization (GO:0043489)2.52720405
123signal complex assembly (GO:0007172)2.52142491
124natural killer cell activation (GO:0030101)2.51446366
125embryonic process involved in female pregnancy (GO:0060136)2.51314138
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51048978
127positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51046651
128response to interleukin-4 (GO:0070670)2.49567343
129* positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47282004
130negative regulation of type 2 immune response (GO:0002829)2.47262338
131* regulation of interleukin-2 production (GO:0032663)2.47238444
132positive regulation of natural killer cell mediated immunity (GO:0002717)2.46500135
133positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.46500135
134NIK/NF-kappaB signaling (GO:0038061)2.46015565
135detection of external biotic stimulus (GO:0098581)2.45787911
136negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45609056
137negative regulation of granulocyte differentiation (GO:0030853)2.45179067
138positive regulation by host of viral transcription (GO:0043923)2.44934747
139alpha-beta T cell activation (GO:0046631)2.44582901
140T cell activation (GO:0042110)2.43997365
141T cell differentiation in thymus (GO:0033077)2.43895992
142activation of JUN kinase activity (GO:0007257)2.43404464
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.43260436
144protein localization to endosome (GO:0036010)2.43239494
145modulation by virus of host process (GO:0019054)2.42854235
146regulation of natural killer cell mediated immunity (GO:0002715)2.42774433
147regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.42774433
148pinocytosis (GO:0006907)2.42448060
149vascular endothelial growth factor signaling pathway (GO:0038084)2.38651614
150vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36556786
151negative regulation of cell size (GO:0045792)2.34705595
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.34049902
153negative regulation of leukocyte mediated immunity (GO:0002704)2.32814174
154positive regulation of Rap GTPase activity (GO:0032854)2.32447882
155regulation of interferon-beta biosynthetic process (GO:0045357)2.32189429
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.31462116
157response to fluid shear stress (GO:0034405)2.31012845
158semaphorin-plexin signaling pathway (GO:0071526)2.29382728
159venous blood vessel morphogenesis (GO:0048845)2.28968493
160negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28840500
161negative regulation of T-helper cell differentiation (GO:0045623)2.28840500
162negative regulation of necroptotic process (GO:0060546)2.28616810
163response to host (GO:0075136)2.28549680
164response to host defenses (GO:0052200)2.28549680
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28549680
166cellular response to virus (GO:0098586)2.28343958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42575761
2* MYC_22102868_ChIP-Seq_BL_Human4.55425487
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97678189
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88884041
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.73376806
6VDR_21846776_ChIP-Seq_THP-1_Human3.25295260
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12075329
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.86530772
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.71307910
10MAF_26560356_Chip-Seq_TH1_Human2.61341417
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58620521
12* UTX_26944678_Chip-Seq_JUKART_Human2.54021511
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.43011444
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41185335
15SCL_19346495_ChIP-Seq_HPC-7_Human2.40941769
16* KDM2B_26808549_Chip-Seq_DND41_Human2.40500112
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35820109
18RUNX_20019798_ChIP-Seq_JUKART_Human2.35120154
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.34738819
20* MYB_26560356_Chip-Seq_TH2_Human2.34481293
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.32415269
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30013379
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25399219
24* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17521491
