HDHD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84867771
2L-phenylalanine catabolic process (GO:0006559)6.84867771
3L-phenylalanine metabolic process (GO:0006558)6.51027340
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51027340
5epoxygenase P450 pathway (GO:0019373)5.98839732
6aromatic amino acid family catabolic process (GO:0009074)5.76994199
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.54554339
8glyoxylate metabolic process (GO:0046487)5.26481930
9bile acid biosynthetic process (GO:0006699)5.09659184
10sulfur amino acid catabolic process (GO:0000098)4.95264751
11indole-containing compound catabolic process (GO:0042436)4.86460103
12indolalkylamine catabolic process (GO:0046218)4.86460103
13tryptophan catabolic process (GO:0006569)4.86460103
14cysteine metabolic process (GO:0006534)4.75458134
15cellular ketone body metabolic process (GO:0046950)4.75317250
16kynurenine metabolic process (GO:0070189)4.71273582
17high-density lipoprotein particle remodeling (GO:0034375)4.69926400
18urea metabolic process (GO:0019627)4.63136937
19urea cycle (GO:0000050)4.63136937
20tryptophan metabolic process (GO:0006568)4.55945052
21intestinal absorption (GO:0050892)4.49719233
22regulation of triglyceride catabolic process (GO:0010896)4.46600929
23alpha-linolenic acid metabolic process (GO:0036109)4.44974775
24negative regulation of fibrinolysis (GO:0051918)4.40293825
25regulation of cholesterol esterification (GO:0010872)4.39510408
26NADH metabolic process (GO:0006734)4.37929895
27complement activation, alternative pathway (GO:0006957)4.37282986
28regulation of fibrinolysis (GO:0051917)4.34754801
29bile acid metabolic process (GO:0008206)4.32093246
30fat-soluble vitamin biosynthetic process (GO:0042362)4.31979976
31nitrogen cycle metabolic process (GO:0071941)4.30622814
32regulation of protein activation cascade (GO:2000257)4.28001520
33aromatic amino acid family metabolic process (GO:0009072)4.19311786
34serine family amino acid catabolic process (GO:0009071)4.18845384
35protein-lipid complex remodeling (GO:0034368)4.16268226
36macromolecular complex remodeling (GO:0034367)4.16268226
37plasma lipoprotein particle remodeling (GO:0034369)4.16268226
38protein carboxylation (GO:0018214)4.14592513
39peptidyl-glutamic acid carboxylation (GO:0017187)4.14592513
40reverse cholesterol transport (GO:0043691)4.12488479
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.10586491
42ketone body metabolic process (GO:1902224)4.10577709
43angiotensin maturation (GO:0002003)4.08873446
44coenzyme catabolic process (GO:0009109)4.08273277
45phenylpropanoid metabolic process (GO:0009698)4.05579060
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05042746
47tyrosine metabolic process (GO:0006570)4.02641351
48regulation of complement activation (GO:0030449)4.01039461
49alpha-amino acid catabolic process (GO:1901606)4.00907089
50negative regulation of sterol transport (GO:0032372)3.98572130
51negative regulation of cholesterol transport (GO:0032375)3.98572130
52acylglycerol homeostasis (GO:0055090)3.98488096
53triglyceride homeostasis (GO:0070328)3.98488096
54glutamate metabolic process (GO:0006536)3.94201078
55short-chain fatty acid metabolic process (GO:0046459)3.93281458
56alkaloid metabolic process (GO:0009820)3.89294945
57plasma lipoprotein particle clearance (GO:0034381)3.86218521
58cellular glucuronidation (GO:0052695)3.86005447
59flavonoid metabolic process (GO:0009812)3.84961854
60homocysteine metabolic process (GO:0050667)3.84757171
61bile acid and bile salt transport (GO:0015721)3.83594490
62phospholipid efflux (GO:0033700)3.82659933
63drug catabolic process (GO:0042737)3.82237428
64cellular amino acid catabolic process (GO:0009063)3.81238488
65ethanol metabolic process (GO:0006067)3.80426981
66lysine metabolic process (GO:0006553)3.80133194
67lysine catabolic process (GO:0006554)3.80133194
68amino-acid betaine metabolic process (GO:0006577)3.74872235
69positive regulation of triglyceride lipase activity (GO:0061365)3.73266778
70positive regulation of lipoprotein lipase activity (GO:0051006)3.73266778
71ethanol oxidation (GO:0006069)3.68798311
72fatty acid elongation (GO:0030497)3.68061884
73regulation of bile acid biosynthetic process (GO:0070857)3.65570233
74aldehyde catabolic process (GO:0046185)3.64052004
75cholesterol efflux (GO:0033344)3.62966138
76arginine metabolic process (GO:0006525)3.62666671
77cofactor catabolic process (GO:0051187)3.58896007
78cellular modified amino acid catabolic process (GO:0042219)3.58429515
79hormone catabolic process (GO:0042447)3.57240271
80positive regulation of triglyceride metabolic process (GO:0090208)3.56624846
81uronic acid metabolic process (GO:0006063)3.55981124
82glucuronate metabolic process (GO:0019585)3.55981124
83positive regulation of lipid catabolic process (GO:0050996)3.54508286
84acetyl-CoA metabolic process (GO:0006084)3.54277788
85very long-chain fatty acid metabolic process (GO:0000038)3.53000418
86serine family amino acid metabolic process (GO:0009069)3.51611368
87vitamin biosynthetic process (GO:0009110)3.49733001
88indolalkylamine metabolic process (GO:0006586)3.49072830
89proline metabolic process (GO:0006560)3.45401011
90carboxylic acid catabolic process (GO:0046395)3.42988261
