HDDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.53912627
2mitotic metaphase plate congression (GO:0007080)6.75123329
3regulation of female gonad development (GO:2000194)6.64045887
4female gamete generation (GO:0007292)5.94676261
5regulation of meiosis (GO:0040020)5.80347588
6mitotic chromosome condensation (GO:0007076)5.75788106
7negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.74538497
8regulation of meiosis I (GO:0060631)5.43745084
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.42096675
10metaphase plate congression (GO:0051310)5.35626654
11regulation of exit from mitosis (GO:0007096)5.17714348
12monoubiquitinated protein deubiquitination (GO:0035520)5.17647619
13oocyte maturation (GO:0001556)5.15752470
14histone H2A monoubiquitination (GO:0035518)4.99899401
15negative regulation of meiosis (GO:0045835)4.96491328
16meiotic chromosome segregation (GO:0045132)4.95642590
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94054051
18protein K6-linked ubiquitination (GO:0085020)4.89501565
19male meiosis (GO:0007140)4.84523670
20establishment of chromosome localization (GO:0051303)4.76170826
21sphingosine metabolic process (GO:0006670)4.75754004
22chaperone-mediated protein transport (GO:0072321)4.67908018
23ATP synthesis coupled proton transport (GO:0015986)4.67658543
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.67658543
25notochord development (GO:0030903)4.67093887
26DNA methylation involved in gamete generation (GO:0043046)4.65157453
27regulation of meiotic cell cycle (GO:0051445)4.56764683
28DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.53157315
29histone H2A ubiquitination (GO:0033522)4.53087377
30regulation of sister chromatid cohesion (GO:0007063)4.52927201
31negative regulation of hormone biosynthetic process (GO:0032353)4.52487181
32negative regulation of hormone metabolic process (GO:0032351)4.52487181
33DNA damage response, signal transduction resulting in transcription (GO:0042772)4.51490273
34protein localization to kinetochore (GO:0034501)4.49118259
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.47355241
36attachment of spindle microtubules to kinetochore (GO:0008608)4.46678652
37regulation of retinoic acid receptor signaling pathway (GO:0048385)4.46548846
38meiotic cell cycle (GO:0051321)4.40960685
39DNA damage induced protein phosphorylation (GO:0006975)4.38743071
40regulation of spindle organization (GO:0090224)4.36616935
41peptidyl-histidine modification (GO:0018202)4.35985566
42regulation of mitochondrial translation (GO:0070129)4.33995092
43protein complex biogenesis (GO:0070271)4.31512644
44respiratory chain complex IV assembly (GO:0008535)4.30883058
45mitochondrial respiratory chain complex assembly (GO:0033108)4.30773557
46mitotic sister chromatid segregation (GO:0000070)4.25191776
47diol metabolic process (GO:0034311)4.24017935
48protein localization to chromosome, centromeric region (GO:0071459)4.22569804
49cytochrome complex assembly (GO:0017004)4.17228446
50GDP-mannose metabolic process (GO:0019673)4.13257070
51maturation of 5.8S rRNA (GO:0000460)4.10748920
52establishment of protein localization to mitochondrial membrane (GO:0090151)4.06995467
53pseudouridine synthesis (GO:0001522)4.05967870
54transcription elongation from RNA polymerase III promoter (GO:0006385)4.02564756
55termination of RNA polymerase III transcription (GO:0006386)4.02564756
56negative regulation of smooth muscle cell differentiation (GO:0051151)3.94316207
57protein localization to chromosome (GO:0034502)3.93378491
58rRNA modification (GO:0000154)3.93215867
59negative regulation of DNA-templated transcription, elongation (GO:0032785)3.91949795
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.91949795
61regulation of mitotic spindle organization (GO:0060236)3.91595908
62regulation of histone H3-K27 methylation (GO:0061085)3.90238699
63female gonad development (GO:0008585)3.89211251
64snRNA transcription (GO:0009301)3.88944539
65metallo-sulfur cluster assembly (GO:0031163)3.87824551
66iron-sulfur cluster assembly (GO:0016226)3.87824551
67respiratory electron transport chain (GO:0022904)3.85920435
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84994891
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.84994891
70NADH dehydrogenase complex assembly (GO:0010257)3.84994891
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83322819
72electron transport chain (GO:0022900)3.82847094
73chromosome segregation (GO:0007059)3.74056797
74mitotic sister chromatid cohesion (GO:0007064)3.72953643
75sister chromatid cohesion (GO:0007062)3.72107474
76protein deneddylation (GO:0000338)3.71505614
77oxidative phosphorylation (GO:0006119)3.67940697
78proteasome assembly (GO:0043248)3.66069815
79negative regulation of keratinocyte proliferation (GO:0010839)3.64461804
80regulation of acrosome reaction (GO:0060046)3.63664570
81GTP biosynthetic process (GO:0006183)3.63467323
82DNA deamination (GO:0045006)3.60003292
83oogenesis (GO:0048477)3.59199810
84microtubule severing (GO:0051013)3.56334614
85sphingoid metabolic process (GO:0046519)3.54149298
86positive regulation of chromosome segregation (GO:0051984)3.52099942
87gene silencing by RNA (GO:0031047)3.51008830
88regulation of transforming growth factor beta2 production (GO:0032909)3.48076010
89regulation of glucocorticoid metabolic process (GO:0031943)3.46941357
90inner cell mass cell proliferation (GO:0001833)3.46286559
91spindle checkpoint (GO:0031577)3.44393950
92glycerophospholipid catabolic process (GO:0046475)3.44081914
93cullin deneddylation (GO:0010388)3.42514435
94regulation of chromosome segregation (GO:0051983)3.41486048
95ribosomal small subunit biogenesis (GO:0042274)3.41117949
96histone lysine demethylation (GO:0070076)3.40616061
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40589934
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40589934
99multicellular organism reproduction (GO:0032504)3.39688384
100negative regulation of meiotic cell cycle (GO:0051447)3.39328376
101sister chromatid segregation (GO:0000819)3.39209599
102ribosomal small subunit assembly (GO:0000028)3.38161818
103DNA alkylation (GO:0006305)3.37802874
104DNA methylation (GO:0006306)3.37802874
105regulation of keratinocyte proliferation (GO:0010837)3.37724803
106histone exchange (GO:0043486)3.37285637
107microtubule nucleation (GO:0007020)3.36372136
108protein targeting to mitochondrion (GO:0006626)3.35339148
109mitochondrial RNA metabolic process (GO:0000959)3.34494987
110regulation of establishment of cell polarity (GO:2000114)3.32113257
111histone demethylation (GO:0016577)3.32087778
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31133599
113male meiosis I (GO:0007141)3.30329814
114base-excision repair, AP site formation (GO:0006285)3.29725933
115UTP biosynthetic process (GO:0006228)3.29637675
