HEATR5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.96139272
2positive regulation of granulocyte differentiation (GO:0030854)5.32617449
3regulation of B cell receptor signaling pathway (GO:0050855)5.07752052
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.06379423
5positive regulation of B cell differentiation (GO:0045579)4.76793153
6histone H3-K36 demethylation (GO:0070544)4.61923133
7B cell receptor signaling pathway (GO:0050853)4.58147571
8regulation of gamma-delta T cell differentiation (GO:0045586)4.56274667
9histone H3-K4 trimethylation (GO:0080182)4.54478137
10synaptic vesicle maturation (GO:0016188)4.45726328
11negative T cell selection (GO:0043383)4.35245615
12negative thymic T cell selection (GO:0045060)4.28770625
13regulation of gamma-delta T cell activation (GO:0046643)4.27636724
14positive T cell selection (GO:0043368)4.13828458
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05567384
16definitive hemopoiesis (GO:0060216)3.97866517
17cellular response to ethanol (GO:0071361)3.96358060
18regulation of B cell differentiation (GO:0045577)3.91042737
19cellular extravasation (GO:0045123)3.90025686
20negative regulation of erythrocyte differentiation (GO:0045647)3.88101608
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78647159
22positive thymic T cell selection (GO:0045059)3.75300275
23locomotory exploration behavior (GO:0035641)3.74029806
24peptidyl-lysine trimethylation (GO:0018023)3.61309491
25regulation of NFAT protein import into nucleus (GO:0051532)3.58080253
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57528226
27sodium ion export (GO:0071436)3.57100961
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55763702
29layer formation in cerebral cortex (GO:0021819)3.52402205
30T cell selection (GO:0045058)3.46789159
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46309059
32regulation of granulocyte differentiation (GO:0030852)3.44710982
33activation of protein kinase A activity (GO:0034199)3.39826619
34monoubiquitinated protein deubiquitination (GO:0035520)3.38871714
35histone lysine demethylation (GO:0070076)3.38137498
36proline transport (GO:0015824)3.32888218
37interkinetic nuclear migration (GO:0022027)3.31988813
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.31171311
39histone demethylation (GO:0016577)3.26915115
40hepatocyte apoptotic process (GO:0097284)3.24587875
41neutrophil mediated immunity (GO:0002446)3.22544927
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.22512712
43regulation of ARF protein signal transduction (GO:0032012)3.21235736
44dosage compensation (GO:0007549)3.20942304
45Golgi to endosome transport (GO:0006895)3.19879171
46cytoplasmic mRNA processing body assembly (GO:0033962)3.18284734
47glutamate secretion (GO:0014047)3.16649676
48response to interleukin-15 (GO:0070672)3.16494184
49megakaryocyte development (GO:0035855)3.16094658
50negative regulation of T cell mediated immunity (GO:0002710)3.09909228
51cell communication by electrical coupling (GO:0010644)3.09486666
52response to muramyl dipeptide (GO:0032495)3.06754059
53plasma membrane repair (GO:0001778)3.06039292
54regulation of clathrin-mediated endocytosis (GO:2000369)3.04510099
55establishment of nucleus localization (GO:0040023)3.04039090
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.03994437
57histone H3-K9 demethylation (GO:0033169)3.03356704
58thymic T cell selection (GO:0045061)3.00710479
59histone H3-K4 methylation (GO:0051568)3.00453378
60microglial cell activation (GO:0001774)2.96534048
61T cell migration (GO:0072678)2.93972057
62cellular potassium ion homeostasis (GO:0030007)2.92357366
63NLS-bearing protein import into nucleus (GO:0006607)2.89325639
64myeloid leukocyte mediated immunity (GO:0002444)2.88541843
65regulation of synaptic vesicle exocytosis (GO:2000300)2.86978662
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86273599
67positive regulation by organism of defense response of other organism involved in symbiotic interact2.86273599
68modulation by symbiont of host immune response (GO:0052553)2.86273599
69positive regulation by symbiont of host defense response (GO:0052509)2.86273599
70modulation by symbiont of host defense response (GO:0052031)2.86273599
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86273599
72activated T cell proliferation (GO:0050798)2.85420530
73negative regulation of lymphocyte mediated immunity (GO:0002707)2.84534638
74antigen receptor-mediated signaling pathway (GO:0050851)2.84058643
75antigen processing and presentation of endogenous antigen (GO:0019883)2.83776946
76phospholipid translocation (GO:0045332)2.82860353
77lipid translocation (GO:0034204)2.82860353
78protein demethylation (GO:0006482)2.82399035
79protein dealkylation (GO:0008214)2.82399035
80phosphatidylinositol dephosphorylation (GO:0046856)2.81986162
81positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81984942
82clathrin coat assembly (GO:0048268)2.79113573
83cerebellar Purkinje cell differentiation (GO:0021702)2.78503312
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76767732
85nerve growth factor signaling pathway (GO:0038180)2.76465392
86synaptic vesicle exocytosis (GO:0016079)2.76043067
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74430318
88detection of other organism (GO:0098543)2.74242519
89alanine transport (GO:0032328)2.73650028
90vesicle transport along microtubule (GO:0047496)2.72140712
91phospholipid dephosphorylation (GO:0046839)2.71323220
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70023968
93protein K11-linked deubiquitination (GO:0035871)2.69957627
94germinal center formation (GO:0002467)2.68757542
95histone mRNA catabolic process (GO:0071044)2.68749309
96neutrophil activation involved in immune response (GO:0002283)2.65521394
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64469814
98peptidyl-lysine dimethylation (GO:0018027)2.63770588
99macrophage activation involved in immune response (GO:0002281)2.63275230
100cellular response to interleukin-15 (GO:0071350)2.62336775
101macroautophagy (GO:0016236)2.59825519
102potassium ion import (GO:0010107)2.59740748
103negative regulation of cell size (GO:0045792)2.59054239
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58787166
