HDAC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.04258678
2vocalization behavior (GO:0071625)4.59239785
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46637508
4protein localization to synapse (GO:0035418)4.36817864
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35993353
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26084139
7pyrimidine nucleobase catabolic process (GO:0006208)4.24432615
8negative regulation of synaptic transmission, GABAergic (GO:0032229)4.18911652
9presynaptic membrane assembly (GO:0097105)4.05774734
10locomotory exploration behavior (GO:0035641)3.97054599
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93519212
12regulation of glutamate receptor signaling pathway (GO:1900449)3.88494284
13glutamate secretion (GO:0014047)3.87492098
14synaptic vesicle exocytosis (GO:0016079)3.82989465
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.71897831
16postsynaptic membrane organization (GO:0001941)3.70366702
17regulation of synaptic vesicle exocytosis (GO:2000300)3.69055735
18olfactory bulb development (GO:0021772)3.63836834
19presynaptic membrane organization (GO:0097090)3.63363561
20neurotransmitter-gated ion channel clustering (GO:0072578)3.63082359
21central nervous system neuron axonogenesis (GO:0021955)3.61923849
22neuron recognition (GO:0008038)3.58454162
23neural tube formation (GO:0001841)3.51173305
24glutamate receptor signaling pathway (GO:0007215)3.50905235
25synaptic vesicle maturation (GO:0016188)3.49743924
26retinal cone cell development (GO:0046549)3.44280795
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.43133533
28regulation of timing of cell differentiation (GO:0048505)3.42441020
29cerebral cortex radially oriented cell migration (GO:0021799)3.38077764
30exploration behavior (GO:0035640)3.35169519
31neuron-neuron synaptic transmission (GO:0007270)3.30072196
32startle response (GO:0001964)3.29162247
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27748266
34axonal fasciculation (GO:0007413)3.27300857
35nucleobase catabolic process (GO:0046113)3.26417356
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25161090
37regulation of sarcomere organization (GO:0060297)3.24439583
38limb bud formation (GO:0060174)3.24026931
39regulation of synaptic vesicle transport (GO:1902803)3.23576055
40synaptic transmission, glutamatergic (GO:0035249)3.22520149
41long-chain fatty acid biosynthetic process (GO:0042759)3.21773053
42protein polyglutamylation (GO:0018095)3.20108220
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18867642
44regulation of development, heterochronic (GO:0040034)3.18820210
45negative regulation of mast cell activation (GO:0033004)3.14891451
46dendritic spine morphogenesis (GO:0060997)3.14236630
47neuronal action potential propagation (GO:0019227)3.12913094
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10347747
49positive regulation of cardiac muscle cell differentiation (GO:2000727)3.09600824
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.08835265
51dentate gyrus development (GO:0021542)3.07770994
52regulation of meiosis I (GO:0060631)3.07555021
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06127235
54synaptic vesicle endocytosis (GO:0048488)3.04538760
55sympathetic nervous system development (GO:0048485)3.03887831
56gamma-aminobutyric acid transport (GO:0015812)3.03071771
57long-term memory (GO:0007616)2.99387748
58regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98174073
59regulation of postsynaptic membrane potential (GO:0060078)2.97329684
60behavioral response to nicotine (GO:0035095)2.97188049
61nonmotile primary cilium assembly (GO:0035058)2.96814012
62negative regulation of neurotransmitter transport (GO:0051589)2.96054471
63piRNA metabolic process (GO:0034587)2.94329495
64long-term synaptic potentiation (GO:0060291)2.93109812
65regulation of synaptic transmission, GABAergic (GO:0032228)2.92563490
66layer formation in cerebral cortex (GO:0021819)2.91736718
67regulation of neuronal synaptic plasticity (GO:0048168)2.91380469
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90276505
69cardiac chamber formation (GO:0003207)2.88911059
70neurotransmitter secretion (GO:0007269)2.86288815
71cardiac ventricle formation (GO:0003211)2.84919690
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84868184
73positive regulation of developmental pigmentation (GO:0048087)2.84594888
74positive regulation of membrane potential (GO:0045838)2.84141434
75regulation of synaptic transmission, glutamatergic (GO:0051966)2.83514537
76detection of calcium ion (GO:0005513)2.82288953
77central nervous system projection neuron axonogenesis (GO:0021952)2.81467121
78intraciliary transport (GO:0042073)2.81401051
79somite development (GO:0061053)2.79039268
80glycosphingolipid biosynthetic process (GO:0006688)2.79036228
81L-fucose catabolic process (GO:0042355)2.78607483
82fucose catabolic process (GO:0019317)2.78607483
83L-fucose metabolic process (GO:0042354)2.78607483
84synapse assembly (GO:0007416)2.78398871
85regulation of synapse maturation (GO:0090128)2.78226360
86regulation of neurotransmitter secretion (GO:0046928)2.77730888
87cilium morphogenesis (GO:0060271)2.77424858
88transmission of nerve impulse (GO:0019226)2.76421347
89L-amino acid import (GO:0043092)2.75422559
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74007864
91positive regulation of mitochondrial fission (GO:0090141)2.70812723
92proline transport (GO:0015824)2.70630233
93DNA double-strand break processing (GO:0000729)2.70615505
