HDLBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.41297748
2COPI coating of Golgi vesicle (GO:0048205)5.41297748
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.08457952
4COPII vesicle coating (GO:0048208)3.99932104
54-hydroxyproline metabolic process (GO:0019471)3.99896958
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.95341328
7positive regulation of nuclease activity (GO:0032075)3.78397283
8protein localization to endosome (GO:0036010)3.67061083
9protein retention in ER lumen (GO:0006621)3.64949536
10desmosome organization (GO:0002934)3.59232464
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56725629
12adherens junction assembly (GO:0034333)3.56467084
13positive regulation of fatty acid beta-oxidation (GO:0032000)3.52055482
14cell-substrate adherens junction assembly (GO:0007045)3.50951081
15focal adhesion assembly (GO:0048041)3.50951081
16endoplasmic reticulum unfolded protein response (GO:0030968)3.46702992
17regulation of nuclease activity (GO:0032069)3.41127477
18lysine metabolic process (GO:0006553)3.39909369
19lysine catabolic process (GO:0006554)3.39909369
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.39367665
21regulation of fatty acid beta-oxidation (GO:0031998)3.37989766
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.36779173
23cellular response to unfolded protein (GO:0034620)3.33985902
24collagen fibril organization (GO:0030199)3.32861723
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32229116
26ER-nucleus signaling pathway (GO:0006984)3.26796632
27negative regulation of fibrinolysis (GO:0051918)3.25150971
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19049028
29skin morphogenesis (GO:0043589)3.17684212
30alpha-linolenic acid metabolic process (GO:0036109)3.16278135
31regulation of cholesterol homeostasis (GO:2000188)3.13577171
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11504974
33protein hydroxylation (GO:0018126)3.09451714
34negative regulation of fatty acid transport (GO:2000192)3.06277281
35peptidyl-proline hydroxylation (GO:0019511)3.05858398
36proline biosynthetic process (GO:0006561)3.05667393
37cellular response to topologically incorrect protein (GO:0035967)3.04294023
38apoptotic cell clearance (GO:0043277)3.02906475
39plasma membrane repair (GO:0001778)3.02007584
40insulin-like growth factor receptor signaling pathway (GO:0048009)3.01798421
41protein carboxylation (GO:0018214)2.99852999
42peptidyl-glutamic acid carboxylation (GO:0017187)2.99852999
43low-density lipoprotein particle clearance (GO:0034383)2.98889764
44epithelial cell-cell adhesion (GO:0090136)2.95623636
45barbed-end actin filament capping (GO:0051016)2.94156047
46protein heterotrimerization (GO:0070208)2.92936124
47regulation of glucose import in response to insulin stimulus (GO:2001273)2.92768486
48sulfur amino acid catabolic process (GO:0000098)2.92414777
49regulation of early endosome to late endosome transport (GO:2000641)2.91313468
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.87901579
51intestinal cholesterol absorption (GO:0030299)2.86987511
52hippo signaling (GO:0035329)2.86533200
53positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85551964
54epoxygenase P450 pathway (GO:0019373)2.85382440
55homocysteine metabolic process (GO:0050667)2.84799436
56vesicle coating (GO:0006901)2.82897270
57endodermal cell differentiation (GO:0035987)2.82762995
58vascular endothelial growth factor signaling pathway (GO:0038084)2.82642334
59exocrine pancreas development (GO:0031017)2.81481407
602-oxoglutarate metabolic process (GO:0006103)2.79203741
61positive regulation of fatty acid oxidation (GO:0046321)2.76094243
62cysteine metabolic process (GO:0006534)2.74234714
63response to unfolded protein (GO:0006986)2.72752890
64positive regulation of glycogen biosynthetic process (GO:0045725)2.71733314
65semaphorin-plexin signaling pathway (GO:0071526)2.71262417
66retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70966388
67response to endoplasmic reticulum stress (GO:0034976)2.70703195
68endothelial cell morphogenesis (GO:0001886)2.69539148
69establishment of apical/basal cell polarity (GO:0035089)2.69029868
70valine metabolic process (GO:0006573)2.68645106
71L-phenylalanine metabolic process (GO:0006558)2.68037800
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68037800
73L-phenylalanine catabolic process (GO:0006559)2.67767033
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67767033
75cell adhesion mediated by integrin (GO:0033627)2.66444035
76hypotonic response (GO:0006971)2.63974083
77positive regulation of extracellular matrix organization (GO:1903055)2.62601224
78regulation of fibrinolysis (GO:0051917)2.60760442
79negative regulation of cell size (GO:0045792)2.60211246
80negative regulation of chondrocyte differentiation (GO:0032331)2.58957902
81branching involved in mammary gland duct morphogenesis (GO:0060444)2.58640404
82regulation of extracellular matrix disassembly (GO:0010715)2.58221698
83cell migration involved in sprouting angiogenesis (GO:0002042)2.57379800
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56896223
85response to topologically incorrect protein (GO:0035966)2.55123250
