ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cholesterol biosynthetic process (GO:0006695)	5.22240242
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.93932930
3	sterol biosynthetic process (GO:0016126)	4.78730619
4	L-serine metabolic process (GO:0006563)	4.54661573
5	isoprenoid biosynthetic process (GO:0008299)	4.44382000
6	sulfur amino acid catabolic process (GO:0000098)	4.26435878
7	regulation of development, heterochronic (GO:0040034)	4.17212782
8	regulation of Golgi to plasma membrane protein transport (GO:0042996)	4.15116851
9	positive regulation of mitochondrial fission (GO:0090141)	4.11707530
10	nonmotile primary cilium assembly (GO:0035058)	4.05839504
11	serine family amino acid catabolic process (GO:0009071)	4.02655067
12	sequestering of actin monomers (GO:0042989)	3.92117124
13	glial cell proliferation (GO:0014009)	3.84747669
14	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.82129016
15	glyoxylate metabolic process (GO:0046487)	3.81103360
16	fatty acid elongation (GO:0030497)	3.76627105
17	cysteine metabolic process (GO:0006534)	3.64044104
18	pyrimidine dimer repair (GO:0006290)	3.63471107
19	nucleobase catabolic process (GO:0046113)	3.61763033
20	DNA damage response, detection of DNA damage (GO:0042769)	3.58572285
21	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.52930653
22	glycolytic process (GO:0006096)	3.47026804
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.42539450
24	regulation of cilium movement (GO:0003352)	3.41044392
25	positive regulation of receptor biosynthetic process (GO:0010870)	3.39020569
26	pyrimidine nucleotide catabolic process (GO:0006244)	3.37188080
27	base-excision repair, AP site formation (GO:0006285)	3.37118238
28	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.36197313
29	serine family amino acid metabolic process (GO:0009069)	3.30101898
30	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.28673382
31	ubiquinone metabolic process (GO:0006743)	3.24853575
32	amino acid salvage (GO:0043102)	3.21360558
33	L-methionine salvage (GO:0071267)	3.21360558
34	L-methionine biosynthetic process (GO:0071265)	3.21360558
35	serine family amino acid biosynthetic process (GO:0009070)	3.20969392
36	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.20607719
37	alpha-linolenic acid metabolic process (GO:0036109)	3.20370558
38	protein neddylation (GO:0045116)	3.18604501
39	aldehyde catabolic process (GO:0046185)	3.17415065
40	platelet dense granule organization (GO:0060155)	3.16153095
41	mitochondrial calcium ion transport (GO:0006851)	3.10851421
42	amino-acid betaine metabolic process (GO:0006577)	3.10166368
43	thrombin receptor signaling pathway (GO:0070493)	3.03898442
44	spinal cord association neuron differentiation (GO:0021527)	3.03683582
45	regulation of timing of cell differentiation (GO:0048505)	3.00623369
46	cerebral cortex neuron differentiation (GO:0021895)	2.99289100
47	iron-sulfur cluster assembly (GO:0016226)	2.95360671
48	metallo-sulfur cluster assembly (GO:0031163)	2.95360671
49	polyamine biosynthetic process (GO:0006596)	2.92108407
50	DNA integration (GO:0015074)	2.91205164
51	L-phenylalanine catabolic process (GO:0006559)	2.90861251
52	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.90861251
53	peptidyl-arginine omega-N-methylation (GO:0035247)	2.90518076
54	glycine metabolic process (GO:0006544)	2.89524494
55	establishment of mitochondrion localization (GO:0051654)	2.89391676
56	carnitine metabolic process (GO:0009437)	2.87866806
57	blood coagulation, intrinsic pathway (GO:0007597)	2.87609881
58	branched-chain amino acid catabolic process (GO:0009083)	2.85872368
59	neural tube formation (GO:0001841)	2.85016443
60	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82851283
61	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.82809261
62	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.82504650
63	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.82504650
64	reflex (GO:0060004)	2.76409786
65	ubiquinone biosynthetic process (GO:0006744)	2.75923156
66	ether lipid metabolic process (GO:0046485)	2.75121399
67	mitochondrial fusion (GO:0008053)	2.72772992
68	gluconeogenesis (GO:0006094)	2.72203253
69	growth hormone secretion (GO:0030252)	2.72118434
70	pyruvate metabolic process (GO:0006090)	2.70872746
71	intraciliary transport (GO:0042073)	2.70429822
72	gamma-aminobutyric acid transport (GO:0015812)	2.69818639