116CENP-A containing nucleosome assembly (GO:0034080)3.29478783
117N-terminal protein amino acid acetylation (GO:0006474)3.28365559
118type B pancreatic cell development (GO:0003323)3.24530353
119establishment of protein localization to mitochondrion (GO:0072655)3.24161156
120mannosylation (GO:0097502)3.24079938
121meiosis I (GO:0007127)3.21498437
122meiotic nuclear division (GO:0007126)3.20681672
123regulation of RIG-I signaling pathway (GO:0039535)3.20542020
124guanosine-containing compound biosynthetic process (GO:1901070)3.20529525
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20508627
126negative regulation of cell aging (GO:0090344)3.19656386
127DNA replication-independent nucleosome assembly (GO:0006336)3.19423396
128DNA replication-independent nucleosome organization (GO:0034724)3.19423396
129positive regulation of mitotic sister chromatid separation (GO:1901970)3.19126705
130positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19126705
131positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19126705
132regulation of cellular amino acid metabolic process (GO:0006521)3.19087481
133myoblast migration (GO:0051451)3.19066074
134preassembly of GPI anchor in ER membrane (GO:0016254)3.18601364
135transcription from mitochondrial promoter (GO:0006390)3.18168600
136water-soluble vitamin biosynthetic process (GO:0042364)3.17703029
137negative regulation of reproductive process (GO:2000242)3.17658908
138positive regulation of megakaryocyte differentiation (GO:0045654)3.17362768
139chromatin remodeling at centromere (GO:0031055)3.15860825
140pyrimidine nucleotide catabolic process (GO:0006244)3.15768828
141regulation of double-strand break repair via homologous recombination (GO:0010569)3.13236169
142pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.13220895
143regulation of transcription from RNA polymerase I promoter (GO:0006356)3.12420942
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12375969
145cellular component biogenesis (GO:0044085)3.11785011
146protein demethylation (GO:0006482)3.10653445
147protein dealkylation (GO:0008214)3.10653445
148microtubule depolymerization (GO:0007019)3.10329099
149positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09537235
150branched-chain amino acid catabolic process (GO:0009083)3.08727611
151meiotic cell cycle process (GO:1903046)3.07784802
152purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06573734
153translation (GO:0006412)3.03033619
154ubiquinone biosynthetic process (GO:0006744)3.02805560
155purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02295005
156rRNA methylation (GO:0031167)3.01985209
157deoxyribonucleotide catabolic process (GO:0009264)3.01742019
158viral transcription (GO:0019083)3.01488998
159protein localization to mitochondrion (GO:0070585)3.00488350
160maturation of SSU-rRNA (GO:0030490)2.99372204
161negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98849576
162negative regulation of ligase activity (GO:0051352)2.98849576
163regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98838851
164UTP metabolic process (GO:0046051)2.98549275
165DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98381372
166protein-cofactor linkage (GO:0018065)2.96833735
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94895144
168tRNA processing (GO:0008033)2.94317662
169CTP metabolic process (GO:0046036)2.94298081
170CTP biosynthetic process (GO:0006241)2.94298081
171pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91755514
172signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91548722
173signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91548722
174signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91548722
175positive regulation of prostaglandin secretion (GO:0032308)2.91465772
176deoxyribose phosphate catabolic process (GO:0046386)2.90833688
177rRNA processing (GO:0006364)2.89429388
178telomere maintenance via semi-conservative replication (GO:0032201)2.89330581
179intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88871968
180signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88871968
181pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88387911
182cotranslational protein targeting to membrane (GO:0006613)2.87570613
183translational termination (GO:0006415)2.87562230
184protein targeting to ER (GO:0045047)2.87001414
185translational elongation (GO:0006414)2.86275351
186nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85601334
187ATP biosynthetic process (GO:0006754)2.82977431
188intracellular protein transmembrane import (GO:0044743)2.82839059
189protein localization to endoplasmic reticulum (GO:0070972)2.82592151
190signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82386935
191signal transduction involved in DNA damage checkpoint (GO:0072422)2.82386935
192ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79998066
193rRNA metabolic process (GO:0016072)2.79843747
194protein neddylation (GO:0045116)2.78761900
195positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78103078
196DNA strand elongation involved in DNA replication (GO:0006271)2.77418705
197C-terminal protein lipidation (GO:0006501)2.77207362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.91519585
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47737388
3E2F7_22180533_ChIP-Seq_HELA_Human4.33756809
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.16917097
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.81994080
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.77901961
7KAP1_22055183_ChIP-Seq_ESCs_Mouse3.75551076
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.69695810
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.66723168
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.63548809
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.59967740
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.45112579
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27731691
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.21957643
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19475781
16AR_21909140_ChIP-Seq_LNCAP_Human3.07672679
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98169720
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90764890
19VDR_23849224_ChIP-Seq_CD4+_Human2.82530895
20* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82479771
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78797519
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77624497
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.76707977
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71310926
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66926914
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66491251
27FOXP3_21729870_ChIP-Seq_TREG_Human2.55304276
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51930829