25MYB_26560356_Chip-Seq_TH1_Human2.13648129
26VDR_24763502_ChIP-Seq_THP-1_Human1.99343391
27CIITA_25753668_ChIP-Seq_RAJI_Human1.98742038
28* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86486915
29MAF_26560356_Chip-Seq_TH2_Human1.81643130
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77777276
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76021505
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74998331
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74302867
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73184740
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68273858
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67283978
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67278134
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65218387
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64845013
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.59983502
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55872203
42* KDM2B_26808549_Chip-Seq_JURKAT_Human1.54773728
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.54529274
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53820792
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51046436
46LXR_22292898_ChIP-Seq_THP-1_Human1.47498863
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.46899756
48* SPI1_23127762_ChIP-Seq_K562_Human1.42627214
49NCOR1_26117541_ChIP-Seq_K562_Human1.41124504
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.40889807
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40625986
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.40393356
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37961286
54* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37920466
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35659024
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35407812
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34922676
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.33295249
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32076055
60GATA1_19941826_ChIP-Seq_K562_Human1.30237305
61SPI1_23547873_ChIP-Seq_NB4_Human1.29865508
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29154217
63* GATA3_27048872_Chip-Seq_THYMUS_Human1.26193402
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25349341
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.23222274
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21271246
67CREB1_26743006_Chip-Seq_LNCaP_Human1.18077070
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.17699320
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17210103
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15515273
71* SMC4_20622854_ChIP-Seq_HELA_Human1.15432628
72* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14833897
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13882608
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.13584695
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13481984
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12697769
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10246471
78* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10153379
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08956110
80XRN2_22483619_ChIP-Seq_HELA_Human1.08676695
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07703668
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.07648436
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07513488
84* GATA2_21666600_ChIP-Seq_HMVEC_Human1.07167002
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06828994
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06280604
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05906941
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05391013
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04373118
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.04372603
91* RUNX1_27514584_Chip-Seq_MCF-7_Human1.04212412
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03861883
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.03842937
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03651406
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02837818