73	microtubule depolymerization (GO:0007019)	2.68965240
74	S-adenosylmethionine metabolic process (GO:0046500)	2.67771800
75	vitamin biosynthetic process (GO:0009110)	2.67263386
76	protein insertion into membrane (GO:0051205)	2.66936375
77	neuronal stem cell maintenance (GO:0097150)	2.66138663
78	regulation of mitochondrial fission (GO:0090140)	2.65219872
79	cellular biogenic amine biosynthetic process (GO:0042401)	2.63072317
80	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.61748066
81	polyamine metabolic process (GO:0006595)	2.61324715
82	sulfur amino acid biosynthetic process (GO:0000097)	2.58562783
83	GPI anchor biosynthetic process (GO:0006506)	2.56102900
84	glucose 6-phosphate metabolic process (GO:0051156)	2.55774185
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.55448261
86	L-phenylalanine metabolic process (GO:0006558)	2.55448261
87	bile acid biosynthetic process (GO:0006699)	2.52772176
88	forebrain neuron differentiation (GO:0021879)	2.50457033
89	snRNA processing (GO:0016180)	2.50436485
90	phenylpropanoid metabolic process (GO:0009698)	2.50125870
91	de novo posttranslational protein folding (GO:0051084)	2.48999440
92	purine ribonucleotide transport (GO:0015868)	2.48274217
93	steroid biosynthetic process (GO:0006694)	2.47907291
94	olfactory bulb development (GO:0021772)	2.46721278
95	cellular aldehyde metabolic process (GO:0006081)	2.46538443
96	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.44829516
97	response to vitamin E (GO:0033197)	2.43548969
98	cullin deneddylation (GO:0010388)	2.43496201
99	COPI coating of Golgi vesicle (GO:0048205)	2.43478766
100	Golgi transport vesicle coating (GO:0048200)	2.43478766

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.69319723
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.66859298
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.40897022
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.36826472
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03293071
6	DCP1A_22483619_ChIP-Seq_HELA_Human	2.90088257
7	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.80321856
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.79072565
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76854869
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67029215
11	GABP_19822575_ChIP-Seq_HepG2_Human	2.61132524
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.60577747
13	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.56172889
14	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.32209984
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30606085
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16503905
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12169535
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.08916711
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.06751630
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.05693662
21	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.04218056
22	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	2.02051028
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.02022078
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.00671267
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.96945878
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.94398083
27	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.93549607
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86982424
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.86082312
30	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.82032055
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.80010812
32	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.79841848
33	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.77557068
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74733755
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.72692856
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71661537
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70158555
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66244990
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.59799277
40	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.59387678
41	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.58898232
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58885563
43	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.52462647
