HDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell cytokine production (GO:0002724)9.80793458
2T cell apoptotic process (GO:0070231)9.02254057
3regulation of dendritic cell antigen processing and presentation (GO:0002604)8.48681441
4positive regulation of leukocyte degranulation (GO:0043302)8.39432713
5angiotensin maturation (GO:0002003)8.04306930
6lymphocyte apoptotic process (GO:0070227)7.71040184
7leukocyte apoptotic process (GO:0071887)6.63482799
8neutrophil mediated immunity (GO:0002446)6.48973684
9disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.43781943
10killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.43781943
11positive regulation of antigen processing and presentation (GO:0002579)6.39938363
12positive regulation of regulated secretory pathway (GO:1903307)6.27716304
13regulation of T-helper 1 cell differentiation (GO:0045625)6.19618367
14replication fork processing (GO:0031297)5.58494658
15regulation of antigen processing and presentation (GO:0002577)5.32073601
16DNA replication-dependent nucleosome organization (GO:0034723)5.31703383
17DNA replication-dependent nucleosome assembly (GO:0006335)5.31703383
18regulation of activated T cell proliferation (GO:0046006)5.30468520
19antigen processing and presentation of endogenous antigen (GO:0019883)5.29672271
20myeloid leukocyte mediated immunity (GO:0002444)5.12290062
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.12069676
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.02481931
23positive regulation of granulocyte chemotaxis (GO:0071624)4.98901348
24defense response to fungus (GO:0050832)4.87976729
25endosome to pigment granule transport (GO:0043485)4.80152064
26endosome to melanosome transport (GO:0035646)4.80152064
27respiratory burst (GO:0045730)4.78376679
28peptide catabolic process (GO:0043171)4.77012964
29disruption of cells of other organism (GO:0044364)4.76888500
30killing of cells of other organism (GO:0031640)4.76888500
31interleukin-6-mediated signaling pathway (GO:0070102)4.73708417
32detection of bacterium (GO:0016045)4.72020829
33negative regulation of growth of symbiont in host (GO:0044130)4.70852205
34negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.70852205
35modulation of growth of symbiont involved in interaction with host (GO:0044144)4.70852205
36regulation of growth of symbiont in host (GO:0044126)4.70852205
37positive regulation of T-helper 1 type immune response (GO:0002827)4.70236659
38positive regulation of Cdc42 GTPase activity (GO:0043089)4.66567404
39response to fungus (GO:0009620)4.65503469
40peroxisome fission (GO:0016559)4.65149053
41centriole replication (GO:0007099)4.64468234
42positive regulation of natural killer cell differentiation (GO:0032825)4.59360996
43mRNA transcription from RNA polymerase II promoter (GO:0042789)4.56721189
44positive regulation of T-helper cell differentiation (GO:0045624)4.56658681
45detection of other organism (GO:0098543)4.53002529
46regulation of double-strand break repair via homologous recombination (GO:0010569)4.52568496
47regulation of MHC class II biosynthetic process (GO:0045346)4.48840111
48sequestering of actin monomers (GO:0042989)4.48697916
49centrosome duplication (GO:0051298)4.46584332
50positive regulation of neutrophil migration (GO:1902624)4.38359573
51positive regulation of neutrophil chemotaxis (GO:0090023)4.38359573
52superoxide anion generation (GO:0042554)4.35496910
53dendritic cell chemotaxis (GO:0002407)4.33191903
54leukotriene metabolic process (GO:0006691)4.32668989
55reactive oxygen species biosynthetic process (GO:1903409)4.24785418
56leukotriene biosynthetic process (GO:0019370)4.23553745
57positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.23319472
58neutrophil activation (GO:0042119)4.20961838
59response to peptidoglycan (GO:0032494)4.19059239
60leukocyte aggregation (GO:0070486)4.18820264
61negative regulation of mast cell activation (GO:0033004)4.18574017
62regulation of T cell mediated immunity (GO:0002709)4.16262828
63urate metabolic process (GO:0046415)4.14306961
64regulation of regulated secretory pathway (GO:1903305)4.13125673
65dendritic cell differentiation (GO:0097028)4.12870368
66neutrophil activation involved in immune response (GO:0002283)4.11010109
67positive regulation of gastrulation (GO:2000543)4.10425479
68leukocyte mediated cytotoxicity (GO:0001909)4.06433183
69positive regulation of glycoprotein biosynthetic process (GO:0010560)4.03860098
70regulation of isotype switching to IgG isotypes (GO:0048302)4.01577055
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99843297
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99843297
73translesion synthesis (GO:0019985)3.99612083
74mRNA transcription (GO:0009299)3.97125287
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.87964553
76granulocyte activation (GO:0036230)3.87788616
77positive regulation of interleukin-1 beta secretion (GO:0050718)3.84177378
78cytokine biosynthetic process (GO:0042089)3.83056642
79tyrosine phosphorylation of STAT protein (GO:0007260)3.81415681
80cytokine secretion (GO:0050663)3.79747621
81resolution of meiotic recombination intermediates (GO:0000712)3.74119339
82cellular response to virus (GO:0098586)3.72376372
83regulation of glucokinase activity (GO:0033131)3.72201154
84regulation of hexokinase activity (GO:1903299)3.72201154
85NIK/NF-kappaB signaling (GO:0038061)3.70941575
86cellular extravasation (GO:0045123)3.70298995
87response to nitric oxide (GO:0071731)3.70097125
88dendritic cell migration (GO:0036336)3.69612571
89cellular response to exogenous dsRNA (GO:0071360)3.68784075
90regulation of T-helper 1 type immune response (GO:0002825)3.65371212
91positive regulation of DNA recombination (GO:0045911)3.64500401
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.60568206
93positive regulation of NF-kappaB import into nucleus (GO:0042346)3.58654832