86regulation of hippo signaling (GO:0035330)2.54688524
87tricarboxylic acid metabolic process (GO:0072350)2.54662266
88polarized epithelial cell differentiation (GO:0030859)2.54418668
89carnitine shuttle (GO:0006853)2.54408893
90regulation of fatty acid oxidation (GO:0046320)2.54329710
91collagen metabolic process (GO:0032963)2.53592130
92stress fiber assembly (GO:0043149)2.53434858
93hormone catabolic process (GO:0042447)2.53126825
94fatty acid transmembrane transport (GO:1902001)2.52373627
95regulation of translational fidelity (GO:0006450)2.50866081
96bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50684356
97extracellular matrix disassembly (GO:0022617)2.49902965
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49806747
99endocardial cushion development (GO:0003197)2.49446049
100positive regulation of endothelial cell apoptotic process (GO:2000353)2.49414123
101chondrocyte proliferation (GO:0035988)2.49180374
102negative regulation of lipid transport (GO:0032369)2.48637841
103regulation of protein activation cascade (GO:2000257)2.47762807
104regulation of tight junction assembly (GO:2000810)2.47629302
105multicellular organismal macromolecule metabolic process (GO:0044259)2.46692533
106intestinal absorption (GO:0050892)2.45592808
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45060574
108cell-substrate junction assembly (GO:0007044)2.44981560
109basement membrane organization (GO:0071711)2.44299801
110positive regulation of glycolytic process (GO:0045821)2.44282521
111hemidesmosome assembly (GO:0031581)2.44258527
112triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43029099
113glomerular basement membrane development (GO:0032836)2.42830952
114regulation of plasminogen activation (GO:0010755)2.42672397
115urea cycle (GO:0000050)2.41349621
116urea metabolic process (GO:0019627)2.41349621
117positive regulation of histone deacetylation (GO:0031065)2.40882291
118cellular modified amino acid catabolic process (GO:0042219)2.40881963
119maternal placenta development (GO:0001893)2.39896558
120Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.39591026
121complement activation, alternative pathway (GO:0006957)2.39525263
122regulation of complement activation (GO:0030449)2.38837708
123pinocytosis (GO:0006907)2.38759554
124positive regulation of glycogen metabolic process (GO:0070875)2.38402225
125glyoxylate metabolic process (GO:0046487)2.37839656
126membrane protein ectodomain proteolysis (GO:0006509)2.37051872
127cellular response to vitamin D (GO:0071305)2.36650253
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.36246961
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.36173752
130nuclear pore complex assembly (GO:0051292)2.35894882
131growth hormone receptor signaling pathway (GO:0060396)2.35858992
132aspartate family amino acid catabolic process (GO:0009068)2.34960437
133blood vessel endothelial cell migration (GO:0043534)2.34885512
134multicellular organismal metabolic process (GO:0044236)2.34764726
135embryonic process involved in female pregnancy (GO:0060136)2.34738553
136endothelial cell chemotaxis (GO:0035767)2.34575808
137collagen catabolic process (GO:0030574)2.33875029
138paraxial mesoderm development (GO:0048339)2.33694315
139positive regulation of lipid catabolic process (GO:0050996)2.33555255
140folic acid-containing compound biosynthetic process (GO:0009396)2.33415447
141gap junction assembly (GO:0016264)2.32882981
142regulation of establishment of planar polarity (GO:0090175)2.31004074
143protein maturation by protein folding (GO:0022417)2.29863970
144wound healing, spreading of epidermal cells (GO:0035313)2.28434155
145activation of Rac GTPase activity (GO:0032863)2.27599276
146regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.26802842
147sequestering of extracellular ligand from receptor (GO:0035581)2.26753838
148regulation of mammary gland epithelial cell proliferation (GO:0033599)2.26213535
149cell migration involved in heart development (GO:0060973)2.25304274
150kidney mesenchyme development (GO:0072074)2.24116849
151muscle cell migration (GO:0014812)2.23336562
152actin filament depolymerization (GO:0030042)2.23020707
153mesodermal cell differentiation (GO:0048333)2.22626326
154bone trabecula formation (GO:0060346)2.22545002
155negative regulation of protein localization to plasma membrane (GO:1903077)2.22311757
156positive regulation of osteoblast proliferation (GO:0033690)2.22032036
157substrate-dependent cell migration (GO:0006929)2.19766812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.23958402
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.98853334
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.77379712
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60039150
5CLOCK_20551151_ChIP-Seq_293T_Human3.37843671
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37428121
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31785444
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.27200521
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.04474966
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.82270129
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49612909