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.52402952
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.51768715
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.51220719
47	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.47990107
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.44632054
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44246358
50	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.43749864
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.39490723
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.39078421
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34875302
54	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.32627230
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.31745447
56	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.28916542
57	KDM5A_27292631_Chip-Seq_BREAST_Human	1.25574797
58	EWS_26573619_Chip-Seq_HEK293_Human	1.24235973
59	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.23667487
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21379845
61	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.19027282
62	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.14379757
63	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.14099431
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13901857
65	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.12851372
66	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.11712276
67	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.11175281
68	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.10153847
69	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.06343548
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.05736739
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.03711135
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03002177
73	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.02011195
74	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00805619
75	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.00558652
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98802779
77	TFEB_21752829_ChIP-Seq_HELA_Human	0.98010593
78	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94965687
79	VDR_22108803_ChIP-Seq_LS180_Human	0.93805523
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93623397
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92813490
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92552642
83	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.91759441
84	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.91189917
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91150265
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90762999
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.88877046
88	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.88390112
89	AR_20517297_ChIP-Seq_VCAP_Human	0.88207289
90	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.87978379
91	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87627928
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.87449915
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86688063
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.86282331
95	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.86242534
96	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.85675050
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85588785
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.83704656
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.83041110
100	TP53_22573176_ChIP-Seq_HFKS_Human	0.82691977

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.89617824
2	MP0008789_abnormal_olfactory_epithelium	4.07504224
3	MP0001529_abnormal_vocalization	3.91397244
4	MP0005394_taste/olfaction_phenotype	3.81432302
5	MP0005499_abnormal_olfactory_system	3.81432302
6	MP0002653_abnormal_ependyma_morphology	3.48016702
7	MP0005248_abnormal_Harderian_gland	2.98192255
8	MP0005085_abnormal_gallbladder_physiolo	2.61298174
9	MP0001984_abnormal_olfaction	2.28798927
10	MP0003221_abnormal_cardiomyocyte_apopto	2.27386589
11	MP0005360_urolithiasis	2.23069492
12	MP0005187_abnormal_penis_morphology	2.15412085
13	MP0001764_abnormal_homeostasis	2.14231027
14	MP0002090_abnormal_vision	1.99832055
15	MP0003122_maternal_imprinting	1.95467486
16	MP0000579_abnormal_nail_morphology	1.86536245