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01080504
97* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01080177
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00901627
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99779999
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99246062
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98980161
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98886942
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98424630
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98283788
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97555133
106* BCOR_27268052_Chip-Seq_Bcells_Human0.97200510
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96900369
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96563560
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95884508
110CLOCK_20551151_ChIP-Seq_293T_Human0.95721706
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94887030
112TP53_22127205_ChIP-Seq_IMR90_Human0.94620220
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94554763
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94539114
115* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93208440
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.93076222
117* ATF3_27146783_Chip-Seq_COLON_Human0.91317585
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91081459
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90311336
120* P68_20966046_ChIP-Seq_HELA_Human0.89758392
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89748282
122* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88896574
123* CTCF_21964334_Chip-Seq_Bcells_Human0.87653816
124RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87621785
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87021049
126KDM2B_26808549_Chip-Seq_K562_Human0.86848633
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86090848
128KDM5A_27292631_Chip-Seq_BREAST_Human0.86062144
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85257385
130FOXP3_21729870_ChIP-Seq_TREG_Human0.84870365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.76499905
2MP0002396_abnormal_hematopoietic_system3.53062583
3MP0000685_abnormal_immune_system2.91755026
4MP0004808_abnormal_hematopoietic_stem2.66222102
5MP0003300_gastrointestinal_ulcer2.63723929
6MP0000703_abnormal_thymus_morphology2.57520311
7MP0002166_altered_tumor_susceptibility2.53483575
8MP0005671_abnormal_response_to2.40155462
9MP0010352_gastrointestinal_tract_polyps2.33665929
10MP0002398_abnormal_bone_marrow2.31335283
11MP0009278_abnormal_bone_marrow2.29309716
12MP0010368_abnormal_lymphatic_system2.23875696
13MP0001800_abnormal_humoral_immune2.22580578
14MP0005387_immune_system_phenotype2.15200386
15MP0001790_abnormal_immune_system2.15200386
16MP0001879_abnormal_lymphatic_vessel2.02989574
17MP0003303_peritoneal_inflammation2.01250525
18MP0003705_abnormal_hypodermis_morpholog1.99949166
19MP0002722_abnormal_immune_system1.98654871
20MP0009333_abnormal_splenocyte_physiolog1.97127032
21MP0006054_spinal_hemorrhage1.89744608
22MP0001545_abnormal_hematopoietic_system1.85658304
23MP0005397_hematopoietic_system_phenotyp1.85658304
24MP0008260_abnormal_autophagy1.83632986
25MP0000689_abnormal_spleen_morphology1.83267894
26MP0002405_respiratory_system_inflammati1.82088132
27MP0003279_aneurysm1.81745529
28MP0000716_abnormal_immune_system1.81545964
29MP0010155_abnormal_intestine_physiology1.81270160
30MP0002006_tumorigenesis1.79164131
31MP0002420_abnormal_adaptive_immunity1.79081308
32MP0001819_abnormal_immune_cell1.74645691
33MP0005451_abnormal_body_composition1.72249744
34MP0005275_abnormal_skin_tensile1.71242382
35MP0002132_abnormal_respiratory_system1.67743601
36MP0001835_abnormal_antigen_presentation1.67342058
37MP0002723_abnormal_immune_serum1.67003827
38MP0002933_joint_inflammation1.66381293
39MP0002419_abnormal_innate_immunity1.65365536
40MP0002452_abnormal_antigen_presenting1.64838216
41MP0008961_abnormal_basal_metabolism1.62462105
42MP0002429_abnormal_blood_cell1.61866796
43MP0005000_abnormal_immune_tolerance1.58048083
44MP0004947_skin_inflammation1.57953973
45MP0001533_abnormal_skeleton_physiology1.55397651
46MP0005503_abnormal_tendon_morphology1.53959106