94leukocyte migration involved in inflammatory response (GO:0002523)3.58633846
95positive regulation of interleukin-1 secretion (GO:0050716)3.54408610
96centriole assembly (GO:0098534)3.53189175
97positive regulation of mast cell activation (GO:0033005)3.51074990
98regulation of interleukin-8 biosynthetic process (GO:0045414)3.50298771
99myeloid dendritic cell differentiation (GO:0043011)3.50221137
100regulation of neutrophil chemotaxis (GO:0090022)3.48177630
101regulation of neutrophil migration (GO:1902622)3.48177630
102regulation of meiosis I (GO:0060631)3.47609619
103CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.45781605
104regulation of natural killer cell differentiation (GO:0032823)3.45685861
105negative regulation of acute inflammatory response (GO:0002674)3.45264543
106regulation of T-helper cell differentiation (GO:0045622)3.45158041
107surfactant homeostasis (GO:0043129)3.45058302
108lipoxygenase pathway (GO:0019372)3.44945919
109sequestering of metal ion (GO:0051238)3.44513930
110negative regulation of phagocytosis (GO:0050765)3.39871324
111positive regulation of glycoprotein metabolic process (GO:1903020)3.39759732
112negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39704548
113negative regulation of T-helper cell differentiation (GO:0045623)3.39704548
114macrophage differentiation (GO:0030225)3.38289989
115regulation of granulocyte chemotaxis (GO:0071622)3.36512883
116regulation of interleukin-1 beta secretion (GO:0050706)3.32517356
117oxygen transport (GO:0015671)3.31806156
118myeloid dendritic cell activation (GO:0001773)3.28793022
119peptide hormone processing (GO:0016486)3.27533596
120negative regulation of bone mineralization (GO:0030502)3.26685589
121immunoglobulin mediated immune response (GO:0016064)3.24337468
122DNA strand renaturation (GO:0000733)3.21569224
123positive regulation of mast cell activation involved in immune response (GO:0033008)3.21268599
124positive regulation of mast cell degranulation (GO:0043306)3.21268599
125cell killing (GO:0001906)3.20619589
126hydrogen peroxide catabolic process (GO:0042744)3.17756362
127intra-S DNA damage checkpoint (GO:0031573)3.17294220
128leukocyte cell-cell adhesion (GO:0007159)3.16788153
129cytokine metabolic process (GO:0042107)3.16425323
130regulation of leukocyte mediated immunity (GO:0002703)3.16159858
131positive regulation of protein deacetylation (GO:0090312)3.15806262
132positive regulation of histone deacetylation (GO:0031065)3.14109183
133regulation of mast cell activation (GO:0033003)3.13604684
134hydrogen peroxide biosynthetic process (GO:0050665)3.12567533
135regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11305865
136positive regulation of interleukin-1 beta production (GO:0032731)3.10886969
137regulation of mast cell degranulation (GO:0043304)3.06474471
138leukocyte tethering or rolling (GO:0050901)3.06365362
139positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04107719
140definitive hemopoiesis (GO:0060216)3.03565576
141regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.99884662
142positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99748177
143negative regulation of interleukin-8 production (GO:0032717)2.99673222
144heart valve formation (GO:0003188)2.99008723
145regulation of interleukin-1 secretion (GO:0050704)2.98867843
146programmed necrotic cell death (GO:0097300)2.98196370
147negative regulation of interleukin-10 production (GO:0032693)2.96550184
148positive regulation of granulocyte differentiation (GO:0030854)2.96520318
149positive regulation of interleukin-1 production (GO:0032732)2.94661866
150fucose catabolic process (GO:0019317)2.92508673
151L-fucose metabolic process (GO:0042354)2.92508673
152L-fucose catabolic process (GO:0042355)2.92508673
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91940992
154cytokine production involved in immune response (GO:0002367)2.89668233
155regulation of cytokine production involved in immune response (GO:0002718)2.89439933
156detection of external biotic stimulus (GO:0098581)2.88052526
157regulation of leukocyte degranulation (GO:0043300)2.84831480
158phosphate ion homeostasis (GO:0055062)2.84721622
159trivalent inorganic anion homeostasis (GO:0072506)2.84721622
160secretory granule organization (GO:0033363)2.84699239
161regulation of activation of Janus kinase activity (GO:0010533)2.84384035
162cellular response to dsRNA (GO:0071359)2.84190271
163production of molecular mediator involved in inflammatory response (GO:0002532)2.83957115
164regulation of mast cell activation involved in immune response (GO:0033006)2.83842172
165positive regulation of isotype switching (GO:0045830)2.80283094
166negative regulation of biomineral tissue development (GO:0070168)2.77151230
167regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77080255
168DNA dealkylation (GO:0035510)2.72333453
169necrotic cell death (GO:0070265)2.71041904
170regulation of lymphocyte mediated immunity (GO:0002706)2.68232329
171CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.67604687
172regulation of chronic inflammatory response (GO:0002676)2.66891788
173regulation of proton transport (GO:0010155)2.65641182
174regulation of DNA recombination (GO:0000018)2.64881745
175negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.64186090
176negative regulation of adaptive immune response (GO:0002820)2.63195905
177positive regulation of hormone biosynthetic process (GO:0046886)2.62648434
178negative regulation of granulocyte differentiation (GO:0030853)2.61908638
179chromatin assembly (GO:0031497)2.60782659
180positive regulation of interferon-alpha production (GO:0032727)2.59891799
181positive regulation of chemokine biosynthetic process (GO:0045080)2.59569420
182genitalia morphogenesis (GO:0035112)2.57033617
183positive regulation of protein import into nucleus, translocation (GO:0033160)2.55421025