17	MP0005451_abnormal_body_composition	1.81447557
18	MP0006054_spinal_hemorrhage	1.74818428
19	MP0006072_abnormal_retinal_apoptosis	1.71582638
20	MP0008932_abnormal_embryonic_tissue	1.66937803
21	MP0002282_abnormal_trachea_morphology	1.65432371
22	MP0003011_delayed_dark_adaptation	1.64144399
23	MP0006292_abnormal_olfactory_placode	1.60343946
24	MP0005623_abnormal_meninges_morphology	1.57457543
25	MP0002139_abnormal_hepatobiliary_system	1.51428006
26	MP0005646_abnormal_pituitary_gland	1.50551340
27	MP0005253_abnormal_eye_physiology	1.49713695
28	MP0006276_abnormal_autonomic_nervous	1.45190841
29	MP0003880_abnormal_central_pattern	1.45167039
30	MP0008995_early_reproductive_senescence	1.44691485
31	MP0008260_abnormal_autophagy	1.43839700
32	MP0008058_abnormal_DNA_repair	1.41179364
33	MP0005365_abnormal_bile_salt	1.36589578
34	MP0001727_abnormal_embryo_implantation	1.36496352
35	MP0000778_abnormal_nervous_system	1.35596192
36	MP0002234_abnormal_pharynx_morphology	1.30541191
37	MP0003868_abnormal_feces_composition	1.29750148
38	MP0006035_abnormal_mitochondrial_morpho	1.29253087
39	MP0004147_increased_porphyrin_level	1.27338842
40	MP0002736_abnormal_nociception_after	1.25210739
41	MP0000647_abnormal_sebaceous_gland	1.22879810
42	MP0003111_abnormal_nucleus_morphology	1.22289534
43	MP0004019_abnormal_vitamin_homeostasis	1.21949044
44	MP0000467_abnormal_esophagus_morphology	1.21640917
45	MP0001340_abnormal_eyelid_morphology	1.18935979
46	MP0010030_abnormal_orbit_morphology	1.18803251
47	MP0000358_abnormal_cell_content/	1.18538409
48	MP0003806_abnormal_nucleotide_metabolis	1.18373494
49	MP0002697_abnormal_eye_size	1.14114919
50	MP0005645_abnormal_hypothalamus_physiol	1.13257357
51	MP0005084_abnormal_gallbladder_morpholo	1.12586103
52	MP0010386_abnormal_urinary_bladder	1.11357754
53	MP0002138_abnormal_hepatobiliary_system	1.08370825
54	MP0004233_abnormal_muscle_weight	1.07397753
55	MP0005501_abnormal_skin_physiology	1.06272244
56	MP0001293_anophthalmia	1.05054742
57	MP0003693_abnormal_embryo_hatching	1.00446345
58	MP0002233_abnormal_nose_morphology	0.99375242
59	MP0004133_heterotaxia	0.98674930
60	MP0005647_abnormal_sex_gland	0.98244798
61	MP0005410_abnormal_fertilization	0.97904647
62	MP0003186_abnormal_redox_activity	0.96343415
63	MP0010368_abnormal_lymphatic_system	0.92655514
64	MP0003786_premature_aging	0.91984410
65	MP0005391_vision/eye_phenotype	0.90225728
66	MP0005167_abnormal_blood-brain_barrier	0.90090274
67	MP0005464_abnormal_platelet_physiology	0.89331018
68	MP0008875_abnormal_xenobiotic_pharmacok	0.89325527
69	MP0003937_abnormal_limbs/digits/tail_de	0.88083517
70	MP0010329_abnormal_lipoprotein_level	0.87352499
71	MP0000465_gastrointestinal_hemorrhage	0.87120725
72	MP0002751_abnormal_autonomic_nervous	0.86583063
73	MP0003698_abnormal_male_reproductive	0.80945247
74	MP0005195_abnormal_posterior_eye	0.78884747
75	MP0000049_abnormal_middle_ear	0.78836379
76	MP0001919_abnormal_reproductive_system	0.78302569
77	MP0008004_abnormal_stomach_pH	0.77967894
78	MP0003137_abnormal_impulse_conducting	0.77501244
79	MP0003077_abnormal_cell_cycle	0.77095658
80	MP0003567_abnormal_fetal_cardiomyocyte	0.76803405
81	MP0002928_abnormal_bile_duct	0.76509988
82	MP0000383_abnormal_hair_follicle	0.76095605
83	MP0009053_abnormal_anal_canal	0.74289568
84	MP0000631_abnormal_neuroendocrine_gland	0.72900705
85	MP0003252_abnormal_bile_duct	0.72486161
86	MP0008872_abnormal_physiological_respon	0.71539886
87	MP0001905_abnormal_dopamine_level	0.70162746
88	MP0002092_abnormal_eye_morphology	0.69478673
89	MP0002098_abnormal_vibrissa_morphology	0.68211041
90	MP0003121_genomic_imprinting	0.68174633
91	MP0001849_ear_inflammation	0.67607333
92	MP0001968_abnormal_touch/_nociception	0.64231534
93	MP0000026_abnormal_inner_ear	0.63660352
94	MP0004142_abnormal_muscle_tone	0.63248131
95	MP0009384_cardiac_valve_regurgitation	0.61982468
96	MP0002752_abnormal_somatic_nervous	0.61244576
97	MP0002572_abnormal_emotion/affect_behav	0.60955798
98	MP0004811_abnormal_neuron_physiology	0.59793679
99	MP0010678_abnormal_skin_adnexa	0.59293804
100	MP0004272_abnormal_basement_membrane	0.59101769

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	5.16481211
2	Neonatal respiratory distress (HP:0002643)	4.52673511
3	Hypoplastic pelvis (HP:0008839)	4.29893528
4	Cholecystitis (HP:0001082)	4.27378878
5	Abnormal gallbladder physiology (HP:0012438)	4.27378878
