HEATR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.95342616
2epithelial cilium movement (GO:0003351)9.71438508
3reproduction (GO:0000003)9.67748316
4spermatid development (GO:0007286)9.30945762
5motile cilium assembly (GO:0044458)9.13665410
6regulation of cilium movement (GO:0003352)8.44692272
7cilium movement (GO:0003341)8.07738779
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.71596806
9single fertilization (GO:0007338)7.62258308
10piRNA metabolic process (GO:0034587)7.55822071
11male meiosis (GO:0007140)7.46418783
12synaptonemal complex organization (GO:0070193)7.15367722
13sperm capacitation (GO:0048240)7.12287793
14synaptonemal complex assembly (GO:0007130)7.08820294
15microtubule depolymerization (GO:0007019)6.43149943
16fertilization (GO:0009566)6.38592609
17spermatogenesis (GO:0007283)6.30839168
18male gamete generation (GO:0048232)6.28607732
19negative regulation of inclusion body assembly (GO:0090084)6.01459849
20organic cation transport (GO:0015695)5.90189539
21gamete generation (GO:0007276)5.78689289
22response to pheromone (GO:0019236)5.71995983
23ventricular system development (GO:0021591)5.34851008
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.33343883
25germ cell development (GO:0007281)5.21862926
26calcium ion-dependent exocytosis (GO:0017156)5.17360419
27chromosome organization involved in meiosis (GO:0070192)5.04384009
28regulation of inclusion body assembly (GO:0090083)5.03601703
29cell recognition (GO:0008037)5.03112191
30DNA methylation involved in gamete generation (GO:0043046)4.97056188
31male meiosis I (GO:0007141)4.97054977
32regulation of microtubule-based movement (GO:0060632)4.82565767
33spermatid nucleus differentiation (GO:0007289)4.80693937
34microtubule severing (GO:0051013)4.76578916
35multicellular organismal reproductive process (GO:0048609)4.55629408
36seminiferous tubule development (GO:0072520)4.50277201
37meiotic nuclear division (GO:0007126)4.44992696
38glycerol ether metabolic process (GO:0006662)4.44696075
39chromosome condensation (GO:0030261)4.43455414
40L-fucose catabolic process (GO:0042355)4.34604105
41fucose catabolic process (GO:0019317)4.34604105
42L-fucose metabolic process (GO:0042354)4.34604105
43DNA packaging (GO:0006323)4.23126170
44ether metabolic process (GO:0018904)4.10335018
45regulation of meiosis I (GO:0060631)4.04191547
46neural tube formation (GO:0001841)3.98757463
47meiosis I (GO:0007127)3.98272134
48left/right pattern formation (GO:0060972)3.97897958
49behavioral response to nicotine (GO:0035095)3.86667311
50monoubiquitinated protein deubiquitination (GO:0035520)3.86512848
51chaperone-mediated protein complex assembly (GO:0051131)3.83021458
52tachykinin receptor signaling pathway (GO:0007217)3.80701176
53protein polyglutamylation (GO:0018095)3.69809968
54adaptation of signaling pathway (GO:0023058)3.69148848
55multicellular organismal development (GO:0007275)3.67771300
56negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.60074036
57genitalia morphogenesis (GO:0035112)3.58938928
58tryptophan catabolic process (GO:0006569)3.50825747
59indole-containing compound catabolic process (GO:0042436)3.50825747
60indolalkylamine catabolic process (GO:0046218)3.50825747
61meiotic cell cycle (GO:0051321)3.47474806
62cellular ketone body metabolic process (GO:0046950)3.45827393
63GTP biosynthetic process (GO:0006183)3.44956833
64regulation of spindle checkpoint (GO:0090231)3.43387457
65single strand break repair (GO:0000012)3.41069488
66indolalkylamine metabolic process (GO:0006586)3.40576965
67protein localization to cilium (GO:0061512)3.32614517
68microtubule polymerization or depolymerization (GO:0031109)3.31100816
69detection of light stimulus involved in sensory perception (GO:0050962)3.30621040
70detection of light stimulus involved in visual perception (GO:0050908)3.30621040
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27634849
72synapsis (GO:0007129)3.24938353
73DNA deamination (GO:0045006)3.23541073
74nucleoside diphosphate phosphorylation (GO:0006165)3.22129794
75sequestering of actin monomers (GO:0042989)3.20737473
76protein K11-linked deubiquitination (GO:0035871)3.20581462
77pyrimidine nucleobase catabolic process (GO:0006208)3.18355744
78sphingoid metabolic process (GO:0046519)3.15553744
79positive regulation of meiosis (GO:0045836)3.14948952
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13957199
81UTP biosynthetic process (GO:0006228)3.08053177
82ketone body metabolic process (GO:1902224)3.07199373
83sphingosine metabolic process (GO:0006670)3.06864142
84regulation of centriole replication (GO:0046599)3.05616130
85carnitine transport (GO:0015879)3.03174897
86amino-acid betaine transport (GO:0015838)3.03174897
87serotonin receptor signaling pathway (GO:0007210)3.00612887
88meiotic cell cycle process (GO:1903046)3.00500961
89polyol catabolic process (GO:0046174)3.00344151
90inositol phosphate catabolic process (GO:0071545)2.98548823
91diol metabolic process (GO:0034311)2.98435073
92interferon-gamma secretion (GO:0072643)2.97871915
93regulation of hexokinase activity (GO:1903299)2.97315646
94regulation of glucokinase activity (GO:0033131)2.97315646
95gene silencing by RNA (GO:0031047)2.96908470
96kynurenine metabolic process (GO:0070189)2.96356667
97positive regulation of meiotic cell cycle (GO:0051446)2.96178321
98protein refolding (GO:0042026)2.94860212
99nucleus organization (GO:0006997)2.93905160
100negative regulation of organelle assembly (GO:1902116)2.93856101
101behavioral response to ethanol (GO:0048149)2.93002717
102carnitine transmembrane transport (GO:1902603)2.91572640
103sexual reproduction (GO:0019953)2.90965445
104water-soluble vitamin biosynthetic process (GO:0042364)2.89947339
105dopamine transport (GO:0015872)2.89560905
106cilium organization (GO:0044782)2.88661805
107mitotic sister chromatid cohesion (GO:0007064)2.86904652
108nucleobase catabolic process (GO:0046113)2.85749820
109photoreceptor cell maintenance (GO:0045494)2.85676632
110microtubule-based movement (GO:0007018)2.85311910
111intraciliary transport (GO:0042073)2.84876463
112regulation of rhodopsin mediated signaling pathway (GO:0022400)2.83934690
113C4-dicarboxylate transport (GO:0015740)2.80882115