94response to histamine (GO:0034776)2.68996911
95regulation of synapse structural plasticity (GO:0051823)2.68383758
96regulation of pigment cell differentiation (GO:0050932)2.68096931
97forebrain neuron differentiation (GO:0021879)2.67539599
98righting reflex (GO:0060013)2.67158834
99retinal ganglion cell axon guidance (GO:0031290)2.66768665
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64458955
101regulation of cilium movement (GO:0003352)2.64132398
102dendrite morphogenesis (GO:0048813)2.62867328
103adult walking behavior (GO:0007628)2.61881549
104negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61380902
105positive regulation of neurotransmitter secretion (GO:0001956)2.60960051
106regulation of hippo signaling (GO:0035330)2.60953838
107membrane depolarization (GO:0051899)2.59927670
108serotonin receptor signaling pathway (GO:0007210)2.59773093
109epithelial cilium movement (GO:0003351)2.59509975
110regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.59080476
111neuron remodeling (GO:0016322)2.58973145
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58734110
113neurotransmitter transport (GO:0006836)2.58223280
114positive regulation of action potential (GO:0045760)2.58158383
115auditory behavior (GO:0031223)2.57537554
116dendrite development (GO:0016358)2.56437580
117mechanosensory behavior (GO:0007638)2.56129271
118membrane hyperpolarization (GO:0060081)2.56062961
119regulation of dendritic spine morphogenesis (GO:0061001)2.55933028
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54600080
121centriole replication (GO:0007099)2.54017021
122response to auditory stimulus (GO:0010996)2.53842677
123negative chemotaxis (GO:0050919)2.53219316
124learning (GO:0007612)2.53136322
125regulation of synaptic plasticity (GO:0048167)2.52992875
126regulation of voltage-gated calcium channel activity (GO:1901385)2.52815934
127regulation of synapse assembly (GO:0051963)2.52036362
128positive regulation of synapse assembly (GO:0051965)2.51777428
129regulation of penile erection (GO:0060405)2.51712346
130clathrin coat assembly (GO:0048268)2.51286251
131cerebral cortex cell migration (GO:0021795)2.51078853
132photoreceptor cell maintenance (GO:0045494)2.50943587
133cerebellar Purkinje cell differentiation (GO:0021702)2.50904654
134interkinetic nuclear migration (GO:0022027)2.50759045
135regulation of dendritic spine development (GO:0060998)2.50521071
136regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49544243
137inner ear receptor stereocilium organization (GO:0060122)2.48872022
138regulation of neurotransmitter transport (GO:0051588)2.47387775
139positive regulation of male gonad development (GO:2000020)2.46842505
140cilium organization (GO:0044782)2.46730394
141behavioral defense response (GO:0002209)2.46377656
142behavioral fear response (GO:0001662)2.46377656
143response to pheromone (GO:0019236)2.45989474
144neuron fate determination (GO:0048664)2.45277841
145cilium assembly (GO:0042384)2.44942173
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43950084
147regulation of cell communication by electrical coupling (GO:0010649)2.43756669
148innervation (GO:0060384)2.43344494
149regulation of platelet aggregation (GO:0090330)2.42675812
150membrane depolarization during action potential (GO:0086010)2.42205472
151membrane assembly (GO:0071709)2.42050151
152cornea development in camera-type eye (GO:0061303)2.41951851
153microtubule anchoring (GO:0034453)2.40967026
154positive regulation of synapse maturation (GO:0090129)2.40862011
155fear response (GO:0042596)2.40177915
156negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.39631788
157spermatid nucleus differentiation (GO:0007289)2.38710172
158vesicle transport along microtubule (GO:0047496)2.38668705
159appendage development (GO:0048736)2.38553846
160limb development (GO:0060173)2.38553846
161protein K11-linked deubiquitination (GO:0035871)2.37818122
162positive regulation of synaptic transmission, GABAergic (GO:0032230)2.37738847
163cell morphogenesis involved in neuron differentiation (GO:0048667)2.37630694
164negative regulation of oligodendrocyte differentiation (GO:0048715)2.36846839
165regulation of male gonad development (GO:2000018)2.36411200
166positive regulation of oligodendrocyte differentiation (GO:0048714)2.35696566
167monoubiquitinated protein deubiquitination (GO:0035520)2.34480756
168fibroblast migration (GO:0010761)2.34126154
169cilium or flagellum-dependent cell motility (GO:0001539)2.33949524
170calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33581524
171ganglion development (GO:0061548)2.33285234
172spinal cord development (GO:0021510)2.30577418
173reflex (GO:0060004)2.30391552
174cerebral cortex neuron differentiation (GO:0021895)2.29843520
175cellular component assembly involved in morphogenesis (GO:0010927)2.27937652
176negative regulation of astrocyte differentiation (GO:0048712)2.26155014
177regulation of relaxation of muscle (GO:1901077)2.26003994
178regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.25725011
179establishment of protein localization to Golgi (GO:0072600)2.25222045
180prenylation (GO:0097354)2.24467762
181protein prenylation (GO:0018342)2.24467762
182Notch signaling involved in heart development (GO:0061314)2.23995140
183glial cell proliferation (GO:0014009)2.23904369
184cell wall macromolecule catabolic process (GO:0016998)2.23718139
185nucleus localization (GO:0051647)2.23519468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73747536
2GBX2_23144817_ChIP-Seq_PC3_Human4.05169477