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.46090685
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40000609
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32827767
15ZNF263_19887448_ChIP-Seq_K562_Human2.24544746
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15620913
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00299574
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96724255
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94613899
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93474023
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.93425764
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86950087
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83273239
24ATF3_27146783_Chip-Seq_COLON_Human1.81872388
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78769932
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.74451069
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.72207435
28AR_21909140_ChIP-Seq_LNCAP_Human1.71635964
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70120685
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.69825106
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.66676125
32* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65351116
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61539994
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61173357
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58202607
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55944366
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54124742
38GATA6_25053715_ChIP-Seq_YYC3_Human1.53140845
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51717999
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51441977
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49706877
42* TBX20_22080862_ChIP-Seq_HEART_Mouse1.49615211
43* TBX20_22328084_ChIP-Seq_HEART_Mouse1.49615211
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.49114704
45RACK7_27058665_Chip-Seq_MCF-7_Human1.48094697
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.45829334
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44327494
48KDM2B_26808549_Chip-Seq_K562_Human1.44258805
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43983001
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42730689
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.40796078
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38704982
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38499946
54* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38251870
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37827436
56E2F7_22180533_ChIP-Seq_HELA_Human1.37593005
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37156239
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34614952
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34445597
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33366352
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32192988
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32192988
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31764777
64BRD4_25478319_ChIP-Seq_HGPS_Human1.31723492
65GATA4_25053715_ChIP-Seq_YYC3_Human1.31450770
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27701935
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25644281
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25486751
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24616703
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24251856
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24055564
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.23985567
73CHD1_26751641_Chip-Seq_LNCaP_Human1.23575302
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23019578
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22687380
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.21491614
77MYC_22102868_ChIP-Seq_BL_Human1.21191156
78* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20787651
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.18869168
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18761558
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18671853
82* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18436315
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18299870
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16711689
85CJUN_26792858_Chip-Seq_BT549_Human1.16007540
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15967078
87* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15656779
88* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13525538
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12145022
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11791327
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09404589
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08860823
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08651826
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08094466
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07748659
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07574303
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07095260