47MP0003191_abnormal_cellular_cholesterol1.52857089
48MP0000465_gastrointestinal_hemorrhage1.52584040
49MP0003436_decreased_susceptibility_to1.51697492
50MP0003172_abnormal_lysosome_physiology1.48547899
51MP0001873_stomach_inflammation1.48272742
52MP0005058_abnormal_lysosome_morphology1.44849685
53MP0003866_abnormal_defecation1.42392630
54MP0003566_abnormal_cell_adhesion1.39441804
55MP0002877_abnormal_melanocyte_morpholog1.36620097
56MP0000490_abnormal_crypts_of1.35931438
57MP0004858_abnormal_nervous_system1.33154327
58MP0009785_altered_susceptibility_to1.32397087
59MP0005076_abnormal_cell_differentiation1.30357206
60MP0001849_ear_inflammation1.29298417
61MP0005023_abnormal_wound_healing1.27459789
62MP0003453_abnormal_keratinocyte_physiol1.26553423
63MP0005083_abnormal_biliary_tract1.24626527
64MP0005025_abnormal_response_to1.23651787
65MP0004185_abnormal_adipocyte_glucose1.23117806
66MP0000678_abnormal_parathyroid_gland1.20585919
67MP0005375_adipose_tissue_phenotype1.17467968
68MP0003724_increased_susceptibility_to1.15907267
69MP0004381_abnormal_hair_follicle1.15658687
70MP0005666_abnormal_adipose_tissue1.15286443
71MP0003828_pulmonary_edema1.15234419
72MP0005390_skeleton_phenotype1.15209442
73MP0000733_abnormal_muscle_development1.13683424
74MP0002019_abnormal_tumor_incidence1.12860619
75MP0003077_abnormal_cell_cycle1.12490717
76MP0001348_abnormal_lacrimal_gland1.09909965
77MP0003091_abnormal_cell_migration1.09824650
78MP0010094_abnormal_chromosome_stability1.08345805
79MP0000003_abnormal_adipose_tissue1.07594662
80MP0001958_emphysema1.07572201
81MP0002060_abnormal_skin_morphology1.06696967
82* MP0002925_abnormal_cardiovascular_devel1.06603711
83MP0008438_abnormal_cutaneous_collagen1.06376103
84MP0001851_eye_inflammation1.03851190
85MP0002254_reproductive_system_inflammat1.02674495
86MP0009384_cardiac_valve_regurgitation1.02517631
87MP0003984_embryonic_growth_retardation1.02127360
88MP0000858_altered_metastatic_potential1.01850301
89MP0010630_abnormal_cardiac_muscle1.01569580
90MP0005464_abnormal_platelet_physiology1.01467076
91MP0000751_myopathy1.01294396
92MP0002088_abnormal_embryonic_growth/wei1.00801748
93MP0002796_impaired_skin_barrier1.00673469
94MP0000350_abnormal_cell_proliferation0.99666585
95MP0004957_abnormal_blastocyst_morpholog0.96919206
96MP0003111_abnormal_nucleus_morphology0.96751200
97MP0001730_embryonic_growth_arrest0.96108651
98MP0001243_abnormal_dermal_layer0.95613291
99MP0002086_abnormal_extraembryonic_tissu0.92377411
100MP0004084_abnormal_cardiac_muscle0.91705993
101MP0006082_CNS_inflammation0.91049528
102MP0001542_abnormal_bone_strength0.89706153
103MP0001845_abnormal_inflammatory_respons0.89455878
104MP0003448_altered_tumor_morphology0.88973068
105MP0006138_congestive_heart_failure0.88454595
106MP0001672_abnormal_embryogenesis/_devel0.88043823
107MP0005380_embryogenesis_phenotype0.88043823
108MP0008770_decreased_survivor_rate0.85246232
109MP0004510_myositis0.85124668
110MP0009840_abnormal_foam_cell0.84230133
111MP0004197_abnormal_fetal_growth/weight/0.82911833
112MP0005621_abnormal_cell_physiology0.81246975
113MP0008007_abnormal_cellular_replicative0.81108499
114MP0001853_heart_inflammation0.80817778
115MP0003795_abnormal_bone_structure0.80711469
116MP0005164_abnormal_response_to0.79550042
117* MP0002128_abnormal_blood_circulation0.79478556
118MP0002148_abnormal_hypersensitivity_rea0.78928777
119MP0008057_abnormal_DNA_replication0.78685409
120* MP0000266_abnormal_heart_morphology0.77153652
121MP0004272_abnormal_basement_membrane0.75378522
122MP0001915_intracranial_hemorrhage0.74027016
123* MP0001784_abnormal_fluid_regulation0.72941515
124* MP0002080_prenatal_lethality0.72328491
125MP0002998_abnormal_bone_remodeling0.71303420
126MP0000750_abnormal_muscle_regeneration0.71237053
127MP0000477_abnormal_intestine_morphology0.70165460
128MP0000313_abnormal_cell_death0.70095316
129* MP0001614_abnormal_blood_vessel0.69899112
130* MP0000767_abnormal_smooth_muscle0.69687839
131MP0004087_abnormal_muscle_fiber0.67051649
132MP0000249_abnormal_blood_vessel0.66157621
133MP0009931_abnormal_skin_appearance0.65894977
134MP0005409_darkened_coat_color0.65670520

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.59187002
