HEATR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)5.59444088
2folic acid-containing compound biosynthetic process (GO:0009396)5.52606909
3nucleobase biosynthetic process (GO:0046112)5.22219979
4DNA unwinding involved in DNA replication (GO:0006268)5.16493119
5IMP metabolic process (GO:0046040)5.15122070
6ribosome assembly (GO:0042255)4.97241325
7nuclear pore organization (GO:0006999)4.84411468
8purine nucleobase biosynthetic process (GO:0009113)4.78268321
9DNA replication initiation (GO:0006270)4.57572960
10DNA replication-dependent nucleosome assembly (GO:0006335)4.53317387
11DNA replication-dependent nucleosome organization (GO:0034723)4.53317387
12nuclear pore complex assembly (GO:0051292)4.47222603
13L-serine metabolic process (GO:0006563)4.41874317
14ribosome biogenesis (GO:0042254)4.31103333
15mitotic nuclear envelope disassembly (GO:0007077)4.22798686
16DNA strand elongation involved in DNA replication (GO:0006271)4.09489814
17folic acid metabolic process (GO:0046655)4.05192186
18protein localization to kinetochore (GO:0034501)3.98522494
19nuclear envelope disassembly (GO:0051081)3.90698674
20membrane disassembly (GO:0030397)3.90698674
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89960594
22mitotic metaphase plate congression (GO:0007080)3.88692228
23maturation of SSU-rRNA (GO:0030490)3.86406590
24DNA strand elongation (GO:0022616)3.85871396
25regulation of spindle organization (GO:0090224)3.80523908
26ribosomal large subunit biogenesis (GO:0042273)3.79662982
27ribonucleoprotein complex biogenesis (GO:0022613)3.77071886
28formation of translation preinitiation complex (GO:0001731)3.73862938
29regulation of translational termination (GO:0006449)3.73101123
30negative regulation of interleukin-12 production (GO:0032695)3.66012489
31serine family amino acid biosynthetic process (GO:0009070)3.56993609
32positive regulation of chromosome segregation (GO:0051984)3.49680939
33rRNA processing (GO:0006364)3.48510845
34DNA replication checkpoint (GO:0000076)3.47033138
35telomere maintenance via semi-conservative replication (GO:0032201)3.43064684
36tetrahydrofolate metabolic process (GO:0046653)3.42658239
37UDP-N-acetylglucosamine metabolic process (GO:0006047)3.40782086
38rRNA metabolic process (GO:0016072)3.39684153
39regulation of translational fidelity (GO:0006450)3.37410235
40glycine metabolic process (GO:0006544)3.36759422
41folic acid-containing compound metabolic process (GO:0006760)3.36710906
42pore complex assembly (GO:0046931)3.31901795
43pteridine-containing compound biosynthetic process (GO:0042559)3.31518963
44nuclear envelope organization (GO:0006998)3.30339680
45mitochondrial RNA metabolic process (GO:0000959)3.29911136
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29638908
47positive regulation of gamma-delta T cell activation (GO:0046645)3.26546727
48protein localization to chromosome, centromeric region (GO:0071459)3.24307087
49DNA duplex unwinding (GO:0032508)3.23303512
50DNA geometric change (GO:0032392)3.20789017
51metaphase plate congression (GO:0051310)3.18360145
52pseudouridine synthesis (GO:0001522)3.17791254
53CENP-A containing nucleosome assembly (GO:0034080)3.16790155
54chromatin remodeling at centromere (GO:0031055)3.15673438
55monoubiquitinated protein deubiquitination (GO:0035520)3.12777493
56regulation of mitotic spindle organization (GO:0060236)3.12098222
57cytoplasmic mRNA processing body assembly (GO:0033962)3.10214950
58spliceosomal snRNP assembly (GO:0000387)3.07366106
59peptidyl-arginine omega-N-methylation (GO:0035247)3.03854356
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.03142761
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03142761
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03142761
63regulation of hippo signaling (GO:0035330)3.02935259
64snRNA transcription (GO:0009301)3.01067920
65mitotic sister chromatid segregation (GO:0000070)3.00432950
66N-acetylneuraminate metabolic process (GO:0006054)3.00167099
67replicative senescence (GO:0090399)2.99868587
68sister chromatid segregation (GO:0000819)2.99784712
69DNA replication-independent nucleosome assembly (GO:0006336)2.98325746
70DNA replication-independent nucleosome organization (GO:0034724)2.98325746
71tRNA aminoacylation for protein translation (GO:0006418)2.97182852
72rRNA modification (GO:0000154)2.94817611
73snRNA processing (GO:0016180)2.93777495
74telomere maintenance via telomere lengthening (GO:0010833)2.92565419
75regulation of RNA export from nucleus (GO:0046831)2.92188209
76cell wall macromolecule catabolic process (GO:0016998)2.91680132
77mitotic spindle checkpoint (GO:0071174)2.91188097
78positive regulation of DNA-templated transcription, initiation (GO:2000144)2.89728405
79mitotic G1 DNA damage checkpoint (GO:0031571)2.89588996
80regulation of establishment of cell polarity (GO:2000114)2.89571493
81cellular response to ethanol (GO:0071361)2.89332462
82spindle checkpoint (GO:0031577)2.89138109
83telomere maintenance via recombination (GO:0000722)2.88853499
84mitotic recombination (GO:0006312)2.88208237
85maturation of 5.8S rRNA (GO:0000460)2.88168083
86negative regulation of chromosome segregation (GO:0051985)2.86146291
87mitotic G1/S transition checkpoint (GO:0044819)2.85434483
88histone-serine phosphorylation (GO:0035404)2.84144994
89amino acid activation (GO:0043038)2.82866461
90tRNA aminoacylation (GO:0043039)2.82866461
91iron ion import (GO:0097286)2.81352671
92negative regulation of mitotic sister chromatid separation (GO:2000816)2.81302809
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81302809
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81302809
95negative regulation of sister chromatid segregation (GO:0033046)2.81302809
96mitotic sister chromatid cohesion (GO:0007064)2.80515771
97chaperone-mediated protein complex assembly (GO:0051131)2.80108608
98mitotic spindle assembly checkpoint (GO:0007094)2.79609265
99regulation of posttranscriptional gene silencing (GO:0060147)2.79584736
100regulation of gene silencing by miRNA (GO:0060964)2.79584736
