HEATR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)6.03639420
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.80910707
3superoxide anion generation (GO:0042554)4.43921753
4response to muramyl dipeptide (GO:0032495)4.10948901
5vagina development (GO:0060068)3.95460200
6histone H3-K4 trimethylation (GO:0080182)3.87864240
7hepatocyte apoptotic process (GO:0097284)3.85897662
8positive regulation of keratinocyte differentiation (GO:0045618)3.78884143
9regulation of centrosome duplication (GO:0010824)3.78811816
10viral mRNA export from host cell nucleus (GO:0046784)3.66048363
11modulation by virus of host process (GO:0019054)3.54722070
12regulation of centrosome cycle (GO:0046605)3.54531132
13response to peptidoglycan (GO:0032494)3.54160107
14kinetochore organization (GO:0051383)3.53878465
15embryonic camera-type eye morphogenesis (GO:0048596)3.46205451
16regulation of establishment of cell polarity (GO:2000114)3.44126521
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41324949
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.41324949
19modulation by symbiont of host immune response (GO:0052553)3.41324949
20positive regulation by symbiont of host defense response (GO:0052509)3.41324949
21modulation by symbiont of host defense response (GO:0052031)3.41324949
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41324949
23nuclear pore complex assembly (GO:0051292)3.40641137
24female genitalia development (GO:0030540)3.40484627
25kinetochore assembly (GO:0051382)3.40406843
26negative regulation of organelle assembly (GO:1902116)3.40091571
27regulation of establishment or maintenance of cell polarity (GO:0032878)3.37720570
28mesonephros development (GO:0001823)3.21227485
29tolerance induction (GO:0002507)3.20859524
30regulation of cell proliferation involved in kidney development (GO:1901722)3.20458496
31prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.19725681
32histone H3-K4 methylation (GO:0051568)3.13482363
33positive regulation of translational initiation (GO:0045948)3.12783839
34cellular response to exogenous dsRNA (GO:0071360)3.11716115
35replication fork processing (GO:0031297)3.11705976
36striated muscle atrophy (GO:0014891)3.06653662
37nuclear pore organization (GO:0006999)3.04718275
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.03186773
39cardiac right ventricle morphogenesis (GO:0003215)3.02457436
40mitotic sister chromatid cohesion (GO:0007064)3.02248496
41DNA strand renaturation (GO:0000733)3.02224504
42histamine secretion (GO:0001821)2.97443780
43maturation of SSU-rRNA (GO:0030490)2.97194570
44positive regulation of gamma-delta T cell activation (GO:0046645)2.96353484
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95339036
46negative regulation of DNA repair (GO:0045738)2.94504644
47TOR signaling (GO:0031929)2.93670624
48modulation by symbiont of host cellular process (GO:0044068)2.93395266
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.93313096
50meiotic chromosome segregation (GO:0045132)2.93090119
51peptidyl-arginine omega-N-methylation (GO:0035247)2.92466636
52ER overload response (GO:0006983)2.88499070
53muscle atrophy (GO:0014889)2.88157200
54biotin metabolic process (GO:0006768)2.87538285
55DNA strand elongation (GO:0022616)2.86913719
56DNA synthesis involved in DNA repair (GO:0000731)2.85727191
57neutrophil activation involved in immune response (GO:0002283)2.85564386
58neutrophil activation (GO:0042119)2.83287506
59negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.77437090
60embryonic eye morphogenesis (GO:0048048)2.77291604
61regulation of double-strand break repair via homologous recombination (GO:0010569)2.76826498
62limb bud formation (GO:0060174)2.76373832
63spliceosomal tri-snRNP complex assembly (GO:0000244)2.75880087
64sympathetic nervous system development (GO:0048485)2.74939571
65uterus development (GO:0060065)2.73137553
66DNA strand elongation involved in DNA replication (GO:0006271)2.73132201
67peptidyl-arginine methylation (GO:0018216)2.71669989
68peptidyl-arginine N-methylation (GO:0035246)2.71669989
69regulation of vitamin D biosynthetic process (GO:0060556)2.71656954
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.71266336
71skeletal muscle adaptation (GO:0043501)2.68992004
72DNA geometric change (GO:0032392)2.68848020
73ear development (GO:0043583)2.67698666
74DNA duplex unwinding (GO:0032508)2.66907815
75histone arginine methylation (GO:0034969)2.65842607
76histone H3-K36 demethylation (GO:0070544)2.63188242
77regulation of mesenchymal cell apoptotic process (GO:2001053)2.61218001
78negative regulation of telomere maintenance (GO:0032205)2.59890207
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58207844
80regulation of DNA endoreduplication (GO:0032875)2.58089847
81intestinal epithelial cell development (GO:0060576)2.56620452
82DNA replication checkpoint (GO:0000076)2.56397625
83positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.55561309
84positive regulation of cell cycle G2/M phase transition (GO:1902751)2.55561309
85neutrophil mediated immunity (GO:0002446)2.54940372
86positive regulation of interferon-alpha production (GO:0032727)2.53345536
87respiratory burst (GO:0045730)2.53162984
88response to host immune response (GO:0052572)2.51511787
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51511787
90positive regulation of defense response to virus by host (GO:0002230)2.51093331
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50922344
92defense response to protozoan (GO:0042832)2.50876271
93granulocyte activation (GO:0036230)2.50541630
94leukocyte aggregation (GO:0070486)2.49636306
95regulation of histone H3-K27 methylation (GO:0061085)2.49491303
96glucose 6-phosphate metabolic process (GO:0051156)2.48383218
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.47686133
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.47254843
99pore complex assembly (GO:0046931)2.47031753
100microtubule depolymerization (GO:0007019)2.46788746
101base-excision repair (GO:0006284)2.44584420
102regulation of B cell receptor signaling pathway (GO:0050855)2.44121174
103DNA ligation (GO:0006266)2.44076785
104regulation of helicase activity (GO:0051095)2.43140223
105protein-DNA complex disassembly (GO:0032986)2.42953376
106nucleosome disassembly (GO:0006337)2.42953376