6	Thyroid-stimulating hormone excess (HP:0002925)	4.06745522
7	Congenital primary aphakia (HP:0007707)	3.66256978
8	Gait imbalance (HP:0002141)	3.64132422
9	Nephrogenic diabetes insipidus (HP:0009806)	3.58838425
10	Abnormality of serine family amino acid metabolism (HP:0010894)	3.54122034
11	Abnormality of glycine metabolism (HP:0010895)	3.54122034
12	Exercise-induced muscle cramps (HP:0003710)	3.48960934
13	Shoulder girdle muscle weakness (HP:0003547)	3.21357022
14	Medial flaring of the eyebrow (HP:0010747)	3.17844962
15	Abnormality of glycolysis (HP:0004366)	3.10189876
16	Abnormality of the musculature of the pelvis (HP:0001469)	3.10117903
17	Abnormality of the hip-girdle musculature (HP:0001445)	3.10117903
18	Retinal dysplasia (HP:0007973)	3.01236186
19	True hermaphroditism (HP:0010459)	2.97418820
20	Increased serum pyruvate (HP:0003542)	2.88154065
21	Poikiloderma (HP:0001029)	2.84988570
22	Hyperglycinuria (HP:0003108)	2.79954391
23	Abnormality of serum amino acid levels (HP:0003112)	2.78747680
24	Entropion (HP:0000621)	2.74569649
25	High anterior hairline (HP:0009890)	2.72497116
26	Pelvic girdle muscle weakness (HP:0003749)	2.70474948
27	Reduced antithrombin III activity (HP:0001976)	2.55095492
28	Generalized aminoaciduria (HP:0002909)	2.53682602
29	Termporal pattern (HP:0011008)	2.50989886
30	Insidious onset (HP:0003587)	2.50989886
31	Abnormal protein glycosylation (HP:0012346)	2.46958777
32	Abnormal glycosylation (HP:0012345)	2.46958777
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.46958777
34	Abnormal protein N-linked glycosylation (HP:0012347)	2.46958777
35	Broad foot (HP:0001769)	2.46141150
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.45260767
37	Occipital encephalocele (HP:0002085)	2.43202183
38	Abnormality of the metopic suture (HP:0005556)	2.42890334
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37409042
40	Cortical dysplasia (HP:0002539)	2.36076021
41	Pancreatic fibrosis (HP:0100732)	2.34515273
42	Decreased testicular size (HP:0008734)	2.34195108
43	Back pain (HP:0003418)	2.31633003
44	Vaginal atresia (HP:0000148)	2.28657568
45	Postaxial foot polydactyly (HP:0001830)	2.27720982
46	Failure to thrive in infancy (HP:0001531)	2.25711482
47	Chronic bronchitis (HP:0004469)	2.25624057
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25084245
49	Rimmed vacuoles (HP:0003805)	2.25059534
50	Genital tract atresia (HP:0001827)	2.22257618
51	Pancreatic cysts (HP:0001737)	2.22063233
52	Hyperammonemia (HP:0001987)	2.19804164
53	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.18932927
54	Postaxial hand polydactyly (HP:0001162)	2.18729756
55	Poor coordination (HP:0002370)	2.18480961
56	Abnormality of alanine metabolism (HP:0010916)	2.17738585
57	Hyperalaninemia (HP:0003348)	2.17738585
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17738585
59	Specific learning disability (HP:0001328)	2.17403452
60	Rhabdomyolysis (HP:0003201)	2.16085064
61	Abnormal ciliary motility (HP:0012262)	2.13115235
62	Methylmalonic acidemia (HP:0002912)	2.11679259
63	Microglossia (HP:0000171)	2.11203238
64	Abnormal gallbladder morphology (HP:0012437)	2.09726621
65	Cholelithiasis (HP:0001081)	2.08475090
66	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05754549
67	Abnormal respiratory epithelium morphology (HP:0012253)	2.05754549
68	Fragile nails (HP:0001808)	2.01802468
69	Adactyly (HP:0009776)	1.99742319
70	Abnormality of fatty-acid metabolism (HP:0004359)	1.99699358
71	Aplasia/Hypoplasia of the lens (HP:0008063)	1.95585592
72	Myoglobinuria (HP:0002913)	1.93316949
73	Epiphyseal stippling (HP:0010655)	1.93290095
74	Polyphagia (HP:0002591)	1.92503499
75	Reticulocytosis (HP:0001923)	1.91611176
76	Postnatal microcephaly (HP:0005484)	1.91287290
77	Degeneration of anterior horn cells (HP:0002398)	1.89359269
78	Abnormality of the anterior horn cell (HP:0006802)	1.89359269
79	Brushfield spots (HP:0001088)	1.87876858
80	Abnormality of the lower motor neuron (HP:0002366)	1.87274154
81	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.86719658
82	Methylmalonic aciduria (HP:0012120)	1.86021485
83	Bile duct proliferation (HP:0001408)	1.85698551
84	Abnormal biliary tract physiology (HP:0012439)	1.85698551
85	Prominent metopic ridge (HP:0005487)	1.83379518
86	Acute encephalopathy (HP:0006846)	1.81772940
87	Male infertility (HP:0003251)	1.81434833
88	Deep venous thrombosis (HP:0002625)	1.79193687