101regulation of gene silencing by RNA (GO:0060966)2.79584736
102snRNA metabolic process (GO:0016073)2.77462101
103spindle assembly checkpoint (GO:0071173)2.76290340
104regulation of chromosome segregation (GO:0051983)2.74963255
105rRNA catabolic process (GO:0016075)2.73121823
106translational initiation (GO:0006413)2.72947065
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.72407706
108chromatin assembly or disassembly (GO:0006333)2.72011929
109histone H3-K36 demethylation (GO:0070544)2.71927359
110termination of RNA polymerase I transcription (GO:0006363)2.71887427
111aspartate family amino acid biosynthetic process (GO:0009067)2.71229416
112mannose metabolic process (GO:0006013)2.70910077
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70274326
114mitotic chromosome condensation (GO:0007076)2.69734932
115ncRNA processing (GO:0034470)2.69537889
116protein complex localization (GO:0031503)2.69417108
117pteridine-containing compound metabolic process (GO:0042558)2.69181047
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.69170240
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68966705
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.68966705
121cell cycle G1/S phase transition (GO:0044843)2.68889184
122G1/S transition of mitotic cell cycle (GO:0000082)2.68889184
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67128353
124histone mRNA catabolic process (GO:0071044)2.66975974
125regulation of centriole replication (GO:0046599)2.66836690
126regulation of gamma-delta T cell activation (GO:0046643)2.66302962
127necroptotic process (GO:0070266)2.66166410
128positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62594325
129rRNA methylation (GO:0031167)2.60746196
130positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.57698280
131phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.55556228
132kynurenine metabolic process (GO:0070189)2.54490798
133negative regulation of TOR signaling (GO:0032007)2.54467002
134histone H3-K4 trimethylation (GO:0080182)2.49096752
135peptidyl-lysine trimethylation (GO:0018023)2.45957304
136regulation of centrosome duplication (GO:0010824)2.43792404
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43719039
138pre-miRNA processing (GO:0031054)2.43638695
139response to peptidoglycan (GO:0032494)2.43595004
140ncRNA catabolic process (GO:0034661)2.40753882
141somatic diversification of immunoglobulins (GO:0016445)2.40525323
142response to pheromone (GO:0019236)2.39991047
143transcription from mitochondrial promoter (GO:0006390)2.39572575
144regulation of interferon-beta production (GO:0032648)2.39478895
145Golgi to endosome transport (GO:0006895)2.39183069
146peptidyl-lysine methylation (GO:0018022)2.38910386
147spindle assembly (GO:0051225)2.38609828
148phosphatidylethanolamine biosynthetic process (GO:0006646)2.38145581
149interkinetic nuclear migration (GO:0022027)2.38100675
150regulation of histone H3-K27 methylation (GO:0061085)2.36755288
151regulation of gamma-delta T cell differentiation (GO:0045586)2.36656742
152gene silencing by RNA (GO:0031047)2.35237783
153neural tube formation (GO:0001841)2.34814851
154hepatocyte apoptotic process (GO:0097284)2.33913497
155somatic recombination of immunoglobulin gene segments (GO:0016447)2.31650041
156phosphatidylethanolamine metabolic process (GO:0046337)2.30064124
157DNA packaging (GO:0006323)2.29453138
158regulation of centrosome cycle (GO:0046605)2.27347498
159oligosaccharide catabolic process (GO:0009313)2.26591734
160response to UV-C (GO:0010225)2.26232333
161DNA conformation change (GO:0071103)2.25507773
162regulation of histone H3-K9 methylation (GO:0051570)2.23807119
163chromosome condensation (GO:0030261)2.23778086
164positive regulation of interferon-beta production (GO:0032728)2.23470390
165replication fork processing (GO:0031297)2.23119165
166indole-containing compound catabolic process (GO:0042436)2.22047998
167indolalkylamine catabolic process (GO:0046218)2.22047998
168tryptophan catabolic process (GO:0006569)2.22047998
169cell wall macromolecule metabolic process (GO:0044036)2.21646958
170regulation of sister chromatid cohesion (GO:0007063)2.20327871
171cellular extravasation (GO:0045123)2.20053671
172regulation of B cell receptor signaling pathway (GO:0050855)2.19329669
173DNA synthesis involved in DNA repair (GO:0000731)2.15787823
174sphingosine metabolic process (GO:0006670)2.15760360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19307309
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.70183898
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.82289960
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.57794856
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48870223
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44661083
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31579056
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15794506
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05863084
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.86969586
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82821420
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.73696897
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70106815
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66645658
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.60371032
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55090927
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55023933
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48442368
19AR_21909140_ChIP-Seq_LNCAP_Human2.38114250
20XRN2_22483619_ChIP-Seq_HELA_Human2.31942801
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29805225
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.27316559
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26726001
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13544166
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11402610
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07722137
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02347699
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99755226