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78597259
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74469175
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.63874829
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56548955
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.35815398
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32461511
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29566490
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27897789
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27317742
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26875391
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26875391
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22399459
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.13860307
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12051733
17TAF15_26573619_Chip-Seq_HEK293_Human2.09407375
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02925421
19EWS_26573619_Chip-Seq_HEK293_Human2.01301287
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01153678
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00375884
22IGF1R_20145208_ChIP-Seq_DFB_Human1.91649011
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.91537221
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.90270278
25REST_21632747_ChIP-Seq_MESCs_Mouse1.90142935
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86793545
27DROSHA_22980978_ChIP-Seq_HELA_Human1.84457369
28AR_21572438_ChIP-Seq_LNCaP_Human1.83677606
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83623006
30* P300_19829295_ChIP-Seq_ESCs_Human1.82265791
31SMAD4_21799915_ChIP-Seq_A2780_Human1.81525008
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80972979
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78148270
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77276679
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75835031
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74612409
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73149244
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69719155
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68300537
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67088253
41CBP_20019798_ChIP-Seq_JUKART_Human1.67088253
42* SMAD_19615063_ChIP-ChIP_OVARY_Human1.65769261
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63107293
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.62987294
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61775958
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.61588110
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61445680
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58680089
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.58156995
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52721972
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51645305
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49117428
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48622751
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46699248
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46532143
56FUS_26573619_Chip-Seq_HEK293_Human1.43763516
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42714027
58BCAT_22108803_ChIP-Seq_LS180_Human1.41322187
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41088256
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39859851
61* AR_25329375_ChIP-Seq_VCAP_Human1.39723969
62STAT3_23295773_ChIP-Seq_U87_Human1.38426358
63VDR_22108803_ChIP-Seq_LS180_Human1.37392072
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37045543
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36641032
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.36250709
67ER_23166858_ChIP-Seq_MCF-7_Human1.35990566
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.35969808
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.33976632
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.32520709
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31977736
72IRF1_19129219_ChIP-ChIP_H3396_Human1.31724562
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.31124338
74RNF2_27304074_Chip-Seq_NSC_Mouse1.30912532
75AHR_22903824_ChIP-Seq_MCF-7_Human1.30622308
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30258400
77* TCF4_23295773_ChIP-Seq_U87_Human1.29761008
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29644442
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24561877
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24145265
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22273300
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.20194931
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19628001
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.19058086
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18965575
86TCF4_22108803_ChIP-Seq_LS180_Human1.18860859
87* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18668795
88* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18659214
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.17797181
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17385567
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16470913
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16370454
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16034530
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.15429703
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15392807
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14489892