107negative regulation of interleukin-12 production (GO:0032695)2.42637975
108regulation of RIG-I signaling pathway (GO:0039535)2.42487185
109positive regulation of epidermal cell differentiation (GO:0045606)2.41203589
110DNA unwinding involved in DNA replication (GO:0006268)2.41153126
111telomere maintenance via telomerase (GO:0007004)2.40259593
112zinc ion transmembrane transport (GO:0071577)2.40170268
113mitotic recombination (GO:0006312)2.40019249
114superoxide metabolic process (GO:0006801)2.39489891
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38719907
116poly(A)+ mRNA export from nucleus (GO:0016973)2.38702974
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.38498786
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38498786
119mitotic chromosome condensation (GO:0007076)2.38255145
120chromatin remodeling at centromere (GO:0031055)2.38104548
121regulation of vitamin metabolic process (GO:0030656)2.37854326
122regulation of interferon-alpha production (GO:0032647)2.37473767
123DNA replication-dependent nucleosome organization (GO:0034723)2.37021349
124DNA replication-dependent nucleosome assembly (GO:0006335)2.37021349
125nucleobase biosynthetic process (GO:0046112)2.36988017
126DNA replication initiation (GO:0006270)2.36977628
127negative regulation of growth of symbiont in host (GO:0044130)2.36888737
128negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.36888737
129modulation of growth of symbiont involved in interaction with host (GO:0044144)2.36888737
130regulation of growth of symbiont in host (GO:0044126)2.36888737
131reactive oxygen species biosynthetic process (GO:1903409)2.36747483
132branching involved in prostate gland morphogenesis (GO:0060442)2.36628190
133pre-miRNA processing (GO:0031054)2.35793285
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34633535
135sister chromatid segregation (GO:0000819)2.34332216
136DNA double-strand break processing (GO:0000729)2.34151630
137base-excision repair, AP site formation (GO:0006285)2.34030496
138immunoglobulin mediated immune response (GO:0016064)2.33577196
139lens fiber cell development (GO:0070307)2.33184568
140RNA-dependent DNA replication (GO:0006278)2.32501120
141peptidyl-threonine dephosphorylation (GO:0035970)2.31805284
142mRNA export from nucleus (GO:0006406)2.30927331
143mitotic sister chromatid segregation (GO:0000070)2.30296200
144CENP-A containing nucleosome assembly (GO:0034080)2.30284869
145regulation of histone H3-K4 methylation (GO:0051569)2.29933268
146RNA export from nucleus (GO:0006405)2.29155686
147B cell receptor signaling pathway (GO:0050853)2.29069043
148histone H4-K12 acetylation (GO:0043983)2.27536015
149establishment of chromosome localization (GO:0051303)2.26985772
150resolution of meiotic recombination intermediates (GO:0000712)2.26976205
151termination of RNA polymerase II transcription (GO:0006369)2.26843155
152negative regulation of mast cell activation (GO:0033004)2.25308834
153regulation of superoxide anion generation (GO:0032928)2.25147771
154DNA-dependent DNA replication (GO:0006261)2.23960231
155telomere maintenance via recombination (GO:0000722)2.23520741
156positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23443533
157regulation of hippo signaling (GO:0035330)2.23073025
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.22706280
159regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.22690638
160peptidyl-histidine modification (GO:0018202)2.22063042
161pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.21841339
162mitotic nuclear envelope disassembly (GO:0007077)2.21066320
163positive regulation of alpha-beta T cell proliferation (GO:0046641)2.20941333
164lipopolysaccharide biosynthetic process (GO:0009103)2.20870994
165regulation of alpha-beta T cell proliferation (GO:0046640)2.20626757
166positive regulation of interferon-gamma production (GO:0032729)2.20407200
167T cell migration (GO:0072678)2.20298763
168telomere maintenance via semi-conservative replication (GO:0032201)2.20259639
169positive regulation of interleukin-1 beta secretion (GO:0050718)2.20088966
170positive regulation of DNA recombination (GO:0045911)2.19715725
171vitamin catabolic process (GO:0009111)2.19522825
172fat-soluble vitamin catabolic process (GO:0042363)2.19522825
173negative regulation of DNA-templated transcription, elongation (GO:0032785)2.19179628
174negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.19179628
175dosage compensation (GO:0007549)2.18838821
176mitotic metaphase plate congression (GO:0007080)2.18564175
177mitochondrial DNA replication (GO:0006264)2.18439146
178protein K6-linked ubiquitination (GO:0085020)2.18198319
179lipopolysaccharide metabolic process (GO:0008653)2.17979949
180peptidyl-lysine trimethylation (GO:0018023)2.17831211
181DNA conformation change (GO:0071103)2.17338440
182non-recombinational repair (GO:0000726)2.17253333
183double-strand break repair via nonhomologous end joining (GO:0006303)2.17253333
184mRNA cleavage (GO:0006379)2.17073805
185DNA integration (GO:0015074)2.16690947
186histamine transport (GO:0051608)2.16431471
187generation of neurons (GO:0048699)2.15829101
188regulation of histone H3-K9 methylation (GO:0051570)2.15536145
189monocyte chemotaxis (GO:0002548)2.14908180
190positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.14202750
191regulation of interleukin-6 biosynthetic process (GO:0045408)2.13754719
192B cell homeostasis (GO:0001782)2.13639504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.64043837
2ESR1_15608294_ChIP-ChIP_MCF-7_Human3.92041135
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.64251138
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.61567610
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.54961369
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.50765019
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36114204
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.20601873
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.04106188
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97474069
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91630054
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.90086772
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85862862
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.84069756