105leukocyte aggregation (GO:0070486)2.57425792
106regulation of interferon-beta biosynthetic process (GO:0045357)2.57053409
107peptidyl-lysine methylation (GO:0018022)2.56155043
108positive regulation of histone deacetylation (GO:0031065)2.55994674
109establishment of protein localization to Golgi (GO:0072600)2.55542765
110protein localization to endosome (GO:0036010)2.55356420
111macrophage activation (GO:0042116)2.55249279
112immunoglobulin mediated immune response (GO:0016064)2.53296924
113pre-miRNA processing (GO:0031054)2.52200286
114detection of bacterium (GO:0016045)2.51880966
115regulation of synapse structural plasticity (GO:0051823)2.51150429
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51142843
117response to host immune response (GO:0052572)2.50487206
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50487206
119histone lysine methylation (GO:0034968)2.50218721
120exploration behavior (GO:0035640)2.50053106
121neurotransmitter secretion (GO:0007269)2.50030679
122regulation of germinal center formation (GO:0002634)2.49221087
123negative regulation of adaptive immune response (GO:0002820)2.49203078
124regulation of glutamate receptor signaling pathway (GO:1900449)2.49186537
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49168037
126mature B cell differentiation (GO:0002335)2.48865459
127protein targeting to Golgi (GO:0000042)2.48353239
128B cell homeostasis (GO:0001782)2.47649970
129regulation of synaptic vesicle transport (GO:1902803)2.47428596
130regulation of erythrocyte differentiation (GO:0045646)2.47283542
131negative regulation of leukocyte mediated immunity (GO:0002704)2.47282892
132positive regulation of glycogen biosynthetic process (GO:0045725)2.47030157
133peptidyl-threonine phosphorylation (GO:0018107)2.46933309
134regulation of alpha-beta T cell proliferation (GO:0046640)2.46058366
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.45248391
136negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45097986
137negative regulation of T-helper cell differentiation (GO:0045623)2.45097986
138histone H3-K9 modification (GO:0061647)2.44943709
139vocalization behavior (GO:0071625)2.43996592
140negative regulation of sodium ion transport (GO:0010766)2.43013047
141dendrite morphogenesis (GO:0048813)2.42027788
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.40966049
143peptidyl-threonine modification (GO:0018210)2.39184234
144myeloid cell activation involved in immune response (GO:0002275)2.39129252
145retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38482201
146positive regulation of fibroblast migration (GO:0010763)2.37445729
147growth hormone receptor signaling pathway (GO:0060396)2.36844605
148cell communication involved in cardiac conduction (GO:0086065)2.35424297
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33229021
150neuromuscular process controlling balance (GO:0050885)2.33058336
151regulation of fatty acid beta-oxidation (GO:0031998)2.33041216
152regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30000683
153organelle transport along microtubule (GO:0072384)2.29969339
154stress fiber assembly (GO:0043149)2.29359478
155regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.29091502
156prepulse inhibition (GO:0060134)2.27709678
157protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.26806675
158regulation of ARF GTPase activity (GO:0032312)2.25464007
159carnitine shuttle (GO:0006853)2.25060732
160cellular sodium ion homeostasis (GO:0006883)2.20615439
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18017566
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.17643128
163regulation of cAMP-dependent protein kinase activity (GO:2000479)2.17458928
164regulation of glycogen (starch) synthase activity (GO:2000465)2.16548381
165membrane repolarization (GO:0086009)2.15202376
166dicarboxylic acid biosynthetic process (GO:0043650)2.13490457
167positive regulation of nitric-oxide synthase activity (GO:0051000)2.13097912
168positive regulation of Rap GTPase activity (GO:0032854)2.12406305
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.11410682
170negative regulation of cell killing (GO:0031342)2.11410682
171glucocorticoid receptor signaling pathway (GO:0042921)2.11209868
172adherens junction assembly (GO:0034333)2.11109048
173regulation of Rap GTPase activity (GO:0032317)2.10472532
174suckling behavior (GO:0001967)2.10469409
175regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.10439073
176COPI coating of Golgi vesicle (GO:0048205)2.10157572
177Golgi transport vesicle coating (GO:0048200)2.10157572
178regulation of polysaccharide biosynthetic process (GO:0032885)2.09838437
179apoptotic cell clearance (GO:0043277)2.09587976
180negative regulation of organelle assembly (GO:1902116)2.09388658
181positive regulation of synapse maturation (GO:0090129)2.09282127
182synaptic vesicle endocytosis (GO:0048488)2.08754200
183positive regulation of axon extension (GO:0045773)2.08147948
184cortical actin cytoskeleton organization (GO:0030866)2.08095379
185G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.07783828
186regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.07583212
187positive regulation of fatty acid beta-oxidation (GO:0032000)2.07428646
188cerebellar Purkinje cell layer development (GO:0021680)2.07384407
189nucleus localization (GO:0051647)2.06732792
190regulation of translational termination (GO:0006449)2.06621687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.62454788
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50627907
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11023727
4RUNX_20019798_ChIP-Seq_JUKART_Human2.76483263
5SCL_19346495_ChIP-Seq_HPC-7_Human2.70073754
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51220372
7EZH2_22144423_ChIP-Seq_EOC_Human2.47470689
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46686702
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37716990
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31608215
11MYB_26560356_Chip-Seq_TH2_Human2.29678649
12GATA1_22025678_ChIP-Seq_K562_Human2.28338124
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19857621
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15716432
15DROSHA_22980978_ChIP-Seq_HELA_Human2.09847340