184regulation of female gonad development (GO:2000194)2.53710178
185regulation of T cell tolerance induction (GO:0002664)13.4390749
186regulation of tolerance induction (GO:0002643)11.3802170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.38854071
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.07460005
3E2F7_22180533_ChIP-Seq_HELA_Human4.32188977
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.32130099
5* MYB_21317192_ChIP-Seq_ERMYB_Mouse4.27738477
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20470113
7EGR1_19374776_ChIP-ChIP_THP-1_Human4.05120389
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.86998620
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57040075
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.25957770
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13834733
12TP63_19390658_ChIP-ChIP_HaCaT_Human3.12283258
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.09424017
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95633479
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92885979
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.91939656
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91798765
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.91708368
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.79838952
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78848452
21GATA1_22025678_ChIP-Seq_K562_Human2.77315486
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65739838
23SCL_19346495_ChIP-Seq_HPC-7_Human2.63199693
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54370890
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47737096
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46528281
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45565977
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35693505
29VDR_21846776_ChIP-Seq_THP-1_Human2.31577371
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18046020
31IRF1_19129219_ChIP-ChIP_H3396_Human2.15390422
32VDR_24763502_ChIP-Seq_THP-1_Human2.13976863
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.6063215
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98278875
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.97405974
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94705980
37* MYB_26560356_Chip-Seq_TH2_Human1.94666578
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93622815
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92870874
40SPI1_23547873_ChIP-Seq_NB4_Human1.90570260
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87198680
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.74557751
43PU_27001747_Chip-Seq_BMDM_Mouse1.73465783
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69407588
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66749937
46* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60870222
47SPI1_23127762_ChIP-Seq_K562_Human1.60037311
48MAF_26560356_Chip-Seq_TH1_Human1.54353698
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54063324
50VDR_24787735_ChIP-Seq_THP-1_Human1.53377363
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.48947791
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46789832
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.45353801
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43573920
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.40499525
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37105650
57* MYB_26560356_Chip-Seq_TH1_Human1.35440400
58EGR1_19032775_ChIP-ChIP_M12_Human1.34144963
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32824715
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31006039
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30852616
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29881549
63UTX_26944678_Chip-Seq_JUKART_Human1.28555019
64RUNX_20019798_ChIP-Seq_JUKART_Human1.28280001
65* GATA2_19941826_ChIP-Seq_K562_Human1.27416896
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25871369
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24762855
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23762794
69GATA1_19941826_ChIP-Seq_K562_Human1.23397250
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21010662
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19949448
72GATA3_26560356_Chip-Seq_TH2_Human1.19856425
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19477840
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18739423
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16761002
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16414087
77TCF7_22412390_ChIP-Seq_EML_Mouse1.15682067
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15655073
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15268587
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14104092
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13776409
82GATA3_27048872_Chip-Seq_THYMUS_Human1.11156094
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10991020
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08925998
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08659265
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04899318
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.04430488
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04395196
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04073076
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02505393
91TAF2_19829295_ChIP-Seq_ESCs_Human1.01185252
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99931983
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99628733
94* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98595577
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97672270
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.96461376
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96152744