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.96920859
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.94878828
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94561830
32VDR_23849224_ChIP-Seq_CD4+_Human1.93240400
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93011286
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88536502
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85586427
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82729951
37DCP1A_22483619_ChIP-Seq_HELA_Human1.81259044
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81163458
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79080989
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78782306
41KDM5A_27292631_Chip-Seq_BREAST_Human1.77786486
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75239719
43FOXP3_21729870_ChIP-Seq_TREG_Human1.74820195
44* SPI1_23547873_ChIP-Seq_NB4_Human1.70117979
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68869713
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68799218
47* GABP_19822575_ChIP-Seq_HepG2_Human1.67062897
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65604359
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63396888
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63209424
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61938531
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61493209
53* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60766117
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60412175
55TTF2_22483619_ChIP-Seq_HELA_Human1.59812002
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57105890
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56930036
58MYB_26560356_Chip-Seq_TH2_Human1.56907568
59MYC_22102868_ChIP-Seq_BL_Human1.53493451
60ELK1_19687146_ChIP-ChIP_HELA_Human1.52869569
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50853017
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49928532
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49107350
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.47059884
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46928622
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.46574475
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45040130
68ZNF274_21170338_ChIP-Seq_K562_Hela1.42017361
69MYB_26560356_Chip-Seq_TH1_Human1.40577072
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35555934
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35389529
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34816467
73* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34088203
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33661709
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31011153
76PU_27001747_Chip-Seq_BMDM_Mouse1.30711750
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30587664
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30310570
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28133747
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28036082
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27593931
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27321535
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26151648
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25884995
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24584935
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23238839
87GATA3_26560356_Chip-Seq_TH2_Human1.23067775
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23010222
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22804688
90CIITA_25753668_ChIP-Seq_RAJI_Human1.22692747
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21436344
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17852343
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16565324
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16268865
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14700902
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14700902
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14700902
98TFEB_21752829_ChIP-Seq_HELA_Human1.14488859
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11740978
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11704394
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11618790
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11395213
103ZNF263_19887448_ChIP-Seq_K562_Human1.09478215
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09190189
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08885929
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08496266
107CHD1_26751641_Chip-Seq_LNCaP_Human1.07043472
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06565712
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05733799
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05647637
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05632463
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05548797
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05137895
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.02603733
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02486531
116VDR_24787735_ChIP-Seq_THP-1_Human1.01602973
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00517832
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00116731
119GATA3_27048872_Chip-Seq_THYMUS_Human0.99270521
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99159151
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98958291
122* RUNX1_22412390_ChIP-Seq_EML_Mouse0.98833491
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98642253
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97848570
125* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96644004
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.96613488
127TP63_19390658_ChIP-ChIP_HaCaT_Human0.95674804
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93677780
129MAF_26560356_Chip-Seq_TH1_Human0.91408009
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90981278
131* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90593990
132* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89804294
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89166964
134SRF_21415370_ChIP-Seq_HL-1_Mouse0.89080627
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88762644
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88693997
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88494411
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87365245
139ER_23166858_ChIP-Seq_MCF-7_Human0.87095345
140EWS_26573619_Chip-Seq_HEK293_Human0.85982459
141SCL_19346495_ChIP-Seq_HPC-7_Human0.85968561
142GATA3_26560356_Chip-Seq_TH1_Human0.85574631
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84556962
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83826334
145RUNX_20019798_ChIP-Seq_JUKART_Human0.83276545
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82041653
147SPI1_23127762_ChIP-Seq_K562_Human0.81572284
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.76753022
149* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75955312
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75281800
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74638980
152VDR_21846776_ChIP-Seq_THP-1_Human0.73943152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.93349782
2MP0003111_abnormal_nucleus_morphology3.90248087
3MP0010094_abnormal_chromosome_stability3.62534385
4MP0004957_abnormal_blastocyst_morpholog3.60882506
5MP0008057_abnormal_DNA_replication3.33678042
6MP0003806_abnormal_nucleotide_metabolis3.20826312
7MP0003077_abnormal_cell_cycle3.20773703
8MP0001730_embryonic_growth_arrest2.81983804
9MP0010352_gastrointestinal_tract_polyps2.77485463
10MP0003646_muscle_fatigue2.75779366
11MP0008932_abnormal_embryonic_tissue2.70346631
12MP0003705_abnormal_hypodermis_morpholog2.64689960
13MP0003172_abnormal_lysosome_physiology2.53820097
14MP0000569_abnormal_digit_pigmentation2.52480805
15MP0000685_abnormal_immune_system2.47424135
16MP0001835_abnormal_antigen_presentation2.46986337
17MP0003123_paternal_imprinting2.46659827
18MP0005451_abnormal_body_composition2.43769979
19MP0008007_abnormal_cellular_replicative2.42447593
20MP0002009_preneoplasia2.29767017
21MP0000350_abnormal_cell_proliferation2.14620466
22MP0010030_abnormal_orbit_morphology2.09899829
23MP0005058_abnormal_lysosome_morphology1.97178050
24MP0001672_abnormal_embryogenesis/_devel1.95627435
25MP0005380_embryogenesis_phenotype1.95627435
26MP0004197_abnormal_fetal_growth/weight/1.93687026
27MP0008438_abnormal_cutaneous_collagen1.90138993
28MP0001697_abnormal_embryo_size1.88492676
29MP0005310_abnormal_salivary_gland1.86918714
30MP0001293_anophthalmia1.86372657
31MP0002085_abnormal_embryonic_tissue1.79978209
32MP0003984_embryonic_growth_retardation1.78914236
33MP0003950_abnormal_plasma_membrane1.78675397
34MP0002088_abnormal_embryonic_growth/wei1.75031432
35MP0002080_prenatal_lethality1.73477124
36MP0002084_abnormal_developmental_patter1.72855471
37MP0008058_abnormal_DNA_repair1.72019856
38MP0010307_abnormal_tumor_latency1.69517096
39MP0005671_abnormal_response_to1.68588819
40MP0003937_abnormal_limbs/digits/tail_de1.67203040
41MP0002396_abnormal_hematopoietic_system1.65349501
42MP0003567_abnormal_fetal_cardiomyocyte1.63837819
43MP0003763_abnormal_thymus_physiology1.62074196
44MP0003718_maternal_effect1.60972074
45MP0000733_abnormal_muscle_development1.58649571
46MP0002086_abnormal_extraembryonic_tissu1.58094794
47MP0000371_diluted_coat_color1.56721592
48MP0002419_abnormal_innate_immunity1.54683181
49MP0000537_abnormal_urethra_morphology1.53956111
50MP0010234_abnormal_vibrissa_follicle1.53310875
51MP0000747_muscle_weakness1.50807530
52MP0006035_abnormal_mitochondrial_morpho1.50506412
53MP0002166_altered_tumor_susceptibility1.48751523
54MP0005410_abnormal_fertilization1.48373624
55MP0002452_abnormal_antigen_presenting1.47135895
56MP0001800_abnormal_humoral_immune1.46187356
57MP0000015_abnormal_ear_pigmentation1.45339968
58MP0002877_abnormal_melanocyte_morpholog1.41891756
59MP0003300_gastrointestinal_ulcer1.40936855
60MP0000428_abnormal_craniofacial_morphol1.40829950
61MP0005379_endocrine/exocrine_gland_phen1.40707926
62MP0005387_immune_system_phenotype1.37478057
63MP0001790_abnormal_immune_system1.37478057
64MP0002723_abnormal_immune_serum1.33077119
65MP0002420_abnormal_adaptive_immunity1.27483345
66MP0001819_abnormal_immune_cell1.26969568
67MP0003786_premature_aging1.25705150
68MP0002405_respiratory_system_inflammati1.23998557
69MP0003890_abnormal_embryonic-extraembry1.21777542
70MP0003221_abnormal_cardiomyocyte_apopto1.21379091
71MP0000427_abnormal_hair_cycle1.21081488
72MP0005623_abnormal_meninges_morphology1.20818561
73MP0009785_altered_susceptibility_to1.19883363
74MP0003195_calcinosis1.18680421
75MP0002092_abnormal_eye_morphology1.18566666
76MP0009672_abnormal_birth_weight1.17848190
77MP0002398_abnormal_bone_marrow1.17074662
78MP0000689_abnormal_spleen_morphology1.15382146
79MP0003436_decreased_susceptibility_to1.14158596
80MP0002111_abnormal_tail_morphology1.13296729
81MP0000750_abnormal_muscle_regeneration1.11736993
82MP0005000_abnormal_immune_tolerance1.11666138
83MP0002269_muscular_atrophy1.11570456
84MP0000703_abnormal_thymus_morphology1.11539404
85MP0003656_abnormal_erythrocyte_physiolo1.09613432
86MP0008877_abnormal_DNA_methylation1.08511289
87MP0005365_abnormal_bile_salt1.07874879
88MP0009703_decreased_birth_body1.07080369
89MP0001915_intracranial_hemorrhage1.06203584
90MP0000716_abnormal_immune_system1.05892480
91MP0000313_abnormal_cell_death1.05007566
92MP0002148_abnormal_hypersensitivity_rea1.04699198
93MP0005464_abnormal_platelet_physiology1.04582513
94MP0003252_abnormal_bile_duct1.03603044
95MP0002722_abnormal_immune_system1.03292655
96MP0005025_abnormal_response_to1.00691272
97MP0004185_abnormal_adipocyte_glucose0.99034393
98MP0002006_tumorigenesis0.98487398
99MP0009840_abnormal_foam_cell0.97218037
100MP0001661_extended_life_span0.97144020
101MP0009333_abnormal_splenocyte_physiolog0.97100442
102MP0002429_abnormal_blood_cell0.96467483
103MP0003121_genomic_imprinting0.95466166