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06860500
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06842049
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.06429323
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05718133
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05679235
103* GATA3_24758297_ChIP-Seq_MCF-7_Human1.05325699
104GATA1_22025678_ChIP-Seq_K562_Human1.05083726
105NCOR1_26117541_ChIP-Seq_K562_Human1.04979829
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04360791
107CREB1_26743006_Chip-Seq_LNCaP_Human1.04037673
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03785628
109* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03442594
110TP53_22127205_ChIP-Seq_IMR90_Human1.03002516
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02934232
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02322620
113* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01092839
114KDM2B_26808549_Chip-Seq_DND41_Human1.00219139
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99198031
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98698002
117* TCF7_22412390_ChIP-Seq_EML_Mouse0.97461213
118LXR_22292898_ChIP-Seq_THP-1_Human0.96925908
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96087945
120* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95203125
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94499902
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94167080
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.93271168
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93104587
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92286092
126* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92027193
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91978816
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91639918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.33827039
2MP0008438_abnormal_cutaneous_collagen4.27184563
3MP0002139_abnormal_hepatobiliary_system2.95427734
4MP0005275_abnormal_skin_tensile2.91190833
5MP0005360_urolithiasis2.52572577
6MP0005365_abnormal_bile_salt2.29267049
7MP0010352_gastrointestinal_tract_polyps2.28666243
8MP0002877_abnormal_melanocyte_morpholog2.24098159
9MP0003252_abnormal_bile_duct2.19247843
10MP0005503_abnormal_tendon_morphology2.17836268
11MP0003566_abnormal_cell_adhesion2.12524354
12MP0005085_abnormal_gallbladder_physiolo2.10405139
13MP0010234_abnormal_vibrissa_follicle2.05044010
14MP0004858_abnormal_nervous_system1.99008276
15MP0003941_abnormal_skin_development1.98762213
16MP0004272_abnormal_basement_membrane1.94012241
17MP0003950_abnormal_plasma_membrane1.80563670
18MP0006054_spinal_hemorrhage1.80414707
19MP0003300_gastrointestinal_ulcer1.75491011
20MP0005451_abnormal_body_composition1.74740357
21MP0005076_abnormal_cell_differentiation1.73216261
22MP0009384_cardiac_valve_regurgitation1.70677323
23MP0005409_darkened_coat_color1.67831045
24MP0003279_aneurysm1.64257242
25MP0003283_abnormal_digestive_organ1.63341630
26MP0002896_abnormal_bone_mineralization1.60730049
27MP0009053_abnormal_anal_canal1.55962668
28MP0001666_abnormal_nutrient_absorption1.52993103
29MP0005623_abnormal_meninges_morphology1.52779628
30MP0005023_abnormal_wound_healing1.52395254
31MP0003806_abnormal_nucleotide_metabolis1.52118972
32MP0005083_abnormal_biliary_tract1.47246293
33MP0004185_abnormal_adipocyte_glucose1.45769391
34MP0004264_abnormal_extraembryonic_tissu1.43325103
35MP0002060_abnormal_skin_morphology1.39569365
36MP0004084_abnormal_cardiac_muscle1.33661990
37MP0010329_abnormal_lipoprotein_level1.33304047
38MP0005220_abnormal_exocrine_pancreas1.32402533
39MP0005666_abnormal_adipose_tissue1.31087726
40MP0000537_abnormal_urethra_morphology1.25654594
41MP0005058_abnormal_lysosome_morphology1.25440415
42MP0000762_abnormal_tongue_morphology1.24272788
43MP0009780_abnormal_chondrocyte_physiolo1.23439338
44MP0000003_abnormal_adipose_tissue1.22407555
45MP0002837_dystrophic_cardiac_calcinosis1.20813372
46MP0001958_emphysema1.20210552
47MP0001661_extended_life_span1.20087795
48MP0005375_adipose_tissue_phenotype1.17882994
49MP0009840_abnormal_foam_cell1.17613960
50MP0000733_abnormal_muscle_development1.17544734
51MP0003453_abnormal_keratinocyte_physiol1.14136445
52MP0003195_calcinosis1.12324771
53MP0001849_ear_inflammation1.12191252
54MP0000759_abnormal_skeletal_muscle1.10454996
55MP0003191_abnormal_cellular_cholesterol1.08265374
56MP0010368_abnormal_lymphatic_system1.07330047
57MP0004087_abnormal_muscle_fiber1.07300111
58MP0008875_abnormal_xenobiotic_pharmacok1.05887879
59MP0003091_abnormal_cell_migration1.04792879
60MP0002796_impaired_skin_barrier1.03746155
61MP0004197_abnormal_fetal_growth/weight/1.03626487
62MP0001348_abnormal_lacrimal_gland1.03234095
63MP0005508_abnormal_skeleton_morphology1.03158025
64MP0005670_abnormal_white_adipose1.02646399
65MP0002089_abnormal_postnatal_growth/wei1.02261909
66MP0005257_abnormal_intraocular_pressure1.01528777
67MP0000747_muscle_weakness1.00839900
68MP0010630_abnormal_cardiac_muscle1.00777575
69MP0000013_abnormal_adipose_tissue0.99768087
70MP0010030_abnormal_orbit_morphology0.98456684