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.95895064
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94609622
100TP53_22573176_ChIP-Seq_HFKS_Human0.93383997
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92937144
102SOX2_20726797_ChIP-Seq_SW620_Human0.92495648
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91566074
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.91289879
105BCL6_27268052_Chip-Seq_Bcells_Human0.91050904
106LXR_22292898_ChIP-Seq_THP-1_Human0.89344223
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88720635
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88057331
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87932698
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87759555
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87432882
112NANOG_20526341_ChIP-Seq_ESCs_Human0.87007492
113* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85714334
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85600955
115MYC_22102868_ChIP-Seq_BL_Human0.84552477
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84388914
117MAF_26560356_Chip-Seq_TH2_Human0.84165149
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82917578
119OCT4_20526341_ChIP-Seq_ESCs_Human0.82610400
120CLOCK_20551151_ChIP-Seq_293T_Human0.82176832
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.81700057
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80338476
123GATA4_25053715_ChIP-Seq_YYC3_Human0.80227394
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.80045407
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79766240
126STAT1_17558387_ChIP-Seq_HELA_Human0.79252275
127FOXP3_21729870_ChIP-Seq_TREG_Human0.78138723
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77066315
129SPI1_20517297_ChIP-Seq_HL60_Human0.76416214
130ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76402572
131P300_27268052_Chip-Seq_Bcells_Human0.75399820
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74870293
133* SMRT_27268052_Chip-Seq_Bcells_Human0.74860077
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.74005338
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73935172
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73865827
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73834142
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72858919
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72364582
140EZH2_22144423_ChIP-Seq_EOC_Human0.70280638
141DROSHA_22980978_ChIP-Seq_HELA_Human0.70245532
142* NCOR1_26117541_ChIP-Seq_K562_Human0.66872345
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62980075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.72825579
2MP0000685_abnormal_immune_system4.36908759
3MP0005171_absent_coat_pigmentation4.00865841
4MP0005075_abnormal_melanosome_morpholog3.82002201
5MP0008961_abnormal_basal_metabolism3.59366384
6MP0003303_peritoneal_inflammation3.58140776
7MP0001835_abnormal_antigen_presentation3.37816686
8MP0002876_abnormal_thyroid_physiology3.23642136
9MP0003436_decreased_susceptibility_to3.20473992
10MP0000372_irregular_coat_pigmentation3.19876543
11MP0001873_stomach_inflammation3.06954512
12MP0009785_altered_susceptibility_to2.98192373
13MP0008058_abnormal_DNA_repair2.88855645
14MP0003724_increased_susceptibility_to2.77056015
15MP0005503_abnormal_tendon_morphology2.73788159
16MP0009840_abnormal_foam_cell2.64056811
17MP0005025_abnormal_response_to2.51557202
18MP0002419_abnormal_innate_immunity2.47095588
19MP0005083_abnormal_biliary_tract2.44808499
20MP0002148_abnormal_hypersensitivity_rea2.44535320
21MP0004782_abnormal_surfactant_physiolog2.44160691
22MP0003183_abnormal_peptide_metabolism2.39007913
23MP0005671_abnormal_response_to2.30504078
24MP0001348_abnormal_lacrimal_gland2.25480378
25MP0001853_heart_inflammation2.23711488
26MP0006082_CNS_inflammation2.21214635
27MP0003300_gastrointestinal_ulcer2.21170381
28MP0005310_abnormal_salivary_gland2.20490740
29MP0003283_abnormal_digestive_organ2.16790311
30MP0005000_abnormal_immune_tolerance2.16622016
31MP0002138_abnormal_hepatobiliary_system2.14603546
32MP0005387_immune_system_phenotype2.14540005
33MP0001790_abnormal_immune_system2.14540005
34MP0004510_myositis2.13746998
35MP0002405_respiratory_system_inflammati2.04258565
36MP0009278_abnormal_bone_marrow1.96238657
37MP0010094_abnormal_chromosome_stability1.93085182
38MP0005464_abnormal_platelet_physiology1.91299254
39MP0001533_abnormal_skeleton_physiology1.89773838
40MP0003718_maternal_effect1.86784082
41MP0003693_abnormal_embryo_hatching1.84681294
42MP0009764_decreased_sensitivity_to1.81042976
43MP0005645_abnormal_hypothalamus_physiol1.80021547
44MP0000733_abnormal_muscle_development1.79556709
45MP0001800_abnormal_humoral_immune1.78724887
46MP0000343_altered_response_to1.77381114
47MP0001845_abnormal_inflammatory_respons1.72516062
48MP0008995_early_reproductive_senescence1.70984839
49MP0004147_increased_porphyrin_level1.70433886
50MP0002452_abnormal_antigen_presenting1.68872443
51MP0001819_abnormal_immune_cell1.65718395
52MP0010155_abnormal_intestine_physiology1.64650578
53MP0002420_abnormal_adaptive_immunity1.64292319
54MP0001851_eye_inflammation1.61674545
55MP0001346_abnormal_lacrimal_gland1.60648608
56MP0002723_abnormal_immune_serum1.60385768
57MP0003787_abnormal_imprinting1.60083900
58MP0008789_abnormal_olfactory_epithelium1.59730740
59MP0003075_altered_response_to1.59114985
60MP0006276_abnormal_autonomic_nervous1.57568654
61MP0005397_hematopoietic_system_phenotyp1.54750637
62MP0001545_abnormal_hematopoietic_system1.54750637
63MP0002127_abnormal_cardiovascular_syste1.52612170
64MP0005174_abnormal_tail_pigmentation1.51517451
65MP0002396_abnormal_hematopoietic_system1.50281854
66MP0005647_abnormal_sex_gland1.48465590
67MP0008877_abnormal_DNA_methylation1.47497219
68MP0009333_abnormal_splenocyte_physiolog1.45675157
69MP0002877_abnormal_melanocyte_morpholog1.43073269