114centriole assembly (GO:0098534)2.80101584
115gamma-aminobutyric acid transport (GO:0015812)2.79558393
116cilium assembly (GO:0042384)2.76979203
117rRNA catabolic process (GO:0016075)2.76759542
118alditol metabolic process (GO:0019400)2.76491936
119tryptophan metabolic process (GO:0006568)2.76127784
120UTP metabolic process (GO:0046051)2.75849272
121cellular component assembly involved in morphogenesis (GO:0010927)2.75428695
122rhodopsin mediated signaling pathway (GO:0016056)2.75389608
123limb bud formation (GO:0060174)2.69706452
124reciprocal meiotic recombination (GO:0007131)2.69269469
125reciprocal DNA recombination (GO:0035825)2.69269469
126cilium morphogenesis (GO:0060271)2.69162027
127sulfation (GO:0051923)2.68599486
128glycolytic process (GO:0006096)2.67592147
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.67150431
130L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66599538
131axoneme assembly (GO:0035082)2.65975350
132positive regulation of macrophage activation (GO:0043032)2.65916962
133regulation of protein glycosylation (GO:0060049)2.65241887
134neuronal action potential (GO:0019228)2.62580842
135nuclear pore complex assembly (GO:0051292)2.61672536
136fucosylation (GO:0036065)2.61285327
137regulation of acrosome reaction (GO:0060046)2.60895309
138DNA double-strand break processing (GO:0000729)2.60679510
139neuron cell-cell adhesion (GO:0007158)2.60504531
140lactate metabolic process (GO:0006089)2.60380947
141aromatic amino acid family catabolic process (GO:0009074)2.59251115
142meiotic chromosome segregation (GO:0045132)2.56638761
143retinal cone cell development (GO:0046549)2.54416346
144adult feeding behavior (GO:0008343)2.54287391
145kidney morphogenesis (GO:0060993)2.53771480
146establishment of protein localization to Golgi (GO:0072600)2.53520121
147protein localization to chromosome, centromeric region (GO:0071459)2.52806093
148protein-chromophore linkage (GO:0018298)2.52019956
149L-methionine salvage (GO:0071267)2.51773557
150L-methionine biosynthetic process (GO:0071265)2.51773557
151amino acid salvage (GO:0043102)2.51773557
152CTP metabolic process (GO:0046036)2.49961881
153CTP biosynthetic process (GO:0006241)2.49961881
154indole-containing compound metabolic process (GO:0042430)2.48586243
155positive regulation of amino acid transport (GO:0051957)2.46768220
156presynaptic membrane assembly (GO:0097105)2.46667859
157sympathetic nervous system development (GO:0048485)2.45610025
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44626864
159cornea development in camera-type eye (GO:0061303)2.44544528
160auditory receptor cell stereocilium organization (GO:0060088)2.42514360
161mannosylation (GO:0097502)2.42190442
162positive regulation of glycolytic process (GO:0045821)2.41809812
163recombinational repair (GO:0000725)2.41803652
164amine catabolic process (GO:0009310)2.41612244
165cellular biogenic amine catabolic process (GO:0042402)2.41612244
166membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40803006
167double-strand break repair via homologous recombination (GO:0000724)2.39927311
168glutamate receptor signaling pathway (GO:0007215)2.39309417
169respiratory chain complex IV assembly (GO:0008535)2.39295963
170startle response (GO:0001964)2.39274759
171regulation of action potential (GO:0098900)2.38620075
172postsynaptic membrane organization (GO:0001941)2.38530924
173fusion of sperm to egg plasma membrane (GO:0007342)14.0689675
174cell wall macromolecule metabolic process (GO:0044036)13.3503170
175cell wall macromolecule catabolic process (GO:0016998)13.3503170
176sperm motility (GO:0030317)12.9638913
177acrosome assembly (GO:0001675)12.3388267
178sperm-egg recognition (GO:0035036)11.7953188
179multicellular organism reproduction (GO:0032504)11.6111485
180acrosome reaction (GO:0007340)11.2518070
181plasma membrane fusion (GO:0045026)10.6956783
182cilium or flagellum-dependent cell motility (GO:0001539)10.6915448
183binding of sperm to zona pellucida (GO:0007339)10.6008356
184cell-cell recognition (GO:0009988)10.5564403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.98960088
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.77663351
3EZH2_22144423_ChIP-Seq_EOC_Human3.92183939
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66775430
5GBX2_23144817_ChIP-Seq_PC3_Human3.55347389
6IGF1R_20145208_ChIP-Seq_DFB_Human3.07888403
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.01449982
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00078293
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78625042
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53571175
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.46885016
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34700236
13P300_19829295_ChIP-Seq_ESCs_Human2.22482202
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22311413
15ER_23166858_ChIP-Seq_MCF-7_Human2.18915569
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17491390
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17457637
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13001376
19FUS_26573619_Chip-Seq_HEK293_Human2.03883091
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03232841
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00606932
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.00244709
23EWS_26573619_Chip-Seq_HEK293_Human1.99398823
24ZNF274_21170338_ChIP-Seq_K562_Hela1.97218709
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97150424
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95116871
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.94671250
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87856187
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86657146
30VDR_22108803_ChIP-Seq_LS180_Human1.85507807
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84321742
32STAT1_17558387_ChIP-Seq_HELA_Human1.80860047
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75255408
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74533143
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.72858149
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72046151
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69433531