71MP0000609_abnormal_liver_physiology0.97663888
72MP0002269_muscular_atrophy0.96642111
73MP0004130_abnormal_muscle_cell0.96371487
74MP0005187_abnormal_penis_morphology0.96234733
75MP0000467_abnormal_esophagus_morphology0.95673306
76MP0001299_abnormal_eye_distance/0.95671618
77MP0000750_abnormal_muscle_regeneration0.94983794
78MP0005501_abnormal_skin_physiology0.93438018
79MP0003115_abnormal_respiratory_system0.92246243
80MP0000462_abnormal_digestive_system0.91937390
81MP0002108_abnormal_muscle_morphology0.91911783
82MP0004233_abnormal_muscle_weight0.90806640
83MP0003045_fibrosis0.90001723
84MP0009672_abnormal_birth_weight0.89273236
85MP0002168_other_aberrant_phenotype0.87680504
86MP0008260_abnormal_autophagy0.86680319
87MP0005332_abnormal_amino_acid0.85523953
88MP0000163_abnormal_cartilage_morphology0.85035775
89MP0002088_abnormal_embryonic_growth/wei0.85029635
90MP0001243_abnormal_dermal_layer0.84655937
91MP0003868_abnormal_feces_composition0.84542505
92MP0000428_abnormal_craniofacial_morphol0.83757061
93MP0003984_embryonic_growth_retardation0.83743770
94MP0002295_abnormal_pulmonary_circulatio0.83527435
95MP0000767_abnormal_smooth_muscle0.82965716
96MP0000751_myopathy0.82575567
97MP0009250_abnormal_appendicular_skeleto0.82035828
98MP0002086_abnormal_extraembryonic_tissu0.82000647
99MP0002115_abnormal_skeleton_extremities0.81915256
100MP0000749_muscle_degeneration0.81665909
101MP0000534_abnormal_ureter_morphology0.80942093
102MP0005621_abnormal_cell_physiology0.80891327
103MP0000432_abnormal_head_morphology0.79926006
104MP0001944_abnormal_pancreas_morphology0.79543180
105MP0009643_abnormal_urine_homeostasis0.78766733
106MP0005319_abnormal_enzyme/_coenzyme0.78594713
107MP0002118_abnormal_lipid_homeostasis0.78249015
108MP0001542_abnormal_bone_strength0.77790122
109MP0010307_abnormal_tumor_latency0.77723417
110MP0006138_congestive_heart_failure0.77614640
111MP0005330_cardiomyopathy0.77178130
112MP0002697_abnormal_eye_size0.76610782
113MP0000678_abnormal_parathyroid_gland0.76382936
114MP0000598_abnormal_liver_morphology0.75716440
115MP0001672_abnormal_embryogenesis/_devel0.75045401
116MP0005380_embryogenesis_phenotype0.75045401
117MP0001730_embryonic_growth_arrest0.74875308
118MP0000627_abnormal_mammary_gland0.74747484
119MP0005248_abnormal_Harderian_gland0.74359235
120MP0003942_abnormal_urinary_system0.74250263
121MP0001614_abnormal_blood_vessel0.73686654
122MP0003385_abnormal_body_wall0.73634885
123MP0001915_intracranial_hemorrhage0.73600907
124MP0002128_abnormal_blood_circulation0.73501907
125MP0004782_abnormal_surfactant_physiolog0.73116484
126MP0001879_abnormal_lymphatic_vessel0.72908894
127MP0002234_abnormal_pharynx_morphology0.72169840
128MP0002084_abnormal_developmental_patter0.71751889
129MP0002925_abnormal_cardiovascular_devel0.71734278
130MP0003567_abnormal_fetal_cardiomyocyte0.71412503
131MP0009703_decreased_birth_body0.71297338
132MP0005197_abnormal_uvea_morphology0.68987727
133MP0001216_abnormal_epidermal_layer0.68821896
134MP0004036_abnormal_muscle_relaxation0.67180768
135MP0000566_synostosis0.66040168

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.05476622
2Premature rupture of membranes (HP:0001788)4.53079962
3Ankle contracture (HP:0006466)3.37198339
4Vascular tortuosity (HP:0004948)3.36019656
5Cerebral aneurysm (HP:0004944)3.35864037
6Arterial tortuosity (HP:0005116)3.28222432
7Cervical subluxation (HP:0003308)3.17049095
8Shallow orbits (HP:0000586)3.13706477
9Vertebral compression fractures (HP:0002953)3.06978292
10Increased connective tissue (HP:0009025)3.05538159
11Right ventricular cardiomyopathy (HP:0011663)3.01734303
12Deep venous thrombosis (HP:0002625)2.96511603
13Aortic dissection (HP:0002647)2.89816582
14Aortic aneurysm (HP:0004942)2.86018670
15Atrophic scars (HP:0001075)2.85043732
16Hyperacusis (HP:0010780)2.82270594
17Hypoglycemic coma (HP:0001325)2.79650177
18Mitral valve prolapse (HP:0001634)2.77948697
19Aneurysm (HP:0002617)2.67652647
20Peritonitis (HP:0002586)2.61642845
21Hypoplastic ischia (HP:0003175)2.60139273
22Broad metatarsal (HP:0001783)2.50695458
23Xanthomatosis (HP:0000991)2.50566025
24Intrahepatic cholestasis (HP:0001406)2.47567094
25Asymmetry of the thorax (HP:0001555)2.46344258
26Bladder diverticulum (HP:0000015)2.44003408
27Abnormality of the ischium (HP:0003174)2.41922843
28Dilatation of the ascending aorta (HP:0005111)2.40649821
29Flat acetabular roof (HP:0003180)2.39479525
30Achilles tendon contracture (HP:0001771)2.36938598
31Type 1 muscle fiber predominance (HP:0003803)2.35144749
32Abnormality of carpal bone ossification (HP:0006257)2.34982824
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33640963
34Abnormality of the intrinsic pathway (HP:0010989)2.32536494
35Hyperglycemia (HP:0003074)2.30053412
36Genu recurvatum (HP:0002816)2.26287508
37Distal upper limb amyotrophy (HP:0007149)2.26252168
38Upper limb amyotrophy (HP:0009129)2.26252168
39Hand muscle atrophy (HP:0009130)2.26099424
40Metaphyseal cupping (HP:0003021)2.25775647
41Mildly elevated creatine phosphokinase (HP:0008180)2.25017780
42Broad face (HP:0000283)2.24890556
43Back pain (HP:0003418)2.24402436
44Blue sclerae (HP:0000592)2.24197275