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.41556426
30DCP1A_22483619_ChIP-Seq_HELA_Human2.41517789
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39774535
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39607116
33XRN2_22483619_ChIP-Seq_HELA_Human2.36666291
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29480366
35GABP_19822575_ChIP-Seq_HepG2_Human2.29218507
36GATA1_26923725_Chip-Seq_HPCs_Mouse2.26031396
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20296801
38TP63_19390658_ChIP-ChIP_HaCaT_Human2.11617861
39E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11326860
40FLI1_27457419_Chip-Seq_LIVER_Mouse2.10091692
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07833749
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97431267
43* TTF2_22483619_ChIP-Seq_HELA_Human1.95382945
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94229816
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93243682
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89669142
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87932109
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.86018778
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85349610
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84773011
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83630235
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81785167
53KDM5A_27292631_Chip-Seq_BREAST_Human1.81318797
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80325603
55IGF1R_20145208_ChIP-Seq_DFB_Human1.79704104
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79568027
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79009741
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74940791
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74092933
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72748501
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72349005
62ELK1_19687146_ChIP-ChIP_HELA_Human1.71547572
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71484751
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69955891
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.69734143
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68378085
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67977321
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66171260
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65905784
70RNF2_27304074_Chip-Seq_NSC_Mouse1.64020984
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61697339
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.60992640
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59779912
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58193206
75FUS_26573619_Chip-Seq_HEK293_Human1.58050552
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45687923
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44913959
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44056144
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.43628583
80CIITA_25753668_ChIP-Seq_RAJI_Human1.43257459
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40891158
82STAT1_17558387_ChIP-Seq_HELA_Human1.40552750
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39721233
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37699409
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36351489
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35826193
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35474340
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.35084143
89MYC_18940864_ChIP-ChIP_HL60_Human1.33459979
90NFYA_21822215_ChIP-Seq_K562_Human1.32737827
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32705742
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31355531
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31355531
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.30880090
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30191093
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28696790
97TBL1_22424771_ChIP-Seq_293T_Human1.28395954
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26602042
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.25885315
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25735465
101CDX2_22108803_ChIP-Seq_LS180_Human1.24258291
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23985862
103STAT3_23295773_ChIP-Seq_U87_Human1.22339503
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21399199
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20948164
106AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19781087
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19361986
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17535447
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15151311
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14223324
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14106653
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13504647
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.12938329
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12472070
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12079443
116* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11692792
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11134283
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10430667
119TFEB_21752829_ChIP-Seq_HELA_Human1.09435529
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09429970
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08600803
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08151121
123* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07137074
124HNFA_21074721_ChIP-Seq_CACO-2_Human1.05780736
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.05573315
126ETV1_20927104_ChIP-Seq_GIST48_Human1.05521799
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05455782
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.04182889
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03972164
130ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03968488
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03897950
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03079860
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02810566
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02753687
135ELF1_20517297_ChIP-Seq_JURKAT_Human1.02693309
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02649274
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01641696
138BCL6_27268052_Chip-Seq_Bcells_Human1.01449428
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00853057
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00289816
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99912274
142GATA3_21867929_ChIP-Seq_TH1_Mouse0.99428286
143ZNF274_21170338_ChIP-Seq_K562_Hela0.98587152