104MP0009053_abnormal_anal_canal0.95259118
105MP0003566_abnormal_cell_adhesion0.95012212
106MP0000358_abnormal_cell_content/0.94910216
107MP0005076_abnormal_cell_differentiation0.91714401
108MP0002019_abnormal_tumor_incidence0.91681984
109MP0009697_abnormal_copulation0.90886878
110MP0005266_abnormal_metabolism0.89576976
111MP0000377_abnormal_hair_follicle0.89322930
112MP0005023_abnormal_wound_healing0.88239842
113MP0001299_abnormal_eye_distance/0.87893551
114MP0003828_pulmonary_edema0.87740687
115MP0003755_abnormal_palate_morphology0.87470205
116MP0005384_cellular_phenotype0.85629524
117MP0000609_abnormal_liver_physiology0.84895164
118MP0001845_abnormal_inflammatory_respons0.83495038
119MP0005621_abnormal_cell_physiology0.83044987
120MP0000647_abnormal_sebaceous_gland0.82060414
121MP0000383_abnormal_hair_follicle0.81544489
122MP0002138_abnormal_hepatobiliary_system0.81365443
123MP0000432_abnormal_head_morphology0.80641436
124MP0001243_abnormal_dermal_layer0.80213040
125MP0005647_abnormal_sex_gland0.79509258
126MP0002139_abnormal_hepatobiliary_system0.78748232
127MP0008469_abnormal_protein_level0.78279456
128MP0004133_heterotaxia0.77835866
129MP0010678_abnormal_skin_adnexa0.77608906
130MP0002160_abnormal_reproductive_system0.77056702
131MP0000920_abnormal_myelination0.76870135
132MP0002114_abnormal_axial_skeleton0.76744122
133MP0001286_abnormal_eye_development0.76434234
134MP0005409_darkened_coat_color0.76159691
135MP0003935_abnormal_craniofacial_develop0.76065811
136MP0002938_white_spotting0.75821890
137MP0001186_pigmentation_phenotype0.75800381
138MP0005174_abnormal_tail_pigmentation0.75271474
139MP0004808_abnormal_hematopoietic_stem0.74431683
140MP0008770_decreased_survivor_rate0.73022811
141MP0003943_abnormal_hepatobiliary_system0.72467876
142MP0003861_abnormal_nervous_system0.71565206
143MP0001849_ear_inflammation0.71546748
144MP0001145_abnormal_male_reproductive0.71487583
145MP0003191_abnormal_cellular_cholesterol0.71399964
146MP0004134_abnormal_chest_morphology0.70420424
147MP0000490_abnormal_crypts_of0.70386136
148MP0003119_abnormal_digestive_system0.70155270
149MP0001727_abnormal_embryo_implantation0.70106579
150MP0004233_abnormal_muscle_weight0.70053691
151MP0005389_reproductive_system_phenotype0.70026291
152MP0000462_abnormal_digestive_system0.69445743
153MP0003938_abnormal_ear_development0.68617953
154MP0002210_abnormal_sex_determination0.68518263
155MP0002697_abnormal_eye_size0.66818823
156MP0003942_abnormal_urinary_system0.65422017
157MP0002925_abnormal_cardiovascular_devel0.64875710
158MP0000762_abnormal_tongue_morphology0.64100407
159MP0000759_abnormal_skeletal_muscle0.63860980
160MP0005330_cardiomyopathy0.62794297
161MP0002075_abnormal_coat/hair_pigmentati0.61617997
162MP0004087_abnormal_muscle_fiber0.60378325

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.84521035
2Birth length less than 3rd percentile (HP:0003561)4.15409282
3Recurrent bacterial skin infections (HP:0005406)3.85809350
4Ependymoma (HP:0002888)3.53343726
5Abnormality of the labia minora (HP:0012880)3.44930254
6Abnormality of glycolipid metabolism (HP:0010969)3.30255865
7Abnormality of liposaccharide metabolism (HP:0010968)3.30255865
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.30255865
9Increased cerebral lipofuscin (HP:0011813)3.22452611
10Recurrent abscess formation (HP:0002722)3.21977793
11Selective tooth agenesis (HP:0001592)3.20716499
12Breast hypoplasia (HP:0003187)3.16647194
13Premature rupture of membranes (HP:0001788)3.16057207
14Microvesicular hepatic steatosis (HP:0001414)3.14272773
15Stenosis of the external auditory canal (HP:0000402)3.10649713
16Increased neuronal autofluorescent lipopigment (HP:0002074)2.98401805
17Eczematoid dermatitis (HP:0000976)2.84072245
18CNS hypomyelination (HP:0003429)2.81238125
19Recurrent fungal infections (HP:0002841)2.80363656
20Progressive muscle weakness (HP:0003323)2.78348342
21Recurrent viral infections (HP:0004429)2.72375285
22Recurrent cutaneous fungal infections (HP:0011370)2.67278116
23Chronic mucocutaneous candidiasis (HP:0002728)2.67278116
24Astrocytoma (HP:0009592)2.65494663
25Abnormality of the astrocytes (HP:0100707)2.65494663
26Recurrent skin infections (HP:0001581)2.64543687
27Megaloblastic anemia (HP:0001889)2.63362667
28Vacuolated lymphocytes (HP:0001922)2.61894844
29Abnormality of T cell physiology (HP:0011840)2.59752810
30Nemaline bodies (HP:0003798)2.58941682
31T lymphocytopenia (HP:0005403)2.56707197
32Abnormality of DNA repair (HP:0003254)2.55725330
33Progressive inability to walk (HP:0002505)2.54293888
34Homocystinuria (HP:0002156)2.52771535
35Abnormality of homocysteine metabolism (HP:0010919)2.52771535
36Basal cell carcinoma (HP:0002671)2.50883993
37Abnormality of T cell number (HP:0011839)2.49288883
38Medulloblastoma (HP:0002885)2.49210190
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48099819
40Abnormality of the pons (HP:0007361)2.46203952
41Abnormality of the calcaneus (HP:0008364)2.45183311
42Abnormality of the umbilical cord (HP:0010881)2.45016774
43Stomatitis (HP:0010280)2.42634599
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42311820
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.42311820
46Abnormality of macrophages (HP:0004311)2.42026277
47Autoimmune thrombocytopenia (HP:0001973)2.42021889
48Fair hair (HP:0002286)2.40977926
49Glioma (HP:0009733)2.37167065
50Absent radius (HP:0003974)2.37132982
51Postnatal microcephaly (HP:0005484)2.36203549
52Myocardial infarction (HP:0001658)2.35777802
53Muscle fiber inclusion bodies (HP:0100299)2.31768973
54Abnormality of T cells (HP:0002843)2.30574309
55Abnormality of cells of the erythroid lineage (HP:0012130)2.30222945
56Squamous cell carcinoma (HP:0002860)2.27287675
57Rough bone trabeculation (HP:0100670)2.26055450
58Glossoptosis (HP:0000162)2.26002277
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.25736411
60Mediastinal lymphadenopathy (HP:0100721)2.25129645
61Optic neuritis (HP:0100653)2.24573992
62Retrobulbar optic neuritis (HP:0100654)2.24573992
63Prostate neoplasm (HP:0100787)2.24336028