45Mitral stenosis (HP:0001718)2.23776816
46Lymphangioma (HP:0100764)2.23032630
47Natal tooth (HP:0000695)2.22807427
48Soft skin (HP:0000977)2.22422982
49Abnormality of the common coagulation pathway (HP:0010990)2.20962513
50Distal lower limb amyotrophy (HP:0008944)2.20827526
51Fragile skin (HP:0001030)2.20164645
52Abnormal ossification of hand bones (HP:0005921)2.18596456
53Hyporeflexia of lower limbs (HP:0002600)2.18095105
54Spinal rigidity (HP:0003306)2.17656724
55Advanced eruption of teeth (HP:0006288)2.17266332
56Mitral regurgitation (HP:0001653)2.16536211
57Joint laxity (HP:0001388)2.15633628
58Hypoalphalipoproteinemia (HP:0003233)2.15102353
59Wormian bones (HP:0002645)2.15101221
60Difficulty climbing stairs (HP:0003551)2.14227724
61Cupped ribs (HP:0000887)2.13211924
62Neonatal short-limb short stature (HP:0008921)2.12227335
63Disproportionate tall stature (HP:0001519)2.09251836
64Abnormality of the acetabulum (HP:0003170)2.07020336
65Ulnar bowing (HP:0003031)2.06342516
66Hyperinsulinemic hypoglycemia (HP:0000825)2.04528771
67Osteolytic defects of the hand bones (HP:0009699)2.03644197
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.03644197
69Abnormal cartilage morphology (HP:0002763)2.03067742
70Abnormality of dentin (HP:0010299)2.02436928
71Long toe (HP:0010511)2.01422851
72Abnormality of skeletal muscle fiber size (HP:0012084)2.01139255
73Overgrowth (HP:0001548)2.00939330
74Subacute progressive viral hepatitis (HP:0006572)2.00424842
75Rectal prolapse (HP:0002035)1.99862187
76Ketoacidosis (HP:0001993)1.97282398
77Renal duplication (HP:0000075)1.97260962
78Distal lower limb muscle weakness (HP:0009053)1.96726303
79Thin bony cortex (HP:0002753)1.95729735
80Myocardial infarction (HP:0001658)1.94749191
81Skin nodule (HP:0200036)1.91353335
82Bowel diverticulosis (HP:0005222)1.90785703
83Abnormality of the distal phalanges of the toes (HP:0010182)1.90007168
84Enlarged penis (HP:0000040)1.89940388
85Ketosis (HP:0001946)1.89899311
86Exostoses (HP:0100777)1.89855125
87Hypolipoproteinemia (HP:0010981)1.87834883
88Breech presentation (HP:0001623)1.87006038
89Tibial bowing (HP:0002982)1.86009924
90Abnormal foot bone ossification (HP:0010675)1.84698033
91Hypoglycemic seizures (HP:0002173)1.82987120
92Insomnia (HP:0100785)1.81944150
93Spinal cord compression (HP:0002176)1.81109571
94Coxa vara (HP:0002812)1.80786002
95Spinal cord lesions (HP:0100561)1.80600727
96Syringomyelia (HP:0003396)1.80600727
97Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79903785
98Radial bowing (HP:0002986)1.79863714
99Ectopia lentis (HP:0001083)1.79460666
100Turricephaly (HP:0000262)1.79291863
101Deviation of the hallux (HP:0010051)1.78969943
102Vertebral arch anomaly (HP:0008438)1.77254584
103Spondylolisthesis (HP:0003302)1.76680401
104Short nail (HP:0001799)1.76480118
105Abnormal hand bone ossification (HP:0010660)1.74933157
106Platyspondyly (HP:0000926)1.74892796
107Round ear (HP:0100830)1.74860061
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74388497
109Slender build (HP:0001533)1.74084612
110Hallux valgus (HP:0001822)1.73584863
111Muscle fiber splitting (HP:0003555)1.73364426
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.73334903
113Protuberant abdomen (HP:0001538)1.73192858
114Myoglobinuria (HP:0002913)1.73138181
115Scapular winging (HP:0003691)1.72182624
116Abnormal delivery (HP:0001787)1.72123165
117Biconcave vertebral bodies (HP:0004586)1.71821886
118Follicular hyperkeratosis (HP:0007502)1.71473495
119Complement deficiency (HP:0004431)1.70538324
120Wrist flexion contracture (HP:0001239)1.70368487
121Abnormality of the calcaneus (HP:0008364)1.69059167
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68920101
123Ankyloglossia (HP:0010296)1.68563067
124Renovascular hypertension (HP:0100817)1.68543445
125Hypobetalipoproteinemia (HP:0003563)1.67869337
126Aortic regurgitation (HP:0001659)1.67767953
127Abnormality of the Achilles tendon (HP:0005109)1.67566970
128Lower limb amyotrophy (HP:0007210)1.67431776
129Hyperextensible skin (HP:0000974)1.67039949
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.66260311
131Hepatocellular carcinoma (HP:0001402)1.65972680
132Cardiovascular calcification (HP:0011915)1.65152634
133Increased variability in muscle fiber diameter (HP:0003557)1.64401403
134Wide anterior fontanel (HP:0000260)1.64392449
135Elbow flexion contracture (HP:0002987)1.64211420
136Generalized amyotrophy (HP:0003700)1.63680265
137Thoracolumbar scoliosis (HP:0002944)1.63562414
138Abnormality of proline metabolism (HP:0010907)1.63313560
139Hydroxyprolinuria (HP:0003080)1.63313560
140Absent frontal sinuses (HP:0002688)1.61066859
141Camptodactyly of toe (HP:0001836)1.60853866
142Abnormality of oral frenula (HP:0000190)1.60648870
143Trismus (HP:0000211)1.60320709
144Neonatal death (HP:0003811)1.58192076
145Inguinal hernia (HP:0000023)1.57038064
146Arnold-Chiari malformation (HP:0002308)1.56012433
147Pterygium (HP:0001059)1.55857623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.30108355
2PKN23.53149740
3LATS13.41384214
4TTN3.10690540
5ERN12.80820236
6SIK12.78053852
7EEF2K2.56173228
8SMG12.49822346
9PDGFRA2.39055881
10DDR22.21565392
11RIPK12.04115464