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.98151730
145NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97850703
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.97311506
147EWS_26573619_Chip-Seq_HEK293_Human0.96944821
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96588456
149CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96108968
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.95770356
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.95665735
152* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95459481
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94558912
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94516682
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.94402741
156MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94016193
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.93958119
158* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93564207
159E2F1_20622854_ChIP-Seq_HELA_Human0.92927938
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92802785
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92767717
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92267360
163PHF8_20622853_ChIP-Seq_HELA_Human0.92234402
164PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91848836
165P300_27268052_Chip-Seq_Bcells_Human0.91006861
166KDM2B_26808549_Chip-Seq_REH_Human0.90498730
167CTCF_26484167_Chip-Seq_Bcells_Mouse0.90452880
168ERG_20517297_ChIP-Seq_VCAP_Human0.90263327
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.89927114
170OCT4_18555785_Chip-Seq_ESCs_Mouse0.89370023
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89165296
172CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89073886
173NFYB_21822215_ChIP-Seq_K562_Human0.88863321
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.88706818
175FOXH1_21741376_ChIP-Seq_EPCs_Human0.88550350
176KAP1_27257070_Chip-Seq_ESCs_Mouse0.87873607
177PRDM14_20953172_ChIP-Seq_ESCs_Human0.87766975
178ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87520143
179GF1B_26923725_Chip-Seq_HPCs_Mouse0.87438297
180PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86944175
181BCOR_27268052_Chip-Seq_Bcells_Human0.86565169
182EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86403267
183GATA6_21074721_ChIP-Seq_CACO-2_Human0.86374654
184GF1_26923725_Chip-Seq_HPCs_Mouse0.86263314
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86223461
186E2F1_18555785_Chip-Seq_ESCs_Mouse0.86166306
187ELK1_22589737_ChIP-Seq_MCF10A_Human0.85766757
188* TP53_22573176_ChIP-Seq_HFKS_Human0.85099749
189ERA_21632823_ChIP-Seq_H3396_Human0.83372041
190PHF8_20622854_ChIP-Seq_HELA_Human0.83266023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.20257318
2MP0005451_abnormal_body_composition4.89647437
3MP0003646_muscle_fatigue4.64222991
4MP0003693_abnormal_embryo_hatching4.12670211
5MP0002102_abnormal_ear_morphology3.87712996
6MP0003806_abnormal_nucleotide_metabolis3.67962078
7MP0008877_abnormal_DNA_methylation3.66760433
8MP0002653_abnormal_ependyma_morphology3.41504323
9MP0003111_abnormal_nucleus_morphology3.17479474
10MP0006036_abnormal_mitochondrial_physio3.16875391
11MP0004147_increased_porphyrin_level3.14118750
12MP0006292_abnormal_olfactory_placode3.11988400
13MP0010094_abnormal_chromosome_stability3.10651568
14MP0003077_abnormal_cell_cycle3.10272418
15MP0001119_abnormal_female_reproductive2.75518841
16MP0003699_abnormal_female_reproductive2.68012564
17MP0003186_abnormal_redox_activity2.52689400
18MP0001929_abnormal_gametogenesis2.41351793
19MP0005395_other_phenotype2.41246896
20MP0003787_abnormal_imprinting2.38244701
21MP0006035_abnormal_mitochondrial_morpho2.38082963
22MP0003786_premature_aging2.34246892
23MP0005408_hypopigmentation2.25688726
24MP0004957_abnormal_blastocyst_morpholog2.24603234
25MP0000653_abnormal_sex_gland2.20538264
26MP0003937_abnormal_limbs/digits/tail_de2.15087086
27MP0001764_abnormal_homeostasis2.12271517
28MP0002210_abnormal_sex_determination2.11021614
29MP0000579_abnormal_nail_morphology2.03725426
30MP0009333_abnormal_splenocyte_physiolog2.00256043
31MP0005083_abnormal_biliary_tract1.97176834
32MP0002249_abnormal_larynx_morphology1.89890878
33MP0003123_paternal_imprinting1.87226092
34MP0005645_abnormal_hypothalamus_physiol1.86666411
35MP0005075_abnormal_melanosome_morpholog1.82373961
36MP0008875_abnormal_xenobiotic_pharmacok1.78624831
37MP0005084_abnormal_gallbladder_morpholo1.77278217
38MP0003195_calcinosis1.76326652
39MP0008007_abnormal_cellular_replicative1.74317846
40MP0001529_abnormal_vocalization1.72101278
41MP0005332_abnormal_amino_acid1.71386944
42MP0004185_abnormal_adipocyte_glucose1.70184100
43MP0002837_dystrophic_cardiac_calcinosis1.67388577
44MP0003121_genomic_imprinting1.63183184
45MP0001145_abnormal_male_reproductive1.54313971
46MP0005220_abnormal_exocrine_pancreas1.53859239
47MP0000566_synostosis1.52299571
48MP0005646_abnormal_pituitary_gland1.51470594
49MP0000350_abnormal_cell_proliferation1.48753728
50MP0002876_abnormal_thyroid_physiology1.48601082
51MP0003315_abnormal_perineum_morphology1.48268619
52MP0008932_abnormal_embryonic_tissue1.46870038
53MP0008057_abnormal_DNA_replication1.46503977
54MP0002161_abnormal_fertility/fecundity1.45635347
55MP0002085_abnormal_embryonic_tissue1.43304212
56MP0001661_extended_life_span1.42641908
57MP0008872_abnormal_physiological_respon1.42567757
58MP0000358_abnormal_cell_content/1.41417088
59MP0001968_abnormal_touch/_nociception1.40754689
60MP0001730_embryonic_growth_arrest1.38517600
61MP0000015_abnormal_ear_pigmentation1.38393087
62MP0002693_abnormal_pancreas_physiology1.36096069
63MP0005310_abnormal_salivary_gland1.34084757
64MP0005636_abnormal_mineral_homeostasis1.32363899
65MP0005671_abnormal_response_to1.31232655
66MP0000639_abnormal_adrenal_gland1.27013667
67MP0008058_abnormal_DNA_repair1.23719096
68MP0002095_abnormal_skin_pigmentation1.22975245
69MP0001915_intracranial_hemorrhage1.22026370
70MP0005365_abnormal_bile_salt1.21687204
71MP0001346_abnormal_lacrimal_gland1.21549273
72MP0002084_abnormal_developmental_patter1.20003419
73MP0000462_abnormal_digestive_system1.18550084
74MP0005187_abnormal_penis_morphology1.17670997
75MP0001905_abnormal_dopamine_level1.16475547
76MP0001697_abnormal_embryo_size1.16019682
77MP0005380_embryogenesis_phenotype1.14992176
78MP0001672_abnormal_embryogenesis/_devel1.14992176
79MP0003950_abnormal_plasma_membrane1.13041164
80MP0001944_abnormal_pancreas_morphology1.09967952
81MP0002277_abnormal_respiratory_mucosa1.05883742
82MP0002139_abnormal_hepatobiliary_system1.05344810
83MP0002148_abnormal_hypersensitivity_rea1.05074227
84MP0009697_abnormal_copulation1.04333539
85MP0003755_abnormal_palate_morphology1.03314196
86MP0008260_abnormal_autophagy1.02705422
87MP0002938_white_spotting1.02578025
88MP0001727_abnormal_embryo_implantation1.02142834