91organic acid catabolic process (GO:0016054)3.42988261
92regulation of guanylate cyclase activity (GO:0031282)3.42310282
93low-density lipoprotein particle remodeling (GO:0034374)3.41807072
94amine catabolic process (GO:0009310)3.41051768
95cellular biogenic amine catabolic process (GO:0042402)3.41051768
96aspartate family amino acid catabolic process (GO:0009068)3.39419386
97cholesterol homeostasis (GO:0042632)3.39267892
98serine family amino acid biosynthetic process (GO:0009070)3.38865813
99omega-hydroxylase P450 pathway (GO:0097267)3.37349465
100GDP-mannose metabolic process (GO:0019673)3.37131533
101intestinal cholesterol absorption (GO:0030299)3.36305249
102drug transmembrane transport (GO:0006855)3.35054296
103monocarboxylic acid catabolic process (GO:0072329)3.33557405
104benzene-containing compound metabolic process (GO:0042537)3.33324444
105sterol homeostasis (GO:0055092)3.33293050
106exogenous drug catabolic process (GO:0042738)3.31505748
107fatty acid catabolic process (GO:0009062)3.31277079
108heme transport (GO:0015886)3.30351671
109diacylglycerol metabolic process (GO:0046339)3.29960482
110negative regulation of lipase activity (GO:0060192)3.29227482
111plasma lipoprotein particle assembly (GO:0034377)3.29083935
112L-ascorbic acid metabolic process (GO:0019852)3.27634712
113fatty acid oxidation (GO:0019395)3.26791885
114very-low-density lipoprotein particle assembly (GO:0034379)3.26561380
115fatty acid beta-oxidation (GO:0006635)3.26171639
116fibrinolysis (GO:0042730)3.23487272
117protein-lipid complex assembly (GO:0065005)3.23478247
118glycine metabolic process (GO:0006544)3.23403790
119lipid oxidation (GO:0034440)3.21136016
120fructose metabolic process (GO:0006000)3.20448986
121imidazole-containing compound metabolic process (GO:0052803)3.20338818
122drug metabolic process (GO:0017144)3.20063295
123polyketide metabolic process (GO:0030638)3.17645535
124doxorubicin metabolic process (GO:0044598)3.17645535
125daunorubicin metabolic process (GO:0044597)3.17645535
126glucocorticoid biosynthetic process (GO:0006704)3.17352328
127complement activation, classical pathway (GO:0006958)3.14715556
128drug transport (GO:0015893)3.11889461
129primary alcohol catabolic process (GO:0034310)3.11319248
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.11210009
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.11210009
132glutamine family amino acid biosynthetic process (GO:0009084)3.01222988
133proline biosynthetic process (GO:0006561)3.00363078
134positive regulation of icosanoid secretion (GO:0032305)2.96437924
135plasma lipoprotein particle organization (GO:0071827)2.91169474
136xenobiotic metabolic process (GO:0006805)2.89309262
137regulation of systemic arterial blood pressure by hormone (GO:0001990)2.89190389
138regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.89190389
139endocrine process (GO:0050886)2.89190389
140arginine catabolic process (GO:0006527)2.88552474
141lipoprotein transport (GO:0042953)2.88533573
142positive regulation of fatty acid biosynthetic process (GO:0045723)2.88241792
143glutathione biosynthetic process (GO:0006750)2.87665240
144quinone biosynthetic process (GO:1901663)2.86138086
145regulation of triglyceride metabolic process (GO:0090207)2.82816480
146oxidative demethylation (GO:0070989)2.82605125
147protein activation cascade (GO:0072376)2.81274668
148amyloid precursor protein catabolic process (GO:0042987)2.80322382
149positive regulation of fatty acid transport (GO:2000193)2.79821582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.45795832
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.46124061
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.53799797
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.53314111
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.13250934
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.55201277
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.02620986
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01914000
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.95790982
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.97162985
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90417363
12LXR_22292898_ChIP-Seq_THP-1_Human2.43655361
13* TET1_21451524_ChIP-Seq_MESCs_Mouse2.20415076
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03110405
15RACK7_27058665_Chip-Seq_MCF-7_Human1.91742679
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.86745949
17* BCL6_27268052_Chip-Seq_Bcells_Human1.85520936
18HTT_18923047_ChIP-ChIP_STHdh_Human1.84809364
19P68_20966046_ChIP-Seq_HELA_Human1.82218506
20BCOR_27268052_Chip-Seq_Bcells_Human1.75825264
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69924373
22GATA6_25053715_ChIP-Seq_YYC3_Human1.65691291
23VDR_21846776_ChIP-Seq_THP-1_Human1.62055443
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61522257
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59657764
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59253053
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58005822
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56473106
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51851727
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51334237