12PTK62.01782206
13IRAK32.00434574
14FRK1.91499726
15CDK121.88811815
16NTRK11.74982509
17EPHA21.70742349
18BCKDK1.62545117
19PDK31.58255272
20PDK41.58255272
21LATS21.57327517
22STK31.47778145
23SCYL21.47076032
24FLT31.43832803
25MYLK1.43760437
26MAP3K101.42196081
27MTOR1.41845451
28MET1.35087781
29TAOK31.34558091
30PTK21.34325920
31PRKD31.27194061
32AKT31.26714955
33PAK21.25933402
34CAMK1D1.25735290
35FGFR41.25666050
36STK38L1.24785416
37NEK11.23158659
38FER1.22896834
39MAP3K31.20384916
40NEK91.19231211
41PRPF4B1.15988597
42TESK11.14779863
43PASK1.14663025
44INSRR1.11518504
45BMX1.09669799
46LRRK21.08883081
47DMPK1.04163451
48ICK1.02024599
49PDK20.99918537
50CDK60.99477569
51CAMK1G0.96957786
52PRKD20.96506498
53FGFR10.93337131
54TRPM70.92860964
55MAPKAPK30.92043098
56LMTK20.90751022
57EPHA30.90225721
58PDGFRB0.90209755
59PAK40.89395919
60PAK30.88731693
61LIMK10.88701551
62RPS6KB20.88558215
63MAP3K20.85539996
64KSR20.82956056
65MST1R0.82635037
66MAP2K30.80754136
67RPS6KA20.78291596
68RET0.78021629
69NEK20.76301975
70EIF2AK10.73697143
71STK100.71861171
72MOS0.71538726
73FGFR30.70308168
74MAP3K80.70308102
75CDK70.70166544
76PDPK10.65740065
77EPHB10.64900865
78FGFR20.64238253
79PIK3CA0.64023390
80RPS6KA40.62146952
81TGFBR20.62104899
82DYRK1B0.60940027
83ARAF0.60935907
84EPHB20.60904152
85MARK20.60521779
86NME20.56389932
87WNK40.56223129
88MAP3K60.55584357
89ALK0.55203537
90CDC42BPA0.54951744
91TTK0.54937818
92PBK0.54593717
93PIK3CG0.54509092
94TAOK10.54499057
95ROCK20.52948849
96AKT20.51470480
97NUAK10.49448858
98MAP3K70.49095154
99JAK10.48900801
100PRKAA10.48469464
101MAP2K10.47719879
102PRKD10.46187659
103CDK80.45926050
104PIM20.45495541
105CDK40.44949419
106CDK90.44772382
107PRKAA20.43593966
108ROCK10.43216660
109ERBB20.43093318
110TGFBR10.42209117
111BRAF0.41628097
112ILK0.41456603
113SGK30.39949232
114MAP2K20.39940903
115STK380.39657981
116GSK3A0.38624825
117ERBB40.37830261
118BRSK20.37359470
119PRKG20.36331767
120TAOK20.34609878
121MAPK110.34605069
122TYRO30.32038664
123MAP3K130.31787438
124JAK20.31472514
125MELK0.31068530
126PRKCH0.30436167
127BRD40.30336951
128WNK10.30168524
129PTK2B0.29538421
130RPS6KL10.27663265
131RPS6KC10.27663265
132MAP3K90.27239531

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.70461849
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54045909
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30855227
4Fatty acid degradation_Homo sapiens_hsa000712.29466795
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08311737
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03736152
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.00229347
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.99563107
9Arginine biosynthesis_Homo sapiens_hsa002201.94914991
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92637136
11Selenocompound metabolism_Homo sapiens_hsa004501.92148563
12Tryptophan metabolism_Homo sapiens_hsa003801.90198809
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87986822
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84237527
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83979755
16ECM-receptor interaction_Homo sapiens_hsa045121.82662703
17Propanoate metabolism_Homo sapiens_hsa006401.77853793
18Lysine degradation_Homo sapiens_hsa003101.67605035
19Fat digestion and absorption_Homo sapiens_hsa049751.63118396
20PPAR signaling pathway_Homo sapiens_hsa033201.61991530
21Other glycan degradation_Homo sapiens_hsa005111.61706303
22Fatty acid metabolism_Homo sapiens_hsa012121.60921957
23Protein digestion and absorption_Homo sapiens_hsa049741.53747368
24Complement and coagulation cascades_Homo sapiens_hsa046101.50312849
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49798222
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.46820874
27Starch and sucrose metabolism_Homo sapiens_hsa005001.43032175
28Focal adhesion_Homo sapiens_hsa045101.41688412
29Sulfur metabolism_Homo sapiens_hsa009201.41449301
30Pentose phosphate pathway_Homo sapiens_hsa000301.41085176
31Carbon metabolism_Homo sapiens_hsa012001.40932560
32Adherens junction_Homo sapiens_hsa045201.39226798
33Pyruvate metabolism_Homo sapiens_hsa006201.38695461
34Caffeine metabolism_Homo sapiens_hsa002321.36878313
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36412843
36Prion diseases_Homo sapiens_hsa050201.36061722
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32756668
38Insulin resistance_Homo sapiens_hsa049311.30063964
39Biosynthesis of amino acids_Homo sapiens_hsa012301.29515711
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24261364
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21798887
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21709651
43Pancreatic cancer_Homo sapiens_hsa052121.20811079
44One carbon pool by folate_Homo sapiens_hsa006701.17964323
45Bile secretion_Homo sapiens_hsa049761.17146536
46Bladder cancer_Homo sapiens_hsa052191.13540902
47Glioma_Homo sapiens_hsa052141.10944024
48Butanoate metabolism_Homo sapiens_hsa006501.10586885
49Proteoglycans in cancer_Homo sapiens_hsa052051.09264551
50Non-small cell lung cancer_Homo sapiens_hsa052231.08901520
51Renal cell carcinoma_Homo sapiens_hsa052111.04310831
