HDX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.05663375
2pyrimidine nucleobase catabolic process (GO:0006208)4.97554936
3ionotropic glutamate receptor signaling pathway (GO:0035235)4.78895942
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52597758
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.47379624
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45002090
7synaptic transmission, glutamatergic (GO:0035249)4.44571282
8DNA double-strand break processing (GO:0000729)4.43449240
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.42561028
10synaptic vesicle exocytosis (GO:0016079)4.38545200
11neuron cell-cell adhesion (GO:0007158)4.33486495
12protein localization to synapse (GO:0035418)4.33105899
13glutamate receptor signaling pathway (GO:0007215)4.28883423
14startle response (GO:0001964)4.10712541
15neuron-neuron synaptic transmission (GO:0007270)4.09707092
16positive regulation of synapse maturation (GO:0090129)4.04648676
17neuron recognition (GO:0008038)3.96896969
18axonal fasciculation (GO:0007413)3.92092585
19nucleobase catabolic process (GO:0046113)3.88396473
20protein localization to cilium (GO:0061512)3.88255109
21regulation of glutamate receptor signaling pathway (GO:1900449)3.87256625
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85874325
23dendritic spine morphogenesis (GO:0060997)3.83276145
24limb bud formation (GO:0060174)3.82022392
25synaptic vesicle maturation (GO:0016188)3.81538484
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.81228296
27glutamate secretion (GO:0014047)3.78715242
28regulation of synaptic vesicle exocytosis (GO:2000300)3.78383059
29neurotransmitter-gated ion channel clustering (GO:0072578)3.75902808
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.75084629
31intraciliary transport (GO:0042073)3.75043010
32nonmotile primary cilium assembly (GO:0035058)3.74669196
33locomotory exploration behavior (GO:0035641)3.66279391
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58348579
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51421544
36long-term memory (GO:0007616)3.48530453
37central nervous system projection neuron axonogenesis (GO:0021952)3.43811326
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43631425
39cell migration in hindbrain (GO:0021535)3.41871521
40presynaptic membrane assembly (GO:0097105)3.40780052
41regulation of development, heterochronic (GO:0040034)3.39146821
42layer formation in cerebral cortex (GO:0021819)3.36030844
43transmission of nerve impulse (GO:0019226)3.34380115
44neurotransmitter secretion (GO:0007269)3.33902951
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32080197
46neural tube formation (GO:0001841)3.31718019
47organelle disassembly (GO:1903008)3.29587041
48behavioral defense response (GO:0002209)3.29569030
49behavioral fear response (GO:0001662)3.29569030
50olfactory bulb development (GO:0021772)3.28043681
51neuronal action potential propagation (GO:0019227)3.27606801
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26076676
53ganglion development (GO:0061548)3.25679021
54positive regulation of synapse assembly (GO:0051965)3.25227969
55presynaptic membrane organization (GO:0097090)3.25029867
56gamma-aminobutyric acid transport (GO:0015812)3.24939564
57ribonucleoprotein complex disassembly (GO:0032988)3.22870386
58regulation of timing of cell differentiation (GO:0048505)3.21619930
59protein neddylation (GO:0045116)3.21321341
60cerebellar Purkinje cell differentiation (GO:0021702)3.19939711
61regulation of synapse maturation (GO:0090128)3.19018642
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16750283
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16349423
64cerebellar granule cell differentiation (GO:0021707)3.15499727
65regulation of postsynaptic membrane potential (GO:0060078)3.14752233
66regulation of neuronal synaptic plasticity (GO:0048168)3.14154654
67response to pheromone (GO:0019236)3.14114478
68forebrain neuron differentiation (GO:0021879)3.13474368
69regulation of dendritic spine morphogenesis (GO:0061001)3.13447345
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10816260
71platelet dense granule organization (GO:0060155)3.10124655
72regulation of synaptic vesicle transport (GO:1902803)3.09117954
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.08963793
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.07236289
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06751038
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.06675575
77behavioral response to nicotine (GO:0035095)3.06249063
78postsynaptic membrane organization (GO:0001941)3.04204324
79urinary tract smooth muscle contraction (GO:0014848)3.04116313
80innervation (GO:0060384)3.03883458
81positive regulation of membrane potential (GO:0045838)2.99533506
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97321841
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95381479
84dendrite development (GO:0016358)2.95288788
85fear response (GO:0042596)2.94968475
86sympathetic nervous system development (GO:0048485)2.94246826
87regulation of respiratory system process (GO:0044065)2.93542261
88sequestering of actin monomers (GO:0042989)2.92318509
89glycosphingolipid biosynthetic process (GO:0006688)2.91914690
90proteasome assembly (GO:0043248)2.91619141
91positive regulation of mitochondrial fission (GO:0090141)2.90917698
92cilium morphogenesis (GO:0060271)2.90401483
93somite development (GO:0061053)2.89328341
94exploration behavior (GO:0035640)2.88218416
95prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.86397146
96membrane hyperpolarization (GO:0060081)2.85992050
97regulation of synapse assembly (GO:0051963)2.85905843