31PHF8_20622854_ChIP-Seq_HELA_Human1.48739029
32E2F1_20622854_ChIP-Seq_HELA_Human1.48443733
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.47922261
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46677018
35CTCF_20526341_ChIP-Seq_ESCs_Human1.43395141
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42630398
37SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.42553131
38* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41735108
39SA1_27219007_Chip-Seq_Bcells_Human1.40119669
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40047637
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35571302
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.35125671
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.34567584
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.34540951
45GBX2_23144817_ChIP-Seq_PC3_Human1.32383343
46TAF15_26573619_Chip-Seq_HEK293_Human1.32081048
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31854727
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.30929063
49RARA_24833708_ChIP-Seq_LIVER_Mouse1.25929230
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23858135
51CTCF_26484167_Chip-Seq_Bcells_Mouse1.22744394
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.22547769
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21932220
54P300_27268052_Chip-Seq_Bcells_Human1.21634493
55SMC4_20622854_ChIP-Seq_HELA_Human1.20982390
56CTCF_21964334_Chip-Seq_Bcells_Human1.20401186
57RARB_24833708_ChIP-Seq_LIVER_Mouse1.19866119
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19121924
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18619031
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17431323
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17209069
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15015554
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14267173
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.13055830
65* ETS1_21867929_ChIP-Seq_TH2_Mouse1.12790718
66CLOCK_20551151_ChIP-Seq_293T_Human1.11125438
67* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11034351
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10304567
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10089241
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09786595
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09654412
72CREB1_26743006_Chip-Seq_LNCaP_Human1.08626068
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08524107
74* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08234745
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08061460
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07358990
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06580691
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06580691
79LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05120519
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05087363
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04614931
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04207871
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02788326
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02581822
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02347232
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.02274614
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.01921179
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01882511
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01028800
90TP63_22573176_ChIP-Seq_HFKS_Human1.00894233
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99930838
92* ERA_21632823_ChIP-Seq_H3396_Human0.99744212
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99170853
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99023371
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.98010428
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97489913
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96889479
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96744534
99RAC3_21632823_ChIP-Seq_H3396_Human0.96354696
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95794324
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95719518
102VDR_22108803_ChIP-Seq_LS180_Human0.93442501
103MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93137077
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92590456
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.92515188
106EED_16625203_ChIP-ChIP_MESCs_Mouse0.92502776
107GATA3_21867929_ChIP-Seq_CD8_Mouse0.92444425
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92204307
109SOX2_20726797_ChIP-Seq_SW620_Human0.91974753
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90313699
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89307429
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87886944
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86929003
114GATA4_25053715_ChIP-Seq_YYC3_Human0.86726858
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85296551
116SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84657677
117ZNF263_19887448_ChIP-Seq_K562_Human0.82476318
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82051767
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81892635
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80551924