89MP0004043_abnormal_pH_regulation1.01386462
90MP0001851_eye_inflammation1.00584532
91MP0003890_abnormal_embryonic-extraembry0.99867291
92MP0004264_abnormal_extraembryonic_tissu0.99842442
93MP0010368_abnormal_lymphatic_system0.98557714
94MP0000689_abnormal_spleen_morphology0.97811841
95MP0002877_abnormal_melanocyte_morpholog0.94219534
96MP0003698_abnormal_male_reproductive0.94132860
97MP0005551_abnormal_eye_electrophysiolog0.93924526
98MP0002163_abnormal_gland_morphology0.92778305
99MP0005174_abnormal_tail_pigmentation0.92545659
100MP0002234_abnormal_pharynx_morphology0.92324742
101MP0010329_abnormal_lipoprotein_level0.92218488
102MP0005410_abnormal_fertilization0.91840452
103MP0001986_abnormal_taste_sensitivity0.91489623
104MP0001873_stomach_inflammation0.90304682
105MP0005253_abnormal_eye_physiology0.90204976
106MP0002132_abnormal_respiratory_system0.89556449
107MP0009250_abnormal_appendicular_skeleto0.89326535
108MP0002398_abnormal_bone_marrow0.88432649
109MP0001919_abnormal_reproductive_system0.88190945
110MP0000313_abnormal_cell_death0.87986907
111MP0009643_abnormal_urine_homeostasis0.87430268
112MP0000490_abnormal_crypts_of0.87293657
113MP0005266_abnormal_metabolism0.87159113
114MP0002722_abnormal_immune_system0.86434846
115MP0002736_abnormal_nociception_after0.85196936
116MP0002019_abnormal_tumor_incidence0.84298024
117MP0010386_abnormal_urinary_bladder0.83932939
118MP0010307_abnormal_tumor_latency0.83809550
119MP0000685_abnormal_immune_system0.83466851
120MP0002638_abnormal_pupillary_reflex0.83099719
121MP0005257_abnormal_intraocular_pressure0.81065331
122MP0000372_irregular_coat_pigmentation0.80950488
123MP0005647_abnormal_sex_gland0.80199963
124MP0002429_abnormal_blood_cell0.79889317
125MP0005085_abnormal_gallbladder_physiolo0.79617741
126MP0005389_reproductive_system_phenotype0.79545642
127MP0005621_abnormal_cell_physiology0.78786354
128MP0002078_abnormal_glucose_homeostasis0.78320871
129MP0002177_abnormal_outer_ear0.78241850
130MP0003011_delayed_dark_adaptation0.77115104
131MP0003984_embryonic_growth_retardation0.76641261
132MP0005319_abnormal_enzyme/_coenzyme0.75674566
133MP0005330_cardiomyopathy0.75594727
134MP0002909_abnormal_adrenal_gland0.75213737
135MP0000703_abnormal_thymus_morphology0.73745291
136MP0000613_abnormal_salivary_gland0.73602988
137MP0005197_abnormal_uvea_morphology0.73523433
138MP0005058_abnormal_lysosome_morphology0.73316048
139MP0000432_abnormal_head_morphology0.72422288
140MP0002295_abnormal_pulmonary_circulatio0.72153820
141MP0002723_abnormal_immune_serum0.71959470
142MP0003935_abnormal_craniofacial_develop0.71535637
143MP0005448_abnormal_energy_balance0.71220958
144MP0001881_abnormal_mammary_gland0.71069069
145MP0002088_abnormal_embryonic_growth/wei0.71004962
146MP0003632_abnormal_nervous_system0.70691686
147MP0000427_abnormal_hair_cycle0.70616687
148MP0003656_abnormal_erythrocyte_physiolo0.69986148
149MP0005584_abnormal_enzyme/coenzyme_acti0.69242621
150MP0000716_abnormal_immune_system0.69067158
151MP0002420_abnormal_adaptive_immunity0.68879914
152MP0002233_abnormal_nose_morphology0.67235932
153MP0001849_ear_inflammation0.66632997
154MP0003861_abnormal_nervous_system0.66258941
155MP0009384_cardiac_valve_regurgitation0.65236743
156MP0002116_abnormal_craniofacial_bone0.64664656
157MP0002080_prenatal_lethality0.63303910
158MP0005248_abnormal_Harderian_gland0.62975686
159MP0000538_abnormal_urinary_bladder0.61313268
160MP0003938_abnormal_ear_development0.60985910
161MP0002086_abnormal_extraembryonic_tissu0.60020747
162MP0006072_abnormal_retinal_apoptosis0.59288179
163MP0000631_abnormal_neuroendocrine_gland0.59057878
164MP0005379_endocrine/exocrine_gland_phen0.56799385
165MP0003763_abnormal_thymus_physiology0.55205871
166MP0002109_abnormal_limb_morphology0.54144710
167MP0002932_abnormal_joint_morphology0.53987320
168MP0002160_abnormal_reproductive_system0.53598420
169MP0000465_gastrointestinal_hemorrhage0.53039591
170MP0005384_cellular_phenotype0.52610443
171MP0008995_early_reproductive_senescence0.51330386

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.06146355
2Papillary thyroid carcinoma (HP:0002895)6.11915636
3Birth length less than 3rd percentile (HP:0003561)5.04409614
4Chromsome breakage (HP:0040012)4.96101853
5Facial hemangioma (HP:0000329)4.89731285
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85849557
7Shawl scrotum (HP:0000049)4.46407804
8Breast hypoplasia (HP:0003187)4.36382583
9Patellar aplasia (HP:0006443)4.29427259
10Mitochondrial inheritance (HP:0001427)4.26151251
11Flat capital femoral epiphysis (HP:0003370)4.17467493
12Abnormality of the labia minora (HP:0012880)4.17131844
13Acute necrotizing encephalopathy (HP:0006965)4.12653723
14Premature ovarian failure (HP:0008209)4.03528510
15Abnormal mitochondria in muscle tissue (HP:0008316)3.99461490
16Acute encephalopathy (HP:0006846)3.93702622
17Aplasia/Hypoplasia of the patella (HP:0006498)3.93343665
18Hepatic necrosis (HP:0002605)3.93085934
19Increased CSF lactate (HP:0002490)3.91880954
20Hepatocellular necrosis (HP:0001404)3.87678564
21Increased hepatocellular lipid droplets (HP:0006565)3.78677671
22Capillary hemangiomas (HP:0005306)3.78413687
23Adrenal hypoplasia (HP:0000835)3.75316731
24Lipid accumulation in hepatocytes (HP:0006561)3.74694545
25Increased intramyocellular lipid droplets (HP:0012240)3.74054412
26Abnormality of the fingertips (HP:0001211)3.66451596
27Infertility (HP:0000789)3.53715327
28Renal Fanconi syndrome (HP:0001994)3.52797937
29Breast aplasia (HP:0100783)3.50309528
30Progressive macrocephaly (HP:0004481)3.50050092
31Abnormal number of erythroid precursors (HP:0012131)3.49411393
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.44372200
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.44372200
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.43609603
35Increased muscle lipid content (HP:0009058)3.38697397
36Thyroid carcinoma (HP:0002890)3.33922207
37Prostate neoplasm (HP:0100787)3.32470709
383-Methylglutaconic aciduria (HP:0003535)3.31252292
39Lactic acidosis (HP:0003128)3.24942890
40Abnormality of cells of the erythroid lineage (HP:0012130)3.23449005
41Increased serum lactate (HP:0002151)3.15002998
42Acute myeloid leukemia (HP:0004808)3.13838060
43Type I transferrin isoform profile (HP:0003642)3.07639614
44Secondary amenorrhea (HP:0000869)3.04798078
45Cortical dysplasia (HP:0002539)3.03923268
46Cerebral edema (HP:0002181)3.01925949
47Oligodactyly (hands) (HP:0001180)3.01593647
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.99117917
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98515300
50Abnormality of alanine metabolism (HP:0010916)2.95361772
51Hyperalaninemia (HP:0003348)2.95361772
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95361772
53Abnormality of chromosome stability (HP:0003220)2.93911475