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.08421951
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01567369
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.98944352
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.93720356
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88934985
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.86178521
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.85573681
23IGF1R_20145208_ChIP-Seq_DFB_Human1.84363713
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80966373
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80526741
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79507284
27MYB_26560356_Chip-Seq_TH1_Human1.79178641
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79082218
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77467263
30* GATA3_27048872_Chip-Seq_THYMUS_Human1.77278851
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72941007
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72452343
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72002310
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71639790
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71552469
36VDR_24787735_ChIP-Seq_THP-1_Human1.70875058
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.68013135
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67472510
39KDM2B_26808549_Chip-Seq_DND41_Human1.60236352
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60133156
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60093583
42KDM2B_26808549_Chip-Seq_K562_Human1.58765364
43SPI1_23547873_ChIP-Seq_NB4_Human1.57335867
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51503825
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50933700
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49300626
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.46842369
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.46650218
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.46538256
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45716914
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44661272
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41876183
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40309635
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39319100
55* GATA3_26560356_Chip-Seq_TH2_Human1.39145817
56CLOCK_20551151_ChIP-Seq_293T_Human1.38546100
57TP53_16413492_ChIP-PET_HCT116_Human1.38155119
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37972067
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.37841397
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.37370973
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36199894
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34729951
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34154126
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33628173
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.30867107
66AR_21572438_ChIP-Seq_LNCaP_Human1.30418041
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30387162
68GBX2_23144817_ChIP-Seq_PC3_Human1.29802025
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29746607
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.29339889
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29300398
72TAF15_26573619_Chip-Seq_HEK293_Human1.29191330
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28854969
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27646751
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27464913
76AR_19668381_ChIP-Seq_PC3_Human1.26711008
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.26623403
78VDR_24763502_ChIP-Seq_THP-1_Human1.24503679
79AHR_22903824_ChIP-Seq_MCF-7_Human1.24488379
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23861621
81SMAD4_21799915_ChIP-Seq_A2780_Human1.23803047
82TCF7_22412390_ChIP-Seq_EML_Mouse1.22681021
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.21306229
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20496393
85RXR_22108803_ChIP-Seq_LS180_Human1.17979921
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17904915
87STAT3_23295773_ChIP-Seq_U87_Human1.17744556
88CIITA_25753668_ChIP-Seq_RAJI_Human1.17328750
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17232066
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16957525
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16771451
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16362279
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15798956
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15623484
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15462331
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.14030714
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.14030714
98REST_21632747_ChIP-Seq_MESCs_Mouse1.13796409
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12094360
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11661457
101GATA2_19941826_ChIP-Seq_K562_Human1.11625918
102ER_23166858_ChIP-Seq_MCF-7_Human1.11581328
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11438303
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11174733
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.11018054
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10785625
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10785625
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10049487
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08514294
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07827193
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.06775436
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06769443
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06557488
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.06173823
115SPI1_23127762_ChIP-Seq_K562_Human1.05671964
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05136673
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04927578
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.04744882
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04315838
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03816600
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03217401
122PU_27001747_Chip-Seq_BMDM_Mouse1.03195202