121BCAT_22108803_ChIP-Seq_LS180_Human0.80271368
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80156567
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.79246143
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.78918677
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78736232
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78531995
127AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78446808
128MYC_19915707_ChIP-ChIP_AK7_Human0.75938838
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75840074
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74296043
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73669802
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73669802
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72987644
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72418562
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.71154267
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71054132
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.70410141
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69857938
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69763216
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68536354
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68066759
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65583580
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65423279
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63354838
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.63342033
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62557974
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.62302383
148SUZ12_27294783_Chip-Seq_ESCs_Mouse0.62148140
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61977408
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59717411
151P300_19829295_ChIP-Seq_ESCs_Human0.59039890
152CTCF_27219007_Chip-Seq_Bcells_Human0.59029217
153NCOR_22424771_ChIP-Seq_293T_Human0.58927682
154AR_20517297_ChIP-Seq_VCAP_Human0.58862828
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58487585
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.58080972
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.57856001
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57320577
159CBP_21632823_ChIP-Seq_H3396_Human0.56652287
160AR_21572438_ChIP-Seq_LNCaP_Human0.56521964
161ERG_20517297_ChIP-Seq_VCAP_Human0.55815117
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.55718546
163TAF2_19829295_ChIP-Seq_ESCs_Human0.55433905
164NANOG_19829295_ChIP-Seq_ESCs_Human0.55399570
165SOX2_19829295_ChIP-Seq_ESCs_Human0.55399570
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.55302218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.60083924
2MP0005360_urolithiasis7.38857742
3MP0005085_abnormal_gallbladder_physiolo5.65080589
4MP0005365_abnormal_bile_salt5.16797321
5MP0008875_abnormal_xenobiotic_pharmacok4.73124316
6MP0003806_abnormal_nucleotide_metabolis4.19427573
7MP0003252_abnormal_bile_duct3.39730131
8MP0010329_abnormal_lipoprotein_level3.18654907
9MP0001666_abnormal_nutrient_absorption2.86675371
10MP0005332_abnormal_amino_acid2.78656440
11MP0009840_abnormal_foam_cell2.74780458
12MP0005083_abnormal_biliary_tract2.73499986
13MP0003195_calcinosis2.66201869
14MP0000678_abnormal_parathyroid_gland2.34754426
15MP0004019_abnormal_vitamin_homeostasis2.18795883
16MP0002118_abnormal_lipid_homeostasis1.98898945
17MP0005670_abnormal_white_adipose1.94826957
18MP0003191_abnormal_cellular_cholesterol1.91114260
19MP0003183_abnormal_peptide_metabolism1.82220420
20MP0004264_abnormal_extraembryonic_tissu1.79040638
21MP0010234_abnormal_vibrissa_follicle1.76504124
22MP0003868_abnormal_feces_composition1.72516949
23MP0001764_abnormal_homeostasis1.70349906
24MP0000609_abnormal_liver_physiology1.62096828
25MP0005451_abnormal_body_composition1.61588452
26MP0003011_delayed_dark_adaptation1.61191329
27MP0010155_abnormal_intestine_physiology1.56160217
28MP0002138_abnormal_hepatobiliary_system1.55775368
29MP0005584_abnormal_enzyme/coenzyme_acti1.53643994
30MP0003329_amyloid_beta_deposits1.49095198
31MP0005319_abnormal_enzyme/_coenzyme1.47389493
32MP0003866_abnormal_defecation1.46476041
33MP0001873_stomach_inflammation1.43514504
34MP0005058_abnormal_lysosome_morphology1.39311530
35MP0002876_abnormal_thyroid_physiology1.37414608
36MP0000604_amyloidosis1.31501347
37MP0009697_abnormal_copulation1.29944328
38MP0002837_dystrophic_cardiac_calcinosis1.25047305
39MP0009643_abnormal_urine_homeostasis1.24895655
40MP0005084_abnormal_gallbladder_morpholo1.24326503
41MP0009333_abnormal_splenocyte_physiolog1.18480537
42MP0002822_catalepsy1.17571835
43MP0005636_abnormal_mineral_homeostasis1.14255515
44MP0002132_abnormal_respiratory_system1.10502605
45MP0000490_abnormal_crypts_of1.10312188
46MP0000477_abnormal_intestine_morphology1.09853995
47MP0000537_abnormal_urethra_morphology1.09035100
48MP0006036_abnormal_mitochondrial_physio1.01630775
49MP0002136_abnormal_kidney_physiology1.00938333
50MP0003646_muscle_fatigue1.00690826
51MP0003186_abnormal_redox_activity0.99981385
52MP0002249_abnormal_larynx_morphology0.99025529
53MP0001663_abnormal_digestive_system0.96104939
54MP0000681_abnormal_thyroid_gland0.94917662
55MP0004043_abnormal_pH_regulation0.93189464