70MP0005167_abnormal_blood-brain_barrier1.41570971
71MP0005058_abnormal_lysosome_morphology1.39425653
72MP0003763_abnormal_thymus_physiology1.37982506
73MP0006054_spinal_hemorrhage1.34086368
74MP0000858_altered_metastatic_potential1.32036081
75MP0000371_diluted_coat_color1.28840859
76* MP0000716_abnormal_immune_system1.27187069
77MP0008004_abnormal_stomach_pH1.27033816
78MP0008469_abnormal_protein_level1.26941358
79MP0002277_abnormal_respiratory_mucosa1.25869534
80MP0001764_abnormal_homeostasis1.23954979
81MP0004947_skin_inflammation1.22073356
82MP0005394_taste/olfaction_phenotype1.22001641
83MP0005499_abnormal_olfactory_system1.22001641
84MP0003448_altered_tumor_morphology1.17970306
85MP0002166_altered_tumor_susceptibility1.17744642
86MP0001663_abnormal_digestive_system1.17169743
87MP0002398_abnormal_bone_marrow1.16140484
88MP0003638_abnormal_response/metabolism_1.14241751
89MP0001958_emphysema1.13533442
90MP0003136_yellow_coat_color1.09403911
91MP0005164_abnormal_response_to1.06544468
92MP0008057_abnormal_DNA_replication1.05349884
93MP0003453_abnormal_keratinocyte_physiol1.04604377
94MP0004185_abnormal_adipocyte_glucose1.03759010
95MP0000465_gastrointestinal_hemorrhage1.03414241
96* MP0002429_abnormal_blood_cell1.01486015
97MP0003950_abnormal_plasma_membrane0.98900918
98MP0002006_tumorigenesis0.97941196
99MP0003828_pulmonary_edema0.97867580
100MP0003172_abnormal_lysosome_physiology0.91738426
101MP0004808_abnormal_hematopoietic_stem0.90545488
102* MP0009115_abnormal_fat_cell0.89822308
103MP0002210_abnormal_sex_determination0.89607804
104MP0002722_abnormal_immune_system0.89512277
105MP0001929_abnormal_gametogenesis0.88243403
106MP0003656_abnormal_erythrocyte_physiolo0.87168605
107MP0003121_genomic_imprinting0.87156453
108MP0003699_abnormal_female_reproductive0.87139490
109MP0005332_abnormal_amino_acid0.86340491
110MP0009765_abnormal_xenobiotic_induced0.82916131
111MP0003879_abnormal_hair_cell0.82483981
112MP0003111_abnormal_nucleus_morphology0.80559644
113MP0003191_abnormal_cellular_cholesterol0.80245060
114MP0005319_abnormal_enzyme/_coenzyme0.79064097
115MP0003195_calcinosis0.78904317
116MP0005584_abnormal_enzyme/coenzyme_acti0.77747398
117MP0000689_abnormal_spleen_morphology0.77332385
118MP0001324_abnormal_eye_pigmentation0.77331246
119MP0003279_aneurysm0.76878984
120MP0004883_abnormal_blood_vessel0.76696900
121MP0005197_abnormal_uvea_morphology0.76103627
122MP0003698_abnormal_male_reproductive0.75622620
123MP0005023_abnormal_wound_healing0.75007746
124MP0005390_skeleton_phenotype0.74911616
125MP0005166_decreased_susceptibility_to0.74814638
126MP0002118_abnormal_lipid_homeostasis0.74501859
127MP0000470_abnormal_stomach_morphology0.74357682
128MP0002928_abnormal_bile_duct0.74011397
129MP0002933_joint_inflammation0.72232969
130MP0005381_digestive/alimentary_phenotyp0.71371546
131MP0001730_embryonic_growth_arrest0.70553919
132MP0003566_abnormal_cell_adhesion0.69983699
133MP0003045_fibrosis0.69142833
134MP0009763_increased_sensitivity_to0.68055808
135MP0002133_abnormal_respiratory_system0.66859087
136MP0005388_respiratory_system_phenotype0.66859087
137MP0005076_abnormal_cell_differentiation0.66100390
138MP0000003_abnormal_adipose_tissue0.65337433
139MP0000653_abnormal_sex_gland0.64996094
140MP0003866_abnormal_defecation0.64297018
141MP0002132_abnormal_respiratory_system0.64257048
142MP0009643_abnormal_urine_homeostasis0.63676074
143MP0001119_abnormal_female_reproductive0.62335673
144MP0001881_abnormal_mammary_gland0.62088367
145MP0003795_abnormal_bone_structure0.61843963
146MP0000703_abnormal_thymus_morphology0.60157561
147MP0002998_abnormal_bone_remodeling0.59442699
148MP0000490_abnormal_crypts_of0.59144448
149MP0001145_abnormal_male_reproductive0.58933534
150MP0008872_abnormal_physiological_respon0.56934877

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.98404731
2Failure to thrive in infancy (HP:0001531)7.46902227
3Eczematoid dermatitis (HP:0000976)7.18719672
4Recurrent abscess formation (HP:0002722)6.03448663
5Recurrent gram-negative bacterial infections (HP:0005420)5.66980446
6Recurrent bacterial skin infections (HP:0005406)5.64533075
7Keratoconjunctivitis (HP:0001096)5.30708775
8Chronic mucocutaneous candidiasis (HP:0002728)5.29675361
9Recurrent cutaneous fungal infections (HP:0011370)5.29675361
10Interstitial pulmonary disease (HP:0006530)4.94208945
11Recurrent fungal infections (HP:0002841)4.83534386
12Chronic obstructive pulmonary disease (HP:0006510)4.74182309
13Obstructive lung disease (HP:0006536)4.74182309
14Recurrent skin infections (HP:0001581)4.65334814
15Myositis (HP:0100614)4.55742480
16Abnormality of macrophages (HP:0004311)4.51856532
17Orthostatic hypotension (HP:0001278)4.51745529
18Increased IgE level (HP:0003212)4.41998247
19Premature graying of hair (HP:0002216)4.39220233
20Orchitis (HP:0100796)4.28406044
21Papilledema (HP:0001085)4.08690097
22Episodic fever (HP:0001954)4.05932873
23Rough bone trabeculation (HP:0100670)4.05173342
24Gingivitis (HP:0000230)4.01978649
25Mediastinal lymphadenopathy (HP:0100721)3.87075490
26Retrobulbar optic neuritis (HP:0100654)3.75898142
27Optic neuritis (HP:0100653)3.75898142
28Urticaria (HP:0001025)3.64356798
29Recurrent corneal erosions (HP:0000495)3.57076554
30Periodontitis (HP:0000704)3.56167616
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50947394
32Rhinitis (HP:0012384)3.47912261
33Alveolar cell carcinoma (HP:0006519)3.43477175
34Pustule (HP:0200039)3.42677962
35Panhypogammaglobulinemia (HP:0003139)3.35525327
36Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29640913
37Stomatitis (HP:0010280)3.29445086
38Meningitis (HP:0001287)3.28784911
39Keratoconjunctivitis sicca (HP:0001097)3.18313475
40Neoplasm of the tracheobronchial system (HP:0100552)3.13429411
41Intrahepatic cholestasis (HP:0001406)3.12821059
42Impaired proprioception (HP:0010831)3.12242506