2Panhypogammaglobulinemia (HP:0003139)5.31432371
3Abnormality of T cell number (HP:0011839)5.23548671
4B lymphocytopenia (HP:0010976)4.37370444
5Abnormality of B cell number (HP:0010975)4.37370444
6Recurrent viral infections (HP:0004429)4.24128865
7Severe combined immunodeficiency (HP:0004430)4.06855368
8Combined immunodeficiency (HP:0005387)4.03798141
9Eczematoid dermatitis (HP:0000976)3.68656934
10Abnormality of T cells (HP:0002843)3.64864356
11Thyroiditis (HP:0100646)3.45226061
12Abnormality of the fingertips (HP:0001211)3.35044391
13Abnormality of the nasal mucosa (HP:0000433)3.29013138
14Recurrent fungal infections (HP:0002841)3.23459222
15Papilloma (HP:0012740)3.14755825
16Verrucae (HP:0200043)3.14755825
17Obstructive sleep apnea (HP:0002870)3.12295126
18Hypoplasia of the thymus (HP:0000778)3.09835252
19Protrusio acetabuli (HP:0003179)3.09418525
20Recurrent bronchitis (HP:0002837)3.05329149
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.05079871
22Cellulitis (HP:0100658)3.04547413
23Eosinophilia (HP:0001880)3.00625780
24Agammaglobulinemia (HP:0004432)3.00557456
25Increased density of long bones (HP:0006392)2.94219390
26Chronic otitis media (HP:0000389)2.93918013
27Nasal polyposis (HP:0100582)2.90790147
28Cervical subluxation (HP:0003308)2.87386416
29Broad face (HP:0000283)2.86627285
30Spontaneous hematomas (HP:0007420)2.84052390
31Hyperacusis (HP:0010780)2.74936751
32Cerebral aneurysm (HP:0004944)2.71614790
33Increased variability in muscle fiber diameter (HP:0003557)2.64472351
34Aortic aneurysm (HP:0004942)2.55838663
35Granulocytopenia (HP:0001913)2.52939905
36Elevated erythrocyte sedimentation rate (HP:0003565)2.51620379
37Vascular tortuosity (HP:0004948)2.48409291
38Hypoproteinemia (HP:0003075)2.46301106
39Fragile skin (HP:0001030)2.40837122
40Ulnar bowing (HP:0003031)2.40386226
41Abnormality of skeletal muscle fiber size (HP:0012084)2.37609522
42IgM deficiency (HP:0002850)2.37096517
43Abnormality of eosinophils (HP:0001879)2.37062404
44Arterial tortuosity (HP:0005116)2.36538119
45Distal lower limb amyotrophy (HP:0008944)2.35622191
46Mitral regurgitation (HP:0001653)2.34377246
47Bicuspid aortic valve (HP:0001647)2.32782162
48Gastrointestinal inflammation (HP:0004386)2.31966344
49Leukocytosis (HP:0001974)2.31030574
50Biconcave vertebral bodies (HP:0004586)2.25115090
51Blue sclerae (HP:0000592)2.24936274
52Meningitis (HP:0001287)2.24841928
53Broad metatarsal (HP:0001783)2.22194998
54Recurrent abscess formation (HP:0002722)2.21854956
55Spondylolisthesis (HP:0003302)2.21581229
56Increased connective tissue (HP:0009025)2.21318854
57IgG deficiency (HP:0004315)2.21254184
58Spinal rigidity (HP:0003306)2.20369392
59Long eyelashes (HP:0000527)2.18093508
60Inflammation of the large intestine (HP:0002037)2.18074747
61Chronic mucocutaneous candidiasis (HP:0002728)2.15231138
62Recurrent cutaneous fungal infections (HP:0011370)2.15231138
63Atrophic scars (HP:0001075)2.14713406
64Basal cell carcinoma (HP:0002671)2.14651548
65Broad palm (HP:0001169)2.13778461
66Abnormality of macrophages (HP:0004311)2.13760207
67Mitral valve prolapse (HP:0001634)2.09263479
68Spinal cord lesions (HP:0100561)2.09017237
69Syringomyelia (HP:0003396)2.09017237
70Genu recurvatum (HP:0002816)2.08735299
71Vertebral compression fractures (HP:0002953)2.07553388
72Gingivitis (HP:0000230)2.06943693
73Short 4th metacarpal (HP:0010044)2.06540132
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06540132
75Thrombocytosis (HP:0001894)2.05497719
76Metaphyseal cupping (HP:0003021)2.05209833
77Abnormality of T cell physiology (HP:0011840)2.04360258
78Recurrent bacterial skin infections (HP:0005406)2.04327906
79Prolonged bleeding time (HP:0003010)2.03872923
80Joint laxity (HP:0001388)2.02846777
81Macroorchidism (HP:0000053)2.01895351
82Dilatation of the ascending aorta (HP:0005111)2.00595918
83Chest pain (HP:0100749)1.99914614
84Emphysema (HP:0002097)1.98350269
85Wormian bones (HP:0002645)1.97774802
86Nonimmune hydrops fetalis (HP:0001790)1.97452575
87Polycythemia (HP:0001901)1.97337098
88Aortic regurgitation (HP:0001659)1.97279296
89Aortic dissection (HP:0002647)1.95268326
90Ankle contracture (HP:0006466)1.94867945