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.03134234
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02752378
125MAF_26560356_Chip-Seq_TH1_Human1.01873073
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.00879468
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99894604
128SMRT_27268052_Chip-Seq_Bcells_Human0.99355200
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99278390
130BCAT_22108803_ChIP-Seq_LS180_Human0.99147494
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98912221
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.98856412
133GATA1_19941826_ChIP-Seq_K562_Human0.98165860
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.97200554
135ZNF274_21170338_ChIP-Seq_K562_Hela0.97105925
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97037959
137MYC_22102868_ChIP-Seq_BL_Human0.96972764
138* TCF4_23295773_ChIP-Seq_U87_Human0.96703754
139UTX_26944678_Chip-Seq_JUKART_Human0.96490408
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95669492
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.95231119
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93832134
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93301998
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.93274750
145GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93152171
146SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92317659
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91779496
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.91005535
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.90978284
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.90846914
151FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90591456
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.90571525
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89887052
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89263549
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88918422
156FUS_26573619_Chip-Seq_HEK293_Human0.88578989
157STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87767234
158GATA2_21666600_ChIP-Seq_HMVEC_Human0.87710597
159RNF2_27304074_Chip-Seq_ESCs_Mouse0.87659537
160GATA3_26560356_Chip-Seq_TH1_Human0.87303696
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87116336
162SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86999075
163DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86043755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.14868686
2MP0004859_abnormal_synaptic_plasticity4.28681034
3MP0002009_preneoplasia4.06086686
4MP0008057_abnormal_DNA_replication3.49583006
5MP0003705_abnormal_hypodermis_morpholog3.34447930
6MP0002396_abnormal_hematopoietic_system3.23111852
7MP0009780_abnormal_chondrocyte_physiolo3.22638178
8MP0003763_abnormal_thymus_physiology3.09358539
9MP0001835_abnormal_antigen_presentation2.88571682
10MP0002166_altered_tumor_susceptibility2.82011896
11MP0004130_abnormal_muscle_cell2.59303324
12MP0003724_increased_susceptibility_to2.56748710
13MP0010234_abnormal_vibrissa_follicle2.45043385
14MP0008438_abnormal_cutaneous_collagen2.39733182
15MP0004858_abnormal_nervous_system2.38821309
16MP0003045_fibrosis2.32174088
17MP0002837_dystrophic_cardiac_calcinosis2.32031283
18MP0001800_abnormal_humoral_immune2.25181335
19MP0008260_abnormal_autophagy2.23751189
20MP0002909_abnormal_adrenal_gland2.21098757
21MP0005623_abnormal_meninges_morphology2.18103733
22MP0000465_gastrointestinal_hemorrhage2.17564107
23MP0003635_abnormal_synaptic_transmissio2.15499711
24MP0004233_abnormal_muscle_weight2.11959114
25MP0010352_gastrointestinal_tract_polyps2.11370165
26MP0005076_abnormal_cell_differentiation2.04364395
27MP0003183_abnormal_peptide_metabolism2.01625598
28MP0003436_decreased_susceptibility_to1.98525666
29MP0001545_abnormal_hematopoietic_system1.97276761
30MP0005397_hematopoietic_system_phenotyp1.97276761
31MP0003300_gastrointestinal_ulcer1.93358809
32MP0005464_abnormal_platelet_physiology1.92420323
33MP0004808_abnormal_hematopoietic_stem1.88301673
34MP0002420_abnormal_adaptive_immunity1.83884823
35MP0002419_abnormal_innate_immunity1.83429583
36MP0003172_abnormal_lysosome_physiology1.82112586
37MP0002398_abnormal_bone_marrow1.80354950
38MP0001819_abnormal_immune_cell1.78813353
39MP0004084_abnormal_cardiac_muscle1.76737099
40MP0000751_myopathy1.76145287
41MP0002723_abnormal_immune_serum1.75610965
42MP0002006_tumorigenesis1.75050813
43MP0003091_abnormal_cell_migration1.74924636
44MP0005000_abnormal_immune_tolerance1.73986976
45MP0004510_myositis1.71264971
46MP0003656_abnormal_erythrocyte_physiolo1.68221028
47MP0002452_abnormal_antigen_presenting1.67003810
48MP0003329_amyloid_beta_deposits1.66998886
49MP0009046_muscle_twitch1.66236993
50MP0000015_abnormal_ear_pigmentation1.65259464
51MP0002063_abnormal_learning/memory/cond1.64972832
52MP0005075_abnormal_melanosome_morpholog1.64227581
53MP0000604_amyloidosis1.64101749
54MP0008961_abnormal_basal_metabolism1.63028818
55MP0005025_abnormal_response_to1.61063298
56MP0000013_abnormal_adipose_tissue1.55348962
57MP0008877_abnormal_DNA_methylation1.54331504
58MP0000703_abnormal_thymus_morphology1.54097875
59MP0000689_abnormal_spleen_morphology1.53724597
60MP0004270_analgesia1.52889029
61MP0002405_respiratory_system_inflammati1.52011879
62MP0000716_abnormal_immune_system1.51768873
63MP0010307_abnormal_tumor_latency1.50497646
64MP0003303_peritoneal_inflammation1.50492332
65MP0000003_abnormal_adipose_tissue1.48086612
66MP0005671_abnormal_response_to1.47459267
67MP0005387_immune_system_phenotype1.47394656
68MP0001790_abnormal_immune_system1.47394656
69MP0004185_abnormal_adipocyte_glucose1.45739554
70MP0003866_abnormal_defecation1.45286900
71MP0003566_abnormal_cell_adhesion1.44832983
72MP0005666_abnormal_adipose_tissue1.44566882
73MP0002722_abnormal_immune_system1.43293232
74MP0003828_pulmonary_edema1.40380989
75MP0004087_abnormal_muscle_fiber1.39047224
76MP0005375_adipose_tissue_phenotype1.34839552
77MP0008775_abnormal_heart_ventricle1.32680834
78MP0005310_abnormal_salivary_gland1.32534762
79MP0002064_seizures1.32424472
80MP0005174_abnormal_tail_pigmentation1.31668673
81MP0009745_abnormal_behavioral_response1.31330796
82MP0003646_muscle_fatigue1.31185060
83MP0004811_abnormal_neuron_physiology1.30921971