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79641755
16PADI4_21655091_ChIP-ChIP_MCF-7_Human2.74658706
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66212397
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.65059228
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50194549
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50125236
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47600804
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45789429
23ER_23166858_ChIP-Seq_MCF-7_Human2.45044863
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24979757
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24229902
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22261255
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18602024
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.16171047
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15154226
30PKCTHETA_26484144_Chip-Seq_BREAST_Human2.08663795
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.04098319
32GABP_19822575_ChIP-Seq_HepG2_Human2.01701043
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95520369
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.92583254
35DCP1A_22483619_ChIP-Seq_HELA_Human1.90027710
36AHR_22903824_ChIP-Seq_MCF-7_Human1.89306111
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87727599
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.85561720
39KDM5A_27292631_Chip-Seq_BREAST_Human1.85168401
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84876315
41XRN2_22483619_ChIP-Seq_HELA_Human1.82067297
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77855181
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.76410524
44IGF1R_20145208_ChIP-Seq_DFB_Human1.75972214
45IRF1_19129219_ChIP-ChIP_H3396_Human1.75144925
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.75081375
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74672805
48* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74116416
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73344643
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73082283
51ELK1_19687146_ChIP-ChIP_HELA_Human1.70781902
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69834412
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68563390
54SPI1_23547873_ChIP-Seq_NB4_Human1.67040260
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66657507
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65671788
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65344680
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65062725
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63387248
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61010858
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56762006
62ZNF274_21170338_ChIP-Seq_K562_Hela1.55743280
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51723722
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.49793099
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47800380
66SCL_19346495_ChIP-Seq_HPC-7_Human1.47505679
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47380322
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47150293
69FOXP3_21729870_ChIP-Seq_TREG_Human1.45421054
70AR_21909140_ChIP-Seq_LNCAP_Human1.45006272
71VDR_23849224_ChIP-Seq_CD4+_Human1.40951230
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40828280
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40650993
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40073261
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.37567320
76GATA3_24758297_ChIP-Seq_MCF-7_Human1.37554199
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.37332097
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36766000
79MYC_18940864_ChIP-ChIP_HL60_Human1.36364294
80CIITA_25753668_ChIP-Seq_RAJI_Human1.36010995
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34869821
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33130557
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32643649
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32115518
85VDR_21846776_ChIP-Seq_THP-1_Human1.31537217
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31319233
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31188459
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.28680041
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27894072
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.27691957
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27483016
92EWS_26573619_Chip-Seq_HEK293_Human1.27395604
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26913285
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.25567694
95VDR_24763502_ChIP-Seq_THP-1_Human1.23780226
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.23663010
97* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23551139
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21722774
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20944106
100* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19946238
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.18609262
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18398376
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17138720
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16290356
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15514500
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14667424
107* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14507216
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13901910
109MYB_26560356_Chip-Seq_TH2_Human1.12982607
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12413639
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11467187
112MYC_18555785_ChIP-Seq_MESCs_Mouse1.09383437
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06896045
114NMYC_18555785_Chip-Seq_ESCs_Mouse1.05735933
115ZNF263_19887448_ChIP-Seq_K562_Human1.05471705
116MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02554801
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01900586
118ELF5_23300383_ChIP-Seq_T47D_Human1.00670502
119MYB_26560356_Chip-Seq_TH1_Human1.00495501
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99828570
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99426702
122NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97298372
123MYC_22102868_ChIP-Seq_BL_Human0.96961694
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96628267
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.95946809
126MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95848778
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95562192
128FUS_26573619_Chip-Seq_HEK293_Human0.95431093
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94467602
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94081669
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93901761
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93810136
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90989176
134PU_27001747_Chip-Seq_BMDM_Mouse0.90983140
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90153788
136TTF2_22483619_ChIP-Seq_HELA_Human0.89754528
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.89560723
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89021002
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.88766089
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87736617
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87718882
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87204511
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86975372
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86899400
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86669612
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.86549637
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.86367166
148OCT4_18555785_Chip-Seq_ESCs_Mouse0.85980851
149RUNX_20019798_ChIP-Seq_JUKART_Human0.85767129
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.84711266
151* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84614403
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84128746
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84076825
154HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82612301
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.81013923
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80665183
157MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80327937
158P53_22387025_ChIP-Seq_ESCs_Mouse0.80284029
159P300_18555785_Chip-Seq_ESCs_Mouse0.80157905
160CHD1_26751641_Chip-Seq_LNCaP_Human0.80073961
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79750911
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.78234338
163TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77601582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.96297595
2MP0008058_abnormal_DNA_repair2.91397392
3MP0000569_abnormal_digit_pigmentation2.69449010
4MP0010094_abnormal_chromosome_stability2.63302388
5MP0010030_abnormal_orbit_morphology2.58991066
6MP0003693_abnormal_embryo_hatching2.57041069
7MP0000015_abnormal_ear_pigmentation2.55331019
8MP0000383_abnormal_hair_follicle2.53785047
9MP0004233_abnormal_muscle_weight2.45737797
10MP0005174_abnormal_tail_pigmentation2.43876707
11MP0002396_abnormal_hematopoietic_system2.41528032
12MP0008057_abnormal_DNA_replication2.29756285
13MP0008007_abnormal_cellular_replicative2.28954453
14MP0000537_abnormal_urethra_morphology2.24962881
15MP0009785_altered_susceptibility_to2.24943438
16MP0001188_hyperpigmentation2.23451732
17MP0001800_abnormal_humoral_immune2.16086342
18MP0003111_abnormal_nucleus_morphology2.11621229
19MP0006292_abnormal_olfactory_placode2.08407551
20MP0005076_abnormal_cell_differentiation2.06409695
21MP0003942_abnormal_urinary_system2.06022992
22MP0003303_peritoneal_inflammation2.05231472
23MP0005000_abnormal_immune_tolerance2.04392707
24MP0001790_abnormal_immune_system2.01349516
25MP0005387_immune_system_phenotype2.01349516
26MP0002452_abnormal_antigen_presenting1.96556494
27MP0003724_increased_susceptibility_to1.95993844
28MP0001293_anophthalmia1.95757227
29MP0003436_decreased_susceptibility_to1.92408007
30MP0002419_abnormal_innate_immunity1.91105816
31MP0005671_abnormal_response_to1.90472203
32MP0002723_abnormal_immune_serum1.85724660
33MP0003937_abnormal_limbs/digits/tail_de1.84732445
34MP0003763_abnormal_thymus_physiology1.84325315
35MP0003077_abnormal_cell_cycle1.82110151
36MP0005409_darkened_coat_color1.79311864
37MP0000427_abnormal_hair_cycle1.78468432
38MP0001529_abnormal_vocalization1.76820385
39MP0002420_abnormal_adaptive_immunity1.76488915
40MP0010678_abnormal_skin_adnexa1.75358957
41MP0001819_abnormal_immune_cell1.74081156
42MP0002148_abnormal_hypersensitivity_rea1.73284092
43MP0004264_abnormal_extraembryonic_tissu1.71885425
44MP0008789_abnormal_olfactory_epithelium1.70019742
45MP0002653_abnormal_ependyma_morphology1.69472953
46MP0004957_abnormal_blastocyst_morpholog1.68626939
47MP0003880_abnormal_central_pattern1.68591737
48MP0005075_abnormal_melanosome_morpholog1.65223376
49MP0000371_diluted_coat_color1.64157160
50MP0000538_abnormal_urinary_bladder1.61463417
51MP0009333_abnormal_splenocyte_physiolog1.58723991
52MP0005025_abnormal_response_to1.58450985
53MP0002398_abnormal_bone_marrow1.57068845
54MP0008995_early_reproductive_senescence1.53689681
55MP0009780_abnormal_chondrocyte_physiolo1.53422408
56MP0003315_abnormal_perineum_morphology1.52858399
57MP0002405_respiratory_system_inflammati1.48634321
58MP0000716_abnormal_immune_system1.45168260
59MP0000516_abnormal_urinary_system1.44434544
60MP0005367_renal/urinary_system_phenotyp1.44434544
61MP0002095_abnormal_skin_pigmentation1.44072963
62MP0002098_abnormal_vibrissa_morphology1.42430036
63MP0000689_abnormal_spleen_morphology1.42112538
64MP0002697_abnormal_eye_size1.40145928
65MP0002184_abnormal_innervation1.39892552
66MP0005499_abnormal_olfactory_system1.39766999
67MP0005394_taste/olfaction_phenotype1.39766999
68MP0003787_abnormal_imprinting1.39372788
69MP0000462_abnormal_digestive_system1.39230933
70MP0005248_abnormal_Harderian_gland1.38606690
71MP0001186_pigmentation_phenotype1.37254890
72MP0000534_abnormal_ureter_morphology1.37022510
73MP0001697_abnormal_embryo_size1.36777599
74MP0002006_tumorigenesis1.35189443
75MP0002160_abnormal_reproductive_system1.32972318
76MP0009703_decreased_birth_body1.32927318
77MP0004197_abnormal_fetal_growth/weight/1.32325001
78MP0009672_abnormal_birth_weight1.31348410
79MP0002085_abnormal_embryonic_tissue1.29643482
80MP0000703_abnormal_thymus_morphology1.29277743
81MP0002938_white_spotting1.26819707