64Sparse lateral eyebrow (HP:0005338)2.22441824
65Trismus (HP:0000211)2.20924158
66Hypoplasia of the pons (HP:0012110)2.20745986
67Absent forearm bone (HP:0003953)2.19745662
68Aplasia involving forearm bones (HP:0009822)2.19745662
69Cutaneous melanoma (HP:0012056)2.19278587
70Abnormality of glycolysis (HP:0004366)2.15836828
71Increased serum pyruvate (HP:0003542)2.15836828
72Entropion (HP:0000621)2.14930892
73Rhabdomyosarcoma (HP:0002859)2.14730743
74Calcaneovalgus deformity (HP:0001848)2.14538184
75Chromsome breakage (HP:0040012)2.13305514
76Carpal bone hypoplasia (HP:0001498)2.12920988
77Pelvic girdle muscle weakness (HP:0003749)2.11281225
78Ureteral duplication (HP:0000073)2.11026908
79Abnormality of the preputium (HP:0100587)2.10289654
80Hypobetalipoproteinemia (HP:0003563)2.09811621
81Deviation of the thumb (HP:0009603)2.09708763
82Protruding tongue (HP:0010808)2.09221659
83Ankle contracture (HP:0006466)2.09016814
84Myositis (HP:0100614)2.08910949
85Proximal placement of thumb (HP:0009623)2.05106812
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04660822
87Hyperglycinemia (HP:0002154)2.01903581
88Pancreatic islet-cell hyperplasia (HP:0004510)2.01875606
89Atresia of the external auditory canal (HP:0000413)2.01723890
90Abnormality of the ileum (HP:0001549)2.01273218
91Duplicated collecting system (HP:0000081)2.01119990
92Recurrent gram-negative bacterial infections (HP:0005420)2.01012440
93Orchitis (HP:0100796)2.00405323
94IgA deficiency (HP:0002720)2.00340116
95Impulsivity (HP:0100710)1.98411039
96Deformed tarsal bones (HP:0008119)1.98157463
97Macrocytic anemia (HP:0001972)1.97462169
98Abnormal number of incisors (HP:0011064)1.96719151
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.96164503
100Shoulder girdle muscle weakness (HP:0003547)1.95764224
101Cheilitis (HP:0100825)1.94627711
102Dysmetric saccades (HP:0000641)1.94214364
103Achilles tendon contracture (HP:0001771)1.93885051
104Slender long bone (HP:0003100)1.93581033
105Abnormality of the musculature of the pelvis (HP:0001469)1.93415421
106Abnormality of the hip-girdle musculature (HP:0001445)1.93415421
107Fused cervical vertebrae (HP:0002949)1.91435421
108Oral leukoplakia (HP:0002745)1.91024776
109Neoplasm of the oral cavity (HP:0100649)1.90785311
110Insidious onset (HP:0003587)1.90434636
111Termporal pattern (HP:0011008)1.90434636
112Tinnitus (HP:0000360)1.89427622
113Clumsiness (HP:0002312)1.89358783
114Pustule (HP:0200039)1.87903134
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87381321
116Abnormality of transition element cation homeostasis (HP:0011030)1.87132171
117Clubbing of toes (HP:0100760)1.87016947
118Frequent falls (HP:0002359)1.86998167
119Sensory axonal neuropathy (HP:0003390)1.86816464
120Overriding aorta (HP:0002623)1.86398694
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86241239
122Hematochezia (HP:0002573)1.85575725
123Patellar aplasia (HP:0006443)1.85421586
124Submucous cleft hard palate (HP:0000176)1.85168947
125Combined immunodeficiency (HP:0005387)1.85078632
126Abnormality of alanine metabolism (HP:0010916)1.84543561
127Hyperalaninemia (HP:0003348)1.84543561
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84543561
129Ulnar bowing (HP:0003031)1.82566373
130Shallow orbits (HP:0000586)1.82467795
131Upper motor neuron abnormality (HP:0002127)1.82242156
132Abnormal biliary tract morphology (HP:0012440)1.81873341
133Acute myeloid leukemia (HP:0004808)1.81249711
134Agnosia (HP:0010524)1.80146847
135Capillary hemangiomas (HP:0005306)1.79678434
136Meckel diverticulum (HP:0002245)1.79393128
137Aplasia/hypoplasia of the humerus (HP:0006507)1.79197121
138Arterial thrombosis (HP:0004420)1.79172217
139Type II lissencephaly (HP:0007260)1.78778085
140Abnormality of the Achilles tendon (HP:0005109)1.77511107
141IgG deficiency (HP:0004315)1.77211550
142Gaze-evoked nystagmus (HP:0000640)1.77030800
143Aplasia/Hypoplasia of the patella (HP:0006498)1.76997497
144Horseshoe kidney (HP:0000085)1.74632315
145Biliary tract neoplasm (HP:0100574)1.74292355
146Colon cancer (HP:0003003)1.73778567
147Osteolytic defects of the hand bones (HP:0009699)1.73760217
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.73760217
149Abnormality of serum amino acid levels (HP:0003112)1.72045337
150Prominent occiput (HP:0000269)1.71836054
151Abnormal spermatogenesis (HP:0008669)1.71811932
152Conjunctival telangiectasia (HP:0000524)1.71806819
153Neoplasm of striated muscle (HP:0009728)1.71696611
154Short chin (HP:0000331)1.71646432
155Neoplasm of the pancreas (HP:0002894)1.71554171
156Protrusio acetabuli (HP:0003179)1.70906041
157Difficulty climbing stairs (HP:0003551)1.70887624
158Viral hepatitis (HP:0006562)1.70341627
159Abnormalities of placenta or umbilical cord (HP:0001194)1.70163640
160Asplenia (HP:0001746)1.69999043
161Abnormality of the renal collecting system (HP:0004742)1.68812644
162Gastrointestinal infarctions (HP:0005244)1.68643544
163Gingivitis (HP:0000230)1.67962285
164Secondary amenorrhea (HP:0000869)1.67513709
165Obstructive lung disease (HP:0006536)1.67359549
166Chronic obstructive pulmonary disease (HP:0006510)1.67359549
167Generalized hypopigmentation of hair (HP:0011358)1.67283294
168Hemoptysis (HP:0002105)1.67014672
169Poikiloderma (HP:0001029)1.66930935
170Abnormality of methionine metabolism (HP:0010901)1.66641428
171Abnormality of chromosome stability (HP:0003220)1.65697235
172Aplasia/Hypoplasia of the spleen (HP:0010451)1.65407070
173Premature graying of hair (HP:0002216)1.65229422
174Abnormality of the prostate (HP:0008775)1.65204188
175Prominent nose (HP:0000448)1.65180977
176Azoospermia (HP:0000027)1.65003727
177Muscle fiber splitting (HP:0003555)1.64453290
178Subacute progressive viral hepatitis (HP:0006572)1.64299890
179Pseudobulbar signs (HP:0002200)1.63980478
180Stillbirth (HP:0003826)1.63912463
181Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63641288
182Increased serum ferritin (HP:0003281)1.63573165
183Abnormality of pyrimidine metabolism (HP:0004353)1.62923559
184Abnormality of chromosome segregation (HP:0002916)1.62902466