38AR_21572438_ChIP-Seq_LNCaP_Human1.68393798
39* STAT3_23295773_ChIP-Seq_U87_Human1.67983287
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.67021743
41SMAD4_21799915_ChIP-Seq_A2780_Human1.66106329
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63345263
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.63044469
44TAF15_26573619_Chip-Seq_HEK293_Human1.61593247
45AR_25329375_ChIP-Seq_VCAP_Human1.61153829
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60052289
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58644047
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58164891
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58136813
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.56798645
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.54863186
52* TCF4_23295773_ChIP-Seq_U87_Human1.54758046
53BCAT_22108803_ChIP-Seq_LS180_Human1.54203398
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53558139
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.53032795
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52267413
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.51072413
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.49896795
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48446524
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.47538056
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46750037
62KDM2B_26808549_Chip-Seq_REH_Human1.44853914
63* SOX2_19829295_ChIP-Seq_ESCs_Human1.44031800
64* NANOG_19829295_ChIP-Seq_ESCs_Human1.44031800
65TCF4_22108803_ChIP-Seq_LS180_Human1.44013720
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41736262
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38773629
68CBP_20019798_ChIP-Seq_JUKART_Human1.38773629
69IRF1_19129219_ChIP-ChIP_H3396_Human1.38729232
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38329470
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37326341
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37119821
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34055203
74TP53_22573176_ChIP-Seq_HFKS_Human1.33804459
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.33553597
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.31698808
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.31509498
78RUNX2_22187159_ChIP-Seq_PCA_Human1.30767939
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29037573
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28828864
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.27375651
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26539492
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26130651
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26038399
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25226598
86P53_21459846_ChIP-Seq_SAOS-2_Human1.23731057
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23381758
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.22559844
89NCOR_22424771_ChIP-Seq_293T_Human1.21911618
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21633326
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20266818
92GF1_26923725_Chip-Seq_HPCs_Mouse1.20117855
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20064830
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.19771216
95SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19756493
96RNF2_27304074_Chip-Seq_NSC_Mouse1.16824277
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.16814462
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.15507195
99CDX2_22108803_ChIP-Seq_LS180_Human1.14872544
100* GATA3_21878914_ChIP-Seq_MCF-7_Human1.14173292
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13458738
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13167886
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.13167886
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12849201
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12408127
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12286941
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.12185480
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11995129
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10753160
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10280888
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09514210
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09287900
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08530476
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08160183
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06983394
116P53_22387025_ChIP-Seq_ESCs_Mouse1.06857998
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06437127
118REST_21632747_ChIP-Seq_MESCs_Mouse1.06120536
119P300_18555785_Chip-Seq_ESCs_Mouse1.05660482
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05383743
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.04829720
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04798986
123AR_20517297_ChIP-Seq_VCAP_Human1.04679692
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.04624865
125HOXB7_26014856_ChIP-Seq_BT474_Human1.03946152
126RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03541737
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02665470
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.02593610
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.01554580
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01326020
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01326020
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.01105062
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00390082
134ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00127308
135ERG_20517297_ChIP-Seq_VCAP_Human0.99348670
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99308741
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99195832
138LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99142684
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98671568
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97840728
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97373975
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.96762131
143* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96637248