82MP0001346_abnormal_lacrimal_gland1.25809470
83MP0002638_abnormal_pupillary_reflex1.25513053
84MP0002722_abnormal_immune_system1.24667967
85MP0003755_abnormal_palate_morphology1.21379807
86MP0003123_paternal_imprinting1.20175882
87MP0003786_premature_aging1.20133742
88MP0002075_abnormal_coat/hair_pigmentati1.19424966
89MP0002092_abnormal_eye_morphology1.19057975
90MP0008877_abnormal_DNA_methylation1.18465089
91MP0000490_abnormal_crypts_of1.17472899
92MP0004808_abnormal_hematopoietic_stem1.16729530
93MP0000647_abnormal_sebaceous_gland1.16630624
94MP0002933_joint_inflammation1.16016604
95MP0002429_abnormal_blood_cell1.15639540
96MP0000579_abnormal_nail_morphology1.15356708
97MP0005408_hypopigmentation1.14261566
98MP0003890_abnormal_embryonic-extraembry1.14228677
99MP0010307_abnormal_tumor_latency1.14165555
100MP0002233_abnormal_nose_morphology1.11709199
101MP0002084_abnormal_developmental_patter1.10547544
102MP0003936_abnormal_reproductive_system1.10082506
103MP0002009_preneoplasia1.08429450
104MP0005646_abnormal_pituitary_gland1.07766740
105MP0002277_abnormal_respiratory_mucosa1.07306061
106MP0003935_abnormal_craniofacial_develop1.07218558
107MP0003861_abnormal_nervous_system1.05460267
108MP0010155_abnormal_intestine_physiology1.03493772
109MP0002736_abnormal_nociception_after1.03334798
110MP0005380_embryogenesis_phenotype1.03155008
111MP0001672_abnormal_embryogenesis/_devel1.03155008
112MP0005464_abnormal_platelet_physiology1.01977801
113MP0000467_abnormal_esophagus_morphology1.01506912
114MP0002111_abnormal_tail_morphology1.01437412
115MP0005423_abnormal_somatic_nervous1.00553715
116MP0000049_abnormal_middle_ear0.98646528
117MP0002166_altered_tumor_susceptibility0.96565337
118MP0002249_abnormal_larynx_morphology0.95506376
119MP0002234_abnormal_pharynx_morphology0.94574239
120MP0001340_abnormal_eyelid_morphology0.94545106
121MP0004381_abnormal_hair_follicle0.94466734
122MP0001845_abnormal_inflammatory_respons0.93987994
123MP0003122_maternal_imprinting0.93949831
124MP0000377_abnormal_hair_follicle0.93817316
125MP0002796_impaired_skin_barrier0.93707695
126MP0003121_genomic_imprinting0.93597553
127MP0002088_abnormal_embryonic_growth/wei0.93030418
128MP0002210_abnormal_sex_determination0.92845321
129MP0000350_abnormal_cell_proliferation0.91320325
130MP0000313_abnormal_cell_death0.90981406
131MP0000627_abnormal_mammary_gland0.90699450
132MP0000858_altered_metastatic_potential0.90393035
133MP0003984_embryonic_growth_retardation0.90096425
134MP0002080_prenatal_lethality0.90047177
135MP0002116_abnormal_craniofacial_bone0.89486039
136MP0001533_abnormal_skeleton_physiology0.89258577
137MP0001119_abnormal_female_reproductive0.89190758
138MP0003115_abnormal_respiratory_system0.89126578
139MP0003448_altered_tumor_morphology0.87963761
140MP0009764_decreased_sensitivity_to0.87484732
141MP0002751_abnormal_autonomic_nervous0.87468917
142MP0005187_abnormal_penis_morphology0.86924135
143MP0002019_abnormal_tumor_incidence0.86846967
144MP0005501_abnormal_skin_physiology0.86507008
145MP0003866_abnormal_defecation0.86313842
146MP0008932_abnormal_embryonic_tissue0.85907838
147MP0003718_maternal_effect0.84917930
148MP0006276_abnormal_autonomic_nervous0.84015609
149MP0003567_abnormal_fetal_cardiomyocyte0.82859702
150MP0002177_abnormal_outer_ear0.82530399
151MP0003938_abnormal_ear_development0.82219133
152MP0009384_cardiac_valve_regurgitation0.80732330
153MP0000566_synostosis0.80597600
154MP0003943_abnormal_hepatobiliary_system0.78996724
155MP0000372_irregular_coat_pigmentation0.78859850
156MP0001919_abnormal_reproductive_system0.78768363
157MP0001986_abnormal_taste_sensitivity0.75631374
158MP0001286_abnormal_eye_development0.75541521
159MP0002163_abnormal_gland_morphology0.74893310
160MP0006082_CNS_inflammation0.74131949
161MP0009765_abnormal_xenobiotic_induced0.70525709
162MP0003186_abnormal_redox_activity0.70421364
163MP0000685_abnormal_immune_system0.69707159
164MP0003136_yellow_coat_color0.67117723
165MP0003941_abnormal_skin_development0.66786963
166MP0005390_skeleton_phenotype0.66631075
167MP0002132_abnormal_respiratory_system0.66268832
168MP0000465_gastrointestinal_hemorrhage0.64695165
169MP0009763_increased_sensitivity_to0.64484700
170MP0004133_heterotaxia0.63413225

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.05015266
2Chromsome breakage (HP:0040012)4.88666289
3Septate vagina (HP:0001153)4.81641851
4J-shaped sella turcica (HP:0002680)4.58425908
5Microglossia (HP:0000171)4.39733817
6Panhypogammaglobulinemia (HP:0003139)3.48977498
7Agammaglobulinemia (HP:0004432)3.44390995
8Absent frontal sinuses (HP:0002688)3.39203764
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.26180344
10Chronic mucocutaneous candidiasis (HP:0002728)3.24198369
11Recurrent cutaneous fungal infections (HP:0011370)3.24198369
12Asymmetry of the thorax (HP:0001555)3.23749462
13Colon cancer (HP:0003003)3.11230302
14Deformed sella turcica (HP:0002681)3.10990736
15Concave nail (HP:0001598)3.05844566
16Breast carcinoma (HP:0003002)3.02889087
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.90129635
18Recurrent viral infections (HP:0004429)2.88995931
19Abnormality of chromosome stability (HP:0003220)2.86987580
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.81581716
21Recurrent abscess formation (HP:0002722)2.78695875
22Meckel diverticulum (HP:0002245)2.75380844
23Chronic obstructive pulmonary disease (HP:0006510)2.72206953
24Obstructive lung disease (HP:0006536)2.72206953
25Clubbing of toes (HP:0100760)2.70245498
26Ectopic kidney (HP:0000086)2.66982447
27Abnormality of the preputium (HP:0100587)2.64623522
28Abnormality of the ileum (HP:0001549)2.64292361
29Micronodular cirrhosis (HP:0001413)2.63235897
30Meningitis (HP:0001287)2.60385397
31Generalized hypopigmentation of hair (HP:0011358)2.59013121
32Recurrent fungal infections (HP:0002841)2.56318863
33Duplicated collecting system (HP:0000081)2.52578169
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.50073361
35Recurrent bacterial skin infections (HP:0005406)2.45654728
36Mediastinal lymphadenopathy (HP:0100721)2.44810606
37Triphalangeal thumb (HP:0001199)2.43183993
38Severe combined immunodeficiency (HP:0004430)2.40523619
39Abnormality of the frontal sinuses (HP:0002687)2.36934927
40Abnormality of the renal collecting system (HP:0004742)2.35342007