84MP0003690_abnormal_glial_cell1.24959113
85MP0002877_abnormal_melanocyte_morpholog1.24478646
86MP0005409_darkened_coat_color1.23874135
87MP0004215_abnormal_myocardial_fiber1.23820316
88MP0000685_abnormal_immune_system1.21611411
89MP0005670_abnormal_white_adipose1.21207076
90MP0002269_muscular_atrophy1.19666592
91MP0003279_aneurysm1.19183418
92MP0009278_abnormal_bone_marrow1.18834823
93MP0002429_abnormal_blood_cell1.18733370
94MP0003787_abnormal_imprinting1.18689612
95MP0010155_abnormal_intestine_physiology1.14742950
96MP0001986_abnormal_taste_sensitivity1.13624171
97MP0009785_altered_susceptibility_to1.12608021
98MP0001299_abnormal_eye_distance/1.12234107
99MP0004381_abnormal_hair_follicle1.12154029
100MP0003075_altered_response_to1.11731221
101MP0004924_abnormal_behavior1.11056365
102MP0005386_behavior/neurological_phenoty1.11056365
103MP0004036_abnormal_muscle_relaxation1.10155424
104MP0005275_abnormal_skin_tensile1.07498077
105MP0010630_abnormal_cardiac_muscle1.06127992
106MP0001851_eye_inflammation1.05486644
107MP0002572_abnormal_emotion/affect_behav1.05242694
108MP0006138_congestive_heart_failure1.05240602
109MP0005187_abnormal_penis_morphology1.02323024
110MP0003191_abnormal_cellular_cholesterol1.01767992
111MP0001348_abnormal_lacrimal_gland0.99961343
112MP0003633_abnormal_nervous_system0.98597838
113MP0002090_abnormal_vision0.98422234
114MP0001968_abnormal_touch/_nociception0.96783759
115MP0004883_abnormal_blood_vessel0.95940735
116MP0008569_lethality_at_weaning0.95032121
117MP0001845_abnormal_inflammatory_respons0.94085002
118MP0002972_abnormal_cardiac_muscle0.94068946
119MP0002971_abnormal_brown_adipose0.93716578
120MP0001501_abnormal_sleep_pattern0.93630935
121MP0004947_skin_inflammation0.91793529
122MP0002168_other_aberrant_phenotype0.90989313
123MP0003943_abnormal_hepatobiliary_system0.90376672
124MP0005385_cardiovascular_system_phenoty0.90239866
125MP0001544_abnormal_cardiovascular_syste0.90239866
126MP0005330_cardiomyopathy0.88619552
127MP0000747_muscle_weakness0.86809024
128MP0000733_abnormal_muscle_development0.85711432
129MP0001849_ear_inflammation0.84667556
130MP0003122_maternal_imprinting0.82782855
131MP0003283_abnormal_digestive_organ0.82449810
132MP0005535_abnormal_body_temperature0.81653005
133MP0003631_nervous_system_phenotype0.81469038
134MP0005220_abnormal_exocrine_pancreas0.81313811
135MP0004085_abnormal_heartbeat0.80395464
136MP0005620_abnormal_muscle_contractility0.79089239
137MP0003868_abnormal_feces_composition0.78470944
138MP0000427_abnormal_hair_cycle0.78135830
139MP0005058_abnormal_lysosome_morphology0.78027338
140MP0008995_early_reproductive_senescence0.77989970
141MP0002733_abnormal_thermal_nociception0.76963670
142MP0005621_abnormal_cell_physiology0.76591810
143MP0003632_abnormal_nervous_system0.76588320
144MP0001958_emphysema0.75848653
145MP0001177_atelectasis0.74704127
146MP0003634_abnormal_glial_cell0.74329690
147MP0004272_abnormal_basement_membrane0.74173803
148MP0008874_decreased_physiological_sensi0.74130132
149MP0001853_heart_inflammation0.73312364
150MP0008004_abnormal_stomach_pH0.72856591
151MP0009115_abnormal_fat_cell0.71230874
152MP0000759_abnormal_skeletal_muscle0.70956535
153MP0004134_abnormal_chest_morphology0.70820702
154MP0004264_abnormal_extraembryonic_tissu0.70749936
155MP0002896_abnormal_bone_mineralization0.70563072
156MP0000371_diluted_coat_color0.70375561
157MP0002734_abnormal_mechanical_nocicepti0.69309246
158MP0003121_genomic_imprinting0.69189370
159MP0005647_abnormal_sex_gland0.68990671
160MP0003221_abnormal_cardiomyocyte_apopto0.68284066
161MP0004484_altered_response_of0.68000398
162MP0002019_abnormal_tumor_incidence0.67995628
163MP0001533_abnormal_skeleton_physiology0.67487261
164MP0000955_abnormal_spinal_cord0.67313842
165MP0002108_abnormal_muscle_morphology0.66912531
166MP0003252_abnormal_bile_duct0.66896155
167MP0009703_decreased_birth_body0.66711361
168MP0001440_abnormal_grooming_behavior0.66106560
169MP0010678_abnormal_skin_adnexa0.64696553
170MP0002078_abnormal_glucose_homeostasis0.64660396
171MP0001915_intracranial_hemorrhage0.63814488
172MP0009672_abnormal_birth_weight0.63765810
173MP0002095_abnormal_skin_pigmentation0.63024201
174MP0002148_abnormal_hypersensitivity_rea0.62900644
175MP0001765_abnormal_ion_homeostasis0.61858719
176MP0002693_abnormal_pancreas_physiology0.60910611
177MP0002998_abnormal_bone_remodeling0.59063730
178MP0001873_stomach_inflammation0.58575003
179MP0008469_abnormal_protein_level0.57555368
180MP0005645_abnormal_hypothalamus_physiol0.55779441
181MP0002332_abnormal_exercise_endurance0.55680403
182MP0000383_abnormal_hair_follicle0.55537645

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)3.74073584
2Recurrent bacterial skin infections (HP:0005406)3.55877105
3Eczematoid dermatitis (HP:0000976)3.54601236
4Cerebral aneurysm (HP:0004944)3.51844444
5Panhypogammaglobulinemia (HP:0003139)3.46408239
6Agammaglobulinemia (HP:0004432)3.40761902
7Macroorchidism (HP:0000053)3.38400807
8Recurrent abscess formation (HP:0002722)3.30061076
9T lymphocytopenia (HP:0005403)3.27996613
10Colitis (HP:0002583)3.27710724
11Recurrent fungal infections (HP:0002841)3.26698647
12Viral hepatitis (HP:0006562)3.25890003
13Chronic mucocutaneous candidiasis (HP:0002728)3.23616095
14Recurrent cutaneous fungal infections (HP:0011370)3.23616095
15Elevated erythrocyte sedimentation rate (HP:0003565)3.12537521
16Recurrent viral infections (HP:0004429)3.09602304
17Acute myeloid leukemia (HP:0004808)3.09510324
18Dysmetric saccades (HP:0000641)3.08875844
19Abnormality of T cell number (HP:0011839)3.04707556
20Papilledema (HP:0001085)2.98222999
21Autoimmune hemolytic anemia (HP:0001890)2.93789214
22Prolonged bleeding time (HP:0003010)2.91931233
23Inflammation of the large intestine (HP:0002037)2.83351650
24Abnormality of the lower motor neuron (HP:0002366)2.78985358
25Gastrointestinal inflammation (HP:0004386)2.76567556
26Recurrent skin infections (HP:0001581)2.74297489
27Spontaneous hematomas (HP:0007420)2.71817858
28Stomach cancer (HP:0012126)2.70598176
29Neonatal hypoglycemia (HP:0001998)2.69559387
30Upper limb amyotrophy (HP:0009129)2.66357521
31Distal upper limb amyotrophy (HP:0007149)2.66357521
32Hand muscle atrophy (HP:0009130)2.61832226
33Acute lymphatic leukemia (HP:0006721)2.61425137