144MYC_18940864_ChIP-ChIP_HL60_Human0.95988552
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94648962
146RXR_22108803_ChIP-Seq_LS180_Human0.94236784
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94185524
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.93842518
149STAT3_18555785_Chip-Seq_ESCs_Mouse0.93581902
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.93061829
151FLI1_21867929_ChIP-Seq_CD8_Mouse0.92720058
152* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91689331
153TBL1_22424771_ChIP-Seq_293T_Human0.91438951
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.91275269
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90541014
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89799676
157SOX9_26525672_Chip-Seq_HEART_Mouse0.89526055
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.88476523
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87888969
160NFYB_21822215_ChIP-Seq_K562_Human0.87647216
161CTCF_18555785_Chip-Seq_ESCs_Mouse0.87502103
162PU1_27457419_Chip-Seq_LIVER_Mouse0.87446599
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85388417
164CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85047351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05026048
2MP0001929_abnormal_gametogenesis5.65895690
3MP0008877_abnormal_DNA_methylation4.84156966
4MP0002837_dystrophic_cardiac_calcinosis3.89203430
5MP0002210_abnormal_sex_determination3.60288538
6MP0003136_yellow_coat_color3.38052220
7MP0002161_abnormal_fertility/fecundity3.31173348
8MP0001145_abnormal_male_reproductive3.03347500
9MP0001968_abnormal_touch/_nociception2.82277664
10MP0000653_abnormal_sex_gland2.69651442
11MP0002653_abnormal_ependyma_morphology2.62350673
12MP0005670_abnormal_white_adipose2.56708162
13MP0003195_calcinosis2.55879274
14MP0003880_abnormal_central_pattern2.20855616
15MP0009745_abnormal_behavioral_response2.03107803
16MP0005410_abnormal_fertilization15.9679793
17MP0008875_abnormal_xenobiotic_pharmacok1.87599167
18MP0008872_abnormal_physiological_respon1.85819304
19MP0004885_abnormal_endolymph1.85277316
20MP0005171_absent_coat_pigmentation1.82251853
21MP0004043_abnormal_pH_regulation1.78364201
22MP0001501_abnormal_sleep_pattern1.77412438
23MP0000427_abnormal_hair_cycle1.76170805
24MP0005174_abnormal_tail_pigmentation1.74479557
25MP0005623_abnormal_meninges_morphology1.71381846
26MP0001486_abnormal_startle_reflex1.69662814
27MP0002735_abnormal_chemical_nociception1.67742126
28MP0002160_abnormal_reproductive_system1.64674288
29MP0005075_abnormal_melanosome_morpholog1.63878405
30MP0002272_abnormal_nervous_system1.61686798
31MP0004147_increased_porphyrin_level1.61664713
32MP0001986_abnormal_taste_sensitivity1.58256493
33MP0002876_abnormal_thyroid_physiology1.56428107
34MP0005646_abnormal_pituitary_gland1.54035622
35MP0003646_muscle_fatigue1.49956656
36MP0006292_abnormal_olfactory_placode1.48773393
37MP0002638_abnormal_pupillary_reflex1.48357886
38MP0008058_abnormal_DNA_repair1.42576057
39MP0004381_abnormal_hair_follicle1.35196761
40MP0006276_abnormal_autonomic_nervous1.32630588
41MP0004924_abnormal_behavior1.32490191
42MP0005386_behavior/neurological_phenoty1.32490191
43MP0002064_seizures1.27061438
44MP0004233_abnormal_muscle_weight1.26690372
45MP0002282_abnormal_trachea_morphology1.25980123
46MP0005379_endocrine/exocrine_gland_phen1.23434221
47MP0003045_fibrosis1.22812401
48MP0010094_abnormal_chromosome_stability1.22225135
49MP0003890_abnormal_embryonic-extraembry1.21424140
50MP0005365_abnormal_bile_salt1.21034825
51MP0003635_abnormal_synaptic_transmissio1.20794042
52MP0000372_irregular_coat_pigmentation1.20097063
53MP0002572_abnormal_emotion/affect_behav1.19765517
54MP0003252_abnormal_bile_duct1.17980591
55MP0003718_maternal_effect1.17344844
56MP0001970_abnormal_pain_threshold1.11770402
57MP0002163_abnormal_gland_morphology1.10675336
58MP0005085_abnormal_gallbladder_physiolo1.09593731
59MP0001765_abnormal_ion_homeostasis1.09186088
60MP0002938_white_spotting1.08813439
61MP0002138_abnormal_hepatobiliary_system1.06864609
62MP0002557_abnormal_social/conspecific_i1.05266733
63MP0001529_abnormal_vocalization1.04663660
64MP0004142_abnormal_muscle_tone1.03128230
65MP0002229_neurodegeneration1.02761492
66MP0008995_early_reproductive_senescence1.01772765
67MP0002067_abnormal_sensory_capabilities1.01133378
68MP0005647_abnormal_sex_gland0.99290304
69MP0002254_reproductive_system_inflammat0.96871811
70MP0002751_abnormal_autonomic_nervous0.95162525
71MP0009046_muscle_twitch0.94824816
72MP0002095_abnormal_skin_pigmentation0.94536107
73MP0002063_abnormal_learning/memory/cond0.93850444
74MP0002733_abnormal_thermal_nociception0.92093579
75MP0010386_abnormal_urinary_bladder0.91935352
76MP0004215_abnormal_myocardial_fiber0.89751234
77MP0001485_abnormal_pinna_reflex0.89147293
78MP0005187_abnormal_penis_morphology0.89002425
79MP0001905_abnormal_dopamine_level0.88311536
80MP0005389_reproductive_system_phenotype0.86988258
81MP0005084_abnormal_gallbladder_morpholo0.85294833
82MP0000647_abnormal_sebaceous_gland0.85115004
83MP0008057_abnormal_DNA_replication0.85112841
84MP0000538_abnormal_urinary_bladder0.83555214
85MP0003137_abnormal_impulse_conducting0.82415544
86MP0000631_abnormal_neuroendocrine_gland0.82039545
87MP0008775_abnormal_heart_ventricle0.79872438
88MP0004133_heterotaxia0.79564756
89MP0002234_abnormal_pharynx_morphology0.77671075
90MP0003111_abnormal_nucleus_morphology0.76840783
91MP0001984_abnormal_olfaction0.76719291
92MP0005423_abnormal_somatic_nervous0.75213632
93MP0005645_abnormal_hypothalamus_physiol0.74923271
94MP0001919_abnormal_reproductive_system0.74136485
95MP0003878_abnormal_ear_physiology0.73800068
96MP0005377_hearing/vestibular/ear_phenot0.73800068
97MP0002102_abnormal_ear_morphology0.73253786
98MP0005332_abnormal_amino_acid0.73097911
99MP0000383_abnormal_hair_follicle0.73006420
100MP0008007_abnormal_cellular_replicative0.72447368
101MP0005195_abnormal_posterior_eye0.71988834
102MP0000516_abnormal_urinary_system0.70911320
103MP0005367_renal/urinary_system_phenotyp0.70911320
104MP0005395_other_phenotype0.69921546
105MP0003868_abnormal_feces_composition0.68722652
106MP0003011_delayed_dark_adaptation0.68658871