185Autoamputation (HP:0001218)1.62362081
186Short palpebral fissure (HP:0012745)1.61374329
187Multiple enchondromatosis (HP:0005701)1.61230770
188Abnormality of the corticospinal tract (HP:0002492)1.61101009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59673787
2FRK3.49926722
3CDC73.49479906
4WEE13.44820216
5EIF2AK13.07395700
6TSSK62.76960709
7CAMK1D2.55459041
8MAP3K142.35398965
9RPS6KB22.26395927
10MKNK12.25822062
11CAMK1G2.24710572
12TTK2.09653233
13CDK122.05275844
14IRAK31.97118451
15TESK21.88078721
16EEF2K1.85566226
17MAP3K131.84764072
18EPHA21.84449668
19ALK1.82001402
20MKNK21.79122928
21TLK11.75486504
22BRSK21.73571241
23NEK21.66446027
24SRPK11.66108724
25BLK1.64514096
26EIF2AK31.63630685
27NEK11.63193430
28MAP3K81.62765339
29LATS11.59303080
30CDK71.56766256
31PLK41.54699695
32MET1.52790334
33CAMKK21.52593147
34PLK11.50568943
35STK101.49346723
36IRAK41.47391674
37PINK11.45201766
38TAOK31.40171514
39TTN1.40119071
40BRD41.38224642
41PLK31.36573202
42PKN21.33458538
43PASK1.31891441
44MAPK111.31737126
45CDK41.30604951
46ZAK1.27380539
47CHEK11.23239843
48PAK21.22047432
49FGFR31.21005270
50SMG11.20926696
51LIMK11.20529201
52ADRBK21.20184374
53FLT31.19403188
54TEC1.18970543
55ATR1.17862797
56NUAK11.16193669
57SCYL21.14213527
58MARK31.14209186
59VRK11.11734666
60PNCK1.11508965
61TAF11.11342619
62FGFR21.11066481
63STK391.10769733
64CHEK21.09681478
65MAP3K101.08526848
66LATS21.07347132
67AURKA1.06146731
68NME21.04275255
69AURKB1.03958833
70PAK11.01320076
71MAPKAPK30.97677268
72IRAK10.96870704
73PDK20.96703515
74BRSK10.96439793
75STK30.92697028
76PRKAA20.91934830
77BMPR1B0.90778158
78STK160.90613490
79OBSCN0.88705265
80MAP4K20.87407551
81IKBKB0.86957527
82MTOR0.85957829
83DYRK30.85734449
84NEK90.84630360
85CSNK1A1L0.84399186
86PDPK10.84023207
87CDK20.82662129
88CSK0.82225535
89INSRR0.81177220
90PDK10.81031357
91TGFBR20.80102158
92FGFR10.78995528
93CSNK1E0.75661578
94CSNK1G30.74007974
95RPS6KA40.73879650
96MELK0.72705622
97ATM0.71420344
98TYK20.71381688
99FGR0.71104834
100ROCK20.69725238
101DDR20.69613811
102ICK0.68547310
103ACVR1B0.68176213
104MAP3K90.68141432
105ITK0.67850292
106BTK0.66426660
107STK38L0.66423593
108PAK40.66342741
109CDK10.65477598
110TAOK20.63846353
111CSNK2A20.63579438
112AKT30.62122576
113LRRK20.61976266
114BMX0.61066858
115MAP4K10.60314083
116JAK30.59940823
117TRIB30.58667166
118ILK0.56917129
119CSNK1G10.56643658
120TRPM70.56356331
121RPS6KB10.56217776
122OXSR10.56197497
123CSNK1D0.53181737
124PIK3CG0.52563230
125RPS6KA50.51884309
126TXK0.51865178
127CDK60.51462067
128CLK10.51414045
129FES0.49735348
130PRKAA10.49398035
131MAP2K60.49246564
132STK40.47982114
133LYN0.47766793
134BCKDK0.47117837
135ERBB30.46484935
136CSF1R0.46298690
137ZAP700.46062325
138FGFR40.45970371
139MAP2K30.45113373
140CDK190.44971544
141MAP2K40.44963014
142JAK10.44893543
143PBK0.44132957
144SYK0.42693450
145TYRO30.42140381
146RPS6KA10.39357913
147PRKCI0.39266984
148EPHB10.38452683
149CDK140.37218494
150CDK11A0.36504117
151CDK150.36217037
152PRKDC0.36096366
153CSNK2A10.33860327
154PDGFRA0.33235535
155MOS0.33164783
156AKT20.32622357

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18592932
2DNA replication_Homo sapiens_hsa030303.96848764
3One carbon pool by folate_Homo sapiens_hsa006703.66196251
4Mismatch repair_Homo sapiens_hsa034303.47130652
5RNA transport_Homo sapiens_hsa030133.22612604
6RNA polymerase_Homo sapiens_hsa030203.03083887
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.99531975
8Spliceosome_Homo sapiens_hsa030402.86480369
9Proteasome_Homo sapiens_hsa030502.53369374
10Cell cycle_Homo sapiens_hsa041102.53060479
11Vitamin B6 metabolism_Homo sapiens_hsa007502.48588483
12Other glycan degradation_Homo sapiens_hsa005112.30116617
13Nucleotide excision repair_Homo sapiens_hsa034202.26291395
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24549553
15Ribosome_Homo sapiens_hsa030102.14728386
16Base excision repair_Homo sapiens_hsa034102.12807513
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07290879
18Homologous recombination_Homo sapiens_hsa034402.06122508
19Lysosome_Homo sapiens_hsa041421.92482876
20Pyrimidine metabolism_Homo sapiens_hsa002401.87864046
21Biosynthesis of amino acids_Homo sapiens_hsa012301.86779433
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81171624
23Systemic lupus erythematosus_Homo sapiens_hsa053221.75492122
24Fanconi anemia pathway_Homo sapiens_hsa034601.60450833
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.59055627
26Folate biosynthesis_Homo sapiens_hsa007901.58108901
27B cell receptor signaling pathway_Homo sapiens_hsa046621.51969648
28mRNA surveillance pathway_Homo sapiens_hsa030151.47409842
29Basal transcription factors_Homo sapiens_hsa030221.40133867
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39962990
31Non-homologous end-joining_Homo sapiens_hsa034501.39947821
32Osteoclast differentiation_Homo sapiens_hsa043801.37529390
33RNA degradation_Homo sapiens_hsa030181.36480969
34Staphylococcus aureus infection_Homo sapiens_hsa051501.32352536
35Steroid biosynthesis_Homo sapiens_hsa001001.30944484
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.27565592
37Selenocompound metabolism_Homo sapiens_hsa004501.27559617
38p53 signaling pathway_Homo sapiens_hsa041151.23707127
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23618377
40T cell receptor signaling pathway_Homo sapiens_hsa046601.21013036
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18697155
42Tuberculosis_Homo sapiens_hsa051521.18047446
43Pentose phosphate pathway_Homo sapiens_hsa000301.16684025
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.16569707
45Viral carcinogenesis_Homo sapiens_hsa052031.16367710
46Leishmaniasis_Homo sapiens_hsa051401.13043065
47Primary immunodeficiency_Homo sapiens_hsa053401.10012885
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06193613
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05552473
50Sulfur metabolism_Homo sapiens_hsa009201.05078178
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04745085
52Purine metabolism_Homo sapiens_hsa002301.03014107