56MP0009379_abnormal_foot_pigmentation0.92011935
57MP0003690_abnormal_glial_cell0.89974761
58MP0005166_decreased_susceptibility_to0.89568129
59MP0005376_homeostasis/metabolism_phenot0.88966667
60MP0004782_abnormal_surfactant_physiolog0.88245983
61MP0003656_abnormal_erythrocyte_physiolo0.88126462
62MP0001485_abnormal_pinna_reflex0.87506262
63MP0003436_decreased_susceptibility_to0.87497168
64MP0005535_abnormal_body_temperature0.85733914
65MP0000462_abnormal_digestive_system0.85316294
66MP0005408_hypopigmentation0.84594647
67MP0000920_abnormal_myelination0.83073548
68MP0002254_reproductive_system_inflammat0.81200331
69MP0001661_extended_life_span0.80900720
70MP0005647_abnormal_sex_gland0.80121747
71MP0002653_abnormal_ependyma_morphology0.79081237
72MP0005448_abnormal_energy_balance0.78846115
73MP0002089_abnormal_postnatal_growth/wei0.78109108
74MP0004142_abnormal_muscle_tone0.77706458
75MP0001440_abnormal_grooming_behavior0.77301902
76MP0004147_increased_porphyrin_level0.76166141
77MP0002098_abnormal_vibrissa_morphology0.76067203
78MP0009642_abnormal_blood_homeostasis0.76034418
79MP0001529_abnormal_vocalization0.73912602
80MP0002078_abnormal_glucose_homeostasis0.72936587
81MP0000598_abnormal_liver_morphology0.72916664
82MP0005266_abnormal_metabolism0.69928077
83MP0005551_abnormal_eye_electrophysiolog0.69292216
84MP0002971_abnormal_brown_adipose0.69065588
85MP0001845_abnormal_inflammatory_respons0.68887895
86MP0004858_abnormal_nervous_system0.68749409
87MP0003693_abnormal_embryo_hatching0.68127205
88MP0006035_abnormal_mitochondrial_morpho0.67402662
89MP0003283_abnormal_digestive_organ0.67379825
90MP0004270_analgesia0.65892511
91MP0001664_abnormal_digestion0.65299740
92MP0000467_abnormal_esophagus_morphology0.63629157
93MP0003718_maternal_effect0.62926777
94MP0005646_abnormal_pituitary_gland0.62922638
95MP0009763_increased_sensitivity_to0.62408968
96MP0001727_abnormal_embryo_implantation0.61991804
97MP0002736_abnormal_nociception_after0.61536350
98MP0005025_abnormal_response_to0.60588901
99MP0009785_altered_susceptibility_to0.60091938
100MP0006276_abnormal_autonomic_nervous0.59905636
101MP0009765_abnormal_xenobiotic_induced0.58124845
102MP0002277_abnormal_respiratory_mucosa0.57991290
103MP0001765_abnormal_ion_homeostasis0.57922423
104MP0008872_abnormal_physiological_respon0.57612177
105MP0008469_abnormal_protein_level0.57441500
106MP0004185_abnormal_adipocyte_glucose0.56920754
107MP0002160_abnormal_reproductive_system0.56394160
108MP0002796_impaired_skin_barrier0.56321259
109MP0003638_abnormal_response/metabolism_0.55906335
110MP0005501_abnormal_skin_physiology0.55791791
111MP0003724_increased_susceptibility_to0.55320206
112MP0009384_cardiac_valve_regurgitation0.55308053
113MP0001501_abnormal_sleep_pattern0.54860493
114MP0001881_abnormal_mammary_gland0.54854741
115MP0002272_abnormal_nervous_system0.54347056
116MP0008260_abnormal_autophagy0.54096010
117MP0005334_abnormal_fat_pad0.53609868
118MP0002909_abnormal_adrenal_gland0.53198675
119MP0001905_abnormal_dopamine_level0.52782833
120MP0004130_abnormal_muscle_cell0.52377904
121MP0000230_abnormal_systemic_arterial0.51915395
122MP0008004_abnormal_stomach_pH0.51867217
123MP0000639_abnormal_adrenal_gland0.51537851
124MP0009764_decreased_sensitivity_to0.50858350
125MP0001756_abnormal_urination0.50613240
126MP0002090_abnormal_vision0.50436040
127MP0003880_abnormal_central_pattern0.49856470
128MP0005220_abnormal_exocrine_pancreas0.47642444
129MP0002229_neurodegeneration0.46515791
130MP0009745_abnormal_behavioral_response0.45816391
131MP0000538_abnormal_urinary_bladder0.44609659
132MP0003953_abnormal_hormone_level0.44155099
133MP0008874_decreased_physiological_sensi0.43985333
134MP0005395_other_phenotype0.43638962
135MP0002064_seizures0.42256146
136MP0002295_abnormal_pulmonary_circulatio0.41591167
137MP0005595_abnormal_vascular_smooth0.41561369
138MP0005381_digestive/alimentary_phenotyp0.41469717
139MP0005666_abnormal_adipose_tissue0.39987326
140MP0001968_abnormal_touch/_nociception0.39926748
141MP0003879_abnormal_hair_cell0.39617382
142MP0004381_abnormal_hair_follicle0.38537824
143MP0000579_abnormal_nail_morphology0.38514137

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.51738049
2Intrahepatic cholestasis (HP:0001406)6.16927710
3Deep venous thrombosis (HP:0002625)5.80208840
4Hypobetalipoproteinemia (HP:0003563)5.41090933
5Xanthomatosis (HP:0000991)5.33246148
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.17216755
7Prolonged partial thromboplastin time (HP:0003645)5.16468622
8Hyperlipoproteinemia (HP:0010980)4.76986636
9Systemic lupus erythematosus (HP:0002725)4.47736700
10Hyperammonemia (HP:0001987)4.06333453
11Complement deficiency (HP:0004431)4.01605104
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.00793446
13Hyperglycinemia (HP:0002154)3.85806519
14Abnormality of serine family amino acid metabolism (HP:0010894)3.84359177
15Abnormality of glycine metabolism (HP:0010895)3.84359177
16Hypolipoproteinemia (HP:0010981)3.82971725
17Ketosis (HP:0001946)3.82395942
18Conjugated hyperbilirubinemia (HP:0002908)3.76461269
19Fat malabsorption (HP:0002630)3.74964689
20Hyperglycinuria (HP:0003108)3.73822800
21Cerebral edema (HP:0002181)3.61320026
22Cerebral palsy (HP:0100021)3.60402605