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.91666593
55Hypoplasia of the fovea (HP:0007750)2.91666593
56Abnormality of chromosome segregation (HP:0002916)2.89432977
57Abnormality of lateral ventricle (HP:0030047)2.88029292
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.87919363
59Lip pit (HP:0100267)2.85626284
60Oligodactyly (HP:0012165)2.79200286
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77711931
62Dicarboxylic aciduria (HP:0003215)2.77711931
63Abnormality of the preputium (HP:0100587)2.77230785
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75748115
65Arterial tortuosity (HP:0005116)2.75609037
66Abnormal protein glycosylation (HP:0012346)2.71998972
67Abnormal glycosylation (HP:0012345)2.71998972
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71998972
69Abnormal protein N-linked glycosylation (HP:0012347)2.71998972
70Meckel diverticulum (HP:0002245)2.68231609
71Ectopic kidney (HP:0000086)2.64719493
72Abnormality of the fovea (HP:0000493)2.62439476
73Overlapping toe (HP:0001845)2.61615740
74Exercise intolerance (HP:0003546)2.60306946
75Ketoacidosis (HP:0001993)2.60081774
76Methylmalonic acidemia (HP:0002912)2.58021879
77Anterior segment dysgenesis (HP:0007700)2.56613449
78Testicular atrophy (HP:0000029)2.56322990
79Reduced antithrombin III activity (HP:0001976)2.56157137
80Methylmalonic aciduria (HP:0012120)2.53835243
81Insulin-resistant diabetes mellitus (HP:0000831)2.52368035
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.51375537
83Sandal gap (HP:0001852)2.51357009
84Sparse lateral eyebrow (HP:0005338)2.50937644
85Ketosis (HP:0001946)2.50587394
86Abnormality of the ileum (HP:0001549)2.47331313
87Microvesicular hepatic steatosis (HP:0001414)2.43606731
88Lethargy (HP:0001254)2.43386968
89Exertional dyspnea (HP:0002875)2.42430670
90Reticulocytopenia (HP:0001896)2.40083462
91Hypergonadotropic hypogonadism (HP:0000815)2.36828201
92Primary amenorrhea (HP:0000786)2.34832141
93Pancytopenia (HP:0001876)2.34056464
94Vascular tortuosity (HP:0004948)2.33522143
95Respiratory failure (HP:0002878)2.32828803
96Spondylolisthesis (HP:0003302)2.31808921
97Carpal bone hypoplasia (HP:0001498)2.30389281
98Duodenal stenosis (HP:0100867)2.30269241
99Small intestinal stenosis (HP:0012848)2.30269241
100Hyperglycinemia (HP:0002154)2.29724301
101Progressive microcephaly (HP:0000253)2.28984131
102Myelodysplasia (HP:0002863)2.27472287
103Microretrognathia (HP:0000308)2.26850611
104Optic disc pallor (HP:0000543)2.23761566
105Sensorimotor neuropathy (HP:0007141)2.22899284
106Respiratory difficulties (HP:0002880)2.22816792
107Clubbing of toes (HP:0100760)2.22450430
108Abnormality of the phalanges of the hallux (HP:0010057)2.21677944
109Aplasia/hypoplasia of the uterus (HP:0008684)2.20177527
110Microglossia (HP:0000171)2.19723405
111Pulmonary fibrosis (HP:0002206)2.19578880
112Glycosuria (HP:0003076)2.19236860
113Abnormality of urine glucose concentration (HP:0011016)2.19236860
114Abnormality of serum amino acid levels (HP:0003112)2.17606997
115Cystic hygroma (HP:0000476)2.17415743
116Supernumerary spleens (HP:0009799)2.16721069
117Generalized aminoaciduria (HP:0002909)2.14836425
118Abnormality of the heme biosynthetic pathway (HP:0010472)2.13812220
119Abnormality of the epiphysis of the femoral head (HP:0010574)2.09398333
120Brushfield spots (HP:0001088)2.08991367
121Macrocytic anemia (HP:0001972)2.08183286
122Abnormality of methionine metabolism (HP:0010901)2.07742575
123Cerebral palsy (HP:0100021)2.07709689
124Posterior embryotoxon (HP:0000627)2.07421730
125Aplastic anemia (HP:0001915)2.07367017
126Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07248960
127Short thumb (HP:0009778)2.06746064
128Rib fusion (HP:0000902)2.06253785
129Midline defect of the nose (HP:0004122)2.05657511
130Abnormality of renal resorption (HP:0011038)2.05320455
131Hypoplasia of the uterus (HP:0000013)2.04966934
132Spontaneous abortion (HP:0005268)2.04578650
133Hypoplastic iliac wings (HP:0002866)2.04568502
134Absent thumb (HP:0009777)2.03803821
135Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03471397
136Hyperglycemia (HP:0003074)2.02840030
137Abnormality of fatty-acid metabolism (HP:0004359)2.02573529
138Hypoglycemic coma (HP:0001325)2.01438564
139Sloping forehead (HP:0000340)2.01047299
140Abnormality of the line of Schwalbe (HP:0008048)2.00704334
141Abnormality of the carotid arteries (HP:0005344)2.00380669
142Nephroblastoma (Wilms tumor) (HP:0002667)1.99757598
143Absent radius (HP:0003974)1.99359520
144Abnormality of the femoral head (HP:0003368)1.97101448
145Chronic bronchitis (HP:0004469)1.95593990
146CNS demyelination (HP:0007305)1.95150762
147Deep venous thrombosis (HP:0002625)1.95133299
148Aplasia involving forearm bones (HP:0009822)1.92413714
149Absent forearm bone (HP:0003953)1.92413714
150Large for gestational age (HP:0001520)1.92088077
151Pallor (HP:0000980)1.91821759
152Wrist flexion contracture (HP:0001239)1.91328715
153Abnormality of the prostate (HP:0008775)1.89884615
154True hermaphroditism (HP:0010459)1.89529599
155Pancreatic fibrosis (HP:0100732)1.89376668
156Metabolic acidosis (HP:0001942)1.88572862
157Molar tooth sign on MRI (HP:0002419)1.87571236
158Abnormality of midbrain morphology (HP:0002418)1.87571236
159Abnormality of femoral epiphyses (HP:0006499)1.87390879
160Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87390879
161Cafe-au-lait spot (HP:0000957)1.87318798
162Abnormality of the proximal phalanges of the hand (HP:0009834)1.87268224
163Petechiae (HP:0000967)1.87056661
164Aplasia/Hypoplasia of the macula (HP:0008059)1.86424060
165Increased serum pyruvate (HP:0003542)1.86003761
166Pancreatic cysts (HP:0001737)1.85519339
167Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84397735
168Embryonal renal neoplasm (HP:0011794)1.83556608
169Hyperammonemia (HP:0001987)1.83451447
170Panhypogammaglobulinemia (HP:0003139)1.82423387
171Neutropenia (HP:0001875)1.81966497
172Abnormality of glycolysis (HP:0004366)1.81234297
173Erectile abnormalities (HP:0100639)1.80563718
174Abnormality of the duodenum (HP:0002246)1.79771942
175Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79389339
176Leukodystrophy (HP:0002415)1.78914578
177IgG deficiency (HP:0004315)1.78852658
178Severe combined immunodeficiency (HP:0004430)1.77739167
179Camptodactyly of toe (HP:0001836)1.76604035
180Chin dimple (HP:0010751)1.76575902
181Nonprogressive disorder (HP:0003680)1.75373017
182Abnormality of DNA repair (HP:0003254)1.75077519
183Hyperinsulinemic hypoglycemia (HP:0000825)1.74937424
184Squamous cell carcinoma (HP:0002860)1.74916291
185Azoospermia (HP:0000027)1.74794984
186Abnormality of cochlea (HP:0000375)1.73290550
187Abnormal spermatogenesis (HP:0008669)1.72811142
188Opisthotonus (HP:0002179)1.72719194
189Abnormality of the labia (HP:0000058)1.72522799