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13019990
98NANOG_19829295_ChIP-Seq_ESCs_Human1.12542913
99SOX2_19829295_ChIP-Seq_ESCs_Human1.12542913
100P53_22387025_ChIP-Seq_ESCs_Mouse1.12108789
101* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12105746
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.12075199
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11163065
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11163065
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10266549
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10266549
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.09448517
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09029686
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07970668
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.07774998
111JUN_21703547_ChIP-Seq_K562_Human1.07350427
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06915691
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06863878
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.06069923
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06034386
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05563045
117SOX9_26525672_Chip-Seq_HEART_Mouse1.05463034
118KDM2B_26808549_Chip-Seq_REH_Human1.05377145
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04950683
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03917131
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03749396
122* TP53_18474530_ChIP-ChIP_U2OS_Human1.03621382
123AR_19668381_ChIP-Seq_PC3_Human1.03541414
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.03134211
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02851254
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.02533013
127* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01600441
128ZNF274_21170338_ChIP-Seq_K562_Hela1.00748518
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00404049
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00162293
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99599039
132* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98854714
133* TP53_16413492_ChIP-PET_HCT116_Human0.98490053
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98314654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.76505795
2MP0003880_abnormal_central_pattern4.46969859
3MP0003635_abnormal_synaptic_transmissio3.30785105
4MP0004270_analgesia2.97190352
5MP0005423_abnormal_somatic_nervous2.93990333
6MP0009745_abnormal_behavioral_response2.89237319
7MP0009046_muscle_twitch2.67175607
8MP0002063_abnormal_learning/memory/cond2.65746609
9MP0002064_seizures2.64293122
10MP0001968_abnormal_touch/_nociception2.61767075
11MP0001486_abnormal_startle_reflex2.58924586
12MP0008877_abnormal_DNA_methylation2.58837009
13MP0002735_abnormal_chemical_nociception2.45610377
14MP0002572_abnormal_emotion/affect_behav2.43444527
15MP0009780_abnormal_chondrocyte_physiolo2.29304874
16MP0002734_abnormal_mechanical_nocicepti2.28852807
17MP0002272_abnormal_nervous_system2.28454974
18MP0001188_hyperpigmentation2.17755070
19MP0004084_abnormal_cardiac_muscle2.17169594
20MP0002751_abnormal_autonomic_nervous2.12969882
21MP0002736_abnormal_nociception_after2.05711729
22MP0005645_abnormal_hypothalamus_physiol2.05443915
23MP0002653_abnormal_ependyma_morphology2.04921351
24MP0000778_abnormal_nervous_system2.04602366
25MP0003787_abnormal_imprinting1.99696563
26MP0005551_abnormal_eye_electrophysiolog1.94136434
27MP0002067_abnormal_sensory_capabilities1.85771446
28MP0008789_abnormal_olfactory_epithelium1.84154736
29MP0006276_abnormal_autonomic_nervous1.80527959
30MP0005409_darkened_coat_color1.79096881
31MP0005646_abnormal_pituitary_gland1.72140678
32MP0001970_abnormal_pain_threshold1.69571360
33MP0002733_abnormal_thermal_nociception1.67808420
34MP0001501_abnormal_sleep_pattern1.65727776
35MP0001440_abnormal_grooming_behavior1.64692988
36MP0002822_catalepsy1.64686843
37MP0002184_abnormal_innervation1.64555049
38MP0002557_abnormal_social/conspecific_i1.60315596
39MP0001984_abnormal_olfaction1.59434640
40MP0002234_abnormal_pharynx_morphology1.56638050
41MP0004924_abnormal_behavior1.50915145
42MP0005386_behavior/neurological_phenoty1.50915145
43MP0003879_abnormal_hair_cell1.49141410
44MP0001905_abnormal_dopamine_level1.44012806
45MP0004885_abnormal_endolymph1.43568023
46MP0000569_abnormal_digit_pigmentation1.43031597
47MP0005499_abnormal_olfactory_system1.42356700
48MP0005394_taste/olfaction_phenotype1.42356700
49MP0004036_abnormal_muscle_relaxation1.39249289
50MP0008569_lethality_at_weaning1.35267390
51MP0002882_abnormal_neuron_morphology1.34484100
52MP0003890_abnormal_embryonic-extraembry1.33668991
53MP0003121_genomic_imprinting1.31915793
54MP0004742_abnormal_vestibular_system1.31109110
55MP0004811_abnormal_neuron_physiology1.30633498
56MP0006292_abnormal_olfactory_placode1.29835144
57MP0003718_maternal_effect1.29359489
58MP0001986_abnormal_taste_sensitivity1.29287021
59MP0002909_abnormal_adrenal_gland1.27457442
60MP0001502_abnormal_circadian_rhythm1.24046476
61MP0005171_absent_coat_pigmentation1.21607488
62MP0000955_abnormal_spinal_cord1.19610796
63MP0004510_myositis1.19601621
64MP0004145_abnormal_muscle_electrophysio1.19043122
65MP0000015_abnormal_ear_pigmentation1.16097044
66MP0002066_abnormal_motor_capabilities/c1.15976993
67MP0001963_abnormal_hearing_physiology1.15575151
68MP0002233_abnormal_nose_morphology1.15569221
69MP0003950_abnormal_plasma_membrane1.15530892
70MP0000427_abnormal_hair_cycle1.15047473
71MP0002229_neurodegeneration1.11275297