23Hypoglycemic coma (HP:0001325)3.58621732
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.58372520
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50271368
26Epidermoid cyst (HP:0200040)3.37225154
27Acute encephalopathy (HP:0006846)3.32898447
28Abnormality of the common coagulation pathway (HP:0010990)3.28989871
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.27170619
30Joint hemorrhage (HP:0005261)3.27017011
31Abnormality of fatty-acid metabolism (HP:0004359)3.19361480
32Abnormality of methionine metabolism (HP:0010901)3.16864553
33Decreased circulating renin level (HP:0003351)3.14685298
34Lethargy (HP:0001254)3.08843897
35Hypoalphalipoproteinemia (HP:0003233)3.05804835
36Ketoacidosis (HP:0001993)3.02126258
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.01559655
38Delayed CNS myelination (HP:0002188)2.95812957
39Spontaneous abortion (HP:0005268)2.92833243
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91365182
41Dicarboxylic aciduria (HP:0003215)2.91365182
42Hypercholesterolemia (HP:0003124)2.86719083
43Hyperbilirubinemia (HP:0002904)2.84799692
44Hepatic necrosis (HP:0002605)2.82801728
45Acute necrotizing encephalopathy (HP:0006965)2.78460649
46Metabolic acidosis (HP:0001942)2.77363412
47Steatorrhea (HP:0002570)2.73154485
48Vascular calcification (HP:0004934)2.72210504
49Abnormality of the intrinsic pathway (HP:0010989)2.71980845
50Abnormality of complement system (HP:0005339)2.71779331
51Abnormal mitochondria in muscle tissue (HP:0008316)2.70709465
52Glomerulonephritis (HP:0000099)2.70015467
53Hypoplasia of the uterus (HP:0000013)2.64018696
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.63494435
55Abnormality of serum amino acid levels (HP:0003112)2.62137846
56Abnormal gallbladder physiology (HP:0012438)2.58366535
57Cholecystitis (HP:0001082)2.58366535
58Abnormality of vitamin B metabolism (HP:0004340)2.57038982
59Abnormality of urine glucose concentration (HP:0011016)2.55487349
60Glycosuria (HP:0003076)2.55487349
61Hepatocellular necrosis (HP:0001404)2.53510622
62Abnormality of glycolysis (HP:0004366)2.47465625
63Increased serum pyruvate (HP:0003542)2.47465625
64Mitochondrial inheritance (HP:0001427)2.47397458
65Abnormal urine phosphate concentration (HP:0012599)2.47172274
66Hyperactive renin-angiotensin system (HP:0000841)2.45384675
67Vomiting (HP:0002013)2.45183855
68Gout (HP:0001997)2.42272170
69Abnormal gallbladder morphology (HP:0012437)2.41457635
70Cardiovascular calcification (HP:0011915)2.40631082
71Increased purine levels (HP:0004368)2.38489778
72Hyperuricemia (HP:0002149)2.38489778
73Hypophosphatemia (HP:0002148)2.36901149
74Hyperventilation (HP:0002883)2.36600213
75Malnutrition (HP:0004395)2.36102700
76Abnormality of purine metabolism (HP:0004352)2.35590062
77Abnormality of nucleobase metabolism (HP:0010932)2.34747825
78Acanthocytosis (HP:0001927)2.34106784
79Abnormality of pyrimidine metabolism (HP:0004353)2.33063351
80Progressive macrocephaly (HP:0004481)2.32444670
81Villous atrophy (HP:0011473)2.31776757
82Abnormality of small intestinal villus morphology (HP:0011472)2.31776757
83Cholelithiasis (HP:0001081)2.30957715
84Skin nodule (HP:0200036)2.29097929
85Hemorrhage of the eye (HP:0011885)2.28812272
86Nausea (HP:0002018)2.26200187
87Irritability (HP:0000737)2.24979685
88Increased muscle lipid content (HP:0009058)2.24437469
89Lipid accumulation in hepatocytes (HP:0006561)2.24231635
90Hypoglycemic seizures (HP:0002173)2.24078748
91Congenital sensorineural hearing impairment (HP:0008527)2.23007438
92Renal Fanconi syndrome (HP:0001994)2.22202507
93Spastic paraparesis (HP:0002313)2.21625753
94Abnormality of renin-angiotensin system (HP:0000847)2.21077817
95Brushfield spots (HP:0001088)2.20542655
96Abdominal distention (HP:0003270)2.20174669
97Pigmentary retinal degeneration (HP:0001146)2.18952705
98Ileus (HP:0002595)2.18436964
99Osteomalacia (HP:0002749)2.15695230
100Increased CSF lactate (HP:0002490)2.15634259
101Rickets (HP:0002748)2.12908062
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11622352
103Increased intramyocellular lipid droplets (HP:0012240)2.11111837
104Generalized aminoaciduria (HP:0002909)2.09798608
105Amyloidosis (HP:0011034)2.08919488
106Hepatocellular carcinoma (HP:0001402)2.08460697
107Sensorimotor neuropathy (HP:0007141)2.08370454
108Confusion (HP:0001289)2.08017254
109Hydroxyprolinuria (HP:0003080)2.07925108
110Abnormality of proline metabolism (HP:0010907)2.07925108
111Abnormality of vitamin metabolism (HP:0100508)2.07641574
112Lactic acidosis (HP:0003128)2.07419446
113Nephrolithiasis (HP:0000787)2.03525848
114Metabolic alkalosis (HP:0200114)2.03504072
115Alkalosis (HP:0001948)2.02644553
116Neonatal onset (HP:0003623)2.02034841
117Abnormality of the gallbladder (HP:0005264)2.00858540
118Late onset (HP:0003584)1.99292315
119Hyperphosphaturia (HP:0003109)1.98353784
120Neurofibrillary tangles (HP:0002185)1.96218229
121Abnormal enzyme/coenzyme activity (HP:0012379)1.94834365
122Pancreatitis (HP:0001733)1.94160462
123Hyperinsulinemic hypoglycemia (HP:0000825)1.93920652
124Abnormality of alkaline phosphatase activity (HP:0004379)1.92781157
125Widely patent fontanelles and sutures (HP:0004492)1.92672053
126Aplasia/hypoplasia of the uterus (HP:0008684)1.92508751
127Opisthotonus (HP:0002179)1.91799960