107MP0003787_abnormal_imprinting0.67838481
108MP0003786_premature_aging0.64514639
109MP0003699_abnormal_female_reproductive0.63420700
110MP0005636_abnormal_mineral_homeostasis0.61612110
111MP0003115_abnormal_respiratory_system0.58789264
112MP0002928_abnormal_bile_duct0.56333979
113MP0003693_abnormal_embryo_hatching0.55574455
114MP0005397_hematopoietic_system_phenotyp0.54055847
115MP0001545_abnormal_hematopoietic_system0.54055847
116MP0001119_abnormal_female_reproductive0.50887041
117MP0004036_abnormal_muscle_relaxation0.50654751
118MP0001293_anophthalmia0.49572835
119MP0003077_abnormal_cell_cycle0.48109957
120MP0009697_abnormal_copulation0.46904900
121MP0006036_abnormal_mitochondrial_physio0.46833988
122MP0001730_embryonic_growth_arrest0.46312201
123MP0001324_abnormal_eye_pigmentation0.45882104
124MP0000358_abnormal_cell_content/0.44927049
125MP0001764_abnormal_homeostasis0.44842823
126MP0003950_abnormal_plasma_membrane0.42906461
127MP0004808_abnormal_hematopoietic_stem0.40960239
128MP0005253_abnormal_eye_physiology0.40789667
129MP0002132_abnormal_respiratory_system0.37634624
130MP0001727_abnormal_embryo_implantation0.35680178
131MP0009278_abnormal_bone_marrow0.35637237
132MP0005551_abnormal_eye_electrophysiolog0.34641654
133MP0000313_abnormal_cell_death0.34246476
134MP0005391_vision/eye_phenotype0.33445003
135MP0004019_abnormal_vitamin_homeostasis0.30608912
136MP0003879_abnormal_hair_cell0.29446339
137MP0010307_abnormal_tumor_latency0.28765382
138MP0004742_abnormal_vestibular_system0.27443272
139MP0005666_abnormal_adipose_tissue0.27366116
140MP0000462_abnormal_digestive_system0.25287892
141MP0002269_muscular_atrophy0.24860199
142MP0004957_abnormal_blastocyst_morpholog0.24364677
143MP0000569_abnormal_digit_pigmentation0.24324921
144MP0001672_abnormal_embryogenesis/_devel0.24173552
145MP0005380_embryogenesis_phenotype0.24173552
146MP0002736_abnormal_nociception_after0.23246478
147MP0006072_abnormal_retinal_apoptosis0.23000828
148MP0002169_no_abnormal_phenotype0.22588799
149MP0002873_normal_phenotype0.22394464
150MP0002084_abnormal_developmental_patter0.22056269
151MP0002092_abnormal_eye_morphology0.20986630
152MP0002009_preneoplasia0.20432737
153MP0003861_abnormal_nervous_system0.19870480
154MP0001697_abnormal_embryo_size0.19728464
155MP0003984_embryonic_growth_retardation0.18465280
156MP0003633_abnormal_nervous_system0.18288751
157MP0002405_respiratory_system_inflammati0.17830930
158MP0009115_abnormal_fat_cell0.17793809
159MP0008932_abnormal_embryonic_tissue0.17731049
160MP0001270_distended_abdomen0.17260066
161MP0000678_abnormal_parathyroid_gland0.16868118
162MP0004134_abnormal_chest_morphology0.16350594
163MP0002088_abnormal_embryonic_growth/wei0.15702122
164MP0002080_prenatal_lethality0.15308974
165MP0003631_nervous_system_phenotype0.15249423
166MP0003329_amyloid_beta_deposits0.15225523
167MP0003948_abnormal_gas_homeostasis0.14580304
168MP0000001_mammalian_phenotype0.14521528
169MP0000015_abnormal_ear_pigmentation0.14475923
170MP0002295_abnormal_pulmonary_circulatio0.13899867
171MP0002085_abnormal_embryonic_tissue0.13484989
172MP0002971_abnormal_brown_adipose0.13359898
173MP0004811_abnormal_neuron_physiology0.13141894
174MP0002693_abnormal_pancreas_physiology0.12596063
175MP0003315_abnormal_perineum_morphology0.12577880

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.51791692
2Abnormal respiratory motile cilium morphology (HP:0005938)9.20999295
3Abnormal respiratory epithelium morphology (HP:0012253)9.20999295
4Abnormal ciliary motility (HP:0012262)7.73493948
5Rhinitis (HP:0012384)7.66733863
6Chronic bronchitis (HP:0004469)7.36765231
7Infertility (HP:0000789)6.67591540
8Nasal polyposis (HP:0100582)6.47706450
9Abnormality of the nasal mucosa (HP:0000433)5.35653411
10Male infertility (HP:0003251)4.77383688
11Bronchitis (HP:0012387)4.61526904
12Focal motor seizures (HP:0011153)4.60273040
13Bronchiectasis (HP:0002110)4.50382674
14Hyperventilation (HP:0002883)4.32422376
15Nephronophthisis (HP:0000090)4.29408361
16Pancreatic cysts (HP:0001737)4.28668300
17Abnormal spermatogenesis (HP:0008669)3.85371298
18Type II lissencephaly (HP:0007260)3.70051442
19Recurrent sinusitis (HP:0011108)3.68319644
20True hermaphroditism (HP:0010459)3.40540916
21Recurrent otitis media (HP:0000403)3.32348628
22Abnormality of the renal medulla (HP:0100957)3.22454581
23Focal seizures (HP:0007359)3.14814055
24Congenital stationary night blindness (HP:0007642)3.14264193
25Renal cortical cysts (HP:0000803)3.08890398
26Gaze-evoked nystagmus (HP:0000640)2.82664154
27Pendular nystagmus (HP:0012043)2.80943509
28Stomach cancer (HP:0012126)2.79200538
29Recurrent bronchitis (HP:0002837)2.78034686
30Medial flaring of the eyebrow (HP:0010747)2.77869951
31Attenuation of retinal blood vessels (HP:0007843)2.77548946
32Tubulointerstitial nephritis (HP:0001970)2.75949877
33Abnormal rod and cone electroretinograms (HP:0008323)2.73047220
34Chronic hepatic failure (HP:0100626)2.68210228
35Abolished electroretinogram (ERG) (HP:0000550)2.68114721
36Molar tooth sign on MRI (HP:0002419)2.64905500
37Abnormality of midbrain morphology (HP:0002418)2.64905500
38Absent speech (HP:0001344)2.64580762
39Inability to walk (HP:0002540)2.62105221
40Impulsivity (HP:0100710)2.61396915
41Progressive inability to walk (HP:0002505)2.60156066
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59631032
43Dialeptic seizures (HP:0011146)2.55354364
44Lissencephaly (HP:0001339)2.54947940
45Fair hair (HP:0002286)2.52819509
46Tubular atrophy (HP:0000092)2.49534403
47Azoospermia (HP:0000027)2.47863673
48Febrile seizures (HP:0002373)2.41302157
49Tubulointerstitial abnormality (HP:0001969)2.39743753
50Gonadotropin excess (HP:0000837)2.39270011
513-Methylglutaconic aciduria (HP:0003535)2.35831160
52Abnormality of macular pigmentation (HP:0008002)2.35387407
53Ketoacidosis (HP:0001993)2.35340454
54Broad-based gait (HP:0002136)2.32060934
55Protruding tongue (HP:0010808)2.31990218
56Polyuria (HP:0000103)2.29754553
57Methylmalonic aciduria (HP:0012120)2.29737575
58Amelogenesis imperfecta (HP:0000705)2.23141534
59Hemiparesis (HP:0001269)2.22281216
60Widely spaced teeth (HP:0000687)2.19120594
61Progressive cerebellar ataxia (HP:0002073)2.18485914