89	Cerebral edema (HP:0002181)	1.78097822
90	Sclerocornea (HP:0000647)	1.76871164
91	Proximal tubulopathy (HP:0000114)	1.76650948
92	Irregular epiphyses (HP:0010582)	1.74578735
93	Increased mean platelet volume (HP:0011877)	1.72784571
94	Abnormal lung lobation (HP:0002101)	1.71347599
95	Abnormality of the gallbladder (HP:0005264)	1.69139954
96	Central scotoma (HP:0000603)	1.66921542
97	Oligodactyly (HP:0012165)	1.65979558
98	Sensorimotor neuropathy (HP:0007141)	1.65066945
99	Adrenal hypoplasia (HP:0000835)	1.65052777
100	Lethargy (HP:0001254)	1.64557422

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SRPK1	5.54542341
2	BCR	4.22889299
3	STK16	4.11073799
4	BCKDK	3.57620348
5	RPS6KA4	2.58166815
6	CSNK1G3	2.51145416
7	MAP2K7	2.50853109
8	TRIM28	2.27922658
9	MAP3K4	2.27824114
10	CSNK1A1L	2.25703120
11	PIM2	2.20435345
12	WNK3	2.19153427
13	EPHA3	2.17177316
14	TESK2	1.95214574
15	CDK19	1.93554508
16	CSNK1G2	1.91728948
17	DYRK3	1.83053831
18	EPHB2	1.81421578
19	CSNK1G1	1.81406302
20	SIK3	1.77202207
21	TESK1	1.64447758
22	PAK6	1.60210935
23	NEK9	1.40950630
24	PLK2	1.38396139
25	DYRK2	1.37407767
26	MAP4K2	1.36694419
27	RAF1	1.31612947
28	FLT3	1.26103587
29	PBK	1.25622753
30	EPHA4	1.17515217
31	CASK	1.15461141
32	ERBB3	1.11966484
33	DYRK1B	1.08331435
34	MKNK1	1.06563536
35	PLK4	1.03879705
36	NEK1	1.03870756
37	LIMK1	1.01982526
38	PINK1	1.01148585
39	NEK2	0.98493878
40	CDK14	0.92165206
41	EPHB1	0.92159699
42	MARK1	0.89013458
43	MINK1	0.84720237
44	CCNB1	0.82753854
45	FER	0.81895370
46	TAOK3	0.81235648
47	AURKA	0.79470648
48	BUB1	0.79273241
49	PLK1	0.78227031
50	KSR1	0.76747796
51	TSSK6	0.75454944
52	MST4	0.74401671
53	CDK6	0.71681317
54	MAP3K5	0.70290556
55	PAK4	0.69474149
56	NUAK1	0.69013990
57	CAMK2G	0.67198760
58	KSR2	0.66767055
59	CDK18	0.60336893
60	AKT2	0.60303759
61	LMTK2	0.60207798
62	PAK3	0.59842488
63	MAP2K4	0.59445683
64	CDK11A	0.58809665
65	PDK2	0.54508187
66	CSNK1A1	0.50751604
67	CDK15	0.49877887
68	RPS6KA5	0.48884870
69	CAMK2D	0.46339870
70	CDC7	0.45829985
71	ARAF	0.45071044
72	EPHA2	0.42998255
73	PAK1	0.42687483
74	GRK7	0.41500541
75	CDK8	0.41424669
76	ATR	0.40733399
77	CAMK2B	0.39947599
78	AURKB	0.39309366
79	MUSK	0.38734471
80	CSNK2A1	0.38470940
81	PRKCG	0.36582277
82	PTK2B	0.36537852
83	PRKCE	0.36150031
84	BMX	0.35604709
85	CSNK1D	0.35337705
86	IRAK3	0.34801610
87	ROCK2	0.33780797
88	VRK1	0.31895680
89	VRK2	0.31267567
90	PLK3	0.30983346
91	IRAK1	0.30822219
92	DAPK1	0.30629748
93	DYRK1A	0.30316983
94	CDK3	0.30131132
95	MATK	0.28837009
96	UHMK1	0.28774873
97	CAMK2A	0.26468021
98	PRKACG	0.26261928
99	CDK7	0.25833291
100	MAPK9	0.25392476

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	4.35285351
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.45400133
3	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.22821244
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.12520456
5	Fatty acid elongation_Homo sapiens_hsa00062	2.65385526
6	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.47622567
7	Sulfur relay system_Homo sapiens_hsa04122	2.47362227
8	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.41506970
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.36164221
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.29126081
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22299021
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.19868729
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00064270
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.96987204
15	Protein export_Homo sapiens_hsa03060	1.88129496
16	Carbon metabolism_Homo sapiens_hsa01200	1.85088985
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83304622
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.80833786
19	Propanoate metabolism_Homo sapiens_hsa00640	1.75448660
20	Peroxisome_Homo sapiens_hsa04146	1.69626037
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61164423
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.54119589
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53442137
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.46319045
25	Base excision repair_Homo sapiens_hsa03410	1.46011946
26	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45075135
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.40514977
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.37794418
29	Butanoate metabolism_Homo sapiens_hsa00650	1.36492733