43Elevated erythrocyte sedimentation rate (HP:0003565)3.06260228
44Autoimmune hemolytic anemia (HP:0001890)3.05895914
45Thrombocytosis (HP:0001894)3.03880647
46Chronic otitis media (HP:0000389)3.02394618
47Abnormal trabecular bone morphology (HP:0100671)2.98540879
48Vasculitis (HP:0002633)2.97532253
49Hypophosphatemic rickets (HP:0004912)2.96952454
50Cellular immunodeficiency (HP:0005374)2.96517311
51Gangrene (HP:0100758)2.93147853
52Cellulitis (HP:0100658)2.92274145
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.91228618
54Hemoptysis (HP:0002105)2.90674331
55Neurodegeneration (HP:0002180)2.87795067
56Spastic diplegia (HP:0001264)2.86405352
57Bone marrow hypocellularity (HP:0005528)2.85217073
58Nasal polyposis (HP:0100582)2.83154960
59Arthropathy (HP:0003040)2.79573133
60Abnormality of the nasal mucosa (HP:0000433)2.76553886
61Pulmonary infiltrates (HP:0002113)2.75638954
62Abnormality of the prostate (HP:0008775)2.75007065
63Renal Fanconi syndrome (HP:0001994)2.71389828
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.70511046
65Petechiae (HP:0000967)2.69357973
66Keratitis (HP:0000491)2.68994520
67Hypergammaglobulinemia (HP:0010702)2.68770932
68Albinism (HP:0001022)2.68728542
69Prolonged bleeding time (HP:0003010)2.65332098
70Agammaglobulinemia (HP:0004432)2.62774769
71Arterial thrombosis (HP:0004420)2.60775370
72Acute hepatic failure (HP:0006554)2.59979990
73Abnormality of T cells (HP:0002843)2.58816409
74Onycholysis (HP:0001806)2.57837402
75Recurrent pneumonia (HP:0006532)2.56609817
76Chest pain (HP:0100749)2.56305260
77Generalized hyperpigmentation (HP:0007440)2.56068862
78Duplicated collecting system (HP:0000081)2.52180251
79Infertility (HP:0000789)2.50486799
80Abnormality of the renal collecting system (HP:0004742)2.49641648
81Plantar hyperkeratosis (HP:0007556)2.48277893
82Aseptic necrosis (HP:0010885)2.46418863
83Gingival bleeding (HP:0000225)2.44784442
84Eosinophilia (HP:0001880)2.42543817
85Aplastic anemia (HP:0001915)2.41938727
86Abnormality of pyrimidine metabolism (HP:0004353)2.41407632
87Hepatitis (HP:0012115)2.40239638
88Skin ulcer (HP:0200042)2.33484774
89Inflammation of the large intestine (HP:0002037)2.32892594
90Abnormality of the gastric mucosa (HP:0004295)2.32217419
91Pulmonary embolism (HP:0002204)2.32159963
92Asplenia (HP:0001746)2.31672268
93Hypokinesia (HP:0002375)2.31277715
94Impulsivity (HP:0100710)2.30412076
95Global brain atrophy (HP:0002283)2.30256933
96Vacuolated lymphocytes (HP:0001922)2.29931056
97Palmoplantar hyperkeratosis (HP:0000972)2.28641774
98Granulocytopenia (HP:0001913)2.28172140
99Polyneuropathy (HP:0001271)2.25626756
100Leukocytosis (HP:0001974)2.25317895
101Type I diabetes mellitus (HP:0100651)2.23842911
102Cheilitis (HP:0100825)2.23129184
103Spontaneous hematomas (HP:0007420)2.22332351
104Encephalitis (HP:0002383)2.22117773
105Recurrent lower respiratory tract infections (HP:0002783)2.20180736
106Cutaneous melanoma (HP:0012056)2.19311390
107IgG deficiency (HP:0004315)2.17357654
108Osteomyelitis (HP:0002754)2.17079866
109Sepsis (HP:0100806)2.16683070
110Prolonged neonatal jaundice (HP:0006579)2.15638417
111Abdominal situs inversus (HP:0003363)2.15628587
112Abnormality of abdominal situs (HP:0011620)2.15628587
113Poikiloderma (HP:0001029)2.15130517
114Gastrointestinal inflammation (HP:0004386)2.14184752
115Epistaxis (HP:0000421)2.12736320
116Dysautonomia (HP:0002459)2.12532520
117Hyponatremia (HP:0002902)2.12100693
118Hematochezia (HP:0002573)2.12065806
119Thrombophlebitis (HP:0004418)2.11543764
120Lymphoma (HP:0002665)2.10094428
121Palmar hyperkeratosis (HP:0010765)2.06829627
122Respiratory distress (HP:0002098)2.05264660
123Alacrima (HP:0000522)2.04255304
124Impaired vibration sensation in the lower limbs (HP:0002166)2.03460359
125Hydroxyprolinuria (HP:0003080)2.01518080
126Abnormality of proline metabolism (HP:0010907)2.01518080
127Chronic bronchitis (HP:0004469)1.98750842
128Ureteral stenosis (HP:0000071)1.96479195
129Hyperactive renin-angiotensin system (HP:0000841)1.96158846
130Chronic sinusitis (HP:0011109)1.95202084
131Abnormality of the pleura (HP:0002103)1.95065754
132Impaired platelet aggregation (HP:0003540)1.94872821
133Abnormal platelet function (HP:0011869)1.94872821
134Polydipsia (HP:0001959)1.94296511
135Abnormal drinking behavior (HP:0030082)1.94296511
136Restrictive lung disease (HP:0002091)1.92073614
137Tongue fasciculations (HP:0001308)1.91650003
138Abnormality of transition element cation homeostasis (HP:0011030)1.90855744
139Hemorrhage of the eye (HP:0011885)1.90764769
140Abnormality of T cell physiology (HP:0011840)1.89920144
141Recurrent viral infections (HP:0004429)1.88737722
142Abnormal autonomic nervous system physiology (HP:0012332)1.86802404
143Gastrointestinal infarctions (HP:0005244)1.85906744
144Teleangiectasia of the skin (HP:0100585)1.83456432
145Recurrent sinusitis (HP:0011108)1.83049057
146Tubulointerstitial fibrosis (HP:0005576)1.82108020
147Abnormal rod and cone electroretinograms (HP:0008323)1.81744637
148Ventricular fibrillation (HP:0001663)1.81419777
149Colitis (HP:0002583)1.81230447
150Abnormality of calcium-phosphate metabolism (HP:0100530)1.80736061
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79054635
152Annular pancreas (HP:0001734)1.79024352
153Viral hepatitis (HP:0006562)1.78583848
154Abnormality of the basal ganglia (HP:0002134)1.77534979
155Death in infancy (HP:0001522)1.77187718
156Abnormality of eosinophils (HP:0001879)1.76731911
157Generalized aminoaciduria (HP:0002909)1.76174405
158Ureteral obstruction (HP:0006000)1.75295813
159Tetraparesis (HP:0002273)1.75282503
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75020259
161Abnormality of the pericardium (HP:0001697)1.74610665
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.74314559
163Recurrent otitis media (HP:0000403)1.74133277
164Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73215775