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.18471864
63Bony spicule pigmentary retinopathy (HP:0007737)2.15439412
64Hypothermia (HP:0002045)2.12067888
65Colon cancer (HP:0003003)2.11828678
66Clumsiness (HP:0002312)2.08003662
67Methylmalonic acidemia (HP:0002912)2.07185379
68Dyschromatopsia (HP:0007641)2.04773795
69Hypoproteinemia (HP:0003075)2.04458500
70Thyroiditis (HP:0100646)2.03348737
71Retinal dysplasia (HP:0007973)2.00270035
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5852156
73Absent/shortened dynein arms (HP:0200106)13.2427060
74Dynein arm defect of respiratory motile cilia (HP:0012255)13.2427060
75Ketosis (HP:0001946)1.99055230
76Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98259523
77Pachygyria (HP:0001302)1.97486877
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.97304442
79Congenital sensorineural hearing impairment (HP:0008527)1.96037863
80Tubulointerstitial fibrosis (HP:0005576)1.95488067
81Increased corneal curvature (HP:0100692)1.95141482
82Keratoconus (HP:0000563)1.95141482
83Abnormality of the labia minora (HP:0012880)1.94669811
84Progressive microcephaly (HP:0000253)1.93733178
85Decreased central vision (HP:0007663)1.92329432
86Postaxial foot polydactyly (HP:0001830)1.90212775
87Small hand (HP:0200055)1.89233021
88Abnormal gallbladder physiology (HP:0012438)1.88656459
89Cholecystitis (HP:0001082)1.88656459
90Optic nerve hypoplasia (HP:0000609)1.88591402
91Hypoplastic iliac wings (HP:0002866)1.88546843
92Generalized hypopigmentation of hair (HP:0011358)1.84793774
93Volvulus (HP:0002580)1.83792101
94Congenital hepatic fibrosis (HP:0002612)1.83195484
95Abnormal protein glycosylation (HP:0012346)1.79533910
96Abnormal glycosylation (HP:0012345)1.79533910
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79533910
98Abnormal protein N-linked glycosylation (HP:0012347)1.79533910
99Glioma (HP:0009733)1.78630767
100Intestinal atresia (HP:0011100)1.78478816
101Fibular hypoplasia (HP:0003038)1.77602380
102Abnormality of the renal cortex (HP:0011035)1.76982552
103Neoplasm of the adrenal cortex (HP:0100641)1.76279669
104Large for gestational age (HP:0001520)1.74807407
105Stage 5 chronic kidney disease (HP:0003774)1.74783461
106Male pseudohermaphroditism (HP:0000037)1.74272247
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71867076
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71447960
109Abnormality of alanine metabolism (HP:0010916)1.71447960
110Hyperalaninemia (HP:0003348)1.71447960
111Spastic tetraparesis (HP:0001285)1.70631791
112Sclerocornea (HP:0000647)1.70458990
113Polydipsia (HP:0001959)1.69702187
114Abnormal drinking behavior (HP:0030082)1.69702187
115Severe visual impairment (HP:0001141)1.69467782
116Abnormality of the pons (HP:0007361)1.68892786
117Abnormal albumin level (HP:0012116)1.68886127
118Hypoalbuminemia (HP:0003073)1.68886127
119Anencephaly (HP:0002323)1.68226526
120Severe muscular hypotonia (HP:0006829)1.67607218
121Type I transferrin isoform profile (HP:0003642)1.67312975
122Abnormality of the lower motor neuron (HP:0002366)1.63092838
123Choroideremia (HP:0001139)1.62905628
124Short ribs (HP:0000773)1.58570391
125Abnormality of renal excretion (HP:0011036)1.58516403
126Congenital primary aphakia (HP:0007707)1.54313197
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54014076
128Absent epiphyses (HP:0010577)1.54014076
129Postaxial hand polydactyly (HP:0001162)1.53959146
130Abnormality of the dental root (HP:0006486)1.52943932
131Taurodontia (HP:0000679)1.52943932
132Abnormality of permanent molar morphology (HP:0011071)1.52943932
133Chronic sinusitis (HP:0011109)1.52938545
134Gait imbalance (HP:0002141)1.52359248
135Oculomotor apraxia (HP:0000657)1.51691939
136Renal dysplasia (HP:0000110)1.51436427
137Facial cleft (HP:0002006)1.51267331
138Heterotopia (HP:0002282)1.51152158
139Bile duct proliferation (HP:0001408)1.50060646
140Abnormal biliary tract physiology (HP:0012439)1.50060646
141Absent frontal sinuses (HP:0002688)1.49719860
142Aplasia/Hypoplasia of the lens (HP:0008063)1.49092044
143Microglossia (HP:0000171)1.47649976
144Pancreatic fibrosis (HP:0100732)1.46731181
145Abnormality of molar (HP:0011077)1.43905242
146Abnormality of molar morphology (HP:0011070)1.43905242
147Hemorrhage of the eye (HP:0011885)1.42069874
148Bell-shaped thorax (HP:0001591)1.39464902
149Abnormality of the dental pulp (HP:0006479)1.38558747
150J-shaped sella turcica (HP:0002680)1.36659207
151Deformed sella turcica (HP:0002681)1.34604058
152Median cleft lip (HP:0000161)1.33196496
153Cystic liver disease (HP:0006706)1.30932981
154Nephrogenic diabetes insipidus (HP:0009806)1.30844454
155Broad distal phalanx of finger (HP:0009836)1.28078003
156Abnormality of dentin (HP:0010299)1.27907509
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.26680687
158Abnormal urine output (HP:0012590)1.25132873
159Supernumerary spleens (HP:0009799)1.24907765
160Constricted visual fields (HP:0001133)1.24736053
161Amyotrophic lateral sclerosis (HP:0007354)1.23553379
162Abnormality of saccadic eye movements (HP:0000570)1.22399966
163Impaired proprioception (HP:0010831)1.22270517
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.21882666
165Double outlet right ventricle (HP:0001719)1.21322659
166Congenital malformation of the right heart (HP:0011723)1.21322659
167Short thorax (HP:0010306)1.21205925
168Bundle branch block (HP:0011710)1.21027036
169Decreased electroretinogram (ERG) amplitude (HP:0000654)1.20006130
170Asymmetric septal hypertrophy (HP:0001670)1.20000080
171Genital tract atresia (HP:0001827)1.19111571
172Nephropathy (HP:0000112)1.18830230
173Abnormality of ocular smooth pursuit (HP:0000617)1.17692541
174Breast carcinoma (HP:0003002)1.17555622
175Short femoral neck (HP:0100864)1.16223616
176Vaginal atresia (HP:0000148)1.15033909
177Cerebellar dysplasia (HP:0007033)1.14546007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.39290493
2PDK48.39290493
3FRK5.88337294
4TESK15.61087231
5PDK25.38623871
6PRKD34.69575374
7ICK3.88407905
8BMPR1B3.33170703
9LATS13.25791971
10TAOK33.19943938
11ZAK2.83383128
12ACVR1B2.69319087
13PTK2B2.30788788
14NUAK12.28060110
15STK392.26952800
16WNK42.19812598
17MARK12.17331578
18ADRBK22.09743879
19NEK22.04882486