34Termporal pattern (HP:0011008)2.59192157
35Insidious onset (HP:0003587)2.59192157
36Hyperacusis (HP:0010780)2.58867526
37Subacute progressive viral hepatitis (HP:0006572)2.58501496
38Gingival bleeding (HP:0000225)2.57648071
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57178785
40Action tremor (HP:0002345)2.56240378
41Stomatitis (HP:0010280)2.53282409
42Meningitis (HP:0001287)2.51602312
43Chest pain (HP:0100749)2.50585668
44Recurrent gram-negative bacterial infections (HP:0005420)2.48115628
45Neoplasm of the tracheobronchial system (HP:0100552)2.46904218
46Aneurysm (HP:0002617)2.46306330
47Shallow orbits (HP:0000586)2.45491092
48Hyperventilation (HP:0002883)2.44197847
49Abnormality of T cells (HP:0002843)2.44076004
50Focal seizures (HP:0007359)2.43675422
51Cellulitis (HP:0100658)2.39990441
52Dilatation of the ascending aorta (HP:0005111)2.39417035
53Periodontitis (HP:0000704)2.37705656
54Gastrointestinal infarctions (HP:0005244)2.37558209
55Resting tremor (HP:0002322)2.36301106
56Gingivitis (HP:0000230)2.35735789
57Myositis (HP:0100614)2.35373696
58Hemiplegia (HP:0002301)2.33855076
59Osteomyelitis (HP:0002754)2.32333999
60Recurrent bronchitis (HP:0002837)2.31526634
61Heterotopia (HP:0002282)2.29395849
62Enlarged penis (HP:0000040)2.28390988
63Increased IgE level (HP:0003212)2.27523547
64Leukocytosis (HP:0001974)2.26355827
65Granulocytopenia (HP:0001913)2.26256184
66Widely spaced teeth (HP:0000687)2.25913716
67Thyroiditis (HP:0100646)2.24979865
68Epistaxis (HP:0000421)2.24396113
69Lymphangioma (HP:0100764)2.24375701
70Hyporeflexia of lower limbs (HP:0002600)2.23382534
71Fair hair (HP:0002286)2.23241361
72Abnormality of T cell physiology (HP:0011840)2.22422381
73Bowel diverticulosis (HP:0005222)2.21374228
74Supranuclear gaze palsy (HP:0000605)2.21331845
75Difficulty running (HP:0009046)2.20493460
76Vasculitis (HP:0002633)2.20096066
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19935803
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.19935803
79Urinary bladder sphincter dysfunction (HP:0002839)2.19767031
80Chronic diarrhea (HP:0002028)2.19627266
81IgM deficiency (HP:0002850)2.19459795
82Mitral valve prolapse (HP:0001634)2.16840116
83Aortic aneurysm (HP:0004942)2.15900774
84Myokymia (HP:0002411)2.15675150
85Ankle contracture (HP:0006466)2.14883892
86Mediastinal lymphadenopathy (HP:0100721)2.13750377
87Absent frontal sinuses (HP:0002688)2.12174621
88Alveolar cell carcinoma (HP:0006519)2.11995716
89Generalized hypopigmentation of hair (HP:0011358)2.11942521
90Postural instability (HP:0002172)2.11535519
91Striae distensae (HP:0001065)2.10443351
92Lower limb amyotrophy (HP:0007210)2.10278575
93Pointed chin (HP:0000307)2.09587155
94Abnormality of the prostate (HP:0008775)2.09479085
95Visual hallucinations (HP:0002367)2.09129385
96Amyotrophic lateral sclerosis (HP:0007354)2.07806126
97Genetic anticipation (HP:0003743)2.07449103
98Spondylolisthesis (HP:0003302)2.07350244
99Abnormality of eosinophils (HP:0001879)2.07065351
100Protrusio acetabuli (HP:0003179)2.05212160
101Hamartoma of the eye (HP:0010568)2.04696403
102Eosinophilia (HP:0001880)2.04333801
103Bladder diverticulum (HP:0000015)2.04084605
104Glucose intolerance (HP:0000833)2.04047515
105Narrow palate (HP:0000189)1.98164934
106Elfin facies (HP:0004428)1.98108694
107Papilloma (HP:0012740)1.97442149
108Verrucae (HP:0200043)1.97442149
109Abnormal hair whorl (HP:0010721)1.97425436
110Abnormality of B cell number (HP:0010975)1.95701613
111Impaired vibration sensation in the lower limbs (HP:0002166)1.95573587
112Astrocytoma (HP:0009592)1.95469754
113Abnormality of the astrocytes (HP:0100707)1.95469754
114Abnormal social behavior (HP:0012433)1.94958724
115Impaired social interactions (HP:0000735)1.94958724
116Insomnia (HP:0100785)1.94472373
117Impaired smooth pursuit (HP:0007772)1.94395518
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92319739
119Short 4th metacarpal (HP:0010044)1.92319739
120Abnormality of the corticospinal tract (HP:0002492)1.91889586
121Curly hair (HP:0002212)1.91690373
122Encephalitis (HP:0002383)1.91391831
123Cortical dysplasia (HP:0002539)1.90615461
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90431580
125Bundle branch block (HP:0011710)1.89569576
126Thrombocytosis (HP:0001894)1.88595011
127Abnormality of ocular smooth pursuit (HP:0000617)1.88480753
128Neoplasm of the heart (HP:0100544)1.88431946
129Renovascular hypertension (HP:0100817)1.87972073
130Frequent falls (HP:0002359)1.87794805
131Fibrous tissue neoplasm (HP:0012316)1.86357325
132Severe combined immunodeficiency (HP:0004430)1.85951067
133Urinary urgency (HP:0000012)1.85446536
134Fibroma (HP:0010614)1.84721232
135Abnormality of the fingertips (HP:0001211)1.84657371
136Long toe (HP:0010511)1.84567191
137Truncal ataxia (HP:0002078)1.84215483
138Vascular tortuosity (HP:0004948)1.83361569
139Acute hepatic failure (HP:0006554)1.83071443
140Gaze-evoked nystagmus (HP:0000640)1.83015555
141Ankyloglossia (HP:0010296)1.82900842
142Arterial tortuosity (HP:0005116)1.82524685
143Hemoptysis (HP:0002105)1.82398951
144Genu recurvatum (HP:0002816)1.82192734
145Abnormality of oral frenula (HP:0000190)1.81867524
146Thyroid carcinoma (HP:0002890)1.81355759
147Pulmonary infiltrates (HP:0002113)1.79707623
148Papillary thyroid carcinoma (HP:0002895)1.79506471
149Hepatitis (HP:0012115)1.79399031
150Increased variability in muscle fiber diameter (HP:0003557)1.78064711
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77769480
152Abnormal glucose tolerance (HP:0001952)1.77307474
153Volvulus (HP:0002580)1.77165331
154Depression (HP:0000716)1.75153914
155Fatigue (HP:0012378)1.74787188
156Hypercortisolism (HP:0001578)1.74758413
157Testicular neoplasm (HP:0010788)1.74554881
158Impaired vibratory sensation (HP:0002495)1.74295007
159Chronic obstructive pulmonary disease (HP:0006510)1.74167706
160Obstructive lung disease (HP:0006536)1.74167706
161Dysdiadochokinesis (HP:0002075)1.73572403
162Tapered finger (HP:0001182)1.73099202
163Thickened calvaria (HP:0002684)1.72432241
164Hematochezia (HP:0002573)1.71991382
165Vertebral arch anomaly (HP:0008438)1.71750741
166Pustule (HP:0200039)1.71698694
167Protruding tongue (HP:0010808)1.71328549
168Abnormality of the 4th metacarpal (HP:0010012)1.70944476