98long-term synaptic potentiation (GO:0060291)2.82308523
99regulation of synaptic transmission, GABAergic (GO:0032228)2.81751134
100dendritic spine organization (GO:0097061)2.81501741
101membrane depolarization during action potential (GO:0086010)2.79824188
102peptidyl-histidine modification (GO:0018202)2.79813674
103regulation of respiratory gaseous exchange (GO:0043576)2.78973936
104righting reflex (GO:0060013)2.78877232
105neurotransmitter transport (GO:0006836)2.78674682
106somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78027208
107isotype switching (GO:0045190)2.78027208
108somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78027208
109regulation of neurotransmitter secretion (GO:0046928)2.76502442
110cilium organization (GO:0044782)2.75839922
111kinetochore assembly (GO:0051382)2.74456492
112adult walking behavior (GO:0007628)2.74096550
113learning (GO:0007612)2.74061563
114microtubule anchoring (GO:0034453)2.72286787
115cullin deneddylation (GO:0010388)2.72158351
116dendrite morphogenesis (GO:0048813)2.71834921
117regulation of sarcomere organization (GO:0060297)2.71589004
118central nervous system neuron axonogenesis (GO:0021955)2.71305072
119auditory behavior (GO:0031223)2.71177815
120positive regulation of dendritic spine development (GO:0060999)2.70573829
121isoprenoid biosynthetic process (GO:0008299)2.70367301
122regulation of synapse organization (GO:0050807)2.69614021
123retinal ganglion cell axon guidance (GO:0031290)2.69296835
124cilium assembly (GO:0042384)2.69192122
125cochlea development (GO:0090102)2.68662535
126neuromuscular process (GO:0050905)2.68557889
127regulation of synaptic plasticity (GO:0048167)2.68188511
128pre-miRNA processing (GO:0031054)2.67970817
129membrane depolarization (GO:0051899)2.67075525
130proline transport (GO:0015824)2.66147902
131epithelial cilium movement (GO:0003351)2.66071923
132neuromuscular synaptic transmission (GO:0007274)2.66023912
133cholesterol biosynthetic process (GO:0006695)2.64841789
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63357580
135negative regulation of translation, ncRNA-mediated (GO:0040033)2.63357580
136regulation of translation, ncRNA-mediated (GO:0045974)2.63357580
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61732830
138neuromuscular process controlling balance (GO:0050885)2.61596831
139synapse assembly (GO:0007416)2.60423315
140regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60341963
141pyrimidine dimer repair (GO:0006290)2.59105362
142regulation of dendritic spine development (GO:0060998)2.58523645
143negative regulation of telomere maintenance (GO:0032205)2.58301785
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.57912488
145regulation of vesicle fusion (GO:0031338)2.57268823
146regulation of neurotransmitter transport (GO:0051588)2.56623034
147striatum development (GO:0021756)2.54907819
148neuronal ion channel clustering (GO:0045161)2.54374994
149regulation of neurotransmitter levels (GO:0001505)2.54306448
150negative regulation of mast cell activation (GO:0033004)2.53655360
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.52548217
152regulation of mitotic spindle checkpoint (GO:1903504)2.51206625
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51206625
154DNA damage response, detection of DNA damage (GO:0042769)2.50591000
155protein K11-linked ubiquitination (GO:0070979)2.49934461
156negative regulation of axon guidance (GO:1902668)2.49661703
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48880939
158preassembly of GPI anchor in ER membrane (GO:0016254)2.47692097
159cornea development in camera-type eye (GO:0061303)2.46334742
160negative regulation of DNA recombination (GO:0045910)2.46285153
161sterol biosynthetic process (GO:0016126)2.45313962
162regulation of collateral sprouting (GO:0048670)2.44131311
163regulation of telomere maintenance via telomerase (GO:0032210)2.43766441
164regulation of hexokinase activity (GO:1903299)2.43232917
165regulation of glucokinase activity (GO:0033131)2.43232917
166acrosome assembly (GO:0001675)2.42882268
167membrane budding (GO:0006900)2.41828413
168photoreceptor cell maintenance (GO:0045494)2.41532239
169attachment of spindle microtubules to kinetochore (GO:0008608)2.40858161
170chromatin remodeling at centromere (GO:0031055)2.39791169
171anterior/posterior axis specification, embryo (GO:0008595)2.37881514
172regulation of telomere maintenance (GO:0032204)2.37401697
173water-soluble vitamin biosynthetic process (GO:0042364)2.37144990
174protein K48-linked ubiquitination (GO:0070936)2.35904922
175behavioral response to ethanol (GO:0048149)2.34866232
176regulation of oligodendrocyte differentiation (GO:0048713)2.34456862
177histone H2A ubiquitination (GO:0033522)2.34280008
178negative chemotaxis (GO:0050919)2.32996266
179regulation of helicase activity (GO:0051095)2.31687294
180protein deneddylation (GO:0000338)2.31616695
181cerebral cortex cell migration (GO:0021795)2.30785958
182negative regulation of oligodendrocyte differentiation (GO:0048715)2.29974490
183smoothened signaling pathway (GO:0007224)2.29355878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54799457
2GBX2_23144817_ChIP-Seq_PC3_Human3.92169740
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.79173466
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77843691
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68998463
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67791892
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.58940768
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56612839
9TAF15_26573619_Chip-Seq_HEK293_Human2.40663526
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35234681
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35234681
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.28212361
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25719869
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23761494
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.21297555
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20377653
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16222054
18REST_21632747_ChIP-Seq_MESCs_Mouse2.15545973
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11102348
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.10652100
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00775041
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00026786
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99033168
24FUS_26573619_Chip-Seq_HEK293_Human1.98277817
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96954330
26ELK1_19687146_ChIP-ChIP_HELA_Human1.91638602
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91242089
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90168974
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89589786
30ZNF274_21170338_ChIP-Seq_K562_Hela1.87358283
31DROSHA_22980978_ChIP-Seq_HELA_Human1.87221929
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86864120
33P300_19829295_ChIP-Seq_ESCs_Human1.86678957
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84619263
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84493491
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.81385332
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.80859117
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79331635
39AR_21572438_ChIP-Seq_LNCaP_Human1.78527978
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77255476
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76767997
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.74232474
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72678728
44SMAD4_21799915_ChIP-Seq_A2780_Human1.72259763
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68250810
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67748494
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.67700976
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.67590656
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67455647
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66764404
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64331785
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.64041334
53RNF2_27304074_Chip-Seq_NSC_Mouse1.63731807
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63200339
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61690162
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57321232
57IGF1R_20145208_ChIP-Seq_DFB_Human1.54674269
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.52014523
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.51257047
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50176053
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46918048
62EWS_26573619_Chip-Seq_HEK293_Human1.45677434
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43853135
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43777893
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43139279
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.39901710
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39142730
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37859891
69CBP_20019798_ChIP-Seq_JUKART_Human1.37859891
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37762200
71VDR_22108803_ChIP-Seq_LS180_Human1.34452769
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.33337863
73AR_25329375_ChIP-Seq_VCAP_Human1.31837913
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31427075
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31293209
76STAT3_23295773_ChIP-Seq_U87_Human1.30835138
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.27439559
78IRF1_19129219_ChIP-ChIP_H3396_Human1.26709043
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26080757
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25333074
81TCF4_22108803_ChIP-Seq_LS180_Human1.24166676
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23765821
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.23689321
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23508433
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23508433
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23326351
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.23110740
88MYC_18940864_ChIP-ChIP_HL60_Human1.21875602
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21790882
90P53_22387025_ChIP-Seq_ESCs_Mouse1.21777820
91TCF4_23295773_ChIP-Seq_U87_Human1.21358420
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20608518
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20521191
94BCAT_22108803_ChIP-Seq_LS180_Human1.20444543
95SOX9_26525672_Chip-Seq_HEART_Mouse1.19671510
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.18899118
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17447101
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16416850
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13954731
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.13635879
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13361792
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13032613
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.12942158
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.12862066
105ER_23166858_ChIP-Seq_MCF-7_Human1.12018463
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11436576
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.11301039
108RUNX2_22187159_ChIP-Seq_PCA_Human1.11187262
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11117355
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10751592
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.10624377
112AR_19668381_ChIP-Seq_PC3_Human1.09509514
113SOX2_19829295_ChIP-Seq_ESCs_Human1.08891555
114NANOG_19829295_ChIP-Seq_ESCs_Human1.08891555
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08462291
116PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07869787
117TP53_16413492_ChIP-PET_HCT116_Human1.06133665
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04980210
119CDX2_22108803_ChIP-Seq_LS180_Human1.04053841
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03609631
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.03420286
122VDR_23849224_ChIP-Seq_CD4+_Human1.03065955
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02929817
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02773393
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.02750513
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02462619
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02424903
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.01564059
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01064450
130NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01064450
131SOX2_16153702_ChIP-ChIP_HESCs_Human1.00622480
132P300_18555785_Chip-Seq_ESCs_Mouse0.99951165
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99542417
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99101272
135AHR_22903824_ChIP-Seq_MCF-7_Human0.98664408
136JUN_21703547_ChIP-Seq_K562_Human0.98404634
137TP53_18474530_ChIP-ChIP_U2OS_Human0.97918358
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97079500
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.96341284
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.96004064
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.95052514
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94432804
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93789328
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93733428
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93219830
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91489778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.45788948
2MP0003880_abnormal_central_pattern3.97479043
3MP0003122_maternal_imprinting3.09352345
4MP0003635_abnormal_synaptic_transmissio3.06633067
5MP0003787_abnormal_imprinting2.85965830
6MP0004270_analgesia2.77721554
7MP0003121_genomic_imprinting2.64855568
8MP0000569_abnormal_digit_pigmentation2.57139273
9MP0002063_abnormal_learning/memory/cond2.55630335
10MP0009745_abnormal_behavioral_response2.55223472
11MP0003123_paternal_imprinting2.47481600
12MP0008789_abnormal_olfactory_epithelium2.47419517
13MP0009046_muscle_twitch2.41125628
14MP0002064_seizures2.37744393
15MP0005423_abnormal_somatic_nervous2.30554019
16MP0001968_abnormal_touch/_nociception2.26776512
17MP0006054_spinal_hemorrhage2.22830491
18MP0000778_abnormal_nervous_system2.22002894
19MP0002272_abnormal_nervous_system2.16602438
20MP0002572_abnormal_emotion/affect_behav2.16456725
21MP0002734_abnormal_mechanical_nocicepti2.11100682
22MP0001486_abnormal_startle_reflex2.10417224
23MP0002735_abnormal_chemical_nociception2.08174254
24MP0005253_abnormal_eye_physiology1.96487211
25MP0001293_anophthalmia1.87802525
26MP0002736_abnormal_nociception_after1.86348425
27MP0001529_abnormal_vocalization1.82076315
28MP0002184_abnormal_innervation1.72967220
29MP0003195_calcinosis1.68830466
30MP0008058_abnormal_DNA_repair1.66888176
31MP0002067_abnormal_sensory_capabilities1.64959274
32MP0006292_abnormal_olfactory_placode1.64132593
33MP0002557_abnormal_social/conspecific_i1.57676600
34MP0002653_abnormal_ependyma_morphology1.52321885
35MP0001440_abnormal_grooming_behavior1.49772171
36MP0004133_heterotaxia1.48876943
37MP0001188_hyperpigmentation1.46187228
38MP0009697_abnormal_copulation1.46014710
39MP0008877_abnormal_DNA_methylation1.39740996
40MP0001501_abnormal_sleep_pattern1.39167019
41MP0002233_abnormal_nose_morphology1.36599784
42MP0000566_synostosis1.36290961
43MP0000955_abnormal_spinal_cord1.34239977
44MP0002882_abnormal_neuron_morphology1.32905040
45MP0004811_abnormal_neuron_physiology1.31694564
46MP0005646_abnormal_pituitary_gland1.25512579
47MP0001970_abnormal_pain_threshold1.23119659
48MP0002152_abnormal_brain_morphology1.23064819
49MP0000372_irregular_coat_pigmentation1.22958803
50MP0005367_renal/urinary_system_phenotyp1.22310204
51MP0000516_abnormal_urinary_system1.22310204
52MP0001177_atelectasis1.22125366
53MP0005084_abnormal_gallbladder_morpholo1.22084821
54MP0003567_abnormal_fetal_cardiomyocyte1.22080413
55MP0000427_abnormal_hair_cycle1.21637133
56MP0004885_abnormal_endolymph1.20535557
57MP0003385_abnormal_body_wall1.20237331
58MP0010386_abnormal_urinary_bladder1.19333587
59MP0002282_abnormal_trachea_morphology1.18773078
60MP0001299_abnormal_eye_distance/1.18448557
61MP0003119_abnormal_digestive_system1.18287676
62MP0005391_vision/eye_phenotype1.18155061
63MP0005551_abnormal_eye_electrophysiolog1.17653072
64MP0002733_abnormal_thermal_nociception1.16970290
65MP0002822_catalepsy1.14976108
66MP0002066_abnormal_motor_capabilities/c1.14099617
67MP0003861_abnormal_nervous_system1.13959723
68MP0006276_abnormal_autonomic_nervous1.13685362
69MP0004924_abnormal_behavior1.12822015
70MP0005386_behavior/neurological_phenoty1.12822015
71MP0001485_abnormal_pinna_reflex1.11310343
72MP0005174_abnormal_tail_pigmentation1.11194666
73MP0000631_abnormal_neuroendocrine_gland1.10592153
74MP0005248_abnormal_Harderian_gland1.10528598
75MP0003938_abnormal_ear_development1.09473540
76MP0000537_abnormal_urethra_morphology1.09067106
77MP0002254_reproductive_system_inflammat1.08796270
78MP0010030_abnormal_orbit_morphology1.07628575
79MP0002102_abnormal_ear_morphology1.07470280
80MP0009780_abnormal_chondrocyte_physiolo1.06524850
81MP0002234_abnormal_pharynx_morphology1.06496313
82MP0002090_abnormal_vision1.06173288
83MP0004145_abnormal_muscle_electrophysio1.06024492
84MP0004233_abnormal_muscle_weight1.05673160
85MP0000647_abnormal_sebaceous_gland1.05496340
86MP0002095_abnormal_skin_pigmentation1.04483417
87MP0005195_abnormal_posterior_eye1.03977259
88MP0003283_abnormal_digestive_organ1.03718941
89MP0010094_abnormal_chromosome_stability1.02448671
90MP0006072_abnormal_retinal_apoptosis1.01941644
91MP0002751_abnormal_autonomic_nervous1.01009400
92MP0002752_abnormal_somatic_nervous0.99315673
93MP0002638_abnormal_pupillary_reflex0.98782931
94MP0002837_dystrophic_cardiac_calcinosis0.98657964
95MP0008569_lethality_at_weaning0.97573741
96MP0003941_abnormal_skin_development0.95841151
97MP0002938_white_spotting0.95565881
98MP0003755_abnormal_palate_morphology0.95453092
99MP0004215_abnormal_myocardial_fiber0.94918676
100MP0004142_abnormal_muscle_tone0.94328473
101MP0003632_abnormal_nervous_system0.92773068
102MP0001984_abnormal_olfaction0.92026333
103MP0003221_abnormal_cardiomyocyte_apopto0.91648507
104MP0001286_abnormal_eye_development0.90937598
105MP0005187_abnormal_penis_morphology0.89726642
106MP0005394_taste/olfaction_phenotype0.89007366
107MP0005499_abnormal_olfactory_system0.89007366
108MP0003937_abnormal_limbs/digits/tail_de0.88759610
109MP0000049_abnormal_middle_ear0.88222372
110MP0000534_abnormal_ureter_morphology0.86610955
111MP0003890_abnormal_embryonic-extraembry0.86005290
112MP0003137_abnormal_impulse_conducting0.83771301
113MP0003136_yellow_coat_color0.82935633
114MP0004085_abnormal_heartbeat0.82815537
115MP0003942_abnormal_urinary_system0.82399929
116MP0004858_abnormal_nervous_system0.82379867
117MP0001963_abnormal_hearing_physiology0.82345969
118MP0002249_abnormal_larynx_morphology0.81848543
119MP0006035_abnormal_mitochondrial_morpho0.80940910
120MP0008932_abnormal_embryonic_tissue0.80084423
121MP0003315_abnormal_perineum_morphology0.79861846
122MP0003950_abnormal_plasma_membrane0.79187990
123MP0003879_abnormal_hair_cell0.79074109
124MP0000026_abnormal_inner_ear0.79023437
125MP0002177_abnormal_outer_ear0.78616715
126MP0003718_maternal_effect0.77239442
127MP0000751_myopathy0.77217834
128MP0003631_nervous_system_phenotype0.75435615
129MP0001502_abnormal_circadian_rhythm0.75118435
130MP0002116_abnormal_craniofacial_bone0.70940383
131MP0002081_perinatal_lethality0.70852116
132MP0001905_abnormal_dopamine_level0.69955129
133MP0004742_abnormal_vestibular_system0.69123488
134MP0002082_postnatal_lethality0.68648670
135MP0010770_preweaning_lethality0.68648670

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.82437479
2Epileptic encephalopathy (HP:0200134)4.51642211
3Focal seizures (HP:0007359)4.01364956
4Febrile seizures (HP:0002373)3.75336594
5Myokymia (HP:0002411)3.71956798
6True hermaphroditism (HP:0010459)3.67078268
7Atonic seizures (HP:0010819)3.64036943
8Nephrogenic diabetes insipidus (HP:0009806)3.48886486
9Pancreatic fibrosis (HP:0100732)3.31620563
10Abnormality of midbrain morphology (HP:0002418)3.25528685
11Molar tooth sign on MRI (HP:0002419)3.25528685
12Progressive cerebellar ataxia (HP:0002073)3.22101510
13Pancreatic cysts (HP:0001737)3.19412117
14Abnormality of the labia minora (HP:0012880)3.10772589
15Colon cancer (HP:0003003)3.02698249
16Broad-based gait (HP:0002136)2.97211081
17Abnormality of the renal medulla (HP:0100957)2.94217426
18Hyperventilation (HP:0002883)2.76645998
19Generalized tonic-clonic seizures (HP:0002069)2.76514624
20Chronic hepatic failure (HP:0100626)2.70463222
21Dialeptic seizures (HP:0011146)2.69504170
22Absence seizures (HP:0002121)2.62892621
23Gaze-evoked nystagmus (HP:0000640)2.58335118
24Excessive salivation (HP:0003781)2.56196936
25Drooling (HP:0002307)2.56196936
26Hepatoblastoma (HP:0002884)2.49815466
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.45924164
28Postaxial hand polydactyly (HP:0001162)2.43450149
29Diastasis recti (HP:0001540)2.42350000
30Methylmalonic acidemia (HP:0002912)2.40271055
31Impaired vibration sensation in the lower limbs (HP:0002166)2.39237510
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.38456451
33Absent speech (HP:0001344)2.36235198
34Short tibia (HP:0005736)2.36130956
35Anophthalmia (HP:0000528)2.35782009
36Protruding tongue (HP:0010808)2.35037502
37Postaxial foot polydactyly (HP:0001830)2.33932151
38Bifid tongue (HP:0010297)2.33811643
39Poor coordination (HP:0002370)2.33465593
40Lissencephaly (HP:0001339)2.32473487
41Hip dysplasia (HP:0001385)2.29402947
42Epileptiform EEG discharges (HP:0011182)2.27183992
43Progressive inability to walk (HP:0002505)2.22994404
44Neonatal respiratory distress (HP:0002643)2.21489946
45Aqueductal stenosis (HP:0002410)2.19618578
46Inability to walk (HP:0002540)2.19591800
47Cortical dysplasia (HP:0002539)2.18959576
48Broad foot (HP:0001769)2.18598216
49Genetic anticipation (HP:0003743)2.18027950
50Visual hallucinations (HP:0002367)2.15341509
51Hyperglycinemia (HP:0002154)2.13659383
52Abnormality of the renal cortex (HP:0011035)2.13412426
53Hypoplastic pelvis (HP:0008839)2.12299019
54Oligodactyly (hands) (HP:0001180)2.12125623
55Anencephaly (HP:0002323)2.11250901
56Male pseudohermaphroditism (HP:0000037)2.09048811
57EEG with generalized epileptiform discharges (HP:0011198)2.08873455
58Occipital encephalocele (HP:0002085)2.07637726
59Abnormal lung lobation (HP:0002101)2.07210990
60Hemiparesis (HP:0001269)2.07079464
61Retinal dysplasia (HP:0007973)2.04058228
62Abnormality of the lower motor neuron (HP:0002366)2.03597276
63Decreased testicular size (HP:0008734)2.03312287
64Optic nerve hypoplasia (HP:0000609)2.02514749
65Sclerocornea (HP:0000647)2.02126922
66Renal hypoplasia (HP:0000089)2.01563983
67Short 4th metacarpal (HP:0010044)2.00225037
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00225037
69Volvulus (HP:0002580)1.99866719
70Urinary bladder sphincter dysfunction (HP:0002839)1.99457112
71Preaxial hand polydactyly (HP:0001177)1.98599675
72Aplasia/Hypoplasia of the lens (HP:0008063)1.97109404
73Action tremor (HP:0002345)1.96242377
74Narrow forehead (HP:0000341)1.95278263
75Scanning speech (HP:0002168)1.95027363
76Dysdiadochokinesis (HP:0002075)1.93832904
77Abnormality of the metopic suture (HP:0005556)1.93328567
78Hypsarrhythmia (HP:0002521)1.93282527
79Abnormality of the corticospinal tract (HP:0002492)1.92490386
80Labial hypoplasia (HP:0000066)1.92348689
81Insidious onset (HP:0003587)1.91860464
82Termporal pattern (HP:0011008)1.91860464
833-Methylglutaconic aciduria (HP:0003535)1.91636301
84Truncal ataxia (HP:0002078)1.91559373
85Dyskinesia (HP:0100660)1.91433063
86Abnormality of the astrocytes (HP:0100707)1.90158656
87Astrocytoma (HP:0009592)1.90158656
88Growth hormone deficiency (HP:0000824)1.89569849
89Renal cortical cysts (HP:0000803)1.88958655
90Impaired smooth pursuit (HP:0007772)1.88186551
91Midline defect of the nose (HP:0004122)1.87991330
92Tubulointerstitial nephritis (HP:0001970)1.87083584
93Micropenis (HP:0000054)1.86562659
94Abnormal hair whorl (HP:0010721)1.86512714
95Abnormality of binocular vision (HP:0011514)1.86057852
96Diplopia (HP:0000651)1.86057852
97Supernumerary spleens (HP:0009799)1.84538425
98Amblyopia (HP:0000646)1.84447768
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83629577
100Cutaneous finger syndactyly (HP:0010554)1.83348072
101Gastrointestinal atresia (HP:0002589)1.82901063
102Supernumerary ribs (HP:0005815)1.81978904
103Tented upper lip vermilion (HP:0010804)1.81882484
104Spastic gait (HP:0002064)1.81811263
105Gastroesophageal reflux (HP:0002020)1.80215232
106Abolished electroretinogram (ERG) (HP:0000550)1.79645155
107Hypoplastic female external genitalia (HP:0012815)1.78828932
108Small hand (HP:0200055)1.78731243
109Septo-optic dysplasia (HP:0100842)1.77882826
110Specific learning disability (HP:0001328)1.77219713
111Congenital hepatic fibrosis (HP:0002612)1.76967444
112Methylmalonic aciduria (HP:0012120)1.76870021
113Abnormality of serum amino acid levels (HP:0003112)1.75665454
114Coronal craniosynostosis (HP:0004440)1.75514048
115Supernumerary bones of the axial skeleton (HP:0009144)1.75291390
116Omphalocele (HP:0001539)1.75101008
117Cystic liver disease (HP:0006706)1.74883577
118Glioma (HP:0009733)1.74221730
119Esophageal atresia (HP:0002032)1.73914685
120Gait imbalance (HP:0002141)1.73173266
121Dandy-Walker malformation (HP:0001305)1.72980574
122Medulloblastoma (HP:0002885)1.71883352
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.71387384
124Oligodactyly (HP:0012165)1.71285027
125Pendular nystagmus (HP:0012043)1.71090020
126Dysmetria (HP:0001310)1.69267199
127Abnormality of the antihelix (HP:0009738)1.68977528
128Astigmatism (HP:0000483)1.68643775
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.67908745
130Abnormality of glycine metabolism (HP:0010895)1.67404496
131Abnormality of serine family amino acid metabolism (HP:0010894)1.67404496
132Failure to thrive in infancy (HP:0001531)1.66901325
133Pachygyria (HP:0001302)1.66543633
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.66198616
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66198616
136Aganglionic megacolon (HP:0002251)1.66045352
137Abnormality of ocular smooth pursuit (HP:0000617)1.66027608
138Abnormality of salivation (HP:0100755)1.65579540
139Absent eyebrow (HP:0002223)1.65125533
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64129540
141Hyperglycinuria (HP:0003108)1.63340881
142Acute encephalopathy (HP:0006846)1.63262126
143Limb dystonia (HP:0002451)1.62253767
144Ependymoma (HP:0002888)1.62161764
145Prominent nasal bridge (HP:0000426)1.62155308
146Short foot (HP:0001773)1.61378313
147Optic nerve coloboma (HP:0000588)1.60749671
148Hypothermia (HP:0002045)1.60405136
149Cutaneous syndactyly (HP:0012725)1.58344958
150Intestinal atresia (HP:0011100)1.58271796
151Genital tract atresia (HP:0001827)1.57474951
152Nephronophthisis (HP:0000090)1.57256333
153Hypoplastic left heart (HP:0004383)1.57207878
154Abnormal eating behavior (HP:0100738)1.56707247
155Poor eye contact (HP:0000817)1.56661074
156Urinary urgency (HP:0000012)1.56425465
157Congenital primary aphakia (HP:0007707)1.56152122
158Neoplasm of the heart (HP:0100544)1.55645827
159Widely spaced teeth (HP:0000687)1.55341605
160Trigonocephaly (HP:0000243)1.55199834
161Pointed chin (HP:0000307)1.55104739
162Agitation (HP:0000713)1.54792779
163Autism (HP:0000717)1.54752101
164Abnormality of the nasal septum (HP:0000419)1.54576760
165Polyphagia (HP:0002591)1.54065675
166Vaginal atresia (HP:0000148)1.52580635
167Medial flaring of the eyebrow (HP:0010747)1.52269710
168Incomplete penetrance (HP:0003829)1.52095703
169Severe visual impairment (HP:0001141)1.50597693
170Amyotrophic lateral sclerosis (HP:0007354)1.50569834
171Thickened helices (HP:0000391)1.50419217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.23781522
2TRIM283.77252215
3NTRK33.71102698
4MAP3K43.47246612
5MAP4K23.27195814
6CASK2.92079406
7TAOK32.88058632
8MARK12.81850249
9MAP2K72.62533105
10MAP2K42.49454524
11FRK2.36387401
12MAP3K62.32815100
13PNCK2.23172347
14AKT32.10444784
15MINK12.04404284
16MAP3K121.90443744
17PLK21.88384658
18NTRK21.85668713
19TSSK61.82507503
20MAPK131.81737820
21MAP3K91.78909756
22NUAK11.74656027
23CSNK1G11.70384785
24DYRK31.66444072
25MKNK11.63161337
26MKNK21.55685622
27BCR1.50563056
28KSR11.48498239
29ACVR1B1.47761368
30TNIK1.38088892
31UHMK11.37098636
32PAK61.35186140
33WNK31.25764085
34WEE11.23911086
35PLK41.23561773
36PRPF4B1.22110120
37ZAK1.21989348
38BRSK21.20865502
39SIK31.20222157
40BRD41.19829440
41PRKCG1.18264375
42CCNB11.18037051
43LATS21.16184959
44PRKD31.13504289
45EPHA31.11599574
46RPS6KA41.07038505
47EIF2AK31.06782126
48CDK51.01772770
49PLK31.01002613
50ADRBK20.97370464
51MUSK0.96521565
52NEK60.96442034
53CAMK2B0.95337050
54STK380.95331590
55LIMK10.92999336
56DAPK20.92337483
57CDK190.91791062
58DYRK1A0.91728215
59SRPK10.90646066
60SIK20.88813060
61DAPK10.88514801
62SGK4940.87752465
63SGK2230.87752465
64ERBB40.86164654
65ERBB30.84173308
66CAMK2A0.83917320
67CDK180.83261986
68CDC70.82586571
69NTRK10.82251953
70CSNK1G20.81760859
71CDK140.81702801
72GRK10.81415771
73CDK150.76958663
74FGFR20.76913225
75OXSR10.76438522
76DYRK20.76139215
77PIK3CA0.72273585
78INSRR0.71973783
79NME10.71720441
80FES0.68235937
81VRK10.68185925
82MST40.68056125
83CDK11A0.66921667
84PRKCE0.66328060
85PAK30.66118050
86FGFR10.65991755
87SGK20.63165149
88CAMK2D0.62275173
89CAMKK20.61785000
90PINK10.60986323
91FER0.59447904
92ADRBK10.58684351
93CDK30.56651373
94EPHB20.55761090
95CSNK1A1L0.55460667
96CSNK1E0.55379525
97SGK10.55364916
98CDC42BPA0.55273437
99NEK10.55085256
100STK38L0.54847338
101TIE10.54537806
102ALK0.54366594
103CAMKK10.52866916
104YES10.50752936
105MAPK100.50557922
106ROCK20.49306740
107PKN10.47748761
108CAMK10.47281308
109MARK20.46813940
110PLK10.46693824
111CAMK1G0.46042377
112CDK120.45161740
113CSNK1A10.43772799
114DYRK1B0.43661629
115LATS10.43609430
116BMPR1B0.42982003
117CDK10.42891827
118STK30.42314884
119GRK50.42293978
120GSK3B0.41979493
121RPS6KA30.39693893
122BCKDK0.39028337
123ERBB20.39009617
124BRAF0.38378718
125TGFBR10.37636973
126WNK10.37080733
127PRKDC0.36693854
128TTK0.36552073
129EIF2AK20.35891255
130CDK80.35825073
131CSNK1G30.35616646
132PRKCB0.35438197
133BUB10.34018545
134PDK20.33252879
135ATM0.31226099
136EIF2AK10.30166073
137MAP3K50.28871710
138EGFR0.27883207
139ROCK10.27563108
140CSNK1D0.27349828
141PRKG10.27198551

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.89130439
2Protein export_Homo sapiens_hsa030603.80554607
3Synaptic vesicle cycle_Homo sapiens_hsa047213.16043673
4GABAergic synapse_Homo sapiens_hsa047272.98458641
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97348035
6Circadian entrainment_Homo sapiens_hsa047132.75329937
7Glutamatergic synapse_Homo sapiens_hsa047242.74218272
8Morphine addiction_Homo sapiens_hsa050322.68056752
9Propanoate metabolism_Homo sapiens_hsa006402.49302512
10Basal transcription factors_Homo sapiens_hsa030222.49224052
11Steroid biosynthesis_Homo sapiens_hsa001002.42286743
12Amphetamine addiction_Homo sapiens_hsa050312.41755171
13Long-term potentiation_Homo sapiens_hsa047202.32703136
14Dopaminergic synapse_Homo sapiens_hsa047282.14929202
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07996965
16Olfactory transduction_Homo sapiens_hsa047402.04002329
17Proteasome_Homo sapiens_hsa030502.01855401
18Taste transduction_Homo sapiens_hsa047421.94360491
19Insulin secretion_Homo sapiens_hsa049111.87449672
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81656527
21Long-term depression_Homo sapiens_hsa047301.74590355
22Serotonergic synapse_Homo sapiens_hsa047261.74390862
23Cocaine addiction_Homo sapiens_hsa050301.73190454
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73041172
25Butanoate metabolism_Homo sapiens_hsa006501.72839856
26Non-homologous end-joining_Homo sapiens_hsa034501.62202642
27Fanconi anemia pathway_Homo sapiens_hsa034601.62002961
28Salivary secretion_Homo sapiens_hsa049701.60331725
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60068651
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59031325
31Cholinergic synapse_Homo sapiens_hsa047251.57270552
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54855654
33Axon guidance_Homo sapiens_hsa043601.53276544
34Collecting duct acid secretion_Homo sapiens_hsa049661.53082754
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44497534
36Calcium signaling pathway_Homo sapiens_hsa040201.39488900
37RNA polymerase_Homo sapiens_hsa030201.38966700
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38954915
39Phototransduction_Homo sapiens_hsa047441.36685700
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36577810
41Oxytocin signaling pathway_Homo sapiens_hsa049211.36477217
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36460242
43Homologous recombination_Homo sapiens_hsa034401.34308386
44Renin secretion_Homo sapiens_hsa049241.33319644
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27710367
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26680557
47Oocyte meiosis_Homo sapiens_hsa041141.23958377
48Gap junction_Homo sapiens_hsa045401.23894724
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.22379801
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22263550
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.18848184
52Melanogenesis_Homo sapiens_hsa049161.17811917
53Basal cell carcinoma_Homo sapiens_hsa052171.17733224
54Gastric acid secretion_Homo sapiens_hsa049711.17576001
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14592024
56cAMP signaling pathway_Homo sapiens_hsa040241.13700537
57GnRH signaling pathway_Homo sapiens_hsa049121.10430806
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09121807
59Hedgehog signaling pathway_Homo sapiens_hsa043401.07525657
60Wnt signaling pathway_Homo sapiens_hsa043101.06794196
61Cardiac muscle contraction_Homo sapiens_hsa042601.06726850
62Mismatch repair_Homo sapiens_hsa034301.05855023
63Dilated cardiomyopathy_Homo sapiens_hsa054141.03116189
64Tryptophan metabolism_Homo sapiens_hsa003801.01872162
65Type II diabetes mellitus_Homo sapiens_hsa049301.01850302
66Alcoholism_Homo sapiens_hsa050341.00989540
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99280142
68Vibrio cholerae infection_Homo sapiens_hsa051100.99045904
69ErbB signaling pathway_Homo sapiens_hsa040120.98512941
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95452112
71Nucleotide excision repair_Homo sapiens_hsa034200.94514066
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.93563000
73Caffeine metabolism_Homo sapiens_hsa002320.93238746
74Selenocompound metabolism_Homo sapiens_hsa004500.92313002
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.91429592
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90344906
77Regulation of autophagy_Homo sapiens_hsa041400.90294331
78Pyruvate metabolism_Homo sapiens_hsa006200.90083621
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88003958
80Peroxisome_Homo sapiens_hsa041460.85800635
81Estrogen signaling pathway_Homo sapiens_hsa049150.85653144
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84487253
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84304020
84Hippo signaling pathway_Homo sapiens_hsa043900.82217680
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80455884
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80262944
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77678075
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72223743
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68856863
90Nitrogen metabolism_Homo sapiens_hsa009100.68200971
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68189104
92MAPK signaling pathway_Homo sapiens_hsa040100.67810477
93Glioma_Homo sapiens_hsa052140.67220489
94Circadian rhythm_Homo sapiens_hsa047100.66062738
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65449678
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65384182
97Ras signaling pathway_Homo sapiens_hsa040140.65378644
98Sulfur metabolism_Homo sapiens_hsa009200.64819156
99Rap1 signaling pathway_Homo sapiens_hsa040150.63595909
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62436586
101mRNA surveillance pathway_Homo sapiens_hsa030150.62304911
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61589388
103Fatty acid elongation_Homo sapiens_hsa000620.61475020
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61155163
105Chemical carcinogenesis_Homo sapiens_hsa052040.61143402
106mTOR signaling pathway_Homo sapiens_hsa041500.58677162
107Choline metabolism in cancer_Homo sapiens_hsa052310.58126892
108Cell cycle_Homo sapiens_hsa041100.57121380
109beta-Alanine metabolism_Homo sapiens_hsa004100.56699660
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56626570
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55489967
112Melanoma_Homo sapiens_hsa052180.53867544
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53542036
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52202874
115Folate biosynthesis_Homo sapiens_hsa007900.51890999
116Colorectal cancer_Homo sapiens_hsa052100.51416852
117Dorso-ventral axis formation_Homo sapiens_hsa043200.51140578
118Ovarian steroidogenesis_Homo sapiens_hsa049130.50587785
119Metabolic pathways_Homo sapiens_hsa011000.50177773
120Thyroid hormone synthesis_Homo sapiens_hsa049180.49571416
121Type I diabetes mellitus_Homo sapiens_hsa049400.49129063
122Pancreatic secretion_Homo sapiens_hsa049720.47532085
123Purine metabolism_Homo sapiens_hsa002300.47498774
124Glucagon signaling pathway_Homo sapiens_hsa049220.47287708
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.47012276
126Retinol metabolism_Homo sapiens_hsa008300.46610057
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46528473
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46395047
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42889159
130p53 signaling pathway_Homo sapiens_hsa041150.42490881
131Tight junction_Homo sapiens_hsa045300.42465852
132Oxidative phosphorylation_Homo sapiens_hsa001900.41508726
133Pyrimidine metabolism_Homo sapiens_hsa002400.40412929
134Huntingtons disease_Homo sapiens_hsa050160.38709191
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38674285
136Spliceosome_Homo sapiens_hsa030400.38170591
137RNA transport_Homo sapiens_hsa030130.37379362
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.36481531
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36024673
140Fatty acid metabolism_Homo sapiens_hsa012120.35924281
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35070005
142Linoleic acid metabolism_Homo sapiens_hsa005910.34456922
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34448499
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34421067
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34286215
146Alzheimers disease_Homo sapiens_hsa050100.33830678
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33493999
148Parkinsons disease_Homo sapiens_hsa050120.31414664
149RNA degradation_Homo sapiens_hsa030180.31156873
150Renal cell carcinoma_Homo sapiens_hsa052110.30014141
151Endometrial cancer_Homo sapiens_hsa052130.29201215
152Ether lipid metabolism_Homo sapiens_hsa005650.28758218
153TGF-beta signaling pathway_Homo sapiens_hsa043500.28601886

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