20MAP4K21.98645664
21PNCK1.97466868
22INSRR1.95964228
23MAPK131.91979923
24STK381.88431511
25TNIK1.84615242
26GRK11.70865876
27CASK1.42367976
28EIF2AK31.26208043
29CSNK1A1L1.25949067
30MAP3K41.23524320
31DYRK1B1.19600929
32CSNK1G31.18923468
33NLK1.17034647
34STK38L1.16421384
35FGFR21.14944573
36CSNK1G11.14420692
37NTRK31.12275628
38PDK11.11118489
39CSNK1G21.10368950
40EPHA41.09925497
41CCNB11.06587764
42TGFBR11.03611407
43PHKG21.01591520
44PHKG11.01591520
45CAMKK20.99771835
46GRK50.94273731
47PRKCE0.92837847
48PASK0.92693185
49MAPK150.91284976
50PLK20.90603666
51TTK0.89189943
52DYRK30.86723002
53TRIM280.83967358
54VRK10.83580998
55CHEK20.82873059
56TXK0.82755334
57ADRBK10.81592512
58TYRO30.80416099
59DYRK20.80144118
60CDC70.75598005
61ERBB30.75146230
62WNK10.74719162
63PAK30.72172671
64MAP2K70.71487399
65IRAK10.69765205
66IKBKB0.69762506
67LMTK20.69326738
68MAP2K60.68084345
69BCKDK0.65729448
70MAPKAPK30.65133202
71MKNK20.64777737
72PDPK10.63393004
73PRKAA20.62780722
74STK30.61911721
75PLK30.59681554
76OBSCN0.59122334
77FER0.58939478
78WEE10.58537095
79PINK10.56938322
80TEC0.56771023
81YES10.56004819
82MAP3K70.53867026
83CAMK1G0.52067643
84DAPK20.51511861
85CHEK10.51208505
86PLK40.48305122
87CSNK1A10.47228783
88EPHA30.45251034
89EEF2K0.45228719
90CAMK2A0.44840172
91MAP2K20.44471380
92GRK70.42058965
93ATR0.41798358
94PLK10.41637294
95GRK60.39663843
96TNK20.39454391
97PAK10.39373025
98IRAK20.39314094
99TESK20.39171521
100MST40.37526207
101ATM0.37136042
102BRD40.35798667
103PRKACA0.34354523
104MAP2K10.34070932
105NEK60.33631127
106ITK0.33617430
107RIPK40.33185396
108CAMK10.32290281
109MUSK0.32289811
110BRSK20.31718823
111MAPKAPK50.31151665
112SYK0.30969459
113FLT30.29470542
114PIK3CA0.29291025
115ABL10.29216492
116MINK10.28519485
117ROCK10.28217990
118KIT0.27871001
119PRKCG0.27551886
120RPS6KB10.26859184
121CAMK2D0.26771391
122IGF1R0.26539745
123PAK20.22400902
124CDK60.22297332
125BUB10.20449903
126PRKAA10.19848401
127BRSK10.19183050
128MTOR0.18328001
129NTRK20.15314270
130CSNK2A10.15161126
131AURKB0.14985953
132PRKG20.14526166
133PIK3CG0.14391642
134CAMKK10.14376927
135TLK10.14179765
136PKN10.13699002
137STK100.13270891
138CDK30.12881445
139CDK40.12820162
140WNK30.12574978
141PIM10.12050388
142PAK40.11933448
143MAP3K100.11572117
144CSNK2A20.11049657
145BCR0.10306406
146AURKA0.10143990
147CDK20.10044516
148CDK10.08665869
149BRAF0.08592464
150ZAP700.07278224
151GSK3B0.06835439
152MARK20.05640344
153CDK150.05631092
154PRKCQ0.04746920
155STK160.04308253
156PRKG10.04169868
157CSF1R0.03648112
158CDK11A0.03642969
159PRKACG0.03267015
160SCYL20.03191539
161CDK180.03172826
162CSNK1D0.02830969
163RPS6KA10.02412021
164PRKDC0.02207016
165PRKCZ0.01884393
166OXSR10.01169822
167PRKCB0.00956361
168CDK90.00524114
169CDK120.00381340
170PRKCD-0.0087118
171STK11-0.0073866
172MARK3-0.0064141
173MAPK8-0.0023802
174MAP3K5-0.0018689

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.71368644
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.12879417
3Fatty acid biosynthesis_Homo sapiens_hsa000614.03921646
4Pyruvate metabolism_Homo sapiens_hsa006203.52432243
5Basal transcription factors_Homo sapiens_hsa030223.36173360
6Phototransduction_Homo sapiens_hsa047443.33561698
7Butanoate metabolism_Homo sapiens_hsa006503.13566952
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.10731841
9Propanoate metabolism_Homo sapiens_hsa006403.08789766
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.82664908
11Linoleic acid metabolism_Homo sapiens_hsa005912.72895404
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.51017314
13Glucagon signaling pathway_Homo sapiens_hsa049222.50337268
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46727950
15Pentose phosphate pathway_Homo sapiens_hsa000302.35908468
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35185857
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33908763
18Nitrogen metabolism_Homo sapiens_hsa009102.30276475
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.28979858
20Fanconi anemia pathway_Homo sapiens_hsa034602.27288209
21Nicotine addiction_Homo sapiens_hsa050332.26653732
22Selenocompound metabolism_Homo sapiens_hsa004502.13261151
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08018786
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03870345
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96774220
26Glycerolipid metabolism_Homo sapiens_hsa005611.85706904
27Oocyte meiosis_Homo sapiens_hsa041141.84919747
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84050693
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.83762828
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81347599
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75807594
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.75632532
33PPAR signaling pathway_Homo sapiens_hsa033201.73592846
34Tryptophan metabolism_Homo sapiens_hsa003801.72814463
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65639068
36RNA transport_Homo sapiens_hsa030131.59221291
37Olfactory transduction_Homo sapiens_hsa047401.58179830
38Huntingtons disease_Homo sapiens_hsa050161.53443829
39Protein export_Homo sapiens_hsa030601.48013934
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46654266
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.45524306
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.44772012
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.43845342
44Purine metabolism_Homo sapiens_hsa002301.38757361
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.37947591
46Mineral absorption_Homo sapiens_hsa049781.37243137
47Amphetamine addiction_Homo sapiens_hsa050311.36418525
48Fructose and mannose metabolism_Homo sapiens_hsa000511.33412583
49Carbon metabolism_Homo sapiens_hsa012001.32896949
50Morphine addiction_Homo sapiens_hsa050321.31131582
51Caffeine metabolism_Homo sapiens_hsa002321.28556420
52Ether lipid metabolism_Homo sapiens_hsa005651.27956846
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24992381
54Dorso-ventral axis formation_Homo sapiens_hsa043201.24746865
55mRNA surveillance pathway_Homo sapiens_hsa030151.24292641
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18606435
57Cardiac muscle contraction_Homo sapiens_hsa042601.18543154