190Hyperphosphaturia (HP:0003109)1.72304164
191Hypoplasia of the pons (HP:0012110)1.71451216
192Neoplasm of the adrenal gland (HP:0100631)1.70042749
193Spastic paraparesis (HP:0002313)1.69621785
194Impulsivity (HP:0100710)1.68134583
195Hyperglycinuria (HP:0003108)1.68064094
196Abnormality of serine family amino acid metabolism (HP:0010894)1.67978882
197Abnormality of glycine metabolism (HP:0010895)1.67978882
198Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66891299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.44069829
2LATS25.29008375
3STK38L4.66304839
4VRK24.65885182
5MAP3K63.88839123
6ERBB43.41004705
7ZAK3.33333606
8NME23.33128865
9BCKDK3.27740604
10STK163.21934239
11PLK42.85884748
12TLK12.83862181
13MUSK2.75792125
14TTK2.68323587
15KSR22.64267446
16TESK22.50126399
17PIM22.44078683
18CDC72.43423265
19BRAF2.23999681
20TAOK32.22628952
21EEF2K2.19234959
22STK32.18319300
23MAP3K92.16631395
24TAOK12.12368883
25RAF11.98757470
26CDK81.89658950
27MAP3K131.88581407
28INSRR1.82804385
29KDR1.75439493
30EIF2AK11.70460246
31CCNB11.68624164
32STK381.63676127
33CHEK21.59141175
34MAP4K21.56649552
35PDK21.55868299
36MOS1.54466374
37NME11.54393262
38MAP3K111.51993053
39MELK1.49646724
40PBK1.47830815
41TRIM281.47655272
42PAK61.43883117
43PRKD31.36898087
44TSSK61.36558476
45ARAF1.34691224
46TXK1.33945610
47GRK11.32572409
48NEK21.32363816
49ABL21.31746331
50MAPKAPK31.30084001
51GRK61.27170847
52SCYL21.26524568
53RPS6KA51.26265368
54ADRBK21.26037279
55MAPK131.23262647
56MST41.22668446
57MAP3K41.19370384
58MAP3K121.19316829
59PLK11.17735948
60DAPK11.10857523
61KSR11.10661127
62CDK91.10574865
63DYRK21.05515381
64WNK41.03108238
65IKBKB1.02594902
66DMPK1.02070428
67CAMKK20.99076147
68LIMK10.96194230
69TAF10.94888161
70MAP2K20.94706302
71TESK10.93224227
72STK100.91103207
73NUAK10.89077730
74PASK0.87840559
75ILK0.87044067
76MAPKAPK50.86832168
77BMPR20.86348261
78IRAK30.85756268
79TYRO30.82713106
80PRKD20.82299852
81ACVR1B0.81722270
82MAP2K70.77617357
83PIM10.76893063
84AURKB0.74989819
85PRKCI0.74021273
86DAPK20.73447261
87PHKG20.73077578
88PHKG10.73077578
89SRPK10.72445720
90PRKAA20.72144449
91MAP3K80.69465215
92WNK30.67927388
93NEK10.65124163
94CDK120.64555000
95PRKAA10.61945684
96MARK20.61084513
97ATM0.59740648
98MAP2K60.59614837
99STK240.59184496
100PLK30.58116161
101CSNK1G10.57304519
102CHEK10.56728999
103DAPK30.55930568
104AURKA0.55923543
105MAP2K40.55785258
106CSNK2A20.54810780
107BRSK20.54322729
108RET0.53987056
109CSNK2A10.53633309
110LRRK20.53434762
111MAP4K10.52274076
112MAP3K50.51816114
113NTRK20.51664738
114WEE10.51425325
115ABL10.49831811
116BUB10.48700397
117CDK30.48566820
118TRPM70.47554872
119PINK10.47515750
120TNK20.46834079
121TEC0.44832094
122STK40.43380787
123JAK30.42589310
124PRKCQ0.42428580
125BRSK10.42216787
126CSNK1G20.41948030
127SMG10.40242911
128CDK70.39959656
129MAPK110.39518861
130EPHA30.38522863
131CDK190.38300049
132PDGFRB0.37228149
133FES0.36126119
134TBK10.35312093
135VRK10.34575196
136CLK10.34475841
137MAPK150.34030036
138CAMK1D0.33472517
139CDK10.33305364
140NLK0.33117548
141EIF2AK30.32428720
142CSNK1G30.31900835
143MAPK100.31162979
144CDK20.30921876
145RPS6KB20.29183276
146NEK90.29018523
147CDK40.26296500
148MAP3K10.25916855
149SGK20.24216504
150BMPR1B0.22903769
151CSNK1D0.22360059
152CSNK1A1L0.21606022
153CAMK2A0.19744185
154JAK20.16231209
155HIPK20.15923961
156FRK0.15778490
157ATR0.15543190
158AKT10.14222113
159CHUK0.13412131
160PLK20.13219651
161MAPK140.11559200
162DYRK30.11148987
163GSK3B0.11131621
164SGK2230.10626902

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.18625639
2Basal transcription factors_Homo sapiens_hsa030223.64602416
3Vitamin B6 metabolism_Homo sapiens_hsa007503.54418362
4Oxidative phosphorylation_Homo sapiens_hsa001903.49457723
5Proteasome_Homo sapiens_hsa030503.46460438
6RNA degradation_Homo sapiens_hsa030183.43519793
7Ribosome_Homo sapiens_hsa030103.35534262
8Ovarian steroidogenesis_Homo sapiens_hsa049132.96954864
9Parkinsons disease_Homo sapiens_hsa050122.94096894
10Circadian rhythm_Homo sapiens_hsa047102.72559914
11Fanconi anemia pathway_Homo sapiens_hsa034602.68688514
12Homologous recombination_Homo sapiens_hsa034402.60302059
13Pancreatic cancer_Homo sapiens_hsa052122.31050052
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22803349
15RNA polymerase_Homo sapiens_hsa030202.16056946
16Oocyte meiosis_Homo sapiens_hsa041142.10218165
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.06738139
18TGF-beta signaling pathway_Homo sapiens_hsa043502.02495090
19p53 signaling pathway_Homo sapiens_hsa041151.94499790
20Huntingtons disease_Homo sapiens_hsa050161.88896459
21Protein export_Homo sapiens_hsa030601.88457578
22One carbon pool by folate_Homo sapiens_hsa006701.83986517
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80672591
24RNA transport_Homo sapiens_hsa030131.77443802
25Fatty acid elongation_Homo sapiens_hsa000621.77441134
26Alzheimers disease_Homo sapiens_hsa050101.77421205
27Linoleic acid metabolism_Homo sapiens_hsa005911.76478615
28Other glycan degradation_Homo sapiens_hsa005111.73274940
29Ether lipid metabolism_Homo sapiens_hsa005651.71205301
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70942633
31Sulfur relay system_Homo sapiens_hsa041221.68197467
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67886669
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64436412
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62822034
35Prolactin signaling pathway_Homo sapiens_hsa049171.62025212
36MicroRNAs in cancer_Homo sapiens_hsa052061.60181145
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55340782
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54818434
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51400704
40Peroxisome_Homo sapiens_hsa041461.45010235
41GnRH signaling pathway_Homo sapiens_hsa049121.44430770
42Dorso-ventral axis formation_Homo sapiens_hsa043201.42317127
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.42026430
44Choline metabolism in cancer_Homo sapiens_hsa052311.37823540
45Colorectal cancer_Homo sapiens_hsa052101.37694803
46Sulfur metabolism_Homo sapiens_hsa009201.35649371
47Propanoate metabolism_Homo sapiens_hsa006401.35398941
48Non-homologous end-joining_Homo sapiens_hsa034501.34740096
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32734075
50Spliceosome_Homo sapiens_hsa030401.32535670
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32141196
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31512124
53Butanoate metabolism_Homo sapiens_hsa006501.30833749
54Renal cell carcinoma_Homo sapiens_hsa052111.25174887
55Pyruvate metabolism_Homo sapiens_hsa006201.24969535
56mRNA surveillance pathway_Homo sapiens_hsa030151.23268980
57Sphingolipid metabolism_Homo sapiens_hsa006001.21099962
58Glutathione metabolism_Homo sapiens_hsa004801.17599585