41Hypopigmentation of the fundus (HP:0007894)2.35284144
42Increased nuchal translucency (HP:0010880)2.34669514
43Abnormality of the sella turcica (HP:0002679)2.33314546
44Hyperacusis (HP:0010780)2.32295153
45Recurrent lower respiratory tract infections (HP:0002783)2.30430668
46Short thumb (HP:0009778)2.29639583
47Midline defect of the nose (HP:0004122)2.28206654
48Recurrent skin infections (HP:0001581)2.27394895
49Spinal cord lesions (HP:0100561)2.26459216
50Syringomyelia (HP:0003396)2.26459216
51Recurrent pneumonia (HP:0006532)2.25978546
52Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.19379253
53Abnormality of DNA repair (HP:0003254)2.18587446
54Elfin facies (HP:0004428)2.16864557
55Myelodysplasia (HP:0002863)2.16707254
56Abnormality of the intervertebral disk (HP:0005108)2.16254388
57Granulocytopenia (HP:0001913)2.13114579
58Bone marrow hypocellularity (HP:0005528)2.12643162
59Eosinophilia (HP:0001880)2.12603256
60Elevated erythrocyte sedimentation rate (HP:0003565)2.11413151
61Neoplasm of the adrenal cortex (HP:0100641)2.09891530
62Morphological abnormality of the middle ear (HP:0008609)2.09735369
63Abnormality of the fingertips (HP:0001211)2.09525614
64Combined immunodeficiency (HP:0005387)2.09214686
65Bifid tongue (HP:0010297)2.08277661
66Abnormality of the carotid arteries (HP:0005344)2.07874489
67Reticulocytopenia (HP:0001896)2.07395390
68Eczematoid dermatitis (HP:0000976)2.07297638
69Lymphoma (HP:0002665)2.07197023
70Astigmatism (HP:0000483)2.06521237
71Periodontitis (HP:0000704)2.06272879
72Prostate neoplasm (HP:0100787)2.05474185
73Deep philtrum (HP:0002002)2.05427903
74Overriding aorta (HP:0002623)2.04751136
75Abnormality of the anterior horn cell (HP:0006802)2.04312301
76Degeneration of anterior horn cells (HP:0002398)2.04312301
77Hypothermia (HP:0002045)2.01546231
78Medulloblastoma (HP:0002885)2.00754175
79Thyroiditis (HP:0100646)1.99935861
80Encephalitis (HP:0002383)1.98998188
81Abnormality of T cell physiology (HP:0011840)1.96848429
82Vasculitis (HP:0002633)1.96738498
83Leukopenia (HP:0001882)1.96248365
84Basal ganglia calcification (HP:0002135)1.95922066
85Xerostomia (HP:0000217)1.95872849
86Glioma (HP:0009733)1.95152224
87Osteomalacia (HP:0002749)1.94844452
88Pulmonary fibrosis (HP:0002206)1.94824211
89Abnormality of the columella (HP:0009929)1.93972970
90Nephroblastoma (Wilms tumor) (HP:0002667)1.93810260
91Optic nerve coloboma (HP:0000588)1.92330874
92Gingivitis (HP:0000230)1.92078451
93Birth length less than 3rd percentile (HP:0003561)1.92067530
94Embryonal renal neoplasm (HP:0011794)1.91075029
95Ependymoma (HP:0002888)1.90900617
96Curly hair (HP:0002212)1.90377778
97Thyroid carcinoma (HP:0002890)1.90169461
98Inflammation of the large intestine (HP:0002037)1.88854714
99Type I transferrin isoform profile (HP:0003642)1.88479100
100Enlarged penis (HP:0000040)1.86686049
101Absent radius (HP:0003974)1.86175827
102Colitis (HP:0002583)1.85164037
103Cutaneous melanoma (HP:0012056)1.83602404
104Sloping forehead (HP:0000340)1.83275363
105Prominent metopic ridge (HP:0005487)1.81792761
106Embryonal neoplasm (HP:0002898)1.80925975
107Abnormality of the prostate (HP:0008775)1.80806998
108Abnormality of the labia minora (HP:0012880)1.80484571
109Renal duplication (HP:0000075)1.79704718
110Osteomyelitis (HP:0002754)1.79416056
111Papillary thyroid carcinoma (HP:0002895)1.79283324
112Renovascular hypertension (HP:0100817)1.78834757
113Arteriovenous malformation (HP:0100026)1.77943697
114Abnormality of T cells (HP:0002843)1.77854236
115Thyroid-stimulating hormone excess (HP:0002925)1.77228252
116Renal dysplasia (HP:0000110)1.77115296
117Abnormality of the metopic suture (HP:0005556)1.77053534
118Patellar aplasia (HP:0006443)1.76894086
119Myositis (HP:0100614)1.76826156
120Dental crowding (HP:0000678)1.76605860
121Abnormal number of incisors (HP:0011064)1.76092542
122Long toe (HP:0010511)1.76074334
123Abnormality of the nasal septum (HP:0000419)1.75534294
124Pulmonary artery stenosis (HP:0004415)1.75455357
125Abnormality of eosinophils (HP:0001879)1.74658205
126Cellulitis (HP:0100658)1.73493950
127Broad face (HP:0000283)1.73333774
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73134435
129Leukocytosis (HP:0001974)1.72805129
130Aplasia/Hypoplasia of the patella (HP:0006498)1.72660986
131Ocular albinism (HP:0001107)1.71392885
132Gastrointestinal inflammation (HP:0004386)1.71163099
133Absent forearm bone (HP:0003953)1.70979143
134Aplasia involving forearm bones (HP:0009822)1.70979143
135Submucous cleft hard palate (HP:0000176)1.70180189
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.70035320
137Pancreatic cysts (HP:0001737)1.69965666
138Small intestinal stenosis (HP:0012848)1.69235888
139Duodenal stenosis (HP:0100867)1.69235888
140Abnormality of glycolysis (HP:0004366)1.68919766
141Preaxial hand polydactyly (HP:0001177)1.68909789
142Chronic hepatic failure (HP:0100626)1.68700753
143Facial cleft (HP:0002006)1.68143738
144Bicornuate uterus (HP:0000813)1.67667741
145High pitched voice (HP:0001620)1.67665881
146Abnormality of B cell number (HP:0010975)1.67317657
147B lymphocytopenia (HP:0010976)1.67317657
148Duplication of thumb phalanx (HP:0009942)1.66672314
149Optic neuritis (HP:0100653)1.66608719
150Retrobulbar optic neuritis (HP:0100654)1.66608719
151Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.64086487
152Short 1st metacarpal (HP:0010034)1.64086487
153Benign neoplasm of the central nervous system (HP:0100835)1.63787094
154Meningioma (HP:0002858)1.63392731
155Patellar dislocation (HP:0002999)1.61966494
156Long nose (HP:0003189)1.60886980
157Abnormality of the duodenum (HP:0002246)1.60441317
158Abnormal lung lobation (HP:0002101)1.60429444
159Genital tract atresia (HP:0001827)1.60294610
160Septo-optic dysplasia (HP:0100842)1.59878776
161Dandy-Walker malformation (HP:0001305)1.59835305
162IgA deficiency (HP:0002720)1.59646728
163Anal stenosis (HP:0002025)1.59633093
164Long eyelashes (HP:0000527)1.59236714
165Vaginal atresia (HP:0000148)1.58651488
166High anterior hairline (HP:0009890)1.58025490
167Abnormality of the astrocytes (HP:0100707)1.55648295
168Astrocytoma (HP:0009592)1.55648295
169Abnormality of cochlea (HP:0000375)1.53467862
170Abnormality of the diencephalon (HP:0010662)1.52945584