72MP0004484_altered_response_of1.11089373
73MP0010386_abnormal_urinary_bladder1.09670359
74MP0002928_abnormal_bile_duct1.09268110
75MP0005620_abnormal_muscle_contractility1.08894154
76MP0004142_abnormal_muscle_tone1.08497283
77MP0000920_abnormal_myelination1.07832713
78MP0002876_abnormal_thyroid_physiology1.07803879
79MP0008775_abnormal_heart_ventricle1.07007718
80MP0004085_abnormal_heartbeat1.06731948
81MP0003633_abnormal_nervous_system1.06252741
82MP0003755_abnormal_palate_morphology1.04663194
83MP0005253_abnormal_eye_physiology1.02422208
84MP0002102_abnormal_ear_morphology1.01958365
85MP0005174_abnormal_tail_pigmentation1.01921773
86MP0006072_abnormal_retinal_apoptosis1.01789280
87MP0002837_dystrophic_cardiac_calcinosis1.01524611
88MP0003136_yellow_coat_color1.00734217
89MP0000049_abnormal_middle_ear1.00645576
90MP0002752_abnormal_somatic_nervous0.98843150
91MP0003631_nervous_system_phenotype0.98248780
92MP0002638_abnormal_pupillary_reflex0.98074373
93MP0005187_abnormal_penis_morphology0.96097925
94MP0004215_abnormal_myocardial_fiber0.95409526
95MP0000631_abnormal_neuroendocrine_gland0.94634155
96MP0003937_abnormal_limbs/digits/tail_de0.92413418
97MP0003690_abnormal_glial_cell0.90199097
98MP0000026_abnormal_inner_ear0.88592606
99MP0001879_abnormal_lymphatic_vessel0.88528121
100MP0000372_irregular_coat_pigmentation0.88424985
101MP0003646_muscle_fatigue0.86706437
102MP0002127_abnormal_cardiovascular_syste0.86144580
103MP0003329_amyloid_beta_deposits0.85816424
104MP0002152_abnormal_brain_morphology0.85814328
105MP0003634_abnormal_glial_cell0.85780432
106MP0008058_abnormal_DNA_repair0.84879643
107MP0005391_vision/eye_phenotype0.83880295
108MP0002095_abnormal_skin_pigmentation0.83125337
109MP0003632_abnormal_nervous_system0.83065936
110MP0000647_abnormal_sebaceous_gland0.82680448
111MP0002090_abnormal_vision0.82127897
112MP0000534_abnormal_ureter_morphology0.81672715
113MP0001485_abnormal_pinna_reflex0.80850358
114MP0005195_abnormal_posterior_eye0.80559522
115MP0001529_abnormal_vocalization0.80308109
116MP0000516_abnormal_urinary_system0.79573521
117MP0005367_renal/urinary_system_phenotyp0.79573521
118MP0000751_myopathy0.78249409
119MP0005395_other_phenotype0.77752553
120MP0001929_abnormal_gametogenesis0.76525909
121MP0003137_abnormal_impulse_conducting0.76496216
122MP0004134_abnormal_chest_morphology0.75542898
123MP0003122_maternal_imprinting0.74264563
124MP0003861_abnormal_nervous_system0.74157700
125MP0003183_abnormal_peptide_metabolism0.73662324
126MP0001177_atelectasis0.72680552
127MP0003938_abnormal_ear_development0.71082295
128MP0005623_abnormal_meninges_morphology0.70366795
129MP0009697_abnormal_copulation0.66598123
130MP0008874_decreased_physiological_sensi0.65295402
131MP0004858_abnormal_nervous_system0.64878852
132MP0005379_endocrine/exocrine_gland_phen0.64703118
133MP0002972_abnormal_cardiac_muscle0.62771387
134MP0003172_abnormal_lysosome_physiology0.61710098
135MP0002069_abnormal_eating/drinking_beha0.60382271

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.10718844
2Febrile seizures (HP:0002373)5.31494128
3Epileptic encephalopathy (HP:0200134)4.78794698
4Hyperventilation (HP:0002883)4.54497944
5Focal seizures (HP:0007359)4.26972997
6Atonic seizures (HP:0010819)3.97577621
7Progressive cerebellar ataxia (HP:0002073)3.86459388
8Myokymia (HP:0002411)3.73580503
9Broad-based gait (HP:0002136)3.68032180
10Pancreatic cysts (HP:0001737)3.56427410
11True hermaphroditism (HP:0010459)3.26850930
12Congenital stationary night blindness (HP:0007642)3.21908033
13Abnormality of midbrain morphology (HP:0002418)3.16000666
14Molar tooth sign on MRI (HP:0002419)3.16000666
15Absent speech (HP:0001344)3.14430095
16Drooling (HP:0002307)3.13541335
17Excessive salivation (HP:0003781)3.13541335
18Visual hallucinations (HP:0002367)3.10273901
19Pancreatic fibrosis (HP:0100732)3.08960496
20Generalized tonic-clonic seizures (HP:0002069)3.06227741
21Nephronophthisis (HP:0000090)2.98343648
22Absence seizures (HP:0002121)2.95238186
23Chronic hepatic failure (HP:0100626)2.92329284
24Widely spaced teeth (HP:0000687)2.83110427
25Dialeptic seizures (HP:0011146)2.80987680
26Genital tract atresia (HP:0001827)2.78332328
27Volvulus (HP:0002580)2.76047832
28Mutism (HP:0002300)2.74344941
29Gaze-evoked nystagmus (HP:0000640)2.68650531
30Vaginal atresia (HP:0000148)2.66930202
31Intestinal atresia (HP:0011100)2.65644438
32Supranuclear gaze palsy (HP:0000605)2.64662042
33Limb dystonia (HP:0002451)2.64396031
34Progressive inability to walk (HP:0002505)2.64069983
35Abnormality of the renal medulla (HP:0100957)2.61183456
36Blue irides (HP:0000635)2.60116046
37Fetal akinesia sequence (HP:0001989)2.57421853
38Poor eye contact (HP:0000817)2.56053794
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.53734792
40Inappropriate behavior (HP:0000719)2.49751739
41Genetic anticipation (HP:0003743)2.48946667
42Inability to walk (HP:0002540)2.48546445
43Protruding tongue (HP:0010808)2.46667491
44Urinary bladder sphincter dysfunction (HP:0002839)2.46392127
45Abnormality of salivation (HP:0100755)2.42536093
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.34964817
47Absent/shortened dynein arms (HP:0200106)2.34964817
48Abnormality of binocular vision (HP:0011514)2.34953693
49Diplopia (HP:0000651)2.34953693
50Papillary thyroid carcinoma (HP:0002895)2.33717580
51Gait imbalance (HP:0002141)2.33544209
52Abnormality of the corticospinal tract (HP:0002492)2.32720350
53Postaxial hand polydactyly (HP:0001162)2.32074221
54Ankle clonus (HP:0011448)2.32007429