58Peroxisome_Homo sapiens_hsa041461.16425174
59Fatty acid degradation_Homo sapiens_hsa000711.15758576
60Circadian entrainment_Homo sapiens_hsa047131.14543022
61Fatty acid metabolism_Homo sapiens_hsa012121.14050836
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.13673675
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13133802
64Fat digestion and absorption_Homo sapiens_hsa049751.12899020
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12225357
66Circadian rhythm_Homo sapiens_hsa047101.10619262
67Sphingolipid metabolism_Homo sapiens_hsa006001.09621090
68Antigen processing and presentation_Homo sapiens_hsa046121.08525112
69GABAergic synapse_Homo sapiens_hsa047271.04429643
70Glutamatergic synapse_Homo sapiens_hsa047241.01044432
71Retinol metabolism_Homo sapiens_hsa008300.99833640
72RNA polymerase_Homo sapiens_hsa030200.98927711
73Glutathione metabolism_Homo sapiens_hsa004800.95039700
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93994076
75beta-Alanine metabolism_Homo sapiens_hsa004100.91736150
76Renin secretion_Homo sapiens_hsa049240.91324310
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87236057
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86173737
79Serotonergic synapse_Homo sapiens_hsa047260.85692808
80Primary immunodeficiency_Homo sapiens_hsa053400.84970083
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83071038
82Biosynthesis of amino acids_Homo sapiens_hsa012300.81841589
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81138980
84Renin-angiotensin system_Homo sapiens_hsa046140.80871443
85Systemic lupus erythematosus_Homo sapiens_hsa053220.79543844
86Asthma_Homo sapiens_hsa053100.79526576
87Pyrimidine metabolism_Homo sapiens_hsa002400.79438245
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79263186
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76678830
90Arachidonic acid metabolism_Homo sapiens_hsa005900.76651237
91One carbon pool by folate_Homo sapiens_hsa006700.74584211
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71387353
93Homologous recombination_Homo sapiens_hsa034400.71250760
94Oxidative phosphorylation_Homo sapiens_hsa001900.70412128
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69648799
96Ovarian steroidogenesis_Homo sapiens_hsa049130.69620013
97Chemical carcinogenesis_Homo sapiens_hsa052040.68588776
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64783490
99DNA replication_Homo sapiens_hsa030300.63258789
100Long-term potentiation_Homo sapiens_hsa047200.62341231
101Estrogen signaling pathway_Homo sapiens_hsa049150.61883398
102Histidine metabolism_Homo sapiens_hsa003400.60542477
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60084694
104Dopaminergic synapse_Homo sapiens_hsa047280.59218850
105Non-homologous end-joining_Homo sapiens_hsa034500.56973960
106Collecting duct acid secretion_Homo sapiens_hsa049660.55670899
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55566823
108Type I diabetes mellitus_Homo sapiens_hsa049400.54549599
109Thyroid hormone synthesis_Homo sapiens_hsa049180.54337937
110Insulin secretion_Homo sapiens_hsa049110.53438987
111ABC transporters_Homo sapiens_hsa020100.53177260
112Steroid biosynthesis_Homo sapiens_hsa001000.52394015
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.51409367
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49447911
115RNA degradation_Homo sapiens_hsa030180.49335698
116Sulfur relay system_Homo sapiens_hsa041220.49300785
117Regulation of autophagy_Homo sapiens_hsa041400.48916167
118Metabolic pathways_Homo sapiens_hsa011000.47865668
119Hedgehog signaling pathway_Homo sapiens_hsa043400.45179511
120Legionellosis_Homo sapiens_hsa051340.44934453
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44878763
122Cell cycle_Homo sapiens_hsa041100.43733372
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.41741427
124Protein digestion and absorption_Homo sapiens_hsa049740.41302882
125Allograft rejection_Homo sapiens_hsa053300.41185959
126Bile secretion_Homo sapiens_hsa049760.40838758
127Base excision repair_Homo sapiens_hsa034100.39610981
128Calcium signaling pathway_Homo sapiens_hsa040200.39154792
129Inositol phosphate metabolism_Homo sapiens_hsa005620.38518039
130Autoimmune thyroid disease_Homo sapiens_hsa053200.38201239
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37304828
132Parkinsons disease_Homo sapiens_hsa050120.35867052
133Viral carcinogenesis_Homo sapiens_hsa052030.35233984
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34991820
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34902825
136Long-term depression_Homo sapiens_hsa047300.34873104
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34106149
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32575347
139AMPK signaling pathway_Homo sapiens_hsa041520.32220040
140Alcoholism_Homo sapiens_hsa050340.31412624
141Graft-versus-host disease_Homo sapiens_hsa053320.31134166
142Pancreatic secretion_Homo sapiens_hsa049720.31066746
143Fatty acid elongation_Homo sapiens_hsa000620.30866595
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29964302
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29493192
146N-Glycan biosynthesis_Homo sapiens_hsa005100.29147963
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27911732
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26798788
149VEGF signaling pathway_Homo sapiens_hsa043700.26116195
150Proteasome_Homo sapiens_hsa030500.25472002
151Endocytosis_Homo sapiens_hsa041440.24706148
152Epstein-Barr virus infection_Homo sapiens_hsa051690.24517738
153Spliceosome_Homo sapiens_hsa030400.22883882
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22152194
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20096897
156cAMP signaling pathway_Homo sapiens_hsa040240.18676335
157Taste transduction_Homo sapiens_hsa047420.18514173
158Vascular smooth muscle contraction_Homo sapiens_hsa042700.17751443
159Sulfur metabolism_Homo sapiens_hsa009200.14832068
160Salivary secretion_Homo sapiens_hsa049700.13969685
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13242481
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.13098247

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