171True hermaphroditism (HP:0010459)1.52700696
172Hepatoblastoma (HP:0002884)1.52223885
173Cerebellar dysplasia (HP:0007033)1.51949338
174Abnormality of the septum pellucidum (HP:0007375)1.51904214
175Absent thumb (HP:0009777)1.51482368
176Cafe-au-lait spot (HP:0000957)1.51215557
177Fibular aplasia (HP:0002990)1.49835962
178Proximal placement of thumb (HP:0009623)1.48976465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA4.07589889
2SCYL23.57699668
3PKN23.37370658
4SIK13.20601893
5IRAK33.02121729
6IRAK42.80267205
7MAP3K142.70954325
8TRIB32.67909187
9EIF2AK12.62811953
10ZAK2.59664371
11TRIM282.51326213
12BLK2.50136840
13MUSK2.48736580
14MAP4K22.44888828
15TNIK2.27898313
16EIF2AK22.22982413
17BMPR22.19129901
18VRK22.15314598
19ERBB32.11806859
20MAP3K62.09174473
21IKBKB2.01774861
22MAP2K31.99840881
23SRPK11.99588652
24TXK1.97687280
25IKBKE1.94460016
26YES11.80369456
27MKNK11.77764271
28MAP4K11.75363884
29CHUK1.71688687
30RPS6KA41.66425748
31NUAK11.63582175
32NME21.60618741
33CDK121.59097547
34NLK1.49442401
35ATR1.43563519
36MAPKAPK31.43043557
37PASK1.42384130
38WEE11.39387774
39CDK31.37274902
40TAF11.37037026
41NEK11.36577273
42EEF2K1.35562077
43MAP2K21.32181550
44CLK11.30363716
45EIF2AK31.30005360
46STK41.28782166
47FGFR21.28636030
48SIK31.27934297
49TTK1.27164660
50CDC71.26781462
51SMG11.26778906
52TSSK61.21947162
53MKNK21.21112397
54TAOK31.16617591
55PLK41.15359878
56PBK1.13447119
57PIK3CG1.09945529
58BRSK21.08198809
59JAK31.06487660
60TEC1.05661927
61PIM11.01986332
62BRD41.01354964
63TBK11.01121203
64RIPK40.99333574
65PRPF4B0.97955395
66TRPM70.97330367
67MAPK130.95874682
68IRAK20.94693233
69EPHA20.93073259
70IRAK10.93048782
71SGK20.93018245
72AKT30.91858763
73VRK10.91169165
74TLK10.90164011
75MAP3K100.89479498
76STK100.86764309
77DYRK30.85247963
78LYN0.84864508
79PIM20.83514954
80SYK0.83213636
81CASK0.81627637
82CAMK2B0.81028840
83BTK0.79200547
84CDK70.77659943
85STK160.76980150
86PLK10.76348508
87FGFR10.76345045
88BRSK10.75588113
89EPHA40.75155573
90ZAP700.74325199
91CAMK2D0.73338360
92CAMK2G0.73168171
93AURKB0.72035613
94NEK60.71691160
95RPS6KB20.71108009
96MTOR0.70844223
97FES0.69094468
98CHEK20.68849867
99PRKCI0.68711101
100CHEK10.68665498
101LCK0.68168485
102ADRBK20.67927833
103BUB10.67822411
104PLK30.67320677
105CSK0.66005017
106ILK0.64809176
107WNK30.64272199
108PNCK0.62918584
109ATM0.61858671
110SIK20.60020906
111DYRK20.59905328
112KIT0.59849053
113TYK20.58479453
114MAP2K60.58074744
115CSNK1A1L0.57314777
116NME10.57047718
117MAP3K120.55821745
118ICK0.55358427
119CSNK1D0.54181843
120MAP2K10.53639536
121PAK40.52414747
122HCK0.52098734
123BMPR1B0.51032982
124RPS6KB10.50197364
125NEK20.49926722
126CSF1R0.49471048
127RPS6KA20.49352146
128RPS6KA10.48726197
129SGK30.48062565
130GRK10.47373805
131SGK4940.45329084
132SGK2230.45329084
133MAP3K40.44521452
134FRK0.44234552
135AURKA0.43775905
136MAP2K70.43281035
137PRKCZ0.43028812
138MELK0.42731702
139ITK0.41981897
140BCR0.40556281
141AKT20.39892791
142CDK20.39537068
143TYRO30.39494087
144PRKCQ0.38788685
145MAPK140.38086558
146CDK10.37995287
147FGR0.36666453
148MAPKAPK20.36518366
149PRKACB0.35490458
150MAPK70.34820064
151STK390.34581284
152RET0.33892466
153PRKDC0.33442127
154PRKCE0.32229965
155MAPK80.31186259
156MAPKAPK50.30512749
157TESK20.29884866

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.45927838
2Fanconi anemia pathway_Homo sapiens_hsa034602.44493612
3Non-homologous end-joining_Homo sapiens_hsa034502.40015580
4Mismatch repair_Homo sapiens_hsa034302.27133372
5Base excision repair_Homo sapiens_hsa034102.20293766
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18255035
7Primary immunodeficiency_Homo sapiens_hsa053402.16245185
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.11953848
9DNA replication_Homo sapiens_hsa030302.10063951
10Leishmaniasis_Homo sapiens_hsa051402.03843804
11Graft-versus-host disease_Homo sapiens_hsa053321.95982044
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95627108
13Allograft rejection_Homo sapiens_hsa053301.94561429
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75566165
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.70144030
16Measles_Homo sapiens_hsa051621.69391757
17Herpes simplex infection_Homo sapiens_hsa051681.66822821
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66371315
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65151998
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59149528
21Thyroid cancer_Homo sapiens_hsa052161.54544992
22Spliceosome_Homo sapiens_hsa030401.46433425
23Selenocompound metabolism_Homo sapiens_hsa004501.45814570
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41941755
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39636331
26Fatty acid elongation_Homo sapiens_hsa000621.38092116
27B cell receptor signaling pathway_Homo sapiens_hsa046621.36224037
28Osteoclast differentiation_Homo sapiens_hsa043801.36067622
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34446508
30Cell cycle_Homo sapiens_hsa041101.30580712
31RNA degradation_Homo sapiens_hsa030181.29465705
32Basal transcription factors_Homo sapiens_hsa030221.28029219
33Nucleotide excision repair_Homo sapiens_hsa034201.27974788
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.27893708
35mTOR signaling pathway_Homo sapiens_hsa041501.27756868
36RNA polymerase_Homo sapiens_hsa030201.27126293
37Propanoate metabolism_Homo sapiens_hsa006401.26974692
38Influenza A_Homo sapiens_hsa051641.26301911
39Protein export_Homo sapiens_hsa030601.25624714
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24616630
41Hippo signaling pathway_Homo sapiens_hsa043901.24582700
42mRNA surveillance pathway_Homo sapiens_hsa030151.23517834
43One carbon pool by folate_Homo sapiens_hsa006701.23379845
44Endometrial cancer_Homo sapiens_hsa052131.23328782
45Type I diabetes mellitus_Homo sapiens_hsa049401.22737737
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21093123
47Asthma_Homo sapiens_hsa053101.19732945
48Pentose phosphate pathway_Homo sapiens_hsa000301.19259607
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18226452
50Pertussis_Homo sapiens_hsa051331.15741696
51Hematopoietic cell lineage_Homo sapiens_hsa046401.15707156
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15119757
53Legionellosis_Homo sapiens_hsa051341.13746326