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.29288464
56Truncal ataxia (HP:0002078)2.29153814
57Polyphagia (HP:0002591)2.28278915
58Abnormality of the labia minora (HP:0012880)2.26425270
59Action tremor (HP:0002345)2.26402542
60Abnormal hair whorl (HP:0010721)2.24788608
61Thyroiditis (HP:0100646)2.24745091
62Bony spicule pigmentary retinopathy (HP:0007737)2.24433966
63Oligodactyly (hands) (HP:0001180)2.20507788
64Neurofibrillary tangles (HP:0002185)2.19609354
65Dysmetria (HP:0001310)2.18069563
66Broad foot (HP:0001769)2.14641465
67Generalized hypopigmentation of hair (HP:0011358)2.13704250
68Amyotrophic lateral sclerosis (HP:0007354)2.13179174
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.12466546
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12466546
71Abnormal rod and cone electroretinograms (HP:0008323)2.11948172
72Abnormality of the renal cortex (HP:0011035)2.11863249
73Aqueductal stenosis (HP:0002410)2.11425315
74Poor coordination (HP:0002370)2.10996572
75Abnormality of macular pigmentation (HP:0008002)2.10828817
76Absent eyebrow (HP:0002223)2.10530388
77Impaired social interactions (HP:0000735)2.10251437
78Abnormal social behavior (HP:0012433)2.10251437
79Optic nerve hypoplasia (HP:0000609)2.08833065
80Abnormality of the metopic suture (HP:0005556)2.07827393
81Central scotoma (HP:0000603)2.07090157
82Retinal dysplasia (HP:0007973)2.06623874
83Thyroid-stimulating hormone excess (HP:0002925)2.06527162
84Dyschromatopsia (HP:0007641)2.04323355
85Papilledema (HP:0001085)2.03330013
86Narrow forehead (HP:0000341)2.03180104
87Thickened helices (HP:0000391)2.01697784
88Adactyly (HP:0009776)2.00536356
89Dysdiadochokinesis (HP:0002075)2.00353002
90Fair hair (HP:0002286)1.99560938
91Short foot (HP:0001773)1.99009221
92Astrocytoma (HP:0009592)1.97568603
93Abnormality of the astrocytes (HP:0100707)1.97568603
94Abnormal eating behavior (HP:0100738)1.97283793
95Clumsiness (HP:0002312)1.97088191
96Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96554852
97Specific learning disability (HP:0001328)1.95065635
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94920554
99Anencephaly (HP:0002323)1.94403833
100Medial flaring of the eyebrow (HP:0010747)1.94005269
101Stereotypic behavior (HP:0000733)1.93832071
102Methylmalonic acidemia (HP:0002912)1.93783635
103Thyroid carcinoma (HP:0002890)1.93486552
104Scanning speech (HP:0002168)1.93441098
105Impaired vibration sensation in the lower limbs (HP:0002166)1.93428299
106Attenuation of retinal blood vessels (HP:0007843)1.93257136
107Prolonged QT interval (HP:0001657)1.92827630
108Gastroesophageal reflux (HP:0002020)1.90290947
109Lissencephaly (HP:0001339)1.89824736
110Hypoplastic nipples (HP:0002557)1.89744390
111Glioma (HP:0009733)1.89483183
112Atrial fibrillation (HP:0005110)1.88816446
113Exotropia (HP:0000577)1.88346543
114Astigmatism (HP:0000483)1.88206461
115Renal hypoplasia (HP:0000089)1.87987974
116Cerebral inclusion bodies (HP:0100314)1.87192686
117Epileptiform EEG discharges (HP:0011182)1.86402940
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.86023506
119Postaxial foot polydactyly (HP:0001830)1.85920866
120Lower limb amyotrophy (HP:0007210)1.85344733
121Hypoplastic iliac wings (HP:0002866)1.84751377
122Vitreoretinal degeneration (HP:0000655)1.84155271
123Septo-optic dysplasia (HP:0100842)1.83709388
124Amblyopia (HP:0000646)1.81199684
125Anxiety (HP:0000739)1.80862399
126Abolished electroretinogram (ERG) (HP:0000550)1.80380458
127Nephrogenic diabetes insipidus (HP:0009806)1.80102035
128Primary atrial arrhythmia (HP:0001692)1.79571717
129Hypoplastic ischia (HP:0003175)1.79139178
130Cystic liver disease (HP:0006706)1.78821280
131Renal cortical cysts (HP:0000803)1.78512835
132Decreased circulating renin level (HP:0003351)1.78182637
133Decreased central vision (HP:0007663)1.78172982
134Short tibia (HP:0005736)1.77722266
135Spastic gait (HP:0002064)1.77548207
136Parakeratosis (HP:0001036)1.76256514
137Congenital hepatic fibrosis (HP:0002612)1.75974223
138Hypoproteinemia (HP:0003075)1.75833318
139Truncal obesity (HP:0001956)1.75605894
140EEG with generalized epileptiform discharges (HP:0011198)1.75107594
141Congenital primary aphakia (HP:0007707)1.74993607
142Congenital sensorineural hearing impairment (HP:0008527)1.74646829
143Depression (HP:0000716)1.73859503
144Left ventricular hypertrophy (HP:0001712)1.73770233
145Abnormal EKG (HP:0003115)1.73448555
146Akinesia (HP:0002304)1.73283415
147Agitation (HP:0000713)1.72811018
148Tubulointerstitial nephritis (HP:0001970)1.72424075
149Prominent nasal bridge (HP:0000426)1.72278361
150Agammaglobulinemia (HP:0004432)1.70829345
151Postural instability (HP:0002172)1.70659290
152Generalized myoclonic seizures (HP:0002123)1.70113747
153Rimmed vacuoles (HP:0003805)1.69957033
154Muscle hypertrophy of the lower extremities (HP:0008968)1.69753935
155Tented upper lip vermilion (HP:0010804)1.69572585
156Abnormality of the ischium (HP:0003174)1.68737468
157Obstructive sleep apnea (HP:0002870)1.68635452
158Hemiparesis (HP:0001269)1.68455572
159Colon cancer (HP:0003003)1.67929222
160Hypsarrhythmia (HP:0002521)1.67649731
161Split foot (HP:0001839)1.67523808
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66653566
163Sclerocornea (HP:0000647)1.65502116
164Preaxial hand polydactyly (HP:0001177)1.65265416
165Abnormality of the antihelix (HP:0009738)1.64873213
166Gastrointestinal atresia (HP:0002589)1.64641888
167Type II lissencephaly (HP:0007260)1.63523785
168Long nose (HP:0003189)1.63128528