91Centrally nucleated skeletal muscle fibers (HP:0003687)1.94736803
92Gastrointestinal infarctions (HP:0005244)1.94703577
93Interstitial pulmonary disease (HP:0006530)1.94208795
94Pustule (HP:0200039)1.94085119
95Persistence of primary teeth (HP:0006335)1.93462106
96Joint stiffness (HP:0001387)1.93419990
97Abnormal number of erythroid precursors (HP:0012131)1.91840635
98Polygenic inheritance (HP:0010982)1.91109598
99Obstructive lung disease (HP:0006536)1.89248586
100Chronic obstructive pulmonary disease (HP:0006510)1.89248586
101High pitched voice (HP:0001620)1.88153592
102Abnormality of cells of the erythroid lineage (HP:0012130)1.86826804
103Orchitis (HP:0100796)1.86820475
104Distal lower limb muscle weakness (HP:0009053)1.85577135
105Thin bony cortex (HP:0002753)1.85300335
106Cutis marmorata (HP:0000965)1.85165848
107Shallow orbits (HP:0000586)1.84135436
108Disproportionate tall stature (HP:0001519)1.83962098
109Autoimmune thrombocytopenia (HP:0001973)1.83828570
110Segmental peripheral demyelination/remyelination (HP:0003481)1.83448951
111Abnormality of the peritoneum (HP:0002585)1.81293413
112Lymphopenia (HP:0001888)1.81051736
113Hemorrhage of the eye (HP:0011885)1.80854854
114Chronic sinusitis (HP:0011109)1.80805054
115Aplasia/Hypoplasia of the thymus (HP:0010515)1.80507084
116Long palpebral fissure (HP:0000637)1.80432484
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.80044166
118Easy fatigability (HP:0003388)1.79701965
119Abnormality of oral frenula (HP:0000190)1.79444503
120Hematochezia (HP:0002573)1.78185291
121Bowel diverticulosis (HP:0005222)1.77998754
122Epistaxis (HP:0000421)1.75942386
123Colitis (HP:0002583)1.74829895
124Ankyloglossia (HP:0010296)1.74382023
125Mildly elevated creatine phosphokinase (HP:0008180)1.74366825
126Lymphoma (HP:0002665)1.72663590
127Dislocated radial head (HP:0003083)1.72328226
128Aneurysm (HP:0002617)1.72286540
129Lymphangioma (HP:0100764)1.72160055
130Abnormal platelet volume (HP:0011876)1.71637495
131Peritonitis (HP:0002586)1.71128480
132Premature skin wrinkling (HP:0100678)1.71094137
133Vertebral arch anomaly (HP:0008438)1.69831421
134Ectopia lentis (HP:0001083)1.69550248
135Skin tags (HP:0010609)1.69441243
136Myositis (HP:0100614)1.69357075
137Type 1 muscle fiber predominance (HP:0003803)1.68900751
138Increased nuchal translucency (HP:0010880)1.68743643
139Abnormal vertebral ossification (HP:0100569)1.68205102
140Bowing of the arm (HP:0006488)1.68021233
141Bowed forearm bones (HP:0003956)1.68021233
142Sparse lateral eyebrow (HP:0005338)1.67902920
143Premature rupture of membranes (HP:0001788)1.66940520
144Difficulty climbing stairs (HP:0003551)1.66194744
145Stridor (HP:0010307)1.65900180
146Increased IgE level (HP:0003212)1.65836319
147Distal upper limb amyotrophy (HP:0007149)1.65630392
148Upper limb amyotrophy (HP:0009129)1.65630392
149Gastrointestinal dysmotility (HP:0002579)1.64991126
150Slender build (HP:0001533)1.63796116
151Gastrointestinal stroma tumor (HP:0100723)1.63630077
152Abnormality of the radial head (HP:0003995)1.61191441
153Bladder diverticulum (HP:0000015)1.60889877
154Fatigue (HP:0012378)1.60760502
155Sepsis (HP:0100806)1.60401662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.21516465
2EEF2K4.18095710
3MAP3K104.06957762
4TRIB33.58395809
5PRPF4B3.35017413
6PKN23.13016169
7CDK122.94365570
8SMG12.89310945
9ERN12.59226840
10STK102.54303546
11ZAP702.39951916
12GRK62.26852404
13TXK2.07795093
14JAK32.07604909
15RIPK41.99498081
16TTN1.95594237
17LRRK21.89838233
18ITK1.79159507
19MAP3K131.76735277
20KDR1.71680683
21TGFBR21.67161908
22FGFR41.56963542
23SIK21.50503844
24TIE11.50496363
25FGFR31.46500792
26TGFBR11.39072196
27CDC42BPA1.36461678
28IRAK41.29896481
29PTK61.29277525
30BTK1.26551551
31MAP3K31.26451784
32MAP2K31.25390591
33MAP3K61.24443104
34CSF1R1.21792276
35SIK11.16581452
36HCK1.15262517
37TYK21.15163423
38CSK1.14675847
39RPS6KA41.14596493
40SYK1.14114427
41NEK21.12929609
42RPS6KB21.11614671
43IRAK31.11577190
44LCK1.10251721
45EPHB11.10090380
46MAP3K141.06926240
47NLK1.04415269
48CLK11.03841029
49PDGFRB1.02954532
50KSR21.02746742
51PRKCH1.02280787
52CDK41.01936917
53PDGFRA1.01457307
54MAP3K10.98826328
55DMPK0.97708729
56SIK30.96313763
57TAOK20.95804441
58* MARK20.89845544