169Excessive salivation (HP:0003781)1.70765609
170Drooling (HP:0002307)1.70765609
171Broad metatarsal (HP:0001783)1.69460782
172Intellectual disability, profound (HP:0002187)1.67322295
173Sudden death (HP:0001699)1.64506836
174Progressive cerebellar ataxia (HP:0002073)1.62419111
175Cerebral inclusion bodies (HP:0100314)1.62038571
176Ventricular fibrillation (HP:0001663)1.61840509
177Pheochromocytoma (HP:0002666)1.61069860
178Poor eye contact (HP:0000817)1.60816681
179Neoplasm of the adrenal cortex (HP:0100641)1.59913836
180Focal motor seizures (HP:0011153)1.59415676
181Cervical subluxation (HP:0003308)1.58573626
182Central scotoma (HP:0000603)1.58548565
183Inappropriate behavior (HP:0000719)1.57757042
184Hypoventilation (HP:0002791)1.57318327
185Lower limb asymmetry (HP:0100559)1.56652178
186Exostoses (HP:0100777)1.56495812
187Aortic dissection (HP:0002647)1.53567184
188Obsessive-compulsive behavior (HP:0000722)1.52174444
189Lower limb muscle weakness (HP:0007340)1.51615966
190Turricephaly (HP:0000262)1.49711368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.42269333
2MAP3K93.07276090
3PKN22.77749801
4MAP4K12.59614918
5TAOK32.52224287
6TEC2.38603344
7NTRK32.29943449
8PRKD32.15076410
9MAP3K42.09057011
10CDK122.05481479
11BTK2.03126319
12CAMK1D2.00642038
13BRD41.96578031
14CAMK1G1.96160811
15TNK21.88592937
16KSR21.84334253
17ITK1.80984080
18EEF2K1.80388783
19PRPF4B1.79649905
20SCYL21.78962423
21PAK61.78585832
22TTN1.78476097
23BMPR21.73985068
24RIPK11.72202942
25PDGFRA1.68591289
26SYK1.67326819
27BLK1.65369983
28LMTK21.61379221
29CSF1R1.60722267
30SIK11.58585723
31MAP3K141.57407513
32MARK11.56041007
33RET1.55216561
34IKBKE1.53271096
35NTRK11.53030658
36KIT1.50872689
37LATS11.46672107
38CAMKK11.46538186
39PIK3CG1.45557840
40HCK1.43247433
41MAP3K101.42583150
42MINK11.42044795
43TXK1.40532481
44ZAP701.39311507
45AKT31.35441445
46TRPM71.34468725
47NTRK21.33744189
48ICK1.33513180
49SGK31.32201370
50DAPK21.30774118
51PRKCH1.30377346
52PDK41.30316870
53PDK31.30316870
54MAP3K21.28394731
55GRK61.25338974
56LATS21.25338353
57JAK11.23150588
58EPHA31.22595089
59STK381.21886636
60LCK1.18662372
61TYRO31.18187947
62ALK1.17086975
63NLK1.14274463
64NEK11.13723818
65FGFR31.13243560
66YES11.06395264
67PTK61.05235860
68EPHA41.04175341
69LYN1.04169246
70MAP2K41.02402371
71SIK21.02033862
72WNK11.01166503
73PAK31.00314087
74TBK10.99669624
75MAP2K30.98887773
76PDGFRB0.97019609
77FGFR20.96659078
78MTOR0.95740045
79SGK20.91616461
80CSK0.91212909
81RAF10.89372968
82FRK0.88764898
83BMX0.88213567
84PHKG10.85847902
85PHKG20.85847902
86MAP3K60.85689257
87NEK60.85314929
88KSR10.85072419
89PDK10.84743152
90ACVR1B0.83600975
91CDK50.83208156
92DMPK0.83102705
93STK240.80676421
94STK110.78486237
95ERBB30.77843802
96DDR20.77339091
97PRKCQ0.77002076
98CDC42BPA0.76957196
99MAPK70.73216852
100PIK3CA0.72748291
101PDPK10.70436982
102PIM10.70188539
103MAPK120.69039346
104IRAK10.68924665
105EIF2AK30.68693761
106SGK10.68512427
107LRRK20.68370798
108MAP3K70.66626732
109MAP3K130.66214817
110TAOK10.65673507
111IKBKB0.64422982
112JAK20.64044871
113RPS6KA20.62113327
114PASK0.61959285
115IRAK40.61761215
116ERN10.61064061
117TGFBR20.60960425
118SGK2230.59802356
119SGK4940.59802356
120FES0.59599919
121NUAK10.59548116
122FGFR40.59232292
123JAK30.58153464
124PRKAA10.58010171
125PRKAA20.57782402
126PLK20.57719090
127CDK60.57597200
128FER0.57344492
129PTK20.56102667
130RPS6KB10.55378314
131ROCK10.54942514
132RIPK40.54553827
133CDK90.54141682
134RPS6KA30.52712890
135FGR0.52240176
136CDK40.52013192
137PRKD10.50939400
138FLT30.49152576
139MAP3K10.48993851
140MAPK100.47595483
141ABL10.46996535
142EPHB10.46185013
143PTK2B0.45854352
144CDK30.45643939
145FGFR10.45619735
146HIPK20.44734431
147FYN0.44477456
148MARK20.42212619
149PDK20.41404237
150CSNK1D0.41236726
151CAMK40.41126167
152PAK20.40970991
153DAPK10.40941525
154STK30.40155921
155MAP3K50.40047264
156TYK20.39959151
157EGFR0.39331355
158CAMKK20.38979108

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053401.98054157
2T cell receptor signaling pathway_Homo sapiens_hsa046601.95897223
3Leishmaniasis_Homo sapiens_hsa051401.89317163
4Nitrogen metabolism_Homo sapiens_hsa009101.82702562
5Acute myeloid leukemia_Homo sapiens_hsa052211.80118863
6Type II diabetes mellitus_Homo sapiens_hsa049301.75682182
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69401535
8Long-term potentiation_Homo sapiens_hsa047201.55675525
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52243750
10mTOR signaling pathway_Homo sapiens_hsa041501.51543145
11Type I diabetes mellitus_Homo sapiens_hsa049401.50786367
12Synaptic vesicle cycle_Homo sapiens_hsa047211.50149289
13Glioma_Homo sapiens_hsa052141.49838246
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48080502
15Allograft rejection_Homo sapiens_hsa053301.43161547
16Autoimmune thyroid disease_Homo sapiens_hsa053201.42415998
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41598161
18Graft-versus-host disease_Homo sapiens_hsa053321.39846147
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.39759914
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38097735
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37530980
22Olfactory transduction_Homo sapiens_hsa047401.35544321
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35472559
24Measles_Homo sapiens_hsa051621.34989644
25Dorso-ventral axis formation_Homo sapiens_hsa043201.34699330
26Circadian entrainment_Homo sapiens_hsa047131.34664429
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33811957
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32464112
29Staphylococcus aureus infection_Homo sapiens_hsa051501.30600358
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30006891
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29814299
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29647433
33Circadian rhythm_Homo sapiens_hsa047101.28036095
34Estrogen signaling pathway_Homo sapiens_hsa049151.27255185
35Tuberculosis_Homo sapiens_hsa051521.26858900
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26638666
37Dilated cardiomyopathy_Homo sapiens_hsa054141.25421654
38Gastric acid secretion_Homo sapiens_hsa049711.22716461
39Renin secretion_Homo sapiens_hsa049241.22403835