169Abnormal ciliary motility (HP:0012262)1.62720347
170Prominent metopic ridge (HP:0005487)1.62660360
171Medulloblastoma (HP:0002885)1.61934061
172Abnormality of the pubic bones (HP:0003172)1.61623000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29150171
2FRK4.22422487
3MARK14.09980214
4MAP2K73.40674996
5NTRK33.15074613
6WNK32.92943929
7EPHA42.83904493
8TRIM282.80627751
9BCR2.62775436
10MAP4K22.31317396
11MAP3K42.21458126
12TNIK1.94511889
13SIK21.87702639
14PRPF4B1.83579892
15PNCK1.83390948
16PLK21.82171978
17MAP3K91.75850345
18NUAK11.75093552
19MAPK131.71305692
20GRK51.61014861
21MINK11.56130541
22NTRK21.55296089
23PHKG11.51573281
24PHKG21.51573281
25AKT31.46833724
26RIPK41.45046013
27MAP3K121.44095326
28CAMK1G1.37351952
29EPHA31.34649070
30CSNK1G11.31036051
31* PKN11.24560479
32NEK61.23723650
33EIF2AK31.21943667
34SGK21.21082915
35SGK2231.20363451
36SGK4941.20363451
37DAPK21.19765822
38MUSK1.19488623
39FES1.19047261
40STK38L1.18005054
41ACVR1B1.16788798
42GRK71.15409850
43SIK31.15062839
44PRKCE1.13079931
45CDK51.12881612
46INSRR1.12807297
47MAP3K61.12645999
48CAMK2A1.11655400
49MAP2K41.07215594
50PIK3CG1.06955701
51MAPK121.03822342
52ZAK1.03344655
53DYRK1A1.02432699
54MKNK21.00498721
55OXSR10.99945473
56BMPR20.99154347
57PAK60.98473123
58GRK10.96917890
59CDK190.95131269
60CSNK1G20.93494937
61PRKCG0.90636374
62SRPK10.84921411
63BRSK20.84253461
64NTRK10.83841419
65FGR0.83685649
66BMPR1B0.82188369
67TIE10.81875113
68CCNB10.81842555
69UHMK10.81469172
70STK390.81288003
71CAMK2B0.80342074
72CDK80.79526235
73SGK10.77449358
74TAOK30.77295414
75IRAK10.75455011
76CDK30.72706584
77FLT30.72681345
78DYRK20.72555461
79ROCK10.71928923
80STK110.71136304
81MAPK70.71080980
82SGK30.71043404
83CAMK2D0.70908358
84MARK20.67849555
85CSNK1A1L0.66715427
86CAMKK10.66437116
87ADRBK20.66426239
88PIK3CA0.65893178
89ERBB30.65844567
90TLK10.65546033
91PRKCH0.64898780
92CSF1R0.64393785
93VRK10.62360309
94MAP3K130.61180014
95CAMKK20.60949153
96MET0.59237469
97CSNK1G30.59201078
98* CAMK10.58477240
99NEK90.58435987
100EIF2AK20.58359253
101TNK20.58080380
102CAMK40.58040380
103FYN0.57579103
104MAP3K50.55666286
105PRKG10.55284265
106STK380.55057025
107YES10.53251273
108MAPKAPK50.53049383
109DYRK1B0.52161100
110CLK10.51817690
111MAP3K100.51811709
112NLK0.51532023
113CSNK1D0.49700349
114PDK10.49018668
115PRKCZ0.48788935
116DAPK10.48023295
117STK30.47950103
118PRKCQ0.47819793
119PTK2B0.47744103
120SYK0.46572102
121PRKAA10.46493566
122PDK20.45211211
123MAP3K70.44336073
124OBSCN0.44087823
125ADRBK10.44045433
126MAP3K140.43834249
127EGFR0.43566215
128IRAK20.43109659
129FER0.43046959
130ROCK20.42748743
131MKNK10.41523659
132TXK0.40883069
133BRD40.40881658
134RPS6KA20.40875413
135EPHB20.40391252
136IRAK40.39649990
137PAK30.38682823
138MST40.37856049
139PINK10.37784536
140KSR10.36854687
141CSNK1A10.36833149
142TEC0.36563757
143PRKACB0.36382671
144RPS6KA30.36312345

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.27747103
2Phototransduction_Homo sapiens_hsa047442.69480751
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58328050
4Morphine addiction_Homo sapiens_hsa050322.48521475
5GABAergic synapse_Homo sapiens_hsa047272.46313305
6Synaptic vesicle cycle_Homo sapiens_hsa047212.37502820
7Olfactory transduction_Homo sapiens_hsa047402.37297874
8Glutamatergic synapse_Homo sapiens_hsa047242.36298673
9Circadian entrainment_Homo sapiens_hsa047132.35403370
10Fanconi anemia pathway_Homo sapiens_hsa034602.14152900
11Serotonergic synapse_Homo sapiens_hsa047262.08288103
12Basal transcription factors_Homo sapiens_hsa030222.04790409
13Asthma_Homo sapiens_hsa053101.90413812
14Salivary secretion_Homo sapiens_hsa049701.89776148
15Long-term potentiation_Homo sapiens_hsa047201.89417383
16Taste transduction_Homo sapiens_hsa047421.83123833
17Cholinergic synapse_Homo sapiens_hsa047251.81059276
18Dopaminergic synapse_Homo sapiens_hsa047281.78282629
19Amphetamine addiction_Homo sapiens_hsa050311.77637489
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.69593587
21Propanoate metabolism_Homo sapiens_hsa006401.68636291
22Insulin secretion_Homo sapiens_hsa049111.66287826
23Renin secretion_Homo sapiens_hsa049241.63696997
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58577171
25Long-term depression_Homo sapiens_hsa047301.56244259
26Regulation of autophagy_Homo sapiens_hsa041401.55670529
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54627543
28Butanoate metabolism_Homo sapiens_hsa006501.53241932
29Calcium signaling pathway_Homo sapiens_hsa040201.52977517
30Oxytocin signaling pathway_Homo sapiens_hsa049211.45317852
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43715476
32Gastric acid secretion_Homo sapiens_hsa049711.43696918
33Axon guidance_Homo sapiens_hsa043601.41091132
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40816873
35Non-homologous end-joining_Homo sapiens_hsa034501.40443556
36Cocaine addiction_Homo sapiens_hsa050301.30339729
37Collecting duct acid secretion_Homo sapiens_hsa049661.28995513
38Protein export_Homo sapiens_hsa030601.23236348
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22568642
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19875894
41Homologous recombination_Homo sapiens_hsa034401.18892576
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17127333
43cAMP signaling pathway_Homo sapiens_hsa040241.15706777
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14755090
45Systemic lupus erythematosus_Homo sapiens_hsa053221.14748317
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14428346
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13872011