59ALK0.89582148
60HIPK20.86217687
61RPS6KL10.85911736
62RPS6KA20.83891233
63JAK10.82447926
64KIT0.80950091
65NME20.80943492
66MAPK70.79368570
67PTK20.77301891
68TYRO30.76288599
69PAK20.76189205
70MTOR0.76003615
71IKBKE0.75827959
72RIPK10.74751764
73TEC0.73812494
74PASK0.73180098
75ILK0.73012104
76PAK40.72143857
77PIM10.72128147
78PRKD20.71676864
79TAOK10.71434949
80FGFR20.70569682
81PDPK10.69798498
82TNK20.69360185
83EPHA20.68472330
84FLT30.67424617
85CHUK0.64636069
86CDC70.63032003
87TBK10.61679914
88MARK30.61647892
89MAPK120.61609486
90BLK0.61473265
91STK380.60247956
92FES0.59715514
93BRD40.57781612
94STK40.56047632
95TESK10.54030302
96MAP3K80.53278782
97ICK0.53078517
98MAP2K20.52800124
99TRPM70.52738669
100PRKCQ0.52275751
101NTRK10.51211928
102CDK70.50687952
103JAK20.50098186
104MST1R0.49742329
105PDK10.48631714
106TESK20.48088582
107CDK60.47911355
108PRKD30.47708536
109MAPKAPK20.47292330
110PTK2B0.45569723
111IRAK20.44935198
112IKBKB0.43536313
113CAMK1G0.43229097
114FGFR10.43064416
115CHEK10.42711691
116PIM20.41542854
117CDK90.41201206
118MELK0.40730012
119FGR0.39653209
120BMX0.39050422
121CAMKK10.38424180
122CAMK40.38262062
123INSR0.37585632
124RPS6KA60.37247225
125* MAP3K70.36461407
126RET0.36115740
127WNK10.35498400
128MAP3K110.35347357
129LYN0.34599104
130PRKG20.32816744
131MAPK110.32287398
132RPS6KC10.31895759

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.86065499
2T cell receptor signaling pathway_Homo sapiens_hsa046602.66212143
3B cell receptor signaling pathway_Homo sapiens_hsa046622.12141536
4Chronic myeloid leukemia_Homo sapiens_hsa052201.98358651
5Acute myeloid leukemia_Homo sapiens_hsa052211.92525811
6Other glycan degradation_Homo sapiens_hsa005111.90296762
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83384564
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.80646346
9Measles_Homo sapiens_hsa051621.75935491
10Hematopoietic cell lineage_Homo sapiens_hsa046401.74445142
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72386385
12Antigen processing and presentation_Homo sapiens_hsa046121.68043172
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.58917438
14Viral myocarditis_Homo sapiens_hsa054161.58687085
15Ribosome_Homo sapiens_hsa030101.55375114
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50851339
17HTLV-I infection_Homo sapiens_hsa051661.50390042
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48757816
19Small cell lung cancer_Homo sapiens_hsa052221.47309687
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47089753
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46694365
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.43024287
23Osteoclast differentiation_Homo sapiens_hsa043801.38003914
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.36653890
25Platelet activation_Homo sapiens_hsa046111.35476464
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34143049
27DNA replication_Homo sapiens_hsa030301.32270107
28Non-homologous end-joining_Homo sapiens_hsa034501.31831490
29Pancreatic cancer_Homo sapiens_hsa052121.31525611
30Colorectal cancer_Homo sapiens_hsa052101.30718996
31Leishmaniasis_Homo sapiens_hsa051401.30460641
32Toxoplasmosis_Homo sapiens_hsa051451.28017766
33Herpes simplex infection_Homo sapiens_hsa051681.24251812
34Hepatitis B_Homo sapiens_hsa051611.23217270
35Non-small cell lung cancer_Homo sapiens_hsa052231.23125417
36MicroRNAs in cancer_Homo sapiens_hsa052061.20483846
37Notch signaling pathway_Homo sapiens_hsa043301.19765727
38Spliceosome_Homo sapiens_hsa030401.18910645
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.16932816
40Focal adhesion_Homo sapiens_hsa045101.16615323
41VEGF signaling pathway_Homo sapiens_hsa043701.16494792
42Thyroid cancer_Homo sapiens_hsa052161.13185430
43Shigellosis_Homo sapiens_hsa051311.13082140
44Base excision repair_Homo sapiens_hsa034101.12355445
45Proteoglycans in cancer_Homo sapiens_hsa052051.11548584
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09200139
47Endometrial cancer_Homo sapiens_hsa052131.03964527
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03135484
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.00472667
50Tuberculosis_Homo sapiens_hsa051520.99977254