165Bronchitis (HP:0012387)1.72949442
166Neutropenia (HP:0001875)1.72041465
167Poikilocytosis (HP:0004447)1.71384109
168Congenital ichthyosiform erythroderma (HP:0007431)1.71208612
169Systemic lupus erythematosus (HP:0002725)1.68219458
170Autoimmune thrombocytopenia (HP:0001973)1.67571027
171Short humerus (HP:0005792)1.65841175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.50003855
2MAP3K144.48889409
3EPHB13.58934694
4TNIK3.44550603
5TXK3.39373482
6ERN12.66026387
7TAOK12.60148607
8DYRK32.56110007
9TEC2.50806874
10BTK2.41807107
11IRAK32.39101990
12PRPF4B2.36727513
13BLK2.27019453
14STK102.17708242
15ERBB32.16028073
16FER2.15845321
17TRIM2812.3828942
18EPHA31.98451185
19TYK21.94777150
20IKBKE1.86868710
21TAOK31.82007406
22MAP3K121.81416809
23TBK11.75033323
24PDK21.73060221
25ZAP701.71335597
26PRKD21.67743186
27ITK1.66705452
28PTK61.63463145
29MAP2K31.62350569
30LRRK21.61154365
31TRPM71.53383658
32CSK1.49433641
33FGFR41.48471638
34MST41.44620449
35CLK11.44425990
36MAP4K11.41852664
37BCKDK1.38476760
38JAK31.35175276
39HCK1.33778160
40FES1.33421376
41MARK21.33080894
42SYK1.31884393
43JAK21.30828673
44PAK41.30256821
45TAOK21.28372913
46RIPK41.26433528
47SIK31.25913305
48JAK11.25624623
49IKBKB1.22260408
50DYRK1B1.20771209
51STK241.12416946
52PNCK1.10175054
53CHUK1.10080460
54NTRK11.08148514
55CSF1R1.04346011
56GRK61.03789954
57GRK71.03083147
58KIT1.02360572
59TESK10.97639211
60EIF2AK20.96978216
61MOS0.96614018
62FGFR30.95845891
63MAP3K30.93237208
64DAPK20.92996259
65MATK0.89061951
66HIPK20.85114040
67FRK0.81873402
68TGFBR20.81381458
69MARK30.79756058
70PRKG20.78769065
71NLK0.77340249
72CAMK1G0.77028542
73MAP3K60.73304485
74GRK10.72259980
75WNK10.72257903
76PIM20.70185615
77TRIB30.69229828
78MYLK0.67890510
79SIK20.67391742
80CDK60.67180921
81BMPR20.66746657
82LYN0.64285219
83PRKCD0.64058778
84PTK20.63938869
85SCYL20.61873348
86ATR0.61268326
87PRKCQ0.60933959
88NEK90.60850046
89EEF2K0.60643630
90IRAK10.60428469
91EPHA20.59503250
92STK380.58353096
93MAPKAPK20.57942301
94LCK0.53905395
95MAPK40.52209498
96ALK0.52128176
97PDK10.51503150
98GSK3A0.51359525
99MAPK150.51163341
100ILK0.50090797
101INSR0.49464463
102KDR0.49350255
103TNK20.49251884
104EGFR0.49092420
105PRKAA20.48668353
106PIM10.48636138
107VRK10.48605947
108NME10.48265534
109PKN10.46082008
110FGR0.44249091
111RPS6KC10.44022239
112RPS6KL10.44022239
113RPS6KA60.42594033
114RPS6KA40.41594723
115MAPK100.41516102
116PIK3CG0.41095803
117MAP2K20.41027745
118PKN20.40726258
119TIE10.38443185
120RPS6KA20.37514305
121EIF2AK30.37345618
122RIPK10.36276777
123CDC70.36240212
124MAPK30.35351588
125STK160.35246625
126MAPK110.34443764
127RAF10.32697430
128MAP3K10.31951780
129CHEK10.31303875
130PRKCH0.31149253
131TGFBR10.29787133
132PAK10.29584330
133MKNK10.29424744
134MAP2K60.29200236
135MAP3K80.28829454
136PRKCI0.28383699
137ABL10.27688817
138NEK20.25314512
139AKT10.25311784
140EPHA40.24283438
141BMPR1B0.23666699
142CAMKK10.23417034
143PRKCZ0.22607474
144CDK70.21850764
145CDK20.20437179
146MAPK10.19391716
147ERBB20.18925139
148PRKACA0.17437746
149CAMK1D0.17185423
150ADRBK20.16734168
151CSNK2A10.16728858
152WNK40.16530215

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.27678029
2Leishmaniasis_Homo sapiens_hsa051404.03438454
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.71580777
4Staphylococcus aureus infection_Homo sapiens_hsa051502.93450340
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.75041081
6Osteoclast differentiation_Homo sapiens_hsa043802.17372093
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14810188
8Primary immunodeficiency_Homo sapiens_hsa053402.13049800
9Pertussis_Homo sapiens_hsa051332.04879562
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.04449280
11Antigen processing and presentation_Homo sapiens_hsa046121.96272972
12Tuberculosis_Homo sapiens_hsa051521.85602417
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.84812548
14Allograft rejection_Homo sapiens_hsa053301.82951233
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82061702
16Legionellosis_Homo sapiens_hsa051341.79522907
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.73568357
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69968016
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.69340452
20Toxoplasmosis_Homo sapiens_hsa051451.69153825
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67851344
22Autoimmune thyroid disease_Homo sapiens_hsa053201.65957186
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59427897
24Chemokine signaling pathway_Homo sapiens_hsa040621.56293106
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55732618
26Malaria_Homo sapiens_hsa051441.53226430
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48248513
28Phagosome_Homo sapiens_hsa041451.44603596
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44382869
30Hematopoietic cell lineage_Homo sapiens_hsa046401.43947873
31Fanconi anemia pathway_Homo sapiens_hsa034601.40755603
32TNF signaling pathway_Homo sapiens_hsa046681.37846535
33Other glycan degradation_Homo sapiens_hsa005111.37136312
34Pancreatic secretion_Homo sapiens_hsa049721.36932728
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36280593
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.34196649
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31568399
38Measles_Homo sapiens_hsa051621.29644862
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29371560
40Nitrogen metabolism_Homo sapiens_hsa009101.28448533
41African trypanosomiasis_Homo sapiens_hsa051431.26473180
42* Histidine metabolism_Homo sapiens_hsa003401.21165992
43Oocyte meiosis_Homo sapiens_hsa041141.18700088
44B cell receptor signaling pathway_Homo sapiens_hsa046621.16221391
45Protein digestion and absorption_Homo sapiens_hsa049741.12560791
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11558700