48Dilated cardiomyopathy_Homo sapiens_hsa054141.13460672
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10949894
50Oocyte meiosis_Homo sapiens_hsa041141.07409087
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07333567
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07031723
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.06733258
54Nitrogen metabolism_Homo sapiens_hsa009101.04386084
55GnRH signaling pathway_Homo sapiens_hsa049121.02087129
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01474530
57Type II diabetes mellitus_Homo sapiens_hsa049301.00570186
58Gap junction_Homo sapiens_hsa045401.00068890
59Graft-versus-host disease_Homo sapiens_hsa053320.99464864
60Autoimmune thyroid disease_Homo sapiens_hsa053200.94842510
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93015497
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92219485
63ErbB signaling pathway_Homo sapiens_hsa040120.90004439
64Allograft rejection_Homo sapiens_hsa053300.90003724
65Cardiac muscle contraction_Homo sapiens_hsa042600.88337263
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87360287
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86433060
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86406374
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84343350
70Ras signaling pathway_Homo sapiens_hsa040140.82992053
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82683004
72RNA degradation_Homo sapiens_hsa030180.81762822
73Glioma_Homo sapiens_hsa052140.81686808
74Estrogen signaling pathway_Homo sapiens_hsa049150.81037045
75Melanogenesis_Homo sapiens_hsa049160.80001721
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78636489
77MAPK signaling pathway_Homo sapiens_hsa040100.78526439
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78422742
79Chemokine signaling pathway_Homo sapiens_hsa040620.78069709
80Vibrio cholerae infection_Homo sapiens_hsa051100.77325933
81Pancreatic secretion_Homo sapiens_hsa049720.76611843
82Ether lipid metabolism_Homo sapiens_hsa005650.76498871
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75682331
84Rheumatoid arthritis_Homo sapiens_hsa053230.75523144
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74719875
86Hedgehog signaling pathway_Homo sapiens_hsa043400.74162862
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73592650
88Viral myocarditis_Homo sapiens_hsa054160.73467401
89Steroid biosynthesis_Homo sapiens_hsa001000.72543006
90ABC transporters_Homo sapiens_hsa020100.72160791
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.72004109
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70777490
93Dorso-ventral axis formation_Homo sapiens_hsa043200.69732893
94Choline metabolism in cancer_Homo sapiens_hsa052310.69509567
95Ovarian steroidogenesis_Homo sapiens_hsa049130.68370812
96TGF-beta signaling pathway_Homo sapiens_hsa043500.68086926
97B cell receptor signaling pathway_Homo sapiens_hsa046620.66885161
98Rap1 signaling pathway_Homo sapiens_hsa040150.65942664
99Lysine degradation_Homo sapiens_hsa003100.65900526
100Hippo signaling pathway_Homo sapiens_hsa043900.65689993
101African trypanosomiasis_Homo sapiens_hsa051430.63760518
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.61281335
103FoxO signaling pathway_Homo sapiens_hsa040680.60494112
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59702682
105Linoleic acid metabolism_Homo sapiens_hsa005910.58840368
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57967371
107Sphingolipid metabolism_Homo sapiens_hsa006000.56990623
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56238646
109Type I diabetes mellitus_Homo sapiens_hsa049400.54334580
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53854127
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53225209
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52638359
113Tryptophan metabolism_Homo sapiens_hsa003800.51501876
114Phagosome_Homo sapiens_hsa041450.50160332
115Renal cell carcinoma_Homo sapiens_hsa052110.48431784
116* Alcoholism_Homo sapiens_hsa050340.46865916
117Wnt signaling pathway_Homo sapiens_hsa043100.46124998
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46101532
119Inositol phosphate metabolism_Homo sapiens_hsa005620.45905199
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44995401
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44925641
122Tuberculosis_Homo sapiens_hsa051520.44255852
123Cell cycle_Homo sapiens_hsa041100.44043094
124Thyroid hormone synthesis_Homo sapiens_hsa049180.41440911
125Melanoma_Homo sapiens_hsa052180.41132767
126Alzheimers disease_Homo sapiens_hsa050100.40700296
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.40347084
128Nucleotide excision repair_Homo sapiens_hsa034200.39290032
129Platelet activation_Homo sapiens_hsa046110.38982440
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37865238
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37537310
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36122719
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36011470
134Osteoclast differentiation_Homo sapiens_hsa043800.34094215
135Circadian rhythm_Homo sapiens_hsa047100.33771386
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33651765
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33634175
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33374033
139Salmonella infection_Homo sapiens_hsa051320.33189416
140Primary immunodeficiency_Homo sapiens_hsa053400.32301096

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