128Abnormal tarsal ossification (HP:0008369)1.91653837
129Abnormality of the costochondral junction (HP:0000919)1.91562569
130Methylmalonic aciduria (HP:0012120)1.90462386
131Ragged-red muscle fibers (HP:0003200)1.87899104
132Chronic diarrhea (HP:0002028)1.87637869
133Abnormality of the 1st metacarpal (HP:0010009)1.87180628
134Microretrognathia (HP:0000308)1.85086185
135Nephritis (HP:0000123)1.84759076
136Petechiae (HP:0000967)1.82183803
137Seborrheic dermatitis (HP:0001051)1.80854143
138Abnormality of the proximal phalanges of the hand (HP:0009834)1.76788157
139Hypophosphatemic rickets (HP:0004912)1.76014921
140Proximal tubulopathy (HP:0000114)1.74809169
141Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74367948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.14834299
2EPHA23.76426442
3STK393.54204899
4SMG12.99561948
5ACVR1B2.95731586
6MST1R2.69597512
7NME22.55107360
8OXSR12.52963508
9ERBB42.47181533
10PIM22.43477161
11VRK22.29755391
12WNK42.25673075
13PDK22.20037784
14TESK12.13359745
15STK162.09227910
16ERN12.03109035
17EPHA42.02088098
18ARAF2.00777666
19PBK1.98300893
20MAP2K41.97928417
21SIK11.87341736
22PIK3CA1.79356960
23NME11.75070838
24INSRR1.73997737
25MET1.73790957
26TRIB31.70989738
27MST41.68599295
28TLK11.66468489
29MAPKAPK31.64099393
30FGFR41.61990939
31FRK1.61296276
32TYK21.55899370
33MYLK1.46916483
34MAP3K121.46529151
35CASK1.44663607
36MAP4K11.44416076
37CAMK2G1.43615636
38PKN11.38883515
39TBK11.37282647
40CAMK2B1.35120117
41MAP2K21.30781105
42PRPF4B1.29580012
43PIK3CG1.28376124
44PRKD21.25154641
45LMTK21.24971455
46IRAK31.22376012
47CAMK2D1.21485877
48MAP3K71.19744359
49PRKCI1.17529827
50STK38L1.17105364
51DAPK11.16610554
52GRK61.15678548
53BCR1.14121746
54PTK61.13436546
55ABL21.13152721
56PAK31.09959877
57DAPK21.05673505
58TAOK31.05529020
59MAPK151.02025433
60CAMK2A1.01770536
61MAP3K131.01749736
62NUAK11.01686127
63MATK1.00240209
64PRKAA21.00128448
65PTK2B0.99468833
66PRKCQ0.97651206
67ICK0.97375189
68EPHB10.97229146
69TAOK10.95805107
70TAOK20.94047411
71IKBKB0.92641395
72FGFR20.91474832
73NTRK30.89032978
74MAP2K10.87625128
75MAPKAPK50.82653755
76IRAK20.81518647
77FGR0.80008274
78NTRK10.79638511
79KSR20.78394006
80PRKCG0.77336962
81MAP3K10.76855914
82CAMK1G0.76257570
83RAF10.76216553
84CAMK1D0.75300764
85PRKCZ0.74780499
86RIPK10.74737587
87TESK20.74388761
88CSNK1G30.74259412
89CSNK1G10.73974238
90ROCK20.72378638
91CDK190.72039212
92GRK10.68134721
93CDC42BPA0.67448612
94BLK0.67234576
95MAPK40.66118776
96PDPK10.65916846
97MAP3K40.65120335
98PRKG20.65076583
99PRKACG0.65070557
100ZAP700.64639355
101DAPK30.62572121
102LRRK20.62310636
103FER0.61949995
104TNK20.61585299
105PTK20.61543901
106MAP3K110.60663242
107EPHB20.59812621
108RPS6KA20.59536707
109GSK3A0.58797076
110PKN20.57243277
111SGK2230.56881028
112SGK4940.56881028
113MUSK0.56825685
114TNIK0.56809914
115RPS6KL10.56553662
116RPS6KC10.56553662
117BRAF0.56242558
118ADRBK20.54094971
119RPS6KA60.53955908
120AURKA0.53752725
121CDK90.53407082
122PRKACA0.53051941
123GRK50.52932665
124MAP3K30.52713134
125MAPK110.52262199
126PIM10.52191756
127MOS0.51649668
128ERBB20.50909503
129PRKCA0.49352939
130MAPKAPK20.48847257
131CSNK1A10.48095801
132PINK10.47729529
133CSNK1G20.46182962
134RPS6KB20.46011167
135PRKCD0.45259414
136MAP3K20.44592436
137LIMK10.44225980
138PRKG10.43707809
139PRKACB0.43593371
140PRKCE0.43537995
141CDK140.43062927
142PHKG10.42656454
143PHKG20.42656454
144MAP2K60.42272978
145PDK10.41656381
146HIPK20.41082565
147IKBKE0.40584993
148OBSCN0.40410601
149DYRK1B0.40141947
150BMPR1B0.39210678
151MAPK120.38359129
152KDR0.38067235
153CSNK1A1L0.36872006
154CDK70.36754516
155RPS6KA50.35874189
156SCYL20.33768276
157TAF10.33433774
158CHUK0.32869161

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.72465284
2Nitrogen metabolism_Homo sapiens_hsa009103.01702541
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86290014
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63499547
5Arginine biosynthesis_Homo sapiens_hsa002202.60977829
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57172392
7Butanoate metabolism_Homo sapiens_hsa006502.49225469
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49145740
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48573357
10Sulfur metabolism_Homo sapiens_hsa009202.46212024
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42619314
12Fatty acid degradation_Homo sapiens_hsa000712.38238410
13Tryptophan metabolism_Homo sapiens_hsa003802.34650326
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31254246
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13569640
16Complement and coagulation cascades_Homo sapiens_hsa046102.13498857
17Propanoate metabolism_Homo sapiens_hsa006402.07627645
18Fatty acid elongation_Homo sapiens_hsa000622.02994193
19Peroxisome_Homo sapiens_hsa041461.99493612
20Histidine metabolism_Homo sapiens_hsa003401.96711677
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93101948
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83030322
23Fatty acid metabolism_Homo sapiens_hsa012121.82621716
24Chemical carcinogenesis_Homo sapiens_hsa052041.81108178
25Steroid biosynthesis_Homo sapiens_hsa001001.72050389
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70731308