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09106241
48Pentose phosphate pathway_Homo sapiens_hsa000301.08343253
49Rheumatoid arthritis_Homo sapiens_hsa053231.07288502
50mRNA surveillance pathway_Homo sapiens_hsa030151.07117851
51Influenza A_Homo sapiens_hsa051641.06887944
52Homologous recombination_Homo sapiens_hsa034401.06755094
53Arachidonic acid metabolism_Homo sapiens_hsa005901.05781893
54Apoptosis_Homo sapiens_hsa042101.04608664
55ABC transporters_Homo sapiens_hsa020101.03991435
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00086308
57Lysosome_Homo sapiens_hsa041420.99720222
58Herpes simplex infection_Homo sapiens_hsa051680.98944667
59Nucleotide excision repair_Homo sapiens_hsa034200.98900693
60Amoebiasis_Homo sapiens_hsa051460.98708103
61Salmonella infection_Homo sapiens_hsa051320.98608576
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.97521754
63Acute myeloid leukemia_Homo sapiens_hsa052210.89970941
64Shigellosis_Homo sapiens_hsa051310.88065174
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86332415
66Basal transcription factors_Homo sapiens_hsa030220.86272782
67Renin-angiotensin system_Homo sapiens_hsa046140.84948524
68Caffeine metabolism_Homo sapiens_hsa002320.84232403
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83262188
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82160121
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81908781
72Ovarian steroidogenesis_Homo sapiens_hsa049130.79753841
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79673381
74Small cell lung cancer_Homo sapiens_hsa052220.76518747
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76188198
76Hepatitis C_Homo sapiens_hsa051600.71226973
77Graft-versus-host disease_Homo sapiens_hsa053320.69839043
78Hepatitis B_Homo sapiens_hsa051610.68539940
79Glutathione metabolism_Homo sapiens_hsa004800.68452431
80Starch and sucrose metabolism_Homo sapiens_hsa005000.67568748
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67516623
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66283375
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66113890
84Pancreatic cancer_Homo sapiens_hsa052120.65965707
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65450107
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.65115976
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62923578
88Phenylalanine metabolism_Homo sapiens_hsa003600.58953707
89Mismatch repair_Homo sapiens_hsa034300.57553901
90Linoleic acid metabolism_Homo sapiens_hsa005910.57021449
91Vitamin digestion and absorption_Homo sapiens_hsa049770.56749747
92Insulin resistance_Homo sapiens_hsa049310.56308382
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56082665
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53690928
95Sphingolipid metabolism_Homo sapiens_hsa006000.53180194
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51339746
97Galactose metabolism_Homo sapiens_hsa000520.51284682
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50898264
99Chemical carcinogenesis_Homo sapiens_hsa052040.50000022
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49138186
101Platelet activation_Homo sapiens_hsa046110.48471904
102Chronic myeloid leukemia_Homo sapiens_hsa052200.48192215
103T cell receptor signaling pathway_Homo sapiens_hsa046600.45828526
104Olfactory transduction_Homo sapiens_hsa047400.45022787
105VEGF signaling pathway_Homo sapiens_hsa043700.43594769
106Complement and coagulation cascades_Homo sapiens_hsa046100.41729877
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41045077
108Non-small cell lung cancer_Homo sapiens_hsa052230.39436407
109beta-Alanine metabolism_Homo sapiens_hsa004100.39070345
110Cell cycle_Homo sapiens_hsa041100.38152398
111Ether lipid metabolism_Homo sapiens_hsa005650.37306946
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.37115720
113Renal cell carcinoma_Homo sapiens_hsa052110.35944772
114Phototransduction_Homo sapiens_hsa047440.34920684
115Arginine biosynthesis_Homo sapiens_hsa002200.34442068
116Spliceosome_Homo sapiens_hsa030400.33149801
117Viral myocarditis_Homo sapiens_hsa054160.31353863
118Long-term depression_Homo sapiens_hsa047300.30938026
119Inositol phosphate metabolism_Homo sapiens_hsa005620.30612321
120Peroxisome_Homo sapiens_hsa041460.30347088
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30151866
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29194154
123TGF-beta signaling pathway_Homo sapiens_hsa043500.27976802
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.27638913
125Prolactin signaling pathway_Homo sapiens_hsa049170.27236564
126p53 signaling pathway_Homo sapiens_hsa041150.27156183
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26978541
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.26179212
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25581781
130Thyroid hormone synthesis_Homo sapiens_hsa049180.24906104
131Viral carcinogenesis_Homo sapiens_hsa052030.24629469
132DNA replication_Homo sapiens_hsa030300.24214478
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23894398
134HIF-1 signaling pathway_Homo sapiens_hsa040660.23021027
135N-Glycan biosynthesis_Homo sapiens_hsa005100.22966934
136Choline metabolism in cancer_Homo sapiens_hsa052310.22124628
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22088161
138Retinol metabolism_Homo sapiens_hsa008300.21219851
139Dopaminergic synapse_Homo sapiens_hsa047280.20575124
140AMPK signaling pathway_Homo sapiens_hsa041520.19914817
141Fat digestion and absorption_Homo sapiens_hsa049750.19812296
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19388182
143Base excision repair_Homo sapiens_hsa034100.19075669
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18879434
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17477654
146RNA degradation_Homo sapiens_hsa030180.16544848

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