40Insulin secretion_Homo sapiens_hsa049111.21408246
41Dopaminergic synapse_Homo sapiens_hsa047281.18691866
42GABAergic synapse_Homo sapiens_hsa047271.17489713
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.17083435
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16572526
45Salivary secretion_Homo sapiens_hsa049701.16241367
46Asthma_Homo sapiens_hsa053101.16132594
47Cholinergic synapse_Homo sapiens_hsa047251.15712070
48Hematopoietic cell lineage_Homo sapiens_hsa046401.15679092
49Chronic myeloid leukemia_Homo sapiens_hsa052201.13959701
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13905299
51Insulin resistance_Homo sapiens_hsa049311.13328134
52Glutamatergic synapse_Homo sapiens_hsa047241.11959478
53Influenza A_Homo sapiens_hsa051641.11656672
54Regulation of autophagy_Homo sapiens_hsa041401.08548356
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07964219
56Morphine addiction_Homo sapiens_hsa050321.07778573
57Fatty acid biosynthesis_Homo sapiens_hsa000611.07554844
58Other glycan degradation_Homo sapiens_hsa005111.06611328
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.06332631
60Oxytocin signaling pathway_Homo sapiens_hsa049211.05935396
61Endometrial cancer_Homo sapiens_hsa052131.05564397
62Glucagon signaling pathway_Homo sapiens_hsa049221.05207156
63Hepatitis B_Homo sapiens_hsa051611.05085501
64Amphetamine addiction_Homo sapiens_hsa050311.04905425
65Insulin signaling pathway_Homo sapiens_hsa049101.04523397
66Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04223478
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.02551901
68Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01311138
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01019719
70Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00489983
71GnRH signaling pathway_Homo sapiens_hsa049121.00425495
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99826593
73Non-small cell lung cancer_Homo sapiens_hsa052230.99618884
74ErbB signaling pathway_Homo sapiens_hsa040120.97479922
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.97113813
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.97102792
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.97033275
78Focal adhesion_Homo sapiens_hsa045100.96813160
79Nicotine addiction_Homo sapiens_hsa050330.96762519
80cAMP signaling pathway_Homo sapiens_hsa040240.96258632
81Herpes simplex infection_Homo sapiens_hsa051680.94262777
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.93785332
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93669995
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93126417
85AMPK signaling pathway_Homo sapiens_hsa041520.92000315
86Gap junction_Homo sapiens_hsa045400.91006325
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90975108
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.90670113
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89511813
90Proteoglycans in cancer_Homo sapiens_hsa052050.89407711
91Lysine degradation_Homo sapiens_hsa003100.89155297
92Cocaine addiction_Homo sapiens_hsa050300.88295698
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88124431
94Amoebiasis_Homo sapiens_hsa051460.86694186
95Pancreatic cancer_Homo sapiens_hsa052120.86470505
96Antigen processing and presentation_Homo sapiens_hsa046120.85791747
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84567124
98Colorectal cancer_Homo sapiens_hsa052100.83769132
99VEGF signaling pathway_Homo sapiens_hsa043700.83659398
100Viral myocarditis_Homo sapiens_hsa054160.80791612
101TNF signaling pathway_Homo sapiens_hsa046680.78831713
102Hepatitis C_Homo sapiens_hsa051600.77888125
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76333515
104Renal cell carcinoma_Homo sapiens_hsa052110.75378649
105Long-term depression_Homo sapiens_hsa047300.74731039
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74324614
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71585390
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70654324
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69965326
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69504346
111Calcium signaling pathway_Homo sapiens_hsa040200.69460192
112Thyroid hormone synthesis_Homo sapiens_hsa049180.69225747
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68638137
114Platelet activation_Homo sapiens_hsa046110.68052538
115Prolactin signaling pathway_Homo sapiens_hsa049170.67732562
116Legionellosis_Homo sapiens_hsa051340.67085636
117Choline metabolism in cancer_Homo sapiens_hsa052310.66859793
118Adherens junction_Homo sapiens_hsa045200.66372519
119Prostate cancer_Homo sapiens_hsa052150.66365280
120Bile secretion_Homo sapiens_hsa049760.64989144
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.64717551
122Inositol phosphate metabolism_Homo sapiens_hsa005620.64268804
123Toxoplasmosis_Homo sapiens_hsa051450.64245554
124MAPK signaling pathway_Homo sapiens_hsa040100.62666364
125Melanogenesis_Homo sapiens_hsa049160.61895488
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61894469
127B cell receptor signaling pathway_Homo sapiens_hsa046620.61631069
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61570311
129Pancreatic secretion_Homo sapiens_hsa049720.61398006
130Endocytosis_Homo sapiens_hsa041440.60745655
131Osteoclast differentiation_Homo sapiens_hsa043800.60407345
132Chemokine signaling pathway_Homo sapiens_hsa040620.59700835
133Rap1 signaling pathway_Homo sapiens_hsa040150.59309814
134HIF-1 signaling pathway_Homo sapiens_hsa040660.59020914
135Oocyte meiosis_Homo sapiens_hsa041140.59003474
136ABC transporters_Homo sapiens_hsa020100.58738770
137Arginine biosynthesis_Homo sapiens_hsa002200.58411235
138Shigellosis_Homo sapiens_hsa051310.58021632
139Viral carcinogenesis_Homo sapiens_hsa052030.57267547
140FoxO signaling pathway_Homo sapiens_hsa040680.56692854
141PPAR signaling pathway_Homo sapiens_hsa033200.55611751
142Phagosome_Homo sapiens_hsa041450.54895991
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54792751
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52602415
145Non-homologous end-joining_Homo sapiens_hsa034500.51754238
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48973455
147Malaria_Homo sapiens_hsa051440.45588308

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