27Pyruvate metabolism_Homo sapiens_hsa006201.69015190
28PPAR signaling pathway_Homo sapiens_hsa033201.67400186
29Fat digestion and absorption_Homo sapiens_hsa049751.57712061
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54680054
31Retinol metabolism_Homo sapiens_hsa008301.52988028
32beta-Alanine metabolism_Homo sapiens_hsa004101.51516286
33Oxidative phosphorylation_Homo sapiens_hsa001901.48534013
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48239943
35Bile secretion_Homo sapiens_hsa049761.46514805
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40275945
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39168940
38Tyrosine metabolism_Homo sapiens_hsa003501.38990539
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.35809634
40Phenylalanine metabolism_Homo sapiens_hsa003601.35166667
41Caffeine metabolism_Homo sapiens_hsa002321.34677603
42Folate biosynthesis_Homo sapiens_hsa007901.23754602
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21634373
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.18969866
45Carbon metabolism_Homo sapiens_hsa012001.18152979
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.16700818
47Starch and sucrose metabolism_Homo sapiens_hsa005001.15878211
48Arginine and proline metabolism_Homo sapiens_hsa003301.15824605
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14217311
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11803596
51Staphylococcus aureus infection_Homo sapiens_hsa051501.05287271
52Parkinsons disease_Homo sapiens_hsa050121.04832349
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04745619
54Vitamin digestion and absorption_Homo sapiens_hsa049771.03341152
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.01817916
56Other glycan degradation_Homo sapiens_hsa005110.98620052
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98225150
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97369584
59Biosynthesis of amino acids_Homo sapiens_hsa012300.96270393
60Sulfur relay system_Homo sapiens_hsa041220.95376528
61Selenocompound metabolism_Homo sapiens_hsa004500.94788361
62Vitamin B6 metabolism_Homo sapiens_hsa007500.92643465
63Glutathione metabolism_Homo sapiens_hsa004800.89997172
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89119483
65Alzheimers disease_Homo sapiens_hsa050100.88423424
66ABC transporters_Homo sapiens_hsa020100.82857730
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81797192
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79221863
69Glycerolipid metabolism_Homo sapiens_hsa005610.78515652
70Linoleic acid metabolism_Homo sapiens_hsa005910.69560947
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68723826
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68018466
73Metabolic pathways_Homo sapiens_hsa011000.66820073
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.63894790
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56152877
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54354895
77Huntingtons disease_Homo sapiens_hsa050160.52821885
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50605173
79Ribosome_Homo sapiens_hsa030100.49016753
80Fatty acid biosynthesis_Homo sapiens_hsa000610.47815323
81Sphingolipid metabolism_Homo sapiens_hsa006000.43935117
82Ether lipid metabolism_Homo sapiens_hsa005650.43100836
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.42818775
84Pentose phosphate pathway_Homo sapiens_hsa000300.38717915
85Galactose metabolism_Homo sapiens_hsa000520.33138380
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.32109887
87Base excision repair_Homo sapiens_hsa034100.31009415
88Cardiac muscle contraction_Homo sapiens_hsa042600.30230142
89N-Glycan biosynthesis_Homo sapiens_hsa005100.28704953
90Fructose and mannose metabolism_Homo sapiens_hsa000510.28129967
91Arachidonic acid metabolism_Homo sapiens_hsa005900.25219455
92Mineral absorption_Homo sapiens_hsa049780.24778787
93Asthma_Homo sapiens_hsa053100.23719883
94Prion diseases_Homo sapiens_hsa050200.22017958
95Protein export_Homo sapiens_hsa030600.20891140
96Lysine degradation_Homo sapiens_hsa003100.17376786
97Pyrimidine metabolism_Homo sapiens_hsa002400.14734678
98Hepatitis C_Homo sapiens_hsa051600.14414510
99Collecting duct acid secretion_Homo sapiens_hsa049660.12348897
100Renin-angiotensin system_Homo sapiens_hsa046140.10172227
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06612289
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06592488
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.02458225
104Nicotine addiction_Homo sapiens_hsa05033-0.0758290
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0708024
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0466023
107Pancreatic secretion_Homo sapiens_hsa04972-0.0398855
108Insulin resistance_Homo sapiens_hsa04931-0.0322542
109GABAergic synapse_Homo sapiens_hsa04727-0.0318798
110Phototransduction_Homo sapiens_hsa04744-0.0162425
111Glucagon signaling pathway_Homo sapiens_hsa04922-0.0159367
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0146431
113Vibrio cholerae infection_Homo sapiens_hsa05110-0.0130201
114One carbon pool by folate_Homo sapiens_hsa00670-0.0121242
115Protein digestion and absorption_Homo sapiens_hsa04974-0.0061795

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