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12865597
55Autoimmune thyroid disease_Homo sapiens_hsa053201.12289694
56RNA transport_Homo sapiens_hsa030131.11143948
57TNF signaling pathway_Homo sapiens_hsa046681.10224224
58Epstein-Barr virus infection_Homo sapiens_hsa051691.08908099
59Tuberculosis_Homo sapiens_hsa051521.07943993
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07780929
61Proteasome_Homo sapiens_hsa030501.06307877
62Phototransduction_Homo sapiens_hsa047441.04438471
63Biosynthesis of amino acids_Homo sapiens_hsa012301.02815992
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02402707
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00335092
66Antigen processing and presentation_Homo sapiens_hsa046120.98754344
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97994419
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97888804
69Systemic lupus erythematosus_Homo sapiens_hsa053220.97794139
70T cell receptor signaling pathway_Homo sapiens_hsa046600.97479370
71p53 signaling pathway_Homo sapiens_hsa041150.97465601
72Malaria_Homo sapiens_hsa051440.96484257
73Steroid biosynthesis_Homo sapiens_hsa001000.96221720
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95986337
75Salmonella infection_Homo sapiens_hsa051320.95715968
76Melanoma_Homo sapiens_hsa052180.95298351
77AMPK signaling pathway_Homo sapiens_hsa041520.95260302
78N-Glycan biosynthesis_Homo sapiens_hsa005100.94483536
79Apoptosis_Homo sapiens_hsa042100.92943413
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92663912
81Pyrimidine metabolism_Homo sapiens_hsa002400.91824604
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89432455
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89407418
84Shigellosis_Homo sapiens_hsa051310.89337794
85Notch signaling pathway_Homo sapiens_hsa043300.88879004
86Viral myocarditis_Homo sapiens_hsa054160.84820745
87Hepatitis B_Homo sapiens_hsa051610.81232550
88Viral carcinogenesis_Homo sapiens_hsa052030.80170917
89Carbon metabolism_Homo sapiens_hsa012000.79739960
90MicroRNAs in cancer_Homo sapiens_hsa052060.79409518
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.78699096
92Hepatitis C_Homo sapiens_hsa051600.78123858
93ErbB signaling pathway_Homo sapiens_hsa040120.76551877
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.76230230
95Tight junction_Homo sapiens_hsa045300.74179254
96Toxoplasmosis_Homo sapiens_hsa051450.74010447
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74007695
98Chemokine signaling pathway_Homo sapiens_hsa040620.73908465
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72193994
100HTLV-I infection_Homo sapiens_hsa051660.71195275
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71161729
102Choline metabolism in cancer_Homo sapiens_hsa052310.68752857
103Phagosome_Homo sapiens_hsa041450.68720101
104Ribosome_Homo sapiens_hsa030100.67496087
105Hedgehog signaling pathway_Homo sapiens_hsa043400.67492568
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67249558
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64050466
108Wnt signaling pathway_Homo sapiens_hsa043100.63862913
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63061688
110Rheumatoid arthritis_Homo sapiens_hsa053230.62494517
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61786204
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60965060
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60591444
114Acute myeloid leukemia_Homo sapiens_hsa052210.59934119
115Alcoholism_Homo sapiens_hsa050340.59789414
116Arachidonic acid metabolism_Homo sapiens_hsa005900.59423995
117Chronic myeloid leukemia_Homo sapiens_hsa052200.58865030
118Bladder cancer_Homo sapiens_hsa052190.58616080
119Staphylococcus aureus infection_Homo sapiens_hsa051500.58361825
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56943219
121Nitrogen metabolism_Homo sapiens_hsa009100.56668946
122Prostate cancer_Homo sapiens_hsa052150.56373153
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56331530
124Non-small cell lung cancer_Homo sapiens_hsa052230.56180685
125Pancreatic cancer_Homo sapiens_hsa052120.56120261
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54390734
127Colorectal cancer_Homo sapiens_hsa052100.53952077
128Lysine degradation_Homo sapiens_hsa003100.53259365
129Glioma_Homo sapiens_hsa052140.52011719
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.51982982
131Insulin signaling pathway_Homo sapiens_hsa049100.51615765
132Butanoate metabolism_Homo sapiens_hsa006500.51076403
133Adherens junction_Homo sapiens_hsa045200.51020686
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50942455
135Insulin resistance_Homo sapiens_hsa049310.50886534
136FoxO signaling pathway_Homo sapiens_hsa040680.50639366
137Small cell lung cancer_Homo sapiens_hsa052220.49350576
138Axon guidance_Homo sapiens_hsa043600.49213572
139Prolactin signaling pathway_Homo sapiens_hsa049170.49022638
140African trypanosomiasis_Homo sapiens_hsa051430.48032873
141Basal cell carcinoma_Homo sapiens_hsa052170.47858476
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.47507278
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47104085
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46503818
145Purine metabolism_Homo sapiens_hsa002300.45536331
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45329429
147TGF-beta signaling pathway_Homo sapiens_hsa043500.44185029
148Vitamin B6 metabolism_Homo sapiens_hsa007500.43444218
149Estrogen signaling pathway_Homo sapiens_hsa049150.43438387
150Oocyte meiosis_Homo sapiens_hsa041140.43047580
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.39667568
152Proteoglycans in cancer_Homo sapiens_hsa052050.39517641
153Regulation of autophagy_Homo sapiens_hsa041400.38744799
154Sulfur relay system_Homo sapiens_hsa041220.38686645
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38671267
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38551588
157Inositol phosphate metabolism_Homo sapiens_hsa005620.38549422
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37690706
159HIF-1 signaling pathway_Homo sapiens_hsa040660.35887329
160Fatty acid metabolism_Homo sapiens_hsa012120.35104858
161Huntingtons disease_Homo sapiens_hsa050160.31957820
162Metabolic pathways_Homo sapiens_hsa011000.29095220

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