51Apoptosis_Homo sapiens_hsa042100.95939063
52Cell cycle_Homo sapiens_hsa041100.95860760
53Chemokine signaling pathway_Homo sapiens_hsa040620.95839093
54GnRH signaling pathway_Homo sapiens_hsa049120.95271232
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94580425
56Lysine degradation_Homo sapiens_hsa003100.93055618
57* Viral carcinogenesis_Homo sapiens_hsa052030.92738504
58mTOR signaling pathway_Homo sapiens_hsa041500.92468080
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91913016
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91348053
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90913909
62Adherens junction_Homo sapiens_hsa045200.89124156
63Staphylococcus aureus infection_Homo sapiens_hsa051500.88905981
64Pathways in cancer_Homo sapiens_hsa052000.88230771
65mRNA surveillance pathway_Homo sapiens_hsa030150.88227855
66Prolactin signaling pathway_Homo sapiens_hsa049170.86307770
67Inositol phosphate metabolism_Homo sapiens_hsa005620.85702225
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84357445
69TNF signaling pathway_Homo sapiens_hsa046680.84019016
70Prostate cancer_Homo sapiens_hsa052150.83881575
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83587230
72Insulin signaling pathway_Homo sapiens_hsa049100.82788810
73ECM-receptor interaction_Homo sapiens_hsa045120.80038274
74Renal cell carcinoma_Homo sapiens_hsa052110.79045557
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78687389
76Mismatch repair_Homo sapiens_hsa034300.77244850
77Influenza A_Homo sapiens_hsa051640.76829256
78Rap1 signaling pathway_Homo sapiens_hsa040150.76749759
79HIF-1 signaling pathway_Homo sapiens_hsa040660.76680647
80RNA transport_Homo sapiens_hsa030130.75919977
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.75698952
82Estrogen signaling pathway_Homo sapiens_hsa049150.75601930
83Prion diseases_Homo sapiens_hsa050200.74153368
84Graft-versus-host disease_Homo sapiens_hsa053320.73270330
85p53 signaling pathway_Homo sapiens_hsa041150.73174884
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72431003
87Epstein-Barr virus infection_Homo sapiens_hsa051690.71998432
88Glioma_Homo sapiens_hsa052140.71260801
89Autoimmune thyroid disease_Homo sapiens_hsa053200.70057301
90Pertussis_Homo sapiens_hsa051330.69237192
91Allograft rejection_Homo sapiens_hsa053300.69143508
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.69004357
93Insulin resistance_Homo sapiens_hsa049310.68999386
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66840462
95Bladder cancer_Homo sapiens_hsa052190.65800886
96FoxO signaling pathway_Homo sapiens_hsa040680.64613830
97Dilated cardiomyopathy_Homo sapiens_hsa054140.64418969
98Malaria_Homo sapiens_hsa051440.64307314
99MAPK signaling pathway_Homo sapiens_hsa040100.63325294
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.62640237
101Dorso-ventral axis formation_Homo sapiens_hsa043200.61973984
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61763666
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59315954
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58679743
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58579919
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56615485
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56585027
108African trypanosomiasis_Homo sapiens_hsa051430.56451204
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56123562
110Endocytosis_Homo sapiens_hsa041440.55132499
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54924960
112Ras signaling pathway_Homo sapiens_hsa040140.54791329
113Hepatitis C_Homo sapiens_hsa051600.54245360
114Amoebiasis_Homo sapiens_hsa051460.53402639
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52230713
116Basal cell carcinoma_Homo sapiens_hsa052170.51675359
117Salmonella infection_Homo sapiens_hsa051320.51568332
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51397536
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.50401072
120RNA degradation_Homo sapiens_hsa030180.49334129
121One carbon pool by folate_Homo sapiens_hsa006700.48298456
122Choline metabolism in cancer_Homo sapiens_hsa052310.48072711
123ErbB signaling pathway_Homo sapiens_hsa040120.45175331

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