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36241651
31	Mismatch repair_Homo sapiens_hsa03430	1.29092076
32	Fatty acid degradation_Homo sapiens_hsa00071	1.28571206
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.24421362
34	DNA replication_Homo sapiens_hsa03030	1.24382933
35	Sulfur metabolism_Homo sapiens_hsa00920	1.19523150
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.16872126
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.08686079
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01810293
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01698010
40	Parkinsons disease_Homo sapiens_hsa05012	0.96182453
41	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.95209451
42	Pentose phosphate pathway_Homo sapiens_hsa00030	0.94138884
43	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.93744414
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93717542
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91219078
46	Retinol metabolism_Homo sapiens_hsa00830	0.87815244
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85974596
48	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.84284674
49	Metabolic pathways_Homo sapiens_hsa01100	0.81868237
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79827409
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.79714147
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78391932
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.78084342
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.77551816
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76472762
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75488297
57	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.74358369
58	RNA transport_Homo sapiens_hsa03013	0.73269491
59	Spliceosome_Homo sapiens_hsa03040	0.72813886
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.72338360
61	Regulation of autophagy_Homo sapiens_hsa04140	0.69567871
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.68473931
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67253184
64	RNA polymerase_Homo sapiens_hsa03020	0.66067915
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63116884
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60810722
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.60540485
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.59979921
69	Complement and coagulation cascades_Homo sapiens_hsa04610	0.59737479
70	Cell cycle_Homo sapiens_hsa04110	0.58234293
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56658361
72	Basal transcription factors_Homo sapiens_hsa03022	0.55027058
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53239435
74	Huntingtons disease_Homo sapiens_hsa05016	0.52029207
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51454684
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.51074324
77	Proteasome_Homo sapiens_hsa03050	0.50974469
78	PPAR signaling pathway_Homo sapiens_hsa03320	0.50194600
79	Bile secretion_Homo sapiens_hsa04976	0.50015679
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.49909362
81	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.48887502
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47304283
83	Folate biosynthesis_Homo sapiens_hsa00790	0.47088417
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46978026
85	Shigellosis_Homo sapiens_hsa05131	0.46521555
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.41948820
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.41935953
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41167049
89	Histidine metabolism_Homo sapiens_hsa00340	0.41066141
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40325863
91	Glutathione metabolism_Homo sapiens_hsa00480	0.39668982
92	Purine metabolism_Homo sapiens_hsa00230	0.39312379
93	One carbon pool by folate_Homo sapiens_hsa00670	0.38873841
94	Homologous recombination_Homo sapiens_hsa03440	0.38633418
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38632710
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37191502
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34837309
98	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33652857
99	GABAergic synapse_Homo sapiens_hsa04727	0.33220440
100	Oocyte meiosis_Homo sapiens_hsa04114	0.31672989

HDGFP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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