59Thyroid cancer_Homo sapiens_hsa052161.15858738
60Folate biosynthesis_Homo sapiens_hsa007901.12350706
61Mismatch repair_Homo sapiens_hsa034301.10542568
62Selenocompound metabolism_Homo sapiens_hsa004501.09779405
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08373000
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08295033
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08028140
66Lysine degradation_Homo sapiens_hsa003101.07169389
67Nucleotide excision repair_Homo sapiens_hsa034201.07157052
68Collecting duct acid secretion_Homo sapiens_hsa049661.06733783
69Primary immunodeficiency_Homo sapiens_hsa053401.04197189
70Base excision repair_Homo sapiens_hsa034101.03311592
71Pentose phosphate pathway_Homo sapiens_hsa000300.99060216
72Metabolic pathways_Homo sapiens_hsa011000.97615024
73FoxO signaling pathway_Homo sapiens_hsa040680.93938491
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.92268959
75Endometrial cancer_Homo sapiens_hsa052130.91989448
76Hippo signaling pathway_Homo sapiens_hsa043900.91206605
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90368894
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89381239
79Carbon metabolism_Homo sapiens_hsa012000.89190585
80mTOR signaling pathway_Homo sapiens_hsa041500.85715491
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84440703
82Tryptophan metabolism_Homo sapiens_hsa003800.84316526
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83970703
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83893868
85Fructose and mannose metabolism_Homo sapiens_hsa000510.82503886
86VEGF signaling pathway_Homo sapiens_hsa043700.81542242
87Ras signaling pathway_Homo sapiens_hsa040140.80753953
88Cardiac muscle contraction_Homo sapiens_hsa042600.80352723
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79790039
90Adherens junction_Homo sapiens_hsa045200.79552832
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78422388
92Non-small cell lung cancer_Homo sapiens_hsa052230.78129152
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77950980
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77538388
95Small cell lung cancer_Homo sapiens_hsa052220.75624239
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75166593
97ErbB signaling pathway_Homo sapiens_hsa040120.73814386
98N-Glycan biosynthesis_Homo sapiens_hsa005100.73719611
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.71662166
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.71303016
101Prostate cancer_Homo sapiens_hsa052150.71252990
102Hepatitis B_Homo sapiens_hsa051610.71195233
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70796169
104Chronic myeloid leukemia_Homo sapiens_hsa052200.69884037
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69549670
106DNA replication_Homo sapiens_hsa030300.68316440
107Inositol phosphate metabolism_Homo sapiens_hsa005620.68038831
108Caffeine metabolism_Homo sapiens_hsa002320.67804215
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67488140
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.67176336
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67175796
112Fatty acid metabolism_Homo sapiens_hsa012120.64968096
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64615005
114Nitrogen metabolism_Homo sapiens_hsa009100.64291061
115Long-term depression_Homo sapiens_hsa047300.63444381
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.62653380
117Chemical carcinogenesis_Homo sapiens_hsa052040.61078553
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.59634117
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58113030
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57567707
121Bladder cancer_Homo sapiens_hsa052190.57042145
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.56795730
123Estrogen signaling pathway_Homo sapiens_hsa049150.56120540
124Pyrimidine metabolism_Homo sapiens_hsa002400.55795418
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54004579
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53848337
127Herpes simplex infection_Homo sapiens_hsa051680.52611801
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52251417
129Melanoma_Homo sapiens_hsa052180.52077936
130Systemic lupus erythematosus_Homo sapiens_hsa053220.50894345
131Glioma_Homo sapiens_hsa052140.49204378
132MAPK signaling pathway_Homo sapiens_hsa040100.48630849
133Notch signaling pathway_Homo sapiens_hsa043300.48355067
134Phototransduction_Homo sapiens_hsa047440.46508683
135Type I diabetes mellitus_Homo sapiens_hsa049400.45418566
136HTLV-I infection_Homo sapiens_hsa051660.43896744
137Steroid biosynthesis_Homo sapiens_hsa001000.43328169
138cAMP signaling pathway_Homo sapiens_hsa040240.42265382
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.40259979
140Arachidonic acid metabolism_Homo sapiens_hsa005900.40245491
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40104652
142Vitamin digestion and absorption_Homo sapiens_hsa049770.40025808
143Wnt signaling pathway_Homo sapiens_hsa043100.38943503
144Arginine and proline metabolism_Homo sapiens_hsa003300.37567074
145Fatty acid degradation_Homo sapiens_hsa000710.37069973
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.37063272
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36178430
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35576219
149Pathways in cancer_Homo sapiens_hsa052000.35389240
150Arginine biosynthesis_Homo sapiens_hsa002200.35150567
151Phenylalanine metabolism_Homo sapiens_hsa003600.34924667
152Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34845815
153beta-Alanine metabolism_Homo sapiens_hsa004100.34241300
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.32809891
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32630384
156Serotonergic synapse_Homo sapiens_hsa047260.32536664
157* Purine metabolism_Homo sapiens_hsa002300.31923484
158Tyrosine metabolism_Homo sapiens_hsa003500.31086846
159Shigellosis_Homo sapiens_hsa051310.30743699
160Galactose metabolism_Homo sapiens_hsa000520.30690689
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30273024
162Jak-STAT signaling pathway_Homo sapiens_hsa046300.30038310
163Vibrio cholerae infection_Homo sapiens_hsa051100.30035953
164Hedgehog signaling pathway_Homo sapiens_hsa043400.29804323
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.29499511
166Regulation of autophagy_Homo sapiens_hsa041400.28355156
167TNF signaling pathway_Homo sapiens_hsa046680.27908067
168AMPK signaling pathway_Homo sapiens_hsa041520.25728815
169Biosynthesis of amino acids_Homo sapiens_hsa012300.24896910
170Viral carcinogenesis_Homo sapiens_hsa052030.23527439
171Glutamatergic synapse_Homo sapiens_hsa047240.22770272
172Influenza A_Homo sapiens_hsa051640.21822646
173Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20326895

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