53Arginine and proline metabolism_Homo sapiens_hsa003300.99112143
54Insulin resistance_Homo sapiens_hsa049310.97849032
55Carbon metabolism_Homo sapiens_hsa012000.97532575
56Sulfur relay system_Homo sapiens_hsa041220.97461264
57Measles_Homo sapiens_hsa051620.95779636
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.95375800
59Dorso-ventral axis formation_Homo sapiens_hsa043200.95023363
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94044452
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93671454
62Pancreatic cancer_Homo sapiens_hsa052120.91811808
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91500468
64Legionellosis_Homo sapiens_hsa051340.89085556
65Hepatitis B_Homo sapiens_hsa051610.88980772
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87855307
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87084139
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.86781782
69Graft-versus-host disease_Homo sapiens_hsa053320.85990151
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85722531
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.84077097
72MicroRNAs in cancer_Homo sapiens_hsa052060.83196404
73Epstein-Barr virus infection_Homo sapiens_hsa051690.83195345
74Toxoplasmosis_Homo sapiens_hsa051450.81962429
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79811362
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79471387
77Ether lipid metabolism_Homo sapiens_hsa005650.79117524
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76527243
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.75944884
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.75194473
81TNF signaling pathway_Homo sapiens_hsa046680.72394823
82Apoptosis_Homo sapiens_hsa042100.71279880
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69914764
84FoxO signaling pathway_Homo sapiens_hsa040680.68917257
85Influenza A_Homo sapiens_hsa051640.68529299
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68062546
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.66226529
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65644029
89Phagosome_Homo sapiens_hsa041450.64965178
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64912067
91Oocyte meiosis_Homo sapiens_hsa041140.64409966
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64368047
93Sphingolipid metabolism_Homo sapiens_hsa006000.62062120
94Glutathione metabolism_Homo sapiens_hsa004800.60753508
95Alcoholism_Homo sapiens_hsa050340.60080520
96Allograft rejection_Homo sapiens_hsa053300.58130120
97Platelet activation_Homo sapiens_hsa046110.57021976
98Thyroid cancer_Homo sapiens_hsa052160.54922895
99Hippo signaling pathway_Homo sapiens_hsa043900.54721498
100Bladder cancer_Homo sapiens_hsa052190.54638839
101Renal cell carcinoma_Homo sapiens_hsa052110.53773929
102Fatty acid elongation_Homo sapiens_hsa000620.53089093
103Prolactin signaling pathway_Homo sapiens_hsa049170.52326242
104Small cell lung cancer_Homo sapiens_hsa052220.52102146
105HTLV-I infection_Homo sapiens_hsa051660.51978195
106Basal cell carcinoma_Homo sapiens_hsa052170.51805623
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51617860
108Type I diabetes mellitus_Homo sapiens_hsa049400.50880645
109Hedgehog signaling pathway_Homo sapiens_hsa043400.50103961
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.49519479
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48773477
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47046991
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46127896
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.45402041
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45192354
116Hematopoietic cell lineage_Homo sapiens_hsa046400.44638947
117Vitamin digestion and absorption_Homo sapiens_hsa049770.44483196
118Autoimmune thyroid disease_Homo sapiens_hsa053200.44280829
119Lysine degradation_Homo sapiens_hsa003100.43513186
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43365230
121N-Glycan biosynthesis_Homo sapiens_hsa005100.43278825
122ABC transporters_Homo sapiens_hsa020100.42059387
123Viral myocarditis_Homo sapiens_hsa054160.40755434
124Inositol phosphate metabolism_Homo sapiens_hsa005620.40667637
125Tight junction_Homo sapiens_hsa045300.40525357
126Nitrogen metabolism_Homo sapiens_hsa009100.40474811
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39261948
128TGF-beta signaling pathway_Homo sapiens_hsa043500.39048107
129Fatty acid biosynthesis_Homo sapiens_hsa000610.38606371
130Proteoglycans in cancer_Homo sapiens_hsa052050.37712407
131Prostate cancer_Homo sapiens_hsa052150.35870481
132mTOR signaling pathway_Homo sapiens_hsa041500.34206667
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34132410
134Chronic myeloid leukemia_Homo sapiens_hsa052200.33635179
135Antigen processing and presentation_Homo sapiens_hsa046120.33325402
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32316020
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32012339
138Metabolic pathways_Homo sapiens_hsa011000.29762759
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29537405
140Fatty acid metabolism_Homo sapiens_hsa012120.28832481
141Non-small cell lung cancer_Homo sapiens_hsa052230.28779901
142Shigellosis_Homo sapiens_hsa051310.27012189
143Pathways in cancer_Homo sapiens_hsa052000.20651682
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19625429
145Protein export_Homo sapiens_hsa030600.18396357
146ECM-receptor interaction_Homo sapiens_hsa045120.17920113
147Notch signaling pathway_Homo sapiens_hsa043300.17858967
148HIF-1 signaling pathway_Homo sapiens_hsa040660.17651989
149Wnt signaling pathway_Homo sapiens_hsa043100.17426102
150Acute myeloid leukemia_Homo sapiens_hsa052210.15869965
151Herpes simplex infection_Homo sapiens_hsa051680.15862815
152Arginine biosynthesis_Homo sapiens_hsa002200.15480989
153Focal adhesion_Homo sapiens_hsa045100.15090220
154Propanoate metabolism_Homo sapiens_hsa006400.12650639
155Pyruvate metabolism_Homo sapiens_hsa006200.12556599
156Colorectal cancer_Homo sapiens_hsa052100.12428607

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