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01436928
53Small cell lung cancer_Homo sapiens_hsa052220.99809194
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99773455
55Vibrio cholerae infection_Homo sapiens_hsa051100.98197087
56Amoebiasis_Homo sapiens_hsa051460.97777174
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.97745846
58Notch signaling pathway_Homo sapiens_hsa043300.96281433
59Vitamin B6 metabolism_Homo sapiens_hsa007500.95302827
60Glucagon signaling pathway_Homo sapiens_hsa049220.93011013
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91945869
62AMPK signaling pathway_Homo sapiens_hsa041520.91547640
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87933719
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86435080
65VEGF signaling pathway_Homo sapiens_hsa043700.86079003
66mTOR signaling pathway_Homo sapiens_hsa041500.85166880
67ErbB signaling pathway_Homo sapiens_hsa040120.84619895
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80997182
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80651672
70beta-Alanine metabolism_Homo sapiens_hsa004100.79692673
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.79635864
72Fatty acid biosynthesis_Homo sapiens_hsa000610.79539659
73Chronic myeloid leukemia_Homo sapiens_hsa052200.78978777
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.78460197
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.78373867
76Estrogen signaling pathway_Homo sapiens_hsa049150.78090649
77Galactose metabolism_Homo sapiens_hsa000520.77203781
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.76741109
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75753057
80Acute myeloid leukemia_Homo sapiens_hsa052210.75635204
81Hippo signaling pathway_Homo sapiens_hsa043900.75615496
82Phenylalanine metabolism_Homo sapiens_hsa003600.75076467
83Chemical carcinogenesis_Homo sapiens_hsa052040.73991967
84Melanoma_Homo sapiens_hsa052180.73958139
85Dilated cardiomyopathy_Homo sapiens_hsa054140.73346634
86Insulin signaling pathway_Homo sapiens_hsa049100.72578003
87Peroxisome_Homo sapiens_hsa041460.72386320
88Arginine and proline metabolism_Homo sapiens_hsa003300.69454927
89MicroRNAs in cancer_Homo sapiens_hsa052060.69070609
90Pathways in cancer_Homo sapiens_hsa052000.68637036
91Tight junction_Homo sapiens_hsa045300.68311022
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68164189
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65430492
94TGF-beta signaling pathway_Homo sapiens_hsa043500.65017913
95ABC transporters_Homo sapiens_hsa020100.64767086
96Glycerolipid metabolism_Homo sapiens_hsa005610.63447379
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61402323
98GnRH signaling pathway_Homo sapiens_hsa049120.61335682
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61185396
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60906925
101Prostate cancer_Homo sapiens_hsa052150.60648729
102Inositol phosphate metabolism_Homo sapiens_hsa005620.60395784
103Endocytosis_Homo sapiens_hsa041440.60197664
104Melanogenesis_Homo sapiens_hsa049160.60141534
105Choline metabolism in cancer_Homo sapiens_hsa052310.59216678
106N-Glycan biosynthesis_Homo sapiens_hsa005100.59155929
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59106149
108HIF-1 signaling pathway_Homo sapiens_hsa040660.58683732
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.58575681
110Renin-angiotensin system_Homo sapiens_hsa046140.58464376
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.58340013
112Histidine metabolism_Homo sapiens_hsa003400.58155011
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57945116
114Gap junction_Homo sapiens_hsa045400.57361859
115Axon guidance_Homo sapiens_hsa043600.57311606
116Prolactin signaling pathway_Homo sapiens_hsa049170.57104795
117Colorectal cancer_Homo sapiens_hsa052100.56733589
118Type II diabetes mellitus_Homo sapiens_hsa049300.54661284
119Tyrosine metabolism_Homo sapiens_hsa003500.54455739
120Endometrial cancer_Homo sapiens_hsa052130.52553742
121Sphingolipid metabolism_Homo sapiens_hsa006000.52145465
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52135022
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51820985
124Thyroid hormone synthesis_Homo sapiens_hsa049180.51691457
125Folate biosynthesis_Homo sapiens_hsa007900.51500234
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51453508
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50537800
128Basal cell carcinoma_Homo sapiens_hsa052170.50183744
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.50051914
130Thyroid cancer_Homo sapiens_hsa052160.49209049
131Vitamin digestion and absorption_Homo sapiens_hsa049770.48956972
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47737947
133Lysosome_Homo sapiens_hsa041420.47516591
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45966474
135Fructose and mannose metabolism_Homo sapiens_hsa000510.45075236
136Viral myocarditis_Homo sapiens_hsa054160.44990302
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41539162
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.39493220

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