

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.46521698 |
| 2 | nuclear pore organization (GO:0006999) | 6.45468831 |
| 3 | pore complex assembly (GO:0046931) | 4.96298959 |
| 4 | DNA unwinding involved in DNA replication (GO:0006268) | 4.80514080 |
| 5 | mitotic nuclear envelope disassembly (GO:0007077) | 4.70250197 |
| 6 | protein localization to kinetochore (GO:0034501) | 4.69017375 |
| 7 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.57350551 |
| 8 | nuclear envelope disassembly (GO:0051081) | 4.39993872 |
| 9 | membrane disassembly (GO:0030397) | 4.39993872 |
| 10 | IMP biosynthetic process (GO:0006188) | 4.37408718 |
| 11 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.30613481 |
| 12 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.30613481 |
| 13 | nucleobase biosynthetic process (GO:0046112) | 4.20610073 |
| 14 | regulation of histone H3-K9 methylation (GO:0051570) | 4.08611053 |
| 15 | mitotic sister chromatid cohesion (GO:0007064) | 4.05348750 |
| 16 | pre-miRNA processing (GO:0031054) | 4.04130367 |
| 17 | establishment of integrated proviral latency (GO:0075713) | 4.02673664 |
| 18 | DNA replication initiation (GO:0006270) | 4.01853628 |
| 19 | non-recombinational repair (GO:0000726) | 3.96553269 |
| 20 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.96553269 |
| 21 | DNA geometric change (GO:0032392) | 3.91805753 |
| 22 | DNA duplex unwinding (GO:0032508) | 3.91484169 |
| 23 | protein localization to chromosome, centromeric region (GO:0071459) | 3.91101503 |
| 24 | mitotic chromosome condensation (GO:0007076) | 3.87222105 |
| 25 | IMP metabolic process (GO:0046040) | 3.87072205 |
| 26 | negative regulation of histone methylation (GO:0031061) | 3.83528634 |
| 27 | regulation of gene silencing by RNA (GO:0060966) | 3.81945064 |
| 28 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.81945064 |
| 29 | regulation of gene silencing by miRNA (GO:0060964) | 3.81945064 |
| 30 | regulation of translational termination (GO:0006449) | 3.78942575 |
| 31 | ribosome assembly (GO:0042255) | 3.78817532 |
| 32 | heterochromatin organization (GO:0070828) | 3.73298202 |
| 33 | mitotic metaphase plate congression (GO:0007080) | 3.72410837 |
| 34 | purine nucleobase biosynthetic process (GO:0009113) | 3.68921431 |
| 35 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.67029637 |
| 36 | formation of translation preinitiation complex (GO:0001731) | 3.66362974 |
| 37 | regulation of translational fidelity (GO:0006450) | 3.63418060 |
| 38 | protein complex localization (GO:0031503) | 3.60543395 |
| 39 | DNA topological change (GO:0006265) | 3.60481478 |
| 40 | regulation of spindle organization (GO:0090224) | 3.58321850 |
| 41 | regulation of RNA export from nucleus (GO:0046831) | 3.58225604 |
| 42 | maturation of SSU-rRNA (GO:0030490) | 3.52034438 |
| 43 | DNA strand elongation (GO:0022616) | 3.50248527 |
| 44 | sister chromatid segregation (GO:0000819) | 3.49237518 |
| 45 | mitotic sister chromatid segregation (GO:0000070) | 3.47895968 |
| 46 | mitotic spindle checkpoint (GO:0071174) | 3.44965721 |
| 47 | positive regulation of chromosome segregation (GO:0051984) | 3.44372950 |
| 48 | cellular protein complex localization (GO:0034629) | 3.43991421 |
| 49 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.43686300 |
| 50 | chromatin assembly (GO:0031497) | 3.42671936 |
| 51 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.42143548 |
| 52 | regulation of mitotic spindle organization (GO:0060236) | 3.41949368 |
| 53 | nuclear envelope organization (GO:0006998) | 3.41618783 |
| 54 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.41456273 |
| 55 | negative regulation of sister chromatid segregation (GO:0033046) | 3.41456273 |
| 56 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.41456273 |
| 57 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.41456273 |
| 58 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.41456273 |
| 59 | metaphase plate congression (GO:0051310) | 3.37037924 |
| 60 | regulation of helicase activity (GO:0051095) | 3.34747161 |
| 61 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.32738001 |
| 62 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.32738001 |
| 63 | regulation of sister chromatid segregation (GO:0033045) | 3.32738001 |
| 64 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.32373806 |
| 65 | ribosome biogenesis (GO:0042254) | 3.30763858 |
| 66 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.28829738 |
| 67 | mitotic spindle assembly checkpoint (GO:0007094) | 3.28732118 |
| 68 | DNA replication checkpoint (GO:0000076) | 3.28377118 |
| 69 | DNA synthesis involved in DNA repair (GO:0000731) | 3.28271651 |
| 70 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.27534685 |
| 71 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.27534685 |
| 72 | dosage compensation (GO:0007549) | 3.25754898 |
| 73 | chromosome condensation (GO:0030261) | 3.24178851 |
| 74 | kinetochore organization (GO:0051383) | 3.16943794 |
| 75 | histone H2A monoubiquitination (GO:0035518) | 3.15727917 |
| 76 | DNA conformation change (GO:0071103) | 3.15689344 |
| 77 | chromatin assembly or disassembly (GO:0006333) | 3.14908538 |
| 78 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.14741632 |
| 79 | regulation of centrosome cycle (GO:0046605) | 3.08447742 |
| 80 | chromatin remodeling at centromere (GO:0031055) | 3.07145550 |
| 81 | regulation of centriole replication (GO:0046599) | 3.05675091 |
| 82 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.04411795 |
| 83 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.04411795 |
| 84 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.04411795 |
| 85 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.03270390 |
| 86 | DNA replication-independent nucleosome organization (GO:0034724) | 3.03270390 |
| 87 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.03016524 |
| 88 | regulation of centrosome duplication (GO:0010824) | 3.02789863 |
| 89 | chromosome segregation (GO:0007059) | 3.02335423 |
| 90 | tRNA aminoacylation for protein translation (GO:0006418) | 3.02234090 |
| 91 | positive regulation of cell cycle checkpoint (GO:1901978) | 3.01984651 |
| 92 | mitotic recombination (GO:0006312) | 3.01559902 |
| 93 | mRNA transport (GO:0051028) | 2.99647466 |
| 94 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.97608792 |
| 95 | DNA packaging (GO:0006323) | 2.96656772 |
| 96 | amino acid activation (GO:0043038) | 2.96209787 |
| 97 | tRNA aminoacylation (GO:0043039) | 2.96209787 |
| 98 | establishment of chromosome localization (GO:0051303) | 2.96194241 |
| 99 | telomere maintenance via recombination (GO:0000722) | 2.95992713 |
| 100 | regulation of sister chromatid cohesion (GO:0007063) | 2.95989789 |
| 101 | protein localization to chromosome (GO:0034502) | 2.95841257 |
| 102 | protein export from nucleus (GO:0006611) | 2.94901793 |
| 103 | meiotic chromosome segregation (GO:0045132) | 2.94685155 |
| 104 | viral mRNA export from host cell nucleus (GO:0046784) | 2.92415217 |
| 105 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.92146367 |
| 106 | negative regulation of DNA repair (GO:0045738) | 2.91971434 |
| 107 | ATP-dependent chromatin remodeling (GO:0043044) | 2.91805531 |
| 108 | regulation of DNA damage checkpoint (GO:2000001) | 2.91765779 |
| 109 | gene silencing by RNA (GO:0031047) | 2.91450606 |
| 110 | DNA ligation (GO:0006266) | 2.90689765 |
| 111 | regulation of chromosome segregation (GO:0051983) | 2.89820841 |
| 112 | CENP-A containing nucleosome assembly (GO:0034080) | 2.88897272 |
| 113 | determination of adult lifespan (GO:0008340) | 2.87044533 |
| 114 | chaperone-mediated protein complex assembly (GO:0051131) | 2.86885140 |
| 115 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.85327624 |
| 116 | protein K6-linked ubiquitination (GO:0085020) | 2.82922132 |
| 117 | snRNA processing (GO:0016180) | 2.81400918 |
| 118 | regulation of gene silencing (GO:0060968) | 2.78500778 |
| 119 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.78283202 |
| 120 | ribosomal large subunit biogenesis (GO:0042273) | 2.78165574 |
| 121 | snRNA metabolic process (GO:0016073) | 2.78108375 |
| 122 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.77572463 |
| 123 | nucleic acid transport (GO:0050657) | 2.77167981 |
| 124 | RNA transport (GO:0050658) | 2.77167981 |
| 125 | establishment of RNA localization (GO:0051236) | 2.77167981 |
| 126 | spindle checkpoint (GO:0031577) | 2.77073022 |
| 127 | negative regulation of chromosome segregation (GO:0051985) | 2.75815830 |
| 128 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.75439944 |
| 129 | translesion synthesis (GO:0019985) | 2.74361924 |
| 130 | spindle assembly checkpoint (GO:0071173) | 2.72651796 |
| 131 | folic acid metabolic process (GO:0046655) | 2.72178100 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.67875224 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.83611674 |
| 3 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.80018209 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.26694623 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.96498616 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.95345324 |
| 7 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.86932983 |
| 8 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.54671828 |
| 9 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.51466578 |
| 10 | MYC_22102868_ChIP-Seq_BL_Human | 2.36112081 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.32627028 |
| 12 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.23135139 |
| 13 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.20257945 |
| 14 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.19576061 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.12772000 |
| 16 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.05213114 |
| 17 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.1262875 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.91861400 |
| 19 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.88249322 |
| 20 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.87911410 |
| 21 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.85710184 |
| 22 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.84528488 |
| 23 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.83705391 |
| 24 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.80749455 |
| 25 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80700461 |
| 26 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.77886704 |
| 27 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.76651108 |
| 28 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.69013290 |
| 29 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.68330470 |
| 30 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.61815786 |
| 31 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.59644852 |
| 32 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.57377556 |
| 33 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.55795093 |
| 34 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.55710488 |
| 35 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.54918706 |
| 36 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.53582604 |
| 37 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.53164983 |
| 38 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.50623795 |
| 39 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.49872436 |
| 40 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49307856 |
| 41 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.49305804 |
| 42 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.46608532 |
| 43 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.46608532 |
| 44 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.46608532 |
| 45 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.45838835 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43024043 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.40770253 |
| 48 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.38867138 |
| 49 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.38382081 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.38342988 |
| 51 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.36370540 |
| 52 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.33836392 |
| 53 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.32693255 |
| 54 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32604659 |
| 55 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.32522986 |
| 56 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.26775292 |
| 57 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.24343736 |
| 58 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.23829861 |
| 59 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.19996480 |
| 60 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.19993016 |
| 61 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.16951387 |
| 62 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.14828841 |
| 63 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.12650442 |
| 64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.12015413 |
| 65 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.10041866 |
| 66 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09159144 |
| 67 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08323572 |
| 68 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.07125110 |
| 69 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.07049191 |
| 70 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.06748936 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06094259 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.05532785 |
| 73 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.04126981 |
| 74 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.03939324 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03933243 |
| 76 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.99844560 |
| 77 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.99180304 |
| 78 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.99082576 |
| 79 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98508771 |
| 80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.97990737 |
| 81 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.97480279 |
| 82 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.96465524 |
| 83 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.94526429 |
| 84 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.93684955 |
| 85 | * NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.93665594 |
| 86 | GATA1_22025678_ChIP-Seq_K562_Human | 0.93656876 |
| 87 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.93354595 |
| 88 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92858518 |
| 89 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.92788907 |
| 90 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.92691687 |
| 91 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.92087492 |
| 92 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91553373 |
| 93 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90883545 |
| 94 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.90756779 |
| 95 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.89578301 |
| 96 | MYB_26560356_Chip-Seq_TH1_Human | 0.89496938 |
| 97 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.88560258 |
| 98 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.88032280 |
| 99 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.87240834 |
| 100 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.86340721 |
| 101 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.85775972 |
| 102 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.85633929 |
| 103 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.84801947 |
| 104 | UTX_26944678_Chip-Seq_JUKART_Human | 0.84759977 |
| 105 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.83455687 |
| 106 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82968001 |
| 107 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.82770486 |
| 108 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.82596420 |
| 109 | MAF_26560356_Chip-Seq_TH1_Human | 0.82197104 |
| 110 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.81767250 |
| 111 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.81324130 |
| 112 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.80884041 |
| 113 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.80684666 |
| 114 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.79923274 |
| 115 | MYB_26560356_Chip-Seq_TH2_Human | 0.79585001 |
| 116 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.79239271 |
| 117 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.77657594 |
| 118 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.77617691 |
| 119 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.76360044 |
| 120 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.76040064 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.31551285 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.17762039 |
| 3 | MP0008057_abnormal_DNA_replication | 4.17566494 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.98468128 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.75660721 |
| 6 | MP0003077_abnormal_cell_cycle | 3.56068282 |
| 7 | MP0010352_gastrointestinal_tract_polyps | 3.28292094 |
| 8 | MP0010307_abnormal_tumor_latency | 2.91249185 |
| 9 | MP0008058_abnormal_DNA_repair | 2.85424167 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.73819555 |
| 11 | MP0001730_embryonic_growth_arrest | 2.60693911 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.45661484 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.35012304 |
| 14 | MP0003123_paternal_imprinting | 2.34496676 |
| 15 | MP0008007_abnormal_cellular_replicative | 2.33396815 |
| 16 | MP0005076_abnormal_cell_differentiation | 2.28124802 |
| 17 | MP0009697_abnormal_copulation | 2.13376543 |
| 18 | MP0002009_preneoplasia | 2.11557446 |
| 19 | MP0001672_abnormal_embryogenesis/_devel | 1.99831232 |
| 20 | MP0005380_embryogenesis_phenotype | 1.99831232 |
| 21 | MP0003705_abnormal_hypodermis_morpholog | 1.99770018 |
| 22 | MP0008932_abnormal_embryonic_tissue | 1.93883117 |
| 23 | MP0004197_abnormal_fetal_growth/weight/ | 1.87699753 |
| 24 | MP0003984_embryonic_growth_retardation | 1.84746714 |
| 25 | MP0002088_abnormal_embryonic_growth/wei | 1.81745237 |
| 26 | MP0001697_abnormal_embryo_size | 1.81119764 |
| 27 | MP0002086_abnormal_extraembryonic_tissu | 1.77870995 |
| 28 | MP0003786_premature_aging | 1.76441567 |
| 29 | MP0002084_abnormal_developmental_patter | 1.75079637 |
| 30 | MP0004808_abnormal_hematopoietic_stem | 1.70129880 |
| 31 | MP0002080_prenatal_lethality | 1.64227121 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.64133316 |
| 33 | MP0001661_extended_life_span | 1.51775392 |
| 34 | MP0000490_abnormal_crypts_of | 1.50498115 |
| 35 | MP0003890_abnormal_embryonic-extraembry | 1.48294280 |
| 36 | MP0004233_abnormal_muscle_weight | 1.47332570 |
| 37 | MP0003121_genomic_imprinting | 1.45927206 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.37577109 |
| 39 | MP0003566_abnormal_cell_adhesion | 1.37466285 |
| 40 | MP0003763_abnormal_thymus_physiology | 1.36258099 |
| 41 | MP0000313_abnormal_cell_death | 1.33561097 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.27092385 |
| 43 | MP0000703_abnormal_thymus_morphology | 1.24228047 |
| 44 | MP0001293_anophthalmia | 1.19315942 |
| 45 | MP0002398_abnormal_bone_marrow | 1.18780598 |
| 46 | MP0002210_abnormal_sex_determination | 1.16021543 |
| 47 | MP0001915_intracranial_hemorrhage | 1.13502214 |
| 48 | MP0005397_hematopoietic_system_phenotyp | 1.11768880 |
| 49 | MP0001545_abnormal_hematopoietic_system | 1.11768880 |
| 50 | MP0005023_abnormal_wound_healing | 1.10033643 |
| 51 | MP0010234_abnormal_vibrissa_follicle | 1.09804930 |
| 52 | MP0009672_abnormal_birth_weight | 1.09544337 |
| 53 | MP0003806_abnormal_nucleotide_metabolis | 1.08643513 |
| 54 | MP0004272_abnormal_basement_membrane | 1.08636343 |
| 55 | MP0002722_abnormal_immune_system | 1.07918266 |
| 56 | MP0009278_abnormal_bone_marrow | 1.07871965 |
| 57 | MP0009333_abnormal_splenocyte_physiolog | 1.05445522 |
| 58 | MP0002796_impaired_skin_barrier | 1.04930936 |
| 59 | MP0001145_abnormal_male_reproductive | 1.04785431 |
| 60 | MP0003950_abnormal_plasma_membrane | 1.04716031 |
| 61 | MP0000689_abnormal_spleen_morphology | 1.04177156 |
| 62 | MP0005623_abnormal_meninges_morphology | 0.99861143 |
| 63 | MP0009053_abnormal_anal_canal | 0.99552186 |
| 64 | MP0009703_decreased_birth_body | 0.98897738 |
| 65 | MP0000358_abnormal_cell_content/ | 0.97272942 |
| 66 | MP0005501_abnormal_skin_physiology | 0.95259924 |
| 67 | MP0001929_abnormal_gametogenesis | 0.94120085 |
| 68 | MP0003300_gastrointestinal_ulcer | 0.93179353 |
| 69 | MP0002166_altered_tumor_susceptibility | 0.92821963 |
| 70 | MP0010030_abnormal_orbit_morphology | 0.92681977 |
| 71 | MP0001286_abnormal_eye_development | 0.92301151 |
| 72 | MP0000537_abnormal_urethra_morphology | 0.91893308 |
| 73 | MP0005621_abnormal_cell_physiology | 0.90665114 |
| 74 | MP0002060_abnormal_skin_morphology | 0.90413812 |
| 75 | MP0000579_abnormal_nail_morphology | 0.90207984 |
| 76 | MP0001800_abnormal_humoral_immune | 0.87245272 |
| 77 | MP0000733_abnormal_muscle_development | 0.86534410 |
| 78 | MP0000653_abnormal_sex_gland | 0.84585132 |
| 79 | MP0002006_tumorigenesis | 0.84539834 |
| 80 | MP0002429_abnormal_blood_cell | 0.84056109 |
| 81 | MP0005384_cellular_phenotype | 0.83691924 |
| 82 | MP0003303_peritoneal_inflammation | 0.83297131 |
| 83 | MP0006035_abnormal_mitochondrial_morpho | 0.82455198 |
| 84 | MP0003943_abnormal_hepatobiliary_system | 0.80457755 |
| 85 | MP0002092_abnormal_eye_morphology | 0.80435191 |
| 86 | MP0010678_abnormal_skin_adnexa | 0.79214354 |
| 87 | MP0001849_ear_inflammation | 0.78750274 |
| 88 | MP0000569_abnormal_digit_pigmentation | 0.78673463 |
| 89 | MP0003718_maternal_effect | 0.77955415 |
| 90 | MP0000716_abnormal_immune_system | 0.77719742 |
| 91 | MP0003119_abnormal_digestive_system | 0.77515418 |
| 92 | MP0004264_abnormal_extraembryonic_tissu | 0.77445346 |
| 93 | MP0002877_abnormal_melanocyte_morpholog | 0.76414974 |
| 94 | MP0003935_abnormal_craniofacial_develop | 0.76302661 |
| 95 | MP0002111_abnormal_tail_morphology | 0.75977104 |
| 96 | MP0003385_abnormal_body_wall | 0.75528566 |
| 97 | MP0003448_altered_tumor_morphology | 0.75157829 |
| 98 | MP0003315_abnormal_perineum_morphology | 0.75075433 |
| 99 | MP0000627_abnormal_mammary_gland | 0.74256350 |
| 100 | MP0000371_diluted_coat_color | 0.74060586 |
| 101 | MP0000428_abnormal_craniofacial_morphol | 0.73794900 |
| 102 | MP0000762_abnormal_tongue_morphology | 0.73492630 |
| 103 | MP0005395_other_phenotype | 0.73309723 |
| 104 | MP0002925_abnormal_cardiovascular_devel | 0.72595503 |
| 105 | MP0000858_altered_metastatic_potential | 0.72472318 |
| 106 | MP0000477_abnormal_intestine_morphology | 0.71776200 |
| 107 | MP0001346_abnormal_lacrimal_gland | 0.71444871 |
| 108 | MP0002405_respiratory_system_inflammati | 0.71332427 |
| 109 | MP0005408_hypopigmentation | 0.70008527 |
| 110 | MP0003699_abnormal_female_reproductive | 0.69987863 |
| 111 | MP0003115_abnormal_respiratory_system | 0.69608722 |
| 112 | MP0003941_abnormal_skin_development | 0.66456705 |
| 113 | MP0002697_abnormal_eye_size | 0.66319107 |
| 114 | MP0003937_abnormal_limbs/digits/tail_de | 0.66221177 |
| 115 | MP0003436_decreased_susceptibility_to | 0.66199147 |
| 116 | MP0001835_abnormal_antigen_presentation | 0.66159248 |
| 117 | MP0002233_abnormal_nose_morphology | 0.66140630 |
| 118 | MP0008438_abnormal_cutaneous_collagen | 0.65534753 |
| 119 | MP0002452_abnormal_antigen_presenting | 0.65087598 |
| 120 | MP0008770_decreased_survivor_rate | 0.63219136 |
| 121 | MP0002420_abnormal_adaptive_immunity | 0.62761379 |
| 122 | MP0000377_abnormal_hair_follicle | 0.62698575 |
| 123 | MP0000432_abnormal_head_morphology | 0.62450018 |
| 124 | MP0001216_abnormal_epidermal_layer | 0.62072483 |
| 125 | MP0003787_abnormal_imprinting | 0.61464791 |
| 126 | MP0004185_abnormal_adipocyte_glucose | 0.61184843 |
| 127 | MP0005451_abnormal_body_composition | 0.61028981 |
| 128 | MP0001819_abnormal_immune_cell | 0.60900338 |
| 129 | MP0001873_stomach_inflammation | 0.60664098 |
| 130 | MP0008995_early_reproductive_senescence | 0.60616020 |
| 131 | MP0006054_spinal_hemorrhage | 0.60388502 |
| 132 | MP0010155_abnormal_intestine_physiology | 0.59661720 |
| 133 | MP0003221_abnormal_cardiomyocyte_apopto | 0.59308088 |
| 134 | MP0001881_abnormal_mammary_gland | 0.58310482 |
| 135 | MP0003453_abnormal_keratinocyte_physiol | 0.57929224 |
| 136 | MP0003861_abnormal_nervous_system | 0.55674156 |
| 137 | MP0001299_abnormal_eye_distance/ | 0.55295759 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ependymoma (HP:0002888) | 4.49846126 |
| 2 | Medulloblastoma (HP:0002885) | 3.68892386 |
| 3 | Chromsome breakage (HP:0040012) | 3.67259256 |
| 4 | Agnosia (HP:0010524) | 3.56500600 |
| 5 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.35627022 |
| 6 | Selective tooth agenesis (HP:0001592) | 3.33283845 |
| 7 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.29665720 |
| 8 | Astrocytoma (HP:0009592) | 3.27994178 |
| 9 | Abnormality of the astrocytes (HP:0100707) | 3.27994178 |
| 10 | Birth length less than 3rd percentile (HP:0003561) | 3.26828987 |
| 11 | Embryonal renal neoplasm (HP:0011794) | 3.18440259 |
| 12 | Rhabdomyosarcoma (HP:0002859) | 3.16085782 |
| 13 | Colon cancer (HP:0003003) | 3.11944665 |
| 14 | Abnormality of the labia minora (HP:0012880) | 2.99137272 |
| 15 | Abnormality of chromosome stability (HP:0003220) | 2.97334084 |
| 16 | Deviation of the thumb (HP:0009603) | 2.95979119 |
| 17 | Proximal placement of thumb (HP:0009623) | 2.93597109 |
| 18 | Impulsivity (HP:0100710) | 2.88878946 |
| 19 | Basal cell carcinoma (HP:0002671) | 2.86170349 |
| 20 | Volvulus (HP:0002580) | 2.84021249 |
| 21 | Deep philtrum (HP:0002002) | 2.82635428 |
| 22 | Glioma (HP:0009733) | 2.79270755 |
| 23 | Biliary tract neoplasm (HP:0100574) | 2.70735201 |
| 24 | Neoplasm of the oral cavity (HP:0100649) | 2.70208381 |
| 25 | Cortical dysplasia (HP:0002539) | 2.66923204 |
| 26 | Reticulocytopenia (HP:0001896) | 2.65333264 |
| 27 | Prominent nose (HP:0000448) | 2.62837200 |
| 28 | Amaurosis fugax (HP:0100576) | 2.62601535 |
| 29 | Neoplasm of striated muscle (HP:0009728) | 2.57085197 |
| 30 | Degeneration of anterior horn cells (HP:0002398) | 2.53378504 |
| 31 | Abnormality of the anterior horn cell (HP:0006802) | 2.53378504 |
| 32 | Multiple enchondromatosis (HP:0005701) | 2.47236462 |
| 33 | Myelodysplasia (HP:0002863) | 2.46046731 |
| 34 | Ectopic kidney (HP:0000086) | 2.45455588 |
| 35 | Abnormal lung lobation (HP:0002101) | 2.45411833 |
| 36 | Increased nuchal translucency (HP:0010880) | 2.41751607 |
| 37 | Progressive external ophthalmoplegia (HP:0000590) | 2.36055781 |
| 38 | Meckel diverticulum (HP:0002245) | 2.33434051 |
| 39 | 11 pairs of ribs (HP:0000878) | 2.33161685 |
| 40 | Microvesicular hepatic steatosis (HP:0001414) | 2.32989010 |
| 41 | Missing ribs (HP:0000921) | 2.31950223 |
| 42 | Abnormality of the fingertips (HP:0001211) | 2.31925194 |
| 43 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.31915166 |
| 44 | Short 4th metacarpal (HP:0010044) | 2.31915166 |
| 45 | Abnormality of the preputium (HP:0100587) | 2.25875121 |
| 46 | Cafe-au-lait spot (HP:0000957) | 2.25581156 |
| 47 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.24684800 |
| 48 | Breast hypoplasia (HP:0003187) | 2.23746151 |
| 49 | Absent thumb (HP:0009777) | 2.23416806 |
| 50 | Termporal pattern (HP:0011008) | 2.23114645 |
| 51 | Insidious onset (HP:0003587) | 2.23114645 |
| 52 | Patellar aplasia (HP:0006443) | 2.22661516 |
| 53 | Abnormality of the ileum (HP:0001549) | 2.21938251 |
| 54 | Sandal gap (HP:0001852) | 2.21215156 |
| 55 | Long eyelashes (HP:0000527) | 2.21106742 |
| 56 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.17919181 |
| 57 | Gastrointestinal carcinoma (HP:0002672) | 2.17919181 |
| 58 | Abnormal number of incisors (HP:0011064) | 2.16751240 |
| 59 | Facial hemangioma (HP:0000329) | 2.13719209 |
| 60 | Neoplasm of the pancreas (HP:0002894) | 2.12128864 |
| 61 | Choanal atresia (HP:0000453) | 2.10699899 |
| 62 | Facial cleft (HP:0002006) | 2.08109475 |
| 63 | Absent radius (HP:0003974) | 2.08088033 |
| 64 | Spastic diplegia (HP:0001264) | 2.06302140 |
| 65 | Thrombocytosis (HP:0001894) | 2.05820298 |
| 66 | Progressive muscle weakness (HP:0003323) | 2.05461026 |
| 67 | Ankyloglossia (HP:0010296) | 2.04981284 |
| 68 | High pitched voice (HP:0001620) | 2.04537361 |
| 69 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.02335001 |
| 70 | Small intestinal stenosis (HP:0012848) | 2.01521829 |
| 71 | Duodenal stenosis (HP:0100867) | 2.01521829 |
| 72 | Oral leukoplakia (HP:0002745) | 1.98144415 |
| 73 | Asymmetry of the thorax (HP:0001555) | 1.96486861 |
| 74 | Skull defect (HP:0001362) | 1.95491413 |
| 75 | Squamous cell carcinoma (HP:0002860) | 1.94661438 |
| 76 | Cutaneous melanoma (HP:0012056) | 1.94265682 |
| 77 | Sloping forehead (HP:0000340) | 1.93946849 |
| 78 | Abnormality of methionine metabolism (HP:0010901) | 1.91802533 |
| 79 | Heterotopia (HP:0002282) | 1.91223915 |
| 80 | Urethral obstruction (HP:0000796) | 1.90448188 |
| 81 | Acute myeloid leukemia (HP:0004808) | 1.90312971 |
| 82 | Absent forearm bone (HP:0003953) | 1.89702556 |
| 83 | Aplasia involving forearm bones (HP:0009822) | 1.89702556 |
| 84 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.89221192 |
| 85 | Dysmetric saccades (HP:0000641) | 1.89124570 |
| 86 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.87366371 |
| 87 | Leiomyosarcoma (HP:0100243) | 1.86094464 |
| 88 | Uterine leiomyosarcoma (HP:0002891) | 1.86094464 |
| 89 | Short humerus (HP:0005792) | 1.86048191 |
| 90 | Embryonal neoplasm (HP:0002898) | 1.85254925 |
| 91 | Papillary thyroid carcinoma (HP:0002895) | 1.84068604 |
| 92 | Capillary hemangiomas (HP:0005306) | 1.83821795 |
| 93 | Abnormality of chromosome segregation (HP:0002916) | 1.83762585 |
| 94 | Homocystinuria (HP:0002156) | 1.83584279 |
| 95 | Abnormality of homocysteine metabolism (HP:0010919) | 1.83584279 |
| 96 | Relative macrocephaly (HP:0004482) | 1.83267762 |
| 97 | Lymphoma (HP:0002665) | 1.83163136 |
| 98 | Atresia of the external auditory canal (HP:0000413) | 1.82743257 |
| 99 | Abnormality of the carotid arteries (HP:0005344) | 1.82271883 |
| 100 | Clubbing of toes (HP:0100760) | 1.81950414 |
| 101 | Premature ovarian failure (HP:0008209) | 1.80858350 |
| 102 | High anterior hairline (HP:0009890) | 1.80119506 |
| 103 | Arteriovenous malformation (HP:0100026) | 1.79995379 |
| 104 | Spinal muscular atrophy (HP:0007269) | 1.79930947 |
| 105 | Abnormality of the calcaneus (HP:0008364) | 1.79331393 |
| 106 | Carpal bone hypoplasia (HP:0001498) | 1.79076579 |
| 107 | Cutis marmorata (HP:0000965) | 1.78971919 |
| 108 | Low anterior hairline (HP:0000294) | 1.78699226 |
| 109 | Abnormality of the lower motor neuron (HP:0002366) | 1.78574375 |
| 110 | Pseudobulbar signs (HP:0002200) | 1.78241729 |
| 111 | Abnormality of oral frenula (HP:0000190) | 1.78184823 |
| 112 | Neoplasm of the colon (HP:0100273) | 1.77786978 |
| 113 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.77667393 |
| 114 | Single umbilical artery (HP:0001195) | 1.77667393 |
| 115 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.77667393 |
| 116 | Overlapping toe (HP:0001845) | 1.77118733 |
| 117 | Secondary amenorrhea (HP:0000869) | 1.76612815 |
| 118 | Pelvic girdle muscle weakness (HP:0003749) | 1.76566938 |
| 119 | Sparse lateral eyebrow (HP:0005338) | 1.75030100 |
| 120 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.74895399 |
| 121 | Abnormality of the umbilical cord (HP:0010881) | 1.74455903 |
| 122 | IgA deficiency (HP:0002720) | 1.73801008 |
| 123 | Spinal cord lesions (HP:0100561) | 1.73601648 |
| 124 | Syringomyelia (HP:0003396) | 1.73601648 |
| 125 | Increased density of long bones (HP:0006392) | 1.73525781 |
| 126 | Supernumerary spleens (HP:0009799) | 1.73050854 |
| 127 | Supernumerary ribs (HP:0005815) | 1.71895589 |
| 128 | Bone marrow hypocellularity (HP:0005528) | 1.71794824 |
| 129 | Tracheoesophageal fistula (HP:0002575) | 1.71726391 |
| 130 | Abnormal biliary tract morphology (HP:0012440) | 1.71363663 |
| 131 | Skin tags (HP:0010609) | 1.70751221 |
| 132 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.70630303 |
| 133 | Abnormality of the duodenum (HP:0002246) | 1.70065549 |
| 134 | Abnormality of cochlea (HP:0000375) | 1.69326869 |
| 135 | Neoplasm of the small intestine (HP:0100833) | 1.68863615 |
| 136 | Short thumb (HP:0009778) | 1.68718259 |
| 137 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.68408575 |
| 138 | Ovarian neoplasm (HP:0100615) | 1.67595112 |
| 139 | Hyperacusis (HP:0010780) | 1.67439371 |
| 140 | T lymphocytopenia (HP:0005403) | 1.67266435 |
| 141 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.67119540 |
| 142 | Trismus (HP:0000211) | 1.66535266 |
| 143 | Subacute progressive viral hepatitis (HP:0006572) | 1.66316046 |
| 144 | Angiofibromas (HP:0010615) | 1.66247789 |
| 145 | Adenoma sebaceum (HP:0009720) | 1.66247789 |
| 146 | Cellular immunodeficiency (HP:0005374) | 1.65401679 |
| 147 | Anal stenosis (HP:0002025) | 1.65264771 |
| 148 | Uterine neoplasm (HP:0010784) | 1.60651928 |
| 149 | Neoplasm of the adrenal cortex (HP:0100641) | 1.58790669 |
| 150 | Obsessive-compulsive behavior (HP:0000722) | 1.58527287 |
| 151 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.58228356 |
| 152 | Septate vagina (HP:0001153) | 1.58012175 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.40656076 |
| 2 | CDC7 | 4.34664520 |
| 3 | WEE1 | 3.23586450 |
| 4 | EEF2K | 2.88715083 |
| 5 | TSSK6 | 2.87028612 |
| 6 | NEK2 | 2.74023685 |
| 7 | BUB1 | 2.44140179 |
| 8 | PBK | 2.42661556 |
| 9 | TTK | 2.29488219 |
| 10 | SMG1 | 2.06153831 |
| 11 | SRPK1 | 2.02629732 |
| 12 | PKN2 | 2.01995011 |
| 13 | RPS6KB2 | 1.93048235 |
| 14 | BRD4 | 1.89661139 |
| 15 | NEK1 | 1.78860777 |
| 16 | PASK | 1.75922584 |
| 17 | MAP3K10 | 1.75029140 |
| 18 | ATR | 1.74421282 |
| 19 | STK10 | 1.73989115 |
| 20 | EPHA2 | 1.72685142 |
| 21 | CDK4 | 1.68616058 |
| 22 | EIF2AK1 | 1.67654129 |
| 23 | MAP4K1 | 1.66263872 |
| 24 | SCYL2 | 1.62209188 |
| 25 | PLK1 | 1.61992694 |
| 26 | ALK | 1.61770813 |
| 27 | CDK7 | 1.61472601 |
| 28 | CHEK1 | 1.54221167 |
| 29 | MAP3K8 | 1.49848977 |
| 30 | AURKB | 1.49140044 |
| 31 | ACVR1B | 1.46238886 |
| 32 | TAF1 | 1.45961311 |
| 33 | PLK3 | 1.41920209 |
| 34 | MKNK1 | 1.38795531 |
| 35 | PLK4 | 1.31009280 |
| 36 | MST1R | 1.29777632 |
| 37 | CHEK2 | 1.28947393 |
| 38 | MST4 | 1.25872071 |
| 39 | TLK1 | 1.21801363 |
| 40 | BRSK2 | 1.21681395 |
| 41 | PNCK | 1.21338029 |
| 42 | PIM1 | 1.20646952 |
| 43 | MKNK2 | 1.20149295 |
| 44 | RPS6KA4 | 1.19242334 |
| 45 | ATM | 1.18522438 |
| 46 | CDK6 | 1.18416765 |
| 47 | CAMK1G | 1.14978879 |
| 48 | FLT3 | 1.13668659 |
| 49 | MTOR | 1.12657147 |
| 50 | TGFBR1 | 1.12631473 |
| 51 | STK4 | 1.10467993 |
| 52 | LATS2 | 1.05154207 |
| 53 | LATS1 | 1.04516725 |
| 54 | CDK2 | 1.04485774 |
| 55 | STK3 | 1.04414141 |
| 56 | EIF2AK2 | 1.01924423 |
| 57 | PDGFRA | 0.95725479 |
| 58 | TESK2 | 0.92125366 |
| 59 | PAK4 | 0.91011088 |
| 60 | MELK | 0.89665134 |
| 61 | EIF2AK3 | 0.88546962 |
| 62 | TTN | 0.87179235 |
| 63 | JAK3 | 0.83724035 |
| 64 | ERBB4 | 0.81017005 |
| 65 | ZAK | 0.80167893 |
| 66 | TRIB3 | 0.79603917 |
| 67 | BRAF | 0.78482134 |
| 68 | DYRK3 | 0.77623022 |
| 69 | MAP2K3 | 0.75572388 |
| 70 | CDK1 | 0.74528741 |
| 71 | LRRK2 | 0.74410198 |
| 72 | CAMK1D | 0.73746169 |
| 73 | CDK8 | 0.72890523 |
| 74 | PAK2 | 0.72167786 |
| 75 | AURKA | 0.70769342 |
| 76 | CSNK2A2 | 0.67444896 |
| 77 | CSNK1D | 0.65434621 |
| 78 | VRK2 | 0.65192597 |
| 79 | FGFR1 | 0.65068488 |
| 80 | ZAP70 | 0.64677683 |
| 81 | STK24 | 0.63502483 |
| 82 | NME2 | 0.62745516 |
| 83 | VRK1 | 0.62027211 |
| 84 | CDK9 | 0.60646065 |
| 85 | NME1 | 0.59371359 |
| 86 | CSNK1E | 0.58552367 |
| 87 | GRK6 | 0.56447674 |
| 88 | NUAK1 | 0.55693309 |
| 89 | CHUK | 0.55274923 |
| 90 | IRAK3 | 0.55201074 |
| 91 | PRKDC | 0.55126036 |
| 92 | STK38L | 0.53381535 |
| 93 | RAF1 | 0.53323851 |
| 94 | ICK | 0.52898760 |
| 95 | MAP3K9 | 0.51907665 |
| 96 | NEK9 | 0.51255813 |
| 97 | BRSK1 | 0.47412109 |
| 98 | PTK6 | 0.47216100 |
| 99 | CSF1R | 0.45217915 |
| 100 | AKT3 | 0.45205895 |
| 101 | MAPK14 | 0.44911958 |
| 102 | RPS6KA5 | 0.44193641 |
| 103 | MET | 0.43565922 |
| 104 | CLK1 | 0.42990907 |
| 105 | BMX | 0.42849801 |
| 106 | RPS6KB1 | 0.41677033 |
| 107 | MAP3K3 | 0.41629137 |
| 108 | PDK2 | 0.41316481 |
| 109 | NEK6 | 0.40526488 |
| 110 | MARK3 | 0.38925524 |
| 111 | TRIM28 | 0.38459833 |
| 112 | PAK1 | 0.38024655 |
| 113 | ERBB3 | 0.37887028 |
| 114 | PDK3 | 0.37273145 |
| 115 | PDK4 | 0.37273145 |
| 116 | BTK | 0.36697028 |
| 117 | AKT2 | 0.36525843 |
| 118 | FGFR3 | 0.36147847 |
| 119 | FGFR4 | 0.35651750 |
| 120 | CSNK2A1 | 0.35596528 |
| 121 | MAPK1 | 0.35199718 |
| 122 | CCNB1 | 0.34880986 |
| 123 | KSR2 | 0.34485505 |
| 124 | TXK | 0.33074841 |
| 125 | RIPK1 | 0.32620553 |
| 126 | TYK2 | 0.31480290 |
| 127 | GSK3B | 0.31295755 |
| 128 | ITK | 0.30819205 |
| 129 | PTK2 | 0.30628721 |
| 130 | AKT1 | 0.29536494 |
| 131 | WNK1 | 0.29222876 |
| 132 | PRPF4B | 0.28352405 |
| 133 | CDK3 | 0.27787273 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.08250679 |
| 2 | * Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.95861703 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.75575480 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.40713716 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.37895943 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 2.96817495 |
| 7 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.81850439 |
| 8 | Cell cycle_Homo sapiens_hsa04110 | 2.66213316 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.43816500 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.38248788 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.29466476 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.19861171 |
| 13 | RNA polymerase_Homo sapiens_hsa03020 | 2.19481011 |
| 14 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.13613088 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.02289582 |
| 16 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.82333933 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.78946669 |
| 18 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.58269580 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.57575494 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.53975995 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53588321 |
| 22 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.53587909 |
| 23 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.50857537 |
| 24 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.46733468 |
| 25 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.30730097 |
| 26 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.28425972 |
| 27 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.24165485 |
| 28 | Proteasome_Homo sapiens_hsa03050 | 1.23887677 |
| 29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.20932283 |
| 30 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.16581933 |
| 31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.05796649 |
| 32 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.00824998 |
| 33 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.97542032 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.92677065 |
| 35 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.90437405 |
| 36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.89511759 |
| 37 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.89307212 |
| 38 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.88516605 |
| 39 | Lysine degradation_Homo sapiens_hsa00310 | 0.86909273 |
| 40 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.86652312 |
| 41 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.86301443 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.85886209 |
| 43 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.85825963 |
| 44 | Thyroid cancer_Homo sapiens_hsa05216 | 0.84253871 |
| 45 | Legionellosis_Homo sapiens_hsa05134 | 0.79319994 |
| 46 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.79083013 |
| 47 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.78779247 |
| 48 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.78693632 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.77395924 |
| 50 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.75672931 |
| 51 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.73839339 |
| 52 | Measles_Homo sapiens_hsa05162 | 0.72684467 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.71322702 |
| 54 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.71019776 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.70980180 |
| 56 | Colorectal cancer_Homo sapiens_hsa05210 | 0.70789465 |
| 57 | Purine metabolism_Homo sapiens_hsa00230 | 0.67795722 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.66518922 |
| 59 | Adherens junction_Homo sapiens_hsa04520 | 0.66245652 |
| 60 | Viral myocarditis_Homo sapiens_hsa05416 | 0.66241367 |
| 61 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.65849966 |
| 62 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.64497079 |
| 63 | Hepatitis B_Homo sapiens_hsa05161 | 0.63854128 |
| 64 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.62867927 |
| 65 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.60793231 |
| 66 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.59589321 |
| 67 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.59326434 |
| 68 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.58685704 |
| 69 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.57490060 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.56758160 |
| 71 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56076363 |
| 72 | Influenza A_Homo sapiens_hsa05164 | 0.55151753 |
| 73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.54484604 |
| 74 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.53596007 |
| 75 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.52005390 |
| 76 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.51489816 |
| 77 | Glioma_Homo sapiens_hsa05214 | 0.51339825 |
| 78 | Prostate cancer_Homo sapiens_hsa05215 | 0.50509033 |
| 79 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.48808680 |
| 80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.48300785 |
| 81 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.48027286 |
| 82 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.47638770 |
| 83 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.46845775 |
| 84 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.45954964 |
| 85 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43911036 |
| 86 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.43793528 |
| 87 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.43716777 |
| 88 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.43679224 |
| 89 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.43666414 |
| 90 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.42894752 |
| 91 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.42059618 |
| 92 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42017386 |
| 93 | Leishmaniasis_Homo sapiens_hsa05140 | 0.41497277 |
| 94 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.41464989 |
| 95 | Pathways in cancer_Homo sapiens_hsa05200 | 0.41058203 |
| 96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.40185532 |
| 97 | Melanoma_Homo sapiens_hsa05218 | 0.39358573 |
| 98 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.39339718 |
| 99 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.37871575 |
| 100 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.37292495 |
| 101 | Bladder cancer_Homo sapiens_hsa05219 | 0.36592152 |
| 102 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.36572784 |
| 103 | Shigellosis_Homo sapiens_hsa05131 | 0.35612927 |
| 104 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.35366942 |
| 105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.35173728 |
| 106 | Tight junction_Homo sapiens_hsa04530 | 0.34989372 |
| 107 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.34567409 |
| 108 | Endometrial cancer_Homo sapiens_hsa05213 | 0.31148844 |
| 109 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31066712 |
| 110 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.30923729 |
| 111 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.30672200 |
| 112 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.30414414 |
| 113 | Protein export_Homo sapiens_hsa03060 | 0.30081498 |
| 114 | Focal adhesion_Homo sapiens_hsa04510 | 0.29953945 |
| 115 | Allograft rejection_Homo sapiens_hsa05330 | 0.29513282 |
| 116 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.29362356 |
| 117 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.28857443 |
| 118 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.28851078 |
| 119 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.28640753 |
| 120 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.27852813 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.27767656 |
| 122 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.27521982 |
| 123 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.26839894 |
| 124 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.26348191 |
| 125 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.25526630 |
| 126 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.24854991 |
| 127 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24272548 |
| 